JP5072296B2 - Slimming composition - Google Patents

Description

  The present invention relates to a slimming composition that exhibits an excellent slimming effect.

  Conventionally, for the purpose of slimming effect, medicinal ingredients such as caffeine, evergreen ivy extract, hammaris extract, green tea extract, black tea extract, oolong tea extract, seaweed extract and the like are blended in the slimming composition. Recently, a slimming skin external preparation (see Patent Document 1) characterized in that it contains a fennel extract that enhances lipase activity and promotes lipid metabolism, and a phosphodiesterase inhibitor guarana extract and carnitine derivative Slimming skin external preparation (see patent document 2), anti-obesity agent (see patent document 3) containing coffee extract and betaine, and aldose reductase that prevents various complications of diabetes with mate tea as an active ingredient Inhibitor (refer to Patent Document 4), gel-like thermal massage material containing ginger tincture (refer to Patent Document 5), skin external preparation having slimming effect containing mint extract and deep water (refer to Patent Document 6), A slimming cosmetic containing a kizuta extract, a hibermata extract and a parsley extract (see Patent Document 7) is known.

Japanese Patent No. 3292499 JP 2006-16383 A JP 2002-173435 A JP 2002-255837 A Japanese Patent Laid-Open No. 11-12126 Japanese Patent Laid-Open No. 10-182347 JP 2004-59520 A

  However, slimming compositions containing these medicinal ingredients are not effective enough, or if a sufficient amount is added to obtain medicinal effects, the feeling of use may be impaired, or the odor / discoloration There was a problem in the stability of the dosage form, and the improvement was desired.

  As a result of intensive studies to achieve the above object, the present inventors have found that the above problem can be solved by using a blood circulation promoter and an amino acid in combination, and have completed the present invention.

  That is, the present invention provides a slimming composition comprising a blood circulation promoter and an amino acid.

  In one aspect of the slimming composition of the present invention, as a blood circulation promoter, Ambibis Naga extract, salamander extract, gentian extract, coconut extract, chili extract, ginger extract, ginseng extract, ginkgo biloba extract, Arnica extract, safflower extract, assembly extract, merirot extract, horse chestnut extract, camphor and its derivatives, hinokitiol and its derivatives and their salts, tocopherol and its derivatives, nicotinic acid and its derivatives and their salts, 1 type (s) or 2 or more types selected from (gamma)-oryzanol and its derivative (s), vanillyl butyl ether, and sodium hydrogencarbonate are used.

  In one embodiment of the slimming composition of the present invention, the amino acid is one or two selected from leucine, isoleucine, valine, tryptophan, lysine, methionine, phenylalanine, threonine, valine, leucine, isoleucine, histidine, arginine. Use the above.

  ADVANTAGE OF THE INVENTION According to this invention, the composition for slimming which has the outstanding slimming effect and can be applied in wide field | areas, such as a skin external preparation and food-drinks, can be provided.

  An embodiment of the present invention will be described.

  The slimming composition of the present invention provides a slimming composition containing a blood circulation promoter and an amino acid.

  Although it does not specifically limit as a blood circulation promoter mix | blended in the composition for slimmings of this invention, Anmibis Naga extract, a salamander extract, a gentian extract, a coconut extract, a chili extract, a ginger extract, a ginseng extract, a ginkgo biloba Extract, arnica extract, safflower extract, assembly extract, merirot extract, horse chestnut extract, camphor and its derivatives, hinokitiol and its derivatives and their salts, tocopherol and its derivatives, nicotinic acid and its derivatives and their It is preferable to use 1 type or 2 types or more selected from the salt of (gamma)-oryzanol and its derivative (s), vanillyl butyl ether, and sodium hydrogencarbonate.

Here, Anmibisunaga (Ammi visnaga) is a dicotyledonous plant belonging to the Umbelliferae Cicuta virosa beetle genus. In the present invention, all parts of the above-ground part and underground part of Amibibis Naga can be used, and each part such as a seed, a fruit part, a flower part, a leaf part, a root part, and a stem part may be used alone or in combination as appropriate. Also good. In the present invention, it is preferable to use seeds. It is also possible to use a component obtained from Ambivis Naga, bisnadin.

  In the slimming composition of the present invention, the blending amount of the blood circulation promoter is 0.001 to 5% by mass, more preferably 0.01 to 3% by mass, based on the total amount of the slimming composition.

  Although it does not specifically limit as an amino acid mix | blended in the composition for slimming of this invention, or 1 type selected from leucine, isoleucine, valine, tryptophan, lysine, methionine, phenylalanine, threonine, valine, leucine, isoleucine, histidine, arginine or Two or more are preferably used. In this invention, it is especially preferable from the point of a slimming effect to use 1 type, or 2 or more types selected from leucine, isoleucine, and valine among these amino acids.

  The slimming composition of the present invention synergistically improves the slimming effect by using a blood circulation promoter and an amino acid in combination. In the composition for slimming of the present invention, the mixing ratio of the blood circulation promoter and the amino acid is not particularly limited, and the amino acid is in the range of 0.01 to 100 parts by mass with respect to 1 part by mass of the blood circulation promoter.

  The slimming composition of the present invention can be used as a slimming oral preparation in addition to a slimming external preparation.

  The dosage form of the external preparation for slimming is arbitrary, and can be provided as a solubilizing system such as lotion, an emulsifying system such as cream or milky lotion, or a dispersing system such as calamine lotion. Furthermore, it can also be provided in various dosage forms such as aerosols, ointments, powders and granules filled with a propellant. The blending amount of the slimming composition of the present invention when blended with an external preparation can be adjusted depending on the type of external preparation and the purpose of use. 0001-50.0 mass% is preferable, More preferably, it is 0.001-25.0 mass%.

  In addition to the slimming composition, the external preparation for blending the slimming composition is usually blended with pharmaceuticals, quasi-drugs, skin cosmetics, hair cosmetics and cleaning agents as necessary. Oily ingredients, moisturizers, powders, pigments, emulsifiers, solubilizers, detergents, UV absorbers, thickeners, drugs, fragrances, resins, antibacterial / antifungal agents, alcohols, etc. it can.

  The slimming composition of the present invention can be used as a slimming oral preparation by using it as a quasi-drug, a component of food or drink, a food additive, or the like. The use enables daily and continuous intake of the slimming composition having the slimming effect of the present invention. Examples of use of the slimming composition of the present invention as a food material include functional foods having a slimming effect or a preventive effect, health foods, general foods (juices, confectionery, processed foods, etc.), nutritional supplements (nutrient drinks) Etc.).

  Hereinafter, formulation examples and use tests of the slimming composition of the present invention will be described in more detail. However, the technical scope of the present invention is not limited by this.

With the formulation shown in Table 1, a warm sensation massage according to the slimming composition of the present invention was prepared, and a use test was conducted. In the use test, a total of 10 men and women between the ages of 20 to 50 who care about obesity were used as a group, and the examples or comparative examples were used blindly once a day for 2 weeks, and the waist before and after use was measured. The results are summarized in Table 1.
Judgment standard average reduced by 3.0 cm or more
Average decrease from 1.0 cm to less than 3.0 cm: ○
Average change in size before and after use is less than 1.0 cm: Δ
Average increase over 1.0 cm: ×

  As shown in Table 1, the slimming composition of the present invention exhibited a much higher slimming effect than the comparative example in which a blood circulation promoter or an amino acid was added alone.

[Prescription Example 2] Aerosol-type massage fee
(1) 2-alkyl-N-carboxymethyl 0.375 (mass%)
-N-hydroxyethylimidazolinium betaine
(2) l-menthyl glyceryl ether 0.025
(3) Allantoin 0.005
(4) Ethanol 3.750
(5) Citric acid 0.005
(6) Dipotassium glycyrrhizinate 0.005
(7) Ginger extract 0.002
(8) L-arginine 0.002
(9) Purified water 20.831
(10) Isobutane (propellant) 75.000
Production method: All components except isobutane are mixed and homogenized, and then filled into an aerosol container together with isobutane.

[Prescription Example 3] Body Gel
(1) 1,3-butylene glycol 2.00 (mass%)
(2) 2-Amino-2-methyl-1-propanol 0.30
(3) l-menthyl glyceryl ether 0.01
(4) Xanthan gum 0.50
(5) Polyethylene glycol 1540 1.00
(6) Polyoxyethylene (50EO) hydrogenated castor oil 0.20
(7) Tocopherol acetate 0.05
(8) Salamander extract 0.05
(9) L-leucine 0.05
(10) L-isoleucine 0.05
(11) L-valine 0.10
(12) Ethanol 40.00
(13) Purified water 55.69
Production method: All components were mixed and homogenized to prepare a body gel.

[Formulation Example 4] Bar soap
(1) Soap base 96.000 (mass%)
(2) Sodium alginate 0.004
(3) Edetate tetrasodium tetrahydrate 0.200
(4) Citric acid 0.020
(5) Lactic acid 0.010
(6) Assembly extract 0.005
(7) L-leucine 0.005
(8) L-isoleucine 0.005
(9) L-valine 0.005
(10) Bittern 0.005
(11) Purified water 3.741
Manufacturing method: After mixing and homogenizing all components, solid soap was prepared by press molding.

[Formulation Example 5] Bath salt
(1) Fragrance 0.300 (mass%)
(2) L-leucine 0.010
(3) L-isoleucine 0.005
(4) L-valine 0.005
(5) Hinokitiol 0.005
(6) Sodium bicarbonate 49.000
(7) Sodium sulfate 50.675
Manufacturing method: All components are mixed uniformly.

[Prescription Example 6] Beverage
(1) Merirot extract 0.005 (mass%)
(2) Panax ginseng extract 0.005
(3) L-leucine 0.005
(4) L-isoleucine 0.005
(5) L-valine 0.005
(6) Erythritol 1.000
(7) Citric acid 0.100
(8) Stevia 0.050
(9) Purified water 98.825
Manufacturing method: All components are mixed uniformly.

[Prescription Example 7] Tablet
(1) Ginkgo biloba extract 0.01 (parts by mass)
(2) L-leucine 0.01
(3) L-isoleucine 0.01
(4) L-valine 0.01
(5) Magnesium stearate 0.01
(6) Lactose 0.25
Production method: All components were mixed and tableted with a tableting machine to give tablets with a diameter of 10 mm and a mass of 300 mg.

[Prescription Example 8] Powder
(1) Safflower extract 0.005 (mass%)
(2) L-leucine 0.005
(3) L-isoleucine 0.005
(4) L-valine 0.005
(5) Bittern 0.010
(6) Reduced lactose 3000
(7) Soybean oligosaccharide 3000
(8) Erythritol 3000
(9) Dextrin 81.000
(10) Purified water 9.970
Manufacturing method: All components are mixed and stirred uniformly, and spray dried to form a powder.

[Prescription Example 9] Massage Gel
(1) Purified water 79.21 (mass%)
(2) Acrylic acid / alkyl methacrylate copolymer 0.50
(3) 1,3-butylene glycol 6.00
(4) Concentrated glycerin 3.00
(5) Hydrogenated soybean phospholipid 0.25
(6) Squalane 1.00
(7) Decamethylcyclopentasiloxane 1.50
(8) Paraoxybenzoic acid ester 0.10
(9) 2-Methylhexyl paramethoxycinnamate 4.00
(10) Polyglyceryl monoisostearate 0.20
(11) Potassium hydroxide (10 mass% aqueous solution) 2.00
(12) Purified water 2.00
(13) Amibibis Naga extract 0.10
(14) Pepper tincture 0.03
(15) L-valine 0.02
(16) L-isoleucine 0.02
(17) L-leucine 0.04
(18) γ-glutamic acid polypeptide 0.02
(19) l-menthyl glyceryl ether 0.01
Production method: (2) to (5) are dissolved in (1) to form an aqueous phase. (6) to (10) are uniformly dissolved to form an oil phase. After emulsification by adding the oil phase to the aqueous phase, the mixture of (12) to (19) is added to the mixture obtained by adding (11) to increase the viscosity.

Claims (1)

A composition for slimming comprising one or more selected from a blood circulation promoter: Ambivis Naga extract and an amino acid: leucine, isoleucine, and valine.