JP4907886B2 - Manufacturing method of joined body - Google Patents

Description

The present invention relates to the production how the conjugate.

  As a method for producing a ceramic composite body (joined body), for example, a method in which two molded bodies are separately manufactured and then fired by interposing a slurry in which primary particles for joining ceramic are dispersed between them is disclosed. (For example, refer to Patent Document 1).

  However, according to such a method, the two molded bodies and the slurry have different shrinkage rates at the time of firing, so that there is a problem in that the obtained bonded body is distorted, and deformation and poor bonding are likely to occur. .

JP 2000-169251 A

An object of the present invention, the two sintered bodies to easily and reliably joined, is to provide a manufacturing how the conjugate can be obtained joined body.

Such an object is achieved by the present inventions (1) to ( 2 ) below.
(1) A first sintered body and a second sintered body , which are mainly composed of a calcium phosphate compound and have different sintering temperatures, are prepared.
A temperature between the sintering temperature of the first sintered body and the sintering temperature of the second sintered body in a state where the first sintered body and the second sintered body are in direct pressure contact with each other. And manufacturing the joined body characterized in that the joined body is obtained by joining the first sintered body and the second sintered body.

Thereby, a 1st sintered compact and a 2nd sintered compact can be joined easily and reliably, and a joined body can be obtained.
In addition, calcium phosphate compounds have high biocompatibility and are useful as constituent materials for bone prosthetic materials such as artificial bones and artificial tooth roots.
Moreover, necessary and sufficient thermal energy for re-sintering is supplied to the two sintered bodies, and the joined body can be obtained more reliably.

(2) preparing a first sintered body and a second sintered body mainly composed of a calcium phosphate compound and having different porosity,
The first sintered body and the second sintered body are directly pressed and fired, and the first sintered body and the second sintered body are joined to obtain a joined body. The manufacturing method of the joined body characterized by these.

Thereby, a 1st sintered compact and a 2nd sintered compact can be joined easily and reliably, and a joined body can be obtained.
In addition, calcium phosphate compounds have high biocompatibility and are useful as constituent materials for bone prosthetic materials such as artificial bones and artificial tooth roots.
Moreover, thereby, a different function can be provided in each part of one joined body.

  According to the present invention, it is possible to easily and reliably join two sintered bodies to obtain a joined body.

  In addition, the two sintered bodies are fired and joined in a state where they are directly pressed together, and since the two sintered bodies are fired once, the shrinkage caused by the sintering during the firing is small, and the dimensions A bonded body with high accuracy can be obtained.

  Moreover, since the inclusion which bears joining to a joining surface, for example, the substance which has a bad influence on living bodies, such as a resin component, is not used, biological safety is high.

  Moreover, a different function can be provided in each part of one joined body by joining sintered bodies having different characteristics (for example, porosity).

  Furthermore, by providing the positioning means, it is possible to prevent positional displacement between the two sintered bodies and obtain a bonded body with higher dimensional accuracy.

  Hereinafter, the manufacturing method of a joined body and the joined body of the present invention will be described in detail based on preferred embodiments shown in the accompanying drawings.

  Hereinafter, a case where the joined body of the present invention is applied to a bone grafting material, particularly a vertebral arch spacer will be described as a representative.

  FIG. 1 is a perspective view showing an embodiment when the joined body of the present invention is applied to a vertebral spacer. 2 is a view for explaining a method of using the vertebral spacer shown in FIG. 1, (a) shows a state where the vertebral arch is cut, and (b) shows that the vertebral spacer is attached. Indicates the state.

  In the following description, the patient's ventral side (vertebral canal side) is referred to as “front” and the dorsal side is referred to as “rear”, based on the state where the vertebral spacer is attached to the vertebral arch.

  The lamina spacer 1 shown in FIG. 1 is composed of a block body having a substantially trapezoidal shape in plan view. In addition, a pair of flange portions 10 and 10 projecting to the side are provided at the rear end portion of the larch spacer 1.

  The larch spacer 1 is used in osteogenic spinal canal enlargement, which is one of surgical procedures for spinal diseases such as spinal stenosis and posterior longitudinal ligament ossification.

  Specifically, the vertebral arch spacer 1 cuts the vertebral arch 42 as shown in FIG. 2 (a), and the cut portion of the vertebral arch 42 formed by this cutting as shown in FIG. 2 (b). (Bone defect) 46 is inserted and installed (mounted).

  Hereinafter, for convenience of explanation, among the cut vertebral arches 42, the vertebral arch 42 on the spinous process 41 side separated from the vertebrae 47 is divided into the vertebral arch 42a on the spinous process side and the vertebrae 42 on the vertebra 47 (vertebral body) side. This is referred to as the vertebral side arch 42b. The cut surface of the spinous process side vertebra 42a is referred to as the spinous process side cut surface 43, and the cut surface of the vertebra side vertebra 42b is referred to as the vertebra side cut surface 44.

  With the vertebral spacer 1 installed at the cutting portion 46, the spinous process side cutting surface 43 and the vertebra side cutting surface 44 abut on the side surfaces 1a and 1b, respectively. Thereby, the distance between the spinous process side vertebral arch 42a and the vertebral side vertebral arch 42b can be kept constant.

  Further, in this state, the flange portions 10 and 10 come into contact with the outer sides of the end portions of the spinous process side vertebral arch 42a and the vertebral side vertebral arch 42b, respectively. Thereby, positioning of the vertebral arch spacer 1 with respect to the vertebral arch 42 is performed.

  In addition, the front surface 111 of the larch spacer 1 is formed of a concave curved surface. Thereby, in the state with which it mounted | wore with the vertebral arch 42, the vertebral spacer 1 can prevent effectively pressing a spinal nerve.

Such a lamina spacer 1 is a joined body obtained by joining the first sintered body 11 constituting the front portion and the second sintered body 12 constituting the rear portion.
Each of the sintered bodies 11 and 12 is mainly composed of a ceramic material.

  Examples of the ceramic material include calcium phosphate compounds, alumina, magnesia, beryllia, zirconia, forsterite, steatite, wollastonite, zircon, mullite, cordierite, spojumen, aluminum titanate, spinel, barium titanate, PZT, Examples include PLZT, ferrite, silicon nitride, sialon, aluminum nitride, boron nitride, titanium nitride, silicon carbide, boron carbide, titanium carbide, tungsten carbide, and the like.

  In particular, the ceramic material is preferably composed mainly of a calcium phosphate compound. That is, the sintered body is preferably composed mainly of a calcium phosphate compound. Calcium phosphate compounds have high biocompatibility and are useful materials as constituent materials for bone prosthetic materials such as artificial bones and artificial tooth roots.

  The calcium phosphate compound is formed by ionic bonding of calcium ions, phosphate ions and other ions. When sintered bodies containing a calcium phosphate compound as a main material are joined together, a joined body by intermolecular force can be obtained in the vicinity of the joining surface.

  As described above, the method for producing a joined body of the present invention is particularly suitably applied to joining sintered bodies having a calcium phosphate compound as a main component.

  Examples of the calcium phosphate compound include hydroxyapatite, tricalcium phosphate, halogenated apatite such as fluorapatite, and the like, and it is more preferable that the main component is hydroxyapatite. Since hydroxyapatite has a structure similar to that of the inorganic component of bone, it has a particularly excellent biocompatibility and is a more useful material as a constituent material of a bone prosthetic material.

  The sintered bodies 11 and 12 each preferably have a porosity of 60% or less, and more preferably 55% or less. Thus, if the sintered body has a relatively low porosity, that is, a relatively dense sintered body, the sintered body 11, Even when 12 are pressed together, destruction can be suitably prevented.

  In addition, the sintered bodies 11 and 12 may have substantially the same porosity, but are preferably different from each other.

  For example, the porosity of the first sintered body 11 can be set larger than the porosity of the second sintered body 12.

  In this case, in the first sintered body 11, efficient body fluid circulation is possible, and bone conduction from the spinous process side cut surface 43 and the vertebra side cut surface 44 can be promoted. As a result, the vertebral arch spacer 1 and the vertebral arch 42 come to fuse efficiently, and early bone formation can be achieved. On the other hand, in the second sintered body 12, the mechanical strength of the entire larch spacer 1 can be ensured.

  Moreover, although each sintered compact 11 and 12 can also be comprised with a different material, it is preferable that it is comprised with the same kind of material. By constituting each sintered body 11 and 12 with the same kind of material, the difference in the coefficient of thermal expansion between them can be reduced. Therefore, in sintering when the sintered bodies 11 and 12 are joined together, A positional shift between the first sintered body 11 and the second sintered body 12 due to the expansion difference can be prevented. As a result, a high dimensional accuracy lamina spacer 1 can be obtained.

  Hereinafter, a method of manufacturing the lamina spacer 1 by bonding the first sintered body 11 and the second sintered body 12 (a manufacturing method of the bonded body of the present invention) will be described.

<First Embodiment>
First, 1st Embodiment of the manufacturing method of the conjugate | zygote of this invention is described.

FIG. 3 is a diagram showing a first embodiment of a method for manufacturing a joined body according to the present invention, where (a) shows a state before joining, and (b) shows a state after joining.
In the following description, in FIG. 3, the upper side is referred to as “upper” and the lower side is referred to as “lower”.

[1] Manufacturing Process of First Sintered Body 11 and Second Sintered Body 12 First, molded bodies corresponding to the shapes of the first sintered body 11 and the second sintered body 12 are manufactured.

  This molded body is, for example, I: a method in which a slurry containing ceramic raw material powder is filled in a predetermined mold and molded, II: a method in which solid content is unevenly distributed to the slurry by precipitation or centrifugation, III: A method in which the slurry is put into a predetermined mold and dehydrated to leave a solid content in the mold, IV: a compression molding method (in the case of powder, compacting), V: a ceramic raw material powder and a water paste Can be produced by various methods such as mixing and drying in a mold. The slurry may contain secondary particles granulated in advance by a spray drying method or the like as a ceramic raw material powder.

  The obtained molded body is dried by, for example, natural drying, hot air drying, freeze drying, vacuum drying, or the like.

  Note that the molded body may be subjected to machining such as cutting, cutting, grinding, and polishing after the molding.

  Next, the molded body thus obtained is fired and sintered in a furnace, for example, to obtain a sintered body. For example, when the ceramic material is a calcium phosphate compound, the firing temperature at this time is preferably about 700 to 1300 ° C.

  The porosity of each of the sintered bodies 11 and 12 is, for example, the conditions for synthesizing the ceramic raw material powder (primary particle diameter, primary particle dispersion state, etc.) and the conditions for the ceramic raw material powder (average particle diameter, temporary Appropriate conditions for the presence or absence of firing, the presence or absence of pulverization, the conditions for stirring and foaming the slurry (type of surfactant, stirring force for stirring the slurry, etc.), the firing conditions (firing atmosphere, firing temperature, etc.) of the molded article, etc. By setting, a desired value can be set.

Moreover, you may make it use what is marketed as a sintered compact.
The sintered body may be a sintered body that has been almost completely sintered, or may be a sintered body that is not completely sintered (temporarily sintered body).

[2] Pressure welding process of first sintered body 11 and second sintered body 12 Next, as shown in FIG. The first sintered body 11 is placed so that the rear surface 112 of the sintered body 11 abuts. Further, a rectangular parallelepiped jig 20 as shown in FIG. 3A is placed on the first sintered body 11.

  Thereby, the first sintered body 11 is pressed downward by the dead weight of the jig 20, and the contact surface between the first sintered body 11 and the second sintered body 12 has both The pressure which presses is acted.

The magnitude of the pressure at the time of press contact is preferably as large as possible so that the sintered bodies 11 and 12 are not damaged. Specifically, the magnitude of the pressure is preferably from 0.05~5kgf / cm ^2, and more preferably 0.1~3kgf / cm ^2. If the pressure is smaller than the lower limit value, the sintered bodies 11 and 12 may not be sufficiently bonded to each other depending on the temperature and time during firing described later. On the other hand, if the magnitude of the pressure is larger than the upper limit value, the sintered bodies 11 and 12 may be damaged (for example, cracked or chipped).

  Examples of the constituent material of the jig 20 include various metal materials, various glass materials, various carbon-based materials, and the like, in addition to the ceramic materials mentioned in the above-described sintered body. A combination of the above can be used. Among these, as a constituent material of the jig 20, a material mainly made of a ceramic material is preferable. A ceramic material is preferable as a constituent material of the jig 20 because it has a high melting point and has a high hardness at high temperatures, so that it is difficult to melt or soften when the sintered bodies 11 and 12 are fired.

  Moreover, as a ceramic material, what has at least one of an alumina and a calcium-phosphate type compound as a main component is preferable. These have a low coefficient of thermal expansion and high heat resistance. Therefore, when firing each sintered body 11, 12, a pressure can be uniformly and stably applied to each sintered body 11, 12, which is particularly preferable as a constituent material of the jig 20.

  As a constituent material of the jig 20, it is preferable to select a material that is difficult to be bonded to the first sintered body 11 when the sintered bodies 11 and 12 are fired. For example, when the first sintered body 11 is composed mainly of hydroxyapatite, the constituent material of the jig 20 is preferably composed mainly of alumina.

  The shape of the jig 20 is not particularly limited as long as pressure can be applied to the sintered bodies 11 and 12.

[3] Firing step of first sintered body 11 and second sintered body 12 Next, the sintered bodies 11 and 12 are fired while maintaining the state of the step [2]. Thereby, the thermal energy at the time of baking is given to the contact surface of the 1st sintered compact 11 and the 2nd sintered compact 12. As a result, a new bond is generated between the crystal grains of the first sintered body 11 and the second sintered body 12 that are in contact with each other on the contact surface, and the first sintered body 11 and the second sintered body. 12 are joined together to obtain the larch spacer 1 shown in FIG.

  The temperature at the time of firing is appropriately set according to the constituent materials of the sintered bodies 11 and 12, and is not particularly limited. For example, when the sintering temperatures of the first sintered body 11 and the second sintered body 12 are different, the sintering temperature of the first sintered body 11 and the second sintered body are the firing temperatures. The sintering temperature of the first sintered body 11 is preferably set to a temperature between the sintering temperature of 12 and the sintering temperature of the first sintered body 11 and that of the second sintered body 12 are equal. It is preferable that the temperature is approximately equal to the sintering temperature and the sintering temperature of the second sintered body 12.

  In the former case, for example, when the constituent material of the first sintered body 11 is alumina and the constituent material of the second sintered body 12 is hydroxyapatite, the sintering temperature of alumina is about 1000 to 1800 ° C. On the other hand, since the sintering temperature of hydroxyapatite is about 900 to 1300 ° C., the firing temperature is preferably about 1000 to 1300 ° C., more preferably about 1100 to 1250 ° C.

  Thus, in the case where the sintering temperatures of the first sintered body 11 and the second sintered body 12 are different or equal, the temperature at which the sintered bodies 11 and 12 are fired. Is lower than the lower limit, the sintered bodies 11 and 12 may not be supplied with sufficient thermal energy necessary for re-sintering, and the sintered bodies 11 and 12 may not be sufficiently bonded. . On the other hand, if the temperature during firing is higher than the upper limit, re-sintering of each of the sintered bodies 11 and 12 is likely to proceed rapidly, resulting in oversintering, and the resulting lamina spacer (joined body) 1 There is a risk that the mechanical strength of the steel will decrease.

  The time for firing varies slightly depending on the firing temperature and the like, and is not particularly limited. However, it is preferably about 0.1 to 10 hours, more preferably about 1 to 5 hours. If the firing time is shorter than the lower limit value, the sintered bodies 11 and 12 are not sufficiently supplied with the thermal energy necessary for re-sintering, and the sintered bodies 11 and 12 are sufficiently joined. You may not be able to. On the other hand, if the firing time is longer than the upper limit value, the sintered bodies 11 and 12 are easily re-sintered and oversintered, and the mechanical strength of the obtained lamina spacer 1 is reduced. There is a risk.

  The atmosphere at the time of firing is not particularly limited, but for example, an oxidizing atmosphere such as air or oxygen, an inert atmosphere such as nitrogen, helium, neon, or argon, a reducing atmosphere such as hydrogen or carbon monoxide, or a reduced pressure atmosphere Etc.

  The above baking may be repeated a plurality of times for each of the sintered bodies 11 and 12 as necessary.

  The vertebral spacer 1 obtained in this manner is directly joined to each other without using a joining material. Accordingly, there is no possibility that a substance that adversely affects the living body, for example, a resin component or the like in the bonding material remains in the bonded body. For this reason, when the larch spacer 1 is placed in the living body, there is no elution of the substance (component) as described above, and safety is high.

Second Embodiment
Next, 2nd Embodiment of the manufacturing method of the conjugate | zygote of this invention is described.

FIG. 4 is a diagram showing a second embodiment of the method for manufacturing a joined body according to the present invention.
In the following description, in FIG. 4, the upper side is referred to as “upper” and the lower side is referred to as “lower”.

  Hereinafter, although the second embodiment will be described, the description will focus on the differences from the first embodiment, and the description of the same matters will be omitted.

  The second embodiment is different from the first embodiment except that the first sintered body 11 and the second sintered body 12 are provided with positioning means.

  As shown in FIG. 4, a ridge 117 protruding downward is formed at a substantially central portion in the longitudinal direction of the rear surface (joining surface) 112 of the first sintered body 11. The length of the ridge 117 is set to be approximately equal to the thickness (length in the short direction) of the first sintered body 11.

  On the other hand, a groove 127 is formed at a substantially central portion in the longitudinal direction of the front surface (joint surface) 121 of the second sintered body 12. The length of the groove 127 is set substantially equal to the thickness (length in the short direction) of the second sintered body 12.

  By superimposing the first sintered body 11 on the second sintered body 12, the protrusion 117 is inserted into the groove 127 and engaged. That is, in this embodiment, the positioning means is constituted by the ridge 117 and the groove 127.

  By providing such positioning means, when each sintered body 11, 12 is fired, the first sintered body 11 is prevented from being displaced in the longitudinal direction of the second sintered body 12. A highly accurate lamina spacer (joint) 1 can be obtained.

  Moreover, since the positioning means is provided on the joint surface of each of the sintered bodies 11 and 12, it is possible to prevent the shape of the target vertebral spacer 1 from being affected.

  In particular, the length of the ridge 117 is set to be approximately equal to the thickness of the first sintered body 11 and the length of the groove 127 is set to be approximately equal to the thickness of the second sintered body 12. The positioning means is included in the completed lamina spacer 1. As a result, for example, when the vertebral arch spacer 1 is placed on the cut portion (bone defect portion) 46 of the vertebral arch 42, the positioning means can be prevented from coming into contact with an unnecessary portion, and the operation can be reliably performed. Can be done.

  In addition, if it comprises so that the protruding item | line 117 may fit in the groove | channel 127, the position shift to the longitudinal direction of the 2nd sintered compact 12 of the 1st sintered compact 11 can be prevented more reliably, and more The vertebral spacer 1 with high dimensional accuracy can be obtained.

  In addition, as long as the positioning means can prevent the positional deviation between the first sintered body 11 and the second sintered body 12, the configuration (for example, the formation position and shape) is not particularly limited.

<Third Embodiment>
Next, a third embodiment of the method for manufacturing a joined body according to the present invention will be described.

  FIG. 5 is a view showing a third embodiment of the method for manufacturing a joined body according to the present invention, where (a) is a view of the first sintered body as seen from the rear, and (b) is a view of the second sintered body. It is the figure which looked at the united body from the front.

  In the following, the third embodiment will be described. The description will focus on the differences from the first and second embodiments, and the description of the same matters will be omitted.

  In the third embodiment, the configuration of the positioning means is different, and the rest is the same as in the second embodiment.

  As shown in FIG. 5A, a pair of protrusions 117 a and 117 a protruding to the side of the ridge 117 are formed at substantially the center in the longitudinal direction of the ridge 117. On the other hand, as shown in FIG. 5 (b), a pair of recesses 127 a and 127 a projecting to the side of the groove 127 are formed at the substantially central portion in the longitudinal direction of the groove 127.

  When the first sintered body 11 is superposed on the second sintered body 12, the protrusions 117 are inserted into and engaged with the grooves 127, and the protrusions 117a are inserted into the recesses 127a, respectively. Thereby, the position shift to the longitudinal direction and the transversal direction of the 2nd sintered compact 12 of the 1st sintered compact 11 can be prevented.

<Fourth embodiment>
Next, a fourth embodiment of the method for manufacturing a joined body according to the present invention will be described.

FIG. 6 is a diagram showing a fourth embodiment of a method for manufacturing a joined body according to the present invention.
In the following description, in FIG. 6, the upper side is referred to as “upper” and the lower side is referred to as “lower”.

  Although the fourth embodiment will be described, the differences from the first and second embodiments will be mainly described, and the description of the same matters will be omitted.

  In the fourth embodiment, the shape of the positioning means is different, and other than that is the same as the manufacturing method of the joined body of the second embodiment.

  As shown in FIG. 6, a projecting portion 118 that protrudes downward is formed at a substantially central portion of the rear surface 112 of the first sintered body 11. On the other hand, a hole 128 is formed in a substantially central portion of the front surface 121 of the second sintered body 12.

  When the first sintered body 11 is superposed on the second sintered body 12, the protrusion 118 is inserted into the hole 128 and engaged. Thereby, the position shift to the longitudinal direction and the transversal direction of the 2nd sintered compact 12 of the 1st sintered compact 11 can be prevented.

  In the present embodiment, the size of the positioning means can be set small. That is, the area of the joining surface of each of the sintered bodies 11 and 12 can be set to be relatively large. Thereby, the contact area when the 1st sintered compact 11 is piled up on the 2nd sintered compact 12 can be enlarged enough. As a result, the bonding strength between the first sintered body 11 and the second sintered body 12 can be further increased.

  In the jig 20 used in the embodiment as described above, the jig 20 and the first sintered body 11 are joined when the sintered bodies 11 and 12 are fired as necessary. You may make it provide the joining prevention means which prevents this.

  As this joining prevention means, for example, it can be constituted by a plurality of recesses or a release material layer provided on the surface of the jig 20.

  In the former case, the recesses may be, for example, discontinuous or continuous (grooves). When the concave portion is constituted by a groove, the grooves may be provided so as to be substantially parallel to each other, or may be provided so as to partially intersect, branch, or the like.

  In the latter case, a material that is difficult to be bonded to the first sintered body 11 or the second sintered body 12 is selected as a constituent material of the release material layer, and is not particularly limited. In addition to the ceramic material, for example, various glass materials, materials mainly composed of silicon, boron nitride, graphite, and the like can be given.

  By providing such a joining prevention means, it is possible to suitably prevent the jig 20 and the first sintered body 11 from joining when the sintered bodies 11 and 12 are fired. The vertebral spacer 1 can be easily and reliably detached from the jig 20 while more reliably preventing the vertebral arch spacer (joined body) 1 from being damaged.

  As mentioned above, although the manufacturing method and joined body of the conjugate | zygote of this invention were demonstrated based on embodiment of illustration, this invention is not limited to these.

  For example, the method for manufacturing a joined body of the present invention can also be applied when three or more sintered bodies are joined.

Next, specific examples of the present invention will be described.
1. 1. Production of sintered body 1-1. Production of first sintered body (Sample No. 1A)
First, a hydroxyapatite slurry was prepared from a calcium hydroxide slurry and an aqueous phosphoric acid solution by a known wet synthesis method. This was dried by a spray drying method, and then calcined at 700 ° C. in an atmospheric furnace to obtain a spherical powder.

  Next, the obtained hydroxyapatite spherical powder and the polymer compound aqueous solution were mixed and stirred to form bubbles in the mixed solution. This mixture was dried to obtain a molded body.

  The shrinkage after sintering was calculated, and using a band saw and a machining center, the compact was processed so as to have a shape equal to that of the first sintered body 11 shown in FIG. 3 after sintering.

  This molded body was placed in an atmospheric furnace and fired at 1200 ° C. for 4 hours to obtain a sintered body having the same shape as the first sintered body 11 shown in FIG.

  The obtained sintered body had dimensions: width 18 mm × thickness 8 mm × height 5.1 mm, and porosity: 50%.

(Sample No. 2A)
Except for shortening the stirring time of the mixed solution and reducing the number of bubbles generated in the mixed solution, the sample No. A sintered body was produced in the same manner as in 1A.

  Note that the porosity of the obtained sintered body was 30%.

(Sample No. 3A)
Except that the molded product was obtained by rubber pressing a spherical powder of hydroxyapatite with a pressing force of 2 t / cm 2, the above sample No. A sintered body was produced in the same manner as in 1A.
In addition, the porosity of the obtained sintered body was about 0%.

(Sample No. 4A)
Except that the shape of the obtained sintered body was the same as that of the first sintered body 11 shown in FIG. A sintered body was produced in the same manner as in 1A.

(Sample No. 5A)
Sample No. 5 was obtained except that the shape of the obtained sintered body was the same as that of the first sintered body 11 shown in FIG. A sintered body was produced in the same manner as in 1A.

(Sample No. 6A)
Except that the shape of the obtained sintered body was the same as that of the first sintered body 11 shown in FIG. A sintered body was produced in the same manner as in 1A.

1-2. Production of second sintered body (Sample No. 1B)
Except that the shape of the obtained sintered body was the same as that of the second sintered body 12 shown in FIG. A sintered body was produced in the same manner as in 1A.
The obtained sintered body had dimensions: width 24 mm × thickness 8 mm × height 4.6 mm.

(Sample No. 2B)
Except for shortening the stirring time of the mixed solution and reducing the number of bubbles generated in the mixed solution, the sample No. A sintered body was produced in the same manner as in 1B.
Note that the porosity of the obtained sintered body was 30%.

(Sample No. 3B)
Except that the molded product was obtained by rubber pressing a spherical powder of hydroxyapatite with a pressing force of 2 t / cm 2, the above sample No. A sintered body was produced in the same manner as in 1B.
In addition, the porosity of the obtained sintered body was about 0%.

(Sample No. 4B)
Except that the shape of the obtained sintered body was the same as that of the second sintered body 12 shown in FIG. A sintered body was produced in the same manner as 2B.

(Sample No. 5B)
Except that the shape of the obtained sintered body was the same as that of the second sintered body 12 shown in FIG. A sintered body was produced in the same manner as 2B.

(Sample No. 6B)
Except that the shape of the obtained sintered body was the same as that of the second sintered body 12 shown in FIG. A sintered body was produced in the same manner as 2B.

(Sample No. 7B)
Except that the constituent material of the sintered body was tricalcium phosphate, the sample No. A sintered body was produced in the same manner as 2B.
Note that the porosity of the obtained sintered body was 30%.

2. Manufacture of Lingual Spacer In the following, as shown in each of the examples and comparative examples, each larch spacer was manufactured.
In each example and comparative example, 20 vertebral spacers were manufactured.

Example 1
As shown in FIG. 2B, sample no. 1A was piled up and a jig was placed thereon. In this state, the two sintered bodies were fired at 1200 ° C. for 0.05 hours to join the two sintered bodies to obtain a vertebral spacer (joint) shown in FIG. .
The specifications of the jig are as shown below.

Constituent material: Alumina Weight (pressure): 3500 g (2.43 kgf / cm ² )

(Examples 2 to 8)
As shown in Table 1, lamina spacers were obtained in the same manner as in Example 1 except that the firing conditions were changed.

Example 9
Sample No. 1 was used as the first sintered body. 2A as a second sintered body, sample No. A lamina spacer was obtained in the same manner as in Example 3 except that 1B was used.

(Example 10)
Sample No. 1 was used as the first sintered body. 2A as a second sintered body, sample No. A lamina spacer was obtained in the same manner as in Example 3 except that 3B was used.

(Example 11)
Sample No. 1 was used as the first sintered body. 1A was used as a second sintered body. A lamina spacer was obtained in the same manner as in Example 3 except that 1B was used.

(Example 12)
Sample No. 1 was used as the first sintered body. 3A as a second sintered body. A lamina spacer was obtained in the same manner as in Example 3 except that 3B was used.

(Example 13)
Sample No. 1 was used as the first sintered body. 4A as a second sintered body, sample No. A lamina spacer was obtained in the same manner as in Example 3 except that 4B was used.

(Example 14)
Sample No. 1 was used as the first sintered body. Sample No. 5A was used as the second sintered body. A lamina spacer was obtained in the same manner as in Example 3 except that 5B was used.

(Example 15)
Sample No. 1 was used as the first sintered body. 6A as a second sintered body. A lamina spacer was obtained in the same manner as in Example 3 except that 6B was used.

(Example 16)
Sample No. 1 was used as the first sintered body. 2A as a second sintered body, sample No. A lamina spacer was obtained in the same manner as in Example 3 except that 7B was used.

(Comparative example)
A lamina spacer was obtained in the same manner as in Example 3 except that no jig was used.

3. Evaluation Regarding the lamina spacer obtained in each Example and Comparative Example, it was confirmed whether or not the first sintered body and the second sintered body were joined to each other.

  And the number of what joined the 1st sintered compact and the 2nd sintered compact was evaluated according to the four-step standard shown below.

A: 19 pieces (95%) or more B: 17 pieces (85%) or more and less than 19 pieces (95%) Δ: Less than 17 pieces (85%) ×: Cannot be joined Table 1 shows the results.

  As shown in Table 1, in each Example, it was possible to join the first sintered body and the second sintered body.

  In particular, by setting the temperature and time at the time of firing, there was a tendency to join more reliably.

  On the other hand, in the comparative example, it was difficult to join the first sintered body and the second sintered body.

It is a perspective view which shows embodiment at the time of applying the conjugate | zygote of this invention to a larch spacer. It is a figure for demonstrating the usage method of the larch spacer shown in FIG. It is a figure which shows 1st Embodiment of the manufacturing method of the conjugate | zygote of this invention. It is a figure which shows 2nd Embodiment of the manufacturing method of the conjugate | zygote of this invention. It is a figure which shows 3rd Embodiment of the manufacturing method of the conjugate | zygote of this invention. It is a figure which shows 4th Embodiment of the manufacturing method of the conjugate | zygote of this invention.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Larch spacer 1a, 1b Side surface 10 Flange part 11 1st sintered body 111, 121 Front surface 112 Rear surface 117 Projection 117a Protrusion 118 Protrusion part 12 2nd sintered body 127 Groove 127a Recessed part 128 Hole part 20 Jig 41 Spinous process 42 vertebral arch 42a spinous process side vertebral arch 42b vertebral side vertebral arch 43 spinous process side cut surface 44 vertebral side cut surface 45 spinal canal 46 cutting part 47 vertebra

Claims (2)

Preparing a first sintered body and a second sintered body mainly composed of a calcium phosphate compound and having different sintering temperatures ;
A temperature between the sintering temperature of the first sintered body and the sintering temperature of the second sintered body in a state where the first sintered body and the second sintered body are in direct pressure contact with each other. And manufacturing the joined body characterized in that the joined body is obtained by joining the first sintered body and the second sintered body. A first sintered body and a second sintered body, which are mainly composed of a calcium phosphate compound and have different porosity, are prepared.
  The first sintered body and the second sintered body are directly pressed and fired, and the first sintered body and the second sintered body are joined to obtain a joined body. The manufacturing method of the joined body characterized by these.

Images