JP4873155B2 - Tooth whitening composition and tooth whitening set - Google Patents

Description

  The present invention relates to a tooth whitening composition and a tooth whitening set for making a tooth whiter than the original color. More specifically, the present invention relates to a tooth whitening composition which is applied or applied to a tooth and a powder such as titanium dioxide is applied to the tooth for a certain period of time. The present invention relates to a tooth whitening composition and a tooth whitening set, which are fixed to the surface of the tooth and make teeth appear white by irregular reflection and exhibit a high whitening effect for a long time.

  Conventional techniques for whitening teeth include (1) a technique for removing colored substances attached to the teeth and restoring the whiteness of the original teeth, and (2) a technique for making the teeth whiter than the original color. Separated. As the method of (1), using a dentifrice or toothbrush, a physical removal method by brushing with a polishing component contained in the dentifrice, a solubilizer such as polyethylene glycol or polyvinylpyrrolidone, an enzyme, a chelating agent, etc. Chemical methods such as decomposing colored materials are used, and (2) methods include bleaching using peroxides frequently used in Europe and the United States, and concealing agents typified by dental nail polish. Dental materials such as coated or laminated veneers have been used.

  In recent years, with the improvement of oral hygiene awareness and desire for aesthetics, the need for whitening teeth is shifting from “cleaning” in (1) to “whitening” in (2). However, bleaching with peroxides may cause gingival irritation and regression, and it is extremely dangerous for consumers without expert knowledge to use it without permission. On the other hand, since coating agents such as nail polish are peeled off by eating and drinking, etc., they lack sustainability. In addition, the laminate veneer method can only be performed by a dentist, and it is necessary to cut the surface of a healthy tooth. Even if the patient is not satisfied with the result, it cannot be restored to the original tooth after the operation. .

  In view of the above, in the field of “whitening”, it has been desired to develop a tooth whitening technique that has good aesthetics, is simple and has high safety.

  As such whitening technology, coating agents such as nail polish utilizing the film forming ability of shellac, vinyl acetate resin and acrylic resin have been proposed (Japanese Patent Laid-Open Nos. 04-82821 and 05-58844). There is a problem in the rough feeling of use of the coating agent coated on the teeth, Japanese Patent Laid-Open No. 09-1000021, Japanese Patent Laid-Open No. 09-202718, and Japanese Patent Laid-Open No. 09-151123. Moreover, although it is disclosed that the particle size of titanium oxide used in combination with a coating agent is preferably 100 nm or less (Japanese Patent Application Laid-Open No. 09-151123), the titanium oxide to the teeth when not using the coating agent is disclosed. The adsorptivity was not always sufficient.

The specific surface area of titanium oxide generally used as a pigment in dentifrices and the like is 10 to 20 m ² / g, and a metal oxide having a specific surface area in this range can be used without a support such as a coating agent. Even when applied to the tooth, the adsorptivity to the teeth was low, and a sufficient whitening effect could not be exhibited.

  On the other hand, Japanese Patent Application Laid-Open No. 2003-183142 discloses a method and composition for enhancing the adsorptivity to enamel and making teeth appear white by performing an activation treatment to increase the number of surface hydroxyl groups of the metal oxide. Has been. However, since it is necessary to treat the metal oxide under high alkali conditions as a pretreatment, there are problems in operability and safety.

  Accordingly, an object of the present invention is a tooth whitening composition for making a tooth whiter than the original color, which is applied or applied to the tooth, and a powder such as titanium dioxide is fixed to the tooth surface for a certain period of time. Tooth whitening that makes teeth appear white due to diffuse reflection and holds the powder on the tooth surface stably for a long time, greatly reducing color unevenness and peeling and providing a high whitening effect continuously. It is to provide a composition and a set for tooth whitening.

  As a result of intensive studies in order to solve the above problems, the present inventors have found that whitening powder selected from titanium dioxide, silicon dioxide, zinc oxide, aluminum oxide, magnesium oxide, zirconium oxide, and a gelling agent By combining pullulan with a cationic polymer selected from lysozyme, cationized cellulose, and polylysine, whitening powder is stably fixed on the tooth surface for a long time, and color unevenness and peeling are greatly reduced. The inventors have found that the whitening effect is sustained, and have made the present invention.

Therefore, the present invention
(A) One or more selected from titanium dioxide, silicon dioxide, zinc oxide, aluminum oxide, magnesium oxide, zirconium oxide,
(B) Pullulan,
(C) A tooth whitening composition characterized by containing one or more selected from lysozyme, cationized cellulose, and polylysine.

  The present invention also provides a tooth whitening set comprising an application tool that is detachably attached to a tooth while holding the tooth whitening composition. In this case, examples of the application tool include a tape, a sheet, a film, a mouth tray, a mouthpiece, a sponge, an impression material, a pack material, or a tooth cover molded into a dentition.

  According to the present invention, the metal oxide powder having excellent adsorptivity to teeth can diffusely reflect light on the tooth surface and appear whiter than the original color. The powder can be held on the tooth surface and a high whitening effect can be exhibited continuously.

  Component (A) used in the tooth whitening composition of the present invention is a metal oxide selected from titanium dioxide, silicon dioxide, zinc oxide, aluminum oxide, magnesium oxide, and zirconium oxide, preferably titanium dioxide and zinc oxide. , Aluminum oxide and zirconium oxide, one or more of these being used, and a composite of these metal oxides.

  The presence or absence of the surface treatment is not particularly limited for the metal oxide used in the present invention, but those coated with silicon dioxide, alumina and zirconium oxide are also preferably used for the purpose of suppressing the catalytic activity of the metal oxide.

  The blending amount of the metal oxide of the component (A) used in the present invention is not particularly limited as long as a sufficient amount can be released from the tooth whitening composition to the tooth surface, but preferably 0.1% of the entire composition. -50 mass%, More preferably, it is 0.5-20 mass%. When the blending amount is less than 0.1% by mass, a sufficient whitening effect cannot be obtained, and when it exceeds 50% by mass, it becomes a composition having poor usability depending on the application form to the tooth. May end up.

  As for the average particle diameter of the metal oxide used as (A) component of this invention, 0.005-5 micrometers is preferable. Most preferably, it is 0.01-1 micrometer. When the average particle diameter is less than 0.005 μm, the light cannot be sufficiently scattered, and the whitening effect may not be obtained. When the average particle diameter exceeds 5 μm, the fixation to the teeth is not sufficient, and the whitening effect may not be sustained. In addition, in this invention, an average particle diameter is a measured value of 50% particle diameter by a micro track particle size analyzer (Nikkiso Co., Ltd.).

  The pullulan as the component (B) used in the present invention is a polymer in which maltotriose is α1-6 bonded, and examples thereof include those having a weight average molecular weight of about 4 to 800,000. Of these, those having 100,000 to 500,000 are particularly preferred. The weight average molecular weight of pullulan is determined by a gel permeation chromatograph (GPC) method using polyethylene oxide having a known molecular weight as a standard substance and dimethylformamide added with LiBr as a solvent. Pullulan is polyacrylic acid or a salt thereof, carboxyvinyl polymer, vinyl acetate / vinyl pyrrolidone copolymer, cellulose derivatives such as sodium carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, polyvinyl pyrrolidone, polyvinyl alcohol, xanthan gum, carrageenan, alginate It can be used in combination with other water-soluble polymers. The blending amount of the pullulan in the composition is preferably in the range of 0.1 to 20% by mass, particularly in the range of 0.3 to 15% by mass of the whole composition. In this case, it is preferable to select the blending amount according to the molecular weight of pullulan. In particular, when the weight average molecular weight is about 790,000, 0.1 to 5% by mass is preferable, and more preferably 0.3 to 3% by mass. . When the weight average molecular weight is about 400,000, it is preferably 0.1 to 7% by mass, and more preferably 0.5 to 5% by mass. When the weight average molecular weight is about 200,000, it is preferably 0.3 to 15% by mass, and more preferably 0.5 to 10% by mass. When the weight average molecular weight is about 47,000, the content is preferably 0.5 to 20% by mass, and more preferably 1 to 15% by mass. When the blending amount of pullulan is less than the preferred blending amount in each weight average molecular weight, even when combined with other water-soluble polymers, the adsorptivity and sustainability of the composition to the teeth are low, and the metal oxide is There are cases where it cannot be stably adsorbed to teeth for a long time. Moreover, when the preferable compounding quantity in each weight average molecular weight is exceeded, the viscosity of a composition becomes high and sufficient metal oxide may not adsorb | suck to a tooth | gear.

  The component (C) used in the present invention is one or more selected from lysozyme, cationized cellulose, and polylysine.

  The lysozyme is preferably lysozyme chloride. The blending amount of lysozyme is preferably from 0.1 to 10% by weight, more preferably from 0.5 to 5% by weight, based on the entire composition. When the blending amount of lysozyme is less than 0.1% by mass, the adsorptivity and persistence of the composition on the teeth are low, and the metal oxide may not be stably adsorbed on the teeth for a long time. On the other hand, if it exceeds 10% by mass, the bitterness peculiar to lysozyme becomes strong, and the taste of the composition may deteriorate.

  As the cationized cellulose, hydroxydimethylallylammonium chloride or O- {2-hydroxy-3- (trimethylammonio)} propylhydroxyethylcellulose chloride is preferably used. A weight average molecular weight of about 300,000 to about 2 million is preferably used. When the weight average molecular weight is less than 300,000, the fixity to the teeth is not sufficient, and the whitening effect may not be sustained. When the weight average molecular weight is more than 2 million, the viscosity of the preparation is increased and the operability is improved. It may be damaged. The substitution degree of the cationic group is preferably 0.5 to 3% by mass as the nitrogen content. When the nitrogen content is less than 0.5% by mass, the fixity to the teeth is not sufficient, and the whitening effect may not be sustained. When the nitrogen content exceeds 3% by mass, the taste is poor and the feeling of use is poor. May decrease. The weight average molecular weight is a value determined by a gel permeation chromatograph (GPC) method using polyethylene glycol as a standard substance. The nitrogen content is a value obtained by CHN organic element analysis. 0.1-5 mass% of the whole composition is preferable, and, as for the compounding quantity of a cationized cellulose, 0.5-3 mass% is still more preferable. When the blending amount of cationized cellulose is less than 0.1% by mass, the adsorptivity and persistence of the composition on the teeth are low, and the metal oxide may not be stably adsorbed on the teeth for a long time. On the other hand, when it exceeds 5% by mass, the viscosity of the composition increases, and a sufficient amount of metal oxide may not be adsorbed on the teeth.

As polylysine, salts such as polylysine alone, polylysine hydrochloride and polylysine hydrobromide can be used. The number average molecular weight of polylysine can be 1,000 to 1,000,000, with 3000 to 300,000 being particularly preferred. When the number average molecular weight is less than 1000, the fixity to the teeth is not sufficient, and the whitening effect may not be sustained. When the number average molecular weight is more than 1 million, the viscosity of the preparation increases and the operability is impaired. May be. The method for measuring the number average molecular weight is not particularly limited. For example, the number average molecular weight can be determined by the gel permeation chromatograph low angle light scattering method (GPC-LALLS method) using polystyrene as a standard substance under the following conditions. it can.
Column: Tosoh Biosep G5000 PW _XL , 7.8 mm × 30 cm
Moving layer: 0.1 mol / L sodium phosphate buffer (pH 7.0)
Flow rate: 0.5 mL / min
Column temperature: 40 ° C

  Moreover, 0.01-20 mass% of the whole composition is preferable, and, as for the compounding quantity of polylysine, 0.5-10 mass% is still more preferable. When the blending amount of polylysine is less than 0.01% by mass, the adsorptivity and persistence of the composition on the teeth are low, and the metal oxide may not be stably adsorbed on the teeth for a long time. On the other hand, when it exceeds 20% by mass, the viscosity of the composition increases, and a sufficient amount of metal oxide may not be adsorbed on the teeth.

  In addition to the above components, the composition for tooth whitening of the present invention is further formulated with a gelling agent that can be applied to teeth for a long time and prevents the tooth whitening composition from dissolving into the entire oral cavity according to its form. Can do.

  The gelling agent used in the present invention is not particularly limited, but polyacrylic acid or a salt thereof, carboxyvinyl polymer, vinyl acetate / vinyl pyrrolidone copolymer, cellulose derivatives such as sodium carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, polyvinyl Pyrrolidone, polyvinyl alcohol, xanthan gum, carrageenan, and alginate are preferably used, and one or more selected from these can be blended.

  0.1-10 mass% of the whole composition is suitable for the compounding quantity of the said gelatinizer, and 0.5-5 mass% is especially desirable. If the blending amount exceeds 10% by mass, the gelling agent may not be sufficiently dissolved, resulting in not only a non-uniform preparation but also inhibition of the preparation on the tooth surface. When the blending amount is less than 0.1% by mass, an uncomfortable feeling such as stickiness in the mouth due to gel dissolution may occur.

In the tooth whitening composition of the present invention, other components can be appropriately blended as necessary.
For example, for the purpose of emulsification and dispersion, one or more of an anionic surfactant, a nonionic surfactant and a zwitterionic surfactant can be used in combination as the surfactant.
In this case, anionic surfactants include sodium alkyl sulfates such as sodium lauryl sulfate, sodium myristyl sulfate and sodium cetyl sulfate, sodium N-acyl glutamate such as sodium N-lauroyl glutamate, sodium N-palmitoyl glutamate, and N-lauroyl. N-acyl sarcosine sodium, such as sarcosine sodium, N-myristoyl sarcosine sodium, N-methyl-N-acyl taurine sodium, N-methyl-N-acylalanine sodium, such as N-lauroylmethyl taurine sodium, N-myristoyl methyl taurine sodium Sodium laurylbenzene sulfonate, hydrogenated coconut fatty acid monoglyceride sodium monosulfate, sodium lauryl sulfoacetate, α-o Sodium fins sulfonate, lauryl POE sodium sulfate, sodium lauryl POE acetate, sodium lauryl POE phosphate, stearyl POE sodium phosphate and the like are used.

  Nonionic surfactants include glycerin fatty acid esters such as monoglyceryl stearate and decaglyceryl laurate, sugar fatty acid esters such as sucrose fatty acid ester, maltose fatty acid ester and lactose fatty acid ester, maltitol fatty acid ester, and lactitol fatty acid ester. Sugar alcohol fatty acid esters, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monostearate, polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil, myristic acid mono- or diethanolamide Fatty acid ethanolamide, sorbitan fatty acid ester, polyoxyethylene higher alcohol ether, polyoxyethylene polyoxy Propylene copolymer, polyoxyethylene polyoxypropylene fatty acid ester or the like is used.

  Zwitterionic surfactants include alkyldimethylaminoacetic acid betaines such as lauryldimethylaminoacetic acid betaine, N-alkyldiaminoethylglycine such as N-lauryldiaminoethylglycine, N-myristyldiaminoethylglycine, and N-alkyl-N-carboxyl. Methyl ammonium betaine, 2-alkyl-1-hydroxyethyl imidazoline betaine sodium and the like are used.

  Further, in the present invention, active ingredients include enzymes such as dextranase, mutanase, amylase, protease, superoxide dismutase, water-soluble polyphosphates such as potassium pyrophosphate, sodium tripolyphosphate, sodium metaphosphate, allantoin, dihydro Cholestanol, glycyrrhizic acid, glycyrrhetinic acid, ε-aminocaproic acid, tranexamic acid, bisabolol, isopropylmethylphenol, sodium chloride, triclosan, chlorhexidine salts, cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, ascorbic acid and its salts, tocopherol One or two or more active ingredients such as herbal extracts such as green grass, green grass, rosemary, clove, and thyme can be blended.

  The composition for tooth whitening of the present invention further includes perfumes such as anethole, carvone, peppermint oil, spearmint oil, preservatives such as benzoic acid and its sodium salt, parabens, red No. 3, red No. 104, yellow 4 No. 1, Blue No. 1, Green No. 3, mica titanium, a pigment or coloring agent such as petite, sweeteners such as saccharin and its sodium salt, stevioside, glycyrrhizin, aspartame and the like.

  The pH of the tooth whitening composition is not particularly limited as long as it is within the range of safety in the oral cavity and human body. Desirably, the tooth whitening composition is diluted 10 times with purified water. The pH is 4-10, more preferably the pH is 5.5-9. When the pH is less than 4, there is a concern of decalcification depending on the application time, and when the pH exceeds 10, when the gingiva is touched, there is a concern such as mucosal detachment. As pH adjusters, acetic acid, hydrochloric acid, sulfuric acid, nitric acid, citric acid, phosphoric acid, sodium hydroxide, potassium hydroxide, sodium acetate, sodium carbonate, sodium citrate, sodium hydrogen citrate, sodium phosphate, sodium hydrogen phosphate Etc. may be blended.

  The tooth whitening composition is prepared in the form of a paste, gel, liquid, etc., but depending on the form, it is preferably applied together with an application tool dedicated to holding and fixing to the tooth, The application tool dedicated to holding and fixing the tooth used in combination with the tooth whitening composition of the present invention assists the reliable application and fixing of the tooth whitening composition to the tooth, and the tooth in use Suppresses elution of the whitening composition into the gingiva, tongue and oral mucosa, prevents unpleasant feeling of use and induction of saliva, and further dilutes the tooth whitening composition by saliva intrusion, occlusion, chewing and other physical stimuli Used to prevent detachment from teeth. The material and shape of the tool are not particularly limited as long as the above object can be achieved, but tapes, sheets, films, mouth trays, mouthpieces, sponges, impression materials, pack materials made of water-insoluble materials, Alternatively, a tooth cover molded into a dentition is preferably used.

  The thickness of the application tool is preferably 0.01 to 5 mm, which does not give a sense of incongruity when worn on the oral cavity, and is particularly preferably 0.01 to 2 mm for tapes, sheets and films.

  About the material of the above-mentioned tool, polyethylene, foamed polyethylene, polypropylene, foamed polypropylene, polyester, polyurethane, rayon, pulp, which has excellent fit when applied to the oral cavity and enables long-term application of the preparation by suppressing the generation of saliva One or more of cotton, silk, paper, polysaccharide film, metal foil and the like are preferably used, and polyethylene, foamed polyethylene, polypropylene, foamed polypropylene, polyester, polyurethane, rayon, poorly water-soluble pullulan film are particularly preferable. The poorly water-soluble pullulan film is a film of pullulan and is not included in the pullulan component (B). In addition, saliva generated in the mouth by making the material on the side in contact with the oral mucosa and tongue with a hydrophilic or highly water-absorbing material such as woven or non-woven fabric using rayon, pulp, cotton, silk, paper, etc. It is preferable because it absorbs and retains and is excellent in use feeling. In this case, by adhering the water-impermeable film such as polyethylene, polypropylene, polyester, polyurethane, etc. on the side holding the tooth whitening composition, it prevents adsorption and penetration of the tooth whitening composition to the application tool. You can also.

  On the other hand, trays or mouthpieces made of plastic resins such as silicone rubber and natural rubber, and thermoplastic resins such as vinyl acetate resin, acrylic resin, and ethylene-vinyl acetate copolymer have a high degree of freedom of deformation, and the user's teeth Since it is easy to fit to a row and a tooth shape, it has excellent adhesion and fixability, and is suitable for the purpose of applying a tooth whitening composition to a tooth for a longer time.

  Furthermore, when using a gel composition with low viscosity and low adhesiveness to teeth, a sponge impregnated with the preparation, or a water-absorbing resin such as rayon, cotton, pulp, etc. on the inside of the tooth cover, tray, etc. An appropriate amount of the gel composition can be applied to the teeth by spreading and continuing to bite.

  In addition, although the application frequency, time, etc. are selected suitably, it is 1-6 times a day normally, especially 1-3 times, 1-10 minutes once, especially 1-3 minutes.

EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In addition, all% in each example is the mass%. Moreover, the measurement of an average particle diameter, a weight average molecular weight, a number average molecular weight, and a nitrogen content is as above-mentioned in the following example. Moreover, in the following Examples and Comparative Examples, there is an example using a polylysine powder manufactured by Chisso Corporation. Since this is a 50% powder, the blending amount is shown as a pure component.
Preparation of Formulation All raw materials were weighed, put into a kneader, decompressed to 4 kPa, and mixed until the composition became uniform to prepare a tooth whitening composition. In addition, pH is measured with a pH meter (HM-26S, manufactured by Toa DKK Co., Ltd.) after 1 minute at 25 ° C. when diluted 10-fold with purified water, and becomes pH 5.5 to 9.0. If necessary, it was adjusted using sodium hydroxide or hydrochloric acid.

Preparation of sheet Heated polyethylene film (low density polyethylene, thickness 10 μm, manufactured by Tosoh Corporation, product grade; 212), polypropylene nonwoven fabric (100% polypropylene, spunbond, basis weight 40 g / m ² , surface embossing, Idemitsu Petrochemical Co., Ltd., product grade; Idemitsu RN2040) and rayon / polypropylene nonwoven fabric (rayon / polypropylene = 70/30, spun lace, basis weight 40 g / m ² , Shinwa Co., Ltd., product grade: 7140-6) A three-layer nonwoven fabric sheet having a thickness of 0.5 mm was produced by sandwiching and heat-sealing. Rayon / polypropylene nonwoven side of this three-layer nonwoven sheet and facing film (polyethylene terephthalate 100%, single-sided silicon coat, thickness 50 μm, manufactured by Toray Film Processing Co., Ltd., product grade; Therapy BK (S) # 50) The tooth whitening composition was coated between the silicon coated surfaces using a spreader (manufactured by Hanae Machinery Co., Ltd., roll sand coater) so that the total thickness was 1 mm. After that, the sheet coated with the tooth whitening composition was cut out so that the lip surface and the tongue surface of the left and right third to third teeth of the upper and lower jaws could be covered (60 mm × 25 mm). A sheet that can be attached to the dentition was prepared.

[Examples 1 to 10, Comparative Examples 1 to 4]
On the human extracted tooth whose color difference L ^* a ^* b ^* was measured in advance, a sheet coated with the composition shown in Table 1 by the above method was placed, and left in a constant temperature bath at 37 ° C. for 3 minutes. The sheet was peeled off, the gel was lightly wiped with a tissue, washed with water, and then transferred into artificial saliva. After immersion in artificial saliva for 3 hours, the color difference L ^* a ^* b ^* was measured to determine ΔE. The color difference was measured using a spectrocolorimeter (Minolta, CM-2022). The composition of artificial saliva is as follows.
Calcium chloride dihydrate 0.2205g
Potassium dihydrogen phosphate 0.6805g
Sodium chloride 5.8440g
Acetic acid 6.0g
NaOH (pH adjuster) appropriate amount
Water remaining
1,000 mL in total
Whitening effect ΔE ^* (1) = ((L ^* 1-L ^* 0) ² + (a ^* 1-a ^* 0) ² + (b ^* 1-b ^* 0) ² ) ^1/2
Persistence of whitening effect ΔE ^* (2) = ((L ^* 2-L ^* 0) ² + (a ^* 2-a ^* 0) ² + (b ^* 2-b ^* 0) ² ) ^1/2
Note that L ^* 0, a ^* 0, and b ^* 0 represent initial L ^* a ^* b ^* values. Similarly, L ^* 1, a ^* 1, b ^* 1, L ^* 2, a ^* 2, b ^* 2 the L ^* a ^* b ^* value after whitening operation respectively, the L ^* a ^* b ^* value after artificial saliva immersion.
Evaluation standard whitening effect A: ΔE ^* (1) is 7.0 or more
○: ΔE ^* (1) is 5.0 or more and less than 7.0
Δ: ΔE ^* (1) is 3.0 or more and less than 5.0
X: ΔE ^* (1) is less than 3.0 Persistence of whitening effect A: ΔE ^* (2) is 6.0 or more
○: ΔE ^* (2) is 4.0 or more and less than 6.0
Δ: ΔE ^* (2) is 3.0 or more and less than 4.0
X: ΔE ^* (2) is less than 3.0 The results are shown in Table 1.

[Example 11]
A foamed polyethylene sheet (Borara XL-IF08008 manufactured by Sekisui Chemical Co., Ltd., 15 mm x 60 mm) that covers the lip of the front teeth left 3 to right 3 with 2.0 g of the following tooth whitening composition 1 applied in advance. X thickness 800 μm) was applied to the labial surface of the tooth. When evaluated in the same manner as in Examples 1 to 10 and Comparative Examples 1 to 4, the whitening effect was ◎, and the sustainability of the whitening effect was ◎.
Tooth whitening composition 1 (paste)
Titanium dioxide 3.0%
(Ishihara Sangyo Co., Ltd. Taipei CR-50, average particle size 0.25 μm)
Pullulan (Hayashibara Corporation, PF-2, weight average molecular weight 200,000) 10.0
Polylysine (Chisso Corporation, polylysine powder, number average molecular weight 4400) 2.5
Sodium carboxymethylcellulose 0.5
(Daicel Chemical Industries, trade name CMC Daicel-1150)
70% sorbitol 30.0
Propylene glycol 3.0
Saccharin sodium 0.2
Methylparaben 0.1
Fragrance 1.0
Purified water balance
Total 100.0%

[Example 12]
Polyurethane film (made by Sea Dam Co., Ltd., DUS2124-CDB, 15 mm × 60 mm × thickness 50 μm), which is coated with 2.0 g of the following tooth whitening composition 2 in advance and covers the lip surfaces of the front teeth left 3 to right 3 ) Was affixed to the lips of the teeth. When evaluated in the same manner as in Examples 1 to 10 and Comparative Examples 1 to 4, the whitening effect was ◎ and the whitening effect persistence was ○.
Tooth whitening composition 2 (gel)
Titanium dioxide 4.0%
(Ishihara Techno Co., Ltd. TTO-51 (A), average particle size 0.02 μm)
Pullulan (Shoko Tsusho Co., Ltd., P-800, weight average molecular weight 790,000) 3.0
Cationized cellulose 0.3
(Japan NSC Co., Ltd., nitrogen content 2%, weight average molecular weight 300,000)
Xanthan gum 0.2
(Product name: Sanace NXG-S, manufactured by San-Ei Gen FFI Co., Ltd.)
Sodium polyacrylate 0.6
(Nippon Pure Chemicals, trade name Aronbis SS)
Butylparaben 0.1
70% sorbitol 23.0
Propylene glycol 5.0
Sodium benzoate 0.2
Fragrance 1.0
Purified water balance
Total 100.0%

[Example 13]
A polyethylene film (soft PE manufactured by Toray Industries, Inc., 10 mm × 15 mm × 25 μm thick) in which 0.2 g of the following tooth whitening composition 3 is applied in advance and each tooth is shaped Affixed only to the teeth. When evaluated in the same manner as in Examples 1 to 10 and Comparative Examples 1 to 4, the whitening effect was ◎, and the sustainability of the whitening effect was ◎.
Teeth whitening composition 3 (gel)
Zirconium oxide (Nippon Denko, N-PC, average particle size 0.02 μm) 0.5%
Titanium dioxide 3.0
(Ishihara Techno Co., Ltd. TTO-51 (A), average particle size 0.02 μm)
Pullulan (Shoko Tsusho Co., Ltd., P-400, weight average molecular weight 400,000) 5.0
Lysozyme (Wako Pure Chemical Industries, Ltd., lysozyme, molecular weight 14400) 0.1
Polylysine (Chisso Corporation, polylysine powder, number average molecular weight 4400) 1.5
Glycerin 15.0
Polyoxyethylene (60 mol) hydrogenated castor oil 1.0
Xanthan gum 0.2
(Product name: Sanace NXG-S, manufactured by San-Ei Gen FFI Co., Ltd.)
Sodium fluoride 0.2
Fragrance 1.0
Saccharin sodium 0.1
Purified water balance
Total 100.0%

[Example 14]
After applying the following tooth whitening composition 4 with a 1.0 g brush to the lip of the left third tooth to the right third tooth, a polypropylene film (soft PP made by Toray Industries, 15 mm x 60 mm x thickness) 100 μm) was affixed. When evaluated in the same manner as in Examples 1 to 10 and Comparative Examples 1 to 4, the whitening effect was ◎, and the sustainability of the whitening effect was ◎.
Teeth whitening composition 4 (liquid)
Aluminum oxide 2.0%
(Meller's product name: pure alumina powder, average particle size 0.06 μm)
Pullulan (Hayashibara Corporation, PF-2, weight average molecular weight 200,000) 3.0
Cationized cellulose 1.5
(Japan NSC Co., Ltd., nitrogen content 2%, weight average molecular weight 300,000)
Carrageenan 0.1
(Product name: GELRICH No. 3 manufactured by San-Ei Gen FFI Co., Ltd.)
Polyoxyethylene (60 mol) hydrogenated castor oil 1.0
Sodium benzoate 0.3
Methylparaben 0.1
Citric acid 0.1
Sodium citrate 0.3
Fragrance 0.5
Saccharin 0.02
Purified water balance
Total 100.0%

[Example 15]
Mouthpieces made of ethylene vinyl acetate resin were warmed and softened with hot water and chewed to produce mouthpieces fitted to their respective tooth shapes. A mouthpiece was filled with 1.0 g of the following tooth whitening composition 5 and attached. When evaluated in the same manner as in Examples 1 to 10 and Comparative Examples 1 to 4, the whitening effect was ◎ and the whitening effect persistence was ○.
Tooth whitening composition 5 (gel)
Silicon dioxide 1.0%
(Manufactured by Huber, trade name Zeodent 113, average particle size 5.0 μm)
Pullulan (Shoko Tsusho Co., Ltd., P-50, weight average molecular weight 47,000) 5.0
Polylysine 1.2
(Wako Pure Chemical Industries, Ltd., poly L lysine hydrobromide, number average molecular weight of 300,000 or more)
Sodium carboxymethylcellulose 0.3
(Daicel Chemical Industries, trade name CMC Daicel-1150)
Carrageenan 0.2
(Product name: GELRICH No. 3 manufactured by San-Ei Gen FFI Co., Ltd.)
Sorbit 20.0
Xylit 10.0
Propylene glycol 3.0
Methylparaben 0.05
Fragrance 1.0
Saccharin sodium 0.15
Purified water balance
Total 100.0%

Claims (3)

(A) One or more selected from titanium dioxide, silicon dioxide, zinc oxide, aluminum oxide, magnesium oxide, zirconium oxide,
(B) Pullulan,
(C) A tooth whitening composition comprising one or more selected from lysozyme, cationized cellulose, and polylysine.   A tooth whitening composition according to claim 1, and an application tool that holds the tooth whitening composition and is detachably attached to a tooth while holding the tooth whitening composition. A set for teeth whitening.   The tooth whitening set according to claim 2, wherein the application tool is a tape, a sheet, a film, a mouth tray, a mouthpiece, a sponge, an impression material, a pack material, or a tooth cover molded into a dentition.