JP4851078B2 - Ultrasound imaging device - Google Patents

Description

  The present invention relates to an ultrasonic imaging apparatus that performs imaging of a subject into which a contrast medium is injected and detects the contrast medium using a time intensity curve.

  In recent years, a contrast agent is injected into a subject, and the subject is imaged using an ultrasonic imaging apparatus. Here, the contrast agent is made of a liquid containing a large number of micro bubbles. The liquid injected into the subject circulates in the body with time. At this time, the ultrasonic wave emitted from the ultrasonic imaging apparatus is strongly reflected by the microbubbles from the portion where the contrast medium circulates, and is received as an ultrasonic echo (echo) having a high signal intensity.

  Therefore, a time intensity curve (Time Intensity Curve: hereinafter abbreviated as TIC), which is the time change of the signal intensity, is generated in the region of interest on the contrast mode image such as the B mode, and the time change of the TIC is observed. Thus, the state of the circulation of the contrast agent in the subject is quantitatively grasped, and at the same time, the presence or absence or degree of the disease in the subject is determined (for example, see Non-Patent Document 1).

At this time, the operator manually sets a region of interest on the contrast mode image for acquiring the TIC. This region of interest is a region designated by a circular or rectangular outline displayed on the contrast mode image. The size and position of this area are set by the operator. Here, the size and position of the region of interest are increased for the purpose of noise reduction effect by averaging, while the size and position of the region of interest does not include non-uniform tissue are determined at the discretion of the operator. .
F. Moriyasu and 2 others, “Ultrasound Contrast Guidebook”, Kanehara Publishing, February 28, 2003, p. 54-55

  However, according to the background art described above, the operator cannot acquire detailed information in the set region of interest. In other words, since the TIC is generated based on the image information averaged in the region of interest, the detailed information in the region of interest disappears.

  In particular, the region of interest includes a plurality of tissues, such as a tissue shape and noise in a single tissue in the case of a single tissue, and this information is used for diagnosis of the subject or the position of the region of interest and This is useful information for setting the size.

For these reasons, when acquiring a TIC, it is important how to realize an ultrasonic imaging apparatus that allows an operator to recognize detailed information in a set region of interest.
The present invention has been made to solve the above-described problems caused by the background art, and provides an ultrasonic imaging apparatus that allows an operator to recognize detailed information in a set region of interest when acquiring a TIC. With the goal.

  In order to solve the above-described problems and achieve the object, an ultrasonic imaging apparatus according to a first aspect of the invention sets a region of interest on a contrast mode image of a subject, and averages the region of interest. An ultrasonic imaging apparatus for obtaining a time intensity curve indicating a time change in signal intensity, a statistical information calculation means for calculating statistical information in a region of interest at each data point position where the time change occurs, and the data point position Alternatively, there is provided statistical additional information display means for displaying the statistical information as the time intensity curve additional information in the vicinity of the data point position.

  The ultrasonic imaging apparatus according to the invention of the second aspect is characterized in that, in claim 1, the statistical information is a dispersion of signal intensity of a contrast mode image included in the region of interest.

  The ultrasonic imaging apparatus according to the invention of the third aspect is the ultrasonic imaging apparatus according to claim 1 or 2, wherein the statistical information is a maximum value and a minimum value of a signal intensity included in a contrast mode image included in the region of interest. It is characterized by.

  An ultrasonic imaging apparatus according to a fourth aspect of the present invention is the ultrasonic imaging apparatus according to any one of claims 1 to 3, wherein the additional information is displayed in an overlapping manner with the data point position. It is a bar wire in an orthogonal direction.

  An ultrasonic imaging apparatus according to a fifth aspect of the present invention is the ultrasonic imaging apparatus according to any one of claims 1 to 4, wherein the additional information forms the time intensity curve located in the vicinity of the data point position. It is characterized by the thickness of the curve.

  An ultrasonic imaging apparatus according to the invention of a sixth aspect according to any one of claims 1 to 5, wherein the additional information forms the time intensity curve located in the vicinity of the data point position. It is characterized by the color of the curve.

  The ultrasonic imaging apparatus according to the seventh aspect of the invention is characterized in that, in claims 2 and 4, the statistical additional information display means includes the bar wire having a length proportional to the size of the dispersion. And

  The ultrasonic imaging apparatus according to the invention of the eighth aspect is the bar according to claim 3 and 4, wherein the statistical additional information display means has an end point at a signal intensity position coinciding with the maximum value and the minimum value. It is characterized by providing.

  The ultrasonic imaging apparatus according to the ninth aspect of the invention is characterized in that, in claims 2 and 5, the statistical additional information display means includes the curve having a thickness proportional to the size of the variance. To do.

  An ultrasonic imaging apparatus according to a tenth aspect of the invention is the ultrasonic imaging apparatus according to claims 3 and 5, wherein the statistical additional information display means determines the maximum value, the minimum value, or the difference between the maximum value and the minimum value. The curve having a proportional thickness is provided.

  The ultrasonic imaging apparatus according to an eleventh aspect of the invention is characterized in that, in claims 2 and 6, the statistical additional information display means includes the curve of a color reflecting the size of the dispersion. .

  An ultrasonic imaging apparatus according to a twelfth aspect of the invention is the ultrasonic imaging apparatus according to claims 3 and 6, wherein the statistical additional information display means calculates the maximum value, the minimum value, or the difference between the maximum value and the minimum value. It is characterized by comprising the curve of the color to reflect.

  An ultrasonic imaging apparatus according to a thirteenth aspect of the present invention is the input unit for setting a data point position for performing the calculation and the display in the ultrasonic imaging apparatus according to any one of claims 1 to 12. It is characterized by providing.

  As described above, according to the present invention, the statistical information calculation means calculates the statistical information in the region of interest at each data point position that changes with time, and the statistical additional information display means calculates the data point position or the data point position. Since the statistical information is displayed as additional information of the time intensity curve in the vicinity of the operator, the operator performs differential diagnosis using this additional information as supplementary information or determines whether the set region of interest is appropriate. The differential diagnosis or time intensity curve can be made highly reliable.

The best mode for carrying out an ultrasonic imaging apparatus according to the present invention will be described below with reference to the accompanying drawings. Note that the present invention is not limited thereby.
FIG. 1 is a block diagram showing the overall configuration of the ultrasound imaging apparatus according to the present embodiment. The ultrasonic imaging apparatus includes a probe unit 101, a transmission / reception unit 102, an image processing unit 103, a cine memory unit 104, an image display control unit 105, a TIC processing unit 109, a display unit 106, an input unit 107, and a control. Part 108.

  The probe unit 101 repeatedly irradiates ultrasonic waves in a part for transmitting / receiving ultrasonic waves, that is, a specific direction of the living body, and receives ultrasonic signals repeatedly reflected from inside the living body as time-series sound rays. On the other hand, the probe unit 101 also performs electronic scanning while sequentially switching the irradiation direction of ultrasonic waves. Although not shown in the figure, piezoelectric elements are arranged in the probe unit 101 in an array.

  The transmission / reception unit 102 is connected to the probe unit 101 by a coaxial cable, and generates an electrical signal for driving the piezoelectric element of the probe unit 101. Further, the transmission / reception unit 102 performs first-stage amplification of the received ultrasonic signal.

  The image processing unit 103 performs contrast mode processing for generating a contrast mode image for rendering a contrast agent in real time from the ultrasound signal amplified by the transmission / reception unit 102. Specific processing contents include, for example, delay addition processing of received ultrasonic signals, A / D (analog / digital) conversion processing, and digital information after conversion in the cine memory unit 104 described later as contrast mode image information. For example, a writing process. Contrast mode images include those using a contrast mode image, a harmonic mode image, a color doppler mode image, a power doppler mode image, or the like. Is selected and used to depict the contrast medium.

  The cine memory unit 104 is an image memory for storing the contrast mode image information generated by the contrast mode processing. In particular, contrast mode image information that changes over time is stored for each frame with a time-series index, and is used as basic data for later analysis of temporal changes in image information.

  The image display control unit 105 converts the display mode rate (frame rate) of the contrast mode image information generated by the image processing unit 103 and the flow information generated by the Doppler process, and the display unit 106 for the contrast mode image information and the like. Control the shape and display position of the display image. In addition, a region of interest (ROI) indicating a region of interest on a display image such as contrast mode image information is also displayed.

  The display unit 106 uses a CRT (Cathode Ray Tube) or LCD (Liquid Crystal Display) or the like to display the display frame rate conversion and image display shape and position controlled information to the operator by the image display control unit 105. Visible display. FIG. 2 is an example of a display screen displayed on the display unit 106. A contrast mode image 210 is displayed on the left side of the screen, and an ROI 212 is set on the contrast mode image 210. A TIC image 220 is displayed on the right side of the screen, and the TIC 220 at the position of the ROI 212 is displayed. The TIC 220 is attached with additional information to be described later.

  Returning to FIG. 1, the input unit 107 includes a keyboard, a pointing device, and the like. The operator selects image information displayed on the display unit 106 and functions such as Doppler processing from the input unit 107 and transmits these operation input signals to the control unit 108. In addition, the position setting of the ROI located on the contrast mode image of the display unit 106 and the confirmation input of the ROI position are also performed.

  Based on the image information accumulated in the cine memory unit 104 and the ROI position information on the contrast mode image 210 determined by the input unit 107, the TIC processing unit 109 performs TIC at the ROI position of the contrast mode image 210, that is, time intensity. Generate a curve. Here, the TIC has a shape like the TIC 222 shown in FIG. 2, for example. The TIC 222 is a curve displayed on the screen with the horizontal axis representing the time axis and the vertical axis representing the signal intensity, and the signal intensity increases in synchronization with the time when the contrast agent flows into the ROI 212 position.

  The control unit 108 controls the operation of each unit of the above-described ultrasonic imaging apparatus based on the operation input signal given from the input unit 107 and the program (program) and data (data) stored in advance, and displays the contrast on the display unit 106. A mode image, a TIC image, etc. are displayed.

  FIG. 3 is a functional block diagram showing a functional configuration of the TIC processing unit 109. The TIC processing unit 109 includes an ROI extraction unit 111, a signal intensity average calculation unit 112, a statistical information calculation unit 115, and a statistical additional information display unit 120. The statistical additional information display unit 120 includes a statistical statistical additional information generation unit 122 and an attachment unit 121.

  The ROI extraction unit 111 is configured to obtain image information of the ROI 212 portion from a plurality of time-series contrast mode images stored in the cine memory unit 104 based on positional information of the ROI 212 set in the contrast mode image 210 from the control unit 108. Are extracted sequentially. Then, from the extracted image information, for example, a frequency distribution for each signal intensity as shown in FIG. 4 is obtained. FIG. 4 is an example of a frequency distribution indicated by the signal intensity of the ROI 212 part. The horizontal axis indicates the signal intensity that is the pixel value, and the vertical axis indicates the frequency that is the number of pixels in the ROI 212 having this signal intensity.

  The signal strength average calculation means 112 obtains an average value of signal strength from the frequency distribution obtained by the ROI extraction means 111. This is a value indicated by an average value in FIG. 4 and is located in the vicinity of the signal intensity having the highest frequency, and is a value representative of the signal intensity of the ROI extraction unit 111. Then, the signal intensity average calculating means 112 averages the ROI 212 portion for each frame of a plurality of time-series contrast mode images stored in the cine memory unit 104, and the TIC information for each data point position on the time axis. Is generated. This TIC information includes information on a curve such as TIC 222 shown in FIG.

  The statistical information calculation unit 115 calculates the signal strength statistical information from the frequency distribution obtained by the ROI extraction unit 111. The statistical information is an amount such as a variance σ, a maximum value, or a minimum value when the frequency distribution is approximated by a Gaussian distribution as shown in FIG. These amounts are set by the operator from the input unit 107 and input to the TIC processing unit 109 via the control unit 108.

  The statistical additional information display unit 120 includes a statistical additional information generation unit 122 and an attachment unit 121, and displays the TIC information with the statistical information attached as additional information. The statistical additional information generation unit 122 generates additional information set by the control unit 108 according to the size of the statistical information. Here, the additional information is a means for expressing statistical information on the curve of the TIC 222, and is the length of the vertical bar line displayed over the data point position forming the TIC 222, and the thickness of the curve forming the TIC 222. Or the color of the curve forming the TIC 222. The additional information is set from the input unit 107 by the operator and input to the TIC processing unit 109 via the control unit 108.

  The statistical additional information generation unit 122 reflects the size of the statistical information in the length of the bar, the thickness of the curve, or the color described above. For example, when the statistical information is variance and the additional information is a bar, attached information is generated that displays a bar with a length that matches the variance at the displayed data point position. In addition, when the statistical information is the maximum value or the minimum value and the additional information is a bar line, attached information for displaying a bar line connecting the maximum value or the minimum value from the average value at the displayed data point position is displayed. Generate. Further, when the statistical information is variance and the additional information is the thickness of the curve, the attached information for displaying the thickness of the curve proportional to the size of the variance is generated at the displayed data point position.

  The attaching unit 121 attaches the attached information generated by the statistical additional information generating unit 122 to the TIC information. In this attachment, the bar or curve information described above is attached to the TIC information as, for example, header information, and the image display control unit 105 forms and displays the TIC information including the attached information. Alternatively, the attachment unit 121 may generate TIC information including attachment information, and output the TIC information to the image display control unit 105 for display. These are preferably selected in accordance with the additional information.

  Next, the operation of the ultrasonic imaging apparatus according to this embodiment will be described with reference to FIG. FIG. 5 is a flow chart showing the operation of the ultrasound imaging apparatus according to the present embodiment. First, the operator injects a contrast medium into the subject (step S501). Then, simultaneously with the injection of the contrast agent, the operator acquires the contrast mode image information of the target region of the subject for a while (step S502). In synchronization with this, the control unit 108 stores the time-series contrast mode image information of the same part in the cine memory unit 104. Thereafter, the control unit 108 performs a TIC display process to be described later (step S503), and the TIC is added with statistical information. Then, the presence / absence or degree of the disease is examined based on the TIC to which the statistical information is added (step S504), and this process is terminated.

  FIG. 6 is a flowchart showing the operation of the TIC display process in step S503. The operator sets statistics from the input unit 107 (step S601). In this setting, statistics such as variance, maximum value or minimum value are set.

  Further, the operator sets additional information from the input unit 107 (step S602). In this setting, additional information such as a bar line at a data point position, thickness distribution of a curve or color is set.

  Thereafter, the operator sets the ROI 212 on the contrast mode image 210 of the imaging region displayed on the display unit 106 (step S603). Then, the TIC processing unit 109 acquires the pixel value information and the acquisition time information of the contrast mode image information from the corresponding position of the contrast mode image information stored in the cine memory unit 104 based on the set position information of the ROI 212. TIC information is obtained (step S604).

  After that, the TIC processing unit 109 calculates the statistical information of the ROI 212 for each data point position on the time axis set in advance (step S605). Then, the TIC processing unit 109 generates additional information from the statistical information for each data point position, and attaches the additional information to the TIC information (step S606).

  Thereafter, the control unit 108 displays the TIC information to which the additional information is attached on the display unit 106 (step S607), and returns to step S504 in FIG. FIG. 7 is an example of TIC information to which additional information is attached, which is displayed on the TIC image 220 of the display unit 106.

  FIG. 7A shows an example of the TIC image 220 when the variance σ is calculated as statistical information and a bar on the data point position is used as additional information. As shown in FIG. 7A, a bar line is displayed on the data point position having a predetermined interval, and the length of the bar line coincides with the size of the variance σ at the data point position. As shown in the enlarged view on the right side of FIG. 7A, this bar has a symmetrical shape with a length σ in the vertical direction of the data point position.

  FIG. 7B is an example of the TIC image 220 when the maximum value and the minimum value are calculated as statistical information and a bar line on the data point position is used as additional information. As shown in FIG. 7B, a bar line is displayed on the data point position having a predetermined interval, and the position of the end point of this bar line is the maximum value or the signal intensity in the ROI 212 at this data point position or It matches the size of the minimum value. Note that, as shown in the enlarged view on the right side of FIG. 7B, this bar can have different lengths in the vertical direction around the average value.

  FIG. 7C shows an example of the TIC image 220 when the variance σ is calculated as statistical information and the thickness of a curve representing the TIC 222 is used as additional information. As shown in FIG. 7C, the thickness of the curve representing the TIC 222 is proportional to the magnitude of the variance σ at this point. For example, in FIG. 7C, the dispersion is large at the rising portion of the TIC 222 and is a thick curve. As shown in the enlarged view on the right side of FIG. 7C, the thickness of this curve is proportional to the magnitude of the variance σ.

  Here, the operator can perform more preferable diagnosis or setting in the differential diagnosis of the tumor or the setting of the ROI by referring to the TIC 222 as shown in FIGS. In the differential diagnosis of the tumor, the statistical information shown in FIGS. 7A to 7C reflects the distribution of the tissue in the tumor, so that the operator complements, for example, when determining benign or malignant. It can be used as information.

  Further, in the ROI setting, the statistical information shown in FIGS. 7A to 7C reflects the magnitude of noise in the ROI or the number of tissues existing in the ROI. By resetting the size, it is possible to make the TIC 222 highly reliable or a single organization existing in the ROI.

  As described above, in the present embodiment, statistical information such as variance, maximum value or minimum value calculated from the set ROI 212 is added, for example, a bar or a curve thickness at the data point position. Since the information is attached to the TIC 222 and displayed, the operator refers to the TIC 222 including the statistical information as the TIC image 220 and determines whether the differential diagnosis or the set ROI 212 is appropriate. The differential diagnosis or TIC 222 can be made highly reliable.

  Further, in the present embodiment, an example is shown in which the bar thickness on the data point position or the thickness of the curve forming the TIC 222 is used as additional information, but this curve is displayed when the display unit 106 is in color display. Can also be a color that reflects the magnitude of the variance, maximum value or minimum value.

  In this embodiment, the statistical information and the additional information are calculated and displayed at the data point positions set in advance in the TIC. However, the data point positions for performing the calculation and display are set from the input unit 107. In this manner, calculation and display can be performed for each frame at the data point position, or conversely, for each frame at an arbitrary interval.

1 is a block diagram showing the overall configuration of an ultrasound imaging apparatus. It is explanatory drawing which shows the display screen displayed on the display part of embodiment. It is a functional block diagram which shows the functional structure of the TIC processing part concerning embodiment. It is a distribution map which shows the example of the frequency distribution of the contrast mode image information contained in ROI. It is a flowchart which shows operation | movement of an ultrasonic imaging apparatus. It is a flowchart which shows the operation | movement of the TIC display process of an ultrasonic imaging device. It is explanatory drawing which shows the example of the TIC image to which additional information was attached.

Explanation of symbols

DESCRIPTION OF SYMBOLS 101 Probe part 102 Transmission / reception part 103 Image processing part 104 Cine memory part 105 Image display control part 106 Display part 107 Input part 108 Control part 109 TIC processing part 111 ROI extraction means 112 Signal strength average calculation means 115 Statistical information calculation means 120 Statistics Additional information display means 121 Attachment means 122 Additional information generation means 210 Contrast mode image 220 TIC image

Claims (7)

An ultrasound imaging apparatus for setting a region of interest on a contrast mode image of a subject and displaying a time intensity curve indicating a temporal change in averaged signal intensity in the region of interest,
Statistical information calculation means for calculating statistical information including variance relating to signal intensity in the region of interest at a predetermined number of respective times corresponding to the time intensity curve;
The dispersion described above calculates, the display in the thickness of the curve forming the time intensity curves corresponding to the respective time statistics information display means and ultrasound imaging apparatus characterized by comprising a. An ultrasound imaging apparatus for setting a region of interest on a contrast mode image of a subject and displaying a time intensity curve indicating a temporal change in averaged signal intensity in the region of interest,
Statistical information calculation means for calculating statistical information including a maximum value and a minimum value related to signal intensity in the region of interest at a predetermined number of times corresponding to the time intensity curve;
An ultrasonic imaging apparatus comprising: statistical information display means for displaying the calculated maximum value and minimum value with a thickness of a curve forming the time intensity curve corresponding to each time. An ultrasound imaging apparatus for setting a region of interest on a contrast mode image of a subject and displaying a time intensity curve indicating a temporal change in averaged signal intensity in the region of interest,
Statistical information calculation means for calculating statistical information including a maximum value , a minimum value, or a variance regarding the signal intensity in the region of interest at a predetermined number of times corresponding to the time intensity curve;
An ultrasonic imaging apparatus comprising: statistical information display means for displaying the calculated maximum value , minimum value, or variance in a color of a curve forming the time intensity curve corresponding to each time. . The ultrasonic imaging apparatus according to any one of claims 1 to 3,
The statistical information obtaining means, in the time intensity curve number of each time a predetermined corresponding to the maximum value and the minimum value the calculated and calculates the maximum and minimum values for the signal strength of the ROI An ultrasonic imaging apparatus characterized by calculating a difference between the two . The ultrasonic imaging apparatus according to claim 4 .
The statistical information display means corresponds to the calculated maximum value, minimum value, or difference between the maximum value and the minimum value of each time, and a bar parallel to the axis indicating the signal intensity on the time intensity curve. An ultrasonic imaging apparatus characterized by displaying a line and changing the thickness or color of the curve forming the time intensity curve in accordance with the calculated variance of each time . The ultrasonic imaging apparatus according to claim 4 .
The statistical information display means displays a bar line parallel to the axis indicating the signal intensity on the time intensity curve in correspondence with the calculated variance of the respective times, and the calculated respective times. An ultrasonic imaging apparatus, wherein the thickness or color of the curve forming the time intensity curve is changed in correspondence with the maximum value, the minimum value, or the difference between the maximum value and the minimum value . The ultrasonic imaging apparatus according to any one of claims 1 to 6 ,
An ultrasonic imaging apparatus comprising: an input unit that sets the predetermined number of times for calculating the statistical information.

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