JP4814415B2 - Cosmetic composition - Google Patents

Description

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（処方例２９）被覆保護剤
ガーゼ又はリニメント布にセイヨウスノキ熱水抽出液，抗生物質，抗炎症剤などを適量混合した処方液を含浸させ、外傷部に添付する。又、セイヨウスノキ熱水抽出物を直接、局所に散布し、ガーゼ等で被覆しても良い。
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（試験９）使用効果試験
本発明の化粧料組成物を実際に使用した場合の効果について検討を行った。使用テストはシミ、ソバカス、色黒で悩む人３０〜６０歳の各１０名をパネラーとし、毎日、朝と夜の２回、洗顔後に処方例１の乳液の適量を顔面に３ヶ月に渡って塗布することにより行った。尚、対照には、乳液から本発明の各植物抽出物を除いたものを同様な方法にて処方したものを用いた。又、評価方法は下記の基準にて行い、結果は表１の通りで表中の数値は人数を表す。尚、使用期間中に皮膚の異常を訴えた者はなかった。
【０１４６】
「シミ・ソバカス＆皮膚色改善効果」
有 効：シミ・ソバカスや肌の色が白く改善された。
やや有効：シミ・ソバカスや肌の色が白く改善された。
無 効：使用前と変化なし。
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〈表１〉

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（試験結果）
表１の通り、本発明のセイヨウスノキ抽出物を含有した化粧料組成物は、有意にシミ、ソバカスを改善し、又、肌の色も白く改善することが確認できた。
【０１４９】
（試験１０）使用効果試験
本発明の美肌化粧料組成物を実際に使用した場合の効果について検討を行った。使用テストはツヤ・張りのない肌及び又は湿疹・ニキビ・肌荒れで悩む人、３０〜５０歳の各１０名をパネラーとし、毎日、朝と夜の２回、洗顔後に処方例１の乳液の適量を顔面に３ヶ月に渡って塗布することにより行った。尚、対照には、乳液から本発明の各植物抽出物を除いたものを同様な方法にて処方したものを用いた。又、評価方法は下記の基準にて行い、結果は表２及び表３の通りで表中の数値は人数を表す。尚、使用期間中に皮膚の異常を訴えた者はなかった。
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「皮膚感触改善効果」
有 効：肌のツヤ・張りが増した。
やや有効：肌のツヤ・張りがやや増した。
無 効：使用前と変化なし。
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〈表２〉

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「湿疹・肌荒れ改善効果」
有 効：湿疹、ニキビ、肌荒れが改善された。
やや有効：湿疹、ニキビ、肌荒れがやや改善された。
無 効：使用前と変化なし。
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〈表３〉

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（試験結果）
表２及び３の通り、本発明の本発明のセイヨウスノキ抽出物を含有した化粧料組成物は、肌のツヤ・張りが増し、又、湿疹・ニキビ・肌荒れを改善することが確認された。
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【発明の効果】
本発明のセイヨウスノキ抽出物を含有したメラニン生成抑制剤、活性酸素消去剤、過酸化脂質生成抑制剤、リパーゼ活性抑制剤、抗アレルギー剤、ヒスタミン遊離抑制剤又は化粧料組成物は、メラニン色素の生成を有意に抑え、美白効果を有すること。又、活性酸素も有意に消去・抑制すること、又、過酸化脂質の生成又はリパーゼ活性を抑制すること。更に、ヒスタミン遊離抑制作用を確認した。
そして、シミ、ソバカスを改善し、肌の色を白く改善すること。又、湿疹・ニキビ・肌荒れを改善すること、更に肌のツヤ・張りも与えることができ、人・動物に対しても安全なものである。尚、本発明は、その他一般的な飲食品類への利用も可能である。
【図面の簡単な説明】
【図１】本発明のセイヨウスノキ抽出物のメラニン生成抑制作用を示す図である。
【図２】本発明のセイヨウスノキ抽出物の活性酸素消去作用を示す図である。
【図３】本発明のセイヨウスノキ抽出物の過酸化脂質生成抑制作用を示す図である。
【図４】本発明のセイヨウスノキ抽出物のリパーゼ活性抑制作用を示す図である。
【図５】本発明のセイヨウスノキ抽出物のヒスタミン遊離抑制作用を示す図である。[0001]
BACKGROUND OF THE INVENTION
The present invention relates to an application to a melanin production inhibitor, active oxygen scavenger, lipid peroxide production inhibitor, lipase activity inhibitor, antiallergic agent, histamine release inhibitor or cosmetic composition containing a cypress extract. Is.
[0002]
The field of use can be used in various external preparations (including preparations used for animals) in general, specifically, ampoules, capsules, pills, tablets, powders, granules, solids, liquids, gels Or 1) pharmaceuticals, 2) quasi-drugs, 3) topical or systemic skin cosmetics (for example, basic cosmetics such as lotions, emulsions, creams, ointments, lotions, oils, packs, etc.) Facial cleanser, skin cleanser, massage agent, cleansing agent, hair remover, hair remover, shaving treatment, after shave lotion, pre-show lotion, shaving cream, foundation, lipstick, blusher, eye shadow, eyeliner, mascara Makeup cosmetics such as, perfumes, beauty nails, beauty nail enamel, beauty nail enamel remover, poultice, plaster, tape, sheet, patch, Azoles, etc.), 4) medicinal and / or cosmetic preparations applied to the scalp and hair (eg shampoos, rinses, treatments, permanent solutions, hair dyes, hair styling agents, hair styling agents, hair growth and nourishment) Hair, poultices, plasters, tapes, sheets, patches, aerosols, etc.), 5) bathing agents used in bath water, 6) other anti-smell and deodorants, deodorants, hygiene Goods, sanitary cotton, wet tissue, fresheners in mouth (for example, toothpaste, mouthwash, etc.).
[0003]
[Prior art]
Factors that determine human skin color include the amount of melanin in the epidermis, blood flow in capillaries, food-derived pigments (carotene), and the thickness of the stratum corneum. One is melanin pigment. The so-called liver spots (spots), sparrow eggs (sobacus), and skin pigmentation after sunburn are markedly enhanced production of melanin pigments due to the activation of pigment cells in the skin. It has become one of the major skin problems for women.
[0004]
This melanin pigment is produced by melanosomes, which are organelles in pigment cells (melanocytes) present in the basal layer of the epidermis, the hair root, and the outer root sheath. In the process of melanin pigment formation, tyrosinase acts on tyrosine in pigment cells (melanocytes) to oxidize tyrosine, convert it into dopa and dopaquinone, and further auto-oxidize and polymerize via dopachrome and 5,6-dihydroxyindole. Finally, it becomes a melanin pigment. The produced melanin is secreted from the dendrites of pigment cells (melanocytes) to the basal cells, and the basal cells divide and become spiny cells, then rises, reaches the stratum corneum, and then drops off with detachment of the stratum corneum. It is supposed to go.
[0005]
Therefore, in order to prevent or improve skin spots (spots), sparrow eggspot (sobacus) and darkness, inhibit the melanin production process. Alternatively, it is conceivable to lighten already produced melanin. Therefore, various whitening components have been proposed based on these ideas. For example, kojic acid or its derivative, ascorbic acid or its derivative, tocopherol or its derivative, glutathione, hydrogen peroxide, zinc peroxide, hydroquinone monobenzyl ether, placenta extract, silk extract or plant extract (Arnica, Altea, Aloe , Ogon, Enmezo, Chamomile, Licorice, Gardenia, Gennoshouko, Sikon, Shouma, Birch, Senkyu, Genokosho, Psycho, Wildflower, Toki, Tokinsenka, Elderflower, Safflower, Garlic, Scallop, Ganoderma, Logwood), etc. It was.
[0006]
In recent years, the production of active oxygen in the living body and various effects (diseases) caused thereby have been reported. In general, this active oxygen is also called Activated oxygens.^2-, H₂O₂, OH, and chemiluminescence, each of which has a strong bactericidal action and is regarded as an important substance involved in the self-defense of living organisms. Enter the body, neutrophils, monocytes, and macrophages, which are phagocytes in the blood, start phagocytosis, and then lyse the phagocytic foreign bodies in the phagocytic vesicles. For this reason, active oxygen is produced, and this produced active oxygen not only dissolves sputum food, but on the other hand, it directly kills and protects against foreign enemies such as bacteria and foreign substances. Playing a role. In other words, it has the function of eliminating antigenic substances before the immune function is activated.
[0007]
However, if this active oxygen for self-protection is excessively produced and secreted, even normal cells are lysed and stimulated, resulting in various disordered reactions. Recently, many diseases and illnesses induced by active oxygen have been reported. For example, fats and oils such as cholesterol in the blood are oxidized by active oxygen, and blood vessels are damaged by arteriosclerosis in the brain and heart (stroke, myocardial infarction, etc.) It is said to cause blood flow disorder due to thrombus and the like, and ischemia in blood vessels due to rapid temporary atrophy during the brain trauma, resulting in an oxygen deficient state. Therefore, in this state, the xanthine dehydrogenase in the blood vessel is changed to xanthine oxidase, and a large amount of active oxygen is generated in the blood in the blood vessel, causing damage to the blood vessel wall and causing fatal damage. Yes.
[0008]
As for the relationship between the skin and active oxygen, for example, since the skin is an organ that directly contacts the outside world, the active oxygen continues to be excessive in the skin due to ultraviolet rays, radiation, etc. while being susceptible to environmental factors. Then, it reacts with the unsaturated fatty acid of the biological membrane phospholipid and lipid peroxide is produced. The generated lipid peroxide causes arteriosclerosis, carcinogenesis, aging, membrane destruction, protein denaturation and the like, and also causes skin inflammation, edema, wrinkles and the like. Furthermore, as a disease caused by excess of active oxygen, from a cosmetic viewpoint, for example, herpes dermatitis, X-ray dermatitis, burns, trauma, solar dermatitis, contact dermatitis, eczema, atopic dermatitis, etc. Therefore, in order to prevent or ameliorate various diseases so far, for example, in the living body of animals and plants, superoxide is required. Dismutase (SOD), catalase, glutathioperoxidase, and others, tocopherol (vitamin E), oryzanol, plant extract (hamamelis, melissa, birch, birch, sage, rosemary, ages, basil, ginkgo, psycho, peonies, hanger, Keihi, Taiso, Ogon, carrot, licorice, ginger) etc. were usedExamples of the lipid peroxide production inhibitor include β-carotene, plant extracts (sesame culture cells, sweet potatoes, hypericum, hamamelis, melissa, birch, birch, sage, rosemary, nanzenji, agetsu, ginkgo, green tea). It was known.
[0009]
Furthermore, acne vulgaris (acne), which can be particularly common from adolescence to adolescence, is one of the major skin problems regardless of gender. There are two main stages in the development of acne vulgaris. First, the plugs (keratinized and sebum mass) clog the sebaceous hair follicles, and comedo. Occurs. At this time, the comed is non-inflammatory, but then turns into an inflammatory rash that is difficult to treat, such as papules, pustules, and cysts.
[0010]
The cause of this occurrence is deeply related to three factors: endocrine factor (enhancement of sebaceous gland function), bacterial factor (propionibacterium acnes growth), and keratinization factor (keratoinjury of hair funnel). It is said that inhibition of lipase activity is greatly involved in one factor (bacterial factor).
[0011]
That is, as the early stage of acne generation, when sebum secretion is activated / increased, Propionibacterium acnes produces enzymes such as hyaluronidase and protease in addition to lipase. Lipase also hydrolyzes triglycerides in sebum to produce free fatty acids. This free fatty acid stimulates the hair follicle wall, promotes keratinization, and promotes the formation of comeds. Furthermore, hyaluronidase and protease stimulate and destroy the follicle wall of comed (face), forming inflammatory acne such as papules and pustules. However, by inhibiting the activity of lipase, the production of free fatty acids, the inhibition of keratinization damage, and the formation of comedo (surface) are suppressed, and sebum secretion is rapidly secreted into the epidermis. Become.
[0012]
On the other hand, allergies such as hay fever, allergic rhinitis, bronchial asthma, atopic dermatitis, drug urticaria, etc. due to recent deterioration of environmental conditions, changes in lifestyle, and increased stress accompanying social life complexity An increasing number of people suffer from illnesses, rough skin, and dry skin. In particular, atopic dermatitis has been attracting attention as one of the modern diseases because its increase has been screamed in a wide range of ages ranging from children to adults.
[0013]
Originally, in order to eliminate foreign substances (bacteria, pollen, ticks, etc .: antigen) that have entered the body, the immune system that works to protect the body by producing biological components (antibodies, lymphocytes, etc.) against it It has a function. However, sometimes the reaction becomes so sensitive that it can be harmful to the body and cause various diseases. This disordered response due to immune function is called allergy and is classified into four types.
[0014]
The central cell constituting the immune system is a group of two types of lymphocytes called B cells and T cells that exist mainly in bone marrow, thymus, spleen, lymph nodes, blood and the like. B cells are involved in humoral immunity (types I to III allergy), and in response to antigens, differentiate and proliferate into plasma cells (antibody producing cells), and secrete antibodies outside the cells. T cells are mainly involved in cellular immunity (type IV allergy). When they react with antigens, they become activated T cells that differentiate, proliferate, and destroy antigens.
[0015]
Type I allergic reactions are the most frequently occurring type, and mainly involve immunoglobulin E (IgE) antibodies. The onset process is the first stage in which IgE antibody is produced from B cells against foreign antigens, and IgE antibody adheres to mast cells and basophils. The second stage in which chemical mediators such as histamine, serotonin, and SRS-A are released from the body, the released chemical mediator causes smooth muscle contraction, increased vascular permeability, edema, nerve stimulation, etc. It is roughly divided into the third stage in which allergic symptoms are manifested.
[0016]
Type II allergic reaction is a disordered reaction caused by destruction of tissue cells by IgG and IgM antibodies. When an antibody binds to an antigen cell, the complement system (a system of serum proteins that is activated by the effector action of the antibody and kills the antigen cell or significantly accelerates the degradation of the antigen by phagocytes) is linked and activated. The cells are destroyed because a complex that breaks the cell membrane is formed. In addition, when activated components of the complement system bind to cells, antigen cells are captured, decomposed, and removed by phagocytic cells such as polymorphonuclear leukocytes and macrophages. On the other hand, in the process of activation of the complement system, a substance called anaphylatoxin having an action of remarkably accelerating the degradation of antigens by phagocytes is generated. This also has the effect of increasing the permeability of capillaries, the effect of contracting smooth muscles, and the effect of releasing histamine from mast cells. Therefore, if it is produced in excess, various allergic symptoms will appear.
[0017]
Type III allergic reactions are mainly caused by IgG antibodies, but their onset occurs by a complex mechanism involving many factors such as the complement system and polymorphonuclear leukocytes. Antigen-antibody conjugates produced by binding antibodies to antigens are deposited in tissues such as blood vessels, kidneys, joints, and skin to activate the complement system. When the amount of conjugate is high, the complement system is over-activated to produce anaphylatoxins, which increases inflammation and causes inflammation. In addition, when phagocytic cells work to remove antigen-antibody conjugates due to the action of anaphylatoxin, lysosomal degranulation occurs, and many types of hydrolases such as protease in the lysosome are released outside the cell. Tissue and cell damage progresses and type III allergy develops.
[0018]
All types I to III allergic reactions are due to humoral immunity, appearing in 2 to 3 minutes after contact with the antigen, and the reaction is highest in 10 minutes, so it is called immediate type, whereas type IV Allergic reactions appear after a few hours and are called delayed allergies because it takes 48-72 hours to reach a maximum. This allergic reaction is a reaction due to cellular immunity. A part of T cells reacts with an antigen to become activated T cells. When this reacts with the antigen again, various inflammatory factors (macrophage chemotactic factors, Lymphocyte migration factor, macrophage activation factor, vascular permeability factor, etc.). These work to eliminate antigens, but if this reaction proceeds excessively, allergies develop as a disordered reaction.
[0019]
Various test methods have been proposed according to the allergic reaction types classified as described above, and approaches to factors effective in preventing or ameliorating allergic diseases have been actively conducted so far.
[0020]
[Problems to be solved by the invention]
However, the above-mentioned whitening ingredients, active oxygen scavenging substances, and lipid peroxide production inhibiting substances have poor stability and solubility in the prescription system, cause off-flavor and coloring due to starch and decomposition, and are effective at the living body level. In addition, there were problems in terms of safety, such as causing skin irritation, which was not satisfactory.
[0021]
In addition, as external preparations effective for acne treatment, keratolytic agents (resorcin, salicylic acid, lactic acid, etc.), anti-seborrheic agents (pyridoxine or derivatives thereof, sulfur, vitamin B6, etc.), antibacterial agents, anti-inflammatory agents, etc. Although there are no known substances having a lipase activity-inhibiting action, the present situation is that.
[0022]
Furthermore, many of the antiallergic agents that have been used in the past are drugs related to diseases caused by immediate allergic reactions whose action points are relatively clear. For example, for type I allergies, antispasmodics that relax smooth muscles, sympathomimetic drugs that suppress increased permeability of capillaries, and antihistamines, etc., are all listed. It is a drug that acts on the stage and is effective as a symptomatic treatment, but most of them are synthetic drugs and have problems in terms of side effects. Furthermore, although research is actively conducted on the development of drugs effective for type II to type III allergies, no specific antiallergic agent has yet been found.
[0023]
[Means for Solving the Problems]
In view of such circumstances, the present inventors have developed a useful plant having a melanin production inhibitory action, an active oxygen scavenging (SOD) action, a lipid peroxide production inhibitory action, a lipase activity inhibitory action, and an antiallergic action (histamine release inhibitory action). As a result, the cypress extract significantly suppresses the formation of melanin pigment and has a whitening effect, and also significantly eliminates and suppresses active oxygen, and also generates lipid peroxide or lipase. Suppressed activity, confirmed histamine release inhibitory effect, improved stains and buckwheat, improved whiteness of skin, improved eczema, acne, rough skin, and glossy skin -Highly safe melanin production inhibitor that can give tension, active oxygen scavenger, lipid peroxide production inhibitor, lipase activity inhibitor, antiallergic agent, It has to provide a Sutamin release inhibitor or cosmetic composition, and have completed the present invention.
[0024]
DETAILED DESCRIPTION OF THE INVENTION
As used herein, the term “Apiaceae” refers to plants of Ericaceae and Vaccinium: flowers, spikes, pericarps, fruits, stems, leaves, branches of Vaccinium myrtillus L. Branches, leaves, stems, bark, rhizomes, root barks, roots, seeds, or whole grasses are used, but the genus cypress (V. smallii A. Gray var glabrum Koidz.) Can also be used.
[0025]
The cypress extract used in the present invention refers to various parts of plants (flowers, flower spikes, fruit skin, fruits, stems, leaves, branches, branches and leaves, trunks, bark, rhizomes, root barks, roots, seeds, whole plants, etc. ) Extracted as is or after crushing. Alternatively, it is extracted as it is or after pulverization with a solvent.
[0026]
Examples of the extraction solvent include water, alcohols (for example, lower alcohols such as methanol, absolute ethanol, and ethanol, or polyhydric alcohols such as propylene glycol and 1,3-butylene glycol), ketones such as acetone, ethyl ether, and dioxane. , Esters such as acetonitrile and ethyl acetate, and organic solvents such as xylene, benzene and chloroform can be used alone or in any combination of two or more, and the solvent extracts are combined. But you can use it.
[0027]
The production method is not particularly limited, but is usually within the range of the boiling point of the solvent at normal temperature and normal pressure. After extraction, filtration or ion exchange resin is used for adsorption, decolorization, and purification. A solution, paste, gel, or powder may be used. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decoloration may be added as long as the effect is not affected. An activated carbon column or the like may be used, and usual means generally applied depending on the extracted substance may be arbitrarily selected.
[0028]
The cypress extract is a melanin production inhibitor, active oxygen scavenger, lipid peroxide production inhibitor, lipase activity inhibitor, antiallergic agent, histamine release inhibitor or cosmetic composition dosage form / form. May be prepared by arbitrarily drying, concentrating, diluting, or the like.
[0029]
The cypress extract of the present invention can be contained in a melanin production inhibitor, an active oxygen scavenger, a lipid peroxide production inhibitor, a lipase activity inhibitor, an antiallergic agent, a histamine release inhibitor or a cosmetic composition. The amount is not particularly specified, but the melanin production inhibitor, active oxygen scavenger, lipid peroxide production inhibitor, lipase activity inhibitor, antiallergic agent, histamine release inhibitor or cosmetic composition type and quality Depending on the degree of expected action, it is usually 0.001% by weight or more (hereinafter expressed as%), preferably 0.2 to 20%. If the content is less than 0.001%, the effect cannot be expected sufficiently.
[0030]
  The melanin production inhibitor, active oxygen scavenger, lipid peroxide production inhibitor, lipase activity inhibitor, antiallergic agent, histamine release inhibitor or cosmetic composition of the present invention is necessary in addition to the above essential components. As long as the effects of the present invention are not impaired, the components and additives exemplified below are arbitrarily selected and used in combination.Can be manufactured.
[0031]
(1) Various fats and oils
Avocado oil, almond oil, fennel oil, egoma oil, olive oil, orange oil, orange rafa oil, sesame oil, cacao butter, chamomile oil, carrot oil, cucumber oil, beef tallow fatty acid, kukui nut oil, safflower oil, shea butter, liquid shea Fat, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, owl, coconut oil, beef tallow, lard Or hydrogenated products of these oils and fats (cured oil, etc.).
[0032]
(2) Wax
Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax, rice wax, squalene, squalane, pristane, etc.
[0033]
(3) Mineral oil
Liquid paraffin, petrolatum, paraffin, ozokelide, ceresin, microcrystalline wax, etc.
[0034]
(4) Fatty acids
Natural fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid, isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid , Synthetic fatty acids such as 2-methylpentanoic acid, 2-ethylhexanoic acid and isopentanoic acid.
[0035]
(5) Alcohols
Natural alcohols such as ethanol, isopyropanol, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol and phytosterol, and synthetic alcohols such as 2-hexyldecanol, isostearyl alcohol and 2-octyldodecanol.
[0036]
(6) Polyhydric alcohols
Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol, polypropylene glycol, 1,3-butylene glycol Glycerin, pentaerythritol, sorbitol, mannitol and the like.
[0037]
(7) Esters
Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, diethyl phthalate, phthalate Dibutyl acid, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, and the like.
[0038]
(8) Metal soap
Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate, etc.
[0039]
(9) Gums, sugars or water-soluble polymer compounds
Gum arabic, benzoin gum, danmar gum, guaiac gum, Irish moss, Karaya gum, tragacanth gum, carob gum, quinseed, agar, casein, lactose, fructose, sucrose or esters thereof, trehalose or derivatives thereof, dextrin, gelatin, pectin, starch, Carrageenan, carboxymethyl chitin or chitosan, hydroxyalkyl (C2-C4) chitin or chitosan to which alkylene (C2-C4) oxide such as ethylene oxide is added, low molecular chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorus Oxidized chitin or chitosan, alginic acid or salt thereof, hyaluronic acid or salt thereof, chondroitin sulfate or salt thereof, heparin, ethylcellulose, methylcellulose, carboxymethylcellulose, carboxy Siethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide and polypropylene oxide, or The cross-linked polymer, carboxyvinyl polymer, polyethyleneimine, etc.
[0040]
(10) Surfactant
Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate ester salt, alkyl phosphate ester salt), cationic surfactant (alkylamine salt, alkyl quaternary ammonium salt), amphoteric surfactant: carboxylic acid Type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant, nonionic surfactant (ether type nonionic surfactant) Agent, ether ester type nonionic surfactant, ester type nonionic surfactant, block polymer type nonionic surfactant, nitrogen-containing type nonionic surfactant), other surfactants (natural surfactant, protein Hydrolyzed derivatives, polymer surfactants, surfactants containing titanium and silicon, fluorocarbon surfactants Etc..
[0041]
(11) Various vitamins
Vitamin A group: retinol, retinal (vitamin A1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), Pyridoxine (vitamin B6), cyanocobalamin (vitamin B12), folic acid, nicotinic acids, pantothenic acids, biotins, choline, inositols, vitamin C group: vitamin C acid or derivatives thereof, vitamin D group: ergocalciferol (vitamin D2 ), Cholecalciferol (vitamin D3), dihydrotaxosterol, vitamin E group: vitamin E or derivatives thereof, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K2), menadione (vitamin 3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, .gamma.-oryzanol, orotic acid, vitamin P such (rutin, eriocitrin, hesperidin), vitamin U and the like.
[0042]
(12) Various amino acids
Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine And amino acid derivatives such as sulfate, phosphate, nitrate, citrate, or pyrrolidone carboxylic acid.
[0043]
(13) Various additives derived from plant or animal materials
These are processed in a conventional manner according to the product type and form to be added (for example, pulverization, milling, washing, hydrolysis, fermentation, purification, pressing, extraction, fractionation, filtration, drying, pulverization) , Granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization and the like are arbitrarily selected and combined), and may be arbitrarily selected from various materials.
[0044]
The solvent used for the extraction may be selected in consideration of the intended purpose and type of the product to be provided, or the processing performed later. Usually, water, a water-soluble organic solvent (for example, ethanol, propylene glycol) , 1,3-butylene glycol, etc.) is preferably used. However, when it is not preferable to contain an organic solvent depending on the application, it is sufficient to use only water or ethanol that can be easily removed after extraction, and it may be used alone or in any mixture with water. The thing extracted and extracted may be sufficient.
[0045]
In addition, when using additives derived from plant or animal-based ingredients for systemic or topical external preparations and cosmetics, it protects skin and hair, moisturizes, improves touch and texture, imparts flexibility, and stimulates Relaxation, stress relief by fragrance, cell activation (cell aging prevention), suppression of inflammation, improvement of skin and hair quality, prevention of rough skin and its improvement, hair growth, hair growth, hair loss prevention, imparting gloss, cleansing effect, In addition to cosmetic effects such as fatigue relief, blood flow promotion, and warm bath effects, effects such as flavoring, deodorization, thickening, antiseptic, and buffering can also be expected.
[0046]
Specific plants (herbal medicines) as raw materials include, for example, almonds (toen), ai (indigo leaves), aokazura (Keifu Fuji), Aoki (Aoki), Aogiri or Kenashia Ogiri (Ao Tung), Aotsu Samurai (wooden candy) , Acacia, red pepper (red urn), red spruce `` fruit '', red clover, red grape, red sardine (logwood), red wrinkle (red bud), red radish (red bud), red radish or red squirrel (yellow), agi (red eel), red pine , Akinire (crust), Aguay Guasu, Aguahe (Omitengu Palm), Akebi (Kitsu), Asa (Makojin), Malva morning glory or morning glory (Toshiba), Hydrangea (hydrangea), Ashitaba (Tomorrow), Azuki (Red Azuki), Acerola, Asenyaku (Asen Yaku), Athira (Shokuyo Kanna), Anise, Abiu, Abiurana, Brassica, Abemaki `` Fruit '', Avocado, Ama, A Macha (Amacha), Achacharu, Amadokoro (Bamboo bamboo), Amana (Light Jade), Amaranth (Amaranthus, Hagatetou, Higegateto, Senninkoku, Sugimorigateto, Hosooaogeito, Aogateto, Haribiyu, Amaranthus Hippocondoricus) Mother), Aristolomeria (Yurizuisen), Arcana (Arcanna), Argarovo (Cabbage), Altea, Arnica, Alpinia or Katsumadai (Suzukuku), Aloe (蘆薈), Aloe Vera, Angelica, Apricot or Honang (Anzujin), Ansokkou (benzoic incense) , Yellow sapote, Igakouzorina (Gallhead), Ikarisou or Yachima Taikoshi (Inyokaku), rushes (Ginseng grass), Itadori (Tiger root), Yew (first place), Strawberry, Fig (no fruit `` fruit, leaf ''), Ichihatsu (first), Ichibi (winter lion), Ichi Yakuso (one herb), Ginkgo (Ginkgo `` Seeds, Leaves ''), Japanese beetle (Dianthus), Carob bean, Inazuna (Tailexi), Inubiyu (Honagainubiyu), Rice `` Seeds, Seed coat '', Inondo `` Seeds '', Ibukikakuso, Nettle, Ylang Ylang, Iwa Tobacco (Iwabuchi), Iwahiba or Iwamatsu (Makimaki), Oolong Tea, Fennel (Welcome), Wheat (Chibusanoki), Ukiyagara (Three Ridges), Uguisukagura `` Fruits '', Japanese Meadow, Turmeric (Uranium), Duckweed (Float), Usubasaicin or Keirinsaishin or Oshusaishin (spicy), Usbenia Oy, Usubenitachia, Nepenthes (Summer hay), Udo or Shishiudo (Aki, Aki, Tang Dynasty), Unyadegato (Uncaria, Cats Claw) , Uba tea, Japanese apricot (Japanese apricot `` seed, pulp ''), Vulture, Japanese eel Sea urchin (Chen), Estragon, Ezoukogi (蝦 夷 五 加), Echinashi (Horaxum barrengiku), Enishida, Enokitake (榎 茸), Ebisugusa or Cassia tora (Keiko), El Campre, Elderberry `` fruit '', Elemi, Elingi or Pre Lotus Elinji, Enju (Spirit, Satsuma Rice), Ogi or Kibana Ougi (Yellow), Ousei (Naruyori, Kagikarumabanaruyori), Osasanoyuki or Sasanoyuki, Ouren (Yoren), Ogata Houken, Okarasuuri (Calcon) Ooguruma (Civil engineering incense), Otsu ヅ rafuji (preventive self), Psyllium (car forerunner, car forerunner), Toucan beetle (lion lion), Toucan cactus, Ovana okera or Okera (white moth), Ovanasasuri (Banaba), Obaya chabushi "fruit", Steller's beetle (cereals), Omia catechu, Omisanza Rabbit or hawthorn (barley), barley (barley), oca, casserole (snake bed), okra `` fruit '', oguruma (turnover), ginseng or ginseng (carrot), hypericum or ginseng or hypericum (Continued), Onamomi (Bird), Onigurumi, Onidokoro or Tokoro or Nagadokoro (Hikai), Onino Yagara (Tempa), Onyuri or Sasayuri or Hakatayuri (Yuri), Onionis, Halibut (Flyer), Ominaeshi ), Yuuko, Dutch mustard (watercress), Dutch jellies, Dutch honey bees, olives `` fruits, seeds, leaves '', oregano, orange `` fruits, peels '', silkworms (ripening yellow), cacao `` fruits, peels, seeds '', Oysters (柿蒂 葉 “leaves”), Kajikazura (Kyoto), Oyster prickly or Kantorisou (Golden grass), Gaku hydrangea, Kaki Shea, casino ki (fruit berries), gadgets (bamboo shoots), oak wrinkles (bamboo shoots, birch leaves), cascarilla, cascala grada, gypsophila, gypsophila, cynomolgus (Kin Sato), kaniwa, carnation, valerian (valerian) , Birch or weeping birch (white birch), gerbera, pumpkin, capockonoki `` seed '', Japanese cabbage shark (蜀椒), cattail (yellow), chamomile or roman chamomile, chamomile (weed), cam cam (camo duck), color, carax salmon Or Cinnamon cucumber (Wang 瓜), Crow bishak (half-summer), oats, guarana `` seed '', kalahoo (shock), karaya, galyu, karin (garden), garcinia, kawamidori, kawara psycho (commissioned vegetables, tranquilized white grass) , Kawajisha, Kawaratake, Kawaranadeshiko (stone bamboo) or Ezokawara Nadeshiko (soba, buckwheat), Kawara carrot (blue straw), Ray mugwort (canned chin), kansui (sweet candy), licorice (licorice), cantalara, candelilla, kanto, canna, raspberry (Ezo strawberry, Dutch strawberry, shrimp strawberry, nava strawberry, maple strawberry, European raspberry), kiwi `` fruit, leaf '', Kikarasuuri (Gurone), Oyster (Kikkyo, Kikyo-root), Chrysanthemum, Chrysanthemum, Ginkgo biloba, Kikutaniku, Kisage (Kashimi), Gishigishi (Yotei), Kizuta, Kitechi Aloe, Kidachihakka , Quina, linden (shinkona, red linden), quinoa (quinoa), yellowfin (yellow twilight), gymnema sylvestre, kimenkaku, cabbage, cabbage `` unripe fruit '', cucumber, gyory (Nishikawa willow, taro willow), kiraja saponaria, kiraya , Kiransaw (Kinza Kosaku), Kumquat "fruit", Ginsakai, Kimbusen Betel, goldfish, guapeba vermelha, guava `` fruit '', guayule, quercus infectria (garlic), kukui nuts, wolfberry (bamboo shoots, coconut leaves, cocoon leaves, ground bark), sedge beetle (Tenmon winter), Kudzu (Kuzunoku), camphor, gooseberry “fruit”, carrot carrot (yellow flower camellia), cutiti river, gardenia (mountain lion), squirrel (song), Kupuas, kumazasa, pine moth (clasp), Clara (bitter) , Cranberry `` fruit '', chestnut `` seed, fruit, astringent skin '', curkurigo latifolia `` fruit '', grapefruit `` fruit and leaf '', buckthorn, black moth (rescue necessity), kurobanahikokoshi or hikiokoshi (prolongation grass), cloves (clove, clove, Clove), gumbai nazuna (Sekimei, Sekimeishi), kei-gai (butterfly, 荊芥 ho), keito (chicken flower, chicken crown), get Vidin, bay (Laurel), Kenashi Sartorii rose (Dogo, mountain return), Gentiana, Gennoshouko (Oldgrass), Kemponashi (Kigushi), Kokisekoku, Kishumikan (Koji, Tachibana, Obenimikan, Fukurimikan, Sagamikouji, Pang, Kang (Tachibana bark)), Koshinbara (monthly flower), Kousuihakka, Kozo `` fruit '', Kocha (tea), Kohone (river bone), Kohon (Tsubakimoto, Karatsumoto), Koryang, Koryokyo (Korajo), Koendoro `` Fruit '', kohlen (huo ren), koganebana (yellow gon), bilberry (koshi tachibana), coco coconut `` fruit '', goshyu (goo), gosho strawberry (pepper bonsai), pepper (pepper), cosmos, copaiba balsam, coffee `` seed '' , Leaves '', kobushi or magnolia (hot pepper), burdock (beef bowl, beef eggplant), kobotan lees, sesame (sesame), sesame seeds ( Gensen), trash (Gomiko), Saneka or Binanzaka or Matsubusa, wheat (wheat), rice or rice bran `` red rice, white birch '', rice oil, cola acuminata `` seed '', cola vera `` seed '', colony llya, koroha `` Fruit '', Colombo, Conzurango, Comb, Konjac, Comfrey (Chang Zhang grass), Sisal (Sisal Asa), Saxima button eel or cinnabar eel or Chinese ginseng (wei Sensen), Sakura (Oshima cherry, Yamazakura, Oyamazakura, Edhigashira, Bean cherry , Miyazaki cherry, Yoshino cherry tree, Takane cherry, Kasumi cherry, Kohigan, Sato cherry, Kanzakura `` Leaf, flowers, fruit, bark (cherry bark) ''), cherry, pomegranate, Sasa, Sasanka, Sodamodaka, sweet potato, sugar cane, sugar beet, Sanebuto jujube (acid soy sauce), saffron (banban , West safflower), sapodilla, sapotea mariyo, pomelo `` fruit '', savonso, salmon berry `` fruit '', salamander (sage), salvia (sage), scallop (mountain), sawagurumi (mountain walnuts), sankaku cactus, sangre Degrad (croton), Cinnamon carrot, Sancini carrot (Ginseng ginseng), Sanshuyu (Yamamuro), Sansho (Yamamuro), Sandskon (Yamazune), Shia (Kalite), Cyano `` fruit '', Shiitake mushroom (Shiitake) ), Zion (Purple moth), Diquitaris, Cyclone (Princess), Perilla or Blue-tailed moth, Chile-mento or Catamendizo (Shiyo leaf, Shiso-ko), Rosewood, Shinanoki, Shiraho-noki, Shirarenyo (ream), Shimeji (Himushiji, Shakashimeji, Hatake-shimeji, Oshiroi shimeji, beech shimeji, honjimeshi, shirotamogitake) Potato, Peonies (Shakuyaku), Shajin (Shasan), Jasmine (Matsurika), Janohige (Wheat Gate Winter), Shukukonkamiso, Shukushamitsu (Sanjin, Shredded Sandals), Juzudama, Shul "fruit", Ginger (Ginger) , Zouzan hydrangea (Tsuneyama), Shobu (bamboo shoot, root), Shozuk `` fruit '', Shirakashi `` Seeds '', Shirocho butterfly `` Seeds '', White clover (Clover), White clover (chicken bone grass), Shirobanairis (Nioiris), Shirobanatsuta "Flowers", Shirominanten (Minami Tenmi), Shinkonasakushirubura, Zinchoge (Mizuka, Mirika, Shencho), Cinnamon, Cinnamomum Cassia (Kaishin), Watermelon (Saijo), Honeysuckle (Gin Silver Flower, Shinobi Winter), Sorrel ( Acid model), swim berry `` fruit '', star apple, stevia, strawberry `` fruit '', tin psycho (Xu Chang), sugina (question), sub Sweetfish (horse tooth, horse tooth soap), plums `` fruit '', Japanese red pine `` ball cone '', Japanese larch, Japanese kizuta, Japanese walnut, Japanese hawthorn, Japanese dandelion, Japanese horse chestnut (Maroni), Japanese pear `` fruit '', Sunflower, Elder, Apricot (Juniper, Juniper), Achillea millefol (milfoil), Rose, Pteropus, Mistletoe, Acacia or Acacia, Wasabi, Gecko (Sardine persimmon), Cedron (Bow squirrel), Zeniaoi, Hiroha Senega, Senega, Seri, Celery, Senkyu (river cucumber), Senshinren (Centennial ream), Sendan, Sennin cactus, Senna `` Fruit, leaf '', Sennin (Daisen), Assembly (this drug), Soviet Mosquito (grass), Elephant rape, Sobashinboba, Buckwheat `` Seeds '', Somer potato, Daio (daihuang), Daikon radish, Soybean, Daidai (orange peel, persimmon), Takasaburo (Chinese lotus), Takatodai (Oyodo), Takakawarabi (狗) Spine), dark sweet cherry `` fruit '', hollyhock, hollyhock (thyme, perilla), tachidokoro (hikai), tachiyanagi, tamarind `` seed '', onion, ramshiba (hot pepper), taranki `` fruit, leaf, root bark '', dahlia (Tenjiku button), tarwi, tanshichiwa, tanjin (dansang), dandelion (蒲 蒲 英) or shirobana dandelion or mouko dandelion, danmaru, cherry `` fruit '', chigaya `` fruit, root, bud '', chiketsujinjin (bamboo ginseng), chicory , Chanca Piedra (Kantachikankansou), Ginseng (Larby Yellow), Ginseng (蕪 夷), Datura ), Choreimaitake (猪苓), Chorogi, camellia, Tsukuritake (mushroom), camellia, camellia, camellia (lacquered grass), camellia (duck grass), tsuzukizuki (red red beans), tsurudukudami (what neck rice cake), tsuruna (蕃) Apricot), Tsuru carrot (Yotsuban), Azalea, Deco, Teuchigurumi, Duberry `` Fruit '', Tulip, Choco Stay, Tengusa, Tencha (Chinese tea), Tendai Yaku (glaze), Toga (winter eggplant), Toka Kazura, Pepper ( Panyu), Toki (Today), Tokinsenka (Marigold), Tounabena (river cut), corn or corn hair (Southern cocoon), Scotch mochi (Sadako), Torindo or Chosen gentian (dragon gall), Tokusa ( (Wood bandits), dokudami (ten medicines), tokon (roots), toshi or bean pods or pears, tochu (Tochu `` bark, leaves, roots ''), ash ( Husk), tomato, tragacanth, triacanthus `` seed '', eustoma, tormentilla, dronoki, troloaoi, nigerian berry `` fruit '', yam or yam (wild boar), nagii kada (butcher bloom), naginata koju, nazuna, rapeseed, jujube Or vertical blade (sword beans), Natsumikan, jujube (Otsuchi), Nani Waibara (Golden Cherry), Navena (continuous), Nameko, Naruko Yuri (yellow spirit), peanut (peanut), Nanten (Southern fruit), Nanban karamushi (Reed) , Japanese violet, Nigaki (bitter tree), Nigori mugwort (bitter melon), Nikuzuku, Kay or Nikkei or Ceylon Nikkei or Yab Nikkei or Keishi (Katsura branch), Japanese leek (lion), elderberry (bone, `` fruit, flower , Stems, leaves ''), garlic (large coral), nurde (penta), leeks, nemony or nebu or nebi or nemlinoki or digokubana (Community), white thistle (big eagle), nobara (fruitful), yellow rose (flower), nogateto, yarrow, nodake (apricot), nobara, peach, pineapple `` fruit '', hibiscus (bushouge, furinbusouge, roselle), hailedou , Hauchiwa, Pau Dorse, Hakamura Laboshi (bone crush), Hakusen (white crust), Hakulberry `` fruit '', Hakobe (breeding), Hazel (lion), Hashiridokoro (roth root), Basil, Lotus (lotus, lotus meat) , Renko), Parsley (Netherlands jelly), Hadakagi, Batata, Hachiku or Madake (Bamboo bamboo), Patchouli, Hakka (light load, light load leaf), Barley (Yokuinin), Hanasuge (my mother), Banana, Hanahaku, Hanabishi (Shiturishi , Shishitsuri), Vanilla Bins, Papaya, Hakogakusa (Reed Grass), Pahalobobo, Hub "Whole Grass, Stem, Leaf", Paprika, Hamago or Mitsuba Maggots (Vulgaris), Hamasuges (Katsukiko), Hamabishi (Shitsuko), Hamanasu (Maikai), Hamaboufu (Hamaboshi), Hamamelis, Palm, Roses, Balata, Balata Rubber, Agaric, Agaric ), Haran, Pariurus (Prunus japonicus), Parietalia, Balsamina (Spirea, Nigari), Harunire (Skin, Shirakaba, Kashiwa), Barbasco, Harlindo, Handaikai (Pure Sea), Panoki, Giant Seaweed ), Lizard carrots (participants), pecan nuts, ganbanana (stone crabs, vine seeds), hygurmadaria, cypress (rhizomi), pistachios, beets, scabbard, scabbard, daisies (daisy), hinata Inokozuchi (cow knee), cypress, hiba, castor, sunflower, bell pepper, Himeuzu (Tengu), Himegama (Kaori), Hihi Matsutake (Kawariharatake, Hiromatsutake), Pimenta `` fruit '', beakshi, beakkyu, Japanese apricot `` fruit '', belode oyster, hirohaokinagusa (bald bald eagle), loquat `` fruit, leaf, stem '', betel row (large clothes, coconut), Pu'er tea (Fuyu tea), Japanese quail (South wicker), Japanese cypress, Japanese dandelion (Japanese winter flower, Japanese cypress winter leaf), Japanese wisteria (Orchid), Japanese bean (Japanese peas), Japanese red bean (Chujizakura, cocoon), grape "fruit, pericarp, seed , Leaves '', beech, Fuyumushinatsu Satake (Cycium Cordyceps), Brazilian licorice, Brazilian carrot, black currant `` fruit '', blackberry, brunnen, plum `` fruit '', full ceria, blueberry, prune, floral blanka, blond psyllium, bundo (Mung Bean), Hazelnut, Loofah, Safflower (Safflower), Heneken, Belladonna, Berri `` Fruit '', Persair, Pervianburg, Pereschia grandifolia, Benxis or Ixusa (scenic sky), Boysenberry `` Fruit '', Bakigi or Siwa or Nendo or Hahagigi Kokia (skin), Hosenka (Dusen, Acute, (Peaceae), powteria sapota, powteria rukuma, spinach, bowfish (windproof), spinach, physalis (Torune), honoki (Japanese rustic, magnolia), bokeh (wooden moss), hosobaabraiku (painful), hosobaoguruma , Hosobanaokera (bamboo shoots), Hosobano Kirinso (Keiten 37), Hosobabarengiku, Bodaiju (bamboo tree), buttons (peony `` flowers, leaves, stems, bark ''), button pi (peony skin), hops, jojoba, borage ( Rurichisha), Bordeaux, Whiteberry Berry "Fruits", Hononiku (meat juju, Taigei), Honsekoku (iron skin stone, sparrow mountain stone wall), Mai Zultennan Show (Tiannan Star), Maitake (Maiko), Maou (Mahuang), Maca, Macadamia Nut, Margaret (Mokushungiku), Macri (Marine Grass), Magwa (Mulberry White Bark “Bark, Leaves”), Magnolia Sprengeri , Masalaanba, Masalanzuba de Ceara, Masheira de Boi, Mashua (Tamanusen Hallen, Kyukonkinrenka), Matatabi (Mushrooms), Matsukasa, Pine "Leaf, Bark, Root", Matta Oryo, Matsuhodo (茯苓), Matico (Cordon Sillo), Mayorum (Hanahakka), Malvano jardin (Bitter), Mulberry `` Fruit '', Quince, Malene (Birod mud squid), Mango, Mangosteen, Manzanya (Andesca mitsule), Manshu gurumi, Mandarin `` Fruit ”, Mannentake (Ganoderma lucidum), pheasant (fruit berries“ fruit ”), Mishima Psycho (Shibahu), Mizu Plantain or Japanese morning glory (Dragon grass), Mizokakushi (half-sided lotus), Misohagi (Chikuma), Michiyanagi or Niwayanagi (History), Mitsugasiwa, Mitsuba, Midorisapote, Green lily, Mimosa, Mioga, Miracle fruit "Fruit", Myrrh , Myrobalan, wheat straw, mugwort, mugwort, mugwort (prolonged skin), munya, murasaki (purple), murasakikibu or oomurasakikibu (purple pearl), murasaki corn, murasaki kinfuji (Kunming chicken blood wisteria), megakansa opuntica , Swordfish (beneficial herb), Meowugi, Melaroika, Melissa, Merirot, Melon `` Fruit '', Moukomugi, Mosouchiku, Mokukirin, Mogi (Pepper), Mokko (Mokuko), Momijidaio, Peach (Peach `` Leaf, Seeds, Flowers) , Fruit "), sprout, Morello cherry" fruit ", Moroheiya (burlap), Ya Kawamurasaki potato, yakchi (masutachi), cornflower (cornflower), cornflower mint, yacon, yashabushi (yash) or himeya shabushi or oyabaya sabushi `` fruit, pericarp, fruit ear '', yachiyanagi, scorpion (octagonal gold plate), mistletoe (willow parasitism) ), Willow (kawayanagi, tachiyanagi, weeping willow, red willow, cat willow, incolyana, kinu willow, koryanagi, unryu willow, miyagi willow, palm, yamayanagi, okibana willow, yam (Purple gold beef), Yabu tobacco (crane basket, Tenmeisei), pokeweed (commercial land), Yamahanoki (Yamabuchi), yamamomo (Yamamushi), sagebrush, eucalyptus, yukinoshita (tiger ear grass), yucca or flevifolia, yuzu `` Fruit '', lily, sagebrush, mugwort ( Leaf), Ligan (Raimaru), lime `` fruit '', rye, lacanka `` fruit '', raspberry `` leaf, fruit '', latania (chlamellia), rakkyo or shallot (palm white), lavender, longan (long-eye meat), agave (aono) Agave, fuchlin agave), ryokcha (green tea), apples `` fruit, seeds, leaves, roots '', gentian, lubas or suabisimus (cooled), litchi (toothpick, toothpick), lettuce (tissue), red currant `` fruit ”, Red Pitaya, Lemon“ Fruit ”, Lemongrass, Forsythia or Syringa (Rengoku), Forsythia, Wintersweet, Wacoal, Lokon (Yoshi, Sone), Loganberry“ Fruit ”, Rosemary (Mannenrou), Rose Hip (Novara), Wasabi, Watafujitsugi (Mitsumona), Waremokkou (earthen) and the like.
[0047]
In addition, other seawaters such as sea salt, dried sea water, dead sea or Atlantic or Pacific sea water (sodium chloride, magnesium chloride, potassium chloride, etc.), sea mud or mud (fango), such as Sea mud or mud from various locations such as Italy, Fango, German Fango, Eifel Fango, Freiburg Fango, etc. (Ingredients: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide Strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), saintoku stone, etc.
[0048]
As seaweeds, seaweed [Green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, Aonori (Usba aonori, Sugiaonori, Hiraaoori, Boaonori, Hosoeda Aonori), Anaaoosa (Aosa)] (Macombu, Resilibu, Hosocome, Mitsuishi Kombu), Wakame, Hirome, Aowakame, Giant Kelp (Macrocystis Integrifolia, Neocitus Ruetkeana), Hijiki, Hibamata, Umiuchiwa, Usubaumiuchiwa Umiuchiwa, Akaba Umiuchiwa, Konami Uchiwa, Okinawa Uchiwa, Usuki Uchiwa, Etsumi Uchiwa], seaweed [Red algae: Hijirimen, Maca (Tengusa), Hiraksa, Syria, Oaxa Caterpillar, Yatabegusa, Yuukiri, Shimatengusa, Tosakanori, Togekirinsai, Amakusakirinsai, Giraffe, Juniper ginkgo rhinoceros, Tsunomata, Totsuka (Yahazutsu notamata), Ezotsunotamata, Togetu no Takita , Yaleus banori, Kagius banori, Susius banori, Haius banori, Akamo mizunori] and the like.
[0049]
In addition, other algae such as green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Anemone: Quanomomo, Volbox: Ougenmawari, Volbox, Palmera, Yotsumeo, Aomido: Chrysanthemum, Aoumidro, Tirguimidro, Hibidoro: Hibidoro, Aosa: Anaaaosa, Amiaosa, Nagaaosa, Kawanori: Kawanori, Friccella, Shiogusa Magama genus: Magamata, Iwagata: Fusaikawa, Surichogata, Heraiwata, Kurokita, Hanemo, Genus: Mill, Chromel, Sakibutimil, Nagamil, Hira Lemon, Casanori genus: Casanori, Jusmo genus: Jujusmo, Tamajusmo, Mizojuzumo, Mika ヅ kimo, Korekaete, Tsutsumimo genus: Kyukougusa, Hitogususa genus: Humanegusa, Hirohatohigususa, Umushihimoe, Sakikimoe Sumiremo: Sumiremo, Hoshimamidro, Fushinashimidoro etc.).
[0050]
Cyanobacteria (Suizenjinori: Suizinori, Aoko, Nenju: Kawatake, Ishijelly, Hassai, Yuremo, Rasenmo (Spirulina): Spirulina, Trichodesmium (Iaciasio), etc.
[0051]
Brown alga Sanadagusa: Sanadagusa, Fukurimamiji, Commongusa: Commongusa, Yahazugusa: Ezoyahaz, Yahazugusa, Uraboshiyahaz, Jigamusa: Jigmygusa, Umichiwagusa, Umamisakugakua, Hakusou : Navarimo, Chasomen genus: Motsuki Chasomen, Matsumo genus: Matsumo, Nagamatsumo genus: Nagamatsumo, Okinawa mozuku: Okinawa mozuku, fake Tomozuku: Niseft Mozuku, Futomozuku: Futomozuku, Ishimozuku: Ishimozuku, Kuromo: Kuromo, Nisemozuku: Nisemozuku, Mozuku: Mozuku, Ishige: Ishige, Iroro, Ichimegasa: Ichimegasa Umibosu, Urushigusu: Urushigusa, Keurushigusa, Tobaccogusa, Composita: Composita, Haberodomo: Haberodoki, Havanori: Habanori, Habanori: Habanori, Commonbukuro, Ezobukuro, Ezobukuro Chishima fukuronori genus: Chishima fukuronori, Kagomenori genus: Kagomenori, Muraridori genus: Murachidori, shark genus: shark zusa, genus genus: lobster, genus genus: yokojimamanori, Ganoderma genus: cynomolgus, fennel spider: fennel spider, vine genus: turmo, turtle genus: sea turtle, scorpion genus: sujime, misji kumbu genus: misji kumbu, atsuba misji kumbu, kumbu genus: tsutsugara kumbu, oyster kumbu, onikombu, gakonbubu Barracuda, Trollocombu: Trollocombu, Antokume: Antokume, Kajime: Kajime, Tsuruarame, Kurome, Kikuishikombu: Kikuishicombu, Nejikcombu: Nejicombu, Kuroshiome: Kuroshiome, Nekoshikonbu, Aramei Genus: Ainuwakame, Chigaiso, Oniwakame Ezoi Shige: Ezoi Shige, Yabane Moku: Yabane Moku, Rappa Moku: Rappa Moku, Joromoku: Ugano Moku, Jo Lomoku, Hiemoku, Honda Walla: Tamanashimoku, Isomoku, Nagashimamoku, Akamoku, Shidamoku, Honda Walla, Nejimoku, Narasamo, Mametawala, Tatsukuri, Yatsumata Moku, Umitora no Moku, Fushishimoku, Mohmokumoku, Hahamokumoku , Ukimo: Ouokimo, Burukimo: Burukimo, Kayamonori: Kayamonori, etc.).
[0052]
Red algae Genus: Sea urchins, Tsukumonori, Anemone crickets, Astragalus, Amaranthus, Amaranthus, Agaricata Genus: Tamaitadaki, Kaikekenori Genus: Kaginori, Kaikekenori, Tengusa: Himetengususa, Hytengususa, Oobusa, Nambugu , Kohira, Yohira, Kinukusa, Hibirodo: Hibirodo, Himebiro, Isomumedo: Isommedo, Aedes: Rhizome, Ryumons: Ryumon, Ranunculaceae, Nisekare Naminohana: Hosobanaminohana, Naminohana, Sangomodoki: Ragaramomodoki, Shiogusagoromo: Shiogusagoromo, Iwanokawa: Etsukiiwanawa, Kinokawa: Kinokawa, Kanonote, Sangori Kyono Shiro, Sakuranori, Nikumukade, Tambanori, Tsurutsuru, Fudarak, Marubahdarak, Isonohana: Nurakusa, Ronulaksa, Oomkadenori, Hirakintoki: Hirakintoki, Matabou: Matabou, Kintoki: Chabokintoki, Kintoki, Matsunori, Rice, Tokamatsu, Hitomatsu, Fushikintoki, Tsunomude, Nagakinito, Crayfish Nagaobane: Naganobane, Funori genus: Hanafonori, Fukurofunori, Mafunori, Karekigusa: Karekigusa, Tosakamodoki: Hosobanatosakamodoki, Hironotosakamodoki, Yatsudegatatosakamodoki, Kurotosakamodokisane, Zotosofomoza Tosakamodoki, Nankaitosakamodoki, Himetosakamodoki, Kinuhada: Kinuhada, Ezotosaka: Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hana Tacarimenia, Hoonoo: Honoo, Hikagenoit: Hikagenoit, Usuginu, Nikuhounoo: Nikuhounoo, Venus nago, Venus nago, Susca veni: Suscabeni, Okarugusa: Yamadagusa, Mirin: Mirin, Hosokamiso , Isomocca genus: Isomocca, Yukari genus: Yukari, Hosoyukari, Ibaranori genus: Ibaranori, Saidaibara, Tachiibara, Kagibaranori, Kojinoo: Kizino-o, Isodantsu: Isodantsu, Atsubanori: Atsubanori, Ogonori, Ogonori, Ogori Mizo-okonori, birch, beniogonori, fukureshinori, purple birch, shinkaibanori, spruce birch, kataogonori, ryukyuogono Li, Atlantic scorpion, Ivy genus, Yumigataonori, Kubireogonori, Mosagogonori, Kinubanori, Amanita genus: Hachijotensamodoki, Fushikenori genus: Fushikenori, Namiiwatake, Nymphalanthus Itagususa, Saimi, Hari, Lotus Jigusa: Lotus Jigusa, Sugi nori: Ikanoashi, Hosoibonori, Nobonori, Black Haginansou Genus: gourd, cherries, octopus: octopus, sedge, genus: genus, genus: goat, dals : Dulse, Scorpionus, Anadalus, Weibusa: Uebusca, Benifronori: Benifuronori, Fusunagi: Futsutsunagi, Himefusunagi, Hirohafushitsugi, Otsunagisou, Hirawatagigi, Usuwasugi , Egonori: Egonori, Futogigi, Saeda: Saeda, Chirimomiji: Chirimomiji, Konohori family: Habutaenori, Konohori, Suzuronori, Usubeni: Genus: Kagios banori, Yareus banori, Susius banori, Heius banori, Usubanorimodoki: Usubanorimodoki, Ayanishiki genus: Ayani Genus: Aeginu, Dadia: Enasidadia, Shimadadia: Isohagi, Shimadadia, Dajimodoki: Dajimodoki, Euglena: Morayogusa, Fuyugusa, Makuri: Makri, Yanaginogi, Yuna, Yukinagina , Sasabayanaginori, Sozo genus: Kurosozo, Kobsozo, Hanesozo, Sozonohana, Hanegusa genus: Hananegusa, Hananegusa, Kozanemo genus: Kozanemo, Isomurasaki, Hosozozanemo, Himegoshigusu, Giant genus Isomagusa, Suginasugusa: Suginasusa, Isobashou: Isobasho, Fujimatsumo: Fujimatsumo, Sawweed: Haeshinosakiba, Kawamoku : Kawamoku, Aokawa Mozuku, Himekawa Mozuku, Ideyugogome: Ideyugogome, Okichimozuku: Okimozu, Otosa, Chinomo: Chinomo, Chisujinori, Chisujinori, etc.).
[0053]
Axial algae (Shajikumo, Shiratamamo, Hoshitsurimo: Hoshitsurimo, Rikunotumusu, Flaskmo: Himebumo, Chaboflasmo, Tripera, etc.), yellow algae (Hikarimo: Hikarimo, etc.), etc.
[0054]
In addition, the raw materials derived from animal sources include chicken crown extract, cow or human placenta extract, pig or cow stomach, duodenum or intestinal extract or degradation product thereof, pig or cow spleen extract or its Degradation products, extracts of porcine or bovine brain tissue, water-soluble collagen, collagen derivatives such as acylated collagen, collagen hydrolysates, elastin, elastin hydrolysates, water-soluble elastin derivatives, keratin and their degradation products or their Derivatives, silk proteins and degradation products thereof or derivatives thereof, porcine or bovine blood cell protein degradation products (globin peptides), porcine or bovine hemoglobin degradation products (hemin, hematin, heme, protoheme, heme iron, etc.), milk, casein and Decomposition product thereof or derivatives thereof, skim milk powder and decomposition product thereof or derivatives thereof, lactoferrin or decomposition product thereof, egg component Fish hydrolyzate, nucleic acid-related substance (ribonucleic acid, deoxyribonucleic acid), or the like.
[0055]
(14) Microbial culture metabolites
Yeast metabolite, yeast extract, natto metabolite, natto extract, rice fermented extract, rice bran (red koji, birch) fermented extract, euglena extract, lactic acid fermented milk or trehalose or its derivatives, etc. .
[0056]
(15) α-hydroxy acids
Glycolic acid, citric acid, malic acid, tartaric acid, lactic acid, etc.
[0057]
(16) Inorganic pigment
Silica, magnesium silicate, talc, kaolin, bentonite, mica, mica titanium, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide , Gunjo, chromium oxide, chromium hydroxide, carbon black, calamine, etc.
[0058]
(17) UV absorber / blocker
Benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone-sulfone Acid sodium, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), p-aminobenzoic acid derivatives (paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate) ), Methoxycinnamate derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, paramethoxycinnamon Acid sodium, potassium paramethoxycinnamate, glyceryl di-2-methoxycinnamate mono-2-ethylhexanoate, etc.), salicylic acid derivatives (octyl salicylate, salicylphenyl, homomenthyl salicylate, dipropylene glycol salicylate, ethylene glycol salicylate, myristyl salicylate, methyl salicylate, etc.) , Anthranilic acid derivatives (such as methyl anthranilate), urocanic acid derivatives (such as urocanic acid, ethyl urocanate), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, Furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, vitamin B6 derivatives, umbelliferone, e Clean, benzyl cinnamate, cinoxate, oxybenzone, dioxybenzone, Okutabenzon, sulisobenzone, benzo resorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, Neo Heliopan, ESCA rolls, zinc oxide, talc, kaolin.
[0059]
(18) Whitening agent
p-aminobenzoic acid derivatives, salicylic acid derivatives, anthranilic acid derivatives, coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, Allantoin derivatives, nicotinic acid derivatives, vitamin C or derivatives thereof (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or derivatives thereof, kojic acid or derivatives thereof, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin , Baicalein, berberine, placenta extract, ellagic acid, lucinol, etc.
[0060]
(19) Tyrosinase activity inhibitor
Vitamin C or a derivative thereof (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), hydroquinone or a derivative thereof (hydroquinone benzyl ether, etc.), kojic acid or a derivative thereof, vitamin E or a derivative thereof, N-acetyltyrosine or a derivative thereof , Glutathione, hydrogen peroxide, zinc peroxide, placenta extract, ellagic acid, arbutin, lucinol, silk extract, plant extract (camomile, mulberry, touki, firewood, clara, mugwort, honeysuckle, yellowfin, dokudami, matsuhod, pearl barley, Odoricho, Hop, Hawthorn, Eucalyptus, Achillea millefolium, Altea, Keihi, Mankeishi, Hamamelis, Yamaguchi, Life-grass, Kikyo, Toshishi, Zetsuko, Ishiboshi, Mao, Senkyu, Dokatsu, Psycho, Bowfish, Hamaboufu Scutellaria, peony bark, peony, cranesbill, kudzu root, licorice, Fushi aloe, Cimicifuga, safflower, green tea, black tea, Ali elixir), and the like.
[0061]
(20) Melanin pigment reduction / degradation substance
Phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide, zinc peroxide, hydroquinone or its derivatives (hydroquinone benzyl ether).
[0062]
(21) Turnover promotion / cell activator
Hydroquinone, Lactic acid bacteria extract, Placenta extract, Ganoderma extract, Vitamin A, Vitamin E, Allantoin, Spleen extract, Thymus extract, Yeast extract, Fermented milk extract, Plant extract (Aloe, Ogon, Horsetail, Gentian, Burdock, Shikon, Carrot, (Hamelis, Hop, Yokuinin, Odori Sou, Assembly, Toki, Tokinsenka, Achacha, Hypericum, Cucumber, Ginger, Rosemary, Parsley).
[0063]
(22) Astringent
Succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannic acid (including catechin compounds), etc.
[0064]
(23) Active oxygen scavenger
SOD, catalase, glutathione peroxidase and the like.
[0065]
(24) Antioxidants
Vitamin C or a salt thereof, stearic acid ester, vitamin E or a derivative thereof, nordihydrogua ceretenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, propyl gallate, sesamol , Sesamorin, gossypol, propolis, etc.
[0066]
(25) Lipid peroxide production inhibitor
β-carotene, plant extract (sesame culture cells, amacha, hypericum, clams, clove, melissa, enamel, birch, salvia, rosemary, southern fruit, ages, ginkgo, green tea).
[0067]
(26) Anti-inflammatory agent
Ictamol, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor, dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid or its salt, glycyrrhetinic acid or its Salt, licorice extract, sicon extract, age extract, propolis, etc.
[0068]
(27) Antibacterial / disinfectant / disinfectant
Acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or its hydrolyzate, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, chloramine T, salicy powder, iodine compound, iodoform, sorbin Acid or salt thereof, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m-xylenol, p-chloro -m-cresol, thymol, phenethyl alcohol, o-phenylphenol, Irgasan CH3565, halocarban, hexachlorophene, chlorohexidine, ethanol, methanol, isopropyl alcohol , Benzyl alcohol, ethylene glycol, propylene glycol, phenoxyethanol, chlorobutanol, isopropylmethylphenol, nonionic surfactant (polyoxyethylene lauryl ether, polyoxyethylene nonyl phenyl ether, polyoxyethylene octyl phenyl ether, etc.), amphoteric surfactant Agents, anionic surfactants (sodium lauryl sulfate, potassium lauroyl sarcosine, etc.), cationic surfactants (cetyltrimethylammonium bromide, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride), formaldehyde, hexamine, brilliant green, malachite green, Crystal Violet, Jamal, Photosensitive Element 101, Photosensitive Element 201, Photosensitive Element 401, N-Long Chain Acyl Base Amino acid derivatives and their acid shark salts, zinc oxide, hinokitiol, Sophora root, propolis, and the like.
[0069]
(28) Moisturizer
Glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid or its salt, polyethylene glycol, chondroitin sulfate or its salt, water-soluble chitin or chitosan derivative, pyrrolidone carboxylic acid or its salt, sodium lactate, mini sasanishiki extract, natto Metabolites, natto extract, loofah water, birch (white birch) or red pine sap
[0070]
(29) Elastase activity inhibitor
Fluorophosphate diisopropyl, plant extract (Ogon, Hypericum, Clara, Mulberry leaves, Keihi, Gennosho, Comfrey, Salvia, Elderberry, Bodaige, Buttonpi), seaweed extract, etc.
[0071]
(30) Hair preparation
Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castari tincture, pepper tincture, red pepper tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, sodium bromate, thioglycolic acid and the like.
[0072]
(31) Antiandrogen
Follicular hormone (estrone, estradiol, ethinyl estradiol, etc.), isoflavone, oxendron, etc.
[0073]
(32) Peripheral blood flow promoter
Vitamin E or its derivatives, assembly extract, garlic extract, carrot extract, aloe extract, gentian extract, toki extract, cephalanthin, carpronium chloride, minoxidil and the like.
[0074]
(33) Stimulant
Pepper tincture, nonyl acid vanillamide, cantalis tincture, ginger tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate, etc.
[0075]
(34) Metabolic active agent
Photosensitizer 301, hinokitiol, pantothenic acid or derivatives thereof, allantoin, placenta extract, biotin, pentadecanoic acid glyceride and the like.
[0076]
(35) Antiseborrheic agent
Pyridoxine or its derivatives, sulfur, vitamin B6 and the like.
[0077]
(36) Keratolytic agent
Resorcin, salicylic acid, lactic acid and the like.
[0078]
(37) Oxidizing agent
Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, sodium pyrophosphate, sodium orthophosphate Sodium silicate hydrogen peroxide adduct, sodium sulfate sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract, etc.
[0079]
(38) Hair remover
Inorganic reducing agents such as strontium sulfate, sodium sulfide, barium sulfide, calcium sulfide, thioglycolic acid or its salts (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) etc.
[0080]
(39) Hair swelling agent
Ethanolamine, urea, guanidine, etc.
[0081]
(40) Dye agent
5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, orthoaminophenol, N-phenyl acetate Paraphenylenediamine, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-diamine, nitroparaphenylenediamine, paraaminophenol, para Nitroorthophenylenediamine, paraphenylenediamine, paramethylamino Phenol, picramic acid, sodium picramate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N -Phenylparaphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diamino sulfate Diphenylamine, 2,4-diaminophenol sulfate, toluene-2,5-diamine sulfate, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, parasulfate sulfate Methylaminophenol, metaaminosulfate Diol, metaphenylenediamine sulfate, catechol, diphenylamine, α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzene-5'-sulfone Sodium acid, hematein, etc.
[0082]
(41) Fragrance
Natural animal fragrances such as musk, civet, castrium, ambergris, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, guayakwood essential oil, cumin essential oil, black letter Essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriander essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, gingergrass essential oil, cedar essential oil, spearmint essential oil, western peppermint essential oil, dairy perfume essential oil, Tuberose essential oil, clove essential oil, orange flower essential oil, winter green essential oil, troubalsum essential oil, buttery essential oil, rose essential oil, palmarosa essential oil, cocoon essential oil, hiba essential oil, sandalwood essential oil, petit gren essential oil, bay essential oil, vetiva essential oil, bergamot essential oil, pel Vegetable flavors such as balsam essential oil, boad rose essential oil, melamine essential oil, mandarin essential oil, eucalyptus essential oil, lime essential oil, lavender essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary essential oil, Japanese mint essential oil .
[0083]
(42) Dyes / colorants
Red cabbage dye, red rice dye, red dye, anato dye, scum dye, turmeric dye, enju dye, krill dye, amber dye, caramel, gold, silver, gardenia dye, corn dye, onion dye, tamarind dye, spirulina dye, Buckwheat whole pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin etc.
[0084]
Others, moisturizers, hormones, sequestering agents, pH adjusters, chelating agents, antiseptic and antibacterial agents, cooling agents, stabilizers, emulsifiers, animal and vegetable proteins and their degradation products, animals and plants Saccharides and their degradation products, animal and plant glycoproteins and their degradation products, blood flow promoters, anti-inflammatory agents, antiallergic agents, cell activators, keratolytic agents, wound treatment agents, foam enhancers, thickeners, oral cavity Additives, deodorants / deodorants, bitters, seasonings, enzymes and the like can be raised, and in combination with these, various additive and synergistic effects can be expected.
[0085]
Further, the dosage form of the melanin production inhibitor, active oxygen scavenger, lipid peroxide production inhibitor, lipase activity inhibitor, antiallergic agent, histamine release inhibitor or cosmetic composition of the present invention is arbitrary, capsule, It can be blended and used in the form of powder, granule, solid, liquid, gel, foam, emulsion, cream, ointment, sheet and the like.
[0086]
Specifically, for example, external pharmaceutical preparations, lotions, emulsions, creams, ointments, lotions, oils, packs, and other basic cosmetics, facial cleansers and skin cleansers, hair removers, hair removers, after shave lotions, preshaves Makeup cosmetics such as lotion, shaving cream, foundation, lipstick, blusher, eye shadow, eyeliner, mascara, perfume, nail polish, nail enamel, nail enamel remover, shampoo, rinse, hair treatment, pre Hair treatments, hair conditioners, permanents, hair nicks, hair dyes, hair cosmetics such as hair growth and hair nourishing agents, bath preparations, deodorants, deodorants, poultices, plasters, tapes, sheets, patches, Suitable for various products such as aerosols, toothpastes, mouth fresheners and gargles, sanitary cotton, wet tissue, etc. It can, also, can also be used to common foods and drinks.
[0087]
In addition, about the method of addition to the cosmetic composition of this invention, it may add beforehand, may add in the middle of manufacture, and should just select it suitably in view of workability | operativity.
[0088]
The melanin production inhibitor, active oxygen scavenger, lipid peroxide production inhibitor, lipase activity inhibitor, antiallergic agent, histamine release inhibitor or cosmetic composition of the present invention is added in advance. However, it may be added during the production, and may be appropriately selected in consideration of workability.
[0089]
【Example】
Hereinafter, production examples, test examples, and formulation examples will be described. However, the present invention is not limited to these examples.
[0090]
(Production Example 1)
100 g of dried Japanese cypress is heated and extracted with purified water (about 80 ° C.) for about 5 hours and filtered to obtain about 1.0 kg of an extract (dry solid content: about 0.3 to 2.5%).
[0091]
(Production Example 2)
100 g of dried cypress is immersed in a 30% ethanol solution, extracted at room temperature for 5 days and nights, and then filtered to obtain about 1.0 kg of an extract (dry solid content: about 0.3 to 2.5%).
[0092]
(Production Example 3)
100 g of dried Japanese cypress is immersed in 70% ethanol solution, 30% 1,3-butylene glycol solution, 60% propylene glycol solution, or purified water (about 30 ° C), extracted at room temperature for 5 days and nights, and then filtered. Thus, about 1.0 kg of an extract (dry solid content: about 0.3 to 3.0%) is obtained.
[0093]
(Test 1) Melanin production inhibition test
The inhibitory effect on melanogenesis was evaluated based on B16 melanoma cells.
[0094]
"Test method and evaluation method"
The B16 melanoma cells pre-cultured for 24 hours are transferred to a fresh medium, and 0.5% of the sample is added thereto and cultured for 3 days. Next, the cultured cells are treated with trypsin, heated and dissolved in 1N-NaOH, 10% DMSO solution, and the absorbance at 420 nm is measured. In addition, distilled water was used as a blank instead of the sample, and the activity of the cells to which the sample was added at the same time was measured by the MTT reduction method (Tim Mosmann; Journal of Immunological Methods P55-63 (1983)). The MTT reduction activity of the sample-loaded cells was calculated with the MTT reduction activity of the cells as 1 unit. The amount of melanin in the sample was calculated as absorbance / MTT reducing activity (1 unit), and the inhibition rate (%) with respect to the amount of melanin produced by blank cells was determined by Equation 1, and the results are shown in FIG.
"sample"
In addition, the sample of the melanin production | generation suppression test used for the test, using the extract (solid content concentration: adjusted to 0.5%) obtained by manufacture example 2 of this invention. As a comparative sample, arbutin (manufactured by Sigma) was prepared under the same conditions and used for the test.
[0095]
<Equation 1>
Melanin production inhibition rate (%) = {1- (sample melanin amount / blank melanin amount)} × 100
[0096]
(Test results)
As shown in FIG. 1, it was confirmed that the cypress extract of the present invention significantly suppresses the production of melanin pigment and has a high melanin production inhibitory effect. Also, compared with arbutin, it can be confirmed that it has a slightly strong melanin production inhibitory action,
Can be used as
[0097]
(Test 2) Active oxygen elimination (SOD-like activity) test
In recent years, many diseases and illnesses induced by active oxygen have been reported, and it has been pointed out that removal and elimination of active oxygen (SOD activity) leads to prevention of tissue damage. In this test, the extract obtained in Production Example 2 has an ability to eliminate active oxygen generated by the xanthine-xanthine oxidase system by the present nitro blue tetrazolium method (lipid peroxide experimental method, P144, medical and dental drug publishing). ).
[0098]
"Test method and evaluation method"
To 2.5 mL of 0.05 M sodium carbonate buffer (pH 10.2) containing 1.0 mM xanthine and 3.0 mM ethylenediaminetetraacetic acid, add 0.75 mM nitrobull-tetrazolium, 0.15 W / V% bovine serum albumin, and 0.1 mL each of the sample solution. Add mL and leave at 25 ° C for 10 minutes. Thereto was added 0.1 mL of an aqueous xanthine oxidase solution adjusted in advance so that the absorbance change was about 0.3 / 20 minutes, and the mixture was allowed to stand at 25 ° C. for 20 minutes. Then, the reaction was stopped with a 6 mM CuCl solution, and the absorbance at 560 nm was measured. In addition, the control rate was obtained by adding the solvent of the sample solution instead of the sample, and further, for each sample and control, a group containing the reaction stop solution before adding xanthine oxidase was used as a blank, and the inhibition rate was calculated from the formula 2. Is shown in FIG. Further, the active oxygen capacity was calculated with the 50% inhibition rate as SOD1 unit.
"sample"
In addition, the sample for the active oxygen elimination (SOD-like activity) test was subjected to the test using the extract obtained in Production Example 2 of the present invention (solid content concentration: adjusted to 0.02%). In addition, as a comparative sample, a green tea extract (manufactured by Ichimaru Falcos) was prepared under the same conditions and used for the test.
[0099]
<Equation 2>
Active oxygen elimination rate (%) = {1− (sample O.D. value−sample blank O.D. value) / (control O.D. value−control blank O.D. value)} × 100
[0100]
(Test results)
As shown in FIG. 2, it was confirmed that the cypress extract of the present invention significantly suppressed the generation of active oxygen and had an active oxygen scavenging action. Moreover, it can confirm that it has a strong active oxygen scavenging effect compared with a green tea extract, Therefore, it can be used as an active oxygen scavenger.
[0101]
(Test 3) Lipid peroxide production inhibition test
The lipid peroxide is a compound in which an unsaturated fatty acid, which is a constituent of lipid, is added with a peroxide, mainly hydroperoxide. These lipid peroxides cause damage to cell membranes in vivo, cause inactivation of various enzymes, denaturation of biological proteins, etc., and adversely affect biological tissues. As a result, aging is promoted, and it is thought to lead to diseases such as cancerous changes. In the skin, accumulation of lipid peroxides caused by peroxidation of sebum changes the function of skin cell membranes and mitochondria. Liver spots, melanosis, primary irritation dermatitis, atopic dermatitis Or, it is said to be a cause of various skin diseases such as skin aging (wrinkles, senile pigmentation, etc.) and rough skin, and suppression of lipid peroxidation is regarded as important in dermatology. . In this test, with respect to the extract obtained in Production Example 1, the inhibitory effect on peroxidation of skin surface lipids and squalene by the iron-ascorbic acid system was measured by the TBA method (Analytical, Biochemistry. Vol.95, P351-358). (1979)).
[0102]
"Test method and evaluation method"
Take 4.9 mL of 0.8% sodium lauryl sulfate solution dissolving 0.1% linolenic acid in a 9 mL screw bottle, add 0.1 mL of the sample solution to this, and irradiate with UV light for 1 hour (using Toshiba FL-20SE and FL-20SBL lamps). After irradiating 3 lamps in parallel at a distance of 15 cm, take 1.0 mL of this solution into a centrifuge tube containing 0.02 mL of 4.5% dibutylhydroxytoluene, and add 1 mL of 0.67% thiobarbituric acid / 15% acetic acid aqueous solution. Heat at 95 ° C for 1 hour. After cooling, 4 mL of a 15% methanol-containing n-butanol solution was added, shaken well, and then centrifuged (2000 rpm for 10 minutes). The absorbance at 532 nm of this n-butanol layer was measured to obtain the amount of lipid peroxide. Similarly, the absorbance of those not irradiated with ultraviolet rays was measured, and the difference from the one irradiated with ultraviolet rays was defined as the amount of lipid peroxide produced. The inhibition rate was calculated from the ratio of the amount of lipid peroxide produced when only the solvent was added instead of the sample to 100 and the amount of lipid peroxide produced when the sample was added. The results are shown in FIG.
"sample"
In addition, the sample of the lipid peroxide production inhibition test was subjected to the test using the extract (solid content concentration: adjusted to 0.5%) obtained in Production Example 2 of the present invention. As a comparative sample, an aqueous dl-α-tocopherol solution (manufactured by Kishida Chemical Co., Ltd.) was prepared under the same conditions and used for the test.
[0103]
(Test results)
As shown in FIG. 3, it was confirmed that the cypress extract of the present invention has almost the same lipid peroxide production inhibitory action as that of the aqueous dl-α-tocopherol solution. Therefore, the cypress extract of the present invention can be used as an antioxidant.
[0104]
(Test 4) Lipase activity inhibition test
The lipase activity inhibitory action was evaluated based on the lipase activity value using the quantitative reaction of lipase in human blood as an index.
[0105]
"Test method and evaluation method"
a. Skin extract
10 g of physiological saline was added to 1 g of guinea pig dorsal skin, extracted with ultrasound, and the supernatant obtained by centrifugation (12,000 rpm, 15 minutes) was used as the skin extract.
b. Enzyme lipase
The enzyme lipase (derived from porcine pancreas / Sigma) was adjusted to 0.2 units.
c. Measurement of lipase activity
A test was performed according to the test method of Lipase Kit S (manufactured by Dainippon Pharmaceutical Co., Ltd.) using a mixed solution of 30% sample, 20% skin extract and 50% 0.2units lipase as a specimen. As a control, the solvent of the sample was used, the sample and the control were measured, and the lipase activity inhibition rate (= lipase activity inhibition action) was determined by Equation 3, and the results are shown in FIG.
"sample"
In addition, the sample of the lipase activity suppression test was used for the test using the extract (solid content concentration: adjusted to 0.3%) obtained in Production Example 2 of the present invention.
[0106]
<Equation 3>
Lipase activity inhibition rate (%) = {1− (sample BALB unit / control BALB unit)} × 100
[0107]
(Test results)
As shown in FIG. 4, the cypress extract of the present invention can be confirmed to have a function of significantly suppressing the activity of lipase, and can be used as a lipase activity inhibitor.
[0108]
(Test 5) Histamine release inhibition test
In an immediate allergic reaction, chemical mediators such as histamine are released from mast cells or basophils sensitized in the second stage. Therefore, a substance that suppresses histamine release can be expected to have an antiallergic action. This test uses a test method (J. Soc. Cosmet. Japan, Vol. 25, No. 4, P246 (1992)) that releases histamine from rat mast cells using compound 48/80, a histamine release reagent. The extract obtained in 2 was examined.
[0109]
"Test method and evaluation method"
To 1.2 mL of mast cell suspension collected from the abdominal cavity of rats (Slc: Wister male rats, approximately 4-9 weeks old), add 0.2 mL of sample and compound48 / 80 to a final concentration of 1.0 μg / mL, Incubated for 15 minutes at 37 ° C. After stopping the reaction by cooling with ice, the reaction mixture is centrifuged, and histamine released from the supernatant is extracted and purified. , The histamine release inhibition rate was calculated from Equation 4, and the results are shown in FIG.
"sample"
In addition, the sample of the histamine release inhibition test was subjected to the test using the extract obtained in Production Example 2 of the present invention (solid content concentration: adjusted to 0.05%). As a comparative sample, cromolyn (manufactured by Sigma) was prepared under the same conditions and used for the test.
[0110]
<Equation 4>
Histamine release inhibition rate (%) = {1− (AC) / (BC)} × 100
A: When a sample is coexisted with mast cells and a histamine releaser is added
Fluorescence intensity of liberated histamine
B: Released when a histamine releasing agent was added to mast cells
Fluorescence intensity of histamine
C: Fluorescence intensity of histamine naturally released from mast cells
(A, B, and C are the measured values minus the blind values)
[0111]
(Test results)
As shown in FIG. 5, it was confirmed that the cypress extract of the present invention has an action of significantly suppressing histamine release. In addition, compared with cromolyn, it can be confirmed that it has a very strong histamine release inhibitory action and can be used as an antiallergic agent.
[0112]
(Test 6) Safety test
(1) Skin primary irritation test
Japanese white rabbits (manufactured, 1 group, 3 animals, body weight) prepared with purified water so that the dry solid content concentration was 0.5% and shaved back. (Approx. 2.3 kg) applied to the skin. 24, 48, and 72 hours after application, evaluation was performed using erythema and edema as an index based on the criteria for Draise. As a result, in all animals, no erythema and edema were observed, and it was judged that there was no problem with primary skin irritation.
[0113]
(Test 7) Safety test
(2) Cumulative skin irritation test
Similarly, Hartley guinea pigs (female, 3 per group, shaved back) were prepared with purified water so that the dry solids concentration obtained in Production Examples 1 to 3 was 0.5% in dry solid content concentration. 0.5 mL / animal was applied once a day, 5 times a week to skin having a body weight of about 320 g. Application was performed over 2 weeks and shaving was performed on the last application day of each week. Evaluation was performed using erythema and edema as indices based on the criteria for Draise on the day after each application and the day after the last application. As a result, in all animals, no erythema and edema were observed for 2 weeks, and it was judged that there was no problem with respect to cumulative skin irritation.
[0114]
(Test 8) Safety test
(3) Acute toxicity test
Similarly, a ddy mouse (male and male) fasted for 4 hours before testing the powder (dry solid concentration: 1.0%) obtained by concentrating and drying the cypress extract obtained in Production Examples 1 to 3 under reduced pressure. (Female, 5 mice per group, 5 weeks old) was orally administered at a dose of 2,000 mg / kg, and the onset and degree of toxic symptoms were observed over time. As a result, no abnormalities were observed in all mice for 14 days, and no abnormalities were found in the anatomical results. Therefore, LD50 was 2,000 mg / kg or more, and was judged to be a safe substance.
[0115]
(Formulation example) Manufacture of melanin production inhibitor, active oxygen scavenger, lipid peroxide production inhibitor, lipase activity inhibitor, antiallergic agent, histamine release inhibitor or cosmetic composition
According to said evaluation result, the example of a prescription is shown below, but each prescription example may be manufactured by the conventional method in manufacture of each product, and showed only the compounding quantity. The present invention is not limited to these.
[0116]

[0117]

[0118]

[0119]

[0120]

[0121]

[0122]

[0123]

[0124]

[0125]

[0126]

[0127]

[0128]

[0129]

[0130]

[0131]

[0132]

[0133]

[0134]

[0135]

[0136]

[0137]

[0138]

[0139]

[0140]

[0141]

[0142]

[0143]

[0144]
(Prescription Example 29) Coating protective agent
A gauze or liniment cloth is impregnated with an appropriate amount of a mixture of cypress hot water extract, antibiotics, anti-inflammatory agents, etc. and attached to the wound. Further, the cypress hot water extract may be directly sprayed locally and covered with gauze or the like.
[0145]
(Test 9) Use effect test
The effect when the cosmetic composition of the present invention was actually used was examined. The use test is paneled by 10 people aged 30 to 60 years old who are suffering from stains, buckwheat, and dark-skinned, and each day, twice in the morning and at night, after face washing, the appropriate amount of the emulsion of Formulation Example 1 is applied to the face for 3 months. This was done by coating. In addition, the thing which remove | excluded each plant extract of this invention from the emulsion by the same method was used for the control. The evaluation method is based on the following criteria, and the results are as shown in Table 1. The numerical values in the table represent the number of people. No one complained of skin abnormalities during the period of use.
[0146]
“Blemish / Sobacus & Skin Color Improvement”
Effective: Blemish and freckles and skin color improved to white.
Slightly effective: Blemish freckles and skin color improved to white.
Invalid: No change before use.
[0147]
<Table 1>

[0148]
(Test results)
As shown in Table 1, it was confirmed that the cosmetic composition containing the cypress extract of the present invention significantly improved spots and freckles and also improved the skin color to white.
[0149]
(Test 10) Use effect test
The effect at the time of actually using the skin care cosmetic composition of this invention was examined. The test is glossy, unskinned skin and / or people suffering from eczema, acne, rough skin, 10 to 30 years old each as a panelist, daily, twice daily in the morning and night, after washing the face, the appropriate amount of the emulsion of Formulation Example 1 Was applied to the face for 3 months. In addition, the thing which remove | excluded each plant extract of this invention from the emulsion by the same method was used for the control. Moreover, the evaluation method is performed according to the following criteria, and the results are as shown in Tables 2 and 3, and the numerical values in the tables represent the number of people. No one complained of skin abnormalities during the period of use.
[0150]
"Skin feel improvement effect"
Effective: Increased skin gloss and tension.
Slightly effective: Skin gloss / tension increased slightly.
Invalid: No change before use.
[0151]
<Table 2>

[0152]
"Eczema / rough skin improvement effect"
Effective: Eczema, acne and rough skin were improved.
Slightly effective: Eczema, acne, rough skin were slightly improved.
Invalid: No change before use.
[0153]
<Table 3>

[0154]
(Test results)
As shown in Tables 2 and 3, it was confirmed that the cosmetic composition containing the cypress extract of the present invention has increased skin gloss and tension and improved eczema, acne and rough skin.
[0155]
【The invention's effect】
Melanin production inhibitor, active oxygen scavenger, lipid peroxide production inhibitor, lipase activity inhibitor, antiallergic agent, histamine release inhibitor or cosmetic composition containing the cypress extract of the present invention is a melanin pigment Significantly suppress generation and have a whitening effect. In addition, active oxygen should be significantly eliminated and suppressed, and lipid peroxide formation or lipase activity should be suppressed. Furthermore, the histamine release inhibitory action was confirmed.
And to improve spots and freckles, and to improve the skin color to white. In addition, it can improve eczema, acne and rough skin, and can also give skin gloss and tension, and is safe for humans and animals. The present invention can be used for other general foods and drinks.
[Brief description of the drawings]
BRIEF DESCRIPTION OF DRAWINGS FIG. 1 is a diagram showing the melanin production inhibitory action of a cypress extract of the present invention.
FIG. 2 is a diagram showing the active oxygen scavenging action of the cypress extract of the present invention.
FIG. 3 is a diagram showing the lipid peroxide production inhibitory action of the cypress extract of the present invention.
FIG. 4 is a graph showing the lipase activity inhibitory action of the cypress extract of the present invention.
FIG. 5 is a graph showing the histamine release inhibitory action of the cypress extract of the present invention.

Claims (1)

A lipase activity inhibitor comprising a cypress extract.

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