JP4671231B2 - Method for producing fluorene derivative - Google Patents

Description

The present invention relates to a method for producing a fluorene derivative useful as a raw material for polyester, polyurethane, polycarbonate, epoxy resin, modified acrylic resin and the like.

In recent years, fluorene derivatives such as 9,9-bis (4- (2-hydroxyethoxy) phenyl) fluorene have been promising as polymer raw materials having excellent heat resistance and transparency and a high refractive index. Optical lenses and films It is expected as a raw material for plastic optical fibers, optical disk substrates, heat resistant resins and engineering plastics.

As a method for producing 9,9-bis (4- (2-hydroxyethoxy) phenyl) fluorene, a method of dehydrating and condensing fluorenone and phenoxyethanol using sulfuric acid and thiol as catalysts is disclosed (Patent Document 1). However, since a large amount of sulfuric acid is used in this method, a complicated operation is required for purification after the reaction, and a large amount of neutralized wastewater is discharged. Further, when the sulfur component derived from the catalyst is mixed into the product, problems such as coloring of the product, deterioration of stability, and deterioration of purity occur. Furthermore, in order to obtain a high-purity product such as an optical resin raw material, it is necessary to repeat purification in order to remove sulfur, and this is not an industrially advantageous method.

As a method not using sulfuric acid, a method using metal exchange montmorillonite is disclosed (Patent Document 2). However, in this method, it is necessary to produce a metal-substituted montmorillonite catalyst by reacting commercially available montmorillonite with a metal chloride or the like. In order to increase the reaction yield, thiols such as β-mercaptopropionic acid are used as a co-catalyst, and since sulfur is mixed in the product, purification operation is required to obtain a high-purity product. Therefore, it is not an industrially advantageous method.

JP-A-7-165657

JP 2000-191577

The present invention provides a method for industrially producing a high-quality product free from sulfur without performing complicated catalyst removal operations and purification operations in the production of fluorene derivatives by the reaction of fluorenones and phenoxy alcohols. The purpose is to provide.

As a result of intensive studies to solve the above problems, the present inventors can produce a high-quality fluorene derivative in a high yield by reacting fluorenones and phenoxy alcohols in the presence of a heteropolyacid catalyst. As a result, the present invention has been completed.

（式中、Ｒ_１ａおよびＲ_１ｂは置換基を示す。ｋ１およびｋ２は０又は１〜４の整数を示し、同一もしくは異なっていてもよい。）
で表されるフルオレノン類と式（２）

（式中、Ｒ_３はアルキレン基、Ｒ_２は置換基を示す。ｎは０又は１以上の整数を示し、ｍは０又は１〜４の整数を示す。）
で表される化合物を反応させることを特徴とする、式（３）

（式中、Ｒ_３ａおよびＲ_３ｂはアルキレン基を示し、Ｒ_１ａＲ_１ｂ、Ｒ_２ａおよびＲ_２ｂは置換基を示す。ｋ１およびｋ２は０又は１〜４の整数を示し、同一もしくは異なっていてもよい。ｎ１およびｎ２は０又は１以上の整数を示し、同一もしくは異なっていてもよい。ｍ１およびｍ２は０又は１〜４の整数を示し、同一もしくは異なっていてもよい。）
で表されるフルオレン誘導体の製造方法に関する。 That is, the present invention provides a compound of formula (1) in the presence of a heteropolyacid catalyst.

(In the formula, R _1a and R _1b represent substituents. K1 and k2 represent 0 or an integer of 1 to 4, and may be the same or different.)
Fluorenones represented by the formula (2)

(In the formula, R ₃ represents an alkylene group, R ₂ represents a substituent. N represents 0 or an integer of 1 or more, and m represents 0 or an integer of 1 to 4.)
A compound represented by the formula (3):

(In the formula, R _3a and R _3b represent an alkylene group, R _1a R _1b , R _2a and R _2b represent a substituent. K1 and k2 represent 0 or an integer of 1 to 4, and are the same or different. N1 and n2 represent 0 or an integer of 1 or more and may be the same or different.m1 and m2 represent 0 or an integer of 1 to 4 and may be the same or different.)
The manufacturing method of the fluorene derivative represented by these.

The heteropolyacid used in the present invention is generally a complex oxide acid composed of two or more different oxide complexes, and a part or all of these protons replaced with other cations. Heteropolyacids include, for example, oxyacid ions of elements such as phosphorus, arsenic, tin, silicon, titanium, and zirconium (for example, phosphoric acid and silicic acid) and oxyacid ions of elements such as molybdenum, tungsten, vanadium, niobium, and tantalum. (Vanadic acid, molybdic acid, tungstic acid) and various heteropolyacids are possible depending on the combination thereof.

The element of oxygen acid constituting the heteropolyacid is not particularly limited, but for example, copper, beryllium, boron, aluminum, carbon, silicon, germanium, tin, titanium, zirconium, cerium, thorium, nitrogen, phosphorus, arsenic , Antimony, vanadium, niobium, tantalum, chromium, molybdenum, tungsten, uranium, selenium, tellurium, manganese, iodine, iron, cobalt, nickel, rhodium, osmium, ildium, platinum, and the like. A preferred heteropolyacid contains at least one element selected from phosphorus, silicon, vanadium, molybdenum and tungsten, and more preferably at least one element selected from phosphorus or silicon and vanadium, molybdenum and tungsten. Element.

As the heteropolyacid anion constituting the heteropolyacid skeleton, those having various compositions can be used. For _example, such _{XM 12 O 40, XM 12 O} 42, XM 18 O 62, XM 6 O 24 and the like. A preferred heteropolyacid anion composition is XM ₁₂ O ₄₀ . In each formula, X is an element such as silicon or phosphorus, and M is an element such as vanadium, molybdenum, or tungsten. Specific examples of heteropolyacids having these compositions include phosphomolybdic acid, phosphotungstic acid, silicomolybdic acid, silicotungstic acid, and phosphovanadomolybdic acid.

The heteropolyacid may be a free heteropolyacid, and may be used as a salt of a heteropolyacid by replacing some or all of the protons with other cations. Accordingly, the heteropolyacid referred to in the present invention includes salts of these heteropolyacids. Examples of cations that can be substituted with protons include ammonium, alkali metals, alkaline earth metals, and the like.

The heteropolyacid may be an anhydride or a crystal water-containing product, but the anhydride is preferred because the reaction is faster and the formation of by-products is suppressed. In the case of a crystal water-containing material, effects similar to those of the anhydride can be obtained by performing dehydration treatment such as drying under reduced pressure or azeotropic dehydration with a solvent in advance. The heteropolyacid may be used in a form supported on a support such as activated carbon, alumina, silica-alumina, or diatomaceous earth. These heteropolyacids may be used alone or in combination of two or more. Moreover, you may use together other catalysts other than heteropoly acid in the range which does not impair the objective of this invention as needed.

The amount of heteropolyacid used is not particularly limited, but in order to obtain a sufficient reaction rate, it is 0.0001 times by weight or more, preferably 0.001 to 30 times by weight with respect to the raw material fluorenone, More preferably, it is 0.01-5 weight times.

The fluorenones represented by the formula (1) correspond to the fluorene skeleton of the fluorene derivative represented by the formula (3). In the formula, the substituent represented by R _1a and R _1b is not particularly limited, and examples thereof include 1 to 1 carbon atoms such as a methyl group, an ethyl group, a propyl group, a butyl group, and a t-butyl group. 20 alkyl groups, cyclopentyl groups, cyclohexyl groups, etc., C5-C16 cycloalkyl groups, phenyl groups, alkylphenyl groups, etc., C6-C16 aryl groups, benzyl groups, phenethyl groups, etc., 7-carbon atoms 16 aralkyl groups, methoxy groups, ethoxy groups and other C1-C12 alkoxy groups, acetyl groups and other C1-C12 acyl groups, methoxycarbonyl groups and other C1-C12 alkoxycarbonyl groups, fluorine Examples thereof include halogen atoms such as atoms and chlorine atoms, nitro groups, and cyano groups. Preferably they are a C1-C6 alkyl group, a C1-C6 alkoxy group, a C6-C10 cycloalkyl group, a C6-C10 aryl group, More preferably, it is an alkyl group. . Of the alkyl groups, a methyl group is particularly preferred. R _1a and R _1b may be the same or different from each other. R _1a (or R _1b ) may be the same or different in the same benzene ring. In addition, the substitution position of R _1a (or R _1b ) is not particularly limited. The number of substituents k1 and k2 is 0 or 1 to 4, preferably 0 or 1, and more preferably 0. k1 and k2 may be the same or different, but are usually the same. Typical fluorenones include 9-fluorenone.

The compound represented by the formula (2) (phenoxy alcohols) corresponds to the phenoxy alcohol group substituted at the 9-position in the fluorene derivative represented by the formula (3), and R ₂ represents R _2a or to R _{2b, R 3} to _{R 3a} or _{R 3b,} m is the m1 or m @ 2, n respectively correspond to n1 or n2.

Although it does not specifically limit as a substituent represented by R _{< 2a>} and R _<2b> , For example, C1-C20 alkyl, such as a methyl group, an ethyl group, a propyl group, a butyl group, t-butyl group Aralkyl having 7 to 16 carbon atoms such as a cycloalkyl group having 5 to 16 carbon atoms such as a group, a cyclopentyl group and a cyclohexyl group, an aryl group having 6 to 16 carbon atoms such as a phenyl group and an alkylphenyl group, a benzyl group and a phenethyl group. Group, alkoxy group having 1 to 12 carbon atoms such as methoxy group and ethoxy group, acyl group having 1 to 12 carbon atoms such as acetyl group, alkoxycarbonyl group having 1 to 12 carbon atoms such as methoxycarbonyl group, fluorine atom, chlorine atom And halogen atoms such as nitro group, cyano group and the like. Preferred are an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, a cycloalkyl group having 6 to 10 carbon atoms, and an aryl group having 6 to 10 carbon atoms. R _2a and R _2b may be the same or different from each other, but are usually the same. R _2a (or R _2b ) may be the same or different in the same benzene ring. In addition, the substitution position of R _2a (or R _2b ) is not particularly limited. The number of substituents m1 and m2 is 0 or 1 to 4, preferably 0 to 2, and more preferably 0. m1 and m2 may be the same or different, but are usually the same.

The alkylene group represented by R _3a and R _3b is not particularly limited, and examples thereof include an ethylene group, a propylene group, a trimethylene group, a tetramethylene group, and a hexamethylene group. Preferably it is a C1-C6 alkylene group, More preferably, it is a C2-C3 alkylene group. R _3a and R _3b may be the same or different from each other, but are usually the same. The substitution position of R _3a (or R _3b ) is not particularly limited. The number of substituents n1 and n2 is 0 or 1 or more and may be the same or different. Preferably it is 0-15, More preferably, it is 0-5. In addition, when n1 (or n2) is 2 or more, the polyalkoxy group may be composed of the same alkoxy group, or a mixture of different types of alkoxy groups (for example, ethoxy group and propyleneoxy group). However, it is usually composed of the same alkoxy group.

Specific examples of the compound represented by the formula (2) include, for example, n = 0 compounds such as phenol, 2-methylphenol, 3-methylphenol, alkylphenols, 2,3-xylenol, 2,6, and the like. -Dialkylphenols such as xylenol and 3,5-xylenol, alkoxyphenols such as 2-methoxyphenol and 2-ethoxyphenol, and phenylphenols such as 2-phenylphenol and 3-phenylphenol. Examples of compounds with n = 1 include phenoxyalkyl alcohols such as phenoxyethanol, phenoxypropanol, and phenoxybutanol, (2-methyl-phenoxy) ethanol, (3-methyl-phenoxy) ethanol, (3-ethyl-phenoxy) ethanol, (3- Butyl-phenoxy) ethanol, (2-methyl-phenoxy) propanol, alkylphenoxyalkyl alcohols such as (3-methyl-phenoxy) propanol, (2,3-dimethylphenoxy) ethanol, (2,5-dimethylphenoxy) ethanol, Dialkylphenoxyalkyl alcohols such as (2,6-dimethylphenoxy) ethanol, (2,6-dibutylphenoxy) ethanol, and alkoxyphenes such as (2-methoxyphenoxy) ethanol. Alkoxyalkyl alcohols, (2-cyclohexyl-phenoxy) cycloalkyl phenoxyalkyl alcohols such as ethanol, an aryl phenoxyalkyl alcohols such biphenylyloxy ethanol. Examples of the compound having n of 2 or more include polyoxyalkylene phenyl ethers corresponding to these phenoxyalkyl alcohols. Preferred is phenoxy C _2-6 alkyl alcohol or C _1-4 alkylphenoxy C _2-6 alkyl alcohol, and particularly preferred is phenoxyethanol.

The amount of the compound represented by the formula (2) is not particularly limited, but it is generally 2 to 50 mol, preferably 1 to 1 mol with respect to 1 mol of fluorenone from the viewpoint of side reaction suppression and economy. Is 2.5 to 20 mol, more preferably 3 to 10 mol. Moreover, these compounds can also be used as a reaction solvent.

The method for synthesizing the fluorene derivative in the present invention is not particularly limited, but usually, the raw material fluorenones and phenoxy alcohols, and the heteropolyacid catalyst are charged into the reaction apparatus, and in the air or inert such as nitrogen or helium. It can be performed by heating and stirring in the presence or absence of an inert solvent such as toluene or xylene under a gas atmosphere.
At this time, by removing the water in the reaction system, such as catalyst-containing water and reaction product water, by performing the reaction under dehydrating conditions, the reaction proceeds faster than when not dehydrating, and the production of by-products is suppressed, The target product can be obtained with higher yield. The dehydration method is not particularly limited, and examples thereof include dehydration by adding a dehydrating agent, dehydration by reduced pressure, dehydration by azeotropy with a solvent under normal pressure or reduced pressure, and the like.

Although it does not specifically limit as a dehydrating agent used for reaction, A molecular sieve, sodium sulfate, magnesium sulfate, etc. are mentioned. The amount of the dehydrating agent is not particularly limited, but from the viewpoint of dehydrating effect and economy, it is usually 0.0001 times by weight or more, preferably 0.001 to 100 times by weight, more preferably fluorenone. 0.01 to 50 times by weight.

The azeotropic dehydration solvent used in the reaction is not particularly limited, but aromatic hydrocarbons such as toluene and xylene, halogenated aromatic hydrocarbons such as chlorobenzene and dichlorobenzene, pentane, hexane and heptane. Aliphatic hydrocarbons such as dichloromethane, halogenated hydrocarbons such as dichloromethane and 1,2-dichloroethane, aliphatic and cyclic such as diethyl ether, di-iso-propyl ether, methyl-t-butyl ether, diphenyl ether, tetrahydrofuran and dioxane Ethers, esters such as ethyl acetate and butyl acetate, nitriles such as acetonitrile, propionitrile, butyronitrile and benzonitrile, N, N-dimethylformaldehyde, N, N-dimethylacetaldehyde, 1-methyl-2-pyrrole And amines such as non thereof. Preferred are aromatic hydrocarbons and halogenated aromatic hydrocarbons, and more preferred are toluene, xylene, chlorobenzene and dichlorobenzene. Although the amount of use is not particularly limited, from the economical point of view, it is usually 0.1 times or more, preferably 0.5 to 100 times, more preferably 1 to 20 times the weight of the fluorenone. is there.
The reaction temperature varies depending on the raw materials used and the type of solvent, but is usually 50 to 300 ° C, preferably 80 to 250 ° C, and more preferably 120 to 180 ° C. The reaction can be followed by analytical means such as liquid chromatography.

A fluorene derivative can be obtained as a crystal by adding a solvent to the reaction solution after the reaction and crystallization by cooling, and the precipitated crystal is recovered by filtration or the like. If necessary, purification operations such as washing, adsorption, steam distillation, and recrystallization can be performed. As the solvent used for crystallization and purification, the reaction solvent may be used as it is, or another solvent may be used. Crystallization solvents include aliphatic lower alcohols such as methanol, ethanol and propanol, aliphatic lower ketones such as acetone and methyl ethyl ketone, aromatic hydrocarbons such as toluene and xylene, esters such as ethyl acetate, water, etc. Is particularly preferred.

Examples of the fluorene derivative represented by the formula (3) produced in the present invention include 9,9-bis (hydroxy (poly) alkoxyphenyl) fluorene and 9,9-bis (hydroxy (poly) alkoxy-alkyl. Phenyl) fluorene, 9,9-bis (hydroxy (poly) alkoxy-dialkylphenyl) fluorene, 9,9-bis (hydroxy (poly) alkoxy-alkoxyphenyl) fluorene, 9,9-bis (hydroxy (poly) alkoxy- Cycloalkylphenyl) fluorene, 9,9-bis (hydroxy (poly) alkoxy-arylphenyl) fluorene, and the like. Among these fluorene derivatives, the present invention is effective in the production of 9,9-bis (hydroxy (poly) alkoxyphenyl) fluorene, particularly in the production of 9,9-bis (4- (2-hydroxyethoxy) phenyl) fluorene. It is.

When producing a fluorene derivative from fluorenones and phenoxy alcohols, it is possible to provide a method for producing an industrially advantageous production of a high-quality fluorene derivative that does not contain sulfur without complicated catalyst removal and purification operations. .

(Example)
The present invention will be described in more detail with reference to examples below, but the present invention is not limited thereto.

In a glass reactor equipped with a stirrer, a nitrogen blowing tube, a thermometer and a cooling tube, 54.0 g (0.300 mol) of fluorenone, 330.0 g (2.388 mol) of phenoxyethanol and phosphotungstic acid [(H ₃ 5.4 g of PW ₁₂ O ₄₀ ) · nH ₂ O] was added, and the mixture was stirred for about 2 hours under a nitrogen atmosphere while maintaining the temperature at 170 ° C. As a result of analyzing the obtained reaction liquid by high performance liquid chromatography, 11,2.5 g (0.257 mol) of 9,9-bis (4- (2-hydroxyethoxy) phenyl) fluorene was produced.

In a glass reactor equipped with a stirrer, a nitrogen blowing tube, a thermometer and a cooling tube, 18.0 g (0.100 mol) of fluorenone, 550.0 g (3.980 mol) of phenoxyethanol and silicotungstic acid [(H ₄ 15.0 g of SiW ₁₂ O ₄₀ ) · nH ₂ O] was added, and the mixture was stirred for about 16 hours under a nitrogen atmosphere while maintaining the temperature at 140 ° C. As a result of analyzing the obtained reaction liquid by high performance liquid chromatography, 9,7.0 g (0.084 mol) of 9,9-bis (4- (2-hydroxyethoxy) phenyl) fluorene was produced.

In a glass reactor equipped with a stirrer, a nitrogen blowing tube, a thermometer and a cooling tube, 18.0 g (0.100 mol) of fluorenone, 220.0 g (1.592 mol) of phenoxyethanol and phosphomolybdic acid [(H ₃ PMo ₁₂ O ₄₀ ) · nH ₂ O] 7.5 g was added, and the mixture was stirred for about 4 hours under a nitrogen atmosphere while maintaining the temperature at 170 ° C. As a result of analyzing the obtained reaction liquid by high performance liquid chromatography, 3,4.4 g (0.078 mol) of 9,9-bis (4- (2-hydroxyethoxy) phenyl) fluorene was produced.

In a glass reactor equipped with a stirrer, a nitrogen blowing tube, a thermometer and a cooling tube, 54.0 g (0.300 mol) of fluorenone, 330.0 g (2.388 mol) of phenoxyethanol and phosphovanadomolybdic acid [(H ₇ PV ₄ Mo ₈ O ₄₀ ) · nH ₂ O] was added, and the mixture was stirred for about 4 hours under a nitrogen atmosphere while maintaining the temperature at 170 ° C. As a result of analyzing the obtained reaction liquid by high performance liquid chromatography, 9,9.0 g (0.249 mol) of 9,9-bis (4- (2-hydroxyethoxy) phenyl) fluorene was produced.

In a glass reactor equipped with a stirrer, a nitrogen blowing tube, a thermometer and a cooling tube, 18.0 g (0.100 mol) of fluorenone, 550.0 g (3.980 mol) of phenoxyethanol and sodium phosphotungstate [(Na ₃ PW ₁₂ O ₄₀ ) · nH ₂ O] was added, and the mixture was stirred for about 4 hours under a nitrogen atmosphere while maintaining the temperature at 170 ° C. As a result of analyzing the obtained reaction liquid by high performance liquid chromatography, 9.9 g (0.023 mol) of 9,9-bis (4- (2-hydroxyethoxy) phenyl) fluorene was produced.

In a glass reactor equipped with a stirrer, a nitrogen blowing tube, a thermometer and a cooling tube, 0.90 g (0.005 mol) of fluorenone and 4.99 g of 1- (2-methyl-phenoxy) -2-propanol (0.030). Mol), 4 g of xylene and 0.7 g of phosphotungstic acid [(H ₃ PW ₁₂ O ₄₀ ) · nH ₂ O] as a catalyst were added, and the mixture was stirred for about 4 hours under a nitrogen atmosphere while maintaining the temperature at 160 ° C. As a result of analyzing the obtained reaction liquid by high performance liquid chromatography, 1.85 g (0.0037 mol) of 9,9-bis (4- (2-hydroxypropoxy) -3-methyl-phenyl) fluorene was produced. It was.

In a glass reactor equipped with a stirrer, nitrogen blowing tube, thermometer and cooling tube, 10.0 g (0.056 mol) of fluorenone, 30.0 g (0.319 mol) of phenol and phosphotungstic acid [(H ₃ PW ₁₂ O ₄₀ ) · nH ₂ O] 2.0 g was added, and the mixture was stirred for about 10 hours under a nitrogen atmosphere while maintaining the temperature at 140 ° C. As a result of analyzing the obtained reaction solution by high performance liquid chromatography, 17.2 g (0.049 mol) of 9,9-bis (4-hydroxyphenyl) fluorene was produced.

In a glass reactor equipped with a stirrer, a nitrogen blowing tube, a thermometer and a cooling tube, 10.0 g (0.056 mol) of fluorenone, 36.7 g (0.339 mol) of o-cresol and phosphotungstic acid [( H ₃ PW ₁₂ O ₄₀ ) · nH ₂ O] was added, and the mixture was stirred for about 5 hours under a nitrogen atmosphere while maintaining the temperature at 160 ° C. As a result of analyzing the obtained reaction liquid by high performance liquid chromatography, 18.5 g (0.049 mol) of 9,9-bis (4-hydroxy-2-methyl-phenyl) fluorene was produced.

In a glass reactor equipped with a water separator equipped with a stirrer, a nitrogen blowing tube, a thermometer and a condenser, fluorenone 86.4 g (0.48 mol), phenoxyethanol 397.9 g (2.88 mol), toluene 350 g and 4.3 g of phosphotungstic acid [(H ₃ PW ₁₂ O ₄₀ )], which was dried at 100 ° C. under reduced pressure to remove water of crystallization, was added, and the mixture was stirred for 12 hours while refluxing toluene and removing the generated water from the reaction system. As a result of analyzing the obtained reaction liquid by high performance liquid chromatography, 19,7.3 g (0.45 mol) of 9,9-bis (4- (2-hydroxyethoxy) phenyl) fluorene was produced. Toluene (300 g) was added to the reaction solution, and the mixture was washed with water at 80 ° C. using 100 g of water. Next, this liquid was gradually cooled to room temperature, and the precipitated crystals were filtered and dried to obtain 158.0 g of white crystals [9,9-bis (4- (2-hydroxyethoxy) phenyl) fluorene] (yield 75.75). 1%, LC purity 99.0%). The sulfur content in the obtained crystal was 0.2 ppm or less.

In a glass reactor equipped with a water separator equipped with a stirrer, a nitrogen blowing tube, a thermometer and a condenser, fluorenone 86.4 g (0.48 mol), phenoxyethanol 663.2 g (4.80 mol), toluene 350 g and 4.3 g of silicotungstic acid [(H ₄ SiW ₁₂ O ₄₀ )], which was dried under reduced pressure at 100 ° C. to remove crystal water, was added, and the mixture was stirred for 8 hours while removing the produced water out of the reaction system under reflux of toluene. As a result of analyzing the obtained reaction liquid by high-performance liquid chromatography, 201.5 g (0.46 mol) of 9,9-bis (4- (2-hydroxyethoxy) phenyl) fluorene was produced. Toluene (300 g) was added to the reaction solution, and the mixture was washed with water at 80 ° C. using 100 g of water. Subsequently, toluene and excess phenoxyethanol were removed by concentration under reduced pressure under heating. To this concentrated liquid was added 600 g of toluene, and the mixture was heated and stirred at 80 ° C. for about 1 hour, and then gradually cooled to room temperature. The precipitated crystals were filtered and dried to obtain white crystals [9,9-bis (4- (2 -Hydroxyethoxy) phenyl) fluorene], 162.1 g (92.0% yield, 96.2% LC purity). The sulfur content in the obtained crystal was 0.2 ppm or less.

(Comparative Example 1)
A glass reactor equipped with a stirrer, a nitrogen blowing tube, a thermometer and a cooling tube was charged with 45.0 g (0.25 mol) of fluorenone, 138.0 g (1.00 mol) of phenoxyethanol, and 0.2 ml of α-mercaptopropionic acid. In addition, evenly dissolved. To this solution, 45 ml of 95% sulfuric acid was added dropwise over about 30 minutes, followed by stirring at 65 ° C. for 4 hours. Toluene 360g was added to the obtained reaction liquid, and water washing was repeated 3 times at 80 degreeC using 90g of water. Next, this liquid was gradually cooled to room temperature, and the precipitated crystals were filtered and dried to give 81.8 g of light yellow crystals [9,9-bis (4- (2-hydroxyethoxy) phenyl) fluorene] (yield 74). 8%). The sulfur content in the crystals was 600 ppm. Further, the crystals were dissolved in 523 g of toluene, 1.6 g of activated carbon and 4.1 g of anion exchange resin (Duolite A-378, manufactured by Sumitomo Chemical Co., Ltd.) were added, and the mixture was heated and stirred at 80 ° C. for about 1 hour. And the ion exchange resin was removed. The obtained filtrate was gradually cooled to room temperature, and the precipitated crystals were filtered and dried to obtain 71.6 g (yield 65.2%) of white crystals. The sulfur content in the crystals was 55 ppm.

Claims (5)

Fluorenone and formula (2) in the presence of a heteropolyacid catalyst

(In the formula, R ₃ represents an alkylene group having 2 to 6 carbon atoms, R ₂ represents an alkyl group having 1 to 6 carbon atoms, n represents 0 or an integer of 1 to 5, and m represents 0 or 1 to 2). The compound represented by formula (3) is reacted with a compound represented by formula (3)

_{(Wherein, R 3a} and _{R 3b} represents an alkylene group having 2 to 6 carbon _{atoms, R 2a} and _{R 2b} are the .n ₁ and _{n 2} are 0 or 1 to 5 represents an alkyl group having 1 to 6 carbon atoms An integer, which may be the same or different, and m ₁ and m _{2 each} represents 0 or an integer of 1 to _2, and may be the same or different . 2. The process according to claim 1, wherein a dehydration-conditioning reaction is performed between the fluorenone and the compound represented by the formula (2) in the presence of a heteropolyacid catalyst. Formula (2) is a phenoxyethanol, The manufacturing method of the fluorenone derivative | guide_body of Claims 1-2 . The method for producing a fluorenone derivative according to claim 1, wherein the heteropolyacid contains at least one element selected from phosphorus or silicon and vanadium, molybdenum and tungsten as constituent elements. Heteropolyacid catalyst is, anhydrides of heteropoly acid, or method of claims 1 to 4 fluorenone derivatives, wherein it is pre-dehydrated heteropoly acid.