JP4666951B2 - Blister packaging machine and pharmaceutical solid preparation - Google Patents

Description

The present invention belongs to a technical field including a blister packaging machine used for producing a pharmaceutical solid preparation and a blister sheet in which the pharmaceutical solid preparation is packaged.

  On tablets such as pharmaceuticals, information on characters such as symbols indicating manufacturers, numbers representing tablet types, and alphabets is printed or stamped on the surface. There is a limit to the amount of information that can be printed on the small surface area of a tablet, and it is not possible to have a large amount of information. Under such circumstances, it may be difficult to specify the type of tablet only by the printed information.

  On the other hand, in recent years, there is a need for pharmaceutical products to have various information such as product name, content, identification code, and expiration date in order to prevent traceability and handling errors. It is possible to display such a large amount of information on a box or the like for packaging a pharmaceutical product, but it is preferable to give such information to individual tablets taken out of the box.

  Furthermore, there is a need to detect mixing of different varieties in the process of packaging a tablet on a blister sheet or the like based on information that the tablet individually has.

Therefore, by printing a two-dimensional code such as a QR code on the surface of the tablet, more information is given to the tablet, and in the blister packaging process, mixing of different varieties is detected by an inspection device using an image processing device. (For example, refer to Patent Document 1).
JP 2001-64160 A

  However, even when a two-dimensional code is applied, in order to give a large amount of information, it is necessary to perform precise printing. To print within a small surface area of a tablet, a very advanced technology Cost. Alternatively, there is a possibility that the amount of information is still not sufficient with a two-dimensional code at a level that allows easy printing.

  Moreover, there is a possibility that the tablet surface may be damaged, and it is feared that the printed information cannot be read accurately due to the damage.

Therefore, the present invention has been made in view of the above circumstances, and it is certain that the pharmaceutical solid preparation capable of individually providing necessary and sufficient information, the type of the pharmaceutical solid preparation to which the information is attached, and the like. An object of the present invention is to provide a blister packaging machine that can be inspected.

  In the following, each means suitable for solving the above-mentioned purpose will be described in terms of items. In addition, the effect etc. peculiar to the means to respond | correspond as needed are added.

Means 1. A blister packaging machine for packaging a pharmaceutical solid preparation in which IC tags each storing predetermined information are individually embedded into a blister sheet,
Reading means for reading the information stored in the IC tag of the pharmaceutical solid preparation ;
A pharmaceutical solid preparation testing device having an information processing means for processing the read information,
The IC tag stores at least information capable of specifying the type of pharmaceutical solid preparation ,
The blister packaging machine, wherein the information processing means includes a correct / incorrect determination unit that determines whether or not the solid pharmaceutical preparation whose information has been read is a different product based on the read information.

According to the said means 1, the pharmaceutical solid formulation packaged by a blister sheet | seat with a blister packaging machine has individually the IC tag in which the predetermined information was memorize | stored. Since a relatively large amount of information can be stored in the IC tag, necessary information can be given to individual pharmaceutical solid preparations . The blister packaging machine is provided with a pharmaceutical solid preparation inspection device. When inspecting the pharmaceutical solid preparation by the pharmaceutical solid preparation inspection device, by the reading means, information of the IC tag included in each pharmaceutical solid preparation is read. By processing the read information by the information processing means, it is possible to confirm the information content and to inspect the pharmaceutical solid preparation . For this reason, even if it is the same or the same pharmaceutical solid formulation with the external appearance difficult to judge by an external appearance test | inspection, a pharmaceutical solid formulation can be test | inspected reliably by the read information content.

In addition, it is determined whether or not the information of the IC tag read by the reading unit is correct by a correct / incorrect determination unit provided in the information processing unit. Thereby, it can be reliably determined whether or not the pharmaceutical solid preparation having the IC tag is genuine .

The IC tag stores information that can identify the type of solid pharmaceutical preparation . For this reason, the correct / incorrect determination unit can determine whether the solid pharmaceutical preparation whose information has been read is a correct product type or a different product type, and can detect the mixing of different product types.

Mean 2. The blister packaging machine according to means 1, wherein the reading means can read the information stored in the IC tag for each individual pharmaceutical solid preparation .

According to the means 2, the information stored in the IC tag can be read for each individual pharmaceutical solid preparation by the reading means. Thereby, since individual pharmaceutical solid preparations can be distinguished, more precise management and the like can be performed.

Means 3. The blister packaging machine according to means 2, wherein the reading means includes a shield for blocking reading of information corresponding to adjacent pharmaceutical solid preparations .

According to the means 3, the reading of information corresponding to adjacent pharmaceutical solid preparations is blocked by the shield. For this reason, the malfunction that the information of an adjacent pharmaceutical solid formulation is read accidentally can be suppressed. Therefore, it is possible to perform an inspection in which individual pharmaceutical solid preparations are reliably distinguished.

Means 4. A filling device for filling the pharmaceutical solid preparation in the pocket portion of the packaging film;
The blister packaging machine according to any one of means 1 to 3, wherein the reading means reads information on the pharmaceutical solid preparation at least after filling by the filling device.

According to the means 4, the information on the pharmaceutical solid preparation is read by the filling device after the pharmaceutical solid preparation is filled in the pocket portion of the packaging film. For this reason, the pharmaceutical solid preparations are arranged in an orderly manner, and it is easy to read information by the reading means and to associate the information with the solid pharmaceutical preparation . In addition, it is possible to suppress problems such as that the pharmaceutical solid preparation is not filled with the pharmaceutical or the pharmaceutical solid preparation that has not been inspected is erroneously filled despite the inspection.

Means 5. The belt-shaped packaging film and the cover film to be attached to the packaging film are transported and configured to produce a blister sheet,
While installing the pharmaceutical solid preparation inspection device in the section for intermittent transfer of the band-like blister film after the packaging film or the cover film is attached,
The blister packaging machine according to means 4, wherein the reading means reads information on the pharmaceutical solid preparation at least during the stop of the film transfer.

According to the above means 5, when the blister sheet is produced by the blister packaging machine, the belt-shaped packaging film or the blister film having the cover film adhered to the packaging film is transferred. A pharmaceutical solid preparation inspection apparatus is installed in a section where the film transfer is intermittently performed. And the information of the pharmaceutical solid formulation with which the film is filled is read by the reading means while the transfer is stopped. For this reason, compared with the case where an information inspection apparatus is arrange | positioned in the area conveyed continuously, information reading time can fully be ensured and information can be read more reliably.

  Means 6. A means for sticking a cover film to a packaging film, wherein the reading means reads information from the packaging film side at least after the cover film is stuck by the sealing means. The blister packaging machine according to any one of the above.

According to the means 6, the information is read after the cover film is adhered to the packaging film by the sealing means. Accordingly, or worse a Ketsujo in pharmaceutical solid preparation pop-out after the information inspection, the problem that pharmaceutical solid preparation that has been inspected or got replaced with another pharmaceutical solid preparation can be suppressed. Also, information is read from the packaging film side. For this reason, when reading from the cover film side which consists of metal foils, there exists a possibility that a magnetic field, electromagnetic waves, etc. may be interrupted | blocked by the influence of metal foil, and read sensitivity may fall or it may not be able to read. In this regard, the means 6 can read information with relatively high sensitivity.

Mean 7 Any of the means 1 to 6, wherein the IC tag can write information after it is manufactured, and the pharmaceutical solid preparation testing device has a writing means for writing predetermined information to the IC tag. Blister packaging machine according to crab.

According to the means 7, since the IC tag can write information after manufacture, information can be written even during or after manufacture of the pharmaceutical solid preparation . When packaging in a blister sheet, predetermined information is written into the IC tag by the writing means. For this reason, at the time of blister sheet manufacture, by storing information in the pharmaceutical solid preparation , it is possible to suppress problems such as information previously stored in the IC tag being different from the information of the original pharmaceutical solid preparation .

  Means 8. The blister packaging machine according to means 7, wherein the writing means writes information relating to packaging.

  According to the means 8, the information relating to the packaging is written by the writing means. Examples of information relating to packaging include a packaging line and a packaging date. By writing such information, it is possible to easily perform post-processing for abnormalities related to packaging.

Means 9. A pharmaceutical solid preparation in which an IC tag storing information capable of identifying at least its own variety is embedded.

According to the means 9, the IC tag is embedded in the pharmaceutical solid preparation . Since a relatively large amount of information can be stored in the IC tag, necessary information can be given to individual pharmaceutical solid preparations . For this reason, it is possible to confirm the information of the solid pharmaceutical preparation after taking out from the packaging container or separating the pieces packaged in a blister sheet or the like. For this reason, the handling mistake at the time of storage of a pharmaceutical solid formulation , dosing, etc. can be suppressed. In addition, when a person who takes a solid pharmaceutical preparation is involved in a plurality of medical institutions, an appropriate prescription can be received. Furthermore, even after taking a solid pharmaceutical preparation , collect the IC tag discharged from the body, or read the information of the IC tag that remains in the body by swallowing the IC tag reader, etc. In this way, information on the solid pharmaceutical preparations taken can be obtained. Therefore, it is possible to confirm accidental ingestion, and it is possible to perform an immediate medical treatment at the time of accidental ingestion.

In addition, information that can identify the type of solid pharmaceutical preparation is stored in the IC tag. For this reason, even if it is the same pharmaceutical solid formulation with the same external shape which is hard to judge by an external appearance test | inspection, it can be reliably discriminate | determined whether it is different varieties by whether information is correct.

Means 10. The pharmaceutical solid preparation according to means 9, wherein the IC tag is coated to prevent erosion by digestive fluid.

According to the means 10, the coating prevents the IC tag from being eroded by the digestive fluid. For this reason, the safety | security with respect to the human body at the time of taking a pharmaceutical solid formulation can be improved.

Means 11. The pharmaceutical solid preparation according to means 9 or 10, wherein the IC tag is embedded without being exposed on the surface.

According to the above means 11, since the IC tag is not exposed on the surface of the pharmaceutical solid preparation, pharmaceutical solid preparations produced after step (e.g., transportation process, packaging process and the like) at the time and dose, IC tag is damaged It is possible to prevent problems such as trapping and IC tags falling off from pharmaceutical solid preparations . As a result, it is possible to suppress problems that the information cannot be confirmed or the safety at the time of taking is reduced.

Means 12. The pharmaceutical solid preparation according to any one of means 9 to 11, wherein the IC tag is embedded in the vicinity of the center of gravity.

According to the means 12, the IC tag is embedded in the vicinity of the center of gravity of the solid pharmaceutical preparation . For this reason, the deterioration of the weight balance with respect to the case where the IC tag is not embedded can be suppressed. Therefore, it is possible to suppress the occurrence of problems due to the poor weight balance in the process of transporting and packaging the solid pharmaceutical preparation .

Hereinafter, an embodiment will be described with reference to the drawings. As shown in FIG. 2, an IC tag 3 is embedded in the tablet ( pharmaceutical solid preparation ) 1 in the present embodiment. The IC tag 3 is completely embedded in the vicinity of the center, that is, in the vicinity of the center of gravity, and is covered with the coating layer 4 so as not to be exposed on the surface of the tablet 1 .

  The IC tag 3 is a tag capable of storing information and reading information using electromagnetic waves or the like in a non-contact manner, and is configured by an integrated circuit, an antenna, or the like provided with an information circuit for storing information for reading. Yes. The information is stored when the IC tag 3 itself is manufactured. Information stored in the IC tag 3 includes product name, identification code, content / titer, production number (lot number, production date), expiration date, usage method (time, quantity, interval, other notes), storage method Etc.

  The coating layer 4 is formed so as to cover the entire IC tag 3 in order to suppress damage to the IC tag 3. The coating layer 4 is made of a material that is highly safe to the human body without being eroded (corroded) by digestive fluid such as stomach acid. Examples of the material include ceramic and resin.

  As a package for packaging the tablet 1, there is a PTP sheet 5 as a blister sheet as shown in FIGS. 3 (a) and 3 (b). The PTP sheet 5 includes a packaging film 7 having a plurality of pocket portions 6 and a cover film 8 attached to the packaging film 7 so as to close the pocket portions 6. The packaging film 7 is made of, for example, a relatively hard thermoplastic resin material having a predetermined rigidity such as PP (polypropylene) or PVC (polyvinyl chloride), and is transparent or translucent. The cover film 8 is made of aluminum foil. Each pocket 6 contains one tablet 1 as the contents. In the present embodiment, the PTP sheet 5 is manufactured into a sheet shape by cutting or punching a strip-shaped PTP film formed from the strip-shaped packaging film 7 and the cover film 8.

  Next, a PTP packaging machine (blister packaging machine) 10 for producing the PTP sheet 5 will be described with reference to FIG. On the most upstream side of the PTP packaging machine 10, the strip-shaped packaging film 7 is wound in a roll shape. The packaging film 7 wound in a roll shape is intermittently conveyed, and the heating means 12 and the pocket forming means 13 are arranged in parallel along the conveyance path of the packaging film 7. ing. These heating means 12 and pocket forming means 13 constitute a pocket portion forming apparatus 14. Then, in the state where the packaging film 7 is partially heated by the heating device 12 and the packaging film 7 becomes relatively flexible, the pocket portion 6 is formed in the packaging film 7 by the pocket forming means 13. The pocket portion 6 is formed at an interval between transport operations of the packaging film 7.

  A filling device 16 for automatically filling the tablet 1 with the tablet 1, an appearance inspection device 17, and a sealing means 18 are disposed along the transfer path of the packaging film 7 in which the pocket portion 6 is formed. The filling device 16 drops the tablet 1 by opening the shutter at predetermined intervals, and the tablet 1 is put into each pocket portion 6 in accordance with the shutter opening operation. Since the IC tag 3 is embedded in the vicinity of the center of the tablet 1, the IC tag 3 does not deteriorate the weight balance of the tablet 1 so much. For this reason, when filling the filling device 16, the tablet 1 can be filled without stagnation.

  The appearance inspection device 17 is for inspecting whether or not the tablet 1 is securely filled in each pocket portion 6, whether or not there is an appearance abnormality such as chipping or cracking of the tablet 1, and the presence or absence of foreign matter. is there. The appearance inspection device 17 performs an inspection from the opening side of the pocket portion 6.

  On the other hand, the cover film 8 formed in a band shape is wound in a roll shape on the most upstream side. The drawing end of the cover film 8 wound in a roll shape is guided toward the sealing means 18. The sealing means 18 includes a film receiving roll 19 and a heating roll 20, and is configured so that the heating roll 20 can be pressed against the film receiving roll 19. The packaging film 7 and the cover film 8 are fed between the rolls 19 and 20. And the cover film 8 is stuck to the packaging film 7 because the packaging film 7 and the cover film 8 pass between both rolls 19 and 20 in a hot-pressing state, and thereby the tablet 1 is in each pocket portion. A PTP film 21 as a strip-shaped blister film filled in 6 is manufactured.

An information inspection device 22 as a pharmaceutical solid preparation inspection device for inspecting information stored in the IC tag 3 embedded in the tablet 1 is disposed downstream of the sealing means 18. This information check is also performed during the interval between the transport operations of the packaging film 7. The information inspecting device 22 inspects the tablet 1 for mixing of different varieties or missing tablets based on the information read from the IC tag 3. The detailed description of the information inspection apparatus 22 will be described later. The inspection result signals from the appearance inspection device 17 and the information inspection device 22 are sent to an information control device (not shown). The information control device manages the information of the tablet 1 and the inspection result and outputs an information signal. When a defective product is determined by the appearance inspection device 17 and the information inspection device 22, a defective product signal is sent to a defective sheet discharge mechanism (not shown) by the information control device, and the defective PTP sheet is determined as a defective sheet. Separately discharged by the discharge mechanism and transferred to a defective hopper (not shown).

  A slit forming device 24 and a sheet punching device 26 are arranged in this order along the PTP film 21 transfer path downstream of the information inspection device 22. The slit forming device 24 has a function of forming a slit at a predetermined position of the PTP film 21. The sheet punching device 26 has a function of punching the PTP film 21 in units of 5 PTP sheets. On the downstream side of the sheet punching device 26, a scrap hopper 28 for storing the end material 27 falling from the sheet punching device 26 is provided. Further, a conveyor 29 for transferring the punched PTP sheet 5 is provided below the sheet punching device 26, and the PTP sheet 5 is transferred to the finished product hopper 30. Yes.

  Here, the information inspection apparatus 22 will be described with reference to FIGS. 4 (a) and 4 (b). The information inspection apparatus 22 includes a reading unit 32 for reading information on the IC tag 3 and an information processing unit 33 for processing the read information.

  The reading means 32 is provided on the packaging film 7 surface side of the PTP film 21, and has a plurality of reading heads 35 and a base 36 to which the reading heads 35 are attached. For example, the reading head 35 reads information on the IC tag 3 in the tablet 1 by applying a magnetic field to the IC tag 3 and receiving an electromagnetic wave transmitted from the IC tag 3. Each reading head 35 corresponds to one tablet 1 and is configured to be able to read the information of the IC tag 3 in the tablet 1. In the present embodiment, one is provided corresponding to each row of the pocket portions 6 formed side by side in the width direction of the PTP film 21, that is, one row in the transfer direction of the PTP film 21.

  Further, the base 36 is provided with a shield 37 for preventing reading of information on the adjacent tablets 1. The shield 37 is formed to protrude from the base 36 toward the PTP film 21 so as to surround each reading head 35 and the pocket portion 6 filled with the tablet 1 targeted by the reading head 35. In the present embodiment, the shield 37 has a substantially lattice-shaped partition plate structure. Further, the base 36 incorporates a drive device (not shown), and can move toward and away from the PTP film 21 in synchronization with the transfer of the PTP film 21.

  The information processing means 33 compares the information stored in the information storage unit 38 with the information read by the reading means 32 and the information storage unit 38 for setting and storing information of the tablet 1 that should be originally stored. A correct / incorrect determination unit 39 that determines whether the read tablet 1 is a genuine product or an incorrect product (defective product), and the determination result of the correct / incorrect determination unit 39 indicates the information control device, a monitor (not shown), an alarm device, etc. Output unit 41 for outputting to the external device.

  Next, an inspection procedure and its operational effects when inspecting the information of the tablet 1 by the information inspection apparatus 22 will be described. While the intermittently transferred PTP film 21 is stopped, the base 36 is brought close to the PTP film 21. As a result, the reading head 35 is brought close to the tablet 1 and the shield 37 enters between the pocket portions 6. Information of the IC tag 3 in the tablet 1 is read by each reading head 35. At this time, the presence of the shield 37 enables the reading head 35 to read the information of the IC tag 3 in the corresponding tablet 1 without reading the information of the adjacent tablet 1 by mistake. When the reading is completed, the base 36 is separated from the PTP film 21. As a result, the shield 37 is completely separated from between the pocket portions 6. When the base 36 is separated, the PTP film 6 is transferred. At this time, since the base 36 is separated, the shield 37 contacts the pocket portion 6 of the PTP film 21 to which the shield 37 is transferred, and the pocket portion 6 is deformed or the tablet 1 in the pocket portion 6 is damaged. Or the like.

  On the other hand, the read information is compared with information stored in the information storage unit 38 by the correctness determination unit 39. That is, it is determined whether the product name, identification code, content / titer, production number, expiration date, usage method, storage method, and the like of the tablet 1 stored in the IC tag 3 match. Here, when the correct tablet 1 is filled, all the items match and are determined to be genuine. If a tablet that should not be filled is filled in the pocket portion 6 due to mixing of different varieties, etc., an inconsistent item is generated and it is determined that the product is a wrong product. Further, if there are items that cannot be read due to missing tablets or damage to the IC tag 3, the product is determined to be an incorrect product. The determination result is output by the output unit 41 to the information control apparatus.

  As described above in detail, in this embodiment, the IC tag 3 is embedded in the tablet 1. Since the IC tag 3 can store a relatively large amount of information, necessary information can be given to each tablet 1. For this reason, it becomes possible to confirm the information of the tablet 1 even after taking out from the packaging container or separating the pieces packaged in the PTP sheet or the like. For this reason, the handling mistake at the time of storage of the tablet 1 or medication can be suppressed. Moreover, when the user who takes the tablet 1 applies to a plurality of medical institutions, an appropriate prescription can be received.

  Further, even after taking the tablet 1, the IC tag 3 discharged from the body is collected, or the information of the IC tag 3 remaining in the body is read by swallowing the reader of the IC tag 3 or the like. By doing so, the information of the tablet 1 taken can be obtained. Therefore, it is possible to confirm accidental ingestion, and it is possible to perform an immediate medical treatment at the time of accidental ingestion.

  In addition, since the IC tag 3 is not exposed on the surface of the tablet 1, the body of the IC tag 3 and the coating layer 4 are damaged during the process after the tablet 1 is manufactured (for example, transport process, packaging process, etc.) Or the IC tag 3 itself can be removed from the tablet 1. As a result, it is possible to suppress problems that information cannot be read or safety at the time of taking is reduced.

  In addition, since the IC tag 3 is embedded in the vicinity of the center (center of gravity) of the tablet 1, it is possible to suppress the deterioration of the weight balance with respect to the case where the IC tag 3 is not embedded. For this reason, generation | occurrence | production of the malfunction resulting from the bad weight balance in processes, such as conveyance of a tablet 1, packaging, can be suppressed.

  In addition, the PTP packaging machine 10 is provided with an information inspection device 22 that reads information on the IC tag 3 in the tablet 1 and individually inspects the tablet 1. For this reason, even if the appearance is similar or the same tablet that is difficult to determine in the appearance inspection, it can be reliably distinguished based on whether or not the read information is correct. It is possible to detect mixing of different varieties by determining items that can identify the varieties of the tablet 1, for example, product name, product identification code, or content / titer.

  Furthermore, an information inspection device 22 is provided on the downstream side of the sealing means 18. For this reason, after the tablet 1 is filled in the pocket portion 6 of the packaging film 7, the information of the tablet 1 is read. Therefore, the tablets 1 are arranged in an orderly manner, and it is easy to read information by the reading means 32 and to associate the read information with the tablets 1. In addition, it is possible to suppress problems such as the tablets not being filled despite the inspection, or the tablets not being inspected being erroneously filled. In addition, the cover film 8 is adhered to the packaging film 7, and after the information inspection, the tablet 1 pops out and becomes a missing tablet, or the tablet 1 determined to be a genuine product is replaced with a wrong product such as a different product. It is possible to suppress problems such as trapping.

  In addition, the reading means 32 reads information from the packaging film 7 side. When reading from the cover film 8 side, a magnetic field, electromagnetic waves, etc. are interrupted by the influence of the metal foil (aluminum foil), so that the reading sensitivity may be lowered or the reading may not be performed. In this regard, in this embodiment, information can be read with relatively high sensitivity.

  At the same time, when reading information, the shield 37 surrounds each reading head 35 and the tablet 1 corresponding to the reading head 35. For this reason, the malfunction that the information of the adjacent tablet 1 is read accidentally can be suppressed. As a result, since the individual tablets 1 can be reliably distinguished, more precise management or the like can be performed.

  An information inspection device 22 is disposed at a position where the PTP film 21 is intermittently transferred. For this reason, the information reading time can be sufficiently secured and the information can be read more reliably than when the information inspection device 22 is arranged at the position where the PTP film 21 is continuously transferred.

  In the embodiment described above, for example, a part of the configuration can be appropriately changed as follows. Of course, other modifications not exemplified below are also possible.

  (A) The integrated circuit of the IC tag 3 may be provided with a fluctuation information circuit capable of writing information after the IC tag 3 is manufactured. As a result, even after the tablet 1 is manufactured, information can be written in a non-contact manner using electromagnetic waves and the like, and fluctuation information associated with the manufacture of the tablet 1 and the PTP sheet 5 such as a manufacturing number, a use time limit, and an inspection result. Etc. can be stored in the tablet 1. Accordingly, a writing means for writing information may be provided in the PTP packaging machine 10. For example, the information inspection apparatus 22 may be provided with writing means. Specifically, a write head constituting a writing unit is provided adjacent to the read head 35 and information to be written is stored in the information storage unit 38. Then, the base 36 may be brought close to the PTP film 21 to read the information and simultaneously write the information. Thereby, it is possible to suppress problems such as information stored in advance in the IC tag 3 being different from the original information of the tablet 1. At this time, post-processing for abnormalities relating to packaging can be easily performed by writing information relating to packaging, for example, information such as packaging lines and packaging dates.

  (B) In the above-described embodiment, the base 36 moves toward and away. As shown in FIG. 5, the base 36 is fixed, and the shield 44 in the transfer direction of the PTP film 21 is placed in the pocket portion. It may be configured to be deformable following the movement of 6 or to be able to fall down. In this case, the PTP film 21 is not intermittent and may be continuously transferred.

  (C) Further, instead of moving the base 36 toward and away from the base 36, the PTP film 21 may be moved toward and away from the base 36.

  (D) In the above embodiment, the material of the shield 37 in the information inspection apparatus 22 is not particularly mentioned, but any material that can block the electromagnetic wave transmitted by the IC tag 3 between adjacent tablets 1 may be used. Metal, conductive rubber or the like may be applied.

  (E) The information inspection device 22 in the PTP packaging machine 10 may be installed after the pocket portion 6 is filled. For example, the position D or the sheet on the downstream side of the slit forming device 24 as shown in FIG. You may install in the place where the PTP film 21 like the position E etc. of the upstream of the punching apparatus 26 is intermittently transferred. Further, a position A that is the opening side of the pocket portion 6 on the downstream side of the filling device 16, a position B that is the opposite side of the packaging film 7 with respect to the position A, that is, a protruding side of the pocket portion 6, and sealing means 18. The packaging film 7 and the PTP film 21 such as the position C on the packaging film 7 side on the downstream side may be disposed at a position where the film is continuously transferred.

  (F) Although the information inspection apparatus 22 inspects the tablets 1 individually, a plurality of tablets 1 may be inspected collectively in units of 5 PTP sheets to be punched.

It is a block diagram which shows the whole structure of the PTP packaging machine in one Embodiment. It is sectional drawing which shows the structure of the tablet in one Embodiment. (A) is a PTP sheet, (b) is a partial enlarged sectional view showing a PTP sheet. It is a fragmentary sectional view which shows the structure of an information inspection apparatus, (a) is a figure which shows the cross section of the packaging film width direction, (b) is a figure which shows the cross section of the packaging film conveyance direction. It is a fragmentary sectional view which shows the information inspection apparatus of another form. It is a block diagram which shows the whole blister packaging machine for demonstrating the case where the arrangement | positioning positions of an information inspection apparatus differ.

DESCRIPTION OF SYMBOLS 1 ... Tablet, 3 ... IC tag, 4 ... Coating, 5 ... PTP sheet as a blister sheet, 6 ... Pocket part, 7 ... Packaging film, 8 ... Cover film, 10 ... PTP packaging machine as a blister packaging machine, 16 DESCRIPTION OF SYMBOLS ... Filling device, 18 ... Sealing means, 22 ... Information inspection apparatus as pharmaceutical solid preparation inspection apparatus, 21 ... PTP film as blister film, 32 ... Reading means, 33 ... Information processing means, 37 ... Shield, 39 ... Correct / incorrect Department.

Claims (12)

A blister packaging machine for packaging a pharmaceutical solid preparation in which IC tags each storing predetermined information are individually embedded into a blister sheet,
Reading means for reading the information stored in the IC tag of the pharmaceutical solid preparation ;
A pharmaceutical solid preparation testing device having an information processing means for processing the read information,
The IC tag stores at least information capable of specifying the type of pharmaceutical solid preparation ,
The blister packaging machine, wherein the information processing means includes a correct / incorrect determination unit that determines whether or not the solid pharmaceutical preparation whose information has been read is a different product based on the read information. The blister packaging machine according to claim 1, wherein the reading unit is capable of reading the information stored in the IC tag for each individual pharmaceutical solid preparation . The blister packaging machine according to claim 2, wherein the reading means includes a shield for blocking reading of information corresponding to adjacent pharmaceutical solid preparations . A filling device for filling the pharmaceutical solid preparation in the pocket portion of the packaging film;
The blister packaging machine according to any one of claims 1 to 3, wherein the reading means reads information on the solid pharmaceutical preparation at least after filling by the filling device. The belt-shaped packaging film and the cover film to be attached to the packaging film are transported and configured to produce a blister sheet,
While installing the pharmaceutical solid preparation inspection device in the section for intermittent transfer of the band-like blister film after the packaging film or the cover film is attached,
The blister packaging machine according to claim 4, wherein the reading means reads information on the pharmaceutical solid preparation at least when the transfer of the film is stopped. Provided with sealing means for attaching the cover film to the packaging film,
The blister packaging machine according to any one of claims 1 to 5, wherein the reading means reads information from the packaging film side at least after the cover film is attached by the sealing means. The IC tag can write information after its manufacture,
The blister packaging machine according to any one of claims 1 to 6, wherein the solid pharmaceutical preparation inspection device has a writing means for writing predetermined information to the IC tag.   The blister packaging machine according to claim 7, wherein the writing means writes information relating to packaging. A pharmaceutical solid preparation in which an IC tag storing information capable of identifying at least its own variety is embedded. The pharmaceutical solid preparation according to claim 9, wherein the IC tag is coated with a coating for preventing erosion by digestive fluid. The pharmaceutical solid preparation according to claim 9 or 10, wherein the IC tag is embedded without being exposed on the surface. The pharmaceutical solid preparation according to any one of claims 9 to 11, wherein the IC tag is embedded in the vicinity of the center of gravity.

Images