JP4644480B2 - Polyolefin resin multi-chamber bag - Google Patents

Description

  The present invention relates to a polyolefin resin-made multi-chamber bag, and more particularly to a polyolefin resin-made multi-chamber bag having a plurality of chambers separated by weak seal portions that can be easily peeled off during use.

  Resin bags and containers that are formed with weak seal parts that can be peeled manually between container walls or between container walls and other members, and used when used in the fields of food, pharmaceuticals, cosmetics, etc. Has been. For example, when multiple drugs are mixed and administered to a patient, such as when vitamins are mixed with physiological saline and injected or instilled into the patient, depending on the type of drug, the quality may deteriorate Therefore, there are multi-chamber infusion containers that can contain a plurality of drugs separately and mix them immediately before use, and many researches have been conducted on methods for forming such boundary portions.

As a method of forming a boundary part that can be easily peeled, as a technique related to a method of bonding a seal portion, for example, a seal edge having a specific shape is formed as a heat seal bar used when sealing the boundary part 2 A technique in which the peel strength at the boundary portion is set to an appropriate range by using a combination of bars and sandwiching the film after precisely controlling the positions of these seal edges (see, for example, Patent Document 1). Among the fusion parts of the multi-chamber infusion container formed of a thermoplastic resin film, the strong fusion part having the largest fusion strength is dispersed and distributed in the weak seal part, and the total occupied area of the weak seal part is A technique for making the area less than 25% (for example, see Patent Document 2) is disclosed.
In addition, as a technique related to the material of the seal portion, for example, a resin mixture composed of linear low density polyethylene and polypropylene, which are at least two types of polyolefin resins having different melting start temperatures, is used, and the inner wall surface of the container is used as the resin. By forming the mixture layer and heating the resin mixture layer to a temperature between the melting temperature of the linear low-density polyethylene and the melting temperature of the polypropylene to weld the inner wall surfaces of the container, (For example, refer to Patent Document 3), two different thermoplastic resins are streaked with a predetermined width in the axial direction of the resin tube on the inner surface of the resin tube of the inflation film made of thermoplastic resin. A method of forming a partially dissimilar resin tube having a streaked multilayer portion formed by lamination (see, for example, Patent Document 4), two or more kinds of densities are different. Syngeneic resin methods of using the weak seal portion made of a resin mixture layer obtained by mixing (e.g., see Patent Document 5.) And the like have been disclosed that.
However, in any case, the compatibility of the resins in the resin mixture is insufficient, the mixing ratio of the resin mixture is easily changed depending on the position, it is difficult to obtain a uniform resin layer, and the bonding strength of the weak seal portion is not uniform. It is easy to become. In addition, since resins having insufficient compatibility are mixed, there is a problem that the strength of the resin mixture layer is insufficient.
JP-A-8-24314 Japanese Patent Laid-Open No. 2004-476 JP-A-2-4671 JP 2000-14746 A JP 2003-40347 A

  In view of the above problems, the present invention has a polyolefin having a resin mixture layer having a sufficient strength, a uniform bonding strength, and a plurality of chambers separated by weak seal portions that can be easily peeled off. An object is to provide a multi-chamber bag made of a resin.

As a result of intensive studies to solve the above-mentioned problems, the present inventors have developed a laminated film using a resin mixture layer obtained by mixing a polyethylene resin and a modifier having a melting point lower than that of the polyethylene resin by 26 ° C. or more as a sealing layer. Use, when forming a multi-chamber bag having a plurality of chambers separated by a weak seal portion where the seal layers are weakly sealed, finds that the weak seal portion has a uniform bonding strength and can be easily opened, The present invention has been completed.

That is, according to the first aspect of the present invention, a polyolefin-based resin molded by heat-sealing the sealing layers of a polyolefin-based resin laminated film and having a plurality of chambers by providing a weakly sealable portion that can be easily peeled off. A resin multi-chamber bag, wherein the resin layer constituting the sealing layer of the laminated film is composed of a resin mixture layer obtained by mixing a polyethylene resin and a modifier, and the polyethylene resin is a linear low density polyethylene. And the modifier is selected from an ethylene-butene copolymer, an ethylene-propylene copolymer, a low melting point metallocene catalyst-based linear low density polyethylene, or a styrene / ethylene butylene / olefin crystal block copolymer. and wherein the melting point than the polyethylene resin is 26-60 ° C. low and amount of the mixture of the modifier is to 100 parts by weight of polyethylene resin And a polyolefin resin multi-chamber bag is provided, characterized in that 10 to 40 parts by weight.

  According to a second aspect of the present invention, there is provided a polyolefin-based resin multi-chamber bag according to the first aspect, wherein the laminated film comprises at least two layers of an outer layer and a seal layer.

  According to a third aspect of the present invention, there is provided a polyolefin-based resin multi-chamber bag according to the first or second aspect, wherein the laminated film comprises an outer layer, an intermediate layer and a seal layer. .

  According to the fourth invention of the present invention, in any one of the first to third inventions, the difference between the melting point of the resin constituting the outer layer of the laminated film and the average melting point of the resin mixture constituting the seal layer is 10 ° C. A polyolefin resin-made multi-chamber bag characterized by the above is provided.

  According to a fifth aspect of the present invention, there is provided a polyolefin-based resin multi-chamber bag according to any one of the first to fourth aspects, wherein the laminated film is an inflation co-extruded film. .

According to a sixth aspect of the present invention, there is provided a polyolefin-based resin multi-chamber bag according to any one of the first to fifth aspects, wherein the weak seal portion is formed at 105 to 115 ° C. Provided.

Moreover, according to the 7th invention of this invention, the medical multi-chamber bag which consists of the polyolefin resin-made multi-chamber bag of any one of the 1st- 6th invention is provided.

According to the present invention, in the polyolefin-based resin multi-chamber bag formed by heat-sealing the sealing layers of the polyolefin-based resin laminated film and having a plurality of chambers by providing a weak seal portion that can be easily peeled, The resin layer that constitutes the sealing layer of the polyolefin resin laminated film is a resin mixture layer in which a polyethylene resin and a modifier having a melting point lower than that of the polyethylene resin by 26 ° C. or more are mixed. In the weak seal portion, it is possible to obtain a multi-chamber bag made of polyolefin resin having uniform bonding strength and easy peelability.

  The polyolefin resin-made multi-chamber bag of the present invention has an outer layer, a seal layer, and, if necessary, a seal layer of a polyolefin resin laminate film composed of at least two layers having an intermediate layer. Polyolefin-based resin that can form a bag part by sealing and at the same time provide a weak seal part inside the bag part and divide it into a plurality of chambers, and peel off only the weak seal part when necessary to join the plurality of chambers. This is a multi-chamber bag. Details will be described below.

1. Polyolefin resin laminated film (1) Outer layer The outer layer of the polyolefin resin laminated film used in the present invention can be used without particular limitation as long as it is a polyolefin resin having transparency and flexibility. When the bag is used as a medical bag, it must be resistant to temperature conditions and impact such as heat sterilization, for example, high pressure steam sterilization or hot water sterilization, and the polyolefin resin having such characteristics As such, resins such as high density polyethylene, medium density polyethylene, low density polyethylene, linear low density polyethylene, and polypropylene are preferable.
The thickness of the outer layer is preferably 50 to 145 μm, more preferably 50 to 80 μm. Further, the outer layer is preferably in the range of 25 to 60%, preferably 20 to 45% of the total thickness of the laminated film. When it exceeds 60%, the entire bag becomes hard, and for example, when used as a medical bag, a uniform drainage flow rate cannot be obtained.

(2) Seal layer The seal layer of the polyolefin-based resin laminated film used in the present invention seals the outer peripheral portion of the entire bag with a strong seal of high heat fusion, and can be easily peeled off simultaneously with a weak seal of low heat fusion and It is a layer for forming a weak seal portion that can constitute a plurality of chambers. The seal layer is a resin mixture layer in which a polyethylene resin and a modifier having a melting point lower than that of the polyethylene resin by 26 ° C. or more are mixed.
The polyethylene resin constituting the resin mixture layer is linear low density polyethylene , and metallocene catalyst linear low density polyethylene is particularly preferable.
Examples of the modifier include a low-melting polyolefin resin having a melting point of 26 ° C. or more lower than that of the polyethylene resin, and a low-melting styrene block copolymer resin. Examples of the low melting point polyolefin-based resin include ethylene / α-olefin copolymers of ethylene and α-olefin copolymers such as propylene and butene-1 as comonomers. Among these, ethylene-butene Any one of a copolymer, an ethylene-propylene copolymer, and a low melting point metallocene catalyst linear low density polyethylene is used . As the styrene block copolymer resin, a styrene / ethylene butylene / olefin crystal block copolymer is used .

The difference between the melting points of the polyethylene resin and the modifier is required to be 26 ° C. or more, and preferably used in combination so as to be in the range of 26 to 60 ° C. For example, metallocene catalyst linear low density polyethylene (93 to 106 ° C.) / Ethylene-butene copolymer (65 ° C.), metallocene catalyst linear low density polyethylene (93 to 106 ° C.) / Ethylene-propylene copolymer They are used in combination such as coalescence (less than 50 ° C.).
When the melting point difference in the resin mixture is 26 ° C. or more, the strong seal (high temperature seal) causes the resin mixture to completely melt and increase the seal strength, and does not peel easily, and the weak seal (low temperature seal) A melted part and an unmelted part are present, and easy peelability is imparted. If the temperature difference between the melting points is too small, the conditions for forming a weak seal portion by welding in a peelable manner become narrow.
The melting point of the resin is a melting point measured by DSC.

The mixing ratio of the polyethylene resin and the modifier is 10 to 40 parts by weight, more preferably 10 to 25 parts by weight with respect to 100 parts by weight of the polyethylene resin. If the modifier is less than 10 parts by weight, it becomes difficult to form a peelable weak seal part, and if it exceeds 40 parts by weight, it is difficult to form a peelable weak seal part and the thermal deformation temperature is lowered. When used as a bag, the bag is deformed by autoclaving.
Moreover, the thickness of the sealing layer is preferably 10 to 50 μm, more preferably 25 to 35 μm. The sealing layer is preferably in the range of 15 to 38%, preferably 15 to 25% of the total thickness of the laminated film.

  In the laminated film used in the present invention, the difference between the melting point of the resin constituting the outer layer and the average melting point of the mixed resin constituting the seal layer is preferably 10 ° C. or more. When the difference between the melting point of the resin constituting the outer layer and the average melting point of the mixed resin constituting the seal layer is 10 ° C. or more, the stability of the obtained bag is increased.

(3) Intermediate layer The polyolefin-based laminated film used in the present invention may be provided with an intermediate layer as necessary. An intermediate | middle layer is used in order to provide the effect which gives a softness | flexibility and impact resistance to the whole film, without impairing transparency and a softness | flexibility. Therefore, the resin used for the intermediate layer is preferably an ethylene / α-olefin copolymer, and among them, linear low-density polyethylene, particularly preferably metallocene-based catalyst linear low-density polyethylene (mLLDPE) is preferably used. It is done. The thickness of the intermediate layer is preferably 30 to 100 μm, more preferably 65 to 95 μm. Moreover, 14-50% of the thickness of the whole laminated film is preferable, and, as for an intermediate | middle layer, More preferably, it is 40-50%.

(4) Production method of laminated film The polyolefin-based laminated film used in the present invention is produced by applying a known production method such as a water-cooled or air-cooled coextrusion inflation method, a coextrusion T-die method, or a lamination method. In particular, it is preferable to perform coextrusion molding by coextrusion method. In addition to improving the molding efficiency by forming a resin layer with a substantially uniform thickness, the characteristics of each layer are maintained because there is little deterioration of the resin during molding. Good transparency and flexibility can be obtained. The obtained laminated film may be a tube shape or a sheet shape. The temperature conditions in manufacture are 160-250 degreeC, More preferably, it is 165-230 degreeC. Since each layer is an ethylene-based resin and contains a resin that is excellent in meltability by heat, it is easy to weld each layer in forming a laminated film and hardly cause delamination. It is desirable to reduce the difference in the melt flow rate (MFR) of the resin used for the resin constituting each layer in order to maintain a substantially uniform layer thickness and moldability. Furthermore, the laminated film used in the present invention may be coextruded by dividing one layer into two or more layers, whereby the transparency of the entire film can be further improved.

2. Multi-chamber bag The multi-chamber bag made of polyolefin resin of the present invention is formed from the above-mentioned polyolefin laminated film. It is obtained by laminating the sealing layers of the laminated film and fusing with heat at the outer periphery to form a bag portion, and at the same time providing a weak seal portion inside the bag portion and dividing it into a plurality of chambers. An example of a multi-chamber bag will be described with reference to the drawings. In FIG. 1, the multi-chamber bag 1 is formed by laminating the sealing layers of laminated films on the inner surface, and providing the mixed injection port 4 and the discharge port 5 so that the outer peripheral portions 11 and 12 are strongly sealed with a heat seal bar. And a weak seal portion 13 is provided with a heat seal bar, and the bag is divided into the chamber 2 and the chamber 3 and divided into two chambers. Each of the chamber 2 and the chamber 3 stores a chemical solution or the like mixed at the time of use. The bag containing the contents is subjected to high-pressure steam sterilization or the like as necessary, and the external seal is applied to the contents stored in one chamber at the time of use, whereby the weak seal portion 13 is peeled off. 2 and the chemical solution accommodated in the chamber 3 are used so as to be mixed instantaneously.
In addition, the width | variety, number, position, etc. of a weak seal part are not restrict | limited in particular, It can change suitably with the contents. Moreover, when a tube-shaped film is used as the laminated film, it may not be necessary to provide 12 strong seal portions.
Here, although the temperature of the heat seal bar for forming the strong seal portion depends on the resin used, it is preferably 125 to 145 ° C, and the temperature of the heat seal bar for forming the weak seal portion is preferably 105 to 115 ° C. . By heat-sealing under such temperature conditions, the weakly sealed portion of the multi-chamber bag from the laminated film has a peel strength of 5N to 20N and can be easily peeled off only when necessary, and the contents can be instantly removed. It can be used by mixing.

  Further, the multi-chamber bag of the present invention can give excellent transparency and flexibility to the entire film due to transparency and flexibility possessed by each layer, and excellent impact resistance from the intermediate layer and the outer layer, and High pressure steam sterilization resistance and excellent easy peelability from the seal layer can be obtained, respectively, and the polyolefin resin multilayer film used in the present invention is blended simultaneously in separate chambers partitioned by a weak seal. It can be used as a medical multi-chamber bag that can store a drug that causes a change with time and can be mixed or dissolved at the time of use.

  The material to be enclosed in the multi-chamber bag of the present invention is not particularly limited. For example, the drug may be any of a powder, a liquid, or a solid. Examples of the powder include an antibiotic, an anticancer agent, a steroid, and a thrombus. Examples include hygroscopic, oxidative and heat-denaturing substances such as solubilizers and vitamins. Examples of liquids include physiological saline, glucose solution, distilled water for injection, electrolyte solution, amino acid solution, and fat emulsion. Is mentioned.

  In addition, when storing and storing antibiotics in the multi-chamber bag, low molecular weight substances (70 or less carbon atoms, especially 22 to 28 carbon atoms) contained in the raw material resin of the laminated film used in the present invention are antibiotics. There is a risk of binding to form insoluble fine particles. Therefore, it is preferable to take measures by heating the raw material resin in advance under reduced pressure, removing low molecular weight substances by maintaining the reduced pressure during film molding, or extracting or washing with n-hexane or hot water. .

Examples of the present invention will be described below to specifically explain the present invention. Seal conditions and seal strength were measured and evaluated as follows.
(1) Sealing conditions (i) Examples 1-5, comparative example 1: heater width 8 mm, seal length 15 mm, time 1.5 seconds (ii) Examples 6-9, comparative example 2: seal head length 120 mm, seal Width 18 mm, test piece 15 mm width, press pressure 0.4 MPa, time 2.4 seconds (2) Seal strength: The seal portion was cut out, and the peel strength of the strong seal portion was measured with a tensile tester. The weak seal part was subjected to a manual peel test. Each evaluation standard is as follows.
(I) Strong seal part (peel strength by tensile tester)
2: Peel strength is 20N
3: Peel strength is 21-30N
4: Peel strength is 31-35N
5: Breaking 36-40N
(Ii) Weak seal (peeling test by hand: peel strength)
1: Not bonded (~ 5N)
2: Peeling weak (6-9N)
3: Easy peeling state (10-15N)
4: Peeling but tight (16-20N)
5: Complete fusion (more than 21N)

Example 1
Using a water-cooled coextrusion inflation molding machine, high-density polyethylene (HDPE: Nippon Polychem HY540, melting point 135 ° C.) as an outer layer, metallocene catalyst-based linear low-density polyethylene (mLLDPE: Kernel KF271, Nippon Polychem) as an intermediate layer, Melting point: 102 ° C.) 100 parts by weight of metallocene catalyst linear low density polyethylene (mLLDPE: Kernel KF271, melting point: 102 ° C., Nippon Polychem Co., Ltd.) and ethylene-butene copolymer (EBM: JSR, melting point: 65) (Less than ° C.) Using a mixture of 20 parts by weight, a laminated film having an outer layer of 140 μm, an intermediate layer of 75 μm, and a seal layer of 75 μm was obtained. The sealing layers of the laminated film were overlapped to perform strong sealing and weak sealing to produce a multi-chamber bag as shown in FIG. Each seal part of the obtained bag was cut out, and a tensile tester (strong seal part) and a peel test (weak seal part) by hand were performed. The results are shown in Table 1.

(Example 2)
A multi-chamber bag was produced in the same manner as in Example 1 except that the composition of the metallocene catalyst-based linear low-density polyethylene and EBM in the seal layer was 100 parts by weight: 40 parts by weight, and the seal strength was measured. The results are shown in Table 1.

(Example 3)
A multi-chamber bag was produced in the same manner as in Example 6 except that the composition of the metallocene catalyst-based linear low-density polyethylene and EBM in the seal layer was 100 parts by weight: 10 parts by weight, and the seal strength was measured. The results are shown in Table 1.

Example 4
As a seal layer, 100 parts by weight of a metallocene catalyst-based linear low density polyethylene (mLLDPE: Kernel KF271 manufactured by Nippon Polychem, melting point 102 ° C.) and ethylene-propylene copolymer rubber (EPR: Tafmer P manufactured by Mitsui Chemicals, melting point 50) A multi-chamber bag was produced in the same manner as in Example 1 except that a mixture composed of 20 parts by weight was used, and the seal strength was measured. The results are shown in Table 1.

(Example 5)
A multi-chamber bag was produced in the same manner as in Example 4 except that the composition of the metallocene catalyst-based linear low-density polyethylene and Tuffmer P in the seal layer was 100 parts by weight: 40 parts by weight, and the seal strength was measured. The results are shown in Table 1.

(Comparative Example 1)
A multi-chamber bag was produced in the same manner as in Example 1 except that a low melting point resin was not used as the seal layer, and the seal strength was measured. The results are shown in Table 1.

(Example 6)
Linear low density polyethylene (LLDPE: Idemitsu Kosan MORETECH 0278, melting point 128 ° C.) as the outer layer, metallocene catalyst linear low density polyethylene (mLLDPE: Kernel KF283, Nippon Polyethylene Co.) as the intermediate layer, and direct seal layer From 90% by weight of linear low density polyethylene (LLDPE: Moretec 0278 manufactured by Idemitsu Kosan Co., Ltd., melting point 128 ° C.) and 10% by weight of styrene / ethylene butylene / olefin crystal block copolymer (SEBC: DYNARON 4600P manufactured by JSR, melting point 85 ° C.) A laminated film having an outer layer of 70 μm, an intermediate layer of 150 μm, and a seal layer of 80 μm was obtained. A multi-chamber bag was produced from this laminated film in the same manner as in Example 1, and the sealing strength was measured. The results are shown in Table 2.

(Example 7)
95% by weight of linear low-density polyethylene (LLDPE: Idemitsu Kosan Co., Ltd., Moertech 0278, melting point 128 ° C.) and a styrene / ethylene butylene / olefin crystal block copolymer (SEBC: JNARON DYNARON 4600P, melting point 85 ° C.) as the sealing layer A multi-chamber bag was produced in the same manner as in Example 9 except that a mixture consisting of 5% by weight was used, and the seal strength was measured. The results are shown in Table 2.

(Comparative Example 2)
A multi-chamber bag was manufactured in the same manner as in Example 9 except that a low melting point resin was not used as the seal layer, and the seal strength was measured. The results are shown in Table 2.

(Example 8)
Linear low density polyethylene (LLDPE: Idemitsu Kosan MORETECH 0278, melting point 128 ° C.) as the outer layer, metallocene catalyst linear low density polyethylene (mLLDPE: Kernel KF283, Nippon Polyethylene Co.) as the intermediate layer, and direct seal layer From 90% by weight of linear low-density polyethylene (LLDPE: Moiretec 0278 manufactured by Idemitsu Kosan Co., Ltd., melting point 128 ° C.) and 10% by weight of metallocene catalyst-based linear low density polyethylene (mLLDPE: Kernel KF271, melting point 102 ° C. by Nippon Polyethylene) A laminated film having an outer layer of 70 μm, an intermediate layer of 150 μm, and a seal layer of 80 μm was obtained. A multi-chamber bag was produced from this laminated film in the same manner as in Example 1, and the sealing strength was measured. The results are shown in Table 2.

Example 9
80% by weight of linear low density polyethylene (LLDPE: Idemitsu Kosan MORETECH 0278, melting point 128 ° C.) as a sealing layer and metallocene catalyst linear low density polyethylene (mLLDPE: Kernel KF271, Nippon Polyethylene, melting point 102 ° C.) A multi-chamber bag was produced in the same manner as in Example 11 except that a mixture consisting of 20% by weight was used, and the seal strength was measured. The results are shown in Table 2.

As is clear from Table 1, when a mixture layer of a polyethylene resin and a polyethylene resin having a melting point different by 26 ° C. or more is used as the seal layer resin, a strong seal with a seal temperature of 125 ° C. is completely fused. It can be seen that an easily peelable weak seal portion can be easily formed with a weak seal having a temperature of 95 to 110 ° C. (Examples 1 to 5 ). On the other hand, when a resin having a different melting point is not mixed with the seal layer resin, a weak seal portion cannot be formed even if the seal temperature is lowered by 10 ° C. (Comparative Example 1). As is clear from Table 2, when a mixture layer of a polyethylene-based resin and a modifier of a styrene-based block copolymer having a melting point different by 26 ° C. or more is used, an easily peelable weak seal portion can be easily formed. (Examples 6 and 7). On the other hand, when a resin having a different melting point is not mixed with the seal layer resin, a weak seal portion cannot be formed even if the seal temperature is lowered by 10 ° C. (Comparative Example 2). Further, when a mixture layer of a polyethylene-based resin and a metallocene catalyst-based linear low density polyethylene modifier having a melting point different by 26 ° C. or more is used, the temperature range for obtaining a weak seal portion can be set as wide as 3 ° C. (Examples) 8, 9).

  The polyolefin-based resin multi-chamber bag of the present invention has sufficient adhesive strength at the strong seal portion and uniform bonding strength and easy peelability at the weak seal portion, so that it causes a chemical change when blended at the same time. Such a medicine can be stored and used as a medical multi-chamber bag or the like that can be mixed or dissolved at the time of use.

It is a figure which shows an example of the multi-chamber bag made from polyolefin resin of this invention.

Explanation of symbols

1 Double-chamber bag 2, 3 rooms 4 Mixed injection port 5 Discharge port 11, 12 Strong seal part 13 Weak seal part

Claims (7)

A polyolefin-based resin multi-chamber bag formed by heat-sealing the sealing layers of a polyolefin-based resin laminated film and having a plurality of chambers with a weak seal portion that can be easily peeled,
The resin layer constituting the sealing layer of the laminated film is composed of a resin mixture layer obtained by mixing a polyethylene resin and a modifier , the polyethylene resin is a linear low density polyethylene, and the modifier is ethylene. -Selected from butene copolymer, ethylene-propylene copolymer, low melting point metallocene catalyst-based linear low density polyethylene, or styrene / ethylene butylene / olefin crystal block copolymer, and having a melting point higher than that of the polyethylene resin. A polyolefin-based resin multi-chamber bag having a temperature of 26 to 60 ° C. and a mixing amount of the modifier is 10 to 40 parts by weight with respect to 100 parts by weight of the polyethylene resin .   The multi-chamber bag made of polyolefin resin according to claim 1, wherein the laminated film comprises at least two layers of an outer layer and a seal layer.   The multi-chamber bag made of polyolefin resin according to claim 1 or 2, wherein the laminated film comprises an outer layer, an intermediate layer, and a seal layer.   The polyolefin resin according to any one of claims 1 to 3, wherein the difference between the melting point of the resin constituting the outer layer of the laminated film and the average melting point of the resin mixture constituting the sealing layer is 10 ° C or more. Made of multi-chamber bags.   The multi-chamber bag made of polyolefin resin according to any one of claims 1 to 4, wherein the laminated film is an inflation co-extruded film. The multi-chamber bag made of polyolefin resin according to any one of claims 1 to 5 , wherein the weak seal portion is formed at 105 to 115 ° C. A medical multi-chamber bag comprising the polyolefin resin multi-chamber bag according to any one of claims 1 to 6 .

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