JP4533185B2 - Solid lipid particle formulation - Google Patents

Description

  The present invention relates to a solid lipid particle emulsion that is easy to produce and highly stable. More specifically, triglyceride and / or wax ester that is solid or pasty at room temperature as component (A) and carbon as component (B). It is obtained by dispersing an oil phase composed of a lipid component containing a hydrogenated phospholipid having a phosphatidylcholine content of 60% by mass or more as a component (C) with a linear and saturated higher alcohol of several 12 or more in an aqueous phase. To a solid lipid particle emulsion.

  Conventionally, emulsions in which one of liquid phases that do not dissolve each other, such as water and oil, is dispersed as fine droplets in the other have been used in a wide range of fields such as pharmaceuticals, quasi drugs, cosmetics, and foods. Usually, an emulsion is an oil-in-water (O / W) emulsion, a water-in-oil (W / O) emulsion, or an O / W / O emulsion that is a combination of these depending on the liquid phase of the dispersed phase and the continuous phase. And W / O / W emulsions, etc., have been used depending on the application. In these emulsions, both the aqueous phase and the oil phase were in a liquid state.

  In recent years, in addition to the above, an oil phase is in a solid state, and studies on lipid particle emulsions in which the oil phase is dispersed in an aqueous phase have been underway. Such lipid particle emulsions are used as DDS preparations for the purpose of controlling the absorbability of drugs in the pharmaceutical field and cosmetic field, and in the food field, the stabilization of unstable substances and the masking effect of bitter components, etc. (See Patent Document 1, Non-Patent Documents 1, 2, and 3). In these, production of a lipid particle emulsion by an emulsification method using a special apparatus such as a high-pressure homogenizer, a microchannel, or a membrane is disclosed.

  However, the above technique requires expensive and special equipment and is insufficient for application in a wide range of fields. In addition, phospholipids having unsaturation disclosed in the interface formation of lipid particles are chemically unstable, and even in the case of saturated phospholipids, the phase transition temperature is around 50 ° C. Above this phase transition temperature, there are problems such as destabilization of lipid particles.

Special Table 2002-544155 Mitsutoshi Nakajima, Food and Food Ingredients Journal of Japan, 2004, 209, 11, p. 923 Wissing SA, Journal of Cosmetics Science, 2001, 52, p. 313 Bunjes H, Journal of Pharmaceutical Sciences, 2003, 92, 7, p. 1509

  In the above circumstances, there has been a demand for a solid lipid particle emulsion that can be easily produced without using a special apparatus and that has high stability. That is, an object of the present invention is to provide a solid lipid particle emulsion that can be easily produced and has excellent stability.

As a result of diligent research in view of the above circumstances, the present inventors have used a specific phospholipid and a higher alcohol in combination, so that these aggregates have a phase transition temperature of several degrees C. to about 30 ° C. compared to the case where each of them is alone. Also found to rise. When the lipid component obtained by adding triglyceride or wax ester to these phospholipids and higher alcohol is used as an oil phase and mixed with stirring in the aqueous phase, the phospholipid and higher alcohol form an interface, and triglyceride or wax ester is used as the core substance. Thus, the present inventors have found that a solid lipid particle emulsion having excellent stability can be easily formed and completed the present invention.

That is, the first invention of the present application lies in a solid lipid particle emulsion obtained by dispersing an oil phase comprising the following lipid components (A) to (C) in an aqueous phase.
(A) One or more selected from triglycerides and / or wax esters that are solid or pasty at room temperature.
(B) One or more selected from linear and saturated higher alcohols having 12 or more carbon atoms.
(C) 1 or more types chosen from hydrogenated phospholipid whose phosphatidylcholine content is 60 mass% or more.

  In the second invention of this application, the mass ratio (B) / (C) of the component (B) to the component (C) is in the range of 1/3 to 50/1, and the component (B) and the component (C) The solid lipid particle emulsion is characterized in that the mass ratio [(B) + (C)] / (A) of the total amount and the component (A) is in the range of 1/10 to 3/1.

  According to a third invention of the present application, the solid phase further contains at least one selected from the group consisting of glycerin, dipropylene glycol, 1,3-butylene glycol and polyethylene glycol. In particle emulsion.

  A fourth invention of the present application is the solid lipid particle emulsion described above, wherein the aqueous phase further contains at least one selected from water-soluble polymers.

  5th invention of this application exists in the solid lipid particle obtained by removing an aqueous phase from said solid lipid particle emulsion.

  6th invention of this application exists in said solid lipid particle emulsion or solid lipid particle characterized by being the external preparation for skin or hair.

  7th invention of this application exists in the composition for external use for skin or hair characterized by mix | blending said solid lipid emulsion or solid lipid particle.

  Component (A) is a triglyceride and / or waxtel that is solid or pasty at room temperature, Component (B) is a linear and saturated higher alcohol having 12 or more carbon atoms, Component (C) has a phosphatidylcholine content of 60% or more. The solid lipid particle emulsion of the present invention, which is obtained by dispersing a lipid component composed of a hydrogenated phospholipid in a fluid liquid containing water, can be easily produced and preserves the solid lipid particles Excellent stability and excellent sensory characteristics when used as an external preparation.

The triglyceride used in the present invention is mainly composed of a fatty acid and a triester of glycerin, and those derived from natural animals and plants or obtained by chemical synthesis can be used. On the other hand, the wax ester is composed mainly of fatty acid and alcohol esters, and those derived from natural animals and plants or obtained by chemical synthesis or the like can be used. In the present invention, among the above-mentioned triglycerides and wax esters, those which are solid or pasty at room temperature are used as the component (A). These have a melting point in a temperature range exceeding room temperature (20 ° C.), and in particular, pastes can be distinguished from liquids in that they are not completely liquid at room temperature but are semi-solid.

  As a component (A) in this invention, the triglyceride or wax ester which satisfy | fills said requirements may be used individually, respectively, or 2 or more types may be mixed and used for it. Moreover, even if it is not solid or pasty alone, it can be used as a component corresponding to the present component (A) as long as it exhibits solid or pasty properties as a mixture when mixed with other things. .

  Specific examples of triglycerides include glyceryl trimyristate, glyceryl tripalmitate, glyceryl tristearate, glyceryl tribehenate, glyceryl tri (capryl, caprin, myristic, stearate), palm oil, coconut oil, beef tallow, cured An oil etc. can be mentioned. Examples of the wax ester include myristyl myristate, cetyl myristate, cetyl palmitate, cetyl stearate, beeswax, carnauba wax, candelilla wax, rice bran wax and the like.

  The higher alcohol used as the component (B) in the present invention is a linear and saturated higher alcohol having 12 or more carbon atoms, and can be derived from animals or plants or chemically synthesized. These higher alcohols can be used alone or in combination of two or more.

  Examples of the higher alcohol used in the present invention include dodecanol, tridecanol, tetradecanol, pentadecanol, hexadecanol, heptadecanol, octadecanol, nonadecanol, icosanol, heicosanol, docosanol, octacosanol, dotoriacontanol and the like. Can be mentioned.

  As the phospholipid of the component (C) of the present invention, a hydrogenated phospholipid having a phosphatidylcholine content of 60% by mass or more and using hydrogenation is used. Examples of phospholipid components other than phosphatidylcholine include phosphatidic acid, phosphatidylserine, phosphatidylethanolamine, phosphatidylinositol, and phosphatidylglycerol. Examples of the phospholipid used in the present invention include phospholipids derived from natural animals and plants, such as those obtained by hydrogenating egg yolk-derived or soybean-derived phospholipids. Moreover, what was chemically synthesized can also be used similarly.

As the composition ratio of each lipid component (A) to (C) constituting the solid lipid particle of the present invention, the mass ratio (B) / (C) of the component (B) to the component (C) is from 1/3 to 50. Is preferably in the range of 1/2, more preferably in the range of 1/2 to 20/1.
Further, the mass ratio [(B) + (C)] / (A) of the total amount of component (B) and component (C) to component (A) is preferably in the range of 1/10 to 3/1. More preferably, it is in the range of 1/2 to 35/1. Within these ranges, the preparation of the solid lipid particle emulsion is easier and the stability of the solid lipid particles is particularly excellent.

  The lipid components (A) to (C), which are the oil phase in the solid lipid particle emulsion of the present invention, can be used within a range that does not impair the effect of the present invention that a stable solid lipid particle emulsion can be easily produced. It is possible to mix various soluble components.

  The aqueous phase, which is a continuous phase in the solid lipid particle emulsion of the present invention, is a liquid phase consisting essentially of water. However, if necessary, the aqueous phase is in a range that does not affect the preparation of the solid lipid particle emulsion. It is possible to mix other soluble solvents and various water-soluble components.

  In the present invention, when the aqueous phase further contains at least one selected from the group consisting of glycerin, dipropylene glycol, 1,3-butylene glycol and polyethylene glycol, the stability of the emulsion and the functionality as a composition for external use. This is preferable because the characteristics are improved.

  In the present invention, it is preferable that the water phase further contains at least one water-soluble polymer selected from water-soluble polymers because the stability of the emulsion and the sensory characteristics as an external composition are improved.

  As the water-soluble polymer, natural water-soluble polymers, natural water-soluble polymer derivatives, synthetic water-soluble polymers and the like can be used alone or in admixture of two or more. Specifically, carrageenan, alginic acid, agar, guar gum, starch, pectin, soy protein, gelatin, albumin, casein, hyaluronic acid, xanthan gum, methylcellulose, ethylcellulose, hydroxypropylmethylcellulose, carboxyvinyl polymer, acrylic acid / alkyl methacrylate A polymer, polyacrylic acid amide, polyvinyl alcohol, polyvinyl pyrrolidone, etc. can be mentioned.

  In the solid lipid particle emulsion of the present invention, the lipid component that is the oil phase is heated and dissolved, and then the oil phase is added and dispersed while stirring the aqueous phase heated to the same temperature or higher, and then cooled. It can be manufactured by doing. It is not necessary to use a special apparatus for stirring the aqueous phase, and it can be produced by any known apparatus such as a magnetic stirrer or a homomixer as long as heating and stirring are possible. Moreover, it is also possible to produce using a special apparatus such as a high-pressure homogenizer, a microchannel, or a membrane, instead of simple stirring and dispersion.

  When the specific lipid component of the present invention is used, the detailed mechanism by which a solid lipid particle emulsion is easily and stably produced is unknown, but the phase transition temperature increases when a higher alcohol is combined with phospholipid. This is considered to be one of the reasons for enhancing the stability of the solid lipid particle interface.

  In the production of the solid lipid particle emulsion, when the content of the lipid component constituting the solid lipid particle is 30% by mass or less with respect to the entire solid lipid particle emulsion, the dispersion of the lipid component in the aqueous phase is easier. At the same time, it is preferable because it has excellent sensory characteristics when used with an external composition. If it exceeds 30% by mass, the efficiency of dispersion deteriorates, and depending on the stirring conditions, it may become impossible to disperse in some cases.

  The solid lipid particles of the present invention can be produced by removing the fluid liquid from the solid lipid particle emulsion obtained by the above method. Any known technique can be used to remove the fluid liquid. For example, centrifugation, membrane filtration, lyophilization and the like can be mentioned.

  The solid lipid particle emulsion or solid lipid particle according to the present invention can be applied to a body surface such as skin or hair as an external preparation and can impart unique sensory characteristics. In addition, the solid lipid particle emulsion or solid lipid particle of the present invention can be blended as a blending component in various external compositions for skin and hair, and can impart unique sensory characteristics to these external compositions. Is possible.

  In the external composition containing the solid lipid particle emulsion or the solid lipid particles according to the present invention, components that are usually added to cosmetics, quasi drugs, pharmaceuticals, foods and the like can be added as necessary. That is, as specific ingredients, physiological medicinal ingredients, fats and oils, dyes, fragrances, preservatives, surfactants, pigments, antioxidants, chelating agents, ultraviolet absorbers, ultraviolet scattering agents, inorganic salts, saccharides, salts, Vitamins, plant extracts and the like can be mentioned.

  EXAMPLES Hereinafter, although an Example and a comparative example are given and this invention is demonstrated in more detail, this invention is not necessarily limited to these Examples.

Example 1
5 g of cetyl palmitate, 1 g of hexadecanol, and 0.5 g of hydrogenated soybean phospholipid (phosphatidylcholine content of 90 mass% or more, hereinafter abbreviated as “PC90” or the like depending on the content) are uniformly heated and dissolved to obtain an oil phase. It was. Next, 93.5 g of purified water preheated to 80 ° C. was stirred at 400 rpm with a magnetic stirrer, and the oil phase was gradually added to emulsify. This emulsion was cooled to room temperature to obtain a solid lipid particle emulsion of the present invention. The obtained solid lipid particle emulsion was observed with a polarizing microscope, and it was confirmed that spherical and crystalline solid lipid particles having a particle diameter of about 100 to 500 μm were formed (FIG. 1). This solid lipid particle emulsion was stored at 40 ° C. for one month, and the stability of the solid lipid particles was confirmed by a polarizing microscope. Coherence was not recognized, and the crystal state was maintained and was stable.

(Differential scanning thermal analysis)
The solid lipid particle emulsion prepared in Example 1 was subjected to DSC (Differential Scanning Calorimetry) measurement, and the phase transition temperature was analyzed. Moreover, it analyzed as a comparison also about each lipid component used in Example 1, and the mixed lipid by 2 types chosen from them. The analysis was performed using a differential scanning calorimeter (DSC6200, manufactured by SII Nano Technology) under a temperature rising condition of 5 ° C./min. The solid lipid particle emulsion of Example 1 was used as an analysis sample as it was, but for the other lipid samples, 7 times the weight of water was added to the lipid component, and the temperature was once raised to the phase transition temperature or higher. The sample was quenched after being sufficiently hydrated and used as an analytical sample.

  The analysis results are shown in Table 1. The numbers in the table indicate the peak top temperature of the DSC curve, and for the two mixtures of lipids, the highest peak top temperature is measured among the various mixing ratios. In the case of each lipid component used alone in Example 1, the phase transition temperature was around 52 ° C. in all cases. On the other hand, in the system in which two kinds of lipids were mixed, a unique phenomenon was observed in which the phase transition temperature rose as close as 20 ° C. when hexadecanol and hydrogenated soybean phospholipid (PC90) were mixed.

(Table 1)
―――――――――――――――――――――――
Sample (℃)
―――――――――――――――――――――――
(a) Cetyl palmitate 52.2
(b) Hexadecanol 52.5
(c) Hydrogenated soybean phospholipid (PC90) 52.1
Mixed lipid of (a) and (b) 48.1
Mixed lipid of (a) and (c) 52.1
Mixed lipids of (b) and (c) 70.6
-----------------------
Solid lipid particles of Example 1 Peak 1 31.6
Peak 2 45.4
Peak 3 48.6
Peak 4 68.7
―――――――――――――――――――――――

  The DSC curve for the solid lipid particle emulsion of Example 1 is shown in FIG. As shown in the figure, four peaks from peak 1 to peak 4 were detected. As shown in Table 1, among these, the temperature of peak 4 almost coincides with the peak temperature of the mixed lipid system of hexadecanol and hydrogenated soybean phospholipid (PC90), and the temperature of peak 3 is cetyl palmitate and It almost coincided with the peak temperature of the mixed lipid system of hexadecanol. Judging from these results and physical properties such as polarities of the constituent components, in the solid lipid particles of Example 1, hexadecanol and hydrogenated soybean phospholipid (PC90) form an interface, and cetyl palmitate and excess hexadeca It is thought that it has a structure with a knoll as a core substance. That is, by using a composition composed of a specific proportion of the specific component disclosed in the present invention, a hydrated solid is formed at the interface at a higher temperature than in the case of each component alone, and it is easy to produce and has excellent thermal stability. It was suggested that a solid lipid emulsion was formed.

Example 2
After producing a solid lipid particle emulsion by the same composition and production method as in Example 1, water was filtered off and freeze-dried to obtain solid lipid particle powder of the present invention. The obtained solid lipid particles were observed with a polarizing microscope, and spherical and crystalline solid lipid particles having a particle diameter of about 100 to 500 μm were confirmed. This solid lipid particle powder was stored at 40 ° C. for one month as in Example 1, and its stability was confirmed with a polarizing microscope. The crystal state was maintained and was stable.

Example 3, Comparative Examples 1-3
The solid lipid particles of the present invention (Example 3) having the composition shown in Table 2 below and the solid particles of Comparative Examples 1 to 3 were produced in the same manner as in Example 1, and the same method as in Example 2. By removing water. Moreover, the production | generation of particle | grains was evaluated with the same 40 degreeC and 1 month storage conditions as Example 1 for the stability of the produced | generated solid lipid particle | grains with the polarization microscope. In addition, the compounding quantity in the composition in a table | surface is the mass%.

(Table 2)
―――――――――――――――――――――――――――――――――――――――
Examples Comparative Examples Comparative Examples Comparative Examples Ingredient names 3 1 2 3
―――――――――――――――――――――――――――――――――――――――
(1) Glyceryl tristearate 15.0-15.0 15.0
(2) Octadecanol 10.0 10.0-10.0
(3) Hydrogenated egg yolk phospholipids 2.0 2.0 2.0 −
(PC70)
(4) Purified water Residual Residue Residual Residue Residue --------------------------------
Generation of particles Spherical solid particles Not generated Amorphous particles Not generated Storage stability Stable − Coalescence and aggregation −
―――――――――――――――――――――――――――――――――――――――

  As shown in Table 2, the solid lipid particles of Example 3 formed spherical solid lipid particles and were excellent in storage stability. However, the compositions of Comparative Examples 1 and 3 that did not satisfy the requirements of the present invention did not produce spherical solid particles. In Comparative Example 2, although particles were generated, the particles were amorphous and inferior in stability.

Examples 4-7
The solid lipid particle emulsion of the present invention having the composition shown in Table 3 below was produced. The manufacturing method is
After the oil phase components are uniformly mixed and dissolved, they are added to the aqueous phase that has been premixed and heated to 80 ° C. with stirring. The mixture is emulsified with a homomixer at 5000 rpm and cooled to room temperature with stirring. I let you. In addition, the compounding quantity in the composition in a table | surface is the mass%.

(Table 3)
―――――――――――――――――――――――――――――――――――――――
Examples Examples Examples Examples Ingredient names 4 5 6 7
―――――――――――――――――――――――――――――――――――――――
(Oil phase component)
(1) Glyceryl tripalmitate 8.0 8.0 8.0 8.0
(2) Cetyl palmitate 2.0 2.0 2.0 2.0
(3) Cetyl alcohol (*) 1.0 1.0 1.0 1.0
(4) Hydrogenated soybean phospholipid 0.3 0.5 1.0 1.5
(PC90)
------------------------------------
(Aqueous phase component)
(5) Glycerin 5.0 5.0 5.0 5.0
(6) Phenoxyethanol 0.1 0.1 0.1 0.1
(7) Carboxyvinyl polymer 0.1 0.1 0.1 0.1
(8) Potassium hydroxide 0.03 0.03 0.03 0.03
(9) Purified water Residue Residue Residue Residue Residue ---------------
* Mixture with octadecanol, tetradecanol, etc. mainly composed of hexadecanol

  When the obtained solid lipid particle emulsion was evaluated by the same method as in Example 1, it was confirmed that spherical solid lipid particles having a particle diameter of about 20 to 100 μm were formed, and the storage stability was excellent. Further, no phenomenon such as creaming was observed, and the stability as a preparation was excellent.

  The solid lipid particle emulsion of the present invention having the composition shown in Table 4 below was produced. In the production method, the oil phase component is uniformly mixed and dissolved, then added to the aqueous phase component previously mixed and heated to 80 ° C. with stirring, emulsified at 5000 rpm with a homomixer, and stirred. And cooled to room temperature. In addition, the compounding quantity in the composition in a table | surface is the mass%.

(Table 4)
―――――――――――――――――――――――――――――――――――――――
Examples Examples Examples Examples Ingredients 8 9 10 11
―――――――――――――――――――――――――――――――――――――――
(Oil phase component)
(1) Glyceryl tripalmitate 8.0 8.0 8.0 8.0
(2) Cetyl palmitate 2.0 2.0 2.0 2.0
(3) Cetyl alcohol (*) 5.0 5.0 5.0 5.0
(4) Behenyl alcohol (**) -3.0 5.0 5.0
(5) Hydrogenated soybean phospholipid 1.0 1.0 1.0 1.0
(PC90)
------------------------------------
(Aqueous phase component)
(6) Glycerin 5.0 5.0 5.0 5.0
(7) Phenoxyethanol 0.1 0.1 0.1 0.1
(8) Carboxyvinyl polymer 0.1 0.1 0.1 0.1
(9) Potassium hydroxide 0.03 0.03 0.03 0.03
(10) Purified water Residue Residue Residue Residue Residue ---------------
* Mixture with octadecanol, tetradecanol, etc. mainly composed of hexadecanol
** Mixture with octadecanol, hexadecanol, etc. based on docosanol

  When the obtained solid lipid particle emulsion was evaluated by the same method as in Example 1, it was confirmed that spherical solid lipid particles having a particle diameter of about 20 to 100 μm were formed, and the storage stability was excellent. Further, no phenomenon such as creaming was observed, and the stability as a preparation was excellent.

Example 12
The solid lipid particle emulsion of the present invention having the composition shown in Table 5 below was produced. In the production method, the oil phase components are uniformly mixed and dissolved, and then added to the aqueous phase premixed and heated to 80 ° C. with stirring. The mixture is emulsified with a homomixer at 5000 rpm and stirred. And cooled to room temperature.

(Table 5)
――――――――――――――――――――――――
Ingredient name Mass%
――――――――――――――――――――――――
(Oil phase component)
(1) Tori (Capril Caprin 8.0
・ Myristine stearic acid glyceryl
(2) Beeslow 4.0
(3) Behenyl alcohol 6.0
(4) Stearyl alcohol 2.0
(5) Hydrogenated soybean phospholipid (PC90) 0.7
-----------------------
(Aqueous phase component)
(6) Dipropylene glycol 3.0
(7) 1,3-butylene glycol 3.0
(8) Sodium hyaluronate 0.1
(9) Acrylic acid / methacrylic acid 0.1
Alkyl copolymer
(10) Potassium hydroxide 0.02
(11) Methylparaben 0.1
(12) edetate trisodium 0.02
(13) Purified water residue ――――――――――――――――――――――――

  The obtained solid lipid particle emulsion was observed with a polarizing microscope, and formation of spherical solid lipid particles having a particle diameter of 20 to 50 μm was confirmed. The obtained solid lipid particle emulsion was stored at 40 ° C. for 1 month and confirmed for stability. As a result, no aggregation or coalescence was observed, and the stability was excellent. Moreover, when sensory evaluation was performed regarding the obtained composition, it was a composition for external use having good stretch and excellent moisturizing feeling.

  Since the solid lipid particle emulsion and the solid lipid particle of the present invention can be easily produced and have excellent stability, they can be applied to cosmetics, quasi drugs, pharmaceuticals, and foods.

It is a polarization micrograph for drawing substitutes which shows the form of the solid lipid particle emulsion of Example 1 which concerns on this invention. It is a figure which shows the DSC curve of the solid lipid particle emulsion of Example 1 which concerns on this invention.

Claims (6)

An oil phase composed of the lipid components (A) to (C) below is obtained by dispersing in an aqueous phase, and the mass ratio (B) / (C) of the component (B) to the component (C) is from 1/3. 50/1, and the mass ratio of the total amount of component (B) and component (C) to component (A) [(B) + (C)] / (A) is from 1/10 to 3/1. solid lipid particles the emulsion, characterized in range der Rukoto ((a) a phospholipid, (b) a nonionic surfactant, (c) a higher alcohol, (d) an oil, (e) a polyhydric alcohol and ( f) It contains water, the content of component (d) is 1 to 30% by mass, the component (d) contains 40% by mass or more of solid oil and / or paste oil, and component (a) And the total content of component (b) and the content ratio of component (d) is 2: 1 to 1:10 by mass ratio, and the particle size of the emulsified droplets is 1 μm or less. Except that an oil-in-water emulsified cosmetic.).
(A) One or more triglycerides that are solid or pasty at room temperature and one or more wax esters selected from myristyl myristate, cetyl myristate, cetyl palmitate, cetyl stearate, beeswax, carnauba wax, candelilla wax and rice bran wax .
(B) One or more selected from linear and saturated higher alcohols having 12 or more carbon atoms.
(C) 1 or more types chosen from hydrogenated phospholipid whose phosphatidylcholine content is 60 mass% or more. The solid lipid particle emulsion according to claim 1, wherein the aqueous phase further contains at least one selected from the group consisting of glycerin, dipropylene glycol and 1,3-butylene glycol. The solid lipid particle emulsion according to claim 1 or 2 , wherein the aqueous phase further contains at least one selected from water-soluble polymers. Solid lipid particles obtained by removing the aqueous phase from the solid lipid particle emulsion according to any one of claims 1 to 3 . The solid lipid particle emulsion according to any one of claims 1 to 3 or the solid lipid particles according to claim 4 , which is an external preparation for skin or hair. An external composition for skin or hair, comprising the solid lipid particle emulsion according to any one of claims 1 to 3 or the solid lipid particle according to claim 4 .