JP4480360B2 - Aerosol composition - Google Patents

Description

  An aerosol composition comprising a stock solution containing an aqueous component and an oily component, and a propellant mainly composed of a hydrocarbon having 3 to 5 carbon atoms, and a mixture (stock solution) of the oily component and the aqueous component and the aerosol composition Are both in a uniform state and do not separate even if left for a long time. In particular, the present invention relates to a stable aerosol composition that does not separate even when stored at a low temperature (5 ° C.) or a high temperature (45 ° C.).

  The conventional aerosol composition comprising an oily component, an aqueous component, and liquefied petroleum gas to form an emulsion is separated from the oily component and aqueous component containing the liquefied petroleum gas inside the aerosol container. The container was shaken, and the oily component and the aqueous component were mixed and sprayed. However, separation of the oily component and the aqueous component is very fast, and some of them are separated in the course of injection, and there are cases where injection cannot be performed with a uniform composition (for example, see Patent Document 1). Furthermore, since the liquefied petroleum gas acting as a propellant becomes a part of the oil component and is dissolved in the oil solvent, the oil component is refined by the liquefied petroleum gas when jetted, but the aqueous component is not refined, The sprayed particles (sprayed particles) are likely to vary, making them unsuitable for space products.

  (A) an insecticidal component, (b) a surfactant, (c) an aliphatic hydrocarbon containing 8 to 16 carbon atoms, and (d) water, and (e) liquefied petroleum gas as a propellant The aerosol composition which consists of is disclosed (for example, refer patent document 2). Patent Document 2 discloses fatty acid ester-based surfactants such as sorbitan monolaurate, sorbitan sesquioleate, polyoxyethylene laurate, and diglyceryl oleate as surfactants.

  A water-in-oil aerosol product containing an aqueous phase and an oil phase composed of an oil component and a propellant has been disclosed (see, for example, Patent Document 3). Patent Document 3 describes that by setting the surface tension of the aqueous phase to 70 dyne / cm or less, even in a water-in-oil aerosol product, the spray particles are fine and suitable for a space spray product. ing.

  Also, (a) an insecticidal component, (b) a surfactant, (c) an aliphatic hydrocarbon containing 8 to 16 carbon atoms, and (d) an aerosol stock solution containing water, and (e) liquefied as a propellant. A microemulsion aerosol composition composed of petroleum gas is disclosed (see, for example, Patent Document 4). Patent Document 4 describes that the microemulsion aerosol composition is one liquid.

  However, the emulsion type aerosol composition (product) of Patent Documents 2 to 4 may be easily separated depending on the temperature condition, and tends to be more easily separated when stored at low or high temperatures. There has been no stable emulsion type aerosol composition so far, which does not separate even when the ambient temperature changes.

JP 52-1031 A JP 2001-89303 A JP 2001-240851 A Japanese Patent Laid-Open No. 2003-40704

  An object of the present invention is to provide a stable aerosol composition that does not separate even when left at a low temperature (5 ° C.) or a high temperature (45 ° C.) for a long time.

  The present invention relates to a uniform aerosol composition comprising a uniform stock solution containing an aqueous component and an oily component, and a propellant mainly composed of a hydrocarbon having 3 to 5 carbon atoms.

  The stock solution preferably contains a surfactant having an HLB of 5 to 10 and a surfactant having an HLB of 15 to 19.

  It is preferable that the surfactant having an HLB of 5 to 10 is a fatty acid ester, and the surfactant having an HLB of 15 to 19 is a polyoxyethylene alkyl ether.

  The stock solution preferably does not have a flash point.

  When the stock solution containing the aqueous component and the oily component is uniform, it is not necessary to separately fill the aerosol container with the aqueous component and the oily component (two-stage filling), and the production is simplified. Since the aerosol composition is uniform, it can be sprayed with a uniform composition even when sprayed for a long time. Since the aerosol composition contains an aqueous component, the stock solution has no flash point and is highly safe against fire. Furthermore, even when the aerosol product is stored at a low temperature (5 ° C.) or at a high temperature (45 ° C.), the aerosol composition does not separate and is excellent in stability.

  The present invention relates to a uniform aerosol composition comprising a uniform stock solution containing an aqueous component and an oily component, and a propellant mainly composed of a hydrocarbon having 3 to 5 carbon atoms.

  Here, the uniform stock solution does not completely dissolve like a mixture of water and ethanol, but the oily component and the aqueous component form an emulsion, but after the stock solution is prepared, it is allowed to stand at 25 ° C. for one month. Even so, the undiluted solution has translucency and is not separated. The uniform aerosol composition means that the stock solution and the propellant mainly composed of hydrocarbons having 3 to 5 carbon atoms form an emulsion, but after preparing the aerosol composition, 5 ° C., 25 ° C. and Even when left at 45 ° C. for one month, the aerosol composition is translucent and does not separate.

  To have translucency means that the transmittance (τv) of the emulsion is 70 to 100% when the transmittance of water is 100%. The transmittance is preferably 80 to 100%. When the transmittance is less than 70%, it becomes easy to separate after standing for a long time.

  The transmittance (τv) represents the ratio (Φt / Φi, defined by JIS Z 8105) of the light beam Φt that passes through the object (stock solution or aerosol composition) and the light beam Φi that enters the object as a percentage. Value, that is, Y of the tristimulus value of the object color due to transmission in the XYZ color system (specified in JIS Z8701), and a standard color (pulse xenon) using a color difference meter (CT-210, manufactured by Minolta, Inc.) It is a value obtained based on the value measured in the lamp). The transmittance of the aerosol composition is a value measured using a transparent polyethylene terephthalate aerosol container filled with the aerosol composition.

  In the present invention, the stock solution containing the aqueous component and the oily component is uniform, and the stock solution and the aerosol composition comprising the propellant mainly containing a hydrocarbon having 3 to 5 carbon atoms are uniform. It is preferable to use a specific lipophilic surfactant and a specific hydrophilic surfactant described later in combination. The blending ratio of the lipophilic surfactant and the hydrophilic surfactant is preferably 5: 1 to 1: 1, more preferably 4: 1 to 2: 1. If the blending ratio is outside the range of 5: 1 to 1: 1, the stock solution and the aerosol composition tend to be difficult to be uniform.

  When oily components are injected into the atmosphere, they are refined by vaporization of propellants mainly composed of hydrocarbons having 3 to 5 carbon atoms, diffuse in the space, adhere to the injection target, and provide effective components. To do.

  The content of the oil component is preferably 50 to 90% by weight, more preferably 60 to 85% by weight in the stock solution. If it is less than 50% by weight, the stock solution and the aerosol composition tend to be difficult to be uniform. When it exceeds 90% by weight, the stock solution tends to have a flash point, and the safety against fire tends to be lowered.

  The oily component can be obtained by blending a lipophilic surfactant, an oil-soluble active ingredient, or the like with an oily solvent that is liquid at room temperature.

  Examples of oily solvents that are liquid at room temperature include liquid hydrocarbons such as kerosene, squalane, squalene, liquid paraffin, and isoparaffin, isopropyl myristate, cetyl isooctanoate, octyldodecyl myristate, isopropyl palmitate, diethyl phthalate, and phthalic acid Ester oil such as diethoxyethyl and diethoxyethyl succinate, silicone oil such as methylpolysiloxane, decamethyltetrasiloxane, octamethylcyclotetrasiloxane, and methylphenylpolysiloxane, camellia oil, corn oil, olive oil, castor oil, sacrificial oil Examples thereof include fats and oils such as flower oil, jojoba oil and coconut oil, higher fatty acids such as oleic acid, higher alcohols such as oleyl alcohol and isostearyl alcohol. It should be noted that oily components that are solid at room temperature, such as higher fatty acids such as stearic acid and palmitic acid, higher alcohols such as cetanol, waxes such as beeswax and paraffin wax, are dissolved in the oily solvent that is liquid at room temperature. May be used. In particular, when mixed with an aqueous component to form a stock solution, and when an aerosol composition containing a propellant mainly containing a hydrocarbon having 3 to 5 carbon atoms, it tends to be uniform, and at high and low temperatures. However, liquid hydrocarbons are particularly preferred in that stable ones can be easily obtained without separation. Further, in order for the stock solution to have no flash point, it is preferable to use an oily solvent having a flash point of 60 ° C. or higher, preferably 70 ° C. or higher, more preferably 80 ° C. or higher.

  The oily solvent that is liquid at room temperature is preferably 40 to 80% by weight, more preferably 50 to 75% by weight in the stock solution. When it is less than 40% by weight, the stock solution and the aerosol composition tend to be difficult to be uniform. If it exceeds 80% by weight, the blending amount of the aqueous component decreases, and the stock solution tends to have a flash point, and the safety against fire tends to be lowered.

  The lipophilic surfactant is uniform when an oily component is mixed with an aqueous component to make a stock solution, and when a propellant mainly containing a hydrocarbon having 3 to 5 carbon atoms is blended to make an aerosol composition. In order to maintain the uniform state of the stock solution without separating the oily component and the aqueous component even when stored at high and low temperatures, the aerosol composition is further used to maintain the uniform state. .

  Examples of the lipophilic surfactant include 5 to 10, preferably 5 to 9 HLB such as glycerin fatty acid ester, poly (di-tri-tetra-hexa-penta-deca, etc.) glycerin fatty acid ester, sorbitan fatty acid ester and the like. Examples thereof include fatty acid ester-based nonionic surfactants. When the HLB is outside the range of 5 to 10, the stock solution and / or the aerosol composition tends to be separated and tends not to be uniform. In particular, diglycerin fatty acid esters such as diglyceryl monooleate, diglyceryl monostearate, and diglyceryl monoisostearate, and sorbitan fatty acid esters such as sorbitan monolaurate are preferable in that the lipophilic surfactant is highly effective.

  The content of the lipophilic surfactant is preferably 1 to 25% by weight, more preferably 5 to 20% by weight in the stock solution. When it is less than 1% by weight, the stock solution and the aerosol composition tend to be difficult to be uniform. Even if blending over 25% by weight, there is no difference in effect and the cost is increased. Furthermore, if the spray particles adhere to the floor, hair, skin, etc., they tend to be sticky.

  Examples of the oil-soluble active ingredient include insecticide ingredients such as phthalthrin, allethrin, permethrin, cismethrin, propulserin, resmethrin, d-phenothrin, tefluthrin, vanfluthrin, imiprothrin, neopinamine forte, chryslon forte, cinepilin, pipette Efficacy enhancers such as ronylbutoxy, octachlorodipropyl ether, lauryl methacrylate, geranyl crotolate, acetophenone myristate, benzyl acetate, benzyl propionate, methyl phenylacetate, N, N-diethyl-m -Pest repellents such as toluamide (diet), UV absorbers such as isopropyl paramethoxycinnamate and 2,4-dihydroxybenzophenone, α-tocopherol, dibutylhydroxytoluene Any antioxidant, vitamins such as retinol, dl-α-tocopherol, anti-inflammatory agents such as glycyrrhetinic acid, antifungal agents such as miconazole nitrate, sulconazole nitrate, clotrimazole, methyl salicylate, indomethacin, felbinac, ketoprofen, etc. Anti-inflammatory analgesics, refreshing agents such as l-menthol and camphor, and fragrances.

  The content of the oil-soluble active ingredient is preferably 0.001 to 10% by weight, more preferably 0.005 to 5% by weight in the stock solution. If it is less than 0.001% by weight, the active ingredient concentration tends to be low and the effect of containing the active ingredient tends to be difficult to obtain. If it exceeds 10% by weight, it becomes easy to inject an excessive amount, and depending on the active ingredient, the user may be adversely affected.

  The oily component can be prepared by dissolving the lipophilic surfactant or the oil-soluble active ingredient in an oily solvent that is liquid at room temperature.

  Aqueous components are used to give the stock solution no flash point and to provide safety against fire. When injected into the atmosphere, the aqueous solution is refined by vaporization of a propellant composed mainly of hydrocarbons having 3 to 5 carbon atoms. To be diffused in space. Moreover, you may contain an active ingredient as needed, and in that case, it adheres to an injection target object and provides an active ingredient.

  Here, the undiluted solution does not have a flash point in the test specified in “Article 1-6 of the Decree on the Regulation of Dangerous Goods” when the undiluted solution does not ignite until it is heated from room temperature to boiling. Say. The flash point is measured with a tag-sealed flash point measuring device in the range from room temperature to 80 ° C., or when the flash point cannot be measured up to 80 ° C. with a Cleveland open flash point measuring device.

  The content of the aqueous component is preferably 10 to 50% by weight, more preferably 15 to 40% by weight in the stock solution. If the amount is less than 10% by weight, the stock solution tends to have a flash point, and the safety against fire tends to decrease. If it exceeds 50% by weight, the stock solution and the aerosol composition tend to be difficult to be uniform.

  The aqueous component can be obtained by blending a hydrophilic surfactant, a polyhydric alcohol, a water-soluble active ingredient and the like in an aqueous solvent.

  Examples of the aqueous solvent include water such as purified water, ion exchange water, and physiological saline. In addition, if both the stock solution and the aerosol composition, which are the characteristics of the present invention, are uniform and the stock solution does not have a flash point, an aqueous alcohol solution in which a lower alcohol such as ethanol or isopropyl alcohol is mixed with the water is used. Also good. The alcohol concentration of the aqueous alcohol solution is preferably less than 10% by weight, more preferably less than 5% by weight.

  The content of the aqueous medium is preferably 5 to 40% by weight, more preferably 10 to 35% by weight in the stock solution. If it is less than 5% by weight, the stock solution tends to have a flash point, and the safety against fire tends to be low. If it exceeds 40% by weight, the stock solution and the aerosol composition tend to be difficult to be uniform.

  The hydrophilic surfactant is uniform when an aqueous component is blended with an oil component to form a stock solution, and when a propellant mainly composed of hydrocarbons having 3 to 5 carbon atoms is blended to form an aerosol composition. In order to maintain the uniform state of the stock solution without separating the oily component and the aqueous component even when stored at high and low temperatures, the aerosol composition is further used to maintain the uniform state. .

  Examples of the hydrophilic surfactant include polyglycerin fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyethylene glycol fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene sorbite fatty acid ester, Nonionic surfactants having an HLB of 15 to 19, more preferably 15.5 to 18, such as oxyethylene glycerin fatty acid ester, polyoxyethylene castor oil / hardened castor oil, and polyoxyethylene lanolin alcohol. If the HLB is outside the range of 15 to 19, the stock solution and the aerosol composition tend to be difficult to be uniform. In particular, POE (n) oleyl ether (EO polymerization degree n = 15-40), POE (n) stearyl ether (n = 20-50), POE (n ) Polyoxyethylene alkyl ethers such as cetyl ether (n = 15-40), POE (n) behenyl ether (n = 20-30), POE (n) lauryl ether (n = 19-40) are preferred.

  The content of the hydrophilic surfactant is preferably 0.5 to 15% by weight, more preferably 1 to 10% by weight in the stock solution. When it is less than 0.5% by weight, the stock solution and the aerosol composition tend to be difficult to be uniform. Even if it contains more than 15% by weight, there is no difference in effect and the cost becomes high. Furthermore, if the spray particles adhere to the floor, hair, skin, etc., they tend to be sticky.

  The hydrophilic surfactant may be dissolved or dispersed in the oil component. In addition to the hydrophilic surfactant and lipophilic surfactant, other nonionic surfactants, cationic surfactants, anionic surfactants, amphoteric surfactants, silicone surfactants, etc. May be blended.

  The polyhydric alcohol is used to keep both the stock solution and the aerosol composition uniform, and to maintain a uniform state without separation even when stored at a high temperature and a low temperature. Furthermore, the flash point of the undiluted solution is not recognized, and it is used to prevent the undiluted solution from being classified as a dangerous substance under the Fire Service Act. Examples of the polyhydric alcohol include propylene glycol, 1,3-butylene glycol, ethylene glycol, diethylene glycol, dipropylene glycol, glycerin and the like. In particular, propylene glycol and 1,3-butylene glycol are preferable in that the effect of the polyhydric alcohol is high.

  When blending the polyhydric alcohol, the blending amount is preferably 0.5 to 20% by weight, more preferably 1 to 15% by weight in the stock solution. If it is less than 0.5% by weight, the effect of the polyhydric alcohol tends to be difficult to obtain. If it exceeds 20% by weight, the oily component and the aqueous component are easily separated, and it is difficult to obtain a uniform stock solution and aerosol composition.

  Examples of water-soluble active ingredients include paraoxybenzoic acid esters, sodium benzoate, phenoxyethanol, benzalkonium chloride, chlorhexidine chloride, parachlormetacresol, isopropylmethylphenol, and other disinfecting / preservatives, dialkylaminoethyl (meth) Acrylate- (meth) acrylic acid alkyl ester copolymer, acrylic acid octylamide-hydroxypropyl acrylate-butylaminoethyl methacrylate copolymer, vinylpyrrolidone-vinyl acetate copolymer, hydroxyethyl acrylate-butyl acrylate- Hair styling agent such as methoxyethyl acrylate copolymer, alkanolamine acrylate-vinylpyrrolidone-N, N-dimethylaminoethyl methacrylic acid copolymer sulfate, stearyl chloride Treatment agents such as limethylammonium, antihistamines such as diphenhydramine hydrochloride, local anesthetics such as dibucaine hydrochloride and lidocaine hydrochloride, antipruritic agents such as crotamiton and urea, polyoxyethylene glycol, glycerin, xylitol, sorbitol, maltitol, hyaluronic acid, humectants such as dl-pyrrolidone carboxylate, vitamins such as nicotinic acid amide and pantothenic acid, amino acids such as arginine, aspartic acid, cysteine, methionine, serine, leucine and tryptophan, dipotassium glycyrrhizinate, allantoin, and azulene acid Anti-inflammatory component, Dokudami extract, Agaric extract, Peonies extract, Loofah extract, Kina extract, Primrose extract, Rose extract, Giant extract, Lemon extract, A Eekisu, eucalyptus extract, sage extract, tea extract, seaweed extract, horse chestnut extract, peach, peach leaf extract, placenta extract, various extracts, such as silk extract, such as perfumes and the like.

When the water-soluble active ingredient is blended, the blending amount is preferably 0.001 to 10% by weight, more preferably 0.005 to 5% by weight in the stock solution. When the blending amount of the water-soluble active ingredient is less than 0.001% by weight, the concentration of the active ingredient is low and the desired effect tends not to be obtained. Exceeding 10% by weight makes it easy to inject excessive amounts, and some active ingredients may adversely affect the user. Aqueous components are hydrophilic surfactants, polyhydric alcohols, water-soluble It can be prepared by dissolving the components in an aqueous solvent.

  The stock solution can be prepared by mixing the oily component and the aqueous component. The blending amount of the stock solution is preferably 10 to 65% by weight, more preferably 20 to 60% by weight in the aerosol composition. When the amount is less than 10% by weight, the spray particles become too small and the user can easily suck. If it exceeds 65% by weight, the spray particles become coarse and the diffusibility in the space becomes poor, or it becomes difficult to uniformly adhere to the skin and hair.

  The hydrocarbon having 3 to 5 carbon atoms used as the main component of the propellant is a liquid having a vapor pressure inside the aerosol container, and dissolves with the oil component to become a main solvent. Further, when it is sprayed to the outside, it vaporizes and refines the oily component and aqueous component. When the number of carbon atoms is less than 3, the vapor pressure is too high to fill the aerosol container. When the number of carbon atoms exceeds 5, the vapor pressure is low, and even if injected into the atmosphere, it is difficult to vaporize, so it does not form a fine mist.

  Here, having 3 to 5 carbon atoms as a main component means that the content of hydrocarbons having 3 to 5 carbon atoms is 70 to 100% by weight in the propellant. The content is preferably 75 to 100% by weight. When it is less than 70% by weight, the aerosol composition is easily separated and cannot maintain a uniform state.

  The content of the propellant is preferably 35 to 90% by weight, more preferably 40 to 80% by weight in the aerosol composition. If it is less than 35% by weight, the spray particles become coarse and the residence time in the space is shortened, resulting in poor diffusibility and difficulty in uniformly adhering to the skin and hair. When it exceeds 90% by weight, the content of the aqueous component in the aerosol composition is reduced, and the safety against fire is lowered. Further, the spray particles tend to be too small, and the user tends to suck them.

  Examples of the hydrocarbon having 3 to 5 carbon atoms include propane, normal butane, isobutane, normal pentane, and isopentane.

  It should be noted that dimethyl ether may be mixed with the propellant as long as the aerosol composition can maintain a uniform state. The content of dimethyl ether is preferably 1 to 25% by weight, more preferably 5 to 20% by weight in the aerosol composition. If it is less than 1% by weight, the effect of dimethyl ether tends to be difficult to obtain. If it exceeds 25% by weight, the aerosol composition tends to be separated and tends to be unable to maintain a uniform state. Further, a compressed gas such as nitrogen gas, carbon dioxide gas, compressed air, or nitrous oxide gas may be filled.

  Furthermore, the aerosol composition of the present invention may be blended with powder as a simple substance carrying an active ingredient or as an adhesive for facilitating adhesion to an injection target. Examples of the powder include inorganic powders such as talc, corn starch, silica, zinc undecylenate, magnesium silicate, mica, titanium mica, magnesium oxide, zinc oxide, titanium oxide, magnesium carbonate, calcium carbonate, nylon 6, nylon 66, nylon 12 And the like, and organic powders such as polyamide, polyethylene, polypropylene, polystyrene, polycarbonate, polyester, acrylic resin, fluororesin, and silicone resin, and viscosity minerals such as bentonite and kaolinite. When blending the powder, the blending amount is preferably 0.1 to 10% by weight, more preferably 0.5 to 5% by weight in the aerosol composition. When the content of the powder is less than 0.1% by weight, the effect of the powder tends to be difficult to obtain. If it exceeds 10% by weight, it tends to be difficult to inject with a uniform composition, and further tends to be clogged with an aerosol valve or an injection member.

  As a method for producing the aerosol composition of the present invention, for example, an oleophilic surfactant or an oil-soluble active ingredient is dissolved in an oily solvent that is liquid at room temperature to prepare an oily component. On the other hand, a hydrophilic surfactant or a water-soluble active ingredient is dissolved in an aqueous solvent to prepare an aqueous ingredient. Next, an oily component and an aqueous component are mixed to prepare a uniform stock solution. The obtained undiluted solution is filled into a pressure resistant container, further filled with a propellant, and a valve is fixed to the opening of the pressure resistant container. A uniform aerosol composition is prepared by mixing the stock solution and the propellant inside the container, for example, by shaking the container.

  The oily component and the aqueous component may be filled separately as in the conventional filling method. Further, a uniform aerosol composition can be prepared by previously mixing an oily component, an aqueous component, and a propellant in a tank or the like, and can be filled in a container to which a valve is fixed.

In addition, as a pressure | voltage resistant container, what shape | molded the bottomed cylindrical shape of metals, such as aluminum and tinplate, synthetic resins, such as a polyethylene terephthalate, pressure | voltage resistant glass, etc. can be used.
In particular, when a metal container is used as a pressure vessel, the inner surface is spray-coated with a synthetic resin such as epoxyphenol, polyamideimide, epoxy urea, epoxymelamine, or polyvinylidene fluoride, nylon, polyethylene, polypropylene, polyethylene terephthalate. It is preferable to provide protective means such as those obtained by laminating a resin film such as nylon, polyethylene, polypropylene, polyethylene terephthalate or the like in which powdery resin is powder-coated by electrostatic coating or the like. Furthermore, you may insert the inner bag shape | molded by the bottomed cylinder shape with synthetic resins, such as nylon, polyethylene, and a polypropylene, in the pressure | voltage resistant container. In this case, the aerosol composition is filled into the inner bag, and the inner bag has the same function as the inner surface coat.

  The aerosol composition of the present invention comprises a stock solution containing an aqueous component and an oily component and a propellant mainly composed of a hydrocarbon having 3 to 5 carbon atoms, and since the stock solution and the aerosol composition are both uniform, the spray composition is sprayed. Since the particles are refined and have excellent diffusibility in the space, they are suitably used as space aerosol products such as insecticides, deodorants, and fragrances. Furthermore, since it easily adheres uniformly to the skin and hair, aerosol products for hair such as styling agents, treatment agents, and coloring agents, insecticides, anti-inflammatory analgesics, antifungal agents, antifungal agents, and insect repellents. It is also preferably used for aerosol products for skin.

  EXAMPLES Hereinafter, although this invention is demonstrated in detail based on an Example, this invention is not limited only to these.

Example 1
An oily component and an aqueous component were respectively prepared in the ratios shown in Table 1, and these were mixed to prepare a stock solution. The obtained stock solution was filled in a pressure vessel (made of polyethylene terephthalate, full volume 30 ml), filled with a hydrocarbon having 3 to 4 carbon atoms as a propellant, and an aerosol valve was fixed to the opening of the pressure vessel. An aerosol composition was prepared by shaking the pressure vessel up and down several times. The appearance of the stock solution, the presence or absence of stock solution separation, the flash point of the stock solution, the appearance of the aerosol composition, the transmittance of the stock solution, and the transmittance of the aerosol composition were evaluated. The results are shown in Table 3.

* 1: Neothiozole (Chuo Kasei Co., Ltd., kerosene, flash point 96 ° C)
* 2: LP-20R (manufactured by NOF Corporation, HLB8.6)
* 3: BO-20V (Nikko Chemicals, HLB17.0)
* 4: Mixture of propane, normal butane and isobutane (vapor pressure at 25 ° C: 0.44 MPa)

<Test items>
1. Appearance of Stock Solution Regarding the presence or absence of separation of the stock solution at room temperature (25 ° C.), the stock solution was prepared and allowed to stand for 1 month.

Evaluation criteria A: Uniform (colorless and transparent. Transmittance 90 to 100%).
○: Uniform (slightly white, transmittance 70-90%).
Δ: non-uniform (translucent to white, transmittance 70% or less).
X: Separation (without measuring transmittance).

2. Presence / absence of separation of stock solution Regarding the presence / absence of separation of the stock solution at room temperature (25 ° C.), the stock solution was prepared and allowed to stand for 1 month.

Evaluation criteria A: No separation.
○: Slightly sedimented, but disappears when shaken once.
(Triangle | delta): Although there exists a sediment, it will disappear when it shakes 2-3 times.
X: There is a sediment that does not disappear even after complete separation or shaking.

3. The flash point of the undiluted solution The flash point is measured with a tag-closed flash point measuring device in the range from room temperature to 80 ° C, or with a Cleveland release flash point measuring device if the flash point cannot be measured up to 80 ° C. It was.

Evaluation criteria ○: None ×: Available

4). Appearance of the aerosol composition The aerosol composition was allowed to stand at room temperature (25 ° C), high temperature (45 ° C), and low temperature (5 ° C) for 1 month, and the appearance of the aerosol composition was evaluated. The evaluation criteria were the same conditions as the appearance evaluation of the stock solution.

5). Presence / absence of separation of aerosol composition The aerosol composition was allowed to stand for 1 month at room temperature (25 ° C), high temperature (45 ° C), and low temperature (5 ° C), and the presence or absence of separation of the aerosol composition was evaluated. The evaluation criteria were the same as in the evaluation of whether or not the stock solution was separated.

6). Transmittance of undiluted solution and aerosol composition Using a color difference meter (CT-210, manufactured by Minolta Co., Ltd.) and using standard light (pulse xenon lamp), a light beam Φt that passes through the undiluted solution or the aerosol composition and an incident light beam Φi The ratio (Φt / Φi, defined by JIS Z 8105) was calculated based on the value expressed as a percentage. In addition, the transmittance | permeability of the undiluted | stock solution and the aerosol composition was measured about the same sample which evaluated the external appearance of the said undiluted | stock solution and the external appearance of an aerosol composition.

Example 2
An aerosol composition was prepared in the same manner as in Example 1 except that POE (30) oleyl ether (* 5) was used instead of POE (20) oleyl ether. Evaluation was performed in the same manner as in Example 1. The results are shown in Table 3.
* 5: BROWNON EN-1530 (Aoki Yushi Co., Ltd., HLB16.5)

Example 3
An aerosol composition was prepared in the same manner as in Example 1 except that POE (15) oleyl ether (* 6) was used instead of POE (20) oleyl ether. Evaluation was performed in the same manner as in Example 1. The results are shown in Table 3.
* 6: BO-15V (Nikko Chemicals Co., Ltd., HLB16.0)

Example 4
An oily component and an aqueous component were respectively prepared in proportions shown in Table 2, and these were mixed to prepare a stock solution. The obtained stock solution was filled in a pressure vessel (made of polyethylene terephthalate, full volume 30 ml), filled with a hydrocarbon having 3 to 4 carbon atoms as a propellant, and an aerosol valve was fixed to the opening of the pressure vessel. An aerosol composition was prepared by shaking the pressure vessel up and down several times. Evaluation was performed in the same manner as in Example 1. The results are shown in Table 3.

Example 5
An aerosol composition was prepared in the same manner as in Example 4 except that diglyceryl monooleate (* 7) was used instead of sorbitan monolaurate. Evaluation was performed in the same manner as in Example 1. The results are shown in Table 3.
* 7: GDMO-C (Nikko Chemicals, HLB5.5)

Example 6
An aerosol composition was prepared in the same manner as in Example 4 except that diglyceryl monostearate (* 8) was used instead of sorbitan monolaurate. Evaluation was performed in the same manner as in Example 1. The results are shown in Table 3.
* 8: DGMIS (Nikko Chemicals, HLB5.5)

Comparative Example 1
An aerosol composition was prepared in the same manner as in Example 4 except that POE (30) POP (6) decyl tetradecyl ether (* 9) was used instead of POE (20) oleyl ether. Evaluation was performed in the same manner as in Example 1. The results are shown in Table 3.
* 9: PEN-4630 (Nikko Chemicals, HLB 12.0)

Comparative Example 2
An aerosol composition was prepared in the same manner as in Example 4 except that POE (20) POP (4) cetyl ether (* 10) was used instead of POE (20) oleyl ether. Evaluation was performed in the same manner as in Example 1. The results are shown in Table 3.
* 10: PBC-34 (Nikko Chemicals, HLB16.5)

Comparative Example 3
An aerosol composition was prepared in the same manner as in Example 4 except that POE (100) hydrogenated castor oil (* 11) was used instead of POE (20) oleyl ether. Evaluation was performed in the same manner as in Example 1. The results are shown in Table 3.
* 11: HCO-100 (manufactured by Nikko Chemicals, HLB16.5)

Comparative Example 4
An aerosol composition was prepared in the same manner as in Example 4 except that POE (20) sorbitan (* 12) monooleate was used instead of POE (20) oleyl ether. Evaluation was performed in the same manner as in Example 1. The results are shown in Table 3.
* 12: TO-10M (manufactured by Nikko Chemicals, HLB 15.0)

Comparative Example 5
An aerosol composition was prepared in the same manner as in Example 4 except that sorbitan sesquioleate (* 13) was used instead of sorbitan monolaurate. Evaluation was performed in the same manner as in Example 1. The results are shown in Table 3.
* 13: SO-15R (Nikko Chemicals, HLB4.5)

Comparative Example 6
An aerosol composition was prepared in the same manner as in Example 4 except that decaglyceryl pentaoleate (* 14) was used instead of sorbitan monolaurate. Evaluation was performed in the same manner as in Example 1. The results are shown in Table 3.
* 14: Decaglyn 5-O (Nikko Chemicals HLB3.5)

Comparative Example 7
An aerosol composition was prepared in the same manner as in Example 4 except that POE (5) hydrogenated castor oil (* 15) was used instead of sorbitan monolaurate. Evaluation was performed in the same manner as in Example 1. The results are shown in Table 3.
* 15: HCO-5 (Nikko Chemicals, HLB 6.0)

Comparative Example 8
An aerosol composition was prepared in the same manner as in Example 4 except that POE (1) POP (4) cetyl ether (* 16) was used instead of sorbitan monolaurate. Evaluation was performed in the same manner as in Example 1. The results are shown in Table 3.
* 16: PBC-31 (Nikko Chemicals, HLB9.5)

Comparative Example 9
An aerosol composition was prepared in the same manner as in Example 4 except that POE (20) oleyl ether was not used and purified water was 8.75% by weight. Evaluation was performed in the same manner as in Example 1. The results are shown in Table 3.

Comparative Example 10
An aerosol composition was prepared in the same manner as in Example 4 except that sorbitan sesquioleate (* 13) was used instead of sorbitan monolaurate, POE (20) oleyl ether was not used, and purified water was 8.75% by weight. Prepared. Evaluation was performed in the same manner as in Example 1. The results are shown in Table 3.

Comparative Example 11
Aerosol composition as in Example 4 except that POE (2) lauryl ether (* 17) was used instead of sorbitan monolaurate, POE (20) oleyl ether was not used, and purified water was 8.75% by weight. A product was prepared. Evaluation was performed in the same manner as in Example 1. The results are shown in Table 3.
* 17: BL-2 (Nikko Chemicals, HLB9.5)

Product example (space insecticide)
An oily component and an aqueous component shown in Table 4 were prepared, and these were mixed to prepare a stock solution. The obtained undiluted solution was filled in a pressure vessel (manufactured by Tinplate, full-filled amount 400 ml), filled with a hydrocarbon having 3 to 4 carbon atoms as a propellant, and an aerosol valve was fixed to the opening of the pressure vessel. 200 g of an aerosol composition was prepared by shaking the pressure vessel up and down several times. A valve having a stem hole of φ0.4, a housing having a lower hole of φ0.55, and a horizontal hole of φ0.42 was used.

Claims (2)

And uniform stock solution comprising an aqueous component and an oily component, Ri Do and a propellant composed mainly of hydrocarbons having 3 to 5 carbon atoms,
The stock solution contains a surfactant having an HLB of 5 to 10 and a surfactant having an HLB of 15 to 19,
The uniform aerosol composition in which the surfactant having 5 to 10 HLB is a fatty acid ester and the surfactant having 15 to 19 HLB is a polyoxyethylene alkyl ether . Stock solution, according to claim 1 Symbol placement of the aerosol composition, characterized in that no flash point.