JP4266453B2 - Biological light measurement device - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a biological light measurement device, and more particularly to a technique that is effective when applied to the generation of a biological passing light intensity image along the body surface shape of a biological body.
[0002]
[Prior art]
Conventionally, an apparatus for measuring the inside of a living body simply and without causing harm to the living body has been eagerly desired in the fields of clinical medicine and brain science. In response to this demand, an apparatus for measuring the inside of a living body by irradiating the living body with light having a wavelength from visible to infrared and detecting the light passing through the living body is disclosed in, for example, Japanese Patent Laid-Open No. 9-98972 (hereinafter referred to as “Document”). 1) or JP-A-9-149903 (hereinafter referred to as “Document 2”).
[0003]
The “biological light measurement device” described in these documents includes a modulated semiconductor laser that generates light of different modulation frequencies, an irradiation optical fiber that guides the generated light to the living body and irradiates it to different positions, and passes through the living body. Represents the detection optical fiber that collects the collected light and guides it to the photodiode, the measurement probe that fixes the tip portions of the irradiation and detection optical fibers to predetermined positions of the living body, and the living body passage intensity output from the photodiode A lock-in amplifier that separates reflected light intensity corresponding to a wavelength and an irradiation position from an electrical signal (hereinafter referred to as “biological passage intensity signal”), and an A / D converter that converts the output of the lock-in amplifier into a digital signal Then, the relative change amount of the oxidized and reduced hemoglobin concentration at each measurement point is calculated from the biological passage intensity signal after A / D conversion, and this relative change amount is calculated as the biological passage intensity image. It was composed of a display device for displaying a (topographic image).
[0004]
In this conventional biological light measurement device, a fixing member called a probe holder for fixing the irradiation optical fiber and the detection optical fiber is formed on the measurement probe, and the topography is based on the position of the probe holder on the measurement probe. An image was generated and displayed. That is, in the conventional biological light measurement device, a topographic image is generated based on the attachment positions on the two-dimensional plane of the irradiation and detection optical fibers arranged on the measurement probe, and the two-dimensional plane imitating the measurement part of the biological body The topography image is aligned on the image, and the topography image is displayed in the same display area together with the two-dimensional planar image.
[0005]
[Problems to be solved by the invention]
As a result of examining the prior art, the present inventor has found the following problems.
In the conventional biological light measurement device, for example, when the head is used as a measurement site, it is possible to measure the activation state of hemoglobin change in the brain and local cerebral hemorrhage. However, the conventional biological light measurement device has a problem that it cannot easily and accurately specify in which region of the brain the hemoglobin change or the like has occurred.
[0006]
That is, in a conventional biological light measurement device, a hemoglobin change region is specified by projecting an image serving as a measure of a measurement site onto a topography image, such as the central groove of the brain. The position of the reference image and the topography image at this time is based on the wearing state of the measurement probe, and the examiner has projected the reference image onto the topography image. It was not possible to grasp easily what happened.
[0007]
An object of the present invention is to provide a technique capable of clarifying a positional relationship between a light irradiation position and a light detection position arranged three-dimensionally and a topography image.
[0008]
Another object of the present invention is to provide a technique capable of easily grasping the change amount and change region of the hemoglobin amount at the measurement site.
[0009]
Another object of the present invention is to provide a technique capable of improving diagnostic efficiency.
The above and other objects and novel features of the present invention will be apparent from the description of this specification and the accompanying drawings.
[0010]
[Means for Solving the Problems]
Of the inventions disclosed in this application, the outline of typical ones will be briefly described as follows.
(1) means for irradiating a subject with light from a plurality of light irradiation positions, and light irradiated from the plurality of light irradiation positions and passed through the inside of the subject is installed in the vicinity of the plurality of light irradiation positions A living body comprising light detection means for detecting at a plurality of detection positions, and signal processing means for creating a topographic image representing the biological information inside the subject by using the light amount at each detection position detected by the light detection means. In the optical measurement apparatus, the signal processing means includes means for setting three-dimensional coordinate data representing a positional relationship between the light irradiation position and the light detection position and a reference point provided on the subject, and the three-dimensional coordinate data. Means for creating a three-dimensional topography image based on the three-dimensional coordinate data indicating the positional relationship between the light irradiation position and the light detection position, and the three-dimensional coordinate data of the three-dimensional morphological image of the subject. Characterized in that it comprises a means for creating and displaying a composite image of the said form image and the three-dimensional topographic image Te Align.
[0011]
(2) In the biological optical measurement device according to (1) , the signal processing means further includes means for arranging the three-dimensional topography image within a predetermined depth from the surface of the subject in the three-dimensional morphological image. It is characterized by including.
[0012]
(3) The biological light measurement apparatus according to (1) , further including means for inputting three-dimensional morphological image data of the subject.
[0013]
(4) In the biological light measurement device according to (1) , the signal processing means includes means for creating a wire frame image of the subject as the morphological image.
[0014]
(5) In the biological light measurement device according to (1) , the morphological image includes a tomographic image.
[0015]
(6) In the biological light measurement device according to (5), the morphological image includes a CT image.
[0016]
(7) In the biological light measurement device according to (5), the morphological image includes an MRI image.
[0019]
DETAILED DESCRIPTION OF THE INVENTION
Hereinafter, the present invention will be described in detail with reference to the drawings together with embodiments (examples) of the invention.
Note that components having the same function are denoted by the same reference symbols throughout the drawings for describing the embodiment of the invention, and the repetitive description thereof is omitted.
[0020]
"overall structure"
FIG. 1 is a diagram for explaining a schematic configuration of a biological light measurement device according to an embodiment of the present invention. 1 is a light source unit, 2 is an optical module, 3 is an oscillation unit, 8 is an irradiation optical fiber, 9 is a measurement object, 10 is a detection optical fiber, 11 is a photodiode, 12 is a lock-in amplifier module, 16 is an A / D converter, 17 is control means, 18 is recording means, 19 is processing means (image generation means) ), 20 indicates display means, and 21 indicates a three-dimensional position detection means (measurement means). However, the processing of the measurement values in the control means 17 and the processing means 19 and other configurations except for the three-dimensional position detection means 21 use known means and mechanisms.
[0021]
In the present embodiment, for example, when light is irradiated from the skin surface of the head of the human body as the measurement object 9 and the brain function is imaged from the passing light detected on the skin surface of the head, the number of measurement channels, that is, A case where the measurement position is 12 will be described. Of course, the present invention can be applied to a living body other than the human body and a part other than the head or other than the living body as the measurement object 9. Further, by increasing or decreasing the number of light irradiation positions and light detection positions, it is possible to increase or decrease the number of measurement channels, that is, measurement positions, and it is also possible to expand, decrease, or deform the measurement region.
[0022]
In FIG. 1, the light source unit 1 is composed of four optical modules 2. Each optical module 2 is composed of two semiconductor lasers (not shown) that emit light of a plurality of wavelengths, for example, 780 nm and 830 nm, in the visible to infrared wavelength region. These two wavelength values are not limited to 780 nm and 830 nm, and the number of wavelengths is not limited to two wavelengths. For the light source unit 1, a light emitting diode may be used instead of the semiconductor laser. Eight semiconductor lasers, which are all semiconductor lasers included in the light source 1, are modulated by the oscillating unit 3 composed of oscillators (not shown) having different oscillation frequencies. However, as this modulation, the present embodiment shows a case of analog modulation using a sine wave, but the present invention is not limited to this, and digital modulation using rectangular waves at different time intervals may be used. Further, in the optical module 2, a driving circuit (not shown) for driving each semiconductor laser and light having wavelengths of 780 nm and 830 nm emitted from the respective semiconductor lasers are introduced into one optical fiber (irradiation optical fiber 8). And an optical fiber coupler (not shown).
[0023]
Therefore, the light mixed with the two-wavelength light emitted from the light source unit 1 is guided by the four irradiation optical fibers 8 whose one ends are connected to each optical module 2 and is measured from the tip portion which is the other end. 9 is irradiated. At this time, the other end side of each irradiation optical fiber 8 is fixed to a measurement probe (not shown) and irradiates light at different positions. However, in the present embodiment, the tip portions of the irradiation optical fiber 8 and the detection optical fiber 10 are alternately arranged on a square lattice. Details of the measurement probe are described in Document 2, for example.
[0024]
The light passing through the head, that is, the light passing through the living body is condensed by five detection optical fibers 10 each having one end fixed to a measurement probe (not shown), and connected to the other end of each detection optical fiber 10. It is detected by a photodiode 11 which is a photodetector. As the photodiode 11, a known avalanche photodiode capable of realizing highly sensitive optical measurement is desirable. Further, as the photodetector, any other photoelectric conversion element such as a photomultiplier tube may be used.
[0025]
The light passing through the living body is converted into an electric signal (hereinafter referred to as “biological passing light intensity signal”) by these photodiodes 11 and then constituted by, for example, a plurality of lock-in amplifiers which are selective detection circuits for the modulation signal. The lock-in amplifier module 12 selectively detects the modulation signal corresponding to the irradiation position and wavelength. At this time, the modulation signal output from the lock-in amplifier module 12 is separated into a biological passage intensity signal corresponding to the wavelength and the irradiation position. However, in the present embodiment, since measurement is performed at 12 measurement positions using light of two wavelengths, the number of signals to be measured is 24. Therefore, the lock-in amplifier module 12 of the present embodiment uses a total of 24 lock-in amplifiers (not shown). However, when digital modulation is used, it is possible to use a digital filter or a digital signal processor for detecting the modulation signal.
[0026]
The biological passage light intensity signal analog-output from the lock-in amplifier module 12 is converted into a digital signal by a 24-channel A / D converter (analog / digital converter) 16. Each digital signal is a biological light intensity signal for each wavelength and irradiation position.
[0027]
The measurement operation described above is the same as the measurement operation by the conventional biological light measurement device, and this measurement operation is controlled by the control means 17. Further, the measurement signal processing operation unique to the biological light measurement apparatus of the present embodiment described below is also controlled by the control means 17.
[0028]
As a measurement unique to the biological light measurement device of the present embodiment, it is necessary to specify the external shape of the measurement object 9 by the three-dimensional position detection means 21 before or after the start of the biological light measurement for the measurement object 9. Three-dimensional position measurement of a part (hereinafter referred to as “reference position”), and three-dimensional position of contact between the irradiation optical fiber 8 and detection optical fiber 10 and the measurement object 9 (hereinafter referred to as “probe position”). Perform position measurement. Specifically, the following five reference points are measured as reference positions. The positions of the left ear position, the right ear position, the dent position (nadion), and the back of the head (inion). Next, the probe position is measured in the order of the channels assigned to all fibers. The positional relationship between the reference position and the probe position is clarified by converting the coordinate data of the probe position obtained here to the coordinates from the previously specified reference point. The measured reference position and probe position are recorded in the recording means 18. However, the three-dimensional position detection means 21 is referred to as a neuronavigator described in, for example, “Hidetoshi Watanabe:“ Current Status and Future of Neuronavigator ”, Advanced Medicine, Vol. 5, No. 2, pp76-78, 1998”. This can be realized by using position detecting means.
[0029]
On the other hand, the living body passage light intensity signal converted into the digital signal is recorded by the recording means 18. The living body passage light intensity signal recorded in the recording means 18 is read out by the processing means 19, and the processing means 19 performs oxygenation accompanying brain activity obtained from the living body passage light intensity signal for each measurement position of the living body passage light. A topographic image is calculated that shows the hemoglobin concentration change and deoxygenated hemoglobin concentration change, and further the total hemoglobin concentration corresponding to the blood flow. However, the distance between the optical fibers at this time is 30 mm, which is the distance between the measurement probes that fix the optical fibers to the measuring object 9. Next, the processing means 19 reads the three-dimensional position information of the probe position from the recording means 18, and the processing means 19 calculates the distance between the optical fibers at each measurement position based on the probe position information. Next, the topography image indicating the oxygenated hemoglobin concentration change, the deoxygenated hemoglobin concentration change and the total hemoglobin concentration is corrected by the distance between the optical fibers in the three-dimensional space at the time of measurement obtained by calculation, and a plurality of correction values are corrected. Is displayed on the display screen of the display means 20 as time-lapse information at the measurement position. At this time, in the biological light measurement device of the present embodiment, the processing unit 19 reads out the reference position information that is the three-dimensional information of the outer shape of the measurement target 9 from the recording unit 18, and based on the reference position information, The processing means 19 generates the outer shape of the measurement object 9 as a wire frame image that is an image indicated by the contour and a plurality of ellipses, and the corrected oxygenated hemoglobin concentration change, deoxygenated hemoglobin concentration change, and total hemoglobin concentration are obtained. It is displayed on the display screen of the display means 20 together with the topographic image shown. Further, the processing means 19 displays the contact positions of the irradiation optical fiber 8 and the detection optical fiber 10 and the measurement object 9 together with the topography image on the display surface. This makes it possible to clarify the positional relationship between the topographic image displayed three-dimensionally, the irradiation position, and the detection position. Therefore, it is possible to accurately specify the amount of change and the change region of the hemoglobin amount at the measurement site. As a result, the diagnostic efficiency of the examiner can be improved. The method for calculating the oxygenated and deoxygenated hemoglobin concentration change and the total hemoglobin concentration from the in-vivo light intensity signal at each measurement position is described in Reference 1 and Reference 2, and detailed description thereof will be omitted. .
[0030]
Next, FIG. 2 shows a diagram for explaining the details of the generation operation of the living body passage light intensity image in the processing means of the present embodiment. Hereinafter, the generation of the topography image in the processing means 19 based on FIG. Explain the procedure. However, in the following description, only the generation operation that is different from the processing means in the conventional biological light measurement device will be described.
[0031]
The start of this flow is a topography image generation instruction from an input means (not shown), and specifically, a topography image generation start instruction output from the control means 17 to the processing means 19 based on the topography image generation instruction. is there. At this time, the control unit 17 records the three-dimensional position information 201 related to the head shape and the three-dimensional position information 202 related to the contact position between the irradiation and detection optical fibers 8 and 10 and the measurement object 9. To give the processing means 19 an output. However, the three-dimensional position information 201 is coordinate information of all reference positions measured for specifying the outer shape of the measurement target 9.
[0032]
The processing means 19 first generates a three-dimensional wire frame image of the head from the three-dimensional position information 201 obtained by measuring the shape of the head that is the measurement site of the measurement object 9. Specifically, by performing parabolic approximation using the XYZ coordinate system, using the coordinates of the five points (left ear position, right ear position, nasal cavity position (nadion), occipital region (initon)) measured as the reference position. The head-shaped wire frame image is generated.
[0033]
Next, the processing means 19 includes a light irradiation position (irradiation position) and a light detection position (three-dimensional position information 202 relating to the contact position between the tip portions of the irradiation and detection optical fibers 8 and 10 and the measurement object 9 ( Based on the three-dimensional position information of the (condensing position), a three-dimensional frame image of the head, which is the measurement site, is generated (configured) (step 203). Thereafter, the processing means 19 specifies and plots the light irradiation position and the light detection position on the generated three-dimensional frame image (step 204). Next, the processing means 19 generates a topographic image by setting the same procedure as before, that is, assuming that the distance between the light irradiation position and the light detection position is 30 mm, which is the design distance (step 205). In this step 205, for example, as shown in FIG. 3, it is assumed that the light irradiation positions and the light detection positions are arranged in a square lattice pattern with an interval of 30 mm in accordance with the head. In twelve measurement positions that are intermediate positions, the oxygenated hemoglobin concentration change, deoxygenated hemoglobin concentration change, and hemoglobin concentration when the brain is not stimulated and when the brain is stimulated Find the total change. Next, the value of the hemoglobin concentration change at each measurement position is imaged by, for example, cubic spline interpolation, and this image is used as a topography image. Note that details of obtaining a topography image from the value of hemoglobin concentration change by cubic spline interpolation are described in Document 1 and Document 2, and thus detailed description thereof is omitted.
[0034]
Next, the processing means 19 calculates a distance d in the three-dimensional space between the light irradiation position and the light detection position adjacent to the read light irradiation position and the light detection position 202 for each measurement position. At this time, since the number of measurement positions is 12 in this embodiment, the distance d in the three-dimensional space between the light irradiation position and the light detection position calculated by calculation is also 12. Next, the processing means 19 corrects the topographic image Hb data (original) based on the two-dimensional light irradiation position and the light detection position, which is a topographic image before correction, according to the following equation (1), and the corrected topography A topographic image Hb data (new) based on the three-dimensional light irradiation position and the light detection position as an image is generated (step 206). Specifically, the pixel value for each pixel of the topography image obtained by the cubic spline interpolation is corrected by the distance d of the measurement position closest to the pixel. The correction at this time follows the following formula 1 as described above.
[0035]
[Expression 1]
Hb data (new) = Hb data (original) × Distance (1)
However, Distance = d / 30
Next, the processing means 19 converts the corrected topography image into a topography image along the wire frame image generated in step 203. Specifically, the pixel value of each pixel constituting the topography image is converted into a three-dimensional topography image image by performing three-dimensional mapping interpolation according to the head wire frame coordinates.
[0036]
Thereafter, the processing unit 19 generates a three-dimensional image obtained by superimposing the topography image on the wire frame image, and the three-dimensional image viewed from the viewpoint position designated by the input unit (not shown) (hereinafter, “ The image is displayed on the display surface of the display means 20 (step 207), and the process ends. Therefore, in the biological light measurement device according to the first embodiment, a topography image along the wire frame image of the measurement object 9 can be generated.
[0037]
FIG. 4 is a diagram showing an example of a three-dimensional topography image displayed on the display means of the present embodiment. However, in the biological light measurement device of the present embodiment, a region where the hemoglobin concentration change amount due to stimulation is small is shown in blue, a region where the concentration change amount is large is shown in red, and an intermediate portion thereof is displayed in an intermediate color between blue and red Like to do. However, in FIG. 4, the red and blue portions are dithered in order to make it possible to see how the hemoglobin concentration changes.
[0038]
In FIG. 4, 401 is a wire frame image of the measurement object 9, 402 is a region where the hemoglobin concentration change amount is small, and 403 is a region where the hemoglobin concentration change amount is large. Also, the numbers displayed superimposed on the wire frame image 401 indicate the channel number of the measurement position, that is, the light irradiation position and the light detection position.
[0039]
As is clear from FIG. 4, the living body optical measurement device of the present embodiment can display the light irradiation position and the light detection position on the three-dimensional topography image together with the three-dimensional topography image that is the measurement result. Therefore, it is possible to accurately grasp the contact position between the irradiation optical fiber and the detection optical fiber and the measurement object 9. As a result, it is possible to easily grasp at which position of the measurement object 9 the hemoglobin concentration is changed, and the diagnostic efficiency can be improved.
[0040]
Furthermore, in the biological optical measurement device of the present embodiment, it is possible to perform a three-dimensional topographic image display in which a topographic image is displayed together with a wire frame image 401 that imitates the surface shape of the measurement site of the measurement target 9. Therefore, it is possible to accurately specify the change amount and change region of the hemoglobin amount at the measurement site. As a result, the diagnostic efficiency can be further improved.
[0041]
As described above, in the biological light measurement device of the present embodiment, the measurement object 9 arranged in the three-dimensional space with the X axis, the Y axis, and the Z axis that are not parallel to each other, the light irradiation position, and the light detection position. A three-dimensional position detection unit 21 for specifying is provided, and based on the outer shape of the measurement site, the light irradiation position, and the light detection position measured by the three-dimensional position detection unit 21, the outer shape, topography image, and light irradiation of the measurement site. A three-dimensional topography image in which a position and a light detection position are formed in a three-dimensional space is generated, and a three-dimensional topography image obtained by observing the three-dimensional topography image from a desired viewpoint position is displayed. Therefore, it is possible to accurately specify the change region of the hemoglobin amount with respect to the measurement site of the measurement object 9. As a result, the examiner can easily identify the change region of the hemoglobin amount with respect to the measurement site of the measurement target 9, and thus the diagnostic efficiency can be improved.
[0042]
Moreover, in the biological light measurement device of the present embodiment, the light irradiation position and the light detection position can be measured in a state where the measurement probe is attached to the measurement part, that is, the outer shape of the measurement part, the light irradiation position, and the light. It is possible to accurately measure the positional relationship with the detection position. As a result, there is an effect that the positional deviation between the wire frame image 401 indicating the outer shape of the measurement site in the three-dimensional topography image and the topography image displayed together with the wire frame image 401 can be minimized.
[0043]
In the biological optical measurement device of the present embodiment, first, oxygenated and deoxygenated hemoglobin concentration changes and total hemoglobin concentration are calculated for each measurement position at the design interval of the optical fiber at the time of measurement, and then the tertiary Although the optical fiber interval calculated from the original measured optical fiber position is configured to correct the oxygenated and deoxygenated hemoglobin concentration change and the total hemoglobin concentration for each measurement position, it is not limited to this. For example, first, the optical fiber interval at the time of measurement is calculated from the optical fiber position measured three-dimensionally, and based on the calculated optical fiber interval, the oxygenated and deoxygenated hemoglobin concentration change and Needless to say, the total hemoglobin concentration may be calculated.
[0044]
Further, in the biological light measurement device of the present embodiment, the outer shape of the measurement target 9 is a wire frame image, but is not limited to this, for example, by increasing the number of measurement points for the measurement target 9, for example, Needless to say, a three-dimensional stereoscopic display or the like obtained by creating a surface model of the measuring object 9 and performing a perspective transformation on the surface model as in the three-dimensional display on the X-ray CT apparatus.
[0045]
The invention made by the present inventor has been specifically described based on the embodiment of the invention, but the invention is not limited to the embodiment of the invention and does not depart from the gist of the invention. Of course, various changes can be made.
[0046]
【The invention's effect】
The effects obtained by the representative ones of the inventions disclosed in the present application will be briefly described as follows.
(1) It is possible to clarify the positional relationship between the light irradiation position and the light detection position arranged three-dimensionally and the topography image.
(2) It is possible to easily grasp the change amount and change region of the hemoglobin amount at the measurement site.
(3) The diagnostic efficiency can be improved.
[Brief description of the drawings]
FIG. 1 is a diagram for explaining a schematic configuration of a biological light measurement apparatus according to an embodiment of the present invention.
FIG. 2 is a diagram for explaining details of an operation of generating a biological-passage light intensity image by the processing unit of the present embodiment.
FIG. 3 is a diagram for explaining an operation of generating a biological-passage light intensity image according to the same processing procedure as in the prior art.
FIG. 4 is a diagram showing an example of a three-dimensional topography image displayed on the display unit of the present embodiment.
[Explanation of symbols]
DESCRIPTION OF SYMBOLS 1 ... Light source part, 2 ... Optical module, 3 ... Oscillating part, 8 ... Optical fiber for irradiation, 9 ... Measurement object, 10 ... Optical fiber for detection, 11 ... Photodiode, 12 ... Lock-in amplifier module, 16 ... A / D converter 17 ... control means, 18 ... recording means, 19 ... processing means, 20 ... display means, 21 ... three-dimensional position detection means, 201 ... three-dimensional position information related to head shape, 202 ... for irradiation and detection Three-dimensional position information related to the contact position between the optical fiber for measurement and the measurement target; 401, a wire frame image of the measurement target; 402, a region where the hemoglobin concentration change amount is small; 403, a region where the hemoglobin concentration change amount is large.

Claims (7)

Means for irradiating the subject with light from a plurality of light irradiation positions; and a plurality of detections in which light irradiated from the plurality of light irradiation positions and passed through the inside of the subject is installed in the vicinity of the plurality of light irradiation positions A biological light measurement apparatus comprising: a light detection unit that detects a position; and a signal processing unit that creates a topographic image representing the biological information inside the subject using a light amount at each detection position detected by the light detection unit. In
The signal processing means includes means for setting three-dimensional coordinate data representing a positional relationship between the light irradiation position and the light detection position and a reference point provided on the subject, and three-dimensional data based on the three-dimensional coordinate data. The three-dimensional topography is formed by combining a means for creating a topography image, the three-dimensional coordinate data indicating the positional relationship between the light irradiation position and the light detection position, and the three-dimensional coordinate data of the three-dimensional morphological image of the subject. A biological light measurement device comprising means for creating and displaying a composite image of an image and the morphological image . 2. The biological light measurement apparatus according to claim 1, wherein the signal processing means further includes means for arranging the three-dimensional topography image within a predetermined depth from the surface of the subject in the three-dimensional morphological image. A biological light measurement device characterized by that. 2. The biological light measurement apparatus according to claim 1, further comprising means for inputting three-dimensional morphological image data of the subject. 2. The biological light measurement apparatus according to claim 1, wherein the signal processing means includes means for creating a wire frame image of the subject as the morphological image. The biological light measurement apparatus according to claim 1, wherein the morphological image includes a tomographic image. The biological light measurement apparatus according to claim 5, wherein the morphological image includes a CT image. The biological light measurement apparatus according to claim 5, wherein the morphological image includes an MRI image.

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