JP4257515B2 - Process for producing 1,3-bis (3-aminopropyl) -1,1,3,3-tetramethyldisiloxane - Google Patents

Description

  The present invention relates to 1,3-bis (3-aminopropyl) -1,1,3, which is useful as a modifier for polyimide used in semiconductor insulating films, liquid crystal alignment films, and the like, and as a modifier for polyurethane and polyamide. The present invention relates to a method for producing 3-tetramethyldisiloxane.

  The following methods are known as methods for producing 1,3-bis (3-aminopropyl) -1,1,3,3-tetramethyldisiloxane. (1) A method of deprotecting an amino group-protected allylamine and tetramethyldisiloxane, followed by deprotection (Non-Patent Document 1: J. Org. Chem., 24, 119, (1959), Patent Document 1: Japanese Patent Publication No. 7-55953). (2) A method in which allylamine and dimethylalkoxysilane are subjected to a hydrosilylation reaction in the presence of a platinum catalyst having an olefin, a derivative thereof or a siloxane derivative as a ligand, and the resulting product is hydrolytically condensed (Patent Document 2: Japanese Patent Laid-Open 2-304094). (3) A method in which an allylamine having an amino group protected and dimethylalkoxysilane are subjected to a hydrosilylation reaction, followed by deprotection and hydrolysis condensation of the resulting product (Patent Document 3: JP-A-11-209385) ).

  However, in the method (1), an isomer added inside rather than at the end in the hydrosilylation reaction, that is, 1- (2-aminopropyl) -3- (3-aminopropyl) -1,1,3,3 -There is a problem that a large amount of tetramethyldisiloxane is produced and the purity is lowered. Also in the method (2), many isomers are added in the hydrosilylation reaction instead of at the end, and the purity is lowered as in (1). In addition, dimethylalkoxysilane is unstable and difficult to handle industrially. In the method (3), as in (2), unstable dimethylalkoxysilane must be used, which is problematic for industrial production.

Japanese Patent Publication No. 7-55953 Japanese Patent Laid-Open No. 2-304094 JP-A-11-209385 J. et al. Org. Chem. , 24, 119, (1959)

  The present invention has been made in view of the above circumstances, and is industrially effective as a high-quality 1,3-bis (3-aminopropyl) -1,1,3,3-tetramethyldisiloxane containing no isomer. An object is to provide a manufacturing method.

  As a result of intensive studies to achieve the above object, the present inventor has obtained N, N-bistrimethylsilylaminopropyl obtained by hydrosilylation reaction of N, N-bistrimethylsilylallylamine and dimethylchlorosilane in the presence of a platinum catalyst. Before reacting dimethylchlorosilane with an alcohol to give a 3-aminopropyldimethylalkoxysilane compound, followed by hydrolysis and condensation with water, or reacting N, N-bistrimethylsilylaminopropyldimethylchlorosilane with an alcohol, Reaction with ammonia yields 1,3-bis (N, N-bistrimethylsilylaminopropyl) -1,1,3,3-tetramethyldisilazane, which is reacted with alcohol to give 3-aminopropyldimethyl Alkoxysilane compound in water It was discovered that high-purity 1,3-bis (3-aminopropyl) -1,1,3,3-tetramethyldisiloxane containing no isomer can be produced in high yield by hydrolytic condensation, The present invention has been completed.

Accordingly, the present invention provides the following formula (1) obtained by reacting N, N-bistrimethylsilylallylamine and dimethylchlorosilane in the presence of a platinum catalyst.
[(CH ₃ ) ₃ Si] ₂ NCH ₂ CH ₂ CH ₂ Si (CH ₃ ) ₂ Cl (1)
1,3-bis (3, characterized by reacting N, N-bistrimethylsilylaminopropyldimethylchlorosilane represented by the following formula with alcohol and hydrolyzing and condensing the resulting 3-aminopropyldimethylalkoxysilane compound with water. -Aminopropyl) -1,1,3,3-tetramethyldisiloxane production method, and before the N, N-bistrimethylsilylaminopropyldimethylchlorosilane is reacted with alcohol, it is reacted with ammonia to produce the following formula (2 )
[{(CH ₃ ) ₃ Si} ₂ NCH ₂ CH ₂ CH ₂ Si (CH ₃ ) ₂ ] ₂ NH (2)
1,3-bis (N, N-bistrimethylsilylaminopropyl) -1,1,3,3-tetramethyldisilazane represented by the formula (3) was reacted with alcohol, and the resulting 3-aminopropyldimethylalkoxy was obtained. Provided is a method for producing 1,3-bis (3-aminopropyl) -1,1,3,3-tetramethyldisiloxane, characterized by hydrolytic condensation of a silane compound with water.

  According to the present invention, N, N-bistrimethylsilylaminopropyldimethylchlorosilane obtained by reacting N, N-bistrimethylsilylallylamine and dimethylchlorosilane in the presence of a platinum catalyst is used as a raw material, so that no isomer is contained. High purity 1,3-bis (3-aminopropyl) -1,1,3,3-tetramethyldisiloxane can be produced in high yield.

Hereinafter, the present invention will be described in more detail.
The method for producing 1,3-bis (3-aminopropyl) -1,1,3,3-tetramethyldisiloxane of the present invention comprises the following three reaction steps.

(I) Hydrosilylation step

(Ii) alkoxylation step

(Iii) Hydrolytic condensation step
(In the above formula, Me represents a methyl group.)

  In the hydrosilylation step, N, N-bistrimethylsilylallylamine and dimethylchlorosilane are reacted in the presence of a platinum catalyst to form N, N-bistrimethylsilylaminopropyldimethylchlorosilane.

  The blending ratio of N, N-bistrimethylsilylallylamine and dimethylchlorosilane used in the above reaction is not particularly limited. However, from the viewpoint of reactivity and productivity, 0. A range of 5-2 mol, particularly 0.8-1.2 mol is preferred.

  Specific examples of the platinum catalyst used in the above reaction include chloroplatinic acid, an alcohol solution of chloroplatinic acid, and toluene of platinum-1,3-divinyl-1,1,3,3-tetramethyldisiloxane complex. Alternatively, xylene solution, tetrakistriphenylphosphine platinum, dichlorobistriphenylphosphine platinum, dichlorobisacetonitrile platinum, dichlorobisbenzonitrile platinum, dichlorocyclooctadiene platinum and the like are exemplified.

  The amount of the platinum catalyst used is not particularly limited, but from the viewpoint of reactivity and productivity, 0.000001 to 0.01 mol, particularly 0.00001 to 0.001 mol, with respect to 1 mol of N, N-bistrimethylsilylallylamine. The range of is preferable.

  In the alkoxylation step, N, N-bistrimethylsilylaminopropyldimethylchlorosilane is alkoxylated with alcohol and the silicon-nitrogen bond is cleaved with alcohol to obtain a 3-aminopropyldimethylalkoxysilane compound.

  Here, as alcohol used, what is shown by ROH (R is a C1-C20, especially 1-10 alkyl group) is preferable, Specifically, methanol, ethanol, 1-propanol, 1-butanol, etc. However, methanol and ethanol are preferable from the viewpoint of reactivity and price.

  The blending ratio of alcohol and N, N-bistrimethylsilylaminopropyldimethylchlorosilane is not particularly limited, but from the viewpoint of reactivity and productivity, 2.5 moles of alcohol is used per mole of N, N-bistrimethylsilylaminopropyldimethylchlorosilane. A range of ˜20 mol, in particular 2.8 to 10 mol, is preferred.

  When N, N-bistrimethylsilylaminopropyldimethylchlorosilane is reacted with alcohol, it becomes a hydrochloride of 3-aminopropyldimethylalkoxysilane, so that a basic compound is added during or after the reaction, A free amine is preferred. Specific examples of the basic compound used include metal alkoxide compounds such as sodium methoxide and sodium ethoxide, sodium hydroxide and potassium hydroxide.

  The addition amount of the basic compound is not particularly limited, but a range of 0.5 to 2.0 mol, particularly 0.8 to 1.2 mol is preferable with respect to 1 mol of N, N-bistrimethylsilylaminopropyldimethylchlorosilane.

Further, without directly reacting N, N-bistrimethylsilylaminopropyldimethylchlorosilane and alcohol, first, N, N-bistrimethylsilylaminopropyldimethylchlorosilane is reacted with ammonia to obtain the following formula (2):
[{(CH ₃ ) ₃ Si} ₂ NCH ₂ CH ₂ CH ₂ Si (CH ₃ ) ₂ ] ₂ NH (2)
1,3-bis (N, N-bistrimethylsilylaminopropyl) -1,1,3,3-tetramethyldisilazane, and then reacted with alcohol to give a 3-aminopropyldimethylalkoxysilane compound. You can also.

  The amount of ammonia used is not particularly limited, but is preferably in the range of 1.0 to 3.0 mol, particularly 1.2 to 2.0 mol, with respect to 1 mol of N, N-bistrimethylsilylaminopropyldimethylchlorosilane.

  Ammonium chloride is formed after the reaction with ammonia, which can be removed by filtration or washing with water, and may proceed to the next step without being removed.

  The reaction with alcohol can be carried out in the same manner as in the case of direct reaction. However, unlike the above, at the end of the reaction, the hydrochloride of 3-aminopropyldimethylalkoxysilane is not in the form of a hydrochloride, so a step of making a free amine using a basic compound is not necessary.

  Next, in the hydrolysis condensation step, the 3-aminopropyldimethylalkoxysilane compound obtained in the alkoxylation step is converted to 1,3-bis (3-aminopropyl) -1,1,3,3 by hydrolysis condensation. -Tetramethyldisiloxane.

  In this case, it is possible to add water directly to the reaction solution after completion of the alkoxylation step, but it may be condensed with the trimethylalkoxysilane compound present in the reaction solution, resulting in a decrease in yield. It is better to carry out after removing the trimethylalkoxysilane compound remaining in the liquid by fractional distillation or the like.

  The amount of water to be added is not particularly limited, but is preferably 0.3 to 10 mol, particularly preferably 0.4 to 5 mol, relative to 1 mol of the 3-aminopropyldimethylalkoxysilane compound.

  The hydrosilylation reaction, alkoxylation reaction, hydrolysis condensation reaction, and further disilazane formation reaction proceed even without solvent, but a solvent can also be used. Solvents used include hydrocarbon solvents such as pentane, hexane, cyclohexane, heptane, isooctane, benzene, toluene and xylene, ether solvents such as diethyl ether, tetrahydrofuran and dioxane, and ester solvents such as ethyl acetate and butyl acetate. And aprotic polar solvents such as acetonitrile and N, N-dimethylformamide, and chlorinated hydrocarbon solvents such as dichloromethane and chloroform. These solvents may be used alone or in combination of two or more.

  The reaction temperature of the hydrosilylation reaction, alkoxylation reaction, hydrolysis condensation reaction, and further disilazane formation reaction is not particularly limited, but is preferably 0 to 150 ° C, particularly preferably 20 to 120 ° C. Although the reaction time is not particularly limited, it is preferably 1 to 15 hours, particularly 1 to 10 hours.

  EXAMPLES Hereinafter, although a synthesis example, an Example, and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example.

[Synthesis Example 1] Synthesis of N, N-bistrimethylsilylaminopropyldimethylchlorosilane In a flask equipped with a stirrer, reflux condenser, dropping funnel and thermometer, 201.5 g (1.0 mol) of N, N-bistrimethylsilylallylamine. Then, 0.65 g of a toluene solution of platinum-1,3-divinyl-1,1,3,3-tetramethyldisiloxane complex (platinum content 3% by mass) was charged and heated to 80 ° C. After the internal temperature was stabilized, 99.3 g (1.05 mol) of dimethylchlorosilane was added dropwise at 80 to 90 ° C. over 4 hours, followed by stirring at that temperature for 1 hour. The reaction solution was distilled to obtain 273.6 g of N, N-bistrimethylsilylaminopropyldimethylchlorosilane as a fraction having a boiling point of 74 to 75 ° C./0.13 kPa (yield 92%).

[Example 1]
A flask equipped with a stirrer, reflux condenser, dropping funnel and thermometer was charged with 296.1 g (1.0 mol) of N, N-bistrimethylsilylaminopropyldimethylchlorosilane, and 202.5 g of 28% sodium methoxide in methanol. Was added dropwise at 55 to 60 ° C. over 3 hours, and the mixture was stirred at that temperature for 1 hour. The resulting salt was filtered, trimethylmethoxysilane was removed by fractional distillation, 27 g of water was added and refluxed for 2 hours, and then the reaction solution was distilled. 102.2 g of 1,3-bis (3-aminopropyl) -1,1,3,3-tetramethyldisiloxane was obtained as a fraction having a boiling point of 81 to 82 ° C./0.13 kPa (yield 82%).
As a result of analyzing the obtained compound by gas chromatography, the isomer 1- (2-aminopropyl) -3- (3-aminopropyl) -1,1,3,3-tetramethyldisiloxane was completely It was confirmed that it was not generated.

[Example 2]
A flask equipped with a stirrer, a reflux condenser, a dropping funnel and a thermometer was charged with 296.1 g (1.0 mol) of N, N-bistrimethylsilylaminopropyldimethylchlorosilane and 28.1 g (1.7 mol) of ammonia in 20 parts. The mixture was fed at ˜30 ° C. over 3 hours and stirred at that temperature for 1 hour. The resulting salt was separated by filtration, the filtrate was again charged into the flask, 192.0 g (6.0 mol) of methanol was added dropwise at 50-60 ° C. over 1 hour, and then refluxed for 4 hours. Trimethylmethoxysilane was removed by fractional distillation, and 27 g of water was added and refluxed for 2 hours, and then the reaction solution was distilled. 100.3 g of 1,3-bis (3-aminopropyl) -1,1,3,3-tetramethyldisiloxane was obtained as a fraction having a boiling point of 81 to 82 ° C./0.13 kPa (yield 81%).
As a result of analyzing the obtained compound by gas chromatography, 1- (2-aminopropyl) -3- (3-aminopropyl) -1,1,3,3-tetramethyldisiloxane was not produced at all. It was confirmed.

[Example 3] Isolation of 1,3-bis (N, N-bistrimethylsilylaminopropyl) -1,1,3,3-tetramethyldisilazane A stirrer, reflux condenser, dropping funnel and thermometer were provided. The flask was charged with 118.4 g (0.4 mol) of N, N-bistrimethylsilylaminopropyldimethylchlorosilane and fed with 11.2 g (0.7 mol) of ammonia at 20-30 ° C. over 3 hours. Stir for 1 hour. 80 g of water was added, the resulting salt was dissolved, the aqueous layer was removed, and then the organic layer was distilled to obtain 92.7 g of a fraction having a boiling point of 160 to 165 ° C./27 Pa.
A mass spectrum, ¹ H-NMR spectrum, and IR spectrum of the obtained fraction were measured. The results of mass spectrum are shown below, and the results of NMR (deuterated chloroform solvent) and IR spectrum are shown in FIGS. From these results, it was confirmed that the obtained compound was 1,3-bis (N, N-bistrimethylsilylaminopropyl) -1,1,3,3-tetramethyldisilazane.
Mass spectrum m / z 535, 174, 146, 73

Example 4 1,3-bis (3-aminopropyl)-from isolated 1,3-bis (N, N-bistrimethylsilylaminopropyl) -1,1,3,3-tetramethyldisilazane Production of 1,1,3,3-tetramethyldisiloxane 1,3-bis (N, N-bis) obtained in Example 3 was placed in a flask equipped with a stirrer, reflux condenser, dropping funnel and thermometer. Trimethylsilylaminopropyl) -1,1,3,3-tetramethyldisilazane 80.3 g (0.15 mol) was charged, and 57.6 g (1.8 mol) of methanol was added dropwise at 50 to 60 ° C. over 1 hour. Thereafter, the mixture was refluxed for 4 hours. Trimethylmethoxysilane was removed by fractional distillation, 8.1 g of water was added and refluxed for 2 hours, and then the reaction solution was distilled. As a fraction having a boiling point of 81 to 82 ° C./0.13 kPa, 34.7 g of 1,3-bis (3-aminopropyl) -1,1,3,3-tetramethyldisiloxane was obtained (yield 93%).
As a result of analyzing the obtained compound by gas chromatography, 1- (2-aminopropyl) -3- (3-aminopropyl) -1,1,3,3-tetramethyldisiloxane was not produced at all. It was confirmed.

[Comparative Example 1]
A flask equipped with a stirrer, a reflux condenser, a dropping funnel and a thermometer was charged with 129.3 g (1.0 mol) of N-trimethylsilylallylamine, 0.98 g of 4% chloroplatinic acid in isopropyl alcohol, 6,3-tetramethyldisiloxane 67.2g (0.5mol) was dripped at 70-80 degreeC over 3 hours, and it stirred at the temperature for 1 hour. Thereafter, 64.0 g of methanol was added and refluxed for 1 hour to carry out a desilylation reaction.
As a result of analyzing the obtained reaction liquid by gas chromatography, 1- (2-aminopropyl) -3- (3-aminopropyl) -1,1,3,3-tetramethyldisiloxane, which is an isomer, was obtained. It was confirmed that the content was 7% with respect to the desired 1,3-bis (3-aminopropyl) -1,1,3,3-tetramethyldisiloxane.

^{1 is} a ¹ H-NMR spectrum of 1,3-bis (N, N-bistrimethylsilylaminopropyl) -1,1,3,3-tetramethyldisilazane. (Example 3) It is an IR spectrum of 1,3-bis (N, N-bistrimethylsilylaminopropyl) -1,1,3,3-tetramethyldisilazane. (Example 3)

Claims (2)

The following formula (1) obtained by reacting N, N-bistrimethylsilylallylamine and dimethylchlorosilane in the presence of a platinum catalyst
[(CH ₃ ) ₃ Si] ₂ NCH ₂ CH ₂ CH ₂ Si (CH ₃ ) ₂ Cl (1)
1,3-bis (3, characterized by reacting N, N-bistrimethylsilylaminopropyldimethylchlorosilane represented by the following formula with alcohol and hydrolyzing and condensing the resulting 3-aminopropyldimethylalkoxysilane compound with water. -Aminopropyl) -1,1,3,3-tetramethyldisiloxane production method. The following formula (1) obtained by reacting N, N-bistrimethylsilylallylamine and dimethylchlorosilane in the presence of a platinum catalyst
[(CH ₃ ) ₃ Si] ₂ NCH ₂ CH ₂ CH ₂ Si (CH ₃ ) ₂ Cl (1)
N, N-bistrimethylsilylaminopropyldimethylchlorosilane represented by the following formula (2)
[{(CH ₃ ) ₃ Si} ₂ NCH ₂ CH ₂ CH ₂ Si (CH ₃ ) ₂ ] ₂ NH (2)
1,3-bis (N, N-bistrimethylsilylaminopropyl) -1,1,3,3-tetramethyldisilazane represented by the formula (3) was reacted with alcohol, and the resulting 3-aminopropyldimethylalkoxy was obtained. A method for producing 1,3-bis (3-aminopropyl) -1,1,3,3-tetramethyldisiloxane, comprising hydrolyzing and condensing a silane compound with water.