JP4126374B2 - Composition for producing biological models such as blood vessel walls and internal organs - Google Patents

Description

  The present invention relates to a biological model that can be used for medical training and the like, a method for producing the biological model, and a composition for producing the biological model.

  Conventionally, biological models have been used for medical education training, surgical technique training, and the like. Conventionally, models made mainly of silicone resin have been used. In addition, there have been reports on a human body pseudo model (see Patent Document 1) mainly composed of polyurethane and a human body member model (see Patent Document 2) mainly composed of polyurethane and epoxy resin. These biological models have poor adhesion between models after molding, and even if models are produced for each part, it is difficult to combine them. In addition, adhesion with other materials was extremely poor, and processing after molding was difficult. In addition, the silicone resin is expensive, and the biological model cannot be supplied at a low cost. It is desirable that the living body model has the same properties as an actual organ or tissue of the living body in terms of flexibility, elasticity and the like when incising with a scalpel or the like. In the conventional living body model, the feel when incised is far from the actual living body. In addition, it is preferable that a variety of models can be produced by making each part and bonding it to other parts. In particular, a model of an internal organ that is incised at the time of surgery is necessary to give a touch (cutting edge) similar to that of actual surgery.

Japanese Unexamined Patent Publication No. 6-80758 Japanese National Patent Publication No. 11-503770

  An object of the present invention is to provide a living body model having flexibility and elasticity similar to those of animal blood vessels, internal organs, and the like.

  The inventors of the present invention have made extensive studies on the production of biological models that are similar to animal blood vessel walls and internal organs in terms of softness (hardness, flexibility) and elasticity, and can be arbitrarily molded by mixing the following compounds: Thus, the present inventors have succeeded in producing a composition for producing a living body model having flexibility and elasticity similar to those of animal blood vessels, internal organs, etc., and completed the present invention.

That is, the present invention is as follows.
[1] A composition for producing a biological model comprising the following components (1) to (3):
(1) (a) A homopolymer of vinyl acetate or a partial hydrolyzate thereof, or vinyl acetate and acrylic acid ester, acrylic acid amide, acrylic acid, methacrylic acid, methacrylic acid ester, maleic acid, maleic anhydride, and fumar A polymer component comprising a copolymer of one or more monomers selected from the group consisting of acids or a partial hydrolyzate thereof, and (b) one or a group selected from the group consisting of sap, fruit juice, nectar, honey and sugar A composition comprising a compound comprising a component comprising two or more,
(2) Gelatin, or agar or agarose, and (3) A compound mainly composed of acrylic resin
[2] The composition of [1] further comprising a colorant,
[3] The composition of [1] or [2], wherein component (1) (b) is birch sap,
[4] The composition according to any one of [1] to [3], wherein 20 g of a mixture obtained by mixing component (1) and component (2) at a volume ratio of 3: 0.5 to 2 contains 0.1 to 1 g of component (3) ,
[5] The composition according to any one of [1] to [4], wherein the biological model is a blood vessel wall or a visceral organ,
[6] A method for producing a biological model including mixing, molding and drying the following components (1) to (3):
(1) (a) A homopolymer of vinyl acetate or a partial hydrolyzate thereof, or vinyl acetate and acrylic acid ester, acrylic acid amide, acrylic acid, methacrylic acid, methacrylic acid ester, maleic acid, maleic anhydride, and fumar A polymer component comprising a copolymer of one or more monomers selected from the group consisting of acids or a partial hydrolyzate thereof, and (b) one or a group selected from the group consisting of sap, fruit juice, nectar, honey and sugar A composition comprising a compound comprising a component comprising two or more,
(2) Gelatin, or agar or agarose, and (3) A compound mainly composed of acrylic resin
[7] The method for producing a biological model according to [6], further comprising mixing a colorant,
[8] A method for producing a biological model according to [6] or [7], wherein (b) of component (1) is birch sap,
[9] Any of [6] to [8], comprising mixing 0.1 to 1 g of component (3) with 20 g of a mixture in which component (1) and component (2) are mixed at a volume ratio of 3: 0.5-2. A method for producing such a biological model,
[10] The method for producing a biological model according to any one of [6] to [9], wherein the biological model is a blood vessel wall or a visceral organ.
[11] A method for producing a biological model of a blood vessel wall, comprising molding the composition according to any one of [1] to [5] into a film shape and drying the composition,
[12] A method for producing a visceral living body model, comprising molding the composition according to any one of [1] to [5] into a visceral mold and drying the composition;
[13] A method for producing a biological model, comprising molding the composition according to any one of [1] to [5] and combining it with another biological model, and
[14] A biological model produced by the method according to any one of [7] to [13].

  By using the composition of the present invention, the appearance such as color and texture, softness, elasticity, and other characteristics are very similar to animal blood vessel walls, internal organs, etc. A similar biological model can be created. The biological model of the present invention can be used for medical student education, surgical technique training, surgical rehearsal, and the like, and can also be used as an explanatory model for informed consent between doctors and patients. Furthermore, it can also be used for the development of surgical instruments such as scalpels, tweezers and forceps.

Hereinafter, the present invention will be described in detail.
The composition for producing a biological model of the present invention is a polymer composition containing the following (1) to (3).

(1) is component (a) homopolymer of vinyl acetate or a partial hydrolyzate thereof, or vinyl acetate and acrylic acid ester, acrylic acid amide, acrylic acid, methacrylic acid, methacrylic acid ester, maleic acid, maleic anhydride, And a polymer component comprising a copolymer with one or more monomers selected from the group consisting of fumaric acid or a partial hydrolyzate thereof, and (b) selected from the group consisting of sap, fruit juice, nectar, honey and sugars It is a composition containing the compound containing the component containing 1 type, or 2 or more types.
(2) Gelatin or agar or agarose (3) A compound mainly composed of acrylic resin,
Further, the composition of the present invention may contain a cellulose-based powder mainly composed of cellulose or a starch-based powder mainly composed of starch. Further, a coloring agent such as a dye or a pigment may be contained, and the coloring agent is not limited, and examples thereof include acrylic paints. Examples of acrylic paints include Delta Ceramcoat (registered trademark) (Delta Technical Coating, Inc. Manufactured).

  A good composition can be obtained by mixing these components. If necessary, water may be added.

Homopolymer of vinyl acetate of component (1) or a partial hydrolyzate thereof, or vinyl acetate and acrylic acid ester, acrylic acid amide, acrylic acid, methacrylic acid, methacrylic acid ester, maleic acid, maleic anhydride, and fumaric acid The polymer component containing a copolymer with one or two or more monomers selected from the group consisting of or a partial hydrolyzate thereof is preferably in an emulsion state. In this sense, component (a) in component (1) of the present invention is an aqueous latex emulsion. Here, latex refers to an aqueous dispersion containing polymer or copolymer molecules.

Emulsions containing vinyl acetate homopolymers or copolymers are commercially available. For example, the following product groups sold at handicraft stores can be applied. `` Bond for woodwork (made by Konishi Co., Ltd., adhesive) '', `` Moto Podge (made by PLAID, finishing agent) '', `` Porea (made by PLAID, finishing agent) '', `` Shine finish (Janty Co., Ltd.) Made, finishing agent) "," Halgross (Hull Enterprise, finishing agent) ",
“Clear Poggi (American Handicraft Co., Finishing Agent)”, “Top Coat Gloss (Janty Co., Ltd. Finishing Agent)”, Trade Name “Transfer Coat (Jantee Co., Ltd., Transfer Solution)”, “Hull Transfer ( Halen Couprice, transfer solution)
, “San finishe (manufactured by Sanyu Co., Ltd., finishing agent)” and the like. Accordingly, the material of the present invention can include one or more of these commercially available products. Of these, MOTOPOSY is preferably used, and PLAID catalog ITEM # CS11222, CS11221, CS11220, CS11219, CS11218, CS11217, CS11213, CS11211, CS11201, CS11202, CS11203, CS11204, CS11205, CS11207, CS11301, CS11302, CS11303, etc. The following motoposi may be used. Further, latex emulsions described in US Pat. No. 3,616,005 can also be suitably used.

  The vinyl acetate homopolymer used in the present invention is a conventionally known method in which a vinyl acetate monomer is appropriately diluted with an emulsifier, a polymerization initiator, a catalyst, a protective stabilizer, a plasticizer, and various additives, and mixed. It can be easily obtained by emulsion polymerization.

  A vinyl acetate copolymer is prepared by mixing a vinyl acetate monomer and a monomer (comonomer) to be copolymerized therewith, selecting an emulsifier, a polymerization initiator, a catalyst, a protective stabilizer, a plasticizer, and various additives as appropriate. Thus, it can be easily obtained by emulsion polymerization by a conventionally known method. In this case, one or more monomers selected from acrylic ester, acrylic amide, acrylic acid, methacrylic acid, methacrylic ester, maleic acid, maleic anhydride, and fumaric acid can be used as a comonomer. Is mentioned. Among these, the preferred comonomer is an acrylate ester, an acrylate amide, judging from the viewpoint of the function that the obtained composition can be easily shaped, processed and molded into an arbitrary shape and the flexibility, viscosity and elasticity can be adjusted. One or more monomers selected from the group consisting of acrylic acid, methacrylic acid, methacrylic acid ester, maleic acid, maleic anhydride and fumaric acid. More preferred comonomers include one or more monomers selected from the group consisting of acrylic acid esters, acrylic acid amides, acrylic acid, methacrylic acid, methacrylic acid esters, maleic acid, and maleic anhydride. Particularly preferred comonomers include one or more monomers selected from the group consisting of acrylic acid esters, acrylic acid amides, acrylic acid, methacrylic acid, and methacrylic acid esters.

In addition, the component (a) may itself contain moisture, for example, an aqueous latex containing a non-volatile component, a vinyl acetate as a main component, and a copolymer containing a plasticizer or stabilizer such as dibutyl phthalate. It can be illustrated. Examples of such an aqueous latex include a non-volatile component, a copolymer containing vinyl acetate as a main component and acrylate as a minor component, and further mixed with dibutyl phthalate.

  “Sap” means a liquid component of a plant body, and sap of pine, white birch, maple, sugar millet, sugar beet is preferable. Sap obtained from these plants can be used alone, or a mixture of two or more can be used. As the sap, one that naturally flows out from the surface of the plant body can be used, and one extracted from the plant body by various methods can also be used. For example, the surface of a tree such as a white birch can be used to leak sap, and a tube of an appropriate thickness is inserted into a trunk such as a white birch, and the liquid flowing through the plant body is collected and used. You can also. Further, the sap thus obtained may be used after, for example, filtering to remove solid components. As long as a part of the components of the sap is included, it is included in the “sap” of the present invention. For example, commercially available birch sap may be used. Examples of the components of birch sap include fructose, glucose, amino acids, malic acid, polysaccharides (Kirelan), saccharides (syringarezinol), and other minerals. An artificial liquid prepared by artificially mixing the main components of the sap is also included in the “sap” of the present invention. The components of the birch sap are exemplary, and may vary depending on the region, season, and the like.

  “Fruit” refers to the liquid components of plant fruits, including butter, peach, citrus, apple, banana, watermelon, melon, cherry, pear, pineapple, palm, papaya, mango, and durian. Can be used. The liquid component of these fruits can also be used independently, and what mixed 2 or more types can also be used. The fruit liquid can be obtained from the fruit by a mixer treatment or the like. The fruit liquid thus obtained may be used after, for example, filtering to remove solid components. As long as a part of the components of the fruit juice is contained, it is included in the “fruit juice” of the present invention.

  “Honey” means that the bees sucked the nectar, which is a polysaccharide, from the nectar of the flower of the plant into the stomach (honeycomb), spit it while breaking down into monosaccharides, and stored it in the nest . What contains 1 type or 2 or more types obtained from astragalus, tochi, and acacia can be used.

  The above sap, fruit liquid, and honey contain water (for example, white birch sap contains about 90 to about 95% water, and finally depends on the water content to be included in the material composition of the present invention. And can be diluted with water as appropriate, or may be concentrated to reduce the water content.

  “Saccharides” include monosaccharides, disaccharides and polysaccharides, and examples thereof include xylitol, sucrose, fructose, glucose, chitosan, chitin, mannan and guar gum. These sugars can be used alone, or a mixture of two or more can be used.

  As the component (1) of the material composition of the present invention, for example, a film-forming emulsion composition described in International Publication WO02 / 24801 can be used. This film-forming emulsion composition has the component composition described in International Publication No. WO02 / 24801, and can be prepared according to the description in the publication.

  As the gelatin, either acid-treated gelatin or alkali-treated gelatin can be used. Further, the origin is not limited, and gelatin derived from any mammals such as cattle and pigs and fish can be used.

Agar is a substance mainly composed of agarose extracted from seaweed. Things can be used. Moreover, you may use agarose which is a main component of agar.

  The acrylic resin refers to an acrylic ester polymer, a methacrylic ester polymer, or a copolymer resin thereof, and further includes a copolymer such as acrylonitrile, acrylamide, and N-methylolacrylamide in the present invention. In addition, component (3) of the composition of the present invention is a compound containing an acrylic resin as a main component, and the acrylic resin is 60% or more by weight%, preferably 70% or more, more preferably 80% or more, particularly preferably. Is a compound containing 90% or more, most preferably 95% or more. Moreover, an emulsion may be sufficient. As the component (3) of the present invention, for example, in an acrylic painting using an acrylic paint, a medium used to assist the characteristics of the acrylic paint can be used. Examples of the medium include gesso, modeling paste, gloss polymer medium, matte medium, gel medium, and matte burnish, and any of them can be used. Examples of the medium include “JO SONJA ’S (registered trademark) STROKE & BLENDING MEDIUM” and “JO SONJA ’S (registered trademark) MAGIC MIX” of CHROMA INC. (LITITA, PA 17543 USA, USA).

  Cellulose-based powder is a powder mainly composed of cellulose, and is obtained by finely pulverizing cellulose of wood or plant by chemical and mechanical treatment. Without limitation, commercially available cellulose powder, processed paper to powder, dried azuki bean skin to powder, beet pulp dried to powder, white birch What dried the leaf and processed it into powder, what processed the onion skin into powder, etc. can be used. The starch-based powder is a powder containing starch as a main component, and is not limited, and wheat flour, upper fresh flour, corn starch, potato starch and the like can be used.

  The composition for producing a living body model of the present invention can be used for making a living body model such as animal skin, perichondrium, mucous membrane, periosteum or the like, which is not limited, but has certain softness and elasticity. Each model has different flexibility and elasticity, and the composition can be changed according to the model. For example, the softness is reduced by adding powder. When cellulose-based powder is added among the above powders, a mucosal model excluding the nasal mucosa can be produced, and when starch-based powder is added, a skin model can be produced. Moreover, in order to reproduce the color of an actual living body, a colorant may be appropriately mixed with the components (1), (2) and (3).

  By changing the blending ratio of the above components, a biological model having arbitrary flexibility and elasticity can be produced, and the cutting and the like with a surgical instrument such as a scalpel can be adjusted.

Furthermore, the composition of the present invention may contain a material for imparting mechanical, electromagnetic properties, and X-ray properties. Examples of such a material include metal powder such as lead powder. Moreover, the fragrance | flavor etc. may be included.

  Further, when creating a biological model having a complicated structure, it is necessary to create a model for each part and then bond the parts together. Moreover, when fixing the produced part in a suitable position, it may be necessary to adhere | attach with other raw materials, such as an adhesive tape. Furthermore, it may be necessary to process or modify the shape after molding the human body model. The composition of the present invention can meet these needs because it has appropriate softness and elasticity.

2. Production method of the composition of the present invention The composition of the present invention can be produced by mixing the above-mentioned components at a certain ratio.
The polymer composition containing the components (a) and (b) of (1) can be produced by further mixing water with (a) and (b). For example, the mixing ratio of the component (a), the component (b), and water can be appropriately determined and changed depending on the biological model to be prepared, and is, for example, 1 to 4: 1: 1 to 4 by volume ratio. , Preferably 1-3: 1: 1-3, more preferably 2: 1: 2.

At this time, the composition of component (a) is not limited as long as it has the above-mentioned composition. For example, the non-volatile component of 55% by weight of polyvinyl acetate aqueous latex and dibutyl phthalate is 80 to 95% and 5%, respectively. Examples include compositions containing -20%, preferably 85-95% and 5-15%, more preferably 90-95% and 5-10%. More specifically, 92.5% by weight aqueous latex of polyvinyl acetate with 55% non-volatile content and 7.5% dibutyl phthalate
Examples thereof include a composition containing% by weight.

The component (2) gelatin preferably has a purity of 70% or more. A solution of such gelatin with a concentration of 1 to 10%, preferably 3 to 7% (W / V) is added to (1). The volume ratio at this time is 0.5 to 2, preferably 0.75 to 1.25, particularly preferably 1 for the gelatin solution with respect to component (1) of 3. As agar, commercially available dry agar may be returned to water and used. A commercially available agarose may be used. The mixing ratio of agar or agarose may be the same as that of gelatin.

When a colorant is added, an appropriate amount of colorant may be added so that the composition can be colored as desired. For example, when the colorant is a commercially available acrylic paint, for example, Delta Ceramcoat (registered trademark) (manufactured by Delta Technical Coating, Inc.), the above components (1), (2
) And (3) to mixture 4, 0.5 to 2, preferably 0.75 to 1.25, particularly preferably 1.

The component (3) based on an acrylic resin is used in an amount of 0.1 to 1 g, preferably 0.25 to 0.75, in 20 g of a mixture of components (1) and (2) or a mixture of components (1), (2) and a colorant. g, more preferably 0.4 to 0.6 g, particularly preferably 0.5 g may be added.

When adding powder, 0.1 to 1 g of powder is added to 10 g of the mixture of components (1), (2) and (3), or the mixture of components (1), (2), (3) and colorant. Preferably, 0.25 to 0.75 g, more preferably 0.4 to 0.6 g, and particularly preferably 0.5 g may be added.

  The composition of the present invention before and after drying can be evaluated by, for example, a tactile or visual sensory test. In the present specification, the result of the sensory test is referred to as a sensory characteristic. For example, several panels (people who evaluate by tactile sensation) are touched with the composition of the present invention, and their softness, elasticity, etc. are prepared according to a certain standard (for example, standard compositions having different softness and elasticity are prepared. It is possible to make a judgment by making a step evaluation by comparing with that). In addition, a dedicated measuring instrument for measuring flexibility, elasticity, and the like may be used.

3. Production of biological model The biological model of the present invention can be produced from the composition for producing a biological model produced as described above. A vascular wall living body model can be obtained by pouring the above composition into a container of an appropriate size so as to have a thickness of several mm and drying. At this time, since the composition after drying contracts compared with that before drying, it is necessary to pour the composition so as to have a thickness larger than the thickness of the desired biological model. Depending on the composition and moisture content of the composition, after drying, the thickness is reduced from 1/3 to 1/10, typically from 1/4 to 1/7, more typically to 1/6 before drying. For example, when a mucosal model having a thickness of 1 mm is prepared, the composition is poured into a thickness of 2 to 10 mm, preferably 4 to 7 mm, more preferably 6 mm, and dried. What is necessary is just to change thickness suitably according to the blood vessel to produce. A blood vessel model can be produced by making the blood vessel wall model formed into a film in this way into a cylindrical shape.

  Moreover, a visceral model can also be produced using the composition of the present invention. The internal organs are not limited, and the brain, heart, liver, pancreas, spleen, kidney, bladder, lung, stomach, small intestine, large intestine, uterus and the like can be produced. Since the softness and elasticity differ depending on the internal organs, the mixing ratio of each component of the composition may be appropriately changed according to the internal organs to be produced. The visceral model can be produced by pouring the composition of the present invention into a visceral mold separately produced with gypsum or the like and drying it by air drying for several hours to several days.

  By combining the model of the present invention with other biological models such as muscular tissue, bone tissue, and cartilage tissue that are separately prepared after drying, an animal biological model close to the real one can be prepared.

Furthermore, an image of an actual living body may be printed on the surface of the molded living body model.
Further, a sponge-like or gel-like material may be impregnated with the composition of the present invention in a liquid state before drying. By such a method, a model reproducing a tissue such as cartilage or a diseased site such as polyp or pus can be prepared. At this time, the sponge-like material impregnated with the composition of the present invention is not limited, and examples thereof include a melamine resin foam and a natural rubber porous puff. In this case, the above components (1) and (2) may be mixed, and a colorant and / or powder may be added as necessary. That is, the present invention relates to a cartilage model and a polyp model produced by impregnating a sponge-like material with a composition containing the component (1) and the component (2) and optionally containing a colorant and / or powder. Is also included.

  The produced biological model can be evaluated by, for example, a tactile sense or a visual sensory test. It can be evaluated by comparing the actual living body with characteristics such as flexibility and elasticity. At this time, from the viewpoint of a living body model that can be used for surgery, the ease of handling when using an instrument used for surgery may be compared with that of an actual living body. Examples of instruments used for surgery include tweezers, forceps (sharp forceps), scissor forceps, and the like. When touching with tweezers to make a hole (tweezers test), when tweezers are pulled (feeling) It can be evaluated by a touch (punch test) when a hole is cut with a punch-like surgical instrument such as a forceps test and a removal forceps.

  Furthermore, the composition of the present invention can be used for a sample model such as a food made of a biological material, and the food sample model is similar to a real food not only in shape but also in touch and stickiness. Under the present circumstances, the food sample model which aroma resembles the real thing can be produced by adding the fragrance | flavor which exhibits the aroma of a foodstuff to the composition of this invention.

  The present invention will be specifically described by the following examples, but the present invention is not limited to these examples.

[Example 1] Preparation of blood vessel model Ingredient (1) is mixed with Motoposi (MOD PODGE GROSS, catalog number Item # CS11201 manufactured by PLAID), birch sap and water in a volume ratio of 4: 1: 2 or 2: 1: 2. It was produced by mixing at a volume ratio of The birch sap was collected by making a hole in the trunk and attaching a pipe to the hole before the young birch leaves in April sprouted.

As a component (2), a gelatin solution prepared by dissolving 2.5 g of gelatin powder (Cook gelatin (manufactured by Morinaga Seika Co., Ltd.)) in water and making up to 50 ml was used. In addition, JO SONJA'S (registered trademark) MAGIC MIX (manufactured by CHROMA INC.) Was used as the component (3) a compound mainly composed of an acrylic resin. Component (1), component (2) and component (3) were mixed at a volume ratio of 3: 1: 1. 0.5 ml of the mixture was dropped onto the coated paper and dried into a film. The dried film was wrapped around a thin wooden rod with a diameter of about 1 mm coated with silicon wax, and bonded by pressing the ends together to form a cylindrical model. A photograph of the blood vessel model is shown in FIG.

[Example 2] Preparation of a visceral model Ingredient (1) is a motoposi (MOD PODGE GROSS, catalog number Item # CS11201 manufactured by PLAID), birch sap and water in a volume ratio of 4: 1: 2 or 2: 1: 2. It was produced by mixing at a volume ratio of The birch sap was collected by making a hole in the trunk and attaching a pipe to the hole before the young birch leaves in April sprouted.

As a component (2), a gelatin solution prepared by dissolving 2.5 g of gelatin powder (Cook gelatin (manufactured by Morinaga Seika Co., Ltd.)) in water and making up to 50 ml was used. In addition, JO SONJA'S (registered trademark) MAGIC MIX (manufactured by CHROMA INC.) Was used as the component (3) a compound mainly composed of an acrylic resin. Component (1), component (2) and component (3) were mixed at a volume ratio of 3: 1: 1.

  The composition was poured into a separately produced female kidney (half of each kidney), dried, and then bonded together. Furthermore, the kidney image separately photographed on the model is transferred to a sheet-shaped emulsion-forming emulsion composition described in WO02 / 24801, and the image is pasted on the kidney model to produce a kidney model did. The model was softened by heating to about 40 ° C., and the feeling when pressed was very similar to that of an actual kidney.

  FIG. 2 shows a photograph of a female kidney in which the composition of the present invention has been poured, and FIGS. 3 and 4 show photographs of a kidney model. FIG. 4 shows the model deformed to show the softness of the model.

It is a photograph of a blood vessel model. It is the photograph of the female type | mold of the kidney which poured the composition of this invention. It is a photograph of a kidney model. It is a photograph of a deformed kidney model.

Claims (14)

A composition for preparing a biological model comprising the following components (1) to (3).
(1) (a) A homopolymer of vinyl acetate or a partial hydrolyzate thereof, or vinyl acetate and acrylic acid ester, acrylic acid amide, acrylic acid, methacrylic acid, methacrylic acid ester, maleic acid, maleic anhydride, and fumar A polymer component comprising a copolymer of one or more monomers selected from the group consisting of acids or a partial hydrolyzate thereof, and (b) one or a group selected from the group consisting of sap, fruit juice, nectar, honey and sugar A composition comprising a compound comprising a component comprising two or more,
(2) Gelatin, or agar or agarose, and (3) A compound mainly composed of acrylic resin   The composition of claim 1 further comprising a colorant.   The composition according to claim 1 or 2, wherein (b) of component (1) is birch sap.   The composition according to any one of claims 1 to 3, wherein 0.1 to 1 g of component (3) is contained in 20 g of a mixture obtained by mixing component (1) and component (2) at a volume ratio of 3: 0.5 to 2.   The composition according to any one of claims 1 to 4, wherein the biological model is a blood vessel wall or a viscera. A method for producing a living body model, comprising mixing, molding and drying the following components (1) to (3).
(1) (a) A homopolymer of vinyl acetate or a partial hydrolyzate thereof, or vinyl acetate and acrylic acid ester, acrylic acid amide, acrylic acid, methacrylic acid, methacrylic acid ester, maleic acid, maleic anhydride, and fumar A polymer component comprising a copolymer of one or more monomers selected from the group consisting of acids or a partial hydrolyzate thereof, and (b) one or a group selected from the group consisting of sap, fruit juice, nectar, honey and sugar A composition comprising a compound comprising a component comprising two or more,
(2) Gelatin, or agar or agarose, and (3) A compound mainly composed of acrylic resin   Furthermore, the manufacturing method of the biological model of Claim 6 including mixing a coloring agent. The method for producing a biological model according to claim 6 or 7, wherein component (1) (b) is birch sap.   9. The method according to claim 6, comprising mixing 0.1 to 1 g of component (3) with 20 g of a mixture of component (1) and component (2) mixed at a volume ratio of 3: 0.5-2. A method for producing a living body model.   The method for producing a biological model according to any one of claims 6 to 9, wherein the biological model is a blood vessel wall or a viscera.   A method for producing a vascular wall living body model, comprising molding the composition according to any one of claims 1 to 5 into a film shape and drying it.   A method for producing a visceral biological model, comprising: putting the composition according to any one of claims 1 to 5 into a visceral mold, and drying the composition.   A method for producing a biological model, comprising molding the composition according to any one of claims 1 to 5 and combining the composition with another biological model.   A biological model produced by the method according to any one of claims 6 to 13.

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