JP4090018B2 - Functional micropile and manufacturing method thereof - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
The present invention provides a functional micropile that is a jig for providing a modification effect and / or functional effect in a skin surface layer and / or skin stratum corneum simply, safely and efficiently, and further, the functional micropile of the functional micropile. It relates to a manufacturing method.
[0002]
[Prior art]
Conventionally, as a technique for imparting a modification effect or a functional effect to the surface of a living body, that is, skin, mucous membrane, etc., most of them have been mainly applying a liquid substance or a powder cake. Since the target of the function was limited to the surface of the living body, the function disappeared due to perspiration, washing, unintentional foreign object contact, weather conditions, etc., and daily function regeneration was necessary. In addition, since the function reproducibility is limited due to manual labor, it is understood that the function regeneration act is inferior in all of convenience, safety and efficiency. In addition, in a solution intended to penetrate deep into the skin, it depends on a penetration phenomenon such as diffusion, and thus it can be said that it is difficult to reliably control the penetration depth.
[0003]
[Problems to be solved by the invention]
Convenience, safety, and efficiency in the above-mentioned function regeneration act are important issues.For example, in daily life, the action to deal with skin keratin degeneration is not limited to the time and effort spent on imparting functions to the skin. Extremely difficult. Attempts to erase skin alterations chemically or nutritionally are being carried out in various ways, but alteration itself is a representation of a complex biological phenomenon, and it is a problem related to the progress of aging. It is a permanent problem for everyday life.
[0004]
[Means for Solving the Problems]
The purpose of this patent is to chemically improve or physically obscure altered or discolored areas of the skin so that they are not visually perceived. Therefore, as a result of intensive research and development by the present inventors, a fine functional micropile was invented, and thus, in the skin surface layer and / or skin stratum corneum, which has been considered difficult in the past, under painless conditions, It succeeded in providing a modification effect and / or a functional effect simply, safely and efficiently. Furthermore, an efficient manufacturing method of the functional micropile has been invented, and the industrial production of the functional micropile has not been achieved.
[0005]
In the function enforcement action on the skin using the above micropile, the functional substance is limited to the skin stratum corneum by lightly pressing the micro or nano-sized functional pile mixed with the functional substance such as powder cake on the skin. When it is left under painless conditions, it can remain stably during skin keratin replacement by skin metabolism, that is, for 1 week to 10 days. Thereby, it is not necessary to re-execute the skin function again every day, and convenience can be provided in daily life. Next, by making the constituent material of the micropile sugar, even if the micropile remains in the skin stratum corneum or accidentally inserted too deeply into the blood vessel, the sugar micropile dissolves immediately. So it is extremely safe. Furthermore, by designing the structure of the functional micropile in various ways, it can sufficiently remain in the skin stratum corneum under painless conditions, and by using a plurality of micropile structures. It is possible to control the residual amount of functional substance even with a single skin inoculation, and therefore the efficiency is sufficiently improved.
[0006]
In the field of micromachines, process technology capable of high-precision machining of μm size or less has already been established. In the present invention, this technology is applied to realize a skin insertion jig mechanism of nm to μm size. I was able to. Therefore, it is possible to create a basic physical mechanism such as cutting, pinching, penetrating, holding, etc., and to act on the skin stratum corneum with high accuracy and ease. . In particular, in the present invention, the microfabrication technology disclosed in Japanese Patent Application No. 2000-347103 (Title of Invention: “Method and apparatus for processing material using X-ray”) is further developed to generate a pole generated from a synchrotron. The application of short-wavelength X-rays facilitates high-precision processing of nm size.
[0007]
That is, to summarize the present invention, the gist is
(1) It has a square or circular cross-sectional shape with a side or diameter of 0.1 to 100 μm and a structure in which a square columnar or columnar pile with a length of 0.5 to 500 μm is provided on a substrate, A functional micropile characterized by
(2) A rectangular or elliptical cross-sectional shape having a short side or short diameter of 0.1 to 100 μm and a pile having a rectangular column shape or elliptic column shape having a length of 0.5 to 500 μm was provided on the substrate. A functional micropile characterized by having a structure; and
(3) The functional micropile according to (1) or (2) above, wherein the main component material is a prismatic or columnar pile made of a saccharide that dissolves and disappears in vivo, and
(4) providing a path to reach the skin stratum corneum by bringing the micropile containing and / or containing the functional substance into contact with the skin, and inserting the functional substance into the stratum corneum. The above-described functional micropile (1) to (3), and
(5) The functional micropile according to the above (2) to (4), which can control the direction of folding by making it a rectangular or elliptical cross-sectional shape, and
(6) Functionality of the above (1) to (5), characterized in that a constricted portion is provided in the intermediate portion of the micropile, and it is easily folded at the constricted portion and only the micropile tip portion remains in the skin stratum corneum. Micropile, and
(7) The above-mentioned (1), characterized in that a step is provided in the middle part of the micropile by dividing it into a thin upper pile and a thick lower pile, and it is easily folded at the step part and only the upper pile remains in the skin stratum corneum. ) To (5) functional micropile, and
(8) The functional micropile according to (1) to (7) above, wherein the tip of the micropile has a knife shape and can be easily inserted into the skin stratum corneum, and
(9) The functional micropile according to (1) to (8) above, which has a structure in which a microcontainer enclosing a functional substance is provided inside the micropile, and
(10) An arrowhead-shaped portion is provided at the tip of the micropile, and the microcontainer is provided in the arrowhead-shaped portion. When the microcontainer is pulled out after contact with the skin, it is easily broken at the arrowhead-shaped portion by the return needle effect, and only the microcontainer is skin (9) the functional micropile characterized by remaining in the stratum corneum, and
(11) The functional micro of the above (1) to (8), which has a structure in which a capillary cavity is provided along the central axis of the micropile, and a functional substance can be included in the cavity. Pile, and
(12) The above-mentioned (1) to (11), wherein the functional stratum corneum has a structure capable of controlling the residual amount of the functional substance by disposing a plurality of functional micropiles on the substrate. ) Functional multi-micropile, and
(13) In the X-ray exposure when micro-processing the micro-pile, a columnar anti-reflection table larger than the micro-pile bottom area is provided in order to prevent the micro-pile bottom surface overexposure phenomenon caused by the reflected light from the substrate surface. (1) to (12) functional micropile characterized by having a structure, and
(14) The manufacturing process of the functional micropile according to (1) to (13) above,
(A) an X-ray lithography process for forming a micropile pattern by irradiating an X-ray photosensitive resin with synchrotron radiation X-rays;
(B) A mold manufacturing process for producing a micropile mold by electroforming a reversed shape of a micropile pattern;
(C) an injection molding process for forming a functional micropile by injection molding a functional material-containing material based on a micropile mold;
(D) Exterior assembly process for commercialization of functional micropile,
A manufacturing method of a functional micropile characterized by comprising the manufacturing steps of:
(15) The method for producing a functional micropile according to (14) above, wherein the X-ray photosensitive resin is a resin containing polymethyl methacrylate (PMMA).
[0008]
DETAILED DESCRIPTION OF THE INVENTION
Hereinafter, embodiments of the functional micropile in the present invention will be described, but the present invention is not limited to the following embodiments.
[0009]
This functional micropile provides a high-precision technique for inserting functional powder into the skin stratum corneum. In order to sufficiently provide the target functional substance, it is used as a substrate provided with a number of micropiles. For example, a functional substance mixed in a micropile can be inserted into the skin corneum by stamping on a 1 cm square substrate so that 10,000 or more functional micropiles are tapped on the skin. It is preferable that the predetermined function is exerted on the skin keratin.
The shape of the single micropile is not particularly limited, but a square column shape, a rectangular column shape, a columnar shape, an elliptical column shape, a conical shape thereof, or the like is preferable.
[0010]
When performing the intended function enforcement action, although it does not specifically limit, It is preferable to carry out by adding a functional substance only to the front-end | tip of a functional micropile.
[0011]
As another example, although not particularly limited, a multi-functional micropile arranged on a simple tape is provided. It is preferable to perform the intended function enforcement action by sticking the functional micropile toward the skin.
[0012]
The material of the functional micropile and microcontainer used in the present invention is not particularly limited, but it is preferable to use a sugar material that has already been put into practical use, such as maltose, as the main component material.
[0013]
The surface of the saccharide functional micropile used in the present invention is not particularly limited, but it may be water-repellent so as to avoid moisture permeation, and a structure capable of preventing softening due to moisture in the atmosphere is preferable.
[0014]
The functional substance to be mixed in the functional micropile used in the present invention is not particularly limited, but is preferably a water-soluble powder cake, and a functional powder powder already performed such as barium sulfate used for medical purposes. It is preferable to use it.
[0015]
Although the usage object of the functional micropile used by this invention is not specifically limited, The part of the opposite surface, such as a face and a limb, is preferable.
[0016]
The substrate of the functional micropile used in the present invention is not particularly limited and is preferably an X-ray photosensitive resin, specifically, an X-ray photosensitive resin containing PMMA (polymethyl methacrylate) is preferable, A material that can withstand physicochemical loads such as X-rays and heat in the production process is preferred. Furthermore, although it does not specifically limit as what supports the board | substrate of a functional micropile as a whole, Adhesive tape-like support materials, such as adhesive bandage and a medical tape, are preferable.
[0017]
With respect to the method for producing a functional micropile in the present invention, first, synchrotron radiation X-rays are irradiated on an X-ray photosensitive resin substrate containing PMMA through a mask having a specific pattern and then developed. Remove the part to make a master pattern. Next, a mold having an inverted pattern shape of the master pattern is manufactured by an electroforming process or the like. Thereafter, a product or a functional micropile having the same shape as the inverted pattern or master pattern of the mold is injection molded. The sugar content mixed with functional substances during injection molding is used as the molding material.
[0018]
That is, this manufacturing method
(A) an X-ray lithography process for forming a micropile pattern by irradiating an X-ray photosensitive resin with synchrotron radiation X-rays;
(B) A mold manufacturing process for producing a micropile mold by electroforming a reversed shape of a micropile pattern;
(C) an injection molding process for forming a functional micropile by injection molding a functional material-containing material based on a micropile mold;
(D) Exterior assembly process for commercialization of functional micropile,
It is a manufacturing method of the functional micropile characterized by comprising each manufacturing process.
[0019]
【Example】
The present invention will be specifically described below with reference to examples. However, the present invention is not limited to the following examples.
[0020]
Example 1
The multi-functional micropile of the present invention is used to cover the altered portion or discolored portion generated on a part of the face. The purpose can be achieved by producing a functional micropile mixed with functional powder of the same color as the skin of the subject by the production method of the present invention. If the area to be covered is large, the object can be easily achieved by using a plurality of areas. As for the size, the thickness of the stratum corneum is 100 μm or more and 300 μm or less as a standard, so that the height of the functional micropile is appropriate from 50 μm to 70 μm, and the tip of the functional micropile is sufficiently painless when used at 5 μm or less. be able to.
Therefore, a square substrate with a side of 1 cm square is made of PMMA material, and a cylindrical maltose pile having a diameter of 10 μm and a length of 60 μm is mixed on the substrate (mixed with 20% by weight of functional powder of the same color as the skin of the subject). ) Was produced by this manufacturing method. While this was lightly pressed against the subject's facial aza part, the substrate was removed from the facial aza part by gently tapping it with a pom-pom about 10 times. As a result, in the aza portion, the aza easily disappeared from the sight with respect to a 1 cm square part. In addition, according to the testimony of the test subject, it was “no pain during the above implementation”.
[0021]
Example 2
Recently, patient misunderstandings have become conspicuous in large hospitals. In particular, the misunderstanding of newborns is a tragedy. If there is any mark on the body surface, we think that such an accident can be easily prevented. Often, landmarks such as ribbons, pens, labels, etc. are used, but are often lost due to the patient's own behavior. If the mark can be embedded in the stratum corneum, the display can be retained stably in any behavior of the patient. As described above, a multi-function micropile having a symbol display function is extremely effective for preventing accidents involving patient misunderstandings.
Therefore, a square substrate with a side of 0.5 cm square is made of PMMA material, and a cylindrical maltose pile (mixed with 15% by weight of red food) having a diameter of 20 μm and a length of 70 μm is formed on the substrate. 2500 pieces were made. While this was lightly pressed against the arch of the foot of the newborn baby, it was lightly struck by a hand with the pompom about 10 times to remove the substrate from the arch. As a result, a red portion having a side of 0.5 cm square was easily colored on the arch. The test subject, the newborn, was in a sleep state during the implementation. The colored red part disappeared completely after about 2 months.
[0022]
Example 3
In the entertainment industry, the improvement of the make-up for theatrical works is a field where the improvement and improvement are intense, but the demand for reproducibility is very high even in the makeup technology. The method according to the present invention provides a simple, reproducible, and quick makeup method. If used in combination with the conventional method of application to the surface, it is possible to provide a new expression method and support the creation of a new performing arts culture.
Therefore, a circular substrate having a diameter of 0.3 cm is made of PMMA material, and a cylindrical maltose pile (mixed with 10% by weight of ink) on the substrate is 15 μm in diameter and 60 μm in length. 3000 pieces were made. With this pressed lightly against the back of the subject's hand, the substrate was removed from the back of the hand by lightly hitting it with the pompom about 10 times. As a result, a circular mole with a diameter of 0.3 cm was easily created on the back of the hand. According to the testimony of the test subject, “I did not feel any pain during the above implementation”. The mole disappeared completely after about 3 months.
[0023]
Example 4
In general, a cosmetic powder applied to the face for sunscreen is used, but it is easily removed by sweating, contact with foreign matter, etc. and often loses its effectiveness. If the sunscreen can be embedded in the face or body even if it is shallow in the face or body by the multi-functional micropile of the present invention, the effect can be surely sustained for several days, so it is far more effective than conventional application type functional products. can do.
Therefore, a circular substrate having a diameter of 1 cm is made of PMMA material, and a cylindrical maltose pile having a diameter of 10 μm and a length of 70 μm is mixed with 1% by weight of Pulsol MCX which is an organic ultraviolet shielding agent. ) Was produced by this production method. With this pressed lightly against the back of the subject's hand, the substrate was removed from the back of the hand by lightly hitting it with the pompom about 10 times. Thereafter, for one month, the subjects were exposed to direct sunlight on the back of the hand outdoors to examine the degree of sunburn on the back of the hand. As a result, it was found that the circular part having a diameter of 1 cm was not tanned on the back of the hand compared to the surrounding part. According to the testimony of the test subject, "During the above implementation, no pain was felt, and the implementation section did not feel any pain due to sunburn." The sunscreen effect disappeared after about 2.5 months.
[0024]
【The invention's effect】
According to the present invention, when a fine functional micropile mixed with a functional substance such as a functional powder such as a coloring material or a functional liquid such as an ultraviolet absorber is used, the tip or part of the micropile is applied to the skin. The functional substance can be inserted into the skin stratum corneum by remaining in the skin. The remaining material of the micropile is harmless to the living body because it is a carbohydrate. Moreover, the function in the skin stratum corneum can be maintained for several days to several months. Furthermore, it is possible to insert a functional substance into the skin stratum corneum painlessly, safely, efficiently and simply.
[Brief description of the drawings]
FIG. 1 is a schematic view showing an example of a functional micropile of a single pile according to claim 1 of the present invention.
FIG. 2 is a schematic view showing an example of a functional micropile having a constricted portion according to claim 6 of the present invention.
FIG. 3 is a schematic view showing an example of a functional micropile having a step according to claim 7 of the present invention.
FIG. 4 is a schematic view showing an example of an asymmetric cross-sectional functional micropile according to claim 2 of the present invention;
FIG. 5 is a schematic view showing an example of a functional micropile having a micro container according to claim 9 of the present invention.
FIG. 6 is a schematic view showing an example of a micropile having a capillary cavity according to an eleventh aspect of the present invention.
FIG. 7 is a schematic view showing an example of a functional multi-micropile according to claim 12 of the present invention.
FIG. 8 is a schematic view showing an example of a micropile having an antireflection platform according to claim 13 of the present invention.
[Explanation of symbols]
DESCRIPTION OF SYMBOLS 1 Single-functional micro pile 2 Substrate 3 Step part 4 Constriction part 5 Micro container part 6 Capillary part 7 X-ray reflection prevention stand

Claims (8)

(A) an X-ray lithography process for forming a micropile pattern by irradiating an X-ray photosensitive resin with synchrotron radiation X-rays;
(B) A mold manufacturing process for producing a micropile mold by electroforming the inversion shape of the micropile pattern , and (c) a function by injection-molding a functional substance-containing material based on the micropile mold. Injection molding process to form a micropile,
including,
A method for producing a functional micropile having a structure in which one or a plurality of piles each having a length of 0.5 to 500 μm are provided on a substrate . The method for producing a functional micropile according to claim 1, wherein the pile has a square or circular cross-sectional shape with a side or diameter of 0.1 to 100 μm . After the injection molding process,
(D) including an exterior assembly process for commercialization of the functional micropile,
The manufacturing method of the functional micropile of Claim 1 or 2 . The method for producing a functional micropile according to any one of claims 1 to 3, wherein the X-ray photosensitive resin is a resin containing polymethyl methacrylate (PMMA).   The method for producing a functional micropile according to any one of claims 1 to 4, wherein the functional substance is water-soluble powder cake, a coloring material, or an ultraviolet absorber.   The functional micropile is provided with a path that reaches the skin stratum corneum by contacting with the skin, and releases the functional substance to the stratum corneum. Of manufacturing functional micropile.   A substrate,
  A functional micropile having one or more piles provided on the substrate,
    The piles are respectively
      The length is 50 μm or more and 70 μm or less,
      Functional substances are mixed,
By providing a path to reach the skin stratum corneum by bringing the pile into contact with the skin, the functional substance mixed in each pile is released to the stratum corneum by dissolving the pile in the stratum corneum. in order to,
  Functional micropile.   The functional micropile according to claim 7, wherein the functional substance is a water-soluble powder cake, a coloring material, or an ultraviolet absorber.

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