JP3385645B2 - Drug-filled syringe - Google Patents

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a drug solution filling syringe. More specifically, the present invention relates to a syringe that is pre-filled with a drug solution and is capable of aseptically injecting the drug solution for business.

[0002]

2. Description of the Related Art There is a so-called prefilled syringe as an injector for aseptically injecting a drug solution, which is a cylindrical container whose both ends are open, filled with the drug solution, and both open ends of which are rubber stoppers. It is constituted by a combination of a so-called syringe outer cylinder closed by the above, a plunger for pushing out a drug solution from this syringe outer cylinder, and a means for communicating the inside of the syringe outer cylinder with the injection needle. The liquid medicine filling type injector of the present invention is a modified example of the prefilled syringe, and is composed of a barrel (syringe outer cylinder) prefilled with liquid medicine, a plunger inserted into the barrel, and a communication means. Many proposals have already been made for the above drug solution filling syringe, for example, those described in JP-A-49-68586, JP-B-51-22560, and JP-B-52-19435. is there.

The drug solution-filled syringe described in JP-A-49-68586 is provided with a diaphragm for closing the syringe outer cylinder at the tip opening thereof, and a diaphragm with a needle attached to the tip opening of the diaphragm. The needle is pierced to communicate the inside of the syringe outer cylinder with the outside.
The drug solution-filled syringe disclosed in Japanese Utility Model Publication No. 51-22560 is a pressing member (cap) in which the tip opening of the syringe outer cylinder has a small-diameter beak tube.
It is closed with a sealing packing that is crimped with, and this sealing packing is pierced with an injection needle attached to a case equipped with a fitting cylinder fitted so that it can move forward and backward, and tries to communicate the inside of the syringe outer cylinder with the outside. It is a thing. Further, in the drug solution-filled syringe described in Japanese Utility Model Publication No. 52-194358, the tip opening of the syringe outer cylinder is sealed with a rubber septum, and this rubber septum is moved relatively to the tip of the syringe outer cylinder. The syringe needle is pierced with the holder held by the holder that is pierced as much as possible to communicate the inside of the syringe outer cylinder with the outside.

[0004]

However, each of the above-mentioned drug solution-filled type injectors has a drawback that the size of the injection needle is limited because the injection needle having a specific shape is incorporated in advance. Further, in the drug solution-filled syringe disclosed in JP-A-49-68586, if the center of the diaphragm is made thick, it becomes difficult to pierce it with a needle, and if the center of the diaphragm is made thin, airtightness is impaired. It has drawbacks such as the possibility that the chemical solution is vigorously poured out at the time of communication. In addition, the drug solution-filled syringe disclosed in Japanese Utility Model Publication No. 51-22560 has a large number of parts, which is troublesome to assemble, and the case with the injection needle fitted at the time of assembly is fitted to an appropriate position of the mounting cylinder. It has the drawback of being difficult to handle. Generally speaking, when using a syringe, it is preferable that the shoulder of the syringe is not bulky and compact, because it is easy to operate. Further, in recent years, a large-capacity syringe capable of not only injecting a small amount of drug solution but also injecting a large dose (for example, 20 to 50 cc) has been strongly desired.

In view of the above circumstances, the present invention makes it possible to use injection needles of any size, facilitate the piercing operation, securely fix the communication needle after piercing, have high operability during injection, and have a large capacity. An object of the present invention is to provide a drug solution-filled syringe that can use a barrel of the above.

[0006]

According to a first aspect of the present invention, there is provided a liquid medicine filling type syringe in which a body having a flange at an open rear end, a neck having a diameter smaller than that of the body, and a neck connected to the body . The mouth is closed with a rubber stopper, the barrel is filled with pre-prepared liquid medicine, and the rear end of the barrel is closed and liquid is pushed out from the rear end of the barrel. A plunger inserted tightly and slidably, a communication needle for puncturing a rubber stopper of the mouth, a guide for a piercing operation that detachably accommodates the communication needle from below and pushes down the communication needle. Insert it into the barrel body so that
A stationary and consists of a removal freely cap, the mouth
The outer diameter of the part is larger than that of the neck part so that the claw part described later can be engaged with the part.
The communication needle is large in size and has a substantially cylindrical shape in which an injection needle mounting portion is formed at an upper end and a puncture portion is formed at a lower end, and a lower surface fixed to the needle body is open. The engaging member is formed with a claw portion at a lower end thereof which allows the barrel to be inserted into the mouth portion from above and restrains the upward pulling out. According to a second aspect of the present invention, there is provided the drug solution-filled syringe according to the first aspect of the present invention, wherein the rib that bites into the upper surface and the outer peripheral surface of the mouth is substantially cylindrical when the communicating needle is punctured in the mouth of the barrel. The engaging member is formed on the lower surface of the top plate and the inner peripheral surface of the side wall. According to a third aspect of the present invention, in the liquid medicine filling type syringe of the first aspect, the inner peripheral surface of the claw portion of the substantially cylindrical engagement member abuts in a state in which the communication needle is punctured in the mouth portion of the barrel. The protrusion is formed on the outer periphery of the neck portion of the barrel. According to a fourth aspect of the present invention, in the medical solution filling syringe according to the first aspect, the cap includes a cap body that accommodates the communication needle, and a cylindrical skirt portion that is formed at the lower end of the cap body. Inside the body,
A female luer-shaped accommodating portion for accommodating the injection needle mounting portion of the communication needle and a holding portion that abuts on an upper surface of the substantially cylindrical engagement member are formed, and an inner wall of the skirt portion has a barrel body. It is characterized in that a rib is formed in sliding contact with the outer peripheral surface of the portion. According to a fifth aspect of the present invention, in the medical solution filling type injector according to the first aspect of the present invention, a fitting protrusion is formed on the outer periphery of the rear end of the barrel, and a fitting recess is formed on the inner periphery of a flange separate from the barrel. The flange is detachably attached to the barrel.

[0007]

According to the invention of claim 1 , when the communicating needle is accommodated in the cap and pushed in the axial direction of the barrel, the puncture portion of the communicating needle is pierced through the rubber plug and is inserted into the mouth portion. While piercing, the engaging member of the communicating needle is WAM flexures outward piercing
When the above is completed, the claw portion of the engaging member fits into the lower end of the mouth portion, and the communicating needle is fixed to the mouth portion of the barrel. Then, when the cap is pulled out, the injection needle mounting portion of the communication needle is exposed, so a desired injection needle may be attached to the injection needle mounting portion. After that, if the plunger is pushed in, the drug solution in the barrel can be injected. Further, in the present invention, since the injection needle mounting portion is formed on the communication needle, injection needles of various sizes can be attached. Also, the communication needle need only be large enough to fit in the mouth of the barrel, so it can be made smaller and the cap can be removed easily.
Therefore, after removing it, it is slim and not bulky in dimensions, which makes the injection operation easier. Moreover, since the diameter of the barrel can be increased regardless of the size of the communicating needle, a large-capacity syringe can be obtained. According to the invention of claim 2, the rib has a mouth.
As it bites into the outer peripheral cover, the communication needle is firmly fixed
When attaching a lure type syringe to the communication needle,
Even if you push it in while turning it, the communication needle does not idle, so
It can be installed easily and securely. Claim
According to the invention of Item 3, the communicating needle is punctured in the mouth portion of the barrel.
And the inner peripheral surface of the claw comes into contact with the protrusion on the outer periphery of the barrel neck.
Since there is no backlash in the radial direction, the communication needle is firmly
It is fixed to the mouth of the barrel and the needle can be easily attached.
Become. According to the invention of claim 4, the lure tip of the communication needle
Since it is closed with the female of the cap, communication operation is
No liquid leakage will occur until the end. According to the invention of claim 5,
The flange can be removed when not in use.
Make the outer diameter of the container thicker and bulky even as a large-capacity syringe
There is no.

[0008]

Embodiments of the present invention will now be described with reference to the drawings. (First Embodiment) FIG. 1 is a longitudinal sectional view of a drug solution filling type injector according to a first embodiment of the present invention, FIG. 2 is an enlarged sectional view of a cap 4, a communicating needle 3 and a mouth portion 13, and FIG. 3 is a sectional view taken along line III-III, FIG. 4 is a sectional view taken along line IV-IV in FIG. 2, FIG. 5 is an explanatory view of a piercing operation, and FIG. 6 is a state diagram after completion of piercing.

As shown in FIG. 1, the liquid medicine injector A of this embodiment comprises a barrel 1, a plunger 2, a communicating needle 3, a cap 4 and a flange 5. The barrel 1 is a so-called syringe outer cylinder, which is usually made of glass, and has a body portion 11 provided with a flange integrally or separately at the open rear end, and a neck portion 12 having a small diameter connected to it.
The mouth portion 13 is connected to the mouth portion 13, and the drug solution D is filled inside. Further, when a separate type flange 5 is attached, a fitting protrusion 14 for detachably attaching the flange 5 is formed on the outer periphery of the rear end of the barrel 1.

The plunger 2 is composed of a gasket 21 inserted into the rear end of the barrel 1 in a liquid-tight manner and slidably, and a rod 22 connected thereto. The shape of the gasket 21 may be similar to that of a normal syringe, and rubber-like elastic bodies such as butyl rubber, isoprene rubber, styrene-butadiene rubber, and olefin elastomer are preferably used as the material. This plunger 2 is a barrel when not in use
No. 1 is closed, and this is pushed in for the purpose of discharging the liquid medicine.

The flange 5 may be integral with the barrel 1 as described above or may be a separate body. However, in the case of a separate body, a hole 51 that is closely fitted to the outer periphery of the barrel 1 is formed. A fitting recess 52 is formed on the inner circumference. The flange 5 is fitted into the barrel 1 by fitting the fitting recess 52 into the fitting protrusion 14.
It is attached to and serves as a clue to push the plunger 2 in use. Of course it can be removed when not in use,
There is an advantage that it is not bulky even if it is a large-capacity barrel with a large diameter.

The details of the mouth portion 13, the communicating needle 3 and the cap 4 of the barrel 1 will be described with reference to FIGS. As shown in FIG. 2, the mouth portion 13 of the barrel 1 is formed to have an outer diameter slightly larger than that of the neck portion 12, and a rubber plug 15 is fitted in the inner cavity thereof. The rubber plug 15 has a thin central portion 16 and is fixed by an aluminum cover 17 so as not to come off from the mouth portion 13 of the barrel 1. Although this mouth portion 13 is a drug solution pouring port, it is different from the tip of a normal syringe outer cylinder which is a drug solution pouring port and an injection needle mounting part in that it is closed by the rubber stopper 15 as described above.

The communicating needle 3 is a hollow member for piercing the rubber plug 15 to open the inner cavity of the barrel 1 to the outside, and has a needle body 30 and a substantially cylindrical shape integrally formed with the needle body 30. Of the engaging member 35. The needle body 30 includes a luer tip 31 which is an injection needle mounting portion, and a puncture portion 33 having a cutting edge 32 formed at the tip thereof, and a drug solution passage 34 extends axially through the central portion. The engaging member 35 has a top plate 36 and a cylindrical side wall 37. As shown in FIGS. 2 and 4, the side wall 37 of the engaging member 35 has several slits 38 at equal intervals in the circumferential direction. And a claw portion 39 is formed at the lower end of each piece of the side wall 37 separated by each slit 38. As shown in FIGS. 2 and 3, ribs 51 having a cross shape are formed on the lower surface of the top plate 36 of the engaging member 35, and ribs 52 are also formed on the inner periphery of the side wall 37. It is preferable that these ribs 51 and 52 have, for example, a triangular cross-section and that they bite into the aluminum cover 17 covering the mouth portion 13.

The cap 4 is a cylindrical accommodating needle accommodating portion.
41 and a cylindrical skirt portion 42 extending from the lower end thereof. A female luer 43, which is a housing portion for housing the luer tip 31 of the communication needle 3, is formed in the center of the housing portion 41.
As shown in FIGS. 3 and 4, several ribs 44 are formed on the inner wall of the housing portion 41. The rib 44 is cut in the middle to form a pressing portion 45, which abuts on the upper surface of the top plate 36 of the communication needle 3. The lower end of the rib 44 is tapered so that the claw portion 39 of the communication needle 3 opens outward in the radial direction.
Is formed into 46. The skirt portion 42 is a portion fitted into the body portion 11 of the barrel 1, and four ribs 47 are formed on the inner peripheral surface thereof. Distance between two facing ribs 47 (inner diameter)
Is slightly smaller than the outer diameter of the barrel 11 of the barrel 1, and the cap 4
When is pushed into the outer periphery of the barrel 1, the rib 47 is pushed in while being crushed a little, and the cap 4 can be pushed in without rattling. However, since this cap 4 is to be removed at the time of injection, it must not generate a strong fitting force that makes removal difficult.

As a material for forming the barrel 1, the rod 22 of the plunger 2 and the cap 4, a transparent synthetic resin such as polypropylene, polyethylene or polyester is preferably used (glass is also preferably used for the barrel 1). Be done). Moreover, as a material for forming the communication needle 3, a synthetic resin such as polycarbonate, ABS resin, or polypropylene is suitable.

Next, the piercing operation of this embodiment will be described.
As shown in FIG. 1, the communication needle 3 is accommodated in the cap 4, and the skirt portion 42 of the cap 4 is fitted to the shoulder portion of the barrel 1, and then the cap 4 is pushed down as shown in FIG. direction). The communication needle 3 pushed downward by the cap 4 starts to pierce the rubber plug 15 fitted in the mouth portion 13 at the puncture portion 33 having the blade tip 32, and at this time, the claw portion 39 covers the mouth portion 17.
It is bent radially outward while descending along. This bending is reasonably allowed by the slit 38 and the taper 46. Further, the rib 47 of the skirt portion 42 fits on the outer periphery of the barrel 1 and guides the axial insertion of the cap 4. When the above piercing operation is completed, the puncture portion 33 of the communicating needle 3 completely enters the barrel 1, and the claw portion 39 fits into the lower end of the mouth portion 13 and thereby compresses tightly in the vertical direction. 51 digs into the top of cover 17, and rib 52 covers
It bites into the side surface of 17 to firmly fix the communicating needle 3 to the mouth portion 13. After that, when the cap 4 is pulled out, the luer tip 31 of the communication needle 3 is exposed, and a desired injection needle may be fitted and attached thereto. Then, by pushing the plunger 2 shown in FIG. 1 in the same manner as a normal syringe, the drug solution in the barrel 1 can be injected.

The present embodiment has the following advantages.
The communication needle 3 is composed of a needle body 30 and an engagement member 35.
Since the outer diameter of 35 is slightly larger than that of the mouth portion 13, 35 is very small. Further, since the cap 4 is designed to be removed at the time of use, the shoulder portion of the barrel 1 is not bulky at the time of use. Therefore, it is convenient and highly convenient. Since one end of the communication needle 3 is configured as the luer tip 31, an injection needle of any size can be used.
Since the communication needle 3 is only inserted into the mouth portion 13 and is not externally attached to the shoulder portion of the barrel 1 and the flange 5 is detachable, the bulkiness of the flange 5 need not be taken into consideration. The diameter can be made large and a large-capacity syringe can be made. Since the communication needle 3 can be pierced by simply pushing in the cap 4, the operation is easy. Since the luer tip of the communication needle 3 is closed by the female luer 43 of the cap 4 until the communication operation is completed, liquid leakage does not occur. Does not happen.
At the same time when the piercing operation is completed, the engagement member 35 grasps the mouth portion 13,
Since the ribs 51 and 52 bite into the outer peripheral cover 17 of the mouth portion 13 while holding the mouth portion 13 in the vertical direction by the top plate 36 and the claw portion 39, the communication needle 3 is firmly fixed and rattles. To be prevented. Therefore, when attaching a threaded or lure coupling type injection needle to the communication needle 3, even if the injection needle is rotated, the communication needle 3 does not idle, so that the attachment is easy.

(Second Embodiment) FIG. 7 is a sectional view of a main part of a drug solution filling type injector according to a second embodiment of the present invention, FIG. 8 is a sectional view taken along line VIII of FIG. 7, and FIG. 9 is IX of FIG.
It is a line sectional view. In this embodiment, as shown in FIGS. 7 and 8, ribs are provided on the lower surface of the top plate 36 of the engaging member 35 of the communication needle 3.
51 are formed, and ribs 52 are formed on the inner periphery of the side wall 37. The rib 52 is formed at a position displaced in the circumferential direction from a cantilever claw 55 described later. Further, as shown in FIGS. 7 and 9, a cantilever type claw 55 is formed at the lower end of the side wall 37 of the engaging member 35 so as to extend obliquely upward from the lower end. Since the cantilevered claw 55 is bent outward in the radial direction, the side wall 37 of the engaging member 35 is not provided with the slit 38 as in the first embodiment. Then, as shown in FIG.
A protrusion 18 is formed on the lower portion of the neck 12 of the barrel 1.
The outer diameter of the protrusion 18 is substantially equal to the inner diameter of the lower end portion 55a of the claw portion 55.

In this embodiment as well, the piercing operation of the communicating needle 3 can be performed by pushing in the cap 4 as in the first embodiment. Then, in the state where the piercing is completed, as shown in FIG. 10, the cantilever claw 55 fits into the lower end surface of the mouth portion 13,
Hold it up and down to let the rib 51 bite into the cover 17.
Further, the lower end portion of the cantilever claw 55 contacts the protrusion 18 to eliminate radial play. Therefore, the communication needle 3 is firmly fixed to the mouth portion 13 of the barrel 1. Therefore, the injection needle can be easily attached.

[0020]

According to the first aspect of the present invention, since the injection needle mounting portion is attached to the communication needle, injection needles of various sizes can be attached. Also, the communication needle is sufficient if it fits in the mouth of the barrel, so after removing the cap, there is no bulky dimension and it is slim.
The injection operation becomes easier. Moreover, since the diameter of the barrel can be increased regardless of the size of the communicating needle, a large-capacity syringe can be obtained. From claim 2
According to Ming, the rib bites into the outer peripheral cover of the mouth, so
The needle is firmly fixed and the lure type syringe is connected.
When installing on the needle thread, even if you push it in while rotating it
Since it does not run idle, it can be installed easily and securely.
You can According to the invention of claim 3, the communication needle is
When you puncture the mouth of the rel, the inner surface of the claw will
Since it contacts the protrusion on the outer circumference of the part, there is no play in the radial direction.
, The communication needle is firmly fixed to the mouth of the barrel,
The needle can be attached easily. According to the invention of claim 4,
The connecting needle's lure tip is closed with the cap's female luer.
Liquid leakage does not occur until the communication operation is completed. Contract
According to the invention of claim 5, the flange is removed when not in use.
Since it can be stored, the outer diameter of the barrel is made thicker and a large capacity syringe
But it doesn't get bulky.

[Brief description of drawings]

FIG. 1 is a longitudinal sectional view of a drug solution filling syringe according to a first embodiment of the present invention.

FIG. 2 is an enlarged cross-sectional view of the cap 4, the communicating needle 3 and the mouth portion 13 shown in FIG.

FIG. 3 is a sectional view taken along line III of FIG.

FIG. 4 is a sectional view taken along line IV of FIG.

FIG. 5 is an explanatory diagram of a piercing operation according to the first embodiment.

FIG. 6 is a state diagram after completion of piercing in the first embodiment.

FIG. 7 is a vertical cross-sectional view of a drug solution filling syringe according to a second embodiment of the present invention.

8 is a sectional view taken along line VIII of FIG.

9 is a sectional view taken along line IX of FIG.

FIG. 10 is a state diagram after completion of piercing in the second embodiment.

[Explanation of symbols]

1 Barrel 2 Plunger 3 Communication needle 4 Cap 13 Mouth 15 Rubber stopper 18 Protrusion 30 Needle 31 Luer tip 33 Puncture 35 Engagement member 39 Claw 51 Rib 52 Rib 55 Cantilever claw

─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Akifumi Aramata 3-9-3 Honjo Nishi, Kita-ku, Osaka City, Osaka Prefecture Nissho Co., Ltd. (72) Inventor Kenji Himejima 3-chome, Honjo Nishi, Kita-ku, Osaka City, Osaka Prefecture No. 9 No. 3 in Nissho Co., Ltd. (56) Reference Japanese Unexamined Patent Publication No. 52-113593 (JP, A) Actual exploitation Sho 59-100433 (JP, U) Actual exploitation Sho 48-20290 (JP, U) Actual exploitation Sho 48 −8990 (JP, U) (58) Fields investigated (Int.Cl. ⁷ , DB name) A61M 5/24

Claims (5)

(57) [Claims] 1. A body having a flange at an open rear end.
And it is connected to itFrom the bodySmall diameterofNeck and it
In a rowRuConsisting of a mouth and the mouth is closed with a rubber stopper
And a barrel filled with pre-prepared liquid medicine, In order to close the rear end of the barrel and push out the liquid medicine,
A plan inserted in a liquid-tight and slidable manner from the rear end of the barrel
Ja, A communication needle for puncturing the rubber stopper of the mouth, The communication needle is detachably accommodated from below, and the communication needle is
It serves as a guide for pushing downAs said barrel barrel
Can be inserted into and removed from the unitLike a cap
It consists ofThe mouth part has a neck so that the outer diameter of the mouth part is engaged with the claw part described later.
It is larger than the section, The communication needle has an injection needle mounting portion formed at the upper end and a lower end at the lower end.
The needle body on which the puncture portion is formed and the lower surface fixed to the needle body are
And a substantially cylindrical engagement member that is open,
The lower end of the material is allowed to be inserted into the mouth of the barrel from above.
A claw part is formed to hold it and hold it upwards.
A syringe filled with a drug solution characterized in that 2. A rib that bites into an upper surface and an outer peripheral surface of the mouth portion of the barrel when the communicating needle is pierced into the mouth portion of the barrel is provided on the lower surface of the top plate and the inner peripheral surface of the side wall of the substantially cylindrical engaging member. The drug solution filling syringe according to claim 1, which is formed. 3. A protrusion on the outer periphery of the neck of the barrel, with which the inner peripheral surface of the claw portion of the substantially cylindrical engaging member abuts is formed in a state in which the communicating needle is pierced into the mouth of the barrel. The drug solution filling syringe according to claim 1. 4. The cap comprises a cap main body for accommodating the communication needle and a cylindrical skirt portion formed continuously from the lower end of the cap main body. a female luer-shaped housing part for accommodating the parts, the generally are pressing portion abutting against the formation on the upper surface of the cylindrical engagement member, the inner wall of the skirt, sliding contact rib on the body portion outer peripheral surface of the barrel The drug solution filling syringe according to claim 3, wherein the syringe is formed. 5. A fitting protrusion is formed on the outer circumference of the rear end of the barrel, and a fitting recess is formed on the inner circumference of a flange separate from the barrel, so that the flange can be detachably attached to the barrel. The drug solution filling syringe according to claim 1, wherein