JP3241922B2 - Oral composition - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an oral composition containing sodium chloride, sodium bicarbonate and a bactericide, and more particularly, to an excellent treatment and prevention effect for periodontal disease and to eliminate the unpleasant saltiness of salt. In addition, the present invention relates to an oral composition that can maintain a high effective concentration of a fungicide in the oral cavity without blending a high concentration of the fungicide, and has good taste and feel.

[0002]

BACKGROUND OF THE INVENTION Periodontal diseases are two major diseases in the oral cavity region along with caries. In particular, alveolar pyorrhea, in today's aging society,
It is a serious problem. Therefore, the prevention and treatment thereof are very important for oral hygiene, and toothpastes containing salt as a medicinal agent are commercially available as dentifrices for such purposes. Salt is thought to have an effect of improving local gingival circulation by absorbing tissue fluid in inflamed gingiva.

On the other hand, bactericides such as chlorhexidine hydrochloride, quaternary ammonium salts, triclosan, hinokitiol, isopropylmethylphenol, and alkyldiaminoethylglycine hydrochloride are widely used for the prevention and treatment of gingivitis, like salt. The disinfectant is completely different from the action of the above-mentioned salt, and exerts its effect by acting on periodontal disease-causing bacteria which is a direct cause of periodontal disease. Since a synergistic effect can be expected for the prevention and treatment of gingivitis, many toothpastes containing both are commercially available.

However, when a high concentration of sodium chloride is added to a toothpaste containing salt and a bactericide for the purpose of improving the gingivitis, saltiness is increased and discomfort is caused, and at the same time, salivary glands are added. Stimulates the salivary secretion, resulting in a problem that the salt is diluted and the effective concentration of the salt in the oral cavity is reduced. Further, the bactericide contained in the toothpaste is also diluted with saliva like salt, and there is a problem that the effectiveness is lower than when the bactericide is used alone. To solve the problem of the decrease in the effective concentration of the fungicide, it is possible to prevent the decrease in the effective concentration of the fungicide by blending a high concentration of the fungicide in advance. Is limited in color, taste, safety, etc.
Some measures are required.

Accordingly, an object of the present invention is to provide a fungicide in the oral cavity which is excellent in the treatment and prevention of periodontal disease, has no unpleasant saltiness of salt, and does not contain a high concentration of a fungicide. An object of the present invention is to provide an oral composition which can maintain an effective concentration at a high level and has good taste and feel.

[0006]

Means for Solving the Problems The inventors of the present invention have conducted intensive studies to achieve the above object, and as a result, the following (1) to (1) to
It has been found that the effect of (3) is achieved. (1) For example, a dentifrice containing 15% by weight of sodium chloride, 15% by weight of sodium bicarbonate, and 100 ppm of benzethonium chloride (bactericide) is 100% by weight of salt and 15% by weight of benzethonium chloride.
Compared with the dentifrice containing 15 ppm by weight of sodium bicarbonate and 100 ppm of benzethonium chloride, an extremely excellent gingivitis improving effect can be obtained. A dentifrice containing 15% by weight of sodium chloride, 15% by weight of sodium bicarbonate, and 100 ppm of benzethonium chloride is made of salt 3
Compared to a dentifrice containing 0% by weight and 100 ppm of benzethonium chloride, almost the same dehydration effect (tightening effect) can be obtained, and the former is much less salty than the latter, so There is little promotion of saliva secretion, and as a result, the effective concentration of benzethonium chloride in the oral cavity can be kept high. (2) By using salt having a specific average particle size, the dissolution rate of salt in saliva can be adjusted, and as a result,
The saltiness during dentifrice can be moderately adjusted, and not only can the palatability be significantly increased, but also the effective oral concentration of benzethonium chloride incorporated can be kept high. (3) By using baking soda having a specific average particle size, the time during which the granular salt can be palpated in the oral cavity can be freely adjusted, and as a result, an excellent taste and feel can be imparted to the dentifrice. In addition, the saltiness can be adjusted appropriately, so that the effective concentration of benzethonium chloride in the oral cavity can be kept high. .

The present invention has been made on the basis of the above-mentioned findings, and comprises the following components (a), (b) and (c), wherein the content of the component (a) is 10 to 30% by weight. ,
Weight ratio of component (a) to component (b) (salt / baking soda)
Is in the range of 1 / 0.5 to 1/3 . (A) Salt (b) Baking soda (c) Chlorhexidine salts and quaternary ammonium salts
One or more fungicides selected from the group consisting of

Hereinafter, the oral composition of the present invention will be described in detail. The salt which is the component (a) of the oral composition of the present invention has an average particle diameter of 150 to 450 μm, preferably 1 to 450 μm.
50 to 350 μm, particularly preferably 150 to 300 μm
m, most preferably from 200 to 300 μm granular salt, and by using such granular salt,
The effective concentration in the oral cavity of the fungicide (c) can be kept high. The average particle size of the granular salt is 15
When the thickness is less than 0 μm, salt is rapidly dissolved in saliva in the oral cavity, and saltiness may be rapidly developed.
If the average particle size of the granular salt is more than 450 μm, the feeling in the oral cavity becomes worse, and in extreme cases, the soft tissue in the oral cavity such as the gums may be damaged.

The baking soda as the component (b) of the oral composition of the present invention has an average particle size of 45 to 450 μm, preferably 100 to 300 μm, and particularly preferably 200 to 300 μm.
It is preferable to use 300 μm granular baking soda. By using such granular baking soda, the effective concentration of the fungicide (c) in the oral cavity can be kept high. Also,
If the average particle size of the particulate baking soda is less than 45 μm, baking soda is rapidly dissolved in saliva in the oral cavity, so that the time for palpating the granular salt is reduced. The average particle size of the granular sodium bicarbonate is 450 μm.
If it is more than m, the feeling may be worsened, and within the average toothbrushing time of 2 minutes, baking soda cannot be completely dissolved in saliva in the oral cavity, and it will be spit out without effect. Sometimes.

The method for producing the above-mentioned granular sodium bicarbonate is not particularly limited, but crystals precipitated from pure sodium carbonate solution through carbon dioxide at 50 ° C. or less are filtered off, dried in a stream of carbon dioxide and pulverized. The one obtained by the following production method is preferable.

[0011] Salts of chlorhexidine disinfectants as component (c) of the oral composition of the present invention, chlorhexidine and the like chlorhexidine to gluconate chloro, as the quaternary ammonium salts, benzethonium chloride , Cetylpyridinium chloride, decalinium chloride,
And benzalkonium chloride .

In order for the oral composition of the present invention to exhibit an appropriate salt taste and to exhibit the maximum dehydration effect, the above-mentioned component (a) is added in an amount of 10% by weight or more, especially 10 to 3%.
It is preferably contained in an amount of 0% by weight, more preferably 15 to 20% by weight. In the composition for oral cavity of the present invention, the weight ratio (salt / baking soda) of the salt (a) and the sodium bicarbonate (b) is in the range of 1 / 0.5 to 1/3. Of which, especially 1
It is preferably within the range of /0.8 to 1/2, more preferably within the range of 1 / 1.1 to 1/2. Further, the oral composition of the present invention may contain the fungicide as the component (c) in an amount of 0.001 to 0.001.
The content is preferably 0.1% by weight, particularly preferably 0.005 to 0.02% by weight.

The oral composition of the present invention contains, as the salt (a) and the sodium bicarbonate (b), a granular salt having a particle size outside the range of 150 to 450 μm and a particle size of 4%.
Granular sodium bicarbonate outside the range of 5 to 450 μm may be contained, but the content of granular salt having a particle size of less than 150 μm and the content of granular salt having a particle size of more than 450 μm are all 10% by weight or less. Preferably, the content of particulate baking soda having a particle size of less than 45 μm is 50% by weight or less, particularly 20% by weight or less, and the content of particulate baking soda having a particle size of more than 450 μm is 3%.
It is preferably 0% by weight or less, particularly preferably 15% by weight or less.

The oral composition of the present invention comprises the above-mentioned (a) salt, (b) sodium bicarbonate and (c) a bactericide in an oral vehicle according to a conventional method, and a toothpaste, a liquid dentifrice, a powder dentifrice. And a gingival coating (oral pasta). When the oral composition of the present invention is used as a dentifrice, the oral vehicle may be a water-insoluble abrasive (component (d)), a binder, a humectant, a surfactant, a flavor, a sweetener. , Preservatives, dyes, water, water-soluble fluorides, silicones, and other active ingredients are appropriately used.

The water-insoluble abrasive [component (d)] includes calcium hydrogen phosphate for toothpaste, heavy calcium carbonate, light calcium carbonate, calcium pyrophosphate, insoluble sodium metaphosphate, potassium metaphosphate, silicic acid anhydride, and hydrated water. Examples include silicic acid, aluminum silicate, calcium silicate, zirconium silicate, bentonite, zeolite, aluminum oxide, aluminum hydroxide, alumina, resin, and mixtures thereof. Of these, silicic anhydride, hydrous silicic acid, calcium silicate,
Aluminum silicate, heavy calcium carbonate, light calcium carbonate, aluminum hydroxide, and alumina are particularly preferable for obtaining a dentifrice having good storage stability, and hydroxylation is preferable in that good flavor stability can be obtained. Aluminum is more preferred.

Examples of the binder include sodium carboxymethylcellulose, methylcellulose, hydroxyethylcellulose, alginate, carrageenan, gum arabic, polyvinyl alcohol, tragacanth gum,
Starch and sodium polyacrylate;
Further, as the wetting agent, polyethylene glycol,
Examples include propylene glycol, sorbitol, glycerin, maltitol, xylitol and the like. Of these, glycerin, sorbitol and the like are particularly preferred.

The surfactant is used as a foaming agent or a stabilizer for oily substances, and various surfactants are used. Examples of preferred surfactants include alkyl sulfates, alkyl benzene sulfonates,
Monoalkyl phosphate salts, N-acyl sarcosinates, N-acyl glutamates, polyoxyethylene hydrogenated castor oil, polyoxyethylene polyoxypropylene block copolymers (pluronic type), sucrose fatty acid esters, alkyl glycosides, Sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, alkyldimethylamine oxide, carbobetaine, hydroxycarbobetaine, phosphobetaine, hydroxyphosphobetaine, sulfobetaine, hydroxysulfobetaine and the like. Among these, water-soluble nonionic surfactants such as polyoxyethylene hydrogenated castor oil, polyoxyethylene polyoxypropylene block copolymer, sucrose fatty acid ester, alkyl glycosides, sorbitan fatty acid ester, and polyoxyethylene sorbitan fatty acid ester; Amphoteric surfactants are particularly preferred.

Further, as the above-mentioned fragrance, spearmint oil, peppermint oil, winder green oil, sassafras oil, clove oil, sage oil, eucalyptus oil, mayonnaise oil,
Natural flavors such as cinnamon oil, thyme oil, lemon oil and orange oil; and synthetic flavors such as 1-menthol, anethole, carvone, eugenol, thymol, methyl salicylate and the like. In addition, as the sweetener, saccharin,
Saccharin sodium, stevioside, neohesperidyl dihydrochalcone, berraltin, p-methoxycinnamic aldehyde, glycyrrhizinate, aspartame (aspartylphenylalanine methyl ester) and the like. Further, as the preservative, benzoic acid, sodium benzoate, parahydroxybenzoic acid,
And parahydroxybenzoic acid esters.

Examples of the water-soluble fluoride include sodium fluoride and sodium monofluorophosphate. Further, as the other active ingredients, chlorophyll compounds, ε-aminocaproic acid, tranexamic acid, vitamin C, vitamin E, nicotinic acid ester, allantoinchlorohydroxyaluminum, azulene,
Lysozyme chloride, β-glycyrrhetinic acid, dipotassium glycyrrhizinate, protease, crude drug extract and the like can be mentioned.

When the oral composition of the present invention is used as a paste-like dentifrice composition such as a toothpaste or a liquid dentifrice, all the components of the oral vehicle for a dentifrice may be blended. Basically, a water-insoluble abrasive (component (d)) is used in an oral vehicle in an amount of 10 to 75% by weight, a binder is used in an amount of 0.5 to 5% by weight, a wetting agent and water are used in an amount of 10 to 85%. It is preferable that the content is contained by weight. Here, the content of the water-insoluble abrasive [component (d)] is 20 to 20 in the case of toothpaste.
It is preferably 75% by weight, and in the case of a liquid dentifrice, 10 to 30% by weight. When a solid composition such as a powdered dentifrice is used, solid components can be blended among the components of the oral vehicle for the dentifrice, but basically, a water-insoluble abrasive [ (D) component] in an amount of 60 to 99% by weight. In addition, it is preferable that the flavor and sweetener are incorporated in the oral vehicle in a total amount of 0.01 to 5% by weight.

When the oral composition of the present invention is used as a gingival coating, the oral vehicle may be an oily component or a water-soluble polymer (component (e)), a wetting agent, a surfactant, and the like. , Fragrances, sweeteners, preservatives, pigments, water, water-soluble fluorides, silicones, and other active ingredients are appropriately used.

Examples of the oily component [component (e)] include higher fatty acid esters such as petrolatum, lanolin, liquid paraffin, natural fats and oils, isopropyl myristate, octyldodecyl myristate, and higher fatty acids such as palmitic acid and isostearic acid. , Higher alcohols such as myristyl alcohol and cetyl alcohol, squalane, silicone oil and the like. As the water-soluble polymer [component (e)], those exemplified above as the binder can be used, and among them, hydroxyethyl cellulose is particularly preferable. Further, water-soluble polymers such as polyethylene glycol and polyoxyethylene polyoxypropylene block copolymers can also be suitably used. The gingival coating composition contains the oily component or the water-soluble polymer (component (e)) in the coating composition in an amount of 10 to 50% by weight,
It is preferable to contain 20 to 70% by weight of a wetting agent and water.

The oral composition of the present invention has a pH
Is preferably in the range of 5 to 9.5, particularly 6 to 8.

[0024]

The oral composition of the present invention does not cause unpleasant saltiness of salt, and as a result, suppresses salivary secretion, thereby reducing the effective concentration of the fungicide in the oral cavity. It acts effectively without being treated, and the excellent dehydrating power, bactericidal power and the effect of the bactericide of salt and baking soda act synergistically to effectively prevent periodontal disease.

[0025]

EXAMPLES The present invention will be described below in more detail with reference to examples, but the present invention is not limited to these examples. still,
The average particle size of the granular salt and granular sodium bicarbonate used in the examples was determined by the following measurement method.

[Method of measuring average particle size of granular salt and granular sodium bicarbonate] 1) 50 g of oral composition is placed in a 300 ml beaker of granular salt, 5000 ml (100 times) of saturated saline is poured into the beaker, and the mixture is stirred with a homomixer. Completely suspend the oral composition. Baking soda is only about 1% soluble in saturated saline, but by dissolving it in a large excess of saturated saline, only sodium bicarbonate can be completely dissolved. The granular salt is recovered from the above suspension using a 200-mesh sieve (U.S.A. standard sieve LC584), and washed on the mesh with saturated saline and ethanol. After leaving in an electric dryer (100 ° C) for about 30 minutes,
After collecting the collected granular salt in a petri dish and measuring the weight, meshes of various sizes (35, 45, 60, 80, 120,
(170, 230, 325 mesh), and the weight of the granular salt remaining on each sieve is measured. From this weight distribution, a geometric mean diameter is determined and defined as the mean particle diameter. 2) Granular sodium bicarbonate The measurement is performed in the same manner as in 1) except that a saturated aqueous sodium bicarbonate solution is used in place of the saturated saline solution in the method of 1).

Example 1 and Comparative Examples 1 and 2 Toothpastes 1 to 3 having the following composition were prepared according to a conventional method. The resulting dentifrices 1 to 3 were evaluated for their gingivitis-improving effect by the following method. The results are shown in Table 1 below. [Evaluation method for improvement effect of gingivitis] Subjects: A total of 30 men and women with mild gingivitis were divided into three groups. 2. How to use toothpaste; 2 days after breakfast and before going to bed
Each time, 1 g of the test toothpaste is placed on a toothbrush [having a “ball tip” made by Kao Corporation; hardness is normal] and brushed for 3 minutes. 3. The test sites were the upper and lower anterior teeth, and PMAindex, an index of gingivitis, was measured at the first medical examination and 4 weeks later, and the average value of each was calculated. And the improvement degree of gingivitis was calculated by the formula shown in the following [Equation 1].

[0028]

(Equation 1)

Toothpaste 1 (Comparative Example 1) (% by weight) ・ Purified grade purified salt (average particle size 250 μm) 15.0 ・ Sorbitol 14.0 ・ Glycerin 8.0 ・ Sodium carboxymethylcellulose 1.5 ・ Sodium lauryl sulfate 2.0-Saccharin sodium 0.1-Aluminum hydroxide 40.0-Benzethonium chloride 0.01-Fragrance 0.8-Water balance

Toothpaste 2 (Comparative Example 2) (% by weight) • Baking soda (average particle size 100 μm) 15.0 • Sorbitol 14.0 • Glycerin 8.0 • Sodium carboxymethylcellulose 1.5 • Sodium lauryl sulfate 2. 0 ・ Saccharin sodium 0.1 ・ Aluminum hydroxide 40.0 ・ Benzethonium chloride 0.01 ・ Fragrance 0.8 ・ Water balance

Toothpaste 3 (Example 1) (% by weight) ・ Special grade purified salt (average particle size 250 μm) 15.0 ・ Baking soda (average particle size 100 μm) 15.0 ・ Sorbitol 14.0 ・ Glycerin 8.0 -Sodium carboxymethyl cellulose 1.5-Sodium lauryl sulfate 2.0-Sodium saccharin 0.1-Aluminum hydroxide 40.0-Benzethonium chloride 0.01-Fragrance 0.8-Water balance

[0032]

[Table 1]

As is evident from the results shown in Table 1 above, the toothpaste 3 of the present invention (Example 1) is a toothpaste 1 containing no sodium bicarbonate (Comparative Example 1) and a toothpaste containing no sodium chloride. Compared to dentifrice 2 (Comparative Example 2), the effect of improving gingivitis is significantly higher.

Examples 2 to 4 and Comparative Examples 3 to 4 Toothpastes 4 to 8 having the following composition were prepared according to a conventional method. For each of the resulting toothpastes 4 to 8, ten panelists evaluated the tightness and saltiness of the gums according to the following criteria. The salivary concentration of benzethonium chloride (a bactericide) as a compounding component was measured by the following method. The results are shown in Table 2 below. Gums tightened Good: Feels tight. Normal: I feel a bit tight. Bad: I don't feel tight. Saltiness Good: Just good. Normal: slightly salty. Bad: salty and unpleasant. Method for measuring the concentration of benzethonium chloride in saliva After brushing 1 g of toothpaste with 1 g of toothpaste, 1 ml of saliva is collected from the oral cavity with a pipette, appropriately diluted with the following diluent, filtered, Perform a quantitative test by chromatographic method. Diluent: Acetonitrile and water are mixed at a ratio of 65:35. Using this solution as a solvent, a solution containing 0.03 M of sodium lauryl sulfate and 0.1 M of sodium perchlorate is prepared and used as a diluent.

Toothpaste 4 (Comparative Example 3) (% by weight) ・ Purified grade salt (average particle size 250 μm) 15.0 ・ Sorbitol 14.0 ・ Glycerin 8.0 ・ Sodium carboxymethyl cellulose 1.5 ・ Sodium lauryl sulfate 2.0-Saccharin sodium 0.1-Aluminum hydroxide 40.0-Benzethonium chloride 0.01-Fragrance 0.8-Water balance

Toothpaste 5 (Example 2) (% by weight) ・ Special grade purified salt (average particle size 250 μm) 15.0 ・ Baking soda (average particle size 100 μm) 20.0 ・ Sorbitol 14.0 ・ Glycerin 8.0 -Sodium carboxymethylcellulose 1.5-Sodium lauryl sulfate 2.0-Sodium saccharin 0.1-Aluminum hydroxide 20.0-Benzethonium chloride 0.01-Fragrance 0.8-Water balance

Toothpaste 6 (Example 3) (% by weight) • Special grade purified salt (average particle size 250 μm) 15.0 • Baking soda (average particle size 250 μm) 20.0 • Sorbitol 14.0 • Glycerin 8.0 -Sodium carboxymethylcellulose 1.5-Sodium lauryl sulfate 2.0-Sodium saccharin 0.1-Aluminum hydroxide 20.0-Benzethonium chloride 0.01-Fragrance 0.8-Water balance

Toothpaste 7 (Comparative Example 4) (% by weight) • Special grade purified salt (average particle size 250 μm) 20.0 • Sorbitol 14.0 • Glycerin 8.0 • Sodium carboxymethylcellulose 1.5 • Sodium lauryl sulfate 2.0-Saccharin sodium 0.1-Aluminum hydroxide 35.0-Benzethonium chloride 0.01-Fragrance 0.8-Water balance

Toothpaste 8 (Example 4) (% by weight) • Special-grade purified salt (average particle size 150 μm) 15.0 • Baking soda (average particle size 100 μm) 20.0 • Sorbitol 14.0 • Glycerin 8.0 -Sodium carboxymethylcellulose 1.5-Sodium lauryl sulfate 2.0-Sodium saccharin 0.1-Aluminum hydroxide 20.0-Benzethonium chloride 0.01-Fragrance 0.8-Water balance

[0040]

[Table 2]

As is clear from the results shown in Table 2 above, the toothpastes 5 and 6 of the present invention (Examples 2 and 3)
Satisfactory results were obtained for all evaluation items. In particular, salivary concentrations of benzethonium chloride have been kept high. On the other hand, the toothpaste 4 containing no baking soda (Comparative Example 3) was not effective in tightening the gums, and the toothpaste 7 in which only the salt concentration was increased without adding baking soda (Comparative Example 4)
Although the tightening effect on the gums is improved, the saltiness increases, and as a result, the salivary concentration of benzethonium chloride is greatly reduced. Regarding the salt particle size, the toothpastes 5, 6, and 8 (Examples 2, 3, and 4) of the present invention showed satisfactory results for all evaluation items.

Example 5 and Comparative Examples 5 to 6 Toothpastes 9 to 11 having the following composition were prepared according to a conventional method. For each of the obtained toothpastes 9 to 11, the gum tightness and saltiness were evaluated in the same manner as in Example 2. The concentration of chlorhexidine hydrochloride (a bactericide) in the saliva was measured by the following method. The results are shown in Table 3 below.・ Method for measuring the concentration of chlorhexidine hydrochloride in saliva After brushing 1 g of toothpaste with 1 g of toothpaste, 1 ml of saliva is collected from the oral cavity with a pipette, appropriately diluted with the following diluent, filtered, and then filtered. Perform a quantitative test by liquid chromatography. Diluent: A solution adjusted to pH 2.5 by adding phosphoric acid to a 0.05 M potassium hydrogen phosphate solution and acetonitrile are mixed at a ratio of 4: 6. Using this solution as a solvent, a solution containing 10 mM of sodium lauryl sulfate is prepared and used as a diluent.

Toothpaste 9 (Comparative Example 5) (% by weight) • Special-grade purified salt (average particle size 250 μm) 15.0 • Sorbitol 14.0 • Glycerin 8.0 • Sodium carboxymethylcellulose 1.5 • Sodium lauryl sulfate 2.0 ・ Saccharin sodium 0.1 ・ Aluminum hydroxide 40.0 ・ Chlorhexidine hydrochloride 0.01 ・ Fragrance 0.8 ・ Water balance

Toothpaste 10 (Example 5) (% by weight) ・ Special grade purified salt (average particle size 250 μm) 15.0 ・ Baking soda (average particle size 100 μm) 20.0 ・ Sorbitol 14.0 ・ Glycerin 8.0 -Sodium carboxymethyl cellulose 1.5-Sodium lauryl sulfate 2.0-Sodium saccharin 0.1-Aluminum hydroxide 20.0-Chlorhexidine hydrochloride 0.01-Fragrance 0.8-Water balance

Toothpaste 11 (Comparative Example 6) (% by weight) • Special grade purified salt (average particle size 250 μm) 20.0 • Sorbitol 14.0 • Glycerin 8.0 • Sodium carboxymethylcellulose 1.5 • Sodium lauryl sulfate 2.0 ・ Saccharin sodium 0.1 ・ Aluminum hydroxide 35.0 ・ Chlorhexidine hydrochloride 0.01 ・ Fragrance 0.8 ・ Water balance

[0046]

[Table 3]

As is clear from the results shown in Table 3 above, the toothpaste 10 of the present invention (Example 5) showed satisfactory results for all evaluation items. In particular, the salivary concentration of chlorhexidine hydrochloride is maintained at a high level.
On the other hand, the toothpaste 9 containing no baking soda (Comparative Example 5) was not effective in tightening the gums, and the toothpaste 11 (Comparative Example 6) in which only the salt concentration was increased without adding baking soda was used. The effect is improved, but the saltiness is increased, resulting in a significant decrease in the salivary concentration of chlorhexidine hydrochloride.

Example 6 The following gingival massage cream composition (gingival coating)
Was prepared according to a conventional method. The gingival massage cream composition was evaluated as having a moderate saltiness and a high gingivitis improving effect. Gum massage cream composition (% by weight)-Special grade purified salt (average particle size 250 m) 10.0-Baking soda (average particle size 250 m) 10.0-White petrolatum 5.0-Propylene glycol 4.0-PEG2000 20.0 (Polyethylene glycol: average molecular weight 2000) ・ PEG400 30.5 (polyethylene glycol: average molecular weight 400) ・ Cetanol 5.0 ・ Benzethonium chloride 0.02 ・ Fragrance 0.5 ・ Water Balance

[0049]

EFFECT OF THE INVENTION The oral composition of the present invention is excellent in the treatment and prevention of periodontal disease and has no unpleasant saltiness of salt.
Further, the present invention has the effect that the effective concentration of the fungicide in the oral cavity can be maintained at a high level without adding a high-concentration fungicide, and the taste and feel are good (claim 1). In addition, the oral composition of the present invention can further improve the above-described effects by using a salt having a specific average particle size and a sodium bicarbonate having a specific average particle size, and appropriately reducing saltiness in the oral cavity. And it can be kept constant (claims 2 and 4).
In addition, the oral composition of the present invention further enhances the above-mentioned effects by using a specific bactericide, or by including a specific ratio of salt and baking soda, or by including a specific amount of salt. It can be improved (claims 3, 5 and 6). The oral composition of the present invention can be suitably used as a dentifrice by adding a water-insoluble abrasive (claims 7 to 10). In addition, the oral composition of the present invention can be suitably used as a gingival coating agent by blending an oil component or a water-soluble polymer.
And 12).

──────────────────────────────────────────────────続 き Continuation of the front page (56) References JP-A-63-211218 (JP, A) JP-A-3-127718 (JP, A) JP-A-5-58865 (JP, A) JP-A-6-112 72834 (JP, A) Special Table 8-506098 (JP, A) (58) Fields surveyed (Int. Cl. ⁷ , DB name) A61K ^7/ 16-7/30

Claims (9)

(57) [Claims] 1. It contains the following component (a), component (b) and component (c), and the content of component (a) is 10 to 30.
% By weight, the weight ratio of the components (a) and (b)
(Or salt / baking soda) in the range of 1 / 0.5 to 1/3 . (A) Salt (b) Baking soda (c) Chlorhexidine salts and quaternary ammonium salts
One or more fungicides selected from the group consisting of 2. The component (a) having an average particle size of 150 to 4
The oral composition according to claim 1, which is a granular salt of 50 µm, and the component (b) is granular sodium bicarbonate having an average particle size of 45 to 450 µm. 3. An average particle size of the granular salt is 150 to 350 μm.
The oral composition according to claim 2, wherein m and the average particle size of the particulate baking soda are 100 to 300 µm. 4. The following components (a), (b) and (c)
Component and component (d), and the content of component (a) is 1
0 to 30% by weight, and the weight distribution of component (a) and component (b)
When the combined ratio (salt / baking soda) is in the range of 1 / 0.5 to 1/3
That the dentifrice. (A) Salt (b) Baking soda (c) Chlorhexidine salts and quaternary ammonium salts
One or more fungicides selected from the group consisting of: (d) water-insoluble abrasives 5. The component (a) having an average particle size of 150 to 4
The dentifrice according to claim 4 , which is a 50 µm granular salt, and the component (b) is a granular sodium bicarbonate having an average particle diameter of 45 to 450 µm. 6. The water-insoluble abrasive is one selected from the group consisting of silicic anhydride, hydrous silicic acid, calcium silicate, aluminum silicate, heavy calcium carbonate, light calcium carbonate, aluminum hydroxide and alumina. 5. The dentifrice according to claim 4 , wherein the dentifrice is at least two kinds. 7. The dentifrice according to claim 4 , wherein the water-insoluble abrasive is aluminum hydroxide. 8. The following components (a), (b) and (c)
Component and component (e), and the content of component (a) is 1
0 to 30% by weight, and the weight distribution of component (a) and component (b)
When the combined ratio (salt / baking soda) is in the range of 1 / 0.5 to 1/3
Gum coating agent that. (A) Salt (b) Baking soda (c) Chlorhexidine salts and quaternary ammonium salts
One or more fungicides selected from the group consisting of: (e) oily components or water-soluble polymers 9. The component (a) having an average particle size of 150-4.
The gingival coating composition according to claim 8 , which is a 50 µm granular salt, and the component (b) is a granular sodium bicarbonate having an average particle size of 45 to 450 µm.