JP3231479B2 - Solid dialysis drug dissolution equipment - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an apparatus capable of automatically preparing a dialysate having a predetermined concentration from a solid dialysate for use in hemodialysis. The present invention relates to an apparatus for dissolving a solid dialysis drug that can smoothly perform processing of a container in which the drug is sealed, that is, an empty container, while performing a dissolution process.

[0002]

2. Description of the Related Art At present, dialysate adjusting agents are commercially available as concentrated solutions or partially powdery or granular solid agents, which are appropriately dissolved in dilution water to adjust the concentration and used as a dialysate. Is done.

As this kind of dialysate, a bicarbonate type and an acetic acid type are used. Hereinafter, the bicarbonate type will be described. In the bicarbonate dialysate, an agent containing sodium bicarbonate (hereinafter referred to as agent A) from the viewpoint of storage stability.
And a drug that does not contain sodium bicarbonate (hereinafter referred to as drug B). It is to be noted that solidification of the dialysis drug is particularly frequently performed with a bicarbonate-based B agent.

[0004] When a dialysate is prepared from a solid dialysate, usually, the drug is first dissolved and mixed in water to form a concentrated solution.
The concentrated solution is supplied to a dialysate adjusting device and further mixed with water to adjust the dialysate, or directly dissolved as a dialysate.

However, in a dialysate adjusting apparatus for supplying a dialysate to a plurality of dialysers, a method of dissolving and mixing a solid dialysis drug in water has conventionally required a method for each dialysis performed simultaneously. The amount of water necessary to make a concentrated solution to be stored is stored in a predetermined tank, and a plurality of containers containing solid dialysis drugs (often in a transparent bag) are manually opened, and then the drugs are stored in a tank. In general, the mixture is charged, and mechanically stirred by a stirrer (stirring blade) or the like provided in the tank to dissolve and mix.

Normally, such a dissolving and mixing operation is not performed in a clean atmosphere such as a clean room, so that there are many opportunities for bacteria and dust in the air to come into contact with the dialysate and the concentrated liquid after dissolution. In addition, there are many opportunities for humans to touch the container containing the dialysis drug when opening or loading the container, which is problematic in terms of hygiene. Also, leaving the concentrated solution after dissolution mixing for a long time, or dissolving and leaving it on the day before use for dialysis, because there is a possibility that the concentration of the concentrated solution may change as well as hygiene, Not desirable. In particular, a concentrated solution of sodium bicarbonate has low stability and is hardly preserved, so it is necessary to dissolve and use it during dialysis.
For this reason, the dissolution / mixing operation must be performed during a busy time period before the start of dialysis, which places a heavy burden on persons engaged in dialysis. Further, even after the completion of dialysis, many operations such as disposal of excess concentrated liquid and washing of the tank are required.

From such a viewpoint, a labor-saving sodium bicarbonate continuous dissolution apparatus which continuously and automatically dissolves sodium bicarbonate and does not require any manual operation has been proposed (Japanese Patent Publication No. Hei 1-101). 55893). This continuous dissolving apparatus supplies sodium bicarbonate by a powder supply means such as a powder feeder and water by a water supply means to the stirring tank, and supplies the powder supply means or the water supply means according to the concentration after stirring. By controlling and dispensing sodium bicarbonate or water, a concentrated solution of sodium bicarbonate is obtained.

[0008]

However, in the sodium bicarbonate continuous dissolution apparatus proposed above, for example, a container containing sodium bicarbonate necessary for one dialysis is opened, and then powder supply means is provided. Requires the work to be put into a storage container such as a hopper which communicates with the hopper. In this case, since the sodium bicarbonate and the storage container are in contact with air for a long time, there is a problem in terms of sanitation.
Further, in this case, cleaning of the powder supply means and the like,
Regarding automation or labor saving regarding disinfection processing,
Nothing has been proposed.

The amount of such a solid dialysis agent used is, for example, in the case of a bicarbonate system, the average amount of the solid dialysis agent containing sodium bicarbonate (agent A) per patient (dialysis time: 5 hours). 323 g (approximately 0.4 liter: apparent specific gravity varies depending on the powder or granular state of the solid dialysis drug), and 1270 g (approximately 1.6 liter) of the solid dialysis drug (agent B) containing no sodium bicarbonate.

In determining the unit volume of the container for the solid dialysis drug, it is necessary to consider its use form. Once dissolved, this drug cannot be preserved due to bacterial growth and the like. For this reason, in a single-use device, it is necessary to dissolve one patient at a time, and in consideration of variations in dialysis time, it is necessary that the container can be filled with at least twice as much medicine as the average usage per patient. .

On the other hand, in a multi-person dialysate supply device, dialysate must be supplied simultaneously to, for example, 20 patient monitoring devices. For this reason, if containers having a volume suitable for single use or various multi-person devices are prepared, the types of containers increase, and the number of containers to be stored in hospitals increases, which is complicated.

Therefore, in general, the volume of a solid dialysis drug container that can be filled with twice as much drug as the average usage per patient (ie, 1 liter and 3.5 liters, respectively)
L) plastic bottles are used.
Therefore, in the dissolving device for the dialysate supply device for 20 persons, the two types of containers of the agent A and the agent B are each stored for 1 hour in 5 hours
It is consumed at a rate of 0 pieces (two pieces in 30 minutes) (an empty container is generated). However, processing a large number of empty containers generated in this case every day or every several days imposes on the hospital side space and work for storing such processing. Cause problems.

Accordingly, an object of the present invention is to eliminate the need to manually operate and insert a container in which a solid dialysis drug is enclosed when preparing a dialysate from a powdery or granular solid dialysis drug. The time required for the dialysis drug to come into direct contact with the unclean air is minimized, and a dialysate having a predetermined concentration can be prepared in an automatic, sanitary, and labor-saving manner. It is an object of the present invention to provide a device for dissolving a solid dialysis drug which can easily and easily perform the treatment of the container.

[0014]

The apparatus for dissolving a solid dialysis drug according to the present invention comprises a plastic container containing a fixed amount of a powdered or granular solid dialysis drug.
In a solid dialysis drug dissolving apparatus configured to supply dilution water for dissolving the solid dialysis drug, mix the solid dialysis drug in the container with the dilution water, and store the mixture in a dissolution tank, Two types of containers each containing a fixed amount of the solid dialysis drug are disposed on concentric circles separated by a predetermined distance in the radial direction, and container transfer means set so as to sequentially transfer them in the direction of rotation of the concentric shaft, At a predetermined position of the container transfer unit, a fixed-quantity water supply unit for supplying a fixed amount of dilution water to each of the two types of containers, and a liquid sending device that sends a solid dialysis drug mixed with the dilution water to the dissolution tank by the fixed-quantity water supply unit. Means, and empty container transfer means for removing the empty container from the container transfer means and transferring the empty container to the processing means.

[0015]

According to the solid dialysis drug dissolving apparatus of the present invention, containers in which two kinds of powdered or granular solid dialysis drugs are respectively sealed are concentrically separated by a predetermined distance in the radial direction by container transfer means. Arrange them one by one,
This is sequentially transported in the direction of rotation of the concentric shaft, and a predetermined amount of dilution water is supplied from a quantitative water supply means at a predetermined position to the pair of solid dialysis drug containers, and the drug is sequentially stored in a dissolution tank while dissolving the drug. As a result, a dialysate having a predetermined concentration can be easily and automatically prepared by a sanitary and labor-saving apparatus. At this time, the empty containers in which the solid dialysis drug has been consumed are properly taken out by the empty container take-out means, and then transferred to the means for processing the empty containers via the empty container transfer means, so that these empty containers are removed. It can be processed simply and easily.

The means for processing the empty container is not particularly limited, and may be any of various known processing apparatuses, as long as it does not deteriorate the atmosphere by generating noise, odor, heat and the like. it can. Therefore, as an empty container processing means of this kind, for example, a device for melting and pelletizing an empty container made of plastic, a rotary cutting machine for cutting and pulverizing an empty container by two rollers provided with circular blades meshing with each other ( JP-A-3-213959), a configuration in which a projection is provided on a circular blade of the rotary cutting machine so that the edge of the empty container is hooked and the empty container is drawn in, or an ultrasonic cutter (Japanese Patent Publication No. 63-61106). No., JP-A-5
In addition, a press or the like that compresses an empty container under heating at a relatively low temperature can be used.

Further, the empty container transfer means can be constituted by appropriately combining known automatic devices. In this case, it is possible to assemble an industrial robot for continuously transferring empty containers to the empty container processing means together with the empty container taking out means for taking out empty containers by the container transferring means.

[0018]

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a block diagram showing a solid dialysis drug dissolving apparatus according to an embodiment of the present invention.

First, the basic principle of the solid dialysis drug dissolving apparatus according to the present invention will be described with reference to FIG. That is, in FIG. 1, reference numeral 1 denotes a container in which a powder or granular solid dialysate preparation agent is quantitatively sealed, and reference numeral 2 stores a solution obtained by dissolving the solid dialysate. 3 shows a dissolution tank. However, in the present invention, diluting water is supplied to the solid dialysis drug in the container 1 to dissolve the solid dialysis drug, and the obtained solution of the dialysis drug is stored in the dissolution tank 2 and mixed and dissolved. Water supply means 3 is provided. In this case, the container 1 and the dissolving tank 2 are connected to each other to form a circulation system for the dilution water or the dissolving solution. Therefore, the water supply means 3 is connected to supply a predetermined amount of dilution water to the dissolution tank 2 in advance (shown by a solid line), or is connected to directly supply dilution water to the container 1 (shown by a broken line). )be able to.

As an alternative, diluting water is supplied from the water supply means 3 directly to the solid dialysate in the container 1 to dissolve the solid dialysate, and the obtained solution of the dialysate is sequentially put into the dissolution tank 2. It can also be configured to store and not to circulate the solution (indicated by the dashed line).

As described above, according to the present invention, the means for supplying a constant amount of the dialysis drug to the dissolution tank as in the prior art is omitted, and the dilution water is directly supplied to the enclosure of the solid dialysis drug. The dialysis drug in the container is transferred to and stored in the dissolution tank, and a solution of the dialysis drug having a predetermined concentration can be easily and hygienically prepared.

Next, an embodiment of the apparatus according to the present invention having an improved means for supplying the container will be described in detail.

FIG. 2 is a schematic system diagram showing an embodiment of the apparatus for dissolving a solid dialysis drug according to the present invention. In FIG. 2, reference numerals 10 and 12 denote containers in which two types of solid dialysis agents are respectively enclosed, and reference numeral 14 denotes a turntable on which these containers 10 and 12 are mounted and rotated. In this turntable 14, the two types of containers 10, 12 are:
The concentric circles a and b that are separated by a predetermined distance in the radial direction are set so as to correspond to each other one by one. in this case,
The turntable 14 is positioned at a predetermined position P1 so as to supply the pair of containers 10 and 12 with dilution water. For this reason, the pair of containers 10 and 12 are always kept in a fixed state at the predetermined position P1.
A container transfer means 16 is provided so as to intermittently turn the turntable 14.

Accordingly, the container transfer means 16 includes a rotation driving device 18 for turning the turntable 14 and a control for controlling the rotation driving device 18 for intermittently turning the turntable 14 at a predetermined angular position. And an apparatus 20.

Further, on the turntable 14, the pair of containers 10, 12 is located at a position P2 which is one position before the predetermined position P1 where the pair of containers 10, 12 is positioned.
, Sensors 22 and 24 using, for example, a photoelectric conversion element or the like, which can detect the presence or absence of a container in which a solid dialysis drug is sealed are provided, and the detection outputs of these sensors 22 and 24 are input to the control device 20. Then, the rotary drive device is controlled such that an appropriate container in which the solid dialysis drug is sealed is always located at the predetermined position P1. That is, if any of the sensors 22 and 24 fails to detect a container or detects an empty container,
The intermittent turning movement of the turntable 14 is performed until an appropriate container is detected. The sensor 2
Opening means 26 for opening the sealing material for sealing the mouth of the container can be provided corresponding to the position where the containers 2 and 24 are provided.

Further, on the turntable 14, the solid dialysis drug is consumed at a position P3 behind the predetermined position P1 where the pair of containers 10, 12 are positioned, facing the pair of containers 10, 12, respectively. An empty container removing means 90 for removing the empty container is provided. in this case,
In order to properly take out only empty containers, sensors using a photoelectric conversion element or the like are provided at each of the positions P3 in the same manner as described above, and the detection outputs of these sensors are appropriately input to a control device, and the empty container is taken out. The means 90 can be configured to operate individually on each of said pair of containers 10,12. In this way, the empty container taken out from the turntable 14 by the empty container taking out means 90 is configured to be transferred to an empty container processing means described later.

The predetermined position P of the turntable 14
Container connection means 28 and 30 are provided for the pair of containers 10 and 12 positioned at 1 to be detachably attached to the mouths of the containers 10 and 12 when the dilution water is supplied in a fixed amount. On the other hand, dissolution tanks 32 and 34 are provided corresponding to the container connection means 28 and 30, respectively.
2 and 34 and the container connecting means 28 and 30
6 and 38 are connected to each other to form a circulation system of the dilution water or the solution for each of the containers 10 and 12. In this case, circulating pump devices 40 and 42 are provided in a part of the flow path means 36 and 38. Further, the flow path means 36, 38
Are connected to the dissolution tanks 32 and 34 via the on-off valves 48 and 50, respectively.

The dissolution tanks 32 and 34 are connected to one ends of discharge pipes 52 and 54 for discharging a solution obtained by dissolving the stored solid dialysate with diluting water. The other ends of the discharge pipes 52 and 54 are connected to the mixing and dissolving tanks 60 via on-off valves 56 and 58, respectively, to dilute and dissolve the two types of solid dialysis drugs obtained in the dissolving tanks 32 and 34. The liquid is mixed so that a dialysate having a predetermined concentration can be prepared.

FIG. 3 shows a specific arrangement of the container 10 (12) and the container connecting means 28 (30) in the embodiment shown in FIG. In FIG. 3, only the correspondence between one container 10 and one dissolution tank 32 will be described.
The corresponding relationship with the other dissolving tank 34 has the same configuration. The same components as those shown in FIG. 1 are denoted by the same reference numerals, and detailed description thereof will be omitted.

In FIG. 3, the container 10 is formed of a polyethylene container molded into a cylindrical shape by, for example, a blow molding method, and the circular mouth is closed with a similar polyethylene film to determine the amount of the solid dialysis drug therein. Consists of a sealed one. At the mouth of the container 10, one end of a flow path means 36, which communicates with the dissolving tank 32 via a sealing member as appropriate, is attached. Extension pipes 62 and 64 having
Is connected. The container connecting means 28 thus configured is configured to be able to move up and down using an appropriate driving means above the container 10 stopped at a predetermined position P of the turntable 14.

Next, the operation of the embodiment shown in FIGS. 2 and 3 will be described.

First, two types of containers 10 and 12 are held at predetermined positions on the turntable 14, respectively. In this case, the sealing material of the containers 10 and 12 is opened in advance and placed on the turntable 14 or placed on the turntable 14 in an unopened state, and an appropriate opening means is provided at any position. Shall be opened at

Next, the turntable 14 moves,
Appropriate container 1 in which solid dialysis drug is sealed in predetermined position P1
When 0 and 12 are respectively positioned, each container 10, 1
As shown in FIG. 3, the container connecting means 28 and 30 are set in a liquid-tight manner with respect to the mouth portions 2 respectively. Next, on-off valve 4
8, 50 are opened to supply a fixed amount of dilution water into the dissolution tanks 32, 34 from the fixed amount water supply means 44, 46.
Close 8,50. Thereafter, the pump devices 40 and 42 provided in the flow path means 36 and 38 are driven to drive the dissolving tank 3
2 and 34 are supplied into the containers 10 and 12, respectively, and the solid dialysis drug in the containers 10 and 12 is sequentially discharged while being dissolved in the dilution water. Can be stored. In the dissolving step of the dialysis drug, the operation time can be set to be constant using, for example, a timer. The dissolving liquid stored in the dissolving tanks 32, 34 is supplied to the pump device 40,
By circulating between the containers 10 and 12 through 42, the mixture is automatically stirred and mixed.

In this manner, each of the melting tanks 32,
The dialysis solution of a predetermined concentration stored in the dialysis solution is supplied to the mixing and dissolving tank 60 by opening the on-off valves 56 and 58 of the discharge pipes 52 and 54, respectively. Can be prepared. In the present embodiment, a concentration meter for measuring the dilution concentration of the dialysis drug is provided in each of the dissolution tanks 32 and 34, and the concentration is checked when the dissolution process is completed. It is also possible to set to discard from the system.

In the embodiment shown in FIG. 3, a pump device 40 is provided in the flow path means 36 led out from the bottom of the dissolving tank 32. The container connecting means 28 of the container 10
Connected to An opening / closing valve 66 and a float switch 68 are provided in a part of the flow path means 36. 74
For communication. Further, a return pipe 78 is connected to a connection portion between the on-off valve 66 of the flow path means 36 and the float switch 68 via an on-off valve 76 from the throat of the venturi pipe 72. The discharge pipe 52
A mixing and dissolving tank 60 is connected via an on-off valve 56 to the downstream side of the tank. In addition, at the bottom of the mixing and dissolving tank 60,
A discharge pipe for discharging the stored mixed liquid is connected via an on-off valve, and a waste pipe for discarding excess stored mixed liquid is connected to the discharge pipe appropriately via an on-off valve. Is done. The mixing and dissolving tank 6
0 and the upper part of the dissolving tank 32
Connect by 0.

According to the embodiment shown in FIG. 3, first, only the on-off valve 48 is opened, and a predetermined amount of water is supplied from the fixed amount water supply means 44 to the dissolution tank 32. Next, by closing the on-off valve 48 and driving the pump device 40, the water in the dissolving tank 32 flows into the container 10 via the flow path means 36. At this time, the inflowing water flows back to the dissolution tank 32 through the flow path means 36 while dissolving the solid dialysis drug fixedly enclosed in the container 10. Therefore, by continuously driving the pump device 40, the liquid in the dissolving tank 32 circulates through the vessel 10 and the dissolving tank 32
The mixed dissolution of the dialysis drug is performed in the inside.

In this embodiment, the on-off valve 6
When the valve 6 is closed and the on-off valve 70 is opened, the liquid in the dissolution tank 32 circulates through the flow path means 36 and the communication pipe 74. At this time, a negative pressure is generated in the return pipe 78 connected to the throat of the Venturi pipe 72 by the action of the Venturi pipe 72 provided in the communication pipe 74 (Bernoulli's theorem). Therefore, in this case, when the on-off valve 76 provided on the return pipe 78 is opened, the solution remaining in the container 10 can almost flow into the dissolution tank 32 through the flow path means 36 and the return pipe 78. .

When most of the solution remaining in the container 10 flows into the dissolution tank 32, the float switch 68 is operated, and after a certain period of time, the open / close valves 70 and 76
Is closed, the driving of the pump device 40 is stopped, and the mixing and dissolution of the dialysis drug in the dissolution tank 32 is completed. After the concentrated liquid having a predetermined concentration is formed in the dissolving tank 32 in this manner, the liquid in the dissolving tank 32 is transferred to the mixed dissolving tank 60 by opening the on-off valve 56 of the discharge pipe 52. At this time, the transfer time can be reduced by appropriately driving the pump device 40.

When the mixing and dissolving of the dialysate in the dissolution tank 32 is completed in this manner, the mixing and dissolving of the dialysate described above is repeated again in the container in which a new solid dialysate is sealed. For this reason, the turntable 14 moves and shifts to the next operation cycle. In this case, when the empty containers having consumed the solid dialysis drug are detected at the predetermined position P3 and are taken out by the empty container taking out means 90, these empty containers are appropriately transferred to the empty container processing means by the empty container transferring means. Is done.

However, as the empty container processing means,
As long as it does not generate noise, odor, heat, or the like, various known processing apparatuses can be applied without particular limitation. However, in this case, for example, an apparatus in which a plastic empty container is melted and pelletized is also effective, but in the present invention, since the container is taken out only intermittently, the operation rate of the apparatus only decreases. Not
It is not preferable because it is uneconomical to maintain the temperature of the processor and the apparatus becomes large. On the other hand, for example, the container is cut and cut by a circular blade provided so as to mesh with two roller means.
A rotary cutting machine or an ultrasonic cutter configured to pulverize can be suitably used.

The empty container transfer means can be constituted by appropriately combining known automatic devices. In this case, it is possible to assemble an industrial robot for continuously transferring empty containers to the empty container processing means together with the empty container taking out means for taking out empty containers by the container transferring means.

The preferred embodiment of the present invention has been described above. However, the present invention is not limited to the above-described embodiment, and various design changes can be made without departing from the spirit of the present invention. Of course.

In the above description, the bicarbonate system in which both the agent A and the agent B are solid has been described. However, only one of them may be solid or acetic acid. There is no.

Further, in the above-described embodiment, the case where the fixed-quantity water supply means is directly connected to the dissolving tank is shown.
This fixed-quantity water supply means may be connected and arranged at any position of the flow path means. In addition, the flow path means should be configured such that the quantitative water supply means is directly connected to the container and the solution of the solid dialysis drug is unilaterally recovered from the container to the dissolution tank without removing the pump device and forming a circulation system. Can also. Further, the case has been shown in which the containers are placed with their mouths facing upward on a turntable as the container transfer means, but these containers may be placed with their mouths facing downward.

[0045]

As is clear from the above-described embodiment, according to the present invention, the container containing the solid dialysis drug is simply set at a predetermined position of the container transfer means, and then the solid dialysis in the container is automatically performed. The drug can be dissolved and stored in a predetermined dissolution tank, and a dialysate consisting of a predetermined concentration and a predetermined component can be easily prepared. Therefore, it is possible to omit the manual operation such as the opening of the container and the introduction of the medicine as in the related art, and the time during which the dialysis medicine is in contact with the outside air is also short,
The dissolution of the solid dialysis drug and the mixing operation thereof can be achieved extremely hygienically. In addition, empty containers in which the solid dialysis drug has been consumed can be properly taken out by the empty container taking out means, and processing of these empty containers can be achieved simply and easily.

[Brief description of the drawings]

FIG. 1 is a schematic system diagram showing the basic principle of an apparatus for dissolving a solid dialysis drug according to the present invention.

FIG. 2 is a schematic system diagram showing one embodiment of a solid dialysis drug dissolution apparatus according to the present invention.

FIG. 3 is an explanatory diagram showing a configuration and a schematic system of a relationship between a container of a dissolving device for a solid dialysis drug shown in FIG. 2, a container connecting means, and a dissolving tank.

DESCRIPTION OF SYMBOLS 1 container 2 dissolution tank 3 water supply means 10, 12 container 14 turntable 16 container transfer means 18 rotation drive device 20 control device 22, 24 sensor 26 opening means 28, 30 container connection means 32, 34 dissolution tank 36 , 38 Flow path means 40, 42 Pump device 44, 46 Fixed water supply means 48, 50 Open / close valve 52, 54 Discharge pipe 56, 58 Open / close valve 60 Mixing / melting tank 62, 64 Extension pipe 66 Open / close valve 68 Float switch 70 Open / close valve 72 Venturi pipe 74 Communication pipe 76 Open / close valve 78 Return pipe 80 Communication pipe 90 Empty container removal means P1 Connection position with circulating system of dissolved liquid etc. P2 Detection position of drug filled container P3 Empty container removal position

──────────────────────────────────────────────────続 き Continuation of front page (56) References JP-A-5-146487 (JP, A) JP-A-4-84967 (JP, A) JP-A-6-285137 (JP, A) JP-A-57- 159529 (JP, A) JP-A-4-61865 (JP, A) JP-A-3-66621 (JP, A) JP-A-4-300637 (JP, A) (58) Fields investigated (Int. Cl. ⁷ , DB name) A61M 1/14 A61J 3/00

Claims (1)

(57) [Claims] 1. A diluting water for dissolving a solid dialysis drug is supplied to a plastic container in which a powdered or granular solid dialysis drug is filled in a fixed amount, and the solid dialysis drug in the container is mixed with the diluting water. In a solid dialysis drug dissolution apparatus configured to mix and store the mixed solution in a dissolution tank, two types of containers each of which is fixedly filled with two types of solid dialysis drugs are concentric circles spaced apart by a predetermined distance in the radial direction. A container transfer means which is arranged above and is set so as to sequentially transfer it in the direction of rotation of the concentric axis; and a fixed amount for supplying a fixed amount of dilution water to each of the two kinds of containers at a predetermined position of the container transfer means. A water supply means, a liquid supply means for sending a solid dialysis agent mixed with dilution water by the constant-rate water supply means to a dissolution tank, and an empty container taken out from the container transfer means. Dissolution apparatus solid dialysis agent, characterized in that providing the empty container transfer means for transferring the means for processing the containers.