JP3144895B2 - Medical adhesive tape or sheet - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a medical pressure-sensitive adhesive tape or sheet having a pressure-sensitive adhesive layer provided on one side of a support, and more particularly to a medical pressure-sensitive adhesive tape or sheet which imparts moisture permeability during application without impairing the adhesiveness. The present invention also relates to a low-irritation medical pressure-sensitive adhesive tape or sheet having little physical irritation such as scalp and exfoliation of the skin during peeling.

[0002]

2. Description of the Related Art Generally, medical pressure-sensitive adhesive tapes or sheets for medical plasters, bandages, surgical dressings, and the like are prepared by blending a rubber elastic material such as natural rubber or polyisoprene rubber, a tackifying resin, and a softener as a pressure-sensitive adhesive. Using a rubber-based pressure-sensitive adhesive. However, a medical pressure-sensitive adhesive tape or sheet having a pressure-sensitive adhesive layer mainly composed of such a rubber elastic body has excellent adhesiveness at the time of application, but has a horny layer of skin due to its strong adhesive strength at the time of peeling. It exfoliated, leading to hair swelling and lack of moisture permeability, causing skin irritation and irritation.

Therefore, as a method of reducing irritation to the skin, a medical adhesive tape or sheet having the following configuration has been proposed.

For example, Japanese Patent Publication No. 54-44688 discloses a water-soluble polyol such as propylene glycol, butylene glycol, hexylene glycol, polyethylene glycol having a molecular weight of 1,000 or less, glycerin and sorbitol, and a water-soluble or water-swellable high water-soluble polyol. It has been proposed to mix molecules with a rubber-based pressure-sensitive adhesive.
Japanese Patent No. 7069 discloses a water-absorbing polymer that absorbs water at least ten times its weight and gels and swells (for example, a water-soluble polymer obtained by introducing a cross-linking bond, specific examples: Sanyo Chemical Co., Ltd., Sunwet IM) -300, Sunwet IM-1000
It has been proposed to mix MPS) with a rubber-based pressure-sensitive adhesive.

[0005]

As described above, a medical pressure-sensitive adhesive tape or sheet using a rubber-based pressure-sensitive adhesive has a problem of rash and skin irritation due to stuffiness at the time of application. In addition, when a water-soluble polyol is blended with a rubber-based pressure-sensitive adhesive as described above, there is a drawback that the polyol bleeds from the rubber-based pressure-sensitive adhesive due to poor compatibility between the two.
Furthermore, when a water-absorbing polymer is added to the rubber-based adhesive, there is a problem that the water-absorbing polymer absorbs water during application and does not repel water. Was.

An object of the present invention is to provide a low-irritation moisture-permeable medical pressure-sensitive adhesive tape which alleviates skin irritation by imparting moisture permeability to the rubber-based adhesive without impairing the adhesiveness of the rubber-based adhesive. Is to provide a sheet.

[0007]

Means for Solving the Problems The inventors of the present application have made intensive studies to overcome the above-mentioned problems in the conventional medical pressure-sensitive adhesive tapes or sheets, and as a result, have found that a specific rubber-based pressure-sensitive adhesive has a water-soluble polymer and a polyvalent. By blending the required amount of the fatty acid ester of the alcohol, the compatibility of these compounds with the pressure-sensitive adhesive is good, and the pressure-sensitive adhesive has a moisture-absorbing ability, so that moisture permeability can be imparted. For medical adhesive tapes, there is almost no physical irritation such as shavings and exfoliation of the skin by blending a specific paraffinic and / or naphthenic hydrocarbon and a tackifying resin into a styrenic thermoplastic elastomer. Alternatively, the present inventors have found that a sheet can be obtained, and have completed the present invention.

That is, the medical pressure-sensitive adhesive tape or sheet according to the present invention is a medical pressure-sensitive adhesive tape or sheet in which a pressure-sensitive adhesive layer is provided on one surface of a support, wherein the pressure-sensitive adhesive layer is an ABA-type block. 5 to 25% by weight of a styrene-based thermoplastic elastomer made of a polymer and having 10 carbon atoms
A rubber-based pressure-sensitive adhesive containing 75 to 95% by weight of a paraffinic and / or naphthenic hydrocarbon and a tackifier resin, and a water-soluble polymer compounded in the pressure-sensitive adhesive layer.
0% by weight and fatty acid ester of polyhydric alcohol 2-3
0% by weight.

Hereinafter, each component of the anti-inflammatory and analgesic medical pressure-sensitive adhesive tape or sheet according to the present invention, its production method, and the like will be described in detail.

A) A which is one component of the rubber-based pressure-sensitive adhesive
As a styrene-based thermoplastic elastomer composed of a -BA type block copolymer, a styrene-isoprene-styrene block copolymer (solution viscosity: 300 to 2,000 c.
P (25 wt% toluene solution); styrene / rubber weight ratio: 14 / 86-21 / 79), styrene-butadiene-styrene block copolymer (solution viscosity: 220-40)
0cP (25% by weight toluene solution); styrene / rubber weight ratio: 28/72 to 50/50), styrene-ethylene / butylene-styrene block copolymer (solution viscosity: 2)
00 to 1500 cP (20% by weight toluene solution); styrene / rubber weight ratio: 13/87 to 30/70).

The proportion of the styrene thermoplastic elastomer in the rubber pressure-sensitive adhesive is 5 to 25% by weight. This ratio is 5
When the amount is less than the weight%, the cohesive force of the rubber-based pressure-sensitive adhesive is low, so that sufficient adhesiveness cannot be obtained, and adhesive residue or the like occurs at the time of peeling. On the other hand, if the proportion of the styrene-based thermoplastic elastomer in the rubber-based pressure-sensitive adhesive is more than 25% by weight, the adhesive strength of the rubber-based pressure-sensitive adhesive becomes too strong, so that repeated application cannot be performed, and exfoliation and scalping during peeling may occur. It causes irritation.

The paraffinic and / or naphthenic hydrocarbons having 10 to 30 carbon atoms used in the present invention include light liquid paraffin, heavy liquid paraffin, hexamethyltetracosane, hexamethyltetracosahexane, α -Olefin oligomers, etc., which are used alone or in combination of two or more.

Paraffinic hydrocarbons and / or naphthenic hydrocarbons having 31 or more carbon atoms are solid at room temperature and do not have sufficient softening properties when compounded with a tackifier resin or a styrene-based thermoplastic elastomer. A patch having good adhesive strength cannot be obtained. Those having 9 or less carbon atoms are not preferred because the softening property is increased and the pressure-sensitive adhesive layer becomes too soft.

The tackifying resin used in the present invention includes rosin resins (rosin, hydrogenated rosin, esters thereof and the like), polyterpene resins, cumarone-isodene resins, and petroleum resins (aliphatic and alicyclic resins). ), A softening point of at least 50 selected from the group of terpene-phenol resin, etc.
130 ° C. are exemplified.
Used in combination above. Above all, alicyclic hydrocarbon resin of petroleum resin (softening point of 65 to 130 ° C), glycerin ester of hydrogenated rosin (softening point of 80 to 130 ° C),
Polyterpene resins (softening point 80 to 130 ° C.) are preferred.

The mixing ratio of the tackifier resin is appropriately determined so that the adhesive force at the time of application and the scalping at the time of peeling do not occur. The petroleum resin by cationic polymerization in the presence of a generally Friedel-Crafts type catalyst such as di-olefins and mono-olefins contained in the C ₅ fraction and C ₉ fraction obtained in the naphtha cracking Those manufactured and having a molecular weight of 500 to 2,000 are preferably used.

In a further preferred embodiment of the medical pressure-sensitive adhesive tape or sheet according to the present invention, the paraffinic hydrocarbon and / or the naphthenic hydrocarbon and the tackifying resin are in a weight ratio of 2: 3 to 3: 2. Be blended. The reason is that when the weight ratio of the paraffin-based hydrocarbon and / or the naphthenic-based hydrocarbon to the tackifying resin is more than 3: 2, the tackiness becomes insufficient or the adhesive residue easily occurs after peeling. And conversely, the weight ratio is 2: 3
If it is smaller than the above, swelling may occur at the time of peeling,
This is because the stratum corneum of the skin peels off and skin irritation easily occurs.

Examples of the water-soluble polymer to be incorporated in the pressure-sensitive adhesive layer include methyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, hydroxyethyl cellulose, carboxymethyl cellulose, sodium carboxymethyl cellulose, crystalline cellulose.
Water-soluble cellulose derivatives such as carboxymethylcellulose narium, starch or starch such as starch, pregelatinized starch, dextrin, cyclodextrin, pullulan, hydroxypropyl starch, sodium carboxymethyl starch, or derivatives thereof, polyvinylpyrrolidone, carboxyvinyl polymer, polyvinyl alcohol, etc. And water-soluble natural polymers such as gum arabic, sodium alginate, propylene glycol alginate, xanthan gum, gelatin and the like.

The particle size of the water-soluble polymer is 500 μm or less in order to obtain a uniform dispersion when compounded in the pressure-sensitive adhesive solution.
More preferably, it is 200 μm or less.

The compounding amount of the water-soluble polymer is 2 in the pressure-sensitive adhesive layer.
３０30% by weight. If the amount is less than 2%, the patch may not have sufficient moisture permeability, and if the amount is less than 30%,
If the content is more than 10% by weight, problems such as difficulty in compounding the composition into the pressure-sensitive adhesive and poor sticking properties arise. In order to ensure proper moisture permeability and sticking property, the amount of the water-soluble polymer is preferably 4
２５25% by weight.

The fatty acid ester of the polyhydric alcohol compounded in the pressure-sensitive adhesive layer is compatible with the rubber-based pressure-sensitive adhesive, and specific examples thereof include sorbitanca plate, sorbitan laurate, sorbitan palmitate, and the like. Sorbitan stearate, sorbitan fatty acid esters such as sorbitan oleate, glycerin caprate, glycerin myristate, glycerin stearate, glycerin monooleate, decaglycerin laurate, decaglycerin myristate, decaglycerin stearate, decaglycerin oleate, Diglyceryl stearate, diglyceryl oleate, tetraglyceryl stearate, tetraglyceryl oleate, hexaglyceryl stearate, hexaglyceryl oleate, hexaglyceryl myristate Glycerin fatty acid esters such as hexaglyceryl laurate, propylene glycol fatty acid esters such as propylene glycol stearate, polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan stearate, and polyoxyethylene glycerin fatty acid esters such as polyoxyethylene glyceryl oleate And polyethylene glycol fatty acid esters such as polyethylene glycol stearate.

The amount of the fatty acid ester of the polyhydric alcohol is 2 to 30% by weight in the pressure-sensitive adhesive layer. If the amount is less than 2%, sufficient moisture permeability cannot be obtained for the patch, while if the amount exceeds 30% by weight, it may bleed from the pressure-sensitive adhesive layer or have poor sticking properties. Problems arise. In order to ensure appropriate moisture permeability and sticking property, the compounding amount of the fatty acid ester of the polyhydric alcohol is preferably 4 to 25% by weight. In this way, by allowing the water-soluble polymer and the fatty acid ester of the polyhydric alcohol to be contained in the pressure-sensitive adhesive layer, sufficient adhesiveness to the patch can be obtained. The moisture permeability is
60 g / m ² · 24 hr. If it is less than 60 g / m ² · 24 hr. More and I
It is configured to be.

B) The medical pressure-sensitive adhesive tape or sheet according to the present invention is used as an adhesive plaster, a surgical drape, a taping tape, etc. without containing a drug, and further contains a drug as required. You may.

As the drug, those which can penetrate a biological membrane by transdermal or transmucosal administration can be applied without particular limitation.
For example, antipyretic antiphlogistic analgesics, steroidal anti-inflammatory drugs, vasodilators, hypertension / arrhythmia drugs, antihypertensive drugs, antitussive expectorants, antitumor drugs, local anesthetics, hormonal drugs, asthma, allergic rhinitis treatment drugs, antihistamines , Anticoagulants, anticonvulsants, cerebral circulation / metabolic improvers, antidepressants / anxiolytics, vitamin preparations, oral hypoglycemic agents, antiulcer agents, sleeping pills, antibiotics,
Examples include skin irritants.

Examples of the antipyretic and antiphlogistic analgesic include salicylic acid, methyl salicylate, glycol salicylate, glycyrrhetinic acid, glycyrrhizic acid, indomethacin, ketoprofen, flurbiprofen, ampfenac and the like.

The antihistamines include diphenhydramine, diphenhydramine hydrochloride, chlorpheniramine maleate and the like.

Examples of the skin irritants include menthol, peppermint oil, camphor, vanillyl amide nonylate, benzyl nicotinate, β-butoxyethyl nicotinate, pepper (extract), capsaicin, and sanshishi (extract).

As vasodilators, isosorbide dinitrate,
Pentaerythritol tetranitrate, nifedipine and the like.

With respect to the amount of drug added, it is possible to add the drug in a proportion of up to 30% by weight based on the whole pressure-sensitive adhesive layer. The reason is that if the compounding amount of the drug exceeds 30% by weight, the function of the above-mentioned pressure-sensitive adhesive is impaired, and it becomes impossible to satisfy sufficient adhesiveness and low irritation to the skin.

C) In the pressure-sensitive adhesive layer of the pressure-sensitive adhesive tape or sheet for medical use according to the present invention, a liquid polymer component is blended if necessary. As the liquid polymer component, one that is compatible with a styrene-based thermoplastic elastomer made of an ABA block copolymer, such as polyisobutylene, polybutene, or liquid polyisoprene, is used.
From the viewpoint of sticking properties, polybutene is preferred as the liquid polymer component. The addition amount of the liquid polymer component is preferably 10% by weight or less in the rubber-based pressure-sensitive adhesive. The reason for this is that if the added amount exceeds 10% by weight, it is not possible to ensure sufficient sticking properties and sufficient low irritation to the skin.

In the pressure-sensitive adhesive layer of the pressure-sensitive adhesive tape or sheet for medical use according to the present invention, in addition to the above-mentioned drug and liquid polymer component, an antioxidant, a filler and the like are used as long as they do not impair the effects of the present invention. May be appropriately added.

D) As the material of the support used in the present invention, non-woven fabric, woven fabric, polyester, polyethylene,
Examples thereof include polyvinyl chloride, polyvinylidene chloride, ethylene-vinyl acetate copolymer, polyurethane, perforated aluminum foil, and a laminate film thereof. Among these materials, it is preferable that a material having low moisture permeability is subjected to physicochemical processing to impart moisture permeability. This treatment is to prevent rash due to excessive stuffiness of the skin. Further, the support preferably has a function of expanding and contracting in at least one direction, and a material having no such function is preferably subjected to an appropriate expansion / contraction process. This is because if the support has a stretching function, it can follow the stretching of the skin surface when the medical adhesive tape or sheet is applied to the body. The thickness of the support is preferably 5 to 2,000 μm.

E) Examples of the release paper described later used in the present invention include polyester, polypropylene, polyethylene-coated high-quality paper, polyethylene-coated glassine paper, and the like whose upper surface is subjected to silicon treatment. The thickness of the release paper is preferably 20 to 200 μm.

F) Representative examples of the method for producing the medical pressure-sensitive adhesive tape or sheet according to the present invention include a solvent method,
Hot melt method is mentioned.

In the solvent method, a water-soluble polymer and a fatty acid ester of a polyhydric alcohol are added to a rubber-based pressure-sensitive adhesive, and if necessary, a drug component and / or a liquid polymer component and other additives are added. Dissolve or disperse uniformly. Examples of the solvent used include those that are compatible with rubber-based pressure-sensitive adhesives, drugs, and the like, for example, tetrahydrofuran, chloroform, and methylene chloride. However, among the water-soluble polymers, polyvinylpyrrolidone is difficult to dissolve unless it is an alcohol-based solvent. Therefore, it is advisable to first dissolve this in methanol or the like and then mix it with other components. The solution or dispersion thus obtained is spread on release paper (or support), dried to remove the solvent, and the support (or release paper) is laminated on the obtained pressure-sensitive adhesive layer.

When the hot melt method is applied,
A predetermined amount of a rubber-based adhesive, a water-soluble polymer and a fatty acid ester of a polyhydric alcohol, a liquid polymer component, and other additives are blended in predetermined amounts, and the blend is heated at a temperature of 120 to 150 ° C. under a nitrogen atmosphere. Mix and melt. After melting,
The temperature of the pressure-sensitive adhesive is lowered to 100 to 120 [deg.], And if necessary, a drug component is added and mixed uniformly to obtain a solution in a molten state. Next, this solution is spread on a release paper (or a support) using a hot melt coater, and the support (or a release paper) is laminated on the obtained pressure-sensitive adhesive layer.

[0036]

Since the present invention is constituted as described above, it imparts moisture permeability at the time of sticking without impairing the adhesiveness of the rubber-based pressure-sensitive adhesive. It is possible to provide a low-irritant medical pressure-sensitive adhesive tape or sheet having almost no stimulus.

[0037]

EXAMPLES Examples of the present invention will be described below.

Examples 1 to 12 and Comparative Examples 1 to 10 Ingredients other than the drug were blended in the proportions shown in Tables 1 to 5, and the resulting blend was heated at a temperature of 120 to 160 ° C. under nitrogen substitution. Stir and melt. After melting, set the temperature to 100-120
C., the drug was added, and a solution was obtained by homogeneous mixing. In addition, in Example 1, since no drug was contained, the mixture was melted after the heating and stirring to obtain a solution.

Next, using a hot melt coater, the solution in a molten state is spread on a release paper made of polyethylene-coated high-quality paper so that the thickness after cooling becomes about 200 μm.
Next, a 30 μm-thick polyurethane film was laminated on the adhesive layer as a support. Thus, Examples 1 to
Twelve medical adhesive tapes were obtained.

In the same manner as above, medical adhesive tapes of Comparative Examples 1 to 10 were prepared with the formulations shown in Tables 6 to 9.

[0041]

[Table 1]

[Table 2]

[Table 3]

[Table 4]

[Table 5]

[Table 6]

[Table 7]

[Table 8]

[Table 9] The details of the components used in Tables 1 to 9 are as follows.

SIS: Styrene-isoprene-styrene block copolymer (trade name: CARIFLEX TR1107 (solution viscosity: about 1)
600 cP (25 wt% toluene solution); styrene / rubber weight ratio: 14/86 (manufactured by Shell Chemical Co., Ltd.)) Tackifying resin: alicyclic saturated hydrocarbon resin Trade name Archon P-90 (softening point 90 ° C., Arakawa Chemical) Heavy liquid paraffin (manufactured by Nikko Pharmaceutical Co., Ltd.) Polybutene Trade name Nisseki polybutene (average molecular weight: about 1350) (manufactured by Nippon Petrochemical Co., Ltd.) Water-soluble polymer polyvinyl pyrrolidone Trade name Kollidon K90 (manufactured by BASF) Polyvinyl alcohol Product name P. V. A C-17 (manufactured by Shin-Etsu Chemical Co., Ltd.) Methylcellulose Brand name Metrolose SM-15 (manufactured by Shin-Etsu Chemical Co., Ltd.) Corn starch (manufactured by Wako Pure Chemical Industries, Ltd.) Fatty acid ester of polyhydric alcohol glycerin monostearate Brand name glycerin monostearate MGS -B (Nikko Chemicals) Sorbitan monostearate Trade name Sorbitan monostearate SS-10 (Nikko Chemicals) Propylene glycol monostearate Trade name Propylene glycol monostearate PM
SIC (Nikko Chemicals) Polyoxyethylene sorbitan monostearate Trade name POE (6) Sorbitan monostearate TS
-106 (manufactured by Nikko Chemicals Co., Ltd.) Polyoxyethylene glycerin monostearate Trade name POE (5) Sorbitan monostearate TM
GS-5 (Nikko Chemicals) Polyethylene glycol monostearate Trade name POE (2) Monostearate YMS-2 (Nikko Chemicals) Water-absorbing polymer Trade name Sunwet IM-300 MPS (Sanyo Chemical) (Starch / Acrylate Graft Copolymer Cross-Linked Product) In Tables 1 to 9, SIS, heavy liquid paraffin, alicyclic saturated hydrocarbon resin, and polybutene are shown by weight% with respect to the total of these components. The contents of the water-soluble polymer, the fatty acid ester of polyhydric alcohol, the water-absorbing polymer and the drug are shown in% by weight based on the whole pressure-sensitive adhesive layer.

Performance Test The performance test was performed on the medical pressure-sensitive adhesive tapes obtained in Examples and Comparative Examples by the following method.

<Adhesion Test> An adhesion test on human skin was performed on each of the medical adhesive tapes (3 × 4 cm) of Examples and Comparative Examples as follows. That is, a medical adhesive tape was applied to the upper arms of five (healthy, male) subjects, and after 12 hours, the adhesive property and the feeling of application were evaluated. Each medical adhesive tape was evaluated for pain and irritation at the time.
The number of repetitions was one. Table 1 shows the results of this sticking test.
0 to Table 14.

[0045]

[Table 10]

[Table 11]

[Table 12]

[Table 13]

[Table 14] 1) Adherability: After adhering for 12 hours, the ratio of the area to which the medical adhesive tape was adhered to the area at the start of the test was observed.

Good: The residual adhesive area of the patch was 95% or more. Normal: The residual adhesive area of the patch was 75% to less than 95%. Poor: The residual adhesive area of the patch was less than 75%. Was.

2) Residual adhesive: After peeling, it was evaluated whether or not the adhesive remained on the skin. -: The adhesive did not remain on the skin after peeling. +: The adhesive remained on the skin after peeling.

3) Pain at peeling: Pain at peeling was evaluated by a sensory test. -: No particular pain was felt ±: Slight pain was felt +: Very pain was felt.

4) Irritation: About 1 hour after peeling, the condition of the skin at the application site was visually judged. -: No change ±: Slight erythema is observed +: Erythema is observed

5) Stickiness: The stickiness at the time of the sticking test was evaluated by a sensory test. -: No humidity ±: Slightly humid +: Slightly humid

<Moisture Permeability Test> The moisture permeability test was performed according to JIS Z
[0208] The test was carried out in accordance with "Moisture Permeability Test Method for Moistureproof Packaging Material (Cup Method)". That is, about 12 g of anhydrous calcium chloride is put in a cup, and the mouth of the cup is sealed with a medical adhesive tape. The test cup was placed in a thermo-hygrostat at 40 ° C. and a relative humidity of 90%. After standing for 24 hours, the increase in the mass of calcium chloride was measured to determine the moisture permeability (g / m ² · 24 hours).

As is clear from Tables 10 to 14, it is recognized that the medical pressure-sensitive adhesive tapes of the examples are excellent in any of the test items.

On the other hand, in Comparative Example 4, since the amount of the water-soluble polymer added was 30% by weight or more, the surface of the pressure-sensitive adhesive at the time of coating was non-uniform, the sticking property was poor, and adhesive residue was left. Was.

In Comparative Example 5, the addition amount of glycerin monostearate as a fatty acid ester of polyhydric alcohol was 3
Since the content was 0% by weight or more, glycerin monostearate bleeded from the pressure-sensitive adhesive layer, adhesion was poor, and adhesive residue remained.

In Comparative Example 7, the amount of SIS added was 25% by weight.
Was painful at the time of peeling.

In Comparative Example 8, since the added amount of SIS was less than 5% by weight, the sticking property was poor and adhesive residue was left.

Comparative Example 9 is an example of a medical pressure-sensitive adhesive tape described in Japanese Patent Publication No. 54-44688, in which glycerin bleeded from the pressure-sensitive adhesive layer, and the adhesive property was poor.

Comparative Example 10 is an example of the medical pressure-sensitive adhesive tape described in Japanese Patent Application Laid-Open No. 1-297069, and the sticking property was poor.

──────────────────────────────────────────────────続 き Continued on the front page (58) Field surveyed (Int.Cl. ⁷ , DB name) A61K 9/70 A61L 15/06

Claims (2)

(57) [Claims] 1. A medical pressure-sensitive adhesive tape or sheet in which a pressure-sensitive adhesive layer is provided on one side of a support, wherein the pressure-sensitive adhesive layer is made of a styrene-based thermoplastic elastomer composed of an ABA block copolymer. ~ 25% by weight, carbon number 10 ~
A rubber-based pressure-sensitive adhesive containing 75 to 95% by weight of a paraffinic and / or naphthene-based hydrocarbon and a tackifier resin, and a water-soluble polymer 2 to 30 compounded in the pressure-sensitive adhesive layer.
% By weight and fatty acid ester of polyhydric alcohol 2 to 30
% By weight (provided that the pressure-sensitive adhesive layer contains silicic anhydride
Not included. ), A moisture permeability of 60 g / m ² · 24 hr. Less than
Upper medical adhesive tape or sheet. 2. The weight ratio of the paraffinic hydrocarbon and / or naphthenic hydrocarbon to the tackifier resin is 2: 3.
The medical pressure-sensitive adhesive tape or sheet according to claim 1, wherein the pressure-sensitive adhesive tape or sheet is in the range of ~ 3: 2.