JP3110020B2 - Helicobacter pylori disinfectant - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to relates to a disinfectant of Helicobacter pylori as an active ingredient cocoa fraction contained in cacao mass.

[0002]

BACKGROUND OF THE INVENTION Helicobacter pylori is a gram-negative spiral bacterium isolated from the gastric mucosa of patients with chronic gastritis by Warren and Marshall of Australia in 1983, and is reported to be isolated at a higher rate than patients with gastritis and duodenal ulcer. Have been.

[0003] Infection with this bacterium is known to cause acute gastritis and chronic gastritis, and also acts as a recurrence factor and a healing delay factor for gastroduodenal ulcer. The rate (usually 70-80% recurs after one year) drops dramatically (relapse rate 0-
30%) has been reported by many researchers.

[0004] Incidentally, the infection rate of Helicobacter pylori in Japan increases with age, and is as high as about 75% in the age of 40 or older.

As described above, the eradication of Helicobacter pylori has great merit for treating peptic ulcer, but the eradication method has been changed due to the relationship between the merit and the side effect. That is the reality.

[0006] First, the triple therapy of bismuth, tetracycline and metronidazole recommended by the World Gastroenterological Association held in Sydney in 1990 has the merit of high eradication rate (90% or more eradication rate). However, the frequency of side effects was high, and many patients could not continue taking the drug. Then, in the United States in 1994, NIH (Nat
ionical Institute of Health
According to the unified opinion in h), a report was issued that helicobacter pylori-positive ulcer patients, regardless of their onset or recurrence, require antimicrobial treatment in addition to treatment with acid secretion inhibitors. According to the report, it was first reported that the combined use of a proton pump inhibitor (hereinafter, referred to as PPI), which is an acid secretion inhibitor, and one antibacterial agent was effective with few side effects. However, since the eradication rate of this method is not always high and cannot be said to be sufficient, attempts have been made to change the type of antibacterial agent in various ways.

[0007] Recently, a combination of PPI and two kinds of antibacterial agents has been reported by further adding another antibacterial agent. However, the evaluation of the efficacy and side effects thereof is at present. .

On the other hand, JP-A-11-1429 discloses an anti-Helicobacter pylori agent containing as an active ingredient at least one selected from peppermint oil, spearmint oil, various flavor components and various natural material extracts. I have. In addition, there is described an in vitro experimental result that an extract obtained by extracting ethanol from cao husk and cacao nib has a growth inhibitory effect on Helicobacter pylori.

[0009] However, Japanese Patent Application Laid-Open No. H11-1429 shows only the in vitro experimental results of extracts obtained by extracting ethanol from cao husk and cacao nib, and no effect in clinical tests has been confirmed.
In addition, in Test Example 2 of the publication, the results of an antibacterial test using humans in combination with cardamom ethanol extract and limonene, which had the highest antibacterial effects, are described.
The numerical value of 35% of the eradication rate obtained thereby can be evaluated in that there is no concern about side effects, but it is considered that the eradication rate is too low and the usefulness is low.

[0010]

As described above, at present, there is no established eradication therapy having both a 100% eradication effect and sufficient safety. Therefore, there is a demand for establishment of a eradication therapy which can avoid a complicated and multi-drug combination therapy having many side effects, obtain a high eradication effect by a method as simple as possible, and have few side effects.

An object of the present invention is to provide a safe, easy-to-use, and nutritionally-pure disinfectant for Helicobacter pylori, which has no side effects and has the above problems in the prior art.

[0012]

Means for Solving the Problems In order to achieve the above object, one of the present invention is to provide a bactericide for Helicobacter pylori, which comprises a cocoa component contained in cocoa mass as an active ingredient. Things.

[0013]

In the present invention, cocoa and / or cocoa mass are preferably employed as those containing the cocoa component.

The Helicobacter pylori eradication agent of the present invention preferably contains an antibiotic for eradication of Helicobacter pylori and / or an acid secretion inhibitor in addition to the cocoa component.

Furthermore, the Helicobacter pylori disinfectant of the present invention can be added to a food containing other nutrients and taken.
In this case, as other nutrients, those containing proteins, lipids, carbohydrates, vitamins and minerals are preferably employed.

According to the present invention, cocoa contained in cacao mass is used as an active ingredient, so that it has no side effects and is safe.
Easy and nourishing Helicobacter pylori removal
A fungicide can be provided. In addition, the use of an antibiotic and / or an acid secretion inhibitor for eradication of Helicobacter pylori not only dramatically improves the eradication rate of Helicobacter pylori, but also eliminates the eradication of pylori that could not be eliminated by conventional antibacterial agents alone. The effect is obtained that bacteria can be removed at a high rate. In addition, the cocoa component contained in cacao mass contains abundant nutritional components and physiologically active substances other than dietary fiber, so that a nutritional supplementing effect and a health maintaining effect are also provided.

[0018]

DESCRIPTION OF THE PREFERRED EMBODIMENTS In the present invention, cocoa means a component obtained by removing cocoa butter from cacao mass, and is mainly composed of protein, carbohydrate, dietary fiber (water-soluble indigestible polysaccharide, hemicellulose, cellulose, lignin, etc.). ), Phospholipids, minerals (phosphorus, magnesium, calcium, iron,
Zinc, copper, potassium, sodium, etc.), vitamin A, vitamin B group, vitamin C, vitamin E (various tocopherols, etc.), niacin, oxalic acid, citric acid, malic acid, succinic acid, lactic acid, acetic acid, tannin, Catechin, catechin, polyphenols such as quercetin), anhydrous caffeine, theobromine and the like.

As the cocoa component, for example, cocoa powder obtained by pressing cocoa butter from cocoa mass or cocoa mass itself is preferably used.

In the present invention, the antibiotic for eradication of Helicobacter pylori includes, for example, clarithromycin and the like. Examples of the acid secretion inhibitor include a proton pump inhibitor (PPI) and an H2 blocker (H2RA).

By co-administering the cocoa component and the antibiotic for helicobacter pylori eradication and / or the acid secretion inhibitor, the eradication effect can be further enhanced.

Eradication of Helicobacter pylori of the present inventionAgent
Contains the above cocoa and other nutrient sourcesFood
You can also ingest.

Examples of the other nutrient sources include, but are not limited to, proteins such as milk protein and soy protein, lipids such as vegetable oils and fats, sugars such as sugar and dextrin, vitamins, and the like.
Minerals and the like are preferably used.

In addition, the present invention eliminates Helicobacter pylori of the present invention.
The form of the food containing the fungicide is not particularly limited, for example, various foods and drinks produced using cacao mass and cocoa powder as raw materials, for example, cocoa drink, adjusted cocoa,
It can be commercialized as chocolate or the like.

In order to obtain the eradication effect of Helicobacter pylori of the present invention, it is desirable to ingest the cocoa component in an amount of 5 g or more per day in terms of cacao mass.

Therefore, in the case of ingesting the Helicobacter pylori disinfectant of the present invention as food or drink, the food or drink contains the cocoa component in an amount of 3.5 to 10% by weight in terms of solid content. Is preferred.

[0027] Even when ingesting the disinfectant of Helicobacter pylori of the present invention as a food, it is preferable to ingest a combination of Helicobacter pylori antibiotic and / or an acid secretion inhibitor, whereby eradication The effect can be further enhanced.

[0028]

The present invention will be specifically described below with reference to examples. Example 1 (Prepared Cocoa) A commercially available prepared cocoa (milk cocoa) prepared by mixing powders of raw materials such as cocoa powder, sugar, whole milk powder and skim milk powder was used as a disinfectant for Helicobacter pylori.
The components in 24 g of this prepared cocoa were as shown in Table 1, and the calorific value was 95 kcal.

[0029]

[Table 1]

Test Example 1 To a patient with no history of eradication of Helicobacter pylori and suffering from stomach and / or duodenal ulcer, the cocoa obtained in the example was administered in combination with the conventional bactericidal method. The fungal effect was examined.

Here, the conventional eradication method is a combination of a proton pump inhibitor (PPI) as an acid secretion inhibitor and clarithromycin (CAM, 400 mg / day) as an antibiotic for eradication of Helicobacter pylori. This is a method in which after administration, PPI and an H2 blocker (hereinafter, referred to as H2RA), which is also an acid secretion inhibitor, are administered in combination.

Specifically, (PPI + CAM) administration was
The administration was performed for 0 days, followed by administration of PPI for 1 month or more, followed by administration of H2RA, followed by the urease method (U), the pathological examination method (P), and the culture test method (C) to determine the eradication. Then, if at least two tests, the urease method and the culture test method, were negative, it was determined that the eradication was successful.

The cocoa was administered by adding about 120 ml of hot water to about 24 g of the commercially prepared cocoa obtained in Example 1 to make one cup, and one or more cups of cocoa per day during the sterilization period. Performed by continuing to drink. Table 2 shows the test results.
Shown in

[0034]

[Table 2]

From the results in Table 2, it can be seen that cocoa was ingested in combination, and the eradication rate of the conventional eradication method at this facility (about 4%).
0%), it was found that Helicobacter pylori could be disinfected at a higher rate (75%).

Test Example 2 To a patient who had a history of eradication by the conventional eradication method but was still unable to eradicate, cocoa was administered in addition to the conventional eradication method as in Test Example 1. The eradication effect was examined.
Table 3 shows the results.

[0037]

[Table 3]

From the results shown in Table 3, by coadministering cocoa, three out of five patients who could not be eradicated by the conventional elimination method alone were able to eradicate Helicobacter pylori. Considering the results in Table 2,
It shows that the combined use of cocoa and the conventional eradication method can significantly improve the eradication rate of the conventional eradication method.

Test Example 3 Unlike Test Examples 1 and 2, a gastric acid secretion inhibitor (PPI + H2R) was used without using an antibiotic for eradication of Helicobacter pylori.
A) and cocoa alone were administered in combination for 6 weeks or more to try to remove bacteria. Table 4 shows the results.

[0040]

[Table 4]

As shown in Table 4, one of the two cases was eradicated. This result indicates the possibility of eradication with almost no side effects.

[0042]

As described above , according to the Helicobacter pylori eradication agent of the present invention, not only can the eradication rate of the conventional eradication method be improved simply and effectively, but also the conventional eradication method can be used. The method allows eradication of patients who are difficult to eradicate.

In addition, the use of a gastric acid secretion inhibitor and cocoa alone enables the elimination of Helicobacter pylori without using an antibiotic for eradication of Helicobacter pylori, thereby reducing the number of side effects. Bacteria can be eliminated even for patients who have had difficulty in bacteria.

The cocoa content contained in cocoa mass contains abundant nutritional components and physiologically active substances in addition to dietary fiber, so that it has a nutritional supplementing effect and a health maintaining effect.

────────────────────────────────────────────────── ─── Continuing on the front page (72) Susumu Sato 2-1-1 Shimosueyoshi, Tsurumi-ku, Yokohama-shi, Kanagawa Prefecture Morinaga Confectionery Co., Ltd. (72) Inventor Shuichi Hashizume 2- Shimosueyoshi, Tsurumi-ku, Yokohama-shi, Kanagawa 1-1 Laboratory in Morinaga Seika Co., Ltd. (56) References JP-A-7-274894 (JP, A) (58) Fields investigated (Int. Cl. ⁷ , DB name) A23L 1/28-1/30 A61K 35/78 JICST File (JOIS)

Claims (3)

(57) [Claims] 1. A bactericidal agent for Helicobacter pylori, which comprises a cocoa component contained in cacao mass as an active ingredient. 2. The disinfectant for Helicobacter pylori according to claim 1, which contains cocoa and / or cocoa mass. 3. The disinfectant for Helicobacter pylori according to claim 1 or 2, comprising the cocoa component and an antibiotic and / or acid secretion inhibitor for eradication of Helicobacter pylori as active ingredients.