JP2988633B2 - Hair growth / hair restorer - Google Patents

Description

Description: TECHNICAL FIELD The present invention relates to a hair-growing / hair-growing agent characterized by containing an aqueous or alcoholic extract of aconite stalks or leaves.

(Background technology)

Conventionally, the effects of those used in the treatment of alopecia and the like are known to promote blood circulation in the scalp, activate hair cells, suppress the secretion of lipids in the scalp, and examples thereof include vitamin E,
Vitamins such as pantothenic acid, amino acids such as methionine and serine, bactericides such as salicylic acid, resorcin and hinokitiol, hormones such as ethinyl estradiol, vasodilators such as acetylcholine derivatives, skin function enhancers such as cepharanthin, etc. No. A hair restorer containing these medicinal agents is effective in preventing and improving dandruff, kayumi, hair removal and the like, and is believed to promote hair growth and hair growth.

[Disclosure of the Invention]

The present inventors have conducted various studies on hair growth and hair growth agents, and as a result, have found that water or alcohol extracts of stems or leaves of Aconitum have remarkable hair growth and hair growth promoting effects.

The present invention is based on this finding. Heretofore, it has not been known that the water or alcohol extract of the aconite stalk or leaf has a hair growth / hair growth promoting effect, and therefore, the present invention contains the water or alcohol extract of the aconite stalk or leaf. It is intended to provide a novel hair growth / hair growth promoter.

The aconite as a raw material used in the present invention is a Ranunculaceae (Ra
nunclaceae) is a plant of the genus Aconitum (Aconitum) and its main variety is Aconitum (Aconitum japonicum T.
_HUNB ., Aconitum subcuneatum N _AXAI ), Aconitum japonicum T _HUNB .var.montanum, Aconitum carmichaeli D _EBX , Ezo aconite (Aconitum yesoense N _AKAI ), and many others are known. In the area of Oriental medicine, only tuberous roots (Fushi and Ozu) are used, and stems and leaves are discarded. The foliage is slightly used for appreciation with the flower, but at present, they are discarded after the appreciation period. In the present invention, what has been conventionally treated as waste can be utilized, and also useful as an effective use of resources. As a raw material used for the hair growth and hair growth-promoting agent of the present invention, stems or leaves of aconite or any combination selected therefrom is used. As a method for producing the hair growth and hair growth-promoting agent of the present invention, the above-mentioned raw material is extracted with water or alcohol, and the extract is used. In general, aconite, not only the roots but also the stems or leaves may contain highly toxic alkaloids,
The water or alcohol extract requires special handling. From that point of view, it is preferable to use a stem or leaf which has been previously heat-treated and toxinized. This raw material is preferably minced, and water or an alcohol, for example methanol or ethanol, is added and extraction is carried out at room temperature or by heating. A mixed solvent of water and alcohol may be used as the extraction solvent. The extraction operation may be performed while stirring using a stirrer. When heating using alcohol, it is preferable to carry out by heating to reflux. The extract used in the present invention uses an appropriate base, and is used after being diluted with the base. The extract remains liquid, or concentrated to dryness, using any necessary carriers, emulsifiers, suspending agents, and fragrances commonly used in the cosmetics, pharmaceutical, and other industries,
It is formulated in a conventional manner. These materials include oleic acid, triethanolamine, beeswax, cetyl alcohol, sodium lauryl sulfate, glycerin, sodium alginate, gum arabic, sodium carboxymethylcellulose, methylcellulose,
Bentonite, vaseline, liquid paraffin, alcohols and esters thereof, for example, ethanol, propylene glycol, cetostearyl alcohol, sorbitan monostearate and the like can be used,
It can be provided in various other forms such as hair lotion and hair shampoo. It is also provided in the form of an ointment composition or a plaster composition, and these are well-known pharmaceutical carriers, for example, vaseline, paraffin, lanolin hydrolyzate, plastibase, hydrophilic vaseline, macrogol,
It may contain wax, resin, purified lanolin, rubber and the like.

Hereinafter, production examples of the extract used in the present invention will be described. In addition, the pharmacological action and safety are described in Table 1 below.
Listed in 3.

[Reference Example 1] The roots of Aconitum were ground and 1 kg of
The mixture was extracted with heating under reflux for about 1.5 hours. The extract was filtered, and the filtrate was concentrated to dryness under reduced pressure to obtain 140 g of an ethanol extract.

Example 1 Aconite stalks and leaves were pulverized, 1 kg of the extract was heated and refluxed with ethanol 10 for about 1.5 hours, the extract was filtered, and the filtrate was concentrated to dryness under reduced pressure to obtain 100 g of ethanol extract. .

[Reference Example 2] Aconite roots were treated in an autoclave at 110 ° C for 40 minutes, dried and pulverized. 1 kg of this was subjected to reflux extraction with ethanol 10 for about 1.5 hours, and the extract was filtered. Concentrate to dryness under reduced pressure to obtain 130 g of ethanol extract.

[Reference Example 3] The roots of aconite were crushed, and 1 k of the root was
Extract under heat at 1.5 ° C for 1.5 hours. The extract is filtered by centrifugation (rotation speed: 1350 rpm) with a stainless filter medium (mesh about 0.246 mm). The filtrate is concentrated to dryness to obtain 350 g of an aqueous extract.

[Example 2] The stem and leaves of aconitum are ground, and 1k of the resultant is heat-extracted with water 10 at about 100 ° C for 1.5 hours. The extract is filtered by centrifugation (rotation speed: 1350 rpm) with a stainless filter medium (mesh about 0.246 mm). The filtrate is concentrated to dryness to obtain 230 g of an aqueous extract.

[Reference Example 4] Aconite roots were treated in an autoclave at 110 ° C for 40 minutes, dried and pulverized.
Heat extraction for 1.5 hours. The extract is filtered by centrifugation (rotation speed: 1350 rpm) with a stainless filter medium (mesh about 0.246 mm). The filtrate is concentrated to dryness to obtain 330 g of an aqueous extract.

[Experimental Example 1] (Hair-growth effect) Std: ddY male mice (body weight 25 to 30 g) were used in the experiment. The animals were housed at room temperature 24-25 ° C., with free access to water, food, and 12-hour light / dark conditions. On the day before the start of the experiment, the mice were partially depilated with a depilatory cream and used. Each 1 g of the extract obtained in each of the above Examples and Reference Examples was dissolved in 20 ml of ethanol to prepare a sample solution. 0.1 ml of the sample solution was applied twice daily in the morning and evening to the hair-removed site. In the control group, 0.1 ml of ethanol was applied to the site where the hair was removed. The judgment was made by visual observation, and the criterion was based on the following criteria.

The results are shown in Table 1. As is clear from the results in Table 1, the extract used in the present invention was found to have a hair growth promoting effect.

[Experimental Example 2] (Effect of promoting hair growth) Male Std: ddY mice (body weight 25 to 30 g) were used in the experiment. The animals were housed at room temperature 24-25 ° C., with free access to water, food, and 12-hour light / dark conditions. On the day before the start of the experiment, the mice were partially depilated with a depilatory cream and used. Each 1 g of the extract obtained in each of the above Examples and Reference Examples was dissolved in 20 ml of ethanol to prepare a sample solution. 0.1 ml of the sample solution was applied twice daily in the morning and evening to the hair-removed site. As a control, 0.1 ml of ethanol was applied to the dehaired site. 7 and 1 after application
On the 4th, sampling was performed on the new hair generated from the hair loss site, and the body hair length was measured. The measurement of the body hair length was performed using a stereomicroscope. Five of the longest hairs were selected from any of the 20 sampled hairs, and the average value was determined to be the mouse hair length. The results are shown in Table 2.

[Experimental Example 3] (Safety) As a test method, a 24-hour human forearm closed batch test was used. The test subjects were 6 adult males and 2 adult females. The judgment criteria were based on the following criteria.

++: intense erythema +: erythema ±: slight erythema-: negative The results are shown in Table 3. As shown in Table 3, the extract of Aconite according to the present invention did not show any skin irritation and allergic properties, and the skin safety was extremely high. In the test subjects, no side effects other than the skin were particularly observed during the test.

Claims (1)

(57) [Claims] 1. A hair growth and hair growth-promoting agent comprising water or alcoholic extract of aconite stalk or leaf.