JP2974081B2 - Aerosol composition for human body - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION INDUSTRIAL APPLICATION The present invention relates to hair cosmetics, anti-inflammatory and analgesic external preparations, etc.
The present invention relates to an aerosol composition applied to a human body.

2. Description of the Related Art Aerosolization of hair cosmetics such as hair styling agents and external anti-inflammatory analgesics has been conventionally performed.

However, in the prior art, all of them are filled with a liquid base material and a propellant to form an aerosol, so that the spray is spread over a relatively wide range. Therefore, it is not effectively applied to a target site, and the clothes are stained. For hair cosmetics, point hairdressing cannot be performed, and in the case of an anti-inflammatory analgesic, it is necessary to increase the blending amount of the active ingredient. There was such a problem. Furthermore, since it is a liquid preparation, when applied in a large amount, it runs down and has poor retention on hair and skin, so that there are also problems in terms of usability, feeling of use, hair styling, and anti-inflammatory analgesic effects.

On the other hand, mousse-type hair cosmetics have recently been put on the market. However, this type is also basically liquid,
There are problems in terms of permeability, hair styling, and feeling of use, and since the handle is used once on the hand, the usability is not always satisfactory.

JP-A-1-294625 discloses an anti-inflammatory and analgesic external preparation using a carboxyvinyl polymer used as a gelling agent in the present invention as a stabilizer for a salicylic acid ester derivative as an active ingredient, and this external preparation. Is described as aerosolized. However, in the present invention, a carboxylvinyl polymer is used as a stabilizer to the last, and there is no technical idea to aerosolize a gel-like raw material. In fact, according to the description of the publication, it is preferable not to mix a base in order to prevent the viscosity from increasing, and all the external preparation compositions in Examples are not gelled.

Problems to be Solved by the Invention The present invention is to provide an aerosol composition for human body which has less scattering, has high adhesiveness, and has good elongation, except for the above-mentioned disadvantages of conventional aerosol products.

Constitution of the Invention The aerosol composition for human body of the present invention is characterized by containing a gel base material containing an active ingredient and a propellant, and sealing and filling the composition in a pressure-resistant container such as an aerosol can. Gives an aerosol product.

 Hereinafter, the present invention will be described in more detail.

In the present invention, it is important that the base material to be filled together with the propellant is in a gel state, and preferably has a viscosity of 2,000.
~ 100,000cp (centipoise), more preferably 3,000
Desirably, it is a high-viscosity material of up to 60,000 cp. Such a gel-like substance can be obtained, for example, by adding a gelling agent to a stock solution comprising an active ingredient and other additives such as a base to gel.

As a gelling agent, carrageenan, furceleran,
Natural polymers such as locust bean gum and xanthan gum; semi-synthetic polymers such as hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose and ethylcellulose; and synthetic polymers such as carboxyvinyl polymer are used. Carboxyvinyl polymer is a hydrophilic cross-linked polymer containing acrylic acid as a main component, and commercially available products such as Carbopol 934,940,941 of Goodrich Chemical Co., Ltd. and Hypiswako 103,104,105 of Wako Pure Chemical Industries, Ltd. can be used. . When the gel properties of the gelling agent depend on pH,
The pH is adjusted by adding an organic or inorganic base or acid.

As the propellant, an appropriate propellant conventionally used in the field of aerosol can be used. In particular, dimethyl ether has good compatibility with water and organic solvents,
Improves jetting properties by lowering the viscosity of the gel-like raw material, while volatilizing after spraying, removing heat of vaporization to give a refreshing feeling, and the raw material returns to its original viscosity on the skin and hair and is good High adhesion is obtained. Therefore, it is desirable to use dimethyl ether alone or in combination with dimethyl ether and other propellants such as liquefied natural gas, carbon dioxide gas, and fluorocarbon gas. Of course, propellants other than dimethyl ether can be used alone or in combination.

The mixing and filling ratio of the active ingredient and the propellant varies depending on their composition, type and application, but generally, the active ingredient / propellant =
A range of 90/10 to 90/90 (weight ratio) is appropriate. From the viewpoint described above, it is desirable that dimethyl ether accounts for 50% by weight or more, preferably 70% by weight or more of the propellant.

The composition of the drug substance excluding the gelling agent is appropriately selected depending on the use and purpose of the aerosol composition.

For example, when a hair cosmetic aerosol composition is used,
Hair styling agents, water, solvents such as ethanol, pigments, fragrances and the like, which are active ingredients, are added.

The type of the hairdressing agent is not particularly limited, and any of non-film-forming substances such as crosslinked polymer fine particles, fats or oils or polyoxyalkylene derivatives or phosphate esters thereof, and various film-forming substances can be used. .

Among the non-film-forming substances, the crosslinked polymer fine particles are produced by copolymerizing a monofunctional oil-soluble monomer and a polyfunctional oil-soluble monomer by a known method such as suspension polymerization, dispersion polymerization, and emulsion polymerization.

Crosslinking may be formed by copolymerizing a monofunctional oil-soluble monomer with an appropriate polyfunctional oil-soluble monomer, or after forming a homopolymer, post-crosslinking by an appropriate method, or self-crosslinking. The monomers and reaction conditions may be selected. As the polyfunctional oil-soluble monomer, those having a plurality of ethylenically unsaturated bonds are preferably used.

As a monofunctional oil-soluble monomer having only one ethylenically unsaturated bond, the glass transition temperature of the polymer is 300K
The following are preferred, for example, ethyl acrylate, propyl acrylate, n-butyl acrylate, te acrylate
rt-butyl, sec-butyl acrylate, n-acrylate
Hexyl, cyclohexyl acrylate, n-acrylate
Acrylic esters such as octyl, 2-ethylhexyl acrylate, and n-lauryl acrylate; n-methacrylate
-Butyl, n-hexyl methacrylate, n-methacrylic acid
-Methacrylates such as octyl, 2-ethylhexyl methacrylate and n-lauryl methacrylate; vinyl ethers such as methyl vinyl ether and ethyl vinyl ether; and vinyl esters.

Examples of the polyfunctional oil-soluble monomer having a plurality of ethylenically unsaturated bonds include divinylbenzene, ethylene glycol diacrylate, ethylene glycol dimethacrylate, and trimethylolpropane acrylate.

Glycerides such as castor oil, cocoa oil, mink oil, avocado oil and olive oil; beeswax,
Waxes such as whale wax, lanolin, carnauba wax; cetyl alcohol, oleyl alcohol, hexadecyl alcohol, lauryl alcohol, stearyl alcohol, isostearyl alcohol, 2-octyldodecanol,
Alcohols such as propylene glycol, polypropylene glycol, glycerin; esters such as isopropyl myristate, hexyl laurate, cetyl lactate, propylene glycol monostearate, oleyl oleate, hexadecyl 2-ethylhexanoate, octyl dodecyl myristate; dimethyl Examples include silicone derivatives such as polysiloxane, methylphenyl polysiloxane, polyether-modified silicone oil, epoxy-modified silicone oil, amino-modified silicone oil, and alkyl-modified silicone oil.

As the polyoxyalkylene derivative, for example, the following general formula (Wherein R ₁ and R ₂ are the same or different and each represent a hydrogen atom or an alkyl group having 1 to 18 carbon atoms, n is an integer of 20 to 50, m
Represents an integer of 0 to 5. ) Or a compound of the general formula (Wherein, R ₃ is an alkyl group having 4 to 18 carbon atoms, R ₄ is a hydroxyl group, A group represented by or O ^- M ⁺ , k is an integer of 20 to 40,
Represents an integer of 2 to 5, and M represents an alkanolamine or alkylamine having 2 or 3 carbon atoms, or an alkali metal such as sodium or potassium.

Film-forming substances can include film-forming polymers, preferably soluble in water and alcohol. Specifically, the following polymers (1) to (6) can be mentioned.

(1) Polyvinylpyrrolidone-based polymer compound For example, polyvinylpyrrolidone and a copolymer of vinylpyrrolidone and vinyl acetate, and vinylpyrrolidone,
Copolymers of vinyl acetate and alkylamino acrylate, and the like, and commercially available products include Rubiscol K, Rubiscol VA, Rubiflex D410I (Yuka Kadish), PVPK, PVP / VA, E-735 (GAF Company).

(2) Vinyl acetate ether-based polymer compounds Examples thereof include lower alkyl half esters of a copolymer of methyl vinyl ether and maleic anhydride, and commercially available products include Gantrez ES-225 and ES-335 (GAF
Company).

(3) Acidic polyvinyl acetate-based polymer compounds Examples thereof include copolymers of vinyl acetate and crotonic acid, and commercially available products include Resin 28-1310 and Resin 28-
There are 2930 (National Starch), Rubiset CE5055 (Yukadashi) and others.

(4) Acid acrylic polymer compound For example, acrylic acid, and / or a copolymer of methacrylic acid and alkyl acrylate and / or alkyl methacrylate, and acrylic acid, alkyl acrylate and N-alkylacrylamide And the like. As a commercial product,
Plus size (adaptive chemistry), Ultrahold 8 (Ciba-Geigy) and the like.

(5) Amphoteric acrylic polymer compound For example, dialkylaminoethyl methacrylate, dialkylaminoethyl acrylate, diacetone acrylamide and the like are copolymerized with acrylic acid, methacrylic acid, acrylic acid alkyl ester, methacrylic acid alkyl ester and the like, and halogenated acetic acid And the like, and as a commercial product, Yuka Former AM75 (Mitsubishi Yuka)
and so on.

(6) Positive acrylic polymer compound Examples thereof include diethyl sulfate of a copolymer of vinylpyrrolidone and N, N-dimethylaminoethyl methacrylic acid, and commercially available products include Guffcut 755 (GAF).

When used as an anti-inflammatory analgesic external preparation aerosol composition, various auxiliaries such as an anti-inflammatory analgesic, a solvent, an absorption enhancer, and a dissolution aid as active ingredients are added.

Examples of the anti-inflammatory analgesic include methyl salicylate, indomethacin, dichlorophenac, -menthol, dl-camphor and the like.

Examples of the solvent include water, lower alcohols such as ethyl alcohol and isopropyl alcohol, glycols such as propylene glycol, butylene glycol and polyethylene glycol, glycerin, fatty acid polyethylene glycol, crotamiton and the like.

Other auxiliaries include alcoholic esters of mono- or dicarboxylic acids having 4 to 12 carbon atoms, such as adipic acid diester and sebacic acid ester; polyoxyethylene sorbitan fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene sorbitan A nonionic surfactant such as oxyethylene alkylphenyl ether is used. Further, antibacterial agents such as sodium bisulfite, bactericides, vitamins and the like can be added.

Advantageous Effects of the Invention According to the present invention, an aerosol composition for a human body is obtained by mixing a gelled base material containing an active ingredient and a propellant, so that scattering is reduced and applied intensively to a target site. Thus, the desired effect can be efficiently exhibited without soiling clothes and the like. In addition, since it is in a gel state, it has a large adhesive force, has a good stagnation property, does not flow down, and can exert its original effect at the applied site without any problems.

The aerosol composition of the present invention is a hair cosmetic, a partial cleaning agent for the human body, an external anti-inflammatory analgesic agent, a sunscreen agent, a depilatory agent,
It can be widely applied as a composition for human body, such as a skin treatment agent and a test agent for human body.

Example 1 Vinylpyrrolidone / vinyl acetate copolymer 5.0 wt% (trade name: Rubiscol VA55E) Carboxyvinyl polymer 0.25 wt% (tradename: Carbopol) Triethanolamine 0.25 wt% Fragrance Appropriate amount Water balance 100.0 wt% An aerosol composition was prepared by adding 35 parts by weight of dimethyl ether to 65 parts by weight of the base material (viscosity of 37,000 cp), and this was filled into an aerosol can to obtain a hair cosmetic aerosol product.

The viscosity was measured at room temperature using a B-type viscometer (model BH, manufactured by Tokyo Keiki Co., Ltd.) under the conditions of a rotor No. 7 and a rotation speed of 20 rpm.

Example 2 Vinylpyrrolidone / vinyl acetate copolymer 5.0 wt% (trade name: Rubiscol VA55E) Ethanol 35.0 wt% Carboxyvinyl polymer 0.5 wt% (trade name: Carbopol) Triethanolamine 0.5 wt% Perfume Appropriate amount Water balance 100.0 wt% 30 parts by weight of dimethyl ether was added to 70 parts by weight of the base material (viscosity 47,000 cp) of the above formulation to prepare an aerosol composition, which was filled in an aerosol can to obtain a hair cosmetic aerosol product.

When the hair cosmetic aerosol products obtained in Examples 1 and 2 were actually sprayed, the gel-like hair cosmetic adhered to the hair, and unlike normal hair spray, there was little scattering, and it was effective for point hair styling. Met. Further, when the whole hair was sprayed and then spread with a brush or the like, a wet feeling peculiar to the gel and excellent hair-styling power were obtained.

Example 3-Menthol 3.0 wt% Methyl salicylate 2.5 wt% dl-Camphor 2.5 wt% dl-α-tocopherol 0.2 wt% Glycol salicylate 2.0 wt% Ethanol 39.0 wt% Carboxyvinyl polymer 0.5 wt% (trade name: Carbopol) Tri Ethanolamine 0.5wt% Water Balance 100.0wt% 25 parts by weight of dimethyl ether is added to 75 parts by weight of the base material (viscosity 30,000 cp) of the above formulation to form an aerosol composition, which is filled into an aerosol can and used for anti-inflammatory analgesic external preparation An aerosol product was obtained.

Example 4 Methyl salicylate 1.0 wt% -menthol 1.0 wt% Propylene glycol 10.0 wt% Ethanol 40.0 wt% Carboxyvinyl polymer 1.0 wt% (trade name: Carbopol) Isopropanolamine 1.0 wt% Water balance 100.0 wt% (Viscosity 5,800 cp) 28 parts by weight of dimethyl ether was added to 72 parts by weight to prepare an aerosol composition, which was filled into an aerosol can to obtain an anti-inflammatory analgesic external preparation aerosol product.

Example 5 Methyl salicylate 1.0% by weight-Menthol 1.0% by weight Glycerin 8.0% by weight Polyethylene glycol (Mw = 400) 1.0% by weight Polyoxyethylene alkyl ether 1.5% by weight (trade name: NIKKOR BO-10TX, manufactured by Nikko Chemicals) Ethanol 35.0 wt% Hydroxypropylcellulose 1.0 wt% Carboxyvinyl polymer 1.0 wt% (trade name: Carbopol) Isopropanolamine 1.0 wt% Water balance 100.0 wt% Dimethyl ether 25 based on 75 parts by weight of the above formulation (viscosity 4,100 cp) A weight part was added to obtain an aerosol composition, which was filled in an aerosol can to obtain an anti-inflammatory analgesic external preparation aerosol product.

When spraying on the affected part using each of the anti-inflammatory analgesic external preparation aerosol products obtained in Examples 3 to 5, a gel-like coating film was obtained and could be spread by hand smoothly like an ointment. In addition, compared to the fine mist of a normal spray, it does not scatter and has high adhesion, so the active ingredient is efficiently applied to the affected area, and the desired effect is exhibited with a small amount of the active ingredient, In addition, there was little adhesion to clothing and other parts other than the affected area.

──────────────────────────────────────────────────続 き Continuation of front page (56) References JP-A-1-178576 (JP, A) JP-A-63-135321 (JP, A) JP-A-50-26781 (JP, A) JP-A-62 255414 (JP, A) JP-A-60-48915 (JP, A) JP-A-6-199638 (JP, A) Kokichi Tokime “Handbook”, 6 members, Nikko Chemicals Co., Ltd. (February, 1977) (1st revised edition issued) pp. 136-137, 144-147 (58) Fields investigated (Int. Cl. ⁶ , DB name) A61K 7/06 A61K 9/12 C09K 3/30

Claims (1)

(57) [Claims] 1. An aerosol composition for a human body, comprising a gel base material containing an active ingredient and a propellant.