JP2921985B2 - Binder and products using it - Google Patents

Description

Description: TECHNICAL FIELD The present invention relates to a binder and a product using the same. More specifically, the present invention relates to a binder for sugar coating, a granule product and a tableting product, comprising a water-soluble hemicellulose derived from soybean cotyledons as an active ingredient, a sugar coating composition containing the binder, and a sugar coating. Coating composition obtained by coating the composition for coating, granules of powder prepared when producing a ramune confectionery or tablet containing the binder, and a tableting product obtained by tableting the granules About.

In the present invention, the sugar coating refers to a sweet film (roll) containing sugar applied to confectionery or tablets, and the sugar coating composition refers to a composition for sugar coating production. The sugar-coated composition refers to a composition such as a sugar-coated confection or a tablet.

Background Art Sugar-coated tablets such as sugar-coated confectionery and medicines such as marble chocolate protect sugar-coated clothing by forming a sugar film such as sugar on the surface thereof, or make it easy to eat,
Or make it easy to drink. Sugar-coating is usually carried out using a sugar such as gum arabic, processed starch, or a protein such as gelatin as a supplement, and mixing with an aqueous solution of sugar to produce a viscous, high-concentration sugar solution. It is performed by coating a sugar-coated garment and drying it by blowing air several times to form a film.

In addition, tablets such as tablet confections and pharmaceutical substances such as ramune confectionery are kneaded with various binders such as gum arabic, or granules, and then compression-molded such as tableting. It is manufactured by drying if necessary. Tablets and tablets prepared without using a binder are partially chipped or cracked by physical force applied from the inside or the outside during production or during storage after production. In addition, when using a binder to prepare powder granules before tableting, the workability afterwards is deteriorated if good granules having a uniform size cannot be prepared. Use is essential. Gum arabic used as such a binder is obtained by purifying using acacia sap.

However, in recent years, since the production amount of gum arabic has been drastically reduced due to abnormal weather and political change in Sudan, which is a major producing country, the price has been rising, and the production output and the price fluctuation have been severe. Gelatin, dextrin, and the like are binders that are stable in price, but they have weak binding power and cause cracks on the surface of the sugar coating or drop off of the sugar coating during the coating process. In addition, polysaccharides such as gum arabic and dextrin cannot produce the above-mentioned good granules.
Therefore, in these industries, inexpensive sugar coating compositions having a high coating strength and being supplied stably, and a natural, low-priced, high-binding, high-granulation granule that can be well prepared before compression. A stable amount of granules and binders for tableting products is desired.

DISCLOSURE OF THE INVENTION The present invention has a workability, a coating property and a sugar coating strength equivalent to or higher than that of an auxiliary agent such as gum arabic when sugar-coated on confectionery or tablets, and can be supplied stably and inexpensively. It is intended to provide a composition, a sugar coating composition, a granulated product, and a tableting product using the same.

The present inventors have conducted intensive studies in view of the above points, and as a result, when water-soluble hemicellulose derived from soybean cotyledons is used as a binder, a workability is good, and a sugar coating composition excellent in coatability and sugar coating strength is obtained. The powder obtained during the production of tablets and confections and tablets can be satisfactorily granulated, and there is little chipping or cracking after tableting, and the texture or disintegration when eating or taking is other than that. It has been found that this is comparable to the case where a binder is used. The present invention has been completed based on such findings.

Therefore, the present invention provides a binder for sugar coating, a granule product and a tableting product, comprising a water-soluble hemicellulose derived from soybean cotyledon as an active ingredient, a sugar coating composition using the binder, and a sugar coating composition. A sugar-coated composition obtained by sugar-coating a product; and a granulated product and a tableted product using the binder.

BEST MODE FOR CARRYING OUT THE INVENTION The water-soluble hemicellulose in the present invention is preferably derived from soybean cotyledons.

The water-soluble hemicellulose derived from soybean cotyledons can be used at any molecular weight, but preferably has an average molecular weight of tens of thousands to several millions, specifically 50,000 to 10
Preferably, it is 0,000. If the average molecular weight is less than 50,000, the binding property is poor, and if it exceeds 1,000,000, the workability at the time of tablet or confection production becomes poor, and when eaten or taken, the degree of partial disintegration is low and the texture is reduced. They tend to be impaired or have reduced medicinal effects. The average molecular weight of the water-soluble hemicellulose is a value determined by an intrinsic viscosity method for measuring the viscosity in a 0.1 M NaNO ₃ solution using standard pullulan (manufactured by Showa Denko KK) as a standard substance.

The water-soluble hemicellulose derived from soybean cotyledon in the present invention can be obtained by extracting water from a raw material containing hemicellulose and, in some cases, eluting with heating under vinegar or alkaline conditions or decomposing and eluting with an enzyme. An example of a method for producing such a water-soluble hemicellulose is as follows.

Polysaccharide residues of soybeans, usually excluding fats and oils, proteins and starch, can be used as raw materials, and tofu, soymilk, and okara by-produced when producing isolated soybean proteins can be used.

These raw materials are prepared under acid or alkaline conditions, preferably at a pH near the isoelectric point of each protein, preferably 13
Decompose by heating at 0 ° C or lower and 80 ° C or higher, more preferably 130 ° C or lower and 100 ° C or higher, fractionate the water-soluble fraction and then dry as it is, for example, activated carbon treatment, resin adsorption treatment or ethanol precipitation. Water-soluble hemicellulose can be obtained by treating to remove hydrophobic substances or low molecular substances and then drying.

When the soybean cotyledon-derived water-soluble hemicellulose thus obtained is added to a sugar-coating composition and used, the amount is 1 to 30% by weight, more preferably 2 to 20% by weight, based on the whole sugar-coating composition. It is preferable to add in an appropriate amount. It is possible to apply sugar even if the amount is outside these ranges, but if the amount is small depending on the amount of sugar, the strength of the coating film is low and the sugar coating may crack or fall off. In addition, when the amount of addition increases, the drying time tends to increase.

The method for producing granules or tablet products may be in accordance with a conventionally known method for producing granular products, tablet confections or tablets. At this time, the soybean cotyledon-derived hemicellulose according to the present invention may be used in place of the polysaccharide or gelatin such as gum arabic which is usually used as a binder for granules or tableting products. That is, a binder solution is prepared in advance using this hemicellulose. The concentration of the binder solution is generally in the range of 5 to 80%, preferably 5 to 20%. If the concentration is too high, the viscosity becomes high and the workability deteriorates. Conversely, if the concentration is too low, the binding effect will be poor and it will be difficult to obtain good granules or tableted products.

Such a binder solution is sprayed while drying the powder raw material mixture or added to the powder raw material mixture and kneaded well. The amount of the binder solution to be used is not particularly limited, but may be 0.5 to the total mixture in terms of dry matter.
It is good to use it in such an amount that it becomes 1010% by weight. When the amount is less than 0.5% by weight, the binding property of the binder is not sufficiently obtained. On the other hand, when the amount is more than 10% by weight, the granules prepared at the time of preparing the granules are not good, This is because the texture and disintegration tend to be impaired. Then, it is set on a tableting machine and tableted. After molding, drying is performed if necessary.

The water-soluble hemicellulose derived from soybean cotyledon in the present invention can be effectively used alone as an auxiliary agent for a sugar-coating composition. There is no problem when used in combination with proteins such as gelatin and gelatin.

Further, in the present invention, if necessary, another binder may be used in combination with soybean cotyledon-derived hemicellulose. Examples of other binders include general gums represented by gum arabic, starch and processed starch, and proteinaceous substances represented by gelatin.

According to the present inventors, the effect in the present invention, due to the molecular weight and structure of water-soluble hemicellulose derived from soybean cotyledons, excellent film-forming properties after drying, furthermore, the film has a certain degree of moisture retention This is considered to be based on the occurrence of suppleness.

Further, as disclosed in Japanese Patent Application Laid-Open No. 62-32844, when producing tablet confectionery, an emulsion comprising a water-soluble organic polymer compound, an emulsifier and an oil or fat is used as a binder to make the tablet smooth. When trying to obtain tablet confections having a pleasant texture, the effect of soybean cotyledon-derived hemicellulose in the present invention itself can be obtained without using an emulsifier because it has emulsifying properties.

As described above, a sugar coating composition produced using soybean cotyledon-derived hemicellulose as a binder has excellent workability, coating properties and adhesiveness, and granules and tablet products have excellent binding power, and Chips and cracks during storage are reduced.

Hereinafter, the present invention will be further described with reference to examples. However, these are examples, and the spirit and scope of the present invention are not limited by these examples. In addition,
In the following, all parts and percentages are by weight.

Preparation of water-soluble soybean hemicellulose (SSHC)
Add twice the volume of water, adjust the pH to 4.5 with hydrochloric acid, and
Hydrolyzed for 1.5 hours. After cooling, centrifuge (10000G × 3
(0 min), the mixture was separated into a supernatant and a precipitate. The precipitate thus separated was further washed with water of an equal weight, centrifuged, and the supernatant was treated with an activated carbon column together with the supernatant, followed by drying to obtain SSHC (a). In addition, drying was performed without performing the activated carbon column treatment to obtain SSHC (b).

Further, this SSHC (a) was dissolved in a 0.5% saline solution, and reprecipitation was repeated three times so that the ethanol concentration became 50%, and an ion exchange resin ("Amberlite IR-120B" manufactured by Organo Co., Ltd.) was used. The salt was used to obtain SSHC (c).

 The composition ratio of the obtained SSHC was as follows.

Next, the sugar compositions of SSHC (a), (b) and (c) were analyzed. In the analysis, uronic acid was measured by Blumenkrantz method, and neutral sugar was measured by alditol acetate method.

 The results were as follows.

Example 1 Chocolate was sugar-coated using the composition for sugar coating shown below using SSHC (a). As a comparison, sugar coating was similarly performed using commonly used gum arabic (manufactured by Kishida Chemical Co., Ltd.) and processed starch (Foodtex, manufactured by Matsutani Chemical Co., Ltd.).

Sprinkle the sugar coating composition onto the spherical chocolate charged in the rotating pot according to a conventional method, then sprinkle the powdered sugar to adhere to the surface and then blow dry. After repeating the process of sprinkling and adhering and blowing and drying four times, finally, it was shellaced to prepare a chocolate-coated chocolate confection.

The evaluation results of the obtained sugar-coated chocolate confectionery are shown below.

From the above results, it can be seen that the sugar-coating composition using SSHC shows better results with a small amount of use than commercially available gum arabic.

Example 2 Simulated naked tablet consisting of lactose and starch having a diameter of 7 mm and a weight of 120 mg
Using 20000 tablets, a sugar coating composition solution was prepared according to the formulation shown below, and a sugar coating test was carried out using a rotating pot for sugar coating with pullulan, gum arabic and gelatin as controls. Then, the sugar-coated strength of the sugar-coated tablet was evaluated by a drop test.

Sugar coating was carried out as follows.

First, with respect to the underlayer, an operation of applying the underlayer solution at the respective times and amounts shown below, then spraying talc and drying was repeated 13 times.

Next, with respect to the smoothing layer, the operation of applying the solution for the smoothing layer at the respective times and amounts shown below and then drying was repeated 20 times.

Next, the operation of applying the solution for the overlying layer at the respective times and amounts described below and then drying was repeated 15 times for the overlying layer.

Drop test method 500 sugar-coated tablets prepared as described above were put into a plastic container, dropped on concrete from a height of 1 m, and the number of broken tablets was examined.

From the above results, it can be seen that sugar-coated tablets coated with the sugar-coating composition of the present invention have excellent sugar-coating strength and good gloss on the sugar-coated surface. There was no problem with the breaking speed.

The operations of the above examples were performed using SSHC (b) and (c), and the results were almost the same.

Example 3 and Comparative Example 7 A ramune confectionery was prepared using SSHC (a), and those using gum arabic (control) and those not using (comparative example 7) for comparison as shown below. Then, the appearance at the time of tableting, the appearance at the time of the drop test, and the disintegration property were observed.
Compression of ramune confectionery at 23 kg / cm ² with a ramune molding machine
This was performed by forming a single column having a diameter of 8 mm and a thickness of 6 mm, followed by drying at 80 ° C. for 60 minutes. In the drop test, 100 grains were packed in a polyethylene bottle, dropped freely from a height of 100 cm, and the state of cracking was observed. Regarding the disintegration property, the disintegration rate was measured using a disintegration degree tester in a warm water at 37 ° C. (average of 10 pieces).

The evaluation results were as follows.

As can be seen from the above evaluation results, when SSHC (a) was used as a binder, the appearance at the time of stamping and the degree of disintegration were not inferior to the control using gum arabic as a binder. The test results were excellent. Further, as compared with Comparative Example 1 in which no binder was used, the tableting state, drop test, and disintegration were all excellent.

Example 4 Next, a 10% by weight aqueous solution of SSHC (a) was prepared, and this aqueous solution was sprayed on powdered sugar to prepare powdered sugar granules. The powdered flavor was added to the granules, 16mm diameter at a pressure of 200 kg / cm ²
Was tableted and dried to produce tablet confections. For comparison, the same operation was performed using a 10% by weight aqueous solution of gum arabic (control), and the same operation was performed using only water (Comparative Example 8).

The state of the prepared granules, the state at the time of tableting, the state at the time of the drop test, and the disintegration were observed in the same manner as in the previous example.

 The composition and evaluation results are shown below.

As can be seen from the above results, in the case of the tablet confections produced by the above-mentioned method, as in Example 3, there was no problem in workability such as cracking during tableting, and the strength of the tablet confections was also Arabic. It was as strong as the control when gum was used. From these results, it is presumed that the same effect as in Example 4 can be obtained even if SSHC (a) is used for a tablet or the like obtained by tableting with a similar formulation as in Example 4. . Especially,
The powder granules prepared before tableting had better size uniformity and flowability than the granules prepared using gum arabic. From this, it is considered that granulation using this SSHC (a) can be widely applied to granulation of powder.

Example 5 A 10% by weight aqueous solution of SSHC (a) and an aqueous solution of gum arabic for comparison were prepared. 95 parts of this aqueous solution was heated, and 5 parts of vegetable oil / fat having a melting point of 38 ° C. was added thereto to emulsify. This emulsion was sprayed on powdered sugar to prepare powdered sugar granules. A powder flavor was added to the granules, and the granules were tableted at a pressure of 200 kg / cm ^{2 into} tablets having a diameter of 16 mm to produce tablet confections.

 The composition and evaluation results were as follows.

As can be seen from the above results, in the case of the tablet confections produced by the above-mentioned method, as in Example 3, there was no problem in workability such as cracking during tableting, and the strength of the tablet confections was also Arabic. The strength was the same as when using gum. In addition, as a result of the sensory evaluation, when using SSHC (a), as in the case of gum arabic, the tongue was good and a smooth tablet was obtained. From this, it was confirmed that the use of the emulsion prepared using SSHC (a) had the same effect as the control using gum arabic.

In each of the examples, when the SSHC (a) was changed to the SSHC (b) and the SSHC (c), the results were almost the same as the results when the SSHC (a) was used.

Industrial Applicability The water-soluble hemicellulose derived from soybean cotyledons according to the present invention can be produced relatively easily and inexpensively, and beans are stable because they are high-yield agricultural products worldwide. The product can be supplied, and when such a water-soluble hemicellulose derived from soybean cotyledon is used for a sugar-coating composition, a product having excellent adhesiveness and coatability can be obtained. This effect is comparable to gum arabic, which shows the best effect as a sugar coating composition. In addition, by using it as a binder for granules and tablet products, granules with uniform size and shape and excellent fluidity can be obtained, and tablet products with excellent quality such as binding properties can be obtained. can get.

──────────────────────────────────────────────────続 き Continuation of the front page (56) References JP-A-4-197138 (JP, A) JP-A-62-32844 (JP, A) JP-A-5-7449 (JP, A) JP-A 57- JP-A-61-231950 (JP, A) JP-A-3-502407 (JP, A) JP-A-2-501799 (JP, A) European publication 272119 (EP, A1) European publication 301440 (EP, A2) (58) Fields investigated (Int. Cl. ⁶ , DB name) A23G 3/00-3/32 A23G 1/00-1/28 A23L 1/20 C09J 101/00-101/32 EPAT (QUESTEL) WPI (DIALOG)

Claims (5)

(57) [Claims] 1. A binder for sugar coating, granule products and tableting products, comprising a water-soluble hemicellulose derived from soybean cotyledons as an active ingredient. 2. A sugar coating composition comprising the binder according to claim 1. 3. A sugar-coated composition obtained by coating the sugar-coating composition according to claim 2 with sugar-coated. 4. A granular product comprising the binder according to claim 1. 5. A tableting product comprising the binder according to claim 1.