JP2899268B2 - Cosmetic composition for hair - Google Patents

Description

Description: BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmetic composition for hair, characterized by containing a two-electron reducing oxidase having oxygen as an acceptor as an active ingredient. . A first object of the present invention is to provide a hair cosmetic composition having a sufficient effect with a mild oxidizing action. [0002] A second object of the present invention is to provide an oxidative hair dye which causes less skin irritation and less damage to hair and skin.
An object of the present invention is to provide a hair cosmetic composition having an oxidative function such as an oxidative fixative composition for a two-bath type permanent wave. [0003] Conventionally, in the case of oxidative hair dyes, hydrogen peroxide, as an oxidizing agent, has been used for oxidative polymerization of oxidative dyes and for decolorization of hair.
Sodium perborate, sodium percarbonate and the like are used. Also, in general, permanent wave treatment is
The first agent mainly containing a reducing agent such as thioglycolic acid or cysteine reduces and cuts the S—S bond in the hair, and then oxidizes the hair with an oxidizing agent such as sodium bromate, perborate or hydrogen peroxide. And a method of oxidatively fixing with a second agent containing as a main component. [0004] However, there is a drawback that these oxidizing agents may cause damage to hair and skin. According to the present invention, oxygen in the air is activated by oxidase, and the oxidizing power is effectively used in a necessary oxidation process of a product. [0006] The present invention provides a hair cosmetic composition containing at least one two-electron reducing oxidase having oxygen as an acceptor. The enzyme used in the present invention is a two-electron reduction oxidase that generates hydrogen peroxide using oxygen as an acceptor, and is pyranose oxidase (hereinafter PR).
OD), glucose oxidase (hereinafter GO)
D), glycerol oxidase, lactate oxidase, pyruvate oxidase, and uricase. [0007] In the present invention, one or a combination of two or more of these enzymes can be used. In some cases, a coenzyme is required in order for the enzyme of the present invention to work. For example, PROD contains flavin adenine dinucleotide (hereinafter abbreviated as FAD) and iron ion as coenzymes, and pyruvate oxidase contains FA.
D is known. [0008] Since these coenzymes are usually contaminated in enzymes, in the present specification, when the term “enzyme” or “oxidase” is used, it is assumed that the coenzyme contains a necessary coenzyme unless otherwise specified. . The present invention further provides a hair cosmetic composition comprising the oxidase and a donor of the enzyme. The donor is a donor of the selected enzyme, which is different from the precursor of the oxidation dye for hair coloring. For example, PROD includes D-glucose, L-
Sorbose, D-xylose, GOD, D-glucose, glycerol oxidase, glycerol, dihydroxyacetone, lactate oxidase,
Lactic acid and its salts, pyruvate oxidase,
Pyruvic acid and its salts are used, and uricase is uric acid and its salts. The amount of the enzyme to be used is 1 unit / 100 g to 1 × 10 ⁸ units / 100 g, preferably in the concentration used for actual hair.
It is 1 × 10 ² units / 100 g to 1 × 10 ⁵ units / 100 g.
The amount of the donor is 0.01% by weight based on the actual hair concentration.
６０60% by weight, preferably 1% to 35% by weight. In the present invention, when D-glucose is used as the donor, PROD is preferable as the enzyme. This is because PROD acts on both the α and β forms of D-glucose. There is an enzyme immobilization method that maintains the activity of the enzyme as high as possible to produce a stable enzyme. In the present invention, use of an immobilized enzyme is also included. In order to solubilize the enzyme in an organic solvent and also to exhibit the activity in an organic solvent, a synthetic high component or a natural polymer can be chemically bonded to the surface of the enzyme protein molecule. This modified enzyme is also included in the enzyme of the present invention. As the dye used for the oxidation hair dye, all ordinary oxidation dyes are used. In addition to resorcinol, for example, the standard for raw materials for hair dyes (revised 3rd edition, May 1985, Japan Hair Color Industry Association / Hair Dye Society) includes 5-aminoorthocresol and 3,3'-iminodiphenol. , 2,4-diaminophenol hydrochloride, toluene-2,5-hydrochloride
Diamine, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, orthoaminophenol, catechol, N-acetic acid
Phenylparaphenylenediamine, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, diphenylamine, toluene-2,5-diamine, toluene-3,
4-diamine, α-naphthol, paraaminophenylsulfamic acid, paraaminophenol, paraphenylenediamine, paramethylaminophenol, hydroquinone, pyrogallol, N-phenylparaphenylenediamine, phloroglucin, metaaminophenol, metaphenylenediamine, 5-amino sulfate Orthocresol, orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, toluene-2,5-diamine sulfate, paraaminophenol sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, meta sulfate Aminophenols and metaphenylenediamine sulfate are described. Further, 2,4-diaminophenoxyethanol hydrochloride, 5- (2-hydroxyethylamino)
-2-Methylphenol was also added. Further, 2-amino-4-, which is often used in combination with an oxidation dye, is usually used.
Nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, nitroparaphenylenediamine hydrochloride, 1,4-diaminoanthraquinone, nitroparaphenylenediamine, paranitroorthophenylenediamine, picramic acid, piclamin Sodium acid, picric acid, 2-amino-5-sulfate
Direct dyes such as nitrophenol, nitroparaphenylenediamine sulfate, paranitroorthophenylenediamine sulfate, and paranitrometaphenylenediamine sulfate are also broadly included in the oxidation dyes. Usually, in the case of an oxidative hair dye, 1.5% to 4.0% by weight of hydrogen peroxide is used in a concentration at the time of use for oxidative polymerization of an oxidative dye and for decolorizing hair. At this concentration, some hair damage is unavoidable and may cause skin damage in some people. In the present invention,
Since oxygen in the air is activated and used, hair damage and skin damage are less likely to occur than before, and the same dyeing and decoloring effects as before can be obtained. On the other hand, in the past, there are a few techniques using enzymes in hair dyeing techniques for oxidized hair dyes. For example,
JP 47-10400 proposes a hair dyeing method comprising a peroxidase enzyme, hydrogen peroxide and an oxidation dye. JP-B-51-47778 discloses dithiothreitol or / and / or dithioerythritol as a first agent.
The agent includes tyrosine or / and DL-β (3,4-
Dihydroxyphenyl) alanine or a derivative thereof,
One or more compounds selected from the group consisting of 5-hydroxyindole, methyl 5,6-dihydroxyindole-2-carboxylate, tyramine, dopamine, 6-hydroxydopamine and pyrocatechol, and a persulfate as a third agent It has been proposed to mix tyrosinase with the second or third agent. Further, Japanese Patent Publication No. 58-31325 proposes a hair dye comprising four solutions of pyrocatechol, a water-soluble salt of zinc, copper or iron, peroxidase and hydrogen peroxide. All of these use only the oxidizing action of hydrogen peroxide or persulfate, which was initially blended, and the enzymes to be blended are different.
8. In JP-B-58-31325, a precursor of a dye is specified, and the intended point is different from the present invention. The present invention also provides a two-electron reducing oxidase having oxygen as an acceptor and an oxidative fixative composition for permanent waves, which comprises a donor of the enzyme, a so-called second agent. Conventionally, the first agent is a reducing agent containing thioglycolic acid and / or cysteine, and the second agent is an aqueous solution of an oxidizing agent such as sodium bromate, potassium bromate, sodium perborate or hydrogen peroxide. is there. Usually, the concentration of hydrogen peroxide is 1.0% by weight to 2.0% by weight.
Used at 5% by weight. At this concentration, some hair damage is unavoidable and may cause skin damage in some people. In the present invention, the use of oxygen in the air reduces the risk of hair damage and skin damage compared to the past,
In addition, it can have the same oxidative fixation action as the conventional one. Next, test examples are shown. In addition,% is% by weight, the unit of the enzyme amount is PROD for D-glucose unit, and uricase is
Uric acid unit, peroxidase hydrogen peroxide unit,
Mutarotase used an α-D-glucose unit. Test Example 1 As shown in Table 1, three types of oxidases, glucose oxidase (GOD), PROD and uricase, were used as oxidizing solutions, and they were used in combination with mutarotase and / or peroxidase. A purified water only containing no agent was prepared. For these, the hair dyeing effect and the hair finish were compared and judged by the following methods and are also shown in Table 1. [Test Method] 1: 1 dye solution and oxidizing solution
Immediately weigh 2 g, length 1
It is applied to a 0 cm goat wool bundle, treated for 30 minutes, washed with water, shampooed and dried. The evaluation of the hair dyeing effect and the finish of the hair was based on the following criteria. A: Evaluation of Hair Dyeing Effect Dyeing Ability: It was dyed deep dark brown.染 It has become dark brown. Δ: Light dark brown. × Almost no staining. B: Hair finish (compared to untreated hair)。 Supple and combable. △ Somewhat supple, combing is poor. × Not supple, and poor combing. [Table 1] From the above results, those using hydrogen peroxide as an oxidizing agent are excellent in hair dyeing properties, but inferior in hair finish. And with purified water alone,
Almost no stain. In the present invention, by using oxidase as an oxidizing agent, it was possible to maintain an unprecedented excellent hair finish while having a hair dyeing effect comparable to that of hydrogen peroxide. Test Example 2 After treating the permanent wave agent with the first agent (reducing agent),
Using a composition containing uricase as the second agent (oxidative fixative), a composition containing sodium bromate as a comparison and purified water only, skin roughness by wave index, wave retention and finger dropping method The following three methods were compared and determined by the following methods, and are also shown in Table 2. [Table 2] [Wave Index and Wave Retention Measurement Test] (I) Twenty hairs below were bundled in a bundle, zigzag wound around a plastic measuring comb and fixed, and the Kilby method (Proceedings of the Science) Tiffic
According to Section 26, page 12, 1956, immersed in a first agent (reducing agent) having the composition shown in Table 2 at 30 ° C. for 10 minutes, thoroughly rinsed with water, and then each second agent (oxidative fixation) ) At 30 ° C for 10 minutes. After rinsing with water, the comb was removed from the comb and the wave degree was measured. Hair: 15 cm long human hair (10 years old, female, untreated hair) washed with a 10% aqueous solution of sodium uraryl sulfate and air-dried. (II) The hair used in (I) is immersed in a 10% aqueous solution of sodium uraryl sulfate at 60 ° C. for 20 minutes, washed with water and abused. The wave index was compared with the wave index before abuse, and this was defined as wave retention. [Test by inter-finger drop method] Inspection was made at three places between the right and left fingers of the panel (between the second and third fingers; between the third and fourth fingers; between the fourth and fifth fingers). After confirming that there is no abnormality on the skin, a 0.7 ml /
The second agent (oxidative fixing agent) having the composition shown in Table 2 was added dropwise at a rate of 10 minutes and left for 5 minutes.
Wash for 5 seconds and dry the towel twice a day.
The test is performed for three days before and after each three days after a rest for a total of six days, and the degree of roughness of the skin is observed in comparison with hands that are not tested. The experimental panel was composed of 20 girls aged 22 to 52 years
Went by name. The evaluation of the degree of skin roughness was based on the following criteria. A: Evaluation of rough skin〇 No rough skin was observed. △ Fine wrinkles are observed. × Wrinkles, dry skin and bulkiness are recognized. From the above results, it is clear that the present invention has no change in the wave effect as compared with the conventional product containing sodium bromate, and that the purified water alone has almost no wave effect. In addition, in the case of the sodium bromate-containing product, skin roughness is observed, but it is recognized that when the oxidative fixative of the present invention is used, skin roughness of the panel is significantly prevented. The cosmetic of the present invention can be used in various forms.
All the necessary drugs can be used together as one drug, but it can be conveniently used at the time of use, particularly by preparing a kit form consisting of a few drugs. A kit comprising a drug containing oxidase and peroxidase and a drug containing a donor of oxidase, a kit consisting of three drugs to which a drug containing an oxidation dye is added, or a drug obtained by mixing any one of the three drugs with the other two drugs And the like can be prepared. The hair cosmetic used for permanent waving includes a kit comprising three agents: a drug containing a reducing agent for permanent waving, a drug containing oxidase and peroxidase, and a drug containing a donor of oxidase, or an oxidase and its donor and peroxidase A kit consisting of two drugs, a drug containing a reducing agent and a drug containing a reducing agent for permanent waves, can be conveniently used. These embodiments are illustrated in the examples. Next, the present invention will be described in more detail with reference to examples. EXAMPLES Example 1 One-component hair dye (cream) paraphenylenediamine 1.35% orthoaminophenol 0.1 resorcin 0.25 cetanol 6.0 oleyl alcohol 5.0 polyoxyethylene cetyl ether (15E.O.) 7.0 liquid paraffin 10.0 Stearyltrimethylammonium chloride 1.0 Propylene glycol 2.0 Uricase (2.8 units / mg) 1.0 Uric acid 5.3 Disodium edetate 0.2 Thioglycolic acid 0.1 Monoethanolamine, Purified water Balance (pH adjusted to 8.5 with monoethanolamine) And treated at 30 ° C. for 30 minutes, washed with water, shampooed and dried. The gray hair was dyed gray. Example 2 Single-Drug Hair Dye (Gel) Paraphenylenediamine 0.08% Orthoaminophenol 0.04 Nitroparaphenylenediamine 0.4 2-Amino-4-nitrophenol 0.4 Resorcin 0.1 Sodium carboxymethylcellulose 7.5 Uricase (2.8 units / mg) 1.07 Potassium urate 2.44 Thioglycolic acid 0.1 Purified water Balance This composition is applied to gray hair, treated at 30 ° C. for 30 minutes, washed with water, shampooed and dried. The gray hair was dyed reddish-brown. Example 3 Single-Drug Hair Dye (Hair Cream Type) Paraphenylenediamine 0.135% Orthoaminophenol 0.01 Resorcinol 0.025 Cetanol 6.0 Oleyl Alcohol 5.0 Polyoxyethylene Cetyl Ether (15E.O.) 7.0 Polyoxyethylene Cetyl Ether ( 10E.O.) 3.5 Liquid paraffin 10.0 Stearyltrimethylammonium chloride 1.0 Liquid lanolin 1.0 Uricase (2.8 units / mg) 1.0 Uric acid 1.1 Disodium edetate 0.2 Ascorbic acid 0.2 Potassium hydroxide, purified water Balance (pH 7.5 with potassium hydroxide) After using this composition on gray hair for 10 to 30 minutes, the hair is immediately washed or shampooed and dried. When used on gray hair daily for 10 days, it turned gray. Example 4 One-component hair dye (treatment type) paraphenylenediamine 0.04% orthoaminophenol 0.02 nitroparaphenylenediamine 0.20 2-amino-4-nitrophenol 0.20 resorcin 0.05 cetyltrimethylammonium chloride 2.5 stearyltrimethylammonium chloride 1.0 Isopropyl myristate 7.0 Cetanol 5.0 Stearyl alcohol 2.0 Liquid paraffin 4.0 Liquid lanolin 0.5 Propylene glycol 0.5 Uricase (2.8 units / mg) 1.0 Uric acid 5.1 Peroxidase (112 units / mg) 0.003 Thioglycolic acid 0.1 Potassium hydroxide, Purified water Balance (pH This composition was adjusted to 7.5 with potassium hydroxide. The composition was applied to gray hair, treated at 30 ° C. for 30 minutes, washed with water, shampooed and dried. The gray hair was dyed reddish-brown. In addition, it is applied to hair that has been shampooed in advance in the same manner as conventional hair treatment and
Treated for 10 minutes and washed with water. When used on white hair for 10 days, it turned reddish brown in color. Example 5 One-component hair dye (powder) paraphenylenediamine sulfate 10.0% orthoaminophenol sulfate 3.0 paramethylaminophenol sulfate 2.0 sodium carboxymethylcellulose 24.0 sodium carbonate 7.36 uric acid 14.17 uricase (2.8 units / mg) 8.30 dextrin Balance First, 6 g of the above composition is made up to 50 ml with purified water to prepare a dyeing liquor.
The dye solution is applied to white hair, treated at 30 ° C. for 30 minutes, washed with water, shampooed and dried. The gray hair was dyed a dark reddish brown color. When no moisture was contained in the raw material in this powder type hair dye, the stability was improved. Example 6 Aerosol hair dye [stock solution] paraphenylenediamine 0.4% paraaminophenol 0.1 orthoaminophenol 0.5 resorcin 0.8 PROD (1 unit / mg) 10.0 D-glucose 5.5 propylene glycol 2.0 thioglycolic acid 0.1 0.1 M phosphorus First, the above composition was placed in a piston can (double container system, No. 1).
), And carbon dioxide gas is injected from the gas filling plug so that the initial volume is about 1/3 of the container and the initial pressure is about 8 to 9 kg / cm ² to obtain an aerosol hair dye. As the propellant, in addition to carbon dioxide gas, compressed gas, nitrogen and laughing gas are used.
1, 12, 114 and LPG can be used alone or as a mixture. This hair dye is applied to gray hair, treated at 30 ° C. for 30 minutes, washed with water, shampooed and dried. The gray hair was dyed gray. During storage, the aerosol-type hair dye does not come into contact with air and / or propellant, so that the stability of PROD is enhanced. In addition, instead of the piston can, the container is directly pressurized with the pressure of a bag-in can and rubber, and the contents are extruded. EXXELSYSTEM (CONTAINER
INDUSTRIES INC. USA) can be used. Example 7 Two-part hair dye (shampoo type) Note: GOD and mutarotase in the formulation are added immediately before the hair dyeing treatment. This composition is applied to gray hair, treated at 30 ° C. for 30 minutes, washed with water and dried. The gray hair was slightly purpledish brown. In addition, as in the case of the conventional shampoo, this composition is used on gray hair at 30 ° C. for 3 to 5 minutes, and then immediately washed with water and dried. When used daily on white hair for 10 days, it turned slightly purple-brown. Example 8 Two-part hair dye [dye solution] Paraphenylenediamine 2.7% orthoaminophenol 0.2 resorcin 0.5 sodium lauryl sulfate 1.0 D-glucose 11.0 disodium edetate 0.1 ascorbic acid 0.4 ammonia water, purified water balance (pH [Adjusted to 7.0 with ammonia water] [Enzyme solution] PROD (1 unit / mg) 20.0% peroxidase (112 unit / mg) 0.006 Glycerin 3.0 0.1 M phosphate buffer (pH 6.5) Balance dye first A solution obtained by mixing the solution and the enzyme solution at a ratio of 1: 1 is applied to white hair, treated at 30 ° C. for 30 minutes, washed with water, shampooed and dried. The gray hair was dyed gray. Example 9 Two-part hair dye [dye solution] paraphenylenediamine 0.8% paraaminophenol 0.2 orthoaminophenol 1.0 resorcin 1.6 oleic acid 20.0 bis-2-hydroxyethylsorbitanamine 9.0 hydroxyethyl stearylamide 6.0 propylene glycol 12.0 isopropanol 10.0 Disodium edetate 0.3 Sodium sulfite 0.3 Ammonia water, purified water Balance (pH adjusted to 8.5 with ammonia water) [Enzyme powder] Uricase (2.8 units / mg) 15.4% Uric acid 84.6 First, dye solution, enzyme powder Is applied to gray hair, treated at 30 ° C. for 30 minutes, washed with water, shampooed and dried. The gray hair was grayish brown. Example 10 Three-part hair dye [Substrate solution] D-glucose 21.6% purified water balance [enzyme solution] mutarotase (0.95 units / mg) 0.4% GOD (2.4 units / mg) 16.6 peroxidase (112 units / mg) 0.0116 glycerin 3.0 0.1M phosphorus First, a solution prepared by mixing a dye solution, a substrate solution, and an enzyme solution at a ratio of 2: 1: 1 is applied to gray hair, treated at 30 ° C. for 30 minutes, washed with water, and shampooed. dry. The gray hair was slightly purpledish brown. Example 11 Cold two-bath permanent wave agent mainly containing thioglycolic acid (thioglycolic acid-based permanent wave agent) [First agent (reducing agent)] Ammonium thioglycolate solution 13.0% (thio Polyoxyethylene oleyl ether (10E.O.) 1.0 Polyoxyethylene oleyl ether (20E.O.) 1.0 Sodium lauryl sulfate 0.5 Hydrolyzed collagen solution (20%) 2.0 Disodium edetate 0.1 Ammonia water Purified water balance (pH adjusted to 9.1 with ammonia water) [Second agent (oxidative fixative)] PROD (1 unit / mg) 20.0% Peroxidase (112 units / mg) 0.0058 D-glucose 3.6 Glycerin 3.0 Purified water Balance Note: PROD in the formulation is added immediately before the treatment with the second agent. First, according to a conventional method, the hair tips are protected with paper, wound around a plastic rod having a diameter of 1.5 cm, immersed in the first agent having the above composition at 30 ° C. for 10 minutes, and then washed with running water for 1 minute, Next, it was immersed in the second agent at 30 ° C. for 10 minutes, washed with water, and subjected to a permanent wave treatment. As a result, the hair had a good feeling that a uniform wave was obtained from the root to the hair tip. Example 12 Cold two-bath permanent waving agent containing cysteine as a main component (cysteine permanent waving agent) [First agent (reducing agent)] L-cysteine hydrochloride 7.0% cetanol 0.5 oleyl alcohol 0.5 polyoxyethylene Cetyl ether (10E.O.) 1.0 Polyoxyethylene cetyl ether (15E.O.) 1.0 Disodium edetate 0.1 Monoethanolamine, purified water balance (pH adjusted to 9.1 with monoethanolamine) GOD (2.4 units / mg) 8.3% Mutarotase (0.95 units / mg) 0.2 Peroxidase (112 units / mg) 0.0058 D-Glucose 3.6 Sorbitol 3.0 Purified water Balance Note: GOD in the formulation is It is added immediately before the two-agent treatment. The above composition was subjected to a permanent wave treatment in the same manner as in Example-11. As a result, the hair obtained a uniform wave from the root to the tip of the hair, and had a good feel. Example 13 Warming Two-bath Permanent Wave Agent Mainly Containing Thioglycolic Acid [First Agent (Reducing Agent)] Ammonium Thioglycolate 10.0% (50% as Thioglycolic Acid) Cetanol 0.5 Oleyl Alcohol 0.5 Polyoxyethylene cetyl ether (10E.O.) 1.0 Polyoxyethylene cetyl ether (15E.O.) 1.0 Disodium edetate 0.1 Ammonium hydrogen carbonate, Purified water Balance (pH adjusted to 7.5 with ammonium hydrogen carbonate) [ [Second Agent (Oxidizing Fixative)] The same composition as the two agents in Example 11 was subjected to a permanent wave treatment in the same manner as in Example 10. However, both the first and second treatments were performed at 45 ° C. As a result, the hair obtained a uniform wave from the root to the tip of the hair, and had a good feel. According to the present invention, a cosmetic composition for hair having a sufficient effect with a mild oxidizing action and an oxidizing agent for oxidized hair dye which cause less skin irritation and less damage to hair and skin And a cosmetic composition for hair having an oxidative function, such as an oxidative fixative composition for a two-bath type permanent wave.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a sectional view of a piston can used in an embodiment of the present invention.

──────────────────────────────────────────────────続 き Continued on front page (58) Field surveyed (Int.Cl. ⁶ , DB name) A61K 7/09

Claims (1)

(57) [Claims] A permanent wave cosmetic comprising a two-electron reducing oxidase having oxygen as an acceptor and a donor of the enzyme different from the oxidation dye precursor for hair dyeing. 2. The permanent wave cosmetic according to claim 1, wherein the oxidase is at least one selected from pyranose oxidase, glucose oxidase, glycerol oxidase, lactate oxidase, pyruvate oxidase, and uricase. 3. The oxidase comprises glucose oxidase,
2. The permanent wave cosmetic according to claim 1, further comprising mutarotase. 4. 4. The permanent wave cosmetic according to claim 1, 2 or 3, wherein the permanent wave cosmetic further comprises a peroxidase. 5. 5. The permanent wave cosmetic further comprises a permanent wave reducing agent.
The cosmetic for permanent wave as described in the above. 6. A form of a kit comprising a permanent-wave oxidative fixative containing a donor of the enzyme which is different from a two-electron reducing oxidase having oxygen as an acceptor and an oxidative dye precursor for hair dye, and a drug containing a permanent-wave reducing agent The permanent wave cosmetic according to claim 1, wherein 7. The permanent wave cosmetic according to claim 6, wherein the oxidase is at least one selected from pyranose oxidase, glucose oxidase, glycerol oxidase, lactate oxidase, pyruvate oxidase, and uricase. 8. The permanent wave cosmetic according to claim 7, wherein the permanent wave oxidative fixative further comprises peroxidase. 9. The oxidase comprises glucose oxidase,
7. The permanent wave cosmetic according to claim 6, further comprising mutarotase.