JP2615313B2 - Automatic analyzer - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an automatic analyzer for analyzing blood, urine, etc. of living organisms, and more particularly to an automatic analyzer having a structure for preventing infectious aerosol generated from a test object from scattering around. It relates to an analyzer.

[0002]

2. Description of the Related Art In recent years, interest in biohazard (biohazards) has been increasing in relation to biotechnology and medical testing equipment, and measures to prevent infection have been required. In an automatic analyzer such as a device for analyzing human blood or the like, a liquid sample in a sample container is injected by a probe, and the injected sample is discharged into a reaction container. When the sample is discharged into the reaction vessel, the sample becomes mist and scatters around. Then, the scattered sample may cause a secondary infection of an operator or the like or a contamination of peripheral devices or the like.

[0003] As an automatic analyzer having a gas suction mechanism for suppressing the scattering of the sample, Japanese Patent Laid-Open Publication No. 2-3116 is disclosed.
There is one disclosed in Japanese Patent Application Laid-Open No. 5-205. In the automatic analyzer described in this publication, one duct is arranged near the liquid sample dispensing mechanism. Then, the gas in the vicinity of the dispensing mechanism is sucked into the duct by the suction pump and discharged to the outside via the filter. In this case, the mist sample in the gas is removed by the filter, and the gas not containing the sample is discharged to the outside. Further, in the automatic analyzer described in the above publication, the inside of the scanning range of the dispensing mechanism is shut off from the outside air by the cover.

[0004]

By the way, the above-mentioned automatic analyzers are available in various shapes, such as those in which a sample container and a reaction container are arranged in a straight line, and those in which a sample container and the like are mounted on a disk-shaped member. Some are arranged in a circle. In an automatic analyzer in which sample containers and the like are linearly arranged, the gas suction direction can be set to a specific one direction, and the gas suction mechanism described in the above publication can be easily applied.

[0005] However, in an automatic analyzer in which sample containers and the like are arranged in a circular shape, the direction of gas suction is large, so that it is not possible to set a specific one direction. Therefore, when applying the gas suction mechanism of the above publication, a large number of suction ducts are arranged according to a number of gas suction directions,
Alternatively, a large suction system must be employed. This requires significant improvements to the automated analyzer,
The configuration is complicated and large, and the price is greatly increased.

Further, in the gas suction mechanism disclosed in the above publication, a filter for adsorbing the mist sample is detachable, but this filter sucks the harmful sample. For this reason, sufficient care must be taken to replace this filter, and maintenance and handling are troublesome.

Further, in the automatic analyzer described in the above-mentioned publication, no consideration is given to the display of the filter replacement time, and there is a possibility that the filter replacement will be delayed and sufficient adsorption capacity cannot be exhibited. there were.

[0008] An object of the present invention is to effectively aspirate harmful aerosol generated in an automatic analyzer with a simple structure,
In addition, an object of the present invention is to realize an automatic analyzer that can be easily and safely maintained and handled.

[0009]

The present invention is configured as follows to achieve the above object. In an automatic analyzer that dispenses a liquid sample such as blood or urine by a dispensing mechanism into a reaction container arranged on a peripheral portion of a cylindrical reaction disk and analyzes the liquid sample, the liquid analyzer has a cylindrical shape having a hollow portion. A number of suction ports communicating with the hollow portion are formed in the side wall portion, and an aerosol suction duct disposed in the center portion of the reaction disk, and a second portion disposed in the hollow portion of the suction duct and detachable from the suction duct. And a gas flow path formed between the first filter and the main body of the automatic analyzer and communicating the outside of the main body with the hollow portion of the suction duct through the first filter, and the gas from the suction port of the suction duct. A gas moving means for moving the gas to the outside via the flow path, and a second filter arranged near the gas outlet of the gas flow path are provided.

Preferably, there is provided a gas movement control means for controlling the operation of the gas movement means in conjunction with the liquid sample analysis operation. Preferably, an integrating means for integrating the operating time of the gas moving means, and means for determining whether the operating time integrated by the integrating means has reached a predetermined time,
Display means for displaying that the first or second filter is to be replaced based on the determination by the determination means.

Preferably, storage means for storing the replacement time of the first and second filters or the integrated operation time of the gas moving means, and a filter based on the replacement time or the integrated operation time stored in the storage means. A replacement time determining unit for determining the replacement time of the filter, a display means for displaying that the filter is to be replaced according to the determination of the replacement time determining unit, and based on an operator's command supplied via the console, An analysis start / stop / end determination unit that determines the start, stop, and end of the analysis, and operates in accordance with a signal supplied from the analysis start / stop / end determination unit. An operation start / stop determination unit for stopping the operation of the gas moving unit after a predetermined time elapses after the stop and termination. Further, preferably, the first filter is a filter capable of collecting aerosol having a particle size of 1 micron or more, and the second filter is a filter capable of collecting aerosol having a particle size of 0.3 micron or more. It is.

[0012]

The infectious aerosol present around the reaction disk is sucked from multiple directions into the aerosol suction duct by the gas moving means. The aerosol component having a large particle size out of the aerosol sucked is removed by the first filter. The aerosol that has passed through the first filter moves from the gas flow path to the second filter. The aerosol is almost completely removed by the second filter, and the gas containing no infectious aerosol is discharged out of the main body of the automatic analyzer. The first filter is easily detachable from the suction duct. As a result, harmful aerosols generated in the automatic analyzer are effectively sucked in with a simple configuration, and maintenance and handling are easy and safe.

[0013]

Embodiments of the present invention will be described below with reference to the accompanying drawings.

FIG. 1 is a schematic configuration diagram of an automatic analyzer according to one embodiment of the present invention. In FIG. 1, reference numeral 1 denotes a reaction disk, and the reaction disk 1 is driven to rotate by a rotation driving mechanism (not shown). A large number of reaction vessels 2 are arranged on the outer periphery of the reaction disk 1. The entire reaction disk 1 is maintained at a predetermined temperature by the reaction tank 3 and the thermostat 4. At the center of the reaction disk 1, a cylindrical aerosol suction duct 5 having a hollow portion is provided. 6 is a sample sample disk mechanism,
In this mechanism 6, a number of sample cups 7 are arranged in a circle. The sample in the sample cup 7 is appropriately extracted by the probe 8 a of the sample pipetting mechanism 8 and injected into a predetermined reaction vessel 2. Reference numeral 9 denotes a reagent disk mechanism provided with a plurality of reagent bins 10, and a reagent pipetting mechanism 11 is disposed near the reagent disk mechanism 9. 11a is a probe of the reagent pipetting mechanism 11. Reference numeral 12 denotes a reagent bar code reader. The reagent bar code reader 12 is arranged close to the reagent disk mechanism 9 and reads an ID code displayed on the reagent bin 10. Further, near the reaction tank 3 and the reagent disk mechanism 9, a stirring mechanism 13 for mixing the reagent and the sample in the reaction vessel 2 is arranged. Reference numeral 14 denotes a multi-wavelength photometer, and the reaction container 2 for accommodating a photometric object is disposed between the multi-wavelength photometer 14 and a light source (not shown). Further, a washing mechanism 15 is arranged near the reaction tank 3 for washing the reaction container 2 after the measurement.

Next, a control system and a signal processing system of the automatic analyzer will be described. 16 is a computer, 17 is an interface, 18 is an A / D converter, 19 is a reagent dispensing mechanism, 20 is a washing water pump, and 21 is a sample dispensing mechanism.
Reference numeral 22 denotes a printer, 23 denotes a CRT, 24 denotes a floppy disk as a storage device, and 25 denotes a keyboard.

The basic operation of the automatic analyzer having the above configuration will be described. The sample cup 7 containing the sample is
A plurality of samples are placed on the sample disk 6 in a circle. The rotation of the sample sample disk 6 is controlled by the computer 16 via the interface 17. The sample disk 6 is rotated so that the required sample cup 7 moves to a position below the sample dispensing probe 8a. Subsequently, the sample in the sample cup 7 is sucked by the pump of the sample dispensing mechanism 21 to which the probe 8a is connected, and is dispensed into the reaction container 2 by a predetermined amount. The reaction container 2 into which the sample has been dispensed is moved to the first reagent addition position while being held by the reaction tank 3 connected to the constant temperature bath 4. A predetermined first reagent is added to the reaction container 2 moved to the first reagent addition position. This first
The reagent is sucked from the reagent bin 10 arranged on the reagent disk 9 to the reagent dispensing probe 11a by the action of the pump of the reagent dispensing mechanism 19. Then, the reagent in the reaction container 2 and the sample are mixed by the stirring mechanism 13. After the addition of the first reagent, the second reagent is similarly added and agitated, and after about 10 minutes, the reaction vessel 2 is moved to the measurement location and the light beam emitted from the light source is passed. At this time, the optical physical quantity is detected by the multi-wavelength photometer 14. A signal related to the detected optical physical quantity is converted into a digital signal by an A / D converter 18 and input to a computer 16 via an interface 17. Then, the concentration of the measurement target in the measurement sample is calculated based on the signal input to the computer 16. The calculated density data is printed out by the printer 22 through the interface 17 or is output as a CR.
It is displayed on the screen of T23. After the completion of the measurement, the reaction container 2 is moved to the position of the washing mechanism 15 where the sample inside is discharged by the washing water pump 20 and then washed with washing water. The keyboard 25 is used for inputting predetermined commands and analysis conditions by the operator. The floppy disk 24 is used as a means for reading the system, collectively storing analysis data, and the like.

FIG. 2 is an external view of the automatic analyzer. In FIG. 2, the analyzing unit 33 is in a state in which the lid 26 is closed in principle while the measurement of the sample is being performed (however, it is not necessary to be in a closed state). The operation unit 34 can be remotely operated because it is independent of the analysis unit 33. Further, the CRT 23 allows the user to check the measurement progress. In the analysis section 33, the floppy disk 2
A power switch is arranged near the arrangement position of No. 4.

FIG. 3 is a partially cutaway side view of the automatic analyzer, showing a configuration for discharging the aerosol generated in the analyzer 33 to the outside. In FIG. 3, when a fan 27 as a blower is rotated by a rotating device (fan motor),
Gas is sucked from the aerosol suction duct 5 at the center of the reaction disk 1 (suction at a wind speed of 0.38 m / s or more), and an air flow is generated as shown by an arrow 28 in the gas flow path 29. Therefore, air containing infectious aerosol around the analysis section is discharged to the outside from the back side of the automatic analyzer by such a gas flow. A pre-filter 30 is disposed near the inlet of the gas flow path 29, and a HEPA filter (High Efficiency Particulate Air) is disposed near the air outlet 31.
Filter) 32 is disposed. First, pre-filter 3
When 0, an aerosol having a large particle size (1 micron or more) is collected. Next, even smaller particles are collected by the HEPA filter 32 (particles of 0.3 microns or more are collected by 99.7).
% Collection), and only completely purified air is discharged to the outside.

Next, the detailed structure of the aerosol suction duct 5 will be described with reference to FIGS. First, as shown in FIG. 4A, the reaction disk 1 has a donut-shaped reaction tank 3 and a reaction vessel 2 on the outer periphery thereof. Therefore, since the center of the reaction disk 1 is hollow, the aerosol suction duct 5 is disposed on the center, as shown in FIG. 4B. The aerosol suction duct 5 has a cylindrical shape, and its side wall 5a has a bellows shape, so that the surrounding air can be sucked from a 360-degree direction. Therefore, as shown in the overall view of the analyzer of FIG. 1, the aerosol suction duct 5 is provided at all points where sample-derived infectious aerosol is generated (sample pipetting mechanism 11, stirring mechanism 13, washing mechanism 15, etc.). The aerosol can be effectively sucked in simply by installing one.

Next, as shown in FIG. 5, a lid 5b is detachably disposed on the upper surface of the aerosol suction duct 5, and when the lid 5b is removed from the duct 5, the pre-filter 30 can be easily taken out. It has become. As the material of the prefilter 30, a nitrocellulose type, a cellulose acetate type, or the like is suitable, and sterilization can be performed several times by a high-pressure steam sterilizer or the like. This pre-filter 30
, The life of the HEPA filter 32 can be extended. Also, the aerosol suction duct 5
Can be easily removed from the reaction disk 1, and sterilization can be performed as it is.

According to the above embodiment, in an automatic analyzer in which sample containers and the like are arranged in a circle, attention is paid to the fact that the shape of the reaction disk 1 is disk-shaped and the center is hollow, and In addition, a suction duct 5 for sucking gas from a peripheral portion is disposed. Thus, the infectious aerosol generated around the analysis section is sucked from various directions by the aerosol suction duct 5, and the gas after being removed through the pre-filter 30 and the HEPA filter 32 is discharged to the outside. Further, the pre-filter 30 can be easily taken out from the suction duct 5 and can be easily replaced. Therefore, an automatic analyzer that can prevent the secondary infection of the operator and ensure safety with a simple configuration without significant improvement can be realized.

In the above embodiment, the suction operation of the aerosol suction duct, that is, the rotational drive of the fan 27 is continuously performed from the time the power switch of the main body is turned on until the power switch is turned off. Alternatively, it may be performed in conjunction with the analysis operation. If the rotation drive of the fan 27 is performed in conjunction with the analysis operation, the gas in the automatic analyzer can be sucked only when it is necessary to suck the gas, thereby saving power and extending the life of the fan motor and the like. Can be achieved. Further, by avoiding continuous suction for a long time, unnecessary evaporation of a sample or the like can be avoided.

FIG. 6 is a diagram for explaining the operation of the entire automatic analyzer according to another embodiment of the present invention, in which the fan 27 is driven to rotate in conjunction with the analysis operation. The analysis unit 33
The basic configuration of the operation unit 34 is the same as the example of FIG.

In FIG. 6, in step 100,
The power switch of the main body of the automatic analyzer is turned on. Then, in step 101, the preparation operation of the analysis unit 33,
For example, the temperature of the reaction disk 1 is raised to a predetermined temperature, and the positions of the sample dispensing mechanism 21 and the sample sample disk mechanism 6 are adjusted. Is also displayed). In step 200, the fan 27 is rotationally driven in conjunction with the preparation operation.
When the preparation operation is completed, in step 102, the system enters a standby state, which is a standby state until the analysis operation is started. In conjunction with this, the fan 27 determines in step 20
At 1, the state is stopped.

Next, when the analysis operation is started in step 103, the fan 27 is rotationally driven in step 202. When the predetermined analysis operation is completed, the fan 27 is rotationally driven for 10 minutes after the completion of the analysis operation, and then stopped. This is to sufficiently discharge the infectious aerosol remaining in the analysis section 33. And
At step 104, the system enters a standby state. If this standby state continues for 10 minutes or more, step 2
At 03, the fan 27 is driven to rotate for one minute every ten minutes. This is to prevent contamination in the analyzer 33 due to spontaneous evaporation of the sample or the like.

When the analysis is resumed in step 105, the rotational driving of the fan 27 is started in step 204. Then, when the analysis is completed and the cleaning process is completed, the fan 27 is operated for 10 minutes after the completion of the cleaning process.
Is stopped after being rotated. This is for the same reason as described above. Thereafter, in step 106, the power of the automatic analyzer is automatically turned off (automatic shutdown function).

Next, the microcomputer 16 (gas movement control means) for executing the operation of the example of FIG. 6 described above.
The function and the operation flow will be described.

FIG. 7 is a functional block diagram of the microcomputer 16, and FIG.
4 is an operation flowchart of FIG. 7 and 8, when the power switch 38 is turned on, a signal Son indicating this is supplied to the power-on determination unit 161 of the microcomputer 16 via the interface 17. The power-on determining section 161 supplies the start signal So to the replacement time determining section 162. Then, the replacement time determination unit 162
Determines whether it is time to replace the filters 30 and 32 in step 300 of FIG. That is, the memory (integrating means) 165 stores the replacement time of the filters 30 and 32 or the integrated operating time of the fan motor (gas moving means) 39, and based on the stored contents, the replacement time determining unit 162 determines Determine when to replace. If it is time for replacement, the process proceeds to step 301, where a replacement display signal Sd is supplied to the CRT 23 via the interface 17. Then, a warning display for replacing the filter is displayed on the CRT 23.

If it is not time to replace the filter, the replacement time determination unit 162 supplies an operation start signal Ss to the fan motor operation start / stop determination unit 163. Then, in step 302, the start / stop determining unit 163 supplies the fan motor drive signal Sf to the fan motor 39. Thus, the rotation of the fan 27 is started. 35 is a temperature sensor for detecting the temperature of the reaction disk 1, and 36 is
This is a position sensor that detects the position of the sample dispensing mechanism 21 and the like. The start / stop judging section 163 is supplied with signals such as the temperature signal St from the temperature sensor 35 and the position signal Sp from the position sensor 36. The start / stop determining unit 163 determines in step 303 whether or not the preparation operation of the analyzing unit 33 has been completed based on the signal St and the like.

When the preparation operation of the analysis unit 33 is completed, the start / stop determination unit 163 stops the fan motor 39 in step 304. Then, the process proceeds to step 305 to be in a standby state until the start of analysis. 164 is
An analysis start / stop / end determination unit. This judgment unit 164
Is supplied from the keyboard 25 via the interface 17 with a signal Sc indicating the start, stop, and end of the analysis. Then, the determination unit 164 supplies a signal Sj indicating start, stop, and end of the analysis to the start / stop determination unit 163 based on the supplied signal Sc. Start / stop determination unit 16
3 determines in step 305 whether or not the analysis has been started according to the signal Sj. When the analysis is started, the process proceeds to step 306, where the fan motor 39 is driven. continue,
In step 307, the start / stop determining unit 163 determines whether or not the analysis has been stopped based on the signal Sj, and if not stopped, maintains the rotational driving state of the fan motor. When the analysis is stopped, the process proceeds to step 308, and it is determined whether 10 minutes have elapsed since the stop. If 10 minutes have not elapsed, the apparatus enters a standby state, and after that, proceeds to step 309 to stop the fan motor 39.

Next, the routine proceeds to step 310, where it is determined whether or not the analysis has been completed. If the analysis is completed, in step 311, the analysis start / stop / end determination unit 164 sends the power-off signal Se via the interface 17 to the power supply circuit 37.
To supply. Then, the power of the automatic analyzer is turned off. In step 310, if the analysis has not been completed, the process of the start / stop determining unit 163 proceeds to step 312, and determines whether ten minutes have elapsed since the fan motor was stopped. If 10 minutes have not elapsed, the process proceeds to step 313, and it is determined whether or not the analysis has been restarted. If the analysis is to be resumed, proceed to step 306,
Thereafter, the same processing as described above is performed. Step 3
In 13, if the analysis is not resumed, the process returns to step 312. In this step 312, if ten minutes have elapsed since the fan motor was stopped, the routine proceeds to step 314, where the fan motor 39 is driven. Then, in step 315, the fan motor 39 is driven until one minute has elapsed since the drive of the fan motor 39. Fan motor 39
When one minute has passed since the drive of the motor, the flow returns to step 309, and the fan motor 39 is stopped. Thereafter, the fan motor 39 is stopped for one minute every 10 minutes until the analysis is completed or the analysis is restarted. Are driven intermittently.

As described above, according to the examples shown in FIGS. 6 to 8, in addition to the same effects as those of the example shown in FIG. 1, the following effects can be obtained. Since the fan motor 39 is driven in conjunction with the analysis operation of the analysis unit 33 and the aerosol suction operation is performed, the gas in the analysis unit 33 can be sucked only when necessary. It is possible to save power and extend the life of a fan motor or the like. Further, by avoiding continuous suction for a long time, unnecessary evaporation of a sample or the like can be avoided. Further, when it is time to replace the filters 30 and 32, a warning display indicating the replacement is automatically performed, so that the filter can be replaced at an appropriate time, and the filter can be sufficiently absorbed. We can show ability.

In the above-described embodiment, the fan motor 39 is driven only for 10 minutes after the analysis is stopped and completed. However, the fan motor 39 is driven for another time interval instead of 10 minutes. You may. Also,
Although the fan motor 39 is driven intermittently for one minute every ten minutes, it may be driven intermittently at other time intervals. Further, it may be configured such that whether or not the aerosol suction operation is linked to the analysis operation can be selected. Further, the replacement time of the filters 30 and 32 may be set, for example, six months after the replacement, or may be the time when the aerosol suction operation time is integrated and the integrated time reaches a predetermined time.

FIG. 9 shows the CRT 2 in the standby state.
3 is a display example. In FIG. 9, it is possible to select or designate on the CRT 23 whether or not to link the aerosol suction operation with the separative operation. FIG. 10 is a display example on the CRT 23 for warning that the filters 30 and 32 need to be replaced. In FIG. 10, the last replacement date of the filters 30 and 32 is displayed, and when the replacement time comes, a warning display such as blinking of the last replacement date is performed.

As shown in FIGS. 9 and 10, the operability of the automatic analyzer can be improved by displaying the designation of the aerosol suction operation and the replacement time of the filter.

[0036]

Since the present invention is configured as described above, it has the following effects. An aerosol suction duct having a plurality of suction ports communicating with the hollow portion of the reaction disk on the side wall portion, a first filter detachable from the suction duct, an outside of the automatic analyzer main body, and a hollow of the suction duct. A gas passage communicating with the gas passage, a gas moving means for moving gas in the gas passage toward the outside, and a second filter arranged near a gas outlet of the gas passage. Thereby, the infectious aerosol generated around the analysis unit is sucked from various directions by the aerosol suction duct, and the gas after being removed through the first filter and the second filter is discharged to the outside. Also, the first
This filter can be easily taken out from the suction duct 5 and can be easily replaced. Therefore,
An automatic analyzer that can prevent secondary infection of an operator and ensure safety with a simple configuration without significant improvement is realized.

Further, in conjunction with the liquid sample analysis operation,
If the apparatus is provided with the gas movement control means for controlling the operation of the gas movement means, the gas in the analysis section can be sucked only when suction is necessary, thereby saving power and reducing the length of the gas movement means such as a fan motor. Life can be extended.
Further, by avoiding continuous suction for a long time, unnecessary evaporation of a sample or the like can be avoided.

Further, if the filter is replaced, it is possible to perform the replacement of the filter at an appropriate time by automatically displaying a warning indicating the replacement, so that the filter can be sufficiently absorbed. We can show ability.

[Brief description of the drawings]

FIG. 1 is a schematic configuration diagram of an automatic analyzer according to one embodiment of the present invention.

FIG. 2 is a schematic external view of the example of FIG.

FIG. 3 is a partially cutaway side view of the analysis unit of the example of FIG. 1;

FIG. 4 is an explanatory view of an aerosol suction duct.

FIG. 5 is a schematic exploded perspective view of an aerosol suction duct.

FIG. 6 is an overall operation explanatory view of an automatic analyzer according to another embodiment of the present invention.

7 is a functional block diagram of the microcomputer in the example of FIG.

8 is an operation flowchart of the microcomputer in the example of FIG.

FIG. 9 is a diagram illustrating a display example of a CRT in a standby state.

FIG. 10 is a diagram illustrating a display example of a CRT that warns of filter replacement.

[Explanation of symbols]

 REFERENCE SIGNS LIST 1 reaction disk 2 reaction vessel 5 aerosol suction duct 6 sample disk mechanism 7 sample cup 8 sample pipetting mechanism 9 reagent disk mechanism 10 reagent bottle 11 reagent pipetting mechanism 14 multiwavelength photometer 16 microcomputer 17 interface S 19 Reagent dispensing mechanism 21 Sample dispensing mechanism 23 CRT 25 Keyboard 27 Fan 29 Gas flow path 30 Prefilter 32 HEPA filter 33 Analysis unit 34 Operation unit 39 Fan motor 161 Power-on judgment unit 162 Replacement time judgment unit 163 Fan motor operation start / stop determination unit 164 Analysis start / stop / end determination unit 165 Memory

Claims (5)

(57) [Claims] 1. An automatic analyzer for dispensing a liquid sample such as blood, urine or the like by a dispensing mechanism into a reaction container arranged on a peripheral portion of a cylindrical reaction disk, and analyzing the liquid sample. A plurality of suction ports communicating with the hollow portion are formed in the side wall portion, and an aerosol suction duct disposed in the center portion of the reaction disk, and disposed in the hollow portion of the suction duct. A first filter detachable from the suction duct, and a gas flow formed in the main body of the automatic analyzer and communicating the outside of the main body with the hollow portion of the suction duct via the first filter. A path, gas moving means for moving gas from the suction port of the suction duct to the outside through the gas flow path, and a second filter disposed near the gas outlet of the gas flow path. Specially to prepare Automatic analyzer 2. The automatic analyzer according to claim 1, wherein
An automatic analyzer, comprising: a gas transfer control unit that controls an operation of the gas transfer unit in conjunction with a liquid sample analysis operation. 3. The automatic analyzer according to claim 1, wherein an integrating means for integrating the operating time of the gas moving means, and whether the operating time integrated by the integrating means has reached a predetermined time. An automatic analyzer comprising: a determination unit configured to determine whether the first or second filter is to be replaced based on the determination by the determination unit. 4. The automatic analyzer according to claim 1, wherein storage means for storing replacement time of the first and second filters or integrated operation time of the gas moving means, and replacement time stored in the storage means. Or, based on the accumulated operation time, a replacement time determination unit that determines the replacement time of the filter, display means for displaying that the filter is time to replace according to the determination of the replacement time determination unit, Analysis start / stop / end judgment unit that judges the start, stop, and end of analysis based on the supplied operator's command, and operates according to signals supplied from analysis start / stop / end judgment unit to start analysis. Driving the gas moving means in accordance with, after the analysis stop and end, the operation start / stop determination unit of the gas moving means to stop the operation of the gas moving means after a predetermined time has elapsed, Automatic analyzer. 5. The automatic analyzer according to claim 1, wherein the first filter is a filter capable of collecting aerosol having a particle size of 1 μm or more, and the second filter is An automatic analyzer characterized by being a filter capable of collecting aerosol having a particle size of 0.3 microns or more.