JP2572994B2 - Acaricide containing dimethylalkyl betaine as an active ingredient - Google Patents

Description

Description: TECHNICAL FIELD The present invention relates to an acaricide and an acaricide containing dimethylalkyl betaine.

[Background Art] House dust mites are found everywhere indoors, and their habitat extends not only to tatami mats and carpets but also to sofas, stuffed animals and bedding. Conventionally, as acaricides against such house dust mites, phosphorus compounds such as fenitrothion, fenthion, DDVP, and diazinon, propoxers, carbamate compounds such as NAC, and pyrethroid compounds such as resmethrin are known. .

[Problems to be solved by the invention]

These known acaricides are used on tatami mats, carpet repellent paper, or sprayed or sprayed as they are, but phosphorus-based and carbamate-based acaricides are highly toxic and have a low effect on Dermatophagoides. Therefore, the scope and amount of application are limited. In addition, since pyrethroids are expensive and slow-acting, their application method and amount are limited. It has various disadvantages.

The present inventors have conducted intensive studies to solve the problems of the prior art, and found that dimethyl alkyl betaine, an amphoteric surfactant used in textiles and cosmetics for the purpose of preventing static electricity and imparting flexibility. When an active ingredient is used as an active ingredient, the above-mentioned drawbacks of the conventional acaricide are completely eliminated, a low toxicity and excellent safety for the human body, and an acaricide effective for all kinds of mites such as Dermatophagoides are found. The present invention has been completed.

[Means for solving the problem]

That is, the present invention provides: Wherein n represents 8 to 24. The present invention relates to an acaricide characterized by containing a dimethylalkylbetaine represented by the following formula: The mites to be controlled in the present invention may be of any type, but in particular, house dust mites such as Dermatophagoides farinae and Dermatophagoides pteronyssinus, mites such as Dermatophagoides farinae and Dermatophagoides farinae; Examples of the mites include a house dust mite such as a house dust mite and a house mite, and animal parasitic mites such as a house mite and a bird mite. Although the acaricide of the present invention can be used as it is, it is usually retained on a liquid carrier and a solid carrier, and if necessary, a film forming agent, an emulsifier, a dispersant, a spreading agent, a wetting agent, a stabilizer, and a propellant. And a volatilization modifier, etc., and can be used in the form of oils, emulsions, aqueous solutions, wettable powders, sprays, aerosols, smokers, coatings, powders, granules and the like.

As the liquid carrier, water or, for example, methyl alcohol,
Ethanol, alcohols such as isopropyl alcohol, acetone, methyl ethyl ketone, ketones such as cyclohexanone, tetrahydrofuran, dioxane,
Ethers such as dimethyl ether, aliphatic hydrocarbons such as hexane, kerosene, normal paraffin, and solvent naphtha; aromatic hydrocarbons such as benzene and toluene; halogenated hydrocarbons such as dichloromethane and dichloroethane; ethyl acetate; butyl acetate And CFC-based solvents (CFC 113, CFC 114 B2, CFC 21, CFC 10, etc.). As a solid carrier,
For example, silicic acid, kaolin, activated carbon, bentonite, diatomaceous earth, talc, clay, calcium carbonate, mineral powders such as porcelain powder, wood powder, soybean powder, flour, plant powders such as starch, inclusion compounds such as cyclodextrin And the like.

Examples of the coating film forming agent include cellulose derivatives, vinyl resins, alkyd resins, urea resins, epoxy resins, polyester resins, urethane resins, silicone resins, acrylic resins, chlorinated rubbers, polyvinyl alcohol, and the like. As emulsifiers, dispersants, and spreading agents, soaps, polyoxyethylene fatty alcohol ethers, polyoxyethylene alkyl allyl ethers, polyoxyethylene fatty acid esters, fatty acid glycerides, sorbitan fatty acid esters, sulfuric acid esters of higher alcohols, Surfactants such as alkyl allyl sulfonates and propellants include liquefied petroleum gas, dimethyl ether, fluorocarbon and the like. Further, as a volatilization modifier, sublimable carriers such as tricyclodecane, cyclododecane, 2,4,6-triisopropyl-1,3,5-trioxane, trimethylene norbornene, and sublimable carriers such as paradichlorobenzene and naphthalene π-camphor. Using an insect repellent, the mite control composition can also be used as a sublimable solid agent, empenthrin,
A volatile insecticide such as DDVP can be combined and used as a volatile mite control agent.

Further, the acaricide of the present invention may contain various insect repellents, synergists, pest repellents, rodent repellents, antioxidants, antidegradants, bactericides, fungicides, fragrances, coloring agents, and the like. it can. Insect repellents that can be blended include 3-allyl-2-methylcyclopenta-2-en-4-one-1-yl d1-
Cis / trans-chrysanthemate, 3-allyl-2-
Methylcyclopenta-2-en-4-one-1-yl
d-cis / trans-chrysanthemate, d-3-allyl-2-methylcyclopenta-2-en-4-one-1
-Yl d-trans-chrysanthemate, 3-allyl-2-methylcyclopenta-2-en-4-one-1-
Il d-trans-chrysanthemate, N- (3.4
* 5.6-tetrahydrophthalimide) -methyl d1-cis / trans-chrysanthemate, 5-benzyl-3-
Furylmethyl d-cis / trans-chrysanthemate, 5- (2-propargyl) -3-furylmethylchrysanthemate, 3-phenoxybenzyl 2.2-dimethyl-3- (2'-2'-dichloro) vinyl Cyclopropanecarboxylate, 3-phenoxybenzyl d-cis / trans-chrysanthemate, α-cyanophenoxybenzyl isopropyl-4-chlorophenylacetate, d-3-allyl-2-methylcyclopenta-2-
Ene-4-one-1-yl d-trans-chrysanthemate, (S) -α-cyano-3-phenoxybenzyl (1R · cis) -3- (2.2-dichlorovinyl) -2 ·
2-dimethylcyclopropanecarboxylate, (R.
S) -α-cyano-3-phenoxybenzyl (1R · 1
S) -cis / trans-3- (2.2-dichlorovinyl) -2-2.2-dimethylcyclopropanecarboxylate, α-cyano-3-phenoxybenzyl d-cis /
Trans-chrysanthemate, 1-ethynyl-2-methyl-2-pentenyl cis / trans-chrysanthemate, 1-ethynyl-2-methyl-2-pentenyl, 2.
2-dimethyl-3- (2-methyl-1-propenyl) cyclopropane-1-carboxylate, 1-ethynyl-
2-methyl-2-pentenyl 2,2,3-tetramethylcyclopropanecarboxylate, 1-ethynyl-2-methyl-2-pentenyl 2.2-dimethyl-3
-(2.2-dichlorovinyl) cyclopropane-1-carboxylate, 0.0-dimethyl 0- (2.2-dichloro) vinyl phosphate, 0-isopropoxyphenylmethylcarbamate, 0.0-dimethyl 0- ( 3
-Methyl-4-nitrophenyl) thionophosphate, 0.0-diethyl 0-2-isopropyl-4-methyl-pyrimidyl- (6) -thiophosphate, 0.
0-dimethyl S- (1.2-diorboethoxyethyl) -dithiophosphate, benzylbenzoate and the like, and as a synergist, 6- (propylpiperonyl)-
Butyl carbyl ether, N- (2-ethylhexyl) -1-isopropyl-4-methylbicyclo (2,2,
2) Oct-5-ene-2,3-dicarboximide, isobornyl thiocyanoacetate, octachlorodipropyl ether and the like;
(Fluorodichloromethylthio) -phthalimide, N, N
-Dimethyl-N'-phenyl-N '-(fluorodichloromethylthio) sulfamide, 2,4,4'-trichloro-
Examples thereof include 2'-hydroxydiphenyl ether, 0-phenylphenol, P-chloro-m-xylenol, 4-chlorophenyl-3'-iodopropargyl formal and the like.

The amount of the active ingredient in the acaricide of the present invention may be appropriately determined according to the dosage form, application method, application place, and the like,
When used in the form of aqueous solutions, wettable powders, emulsions, coatings, powders, granules, etc., 0.1 to 35% by weight of the active ingredient, sprays,
Fumigants, if used in the form of oil or aerosol, preferably to 0.1 to 10% by weight of the active ingredient, the amount applied, the active ingredient in an area 1 m ² per be processed about 10mg or more, apply cause the presence of active ingredient from about 1mg or more per space 1 m ² is desirable.

The present invention also provides a tick control material comprising the above-mentioned acaricide held on a substrate. The mite controlling material is a film having mite controlling properties by utilizing the properties of the base material,
It is used as a seat, cushion, bedding filler, building and construction material, and the like. Here, as the substrate, for example, polyethylene / polypropylene, nylon, polyvinyl chloride,
Synthetic resin sheet of polyvinylidene chloride, polyester, etc., animal or plant material or inorganic fiber sheet (paper, cloth, non-woven fabric, leather, etc.), mixed sheet or blended cloth of these synthetic resin and inorganic fiber or powder, and the above synthetic resin Examples thereof include a blended or nonwoven fabric with animal and plant fibers, a foil or film of a metal such as aluminum, stainless steel, and zinc, and a laminated sheet of the above various sheets. As cushions and bedding fillers, natural cotton (cotton, cotton, etc.), synthetic fiber cotton (polyester cotton, nylon cotton, acrylic cotton, etc.), feathers and other animal hair, buckwheat hull, rice hull, grain straw, foam plastic (Polyethylene foam, urethane foam, etc.).

Further, as the above-mentioned base material, natural woods used as building / construction materials, such as drills, pencil ferns, and so on, and plastics, such as vinyl chloride resin, chlorinated polyethylene, polyethylene, and polypropylene, can be effectively used.
Means for holding the mite control agent of the present invention on these substrates is not particularly limited, and may be performed by, for example, application, impregnation, dropping, spraying, kneading, or the like. The retention amount is not particularly limited and can be appropriately determined. However, in the case where the substrate is impregnated, the amount is preferably up to the saturated impregnation amount.

As a preferred embodiment of the tick control material of the present invention, a tick control carpet can be exemplified. The mite control carpet according to the present invention has a liquid form in which a normal carpet comprising, for example, a pile, a first base fabric, a packing agent and a second base fabric is prepared, and then a film-forming agent is added as required. Spraying an agent, or prior to preparing the carpet, treating at least one of a pile, a first base cloth and a second base cloth with the acaricide of the present invention, and preparing a carpet using these. Is obtained by The mite control carpet prepared as described above desirably holds about 0.1 to 10 g of the active ingredient per 1 m ^{2 of} carpet area. or,
As another embodiment, a tick control futon and a pillow can be exemplified. The mite control quilt and pillow are obtained by spray-coating the acaricide of the present invention on a filler such as natural cotton, synthetic fiber cotton, feathers or other animal hair, buckwheat husk, rice hull, cereal straw, foamed plastic and the like. Can be The mite control futon and pillow created as described above are about 0.1 to 10 g per 1 kg of filler weight.
May be retained.

[Action]

The acaricide and the acaricide of the present invention exhibit extremely excellent effects based on the fact that they contain dimethylalkylbetaine represented by the above general formula as an active ingredient.

〔Example〕

 Hereinafter, the present invention will be described in more detail with reference to examples.

Example 1 Efficacy against Dermatophagoides farinae A nonwoven fabric (made of polypropylene, 230 μm in thickness) is cut into a size of 5 × 5 cm, and impregnated with an acetone solution of a test compound to a predetermined concentration. After removing the solvent, apply this impregnated cloth to about 300
Put it in a polyethylene bag (6 x 6 cm) together with the test mites on the head, and make the four sides adhere closely. After 48 hours, life and death were determined under a stereoscopic microscope. The results were obtained as mortality (%) by Abbott correction of the following formula and are shown in Table 1.

x; Percentage of live insects in untreated plot y; 〃 in treated plot The acaricide of the present invention showed a higher effect than resmethrin.

Example 2 Specification Nos. A to
In I, a carpet-shaped mite control material of the present invention was prepared.

Mite control carpet samples No. A to I obtained above
The following test was conducted.

<Test Method> A tick culture medium containing about 10,000 Dermatophagoides farinae was placed in the center of carpet samples No. A to I and a carpet without treatment (each 20 × 20 cm), and this was placed in a container (41 ×
31 × 22cm) After put in the bottom, 2 ℃ under the condition of 25 ℃ and 64% RH
After storage for 2 days, 200mesh nylon goose 2
The mite on the front or back of the carpet was sucked off with a vacuum cleaner between the sheets. Next, remove the nylon goose from the vacuum cleaner,
The mites are brushed off into a 300 ml beaker containing 100 ml of Darling solution, transferred to a centrifuge tube after stirring, centrifuged at 1000 rpm, and the supernatant is transferred to a Buchner funnel with a seal paper and passed through a suction port. Surviving mites on this paper were counted, and the result was obtained as the mortality (%) from the following equation.

x: Number of surviving mites in the carpet group without treatment y; Number of surviving mites in the carpet group for controlling mite The above test was repeated three times, and the results are shown in Table 3 as average values.

As shown in Table 3 above, each sample showed sufficient mite control.

Example 3 To 10 g of each of the following test compound sample Nos. A to G, a trace amount of fragrance and 20 ml of ethyl alcohol were added, and distilled water was further added to make a total of 150 ml. This was mixed with a liquefied petroleum gas and dimethyl ether mixture (1 (Volume ratio: 1: 1 by volume) into a pressure-resistant can for aerosol (content: 400 ml), attached to an injection device, and sealed to obtain the acaricide of the present invention in the form of an aerosol.

Using each of the aerosols thus obtained, the mite control effect was tested in the same manner as in Example 1.

<Test method> Spray each aerosol on a high-quality paper (30 x 30 cm) for 3 seconds so as to be as uniform as possible. After storing at room temperature for 1 day,
A sheet having a size of 5 × 5 cm was cut out, and the mite control effect was tested according to the test method of Example 1 below.

The above test was repeated three times, and the results are shown in Table 4 as average values.

As shown in Table 4 above, each sample showed sufficient mite control.

Example 4. No. A to G of the test compound-mixed samples shown in Table 5 below were sprayed on futon cotton so that the test compound became 1 g / kg cotton, and then dried.
The mite control material of the present invention was obtained.

The following tests were performed on the mite-proof futon cotton samples Nos. A to G obtained above.

<Testing Method> 1 g of each of the futon cotton samples Nos. A to G is placed in a sample tube (30 ml), and about 500 Dermatophagoides farinae are placed in the tube and covered with the lid, and placed at 25 ° C. After 48 hours, cotton was taken out of the sample tube, and live mites were collected by a heat expulsion method, and the insect repellency (%) was determined by the following equation.

x: Percentage of collected mites in the untreated area y; Percentage of collected mites in the treated area As a result, all the samples were able to obtain almost 100% insect repellency and showed sufficient mite control.

Example 5 The test compound of the present invention used in Example 3 was mixed with the same weight of silicon oxide, sufficiently stirred, and then powdered to obtain a powdered acaricide of the present invention.

The powder thus obtained was tested for its mite control effect by the following test method.

<Test method> After heat-killing a straw cut to a length of about 2 cm, put 5 g of the straw in a 100 ml Erlenmeyer flask, then add and mix 0.05 g of each powder, and mix at 25 ° C and 85 to 90% RH. And save for 1 day. Into this Erlenmeyer flask, about 400 Acarina mites were charged, and after storage for 2 days under the same conditions, living mites were expelled by a heat expulsion method, the number was counted, and the mortality was determined according to the test method of Example 2. Calculated.

As a result, all powders were able to obtain almost 100% mortality and showed sufficient mite control.

Example 6. Compounds A to A shown in Table 6 below in a vacuum paper pack.
After being impregnated with the acetone solution of I and dried, the mite control material of the present invention was obtained.

Tick control paper pack samples No. A to I obtained above
The following tests were conducted for

<Test method> After attaching the paper pack samples No. A to I and the untreated paper pack to a commercially available vacuum cleaner (suction power 160 W), loosen 20 g of cotton-like polyester short fiber as a substitute for indoor dust. After suction, the paper pack was taken out and sprayed with 3 ml of water. Further, about 200 mg of a mite breeding medium containing about 1000 Dermatophagoides farinae was placed in a paper pack, and then the paper pack was mounted again in a vacuum cleaner and placed at 25 ° C. and 75% RH for 2 weeks. Thereafter, the mites in the paper pack were collected by a saturated saline floatation method, and alive and dead were determined to determine the mortality (%).
The above test was repeated three times, and the results are shown in Table 7 as average values.

As shown in Table 7 above, each sample showed sufficient mite control.

〔The invention's effect〕

Since the acaricide of the present invention is low-toxic and safe for the human body, it can be used for rugs such as tatami mats and carpets, furniture such as sofas and closets, bedding such as futons and beds, and toys such as stuffed toys. Can be used safely even in places where they frequently come in contact, and the target mites can be of any type, but are particularly effective for Dermatophagoides, such as Dermatophagoides farinae and Dermatophagoides farinae. Have.

Claims (2)

(57) [Claims] (1) General formula (Wherein, n represents 8 to 24) A miticide comprising as an active ingredient dimethylalkyl betaine represented by the following formula: 2. The general formula (In the formula, n represents 8 to 24) A mite controlling material characterized by having a substrate containing a miticide containing dimethylalkyl betaine as an active ingredient represented by the following formula: