JP2519912B2 - Volatilization amount adjustment method - Google Patents

Description

TECHNICAL FIELD The present invention relates to a method for controlling the volatilization amount of a volatile drug solution.

[Conventional technology]

Conventionally, when the drug solution is volatilized, for example, when the drug solution is an aromatic, generally, a large amount of water and a surfactant are added to the aromatic in a container, and the lid is taken up during use to volatilize. In this case, since the fragrance is wrapped in the surfactant, the fragrance does not volatilize as desired, and the odor of the surfactant is mixed with the fragrance and an excessive container is required. Further, in the case of an aromatic agent using a gelling agent, the surface of the gelling agent becomes hard and the amount of volatilization gradually decreases, and the amount of volatilization does not change regardless of the fact that a considerable amount of aromatic agent still remains in the gelling agent. There is a drawback that the amount of the volatilization is small and a preferable and constant volatilization amount cannot be obtained throughout the period of use.

[Problems to be solved by the invention]

The purpose of the present invention is to appropriately adjust the volatilization amount of the drug in the container,
The purpose is to develop a volatilization method that can control the amount of volatilization so that a substantially constant amount of volatilization can be obtained for a certain period.

[Means for solving problems]

In order to achieve the above object, conventionally, if the lid of the hermetically sealed container is removed, the drug solution in the container is volatilized by capillarity directly from the paper or sponge, but the gas is transmitted, but the liquid Using a specific microporous film that does not permeate as a lid, it was found that the amount of volatilization changes as shown in the figure by leaving the container itself with the lid part facing upward, sideways or downward, and based on this finding, the present invention Has reached.

That is, the present invention stores a volatile drug solution in a container using a microporous film for a lid, and leaves the container with the lid part facing upward, sideways or downward, periodically or automatically and manually. It is a method for controlling the amount of volatilization of a drug.

The microporous film used in the present invention is permeable to gas but impermeable to liquid, has a large number of micropores of 1 μm or less, and has a thickness of several tens of μm to several hundred μm. The micropore size and thickness may be appropriately selected according to the amount of volatilization. A preferred specific example of such a material is a polyfluorinated ethylene film (Nitoflon NTF-5200, Nitto Denko Corporation, etc.), and an EV
A (Eva Flex Mitsui Petrochemical Co., Ltd.) etc. can also be used sufficiently. Figure 1 shows Nitoflon NTF-5200 with a thickness of 80 μm.
As a result of the experiment using the film, a container with a volatilization area of 45 mmφ was added with a thickening agent to a bouquet type fragrance of Takasago Aroma Co., Ltd. to make a viscous aromatic liquid. The amount of volatilization is shown when the film is oriented downward (FIG. 1), when it is oriented horizontally (2), and when it is oriented upward (3).
According to this, in the case of facing upward, the amount of volatilization is the smallest, and in the case of facing downward, it is the largest. Lateral orientation is in the middle, which is close to downward orientation.

Fig. 2 shows EVA film (Evaflex thickness 50 μm)
It is the same tendency as that of nitoflon when the film is used in the downward direction (1) and the evaporation amount is larger than that in the upward direction (2). In this case, since the thickener is not added to the aromatic liquid, the volatilization amount increases almost linearly.

The addition of the thickening agent further ensures the prevention of liquid leakage from the microporous film, and prevents the liquid medicine from splashing around more than necessary when changing the direction of the container. The type and addition amount of the thickener may be appropriately selected and determined depending on the viscosity of the drug solution and the size of the micropores.

As shown in the figure, when the lid is facing downward, the amount of volatilization is the largest, so if you feel that the amount of volatilization is greater than the preferred range, you can change the container sideways or upward, and conversely volatilize upward. When you feel that the amount is small, turn the container sideways or downward. Therefore, the direction is changed cyclically downward, laterally, and upwardly and continuously depending on the direction, and is changed for a fixed period of time, for example, downward 1 hour, lateral 2 hours, upward 3 hours, or by changing in units of a certain period within a preferable range. It can be adjusted to an average volatilization amount. It can also be operated manually or by rotating a motor with a timer.

Although the above description was mainly about the fragrance, the method of the present invention can be applied not only to the fragrance but also to any volatile agents such as deodorants, insect repellents and fungicides.

〔Example〕

A bouquet-type fragrance from Takasago International Co., Ltd. was used as the fragrance, and 10 g of this was injected into a 55φ × 55 (about 130 cc) container and 0.5 g of EHEC was added as a thickener, and mixed to give an fragrance liquid with a viscosity of 300 cp. Obtained. Nitoflon NTF-5200 with a thickness of 80 μm on the lid of the container
I put up.

Prepare four same fragrance containers, one with the lid always facing up, another one facing down, the other two according to the volatilization method of the present invention, one day downward, two days to three days When this is repeated (1) with one cycle being horizontal, upward on the fourth day to the fifth day (1), downward on the first day, horizontal on the second day, third day to the fifth day
In the case of repeating (2) as one cycle with the upward direction on the day, the volatilization amount for 30 days was measured for each container. The results are shown in the table below.

[Effects of the Invention] According to the method for adjusting the amount of volatilization of the present invention, gas is permeated, but volatilization through a membrane that does not permeate a liquid can be adjusted by changing the direction, so that the amount of volatilization in an average preferable range is used. If you want to change the amount of volatilization due to climatic conditions, you can change it manually at any time. Moreover, in this method, a large amount of water and a gelling agent are not required, so that the container can be made small, and in the case of a fragrance, a pure odor can be enjoyed.

[Brief description of drawings]

1 and 2 are graphs showing the relationship between the amount of volatilization and the number of days depending on the orientation of the microporous film, and FIG. 1 shows the case of Nitoflon NTF-5200 as the microporous film.
FIG. 2 shows the case of Evaflex. 1 ... downward, 2 ... upward, 3 ... sideways

Claims (1)

(57) [Claims] 1. A volatile drug solution is contained in a container having a microporous film as a lid, and the container is turned upside down, sideways or downward, and automatically or manually periodically turned. A method for controlling the amount of volatilization of a drug characterized by leaving it alone