JP2025073660A - Blood purification device, control method thereof, and program - Google Patents

Abstract

To provide a blood purification device capable of returning an appropriate amount of blood without a user setting an artery side blood recovery amount and a vein side blood recovery amount in returning blood, and to provide a control method and a program thereof.SOLUTION: A blood purification device includes a blood purifier 100, an artery side blood circuit 130, a vein side blood circuit 140, a vein side blood sensor 240b, a blood pump 131, a control part, and a storage part. The control part drives the blood pump 131 until the vein side blood sensor 240b is brought into a blood non-detection state in returning the blood, and when the vein side blood sensor 240b is brought into a blood non-detection state, drives the blood pump 131 for the capacity of the vein side blood circuit 140 stored in the storage part, and supplies displacement liquid 20 to the vein side blood circuit 140.SELECTED DRAWING: Figure 1

Description

This disclosure relates to a blood purification device, its control method, and program.

For example, JP 2016-047473 A (Patent Document 1) discloses a blood purification device that can perform operations and tasks according to the end of blood return. The blood purification device disclosed in Patent Document 1 is equipped with a blood discrimination means that can detect the presence or absence of blood flowing through the arterial blood circuit or the venous blood circuit, and a recognition means that can recognize the end of blood return, when replacement with replacement fluid is nearing completion, based on the presence or absence of blood detected by the blood discrimination means during blood return.

JP 2016-047473 A

In the blood purification device disclosed in the above-mentioned Patent Document 1, the recognition means can recognize that the replacement with replacement fluid is nearing completion based on the presence or absence of blood detected by the blood discrimination means during blood return. However, the amount of blood collected on the arterial side and the amount of blood collected on the venous side during blood return (blood recovery) depend on the user's settings, and if the user makes an incorrect setting, there is a risk of insufficient blood being returned or replacement fluid entering the patient's body.

The present disclosure aims to solve the above problem by providing a blood purification device, a control method thereof, and a program that can return an appropriate amount of blood without the user having to set the amount of arterial blood collected and the amount of venous blood collected during blood return.

[1] A blood purifier, an arterial blood circuit connected to the blood purifier, a venous blood circuit connected to the blood purifier, a venous blood sensor provided in the venous blood circuit and capable of detecting blood, a blood pump provided in the arterial blood circuit and pumping blood, a control unit that controls at least the blood pump in response to an input from the venous blood sensor, and a memory unit that stores at least the venous circuit capacity on the patient side of the venous blood sensor in the venous blood circuit, and the control unit drives the blood pump until the venous blood sensor detects no blood during blood return, and when the venous blood sensor detects no blood, drives the blood pump by the venous circuit capacity stored in the memory unit to supply replacement fluid to the venous blood circuit.

With the blood purification device configured in this way, the control unit drives the blood pump when blood is returned until the venous blood sensor detects no blood, and when the venous blood sensor detects no blood, the control unit drives the blood pump only for the venous circuit capacity stored in the memory unit to supply replacement fluid to the venous blood circuit, allowing an appropriate amount of blood to be returned. In this case, the blood purification device can prevent overflow and insufficient blood recovery due to user setting errors, and can reduce the burden on the user by eliminating the need for user setting itself.

[2] The blood purification device according to [1] further comprises an arterial blood sensor provided in the arterial blood circuit and capable of detecting blood, the memory unit stores an arterial circuit capacity on the patient side of the arterial blood sensor in the arterial blood circuit, and the control unit drives the blood pump until the arterial blood sensor detects no blood during blood return, and when the arterial blood sensor detects no blood, drives the blood pump by the arterial circuit capacity stored in the memory unit to supply replacement fluid to the arterial blood circuit.

With a blood purification device configured in this way, an appropriate amount of blood can be returned to the arterial blood circuit as well.

[3] The blood purification device according to [1] or [2], wherein the memory unit is capable of storing the venous circuit capacity according to the type of the venous blood circuit.

The blood purification device configured in this way can return an appropriate amount of blood depending on the type of venous blood circuit.

[4] The blood purification device described in [2], wherein the memory unit is capable of storing the arterial circuit capacity according to the type of the arterial blood circuit.

The blood purification device configured in this way can return an appropriate amount of blood depending on the type of arterial blood circuit.

[5] The blood purification device according to any one of [1] to [4], further comprising an input unit capable of inputting at least information on the type of the venous blood circuit, and the control unit identifies the type of the venous blood circuit being used based on the information on the type of the venous blood circuit inputted to the input unit, and reads out the venous circuit capacity of the identified type from the memory unit.

With a blood purification device configured in this way, the user only needs to input information about the type of venous blood circuit, and the appropriate amount of blood can be automatically returned according to the type of venous blood circuit.

[6] The blood purification device described in [4] further includes an input unit capable of inputting at least information on the type of the arterial blood circuit, and the control unit identifies the type of the superior arterial blood circuit being used based on the information on the type of the arterial blood circuit input to the input unit, and reads out the arterial circuit capacity of the identified type from the memory unit.

With a blood purification device configured in this way, the user only needs to input information about the type of arterial blood circuit, and the appropriate amount of blood can be automatically returned according to the type of arterial blood circuit.

[7] A method for controlling a blood purification device comprising a blood purifier, an arterial blood circuit connected to the blood purifier, a venous blood circuit connected to the blood purifier, a venous blood sensor provided in the venous blood circuit capable of detecting blood, a blood pump provided in the arterial blood circuit to pump blood, a control unit that controls at least the blood pump in response to an input from the venous blood sensor, and a memory unit that stores at least the venous circuit capacity on the patient side of the venous blood sensor in the venous blood circuit, the method including the steps of reading out the venous circuit capacity from the memory unit, driving the blood pump until the venous blood sensor detects no blood during blood return, and driving the blood pump by the venous circuit capacity stored in the memory unit to supply replacement fluid to the venous blood circuit when the venous blood sensor detects no blood.

According to this control method for a blood purification device, the blood pump is driven during blood return until the venous blood sensor detects no blood, and when the venous blood sensor detects no blood, the blood pump is driven to supply replacement fluid to the venous blood circuit by the amount of the venous circuit capacity stored in the memory unit, thereby allowing an appropriate amount of blood to be returned.

[8] A program executed by the control unit of a blood purification device including a blood purifier, an arterial blood circuit connected to the blood purifier, a venous blood circuit connected to the blood purifier, a venous blood sensor provided in the venous blood circuit capable of detecting blood, a blood pump provided in the arterial blood circuit to pump blood, a control unit that controls at least the blood pump in response to an input from the venous blood sensor, and a memory unit that stores at least the venous circuit capacity on the patient side of the venous blood sensor in the venous blood circuit, the program including the steps of reading out the venous circuit capacity from the memory unit, driving the blood pump until the venous blood sensor detects no blood during blood return, and driving the blood pump by the venous circuit capacity stored in the memory unit when the venous blood sensor detects no blood to supply replacement fluid to the venous blood circuit.

According to this program, the blood pump is driven during blood return until the venous blood sensor detects no blood, and when the venous blood sensor detects no blood, the blood pump is driven to supply replacement fluid to the venous blood circuit by the amount of the venous circuit capacity stored in the memory unit, allowing an appropriate amount of blood to be returned.

As described above, according to the present disclosure, an appropriate amount of blood can be returned without the user having to set the amount of arterial blood recovered and the amount of venous blood recovered during blood return.

FIG. 1 is a circuit diagram showing a blood purification device. FIG. 2 is a block diagram showing the configuration of the blood purification device related to control during blood return. 13 is a flowchart showing a control flow during blood return. FIG. 13 is a diagram showing an example of control during blood return in the venous blood circuit. FIG. 13 is a diagram showing an example of control for returning blood from a venous blood circuit. FIG. 13 is a diagram showing an example of control during blood return in an arterial blood circuit. FIG. 13 is a diagram showing an example of control for returning blood from an arterial blood circuit. FIG. 11 is a circuit diagram showing a modified example of the blood purification device.

Embodiments of the present disclosure will be described with reference to the drawings. Note that in the drawings referred to below, the same or equivalent components are given the same numbers.

In the following description of the embodiment, a blood purification device used in Continuous Renal Replacement Therapy (CRRT) will be described as a blood purification device. However, the blood purification device may be a blood purification device used in any of Plasma Exchange (PE), Continuous Blood Purification Therapy (CBP), Continuous Hemodiafiltration (CHDF), Continuous Hemofiltration (CHF), Continuous Hemodialysis (CHD), and Slow Continuous UltraFiltration (SCUF), or may be a blood purification device used in general renal replacement therapy.

Figure 1 is a circuit diagram showing a blood purification device. First, the overall configuration of the blood purification device 1 will be explained with reference to Figure 1.

The blood purification device 1 includes a blood purifier 100, a dialysis fluid line 110, a supply pump 111, a drainage line 120, a drainage pump 121, an arterial blood circuit 130, a venous blood circuit 140, a replacement fluid line 150, a replacement fluid pump 151, a first connecting line 160, a first measuring bag 165, a second connecting line 170, a second measuring bag 175, a scale 180, and a syringe pump 190. The type of the blood pump 131 is not particularly limited, but is typically a rotary pump. The supply pump 111, the drainage pump 121, and the replacement fluid pump 151 are not particularly limited, but are typically peristaltic pumps.

The arterial blood circuit 130 and the venous blood circuit 140 are blood flow paths that communicate with the blood purifier 100 and through which blood flows. The dialysate line 110 and the drain line 120 are treatment fluid flow paths that communicate with the blood purifier 100 and through which dialysis fluid flows as a treatment fluid.

The blood purifier 100 includes a semipermeable membrane (blood purification membrane) made of, for example, a hollow fiber membrane. The blood purifier 100 has a dialysate inlet 101, a waste fluid outlet 102, a blood inlet 103, and a blood outlet 104.

The dialysate line 110 is connected to the dialysate inlet 101 of the blood purifier 100 and supplies the dialysate to the blood purifier 100. The upstream end of the dialysate line 110 is connected to a supply source (not shown) that supplies replacement fluid and dialysate. A supply pump 111 (liquid supply pump) that pumps out the dialysate is connected to the dialysate line 110. The dialysate line 110 and the other lines described below are soft tubes made of, for example, polyvinyl chloride or polybutadiene.

The drainage pipeline 120 is connected to the drainage outlet 102 of the blood purifier 100, and allows the drainage discharged from the drainage outlet 102 of the blood purifier 100 to flow. The drainage discharged from the blood purifier 100 is discharged from the downstream end of the drainage pipeline 120. The drainage pipeline 120 is connected to a drainage pump 121 that pumps out the drainage flowing through the drainage pipeline 120. The drainage pipeline 120 is provided with a filtration pressure sensor 122 upstream of the drainage pump 121 to measure the pressure inside the drainage pipeline 120. A secondary membrane pressure sensor 123 is provided downstream of the filtration pressure sensor 122. Furthermore, the drainage pipeline 120 is provided with a blood leakage sensor 2 upstream of the filtration pressure sensor 122.

The arterial blood circuit 130 is connected to the blood inlet 103 of the blood purifier 100, and is a circuit for introducing blood into the blood purifier 100. The arterial blood circuit 130 is provided with a blood pump 131 that pumps out blood. In the arterial blood circuit 130, an arterial air trap chamber 132 is provided between the blood pump 131 and the blood purifier 100. The arterial air trap chamber 132 is provided with an inlet pressure sensor 133 that measures the pressure inside the arterial air trap chamber 132.

Blood collected from the patient's artery via the arterial blood circuit 130 flows through the arterial blood circuit 130, has its pressure measured in the arterial air trap chamber 132, and then flows into the blood purifier 100 from the blood inlet 103. The arterial air trap chamber 132 is provided to prevent air from mixing with the blood in the arterial blood circuit 130.

The arterial blood circuit 130 is provided with an arterial air bubble sensor 230a, an arterial blood sensor 230b, and an arterial clamp 230c. A substitution fluid line 136 branches off from the arterial blood circuit 130, and a substitution fluid clamp 230d is provided on the substitution fluid line 136. The substitution fluid 20 is, for example, physiological saline.

An airless monitor 138 is further connected to the arterial blood circuit 130. Specifically, the airless monitor 138 is connected between the arterial air bubble sensor 230a and the blood pump 131 in the arterial blood circuit 130. A venting blood pressure sensor 139 is connected to the airless monitor 138, and measures the venting blood pressure of the patient flowing into the arterial blood circuit 130.

The venous blood circuit 140 is connected to the blood outlet 104 of the blood purifier 100, and is a circuit for discharging blood from the blood purifier 100 and returning the blood to the patient. The venous blood circuit 140 is provided with a venous air trap chamber 141. The venous air trap chamber 141 is provided with a venous circuit pressure sensor 142 that measures the pressure inside the venous air trap chamber 141.

The blood purified by the blood purifier 100 flows through the venous blood circuit 140, where its pressure is measured in the venous air trap chamber 141, before being returned to the patient. The venous air trap chamber 141 is provided to prevent air from mixing with the blood in the venous blood circuit 140. The venous blood circuit 140 is provided with a venous air bubble sensor 240a, a venous blood sensor 240b, and a venous clamp 240c.

The fluid replacement line 150 is connected to the arterial blood circuit 130 or the venous blood circuit 140 and supplies replacement fluid. In this embodiment, the fluid replacement line 150 is connected to the venous blood circuit 140 and supplies replacement fluid to the venous blood circuit 140. That is, in this embodiment, the blood purification device 1 employs a so-called post-dilution method. Specifically, the fluid replacement line 150 is connected to the venous air trap chamber 141. The replacement fluid that has flowed through the fluid replacement line 150 is supplied into the venous air trap chamber 141. The blood purification device 1 can also be applied to a so-called pre-dilution method. When the pre-dilution method is employed, the fluid replacement line 150 is connected to the arterial blood circuit 130.

A replacement fluid pump 151 that delivers replacement fluid is connected to the replacement fluid line 150. The first connection line 160 is connected to the drainage line 120. Specifically, the first connection line 160 is connected to the drainage line 120 downstream of the drainage pump 121. The first measuring bag 165 is connected to the end of the first connection line 160 opposite the drainage line 120, and is capable of temporarily storing the drainage fluid and delivering the stored drainage fluid. The first measuring bag 165 is a soft bag that does not have any holes for venting air.

The second connection line 170 is connected to the replacement fluid line 150. Specifically, the second connection line 170 is connected to the replacement fluid line 150 upstream of the replacement fluid pump 151. The second measuring bag 175 is connected to the end of the second connection line 170 opposite the replacement fluid line 150, and is capable of temporarily storing replacement fluid and discharging the stored replacement fluid. The second measuring bag 175 is a soft bag that does not have any holes for venting air.

A weight measuring unit is connected to the scale 180. The weight measuring unit measures the overall change in weight of the first weighing bag 165 and the second weighing bag 175 attached to the scale 180. In this embodiment, the scale 180 is a load cell. However, the scale 180 is not limited to a load cell and may be a spring scale or the like.

The syringe pump 190 is connected to the arterial blood circuit 130 via a syringe pump line 191. The syringe pump 190 supplies the medicinal liquid 30 into the arterial blood circuit 130. The medicinal liquid 30 is, for example, an anticoagulant such as heparin or nafamostat.

Next, the control during blood return (blood recovery) when the blood remaining in the blood purification device 1 is returned to the patient after dialysis (blood purification) is completed will be described. FIG. 2 is a block diagram showing the configuration of the blood purification device 1 related to the control during blood return. As shown in FIG. 2, the blood purification device 1 further includes a control unit 90. The control unit 90 receives input from the arterial blood sensor 230b, the venous blood sensor 240b, and the input unit 70, and controls the operation of the blood pump 131, the arterial clamp 230c, the venous clamp 240c, and the replacement fluid clamp 230d. The control unit 90 can further control the operation of the supply pump 111, the drainage pump 121, the replacement fluid pump 151, and the notification unit 80.

The control unit 90 is specifically a control circuit, and has a processor 91 and a memory 92. Specifically, the processor 91 controls the operation of the blood purification device 1 by executing various programs stored in the memory 92.

The processor 91 is composed of a CPU, a GPU, etc., and can read and execute programs (for example, an OS and a control program) stored in the memory 92. The processor 91 executes various programs read from the memory 92. Specifically, the control program controls the return of blood remaining in the blood purification device 1 to the patient when blood is returned.

The memory 92 is composed of, for example, a non-volatile storage device such as a ROM or a flash memory. The memory 92 stores a control program in addition to an OS for implementing basic functions.

The input unit 70 is composed of a keyboard, mouse, microphone, touch device, etc., and can accept information input by the user.

The notification unit 80 is composed of a display, various indicators, alarm lamps, etc., and can notify the user of the status of the blood purification device 1 controlled by the control unit 90, and can issue alarms indicating abnormalities in the control, etc.

The control programs executed by the control unit 90 may be installed via a computer-readable recording medium, or may be installed by downloading them from a server device on a network. In addition, the functions provided by the control unit 90 may be realized by using some of the modules provided by the OS.

Figure 2 shows an example of a configuration in which the functions required for the blood purification device 1 are provided by the processor 91 executing a program, but some or all of these provided functions may be implemented using a dedicated hardware circuit (e.g., ASIC or FPGA). Furthermore, the configuration of the blood purification device 1 shown in Figure 2 is an example and is not limited to this configuration.

In conventional blood purification devices, the user had to set the amount of blood returned from the arterial side and the arterial side (arterial blood recovery amount) and the amount of blood returned from the venous side and the venous side (venous blood recovery amount) during blood return. However, the arterial blood circuit is provided with a blood purifier 100, an arterial air trap chamber 132, etc., making it difficult for the user to accurately set the arterial blood recovery amount. Similarly, the venous blood circuit is provided with a blood purifier 100, a venous air trap chamber 141, etc., making it difficult for the user to accurately set the venous blood recovery amount. If the recovery amount set by the user is greater than the original blood return amount, the replacement fluid will flow into the patient, causing overflow. Conversely, if the recovery amount set by the user is less than the original blood return amount, there will be insufficient blood return and blood will remain in the blood purification device.

The blood purification device 1 according to this embodiment controls the blood to be returned in an appropriate amount without the user having to set the arterial and venous blood recovery amounts. Figure 3 is a flowchart showing the flow of control during blood return. When dialysis (blood purification) is completed, blood remains in the arterial blood circuit 130 and venous blood circuit 140 in the blood purification device 1 as shown in Figure 1 (paths shown by hatching).

First, the control unit 90 reads the venous circuit capacity of the venous blood circuit 140 from the memory 92 (step S101). The venous circuit capacity of the venous blood circuit 140 is stored in advance in the memory 92. Here, the venous circuit capacity is the circuit capacity on the patient side of the venous blood sensor 240b in the venous blood circuit, and is set to, for example, 100 ml. If only one type of venous blood circuit 140 is used, the venous circuit capacity of the venous blood circuit 140 may be stored in the memory 92 as a fixed value. However, if multiple types of venous blood circuits 140 are used, multiple venous circuit capacities are stored in the memory 92 according to the types of venous blood circuits 140.

The control unit 90 identifies the type of venous blood circuit 140 based on the information on the type of venous blood circuit 140 input by the user from the input unit 70, and reads out the venous circuit capacity of the identified type of venous blood circuit 140 from the memory 92. The method of inputting the information on the type of venous blood circuit 140 to the input unit 70 may be a method in which the user directly inputs the model number of the venous blood circuit 140 from a keyboard, or a method in which the identification information (two-dimensional code, IC chip, etc.) attached to the venous blood circuit 140 is read by a reading device. The user may also directly input the venous circuit capacity of the venous blood circuit 140 from a keyboard, etc.

Next, the control unit 90 reads out the arterial circuit capacity of the arterial blood circuit 130 from the memory 92 (step S102). The arterial circuit capacity of the arterial blood circuit 130 is stored in advance in the memory 92. Here, the arterial circuit capacity is the circuit capacity on the patient side of the arterial blood sensor 230b in the arterial blood circuit, and is set to, for example, 100 ml. If only one type of arterial blood circuit 130 is used, the arterial circuit capacity of the arterial blood circuit 130 may be stored in the memory 92 as a fixed value, but if multiple types of arterial blood circuits 130 are used, multiple arterial circuit capacities are stored in the memory 92 according to the types of arterial blood circuits 130.

The control unit 90 identifies the type of the arterial blood circuit 130 based on the information on the type of the arterial blood circuit 130 input by the user from the input unit 70, and reads the arterial circuit capacity of the identified type of arterial blood circuit 130 from the memory 92. The method of inputting the information on the type of the arterial blood circuit 130 to the input unit 70 may be a method in which the user directly inputs the model number of the arterial blood circuit 130 from a keyboard, or a method in which the identification information (two-dimensional code, IC chip, etc.) attached to the arterial blood circuit 130 is read by a reading device. The user may also directly input the arterial circuit capacity of the arterial blood circuit 130 from a keyboard, etc.

Next, the control unit 90 drives the blood pump 131 in the forward direction to supply the replacement fluid 20 from the arterial blood circuit 130 to the venous blood circuit 140 (step S103). When supplying the replacement fluid 20 from the arterial blood circuit 130 to the venous blood circuit 140, the control unit 90 controls the venous clamp 240c and the replacement fluid clamp 230d to be in an open state. By supplying the replacement fluid 20 from the arterial blood circuit 130 to the venous blood circuit 140, the blood remaining in the blood purification device 1 is returned from the venous blood circuit 140 to the patient as shown in FIG. 4. FIG. 4 is a diagram showing an example of control during blood return in the venous blood circuit 140. Note that blood remains in the path indicated by hatching in FIG. 4.

Returning to FIG. 3, the control unit 90 determines whether the venous blood sensor 240b has detected a state in which blood is not detected (step S104). If the venous blood sensor 240b has not detected a state in which blood is not detected (NO in step S104), the control unit 90 returns the process to step S103 and continues to supply the substitution fluid 20 from the arterial blood circuit 130 to the venous blood circuit 140. In other words, the substitution fluid 20 has not yet reached the position of the venous blood sensor 240b, and blood still remains in the venous blood circuit 140.

On the other hand, when the venous blood sensor 240b detects a state where blood is not detected (YES in step S104), the control unit 90 supplies the replacement fluid 20 to the venous blood circuit 140 by the venous circuit capacity of the venous blood circuit 140 read from the memory 92 (step S105). When the venous blood sensor 240b detects a state where blood is not detected, as shown in FIG. 4, blood is returned from the venous blood circuit 140, but blood still remains in the venous blood circuit 140. Therefore, if the control unit 90 supplies the replacement fluid 20 to the venous blood circuit 140 by the venous circuit capacity, the blood in the venous blood circuit 140 can be returned to the patient without excess or deficiency as shown in FIG. 5. FIG. 5 is a diagram showing an example of control for returning blood from the venous blood circuit 140. Note that blood remains in the path indicated by hatching in FIG. 5. Specifically, when the venous circuit capacity is 100 ml, the control unit 90 drives the blood pump 131 in the forward direction so that 100 ml of replacement fluid 20 is supplied to the venous blood circuit 140. In addition, when the venous blood sensor 240b detects a state in which blood is not detected, the control unit 90 may control the notification unit 80 to notify the user that the blood return in the venous blood circuit 140 will end with 100 ml remaining.

Next, the blood in the arterial blood circuit 130 is returned to the patient. Returning to FIG. 3, the control unit 90 drives the blood pump 131 in reverse rotation to supply the substitution fluid 20 to the arterial blood circuit 130 (step S106). When supplying the substitution fluid 20 to the arterial blood circuit 130, the control unit 90 controls the venous clamp 240c to be in a closed state and the arterial clamp 230c and the substitution fluid clamp 230d to be in an open state. When the blood in the venous blood circuit 140 is returned to the patient, there is no blood remaining on the venous blood circuit 140 side from the position of the arterial blood circuit 130 branched off from the substitution fluid line 136 as shown in FIG. 5. Therefore, the blood pump 131 is driven in reverse rotation to return the blood on the arterial blood circuit 130 side from the position of the arterial blood circuit 130 branched off from the substitution fluid line 136 to the patient.

Next, the control unit 90 determines whether the arterial blood sensor 230b has detected a state in which blood is not detected (step S107). If the arterial blood sensor 230b has not detected a state in which blood is not detected (NO in step S107), the control unit 90 returns the process to step S106 and continues to supply the substitution fluid 20 to the arterial blood circuit 130. In other words, the substitution fluid 20 has not reached the position of the arterial blood sensor 230b, and blood still remains in the arterial blood circuit 130.

On the other hand, if the arterial blood sensor 230b detects a state in which blood is not detected (YES in step S107), the control unit 90 supplies the substitution fluid 20 to the arterial blood circuit 130 by the arterial circuit capacity read from the memory 92 (step S108). When the arterial blood sensor 230b detects a state in which blood is not detected, blood still remains in the arterial blood circuit 130 as shown in FIG. 6. FIG. 6 is a diagram showing an example of control during blood return in the arterial blood circuit 130. Note that blood remains in the paths indicated by hatching in FIG. 6.

Therefore, if the control unit 90 supplies the substitution fluid 20 to the arterial blood circuit 130 in an amount equal to the arterial circuit capacity, the blood in the arterial blood circuit 130 can be returned to the patient without excess or deficiency as shown in FIG. 7. FIG. 7 is a diagram showing an example of control for returning blood from the arterial blood circuit 130. Specifically, when the arterial circuit capacity is 100 ml, the control unit 90 drives the blood pump 131 in reverse rotation so that 100 ml of substitution fluid 20 is supplied to the arterial blood circuit 130. In addition, when the arterial blood sensor 230b detects a state in which blood is not detected, the control unit 90 may control the notification unit 80 to notify that the blood return in the arterial blood circuit 130 will end with 100 ml remaining.

To supply the replacement fluid 20 to the patient from the branched portion of the replacement fluid line 136 in the arterial blood circuit 130 by driving the blood pump 131 in the reverse direction, for example, the blood pump 131 is once driven in the forward direction to store the replacement fluid 20 in the arterial air trap chamber 132, and then the blood pump 131 is driven in the reverse direction. The supply of the replacement fluid 20 to the arterial blood circuit 130 and the venous blood circuit 140 depends on the device configuration of the blood purification device 1, and is not limited to the above control. In either control, the blood purification device 1 supplies the replacement fluid 20 to the venous blood circuit 140 by the arterial circuit capacity when the venous blood sensor 240b detects a blood undetected state, and supplies the replacement fluid 20 to the arterial blood circuit 130 by the arterial circuit capacity when the arterial blood sensor 230b detects a blood undetected state.

According to the blood purification device 1 configured in this manner, when the venous blood sensor 240b is in a state where blood is not detected, the control unit 90 drives the blood pump 131 to supply the replacement fluid 20 to the venous blood circuit 140 by the arterial circuit capacity stored in the memory 92, so that an appropriate amount of blood can be returned to the venous blood circuit 140. Furthermore, when the arterial blood sensor 230b is in a state where blood is not detected, the blood purification device 1 drives the blood pump 131 to supply the replacement fluid 20 to the arterial blood circuit 130 by the arterial circuit capacity stored in the memory 92, so that an appropriate amount of blood can be returned. In addition, in this case, the blood purification device 1 can prevent overflow and insufficient blood recovery due to user setting errors, and can reduce the burden on the user by eliminating the need for user setting itself.

(Modification)
In the blood purification device 1 shown in Fig. 1, the arterial blood sensor 230b and the venous blood sensor 240b are provided, and the amount of replacement fluid 20 supplied to the arterial blood circuit 130 and the venous blood circuit 140 is controlled. However, if the user visually controls the amount of replacement fluid to be supplied to return blood remaining in the arterial blood circuit 130 or controls the amount of replacement fluid by another method, the blood purification device does not need to be provided with an arterial blood sensor. Fig. 8 is a circuit diagram showing a modified example of the blood purification device 1a. In the blood purification device 1a shown in Fig. 8, the same components as those shown in the blood purification device 1 shown in Fig. 1 are denoted by the same reference numerals and detailed description will not be repeated.

The blood purification device 1a has a blood purifier 100, a dialysis fluid line 110, a fluid supply pump 111, a drainage line 120, a drainage pump 121, an arterial blood circuit 130, a venous blood circuit 140, a fluid replacement line 150, a fluid replacement pump 151, a first connecting line 160, a first measuring bag 165, a second connecting line 170, a second measuring bag 175, a scale 180, and a syringe pump 190.

The arterial blood circuit 130 is provided with an arterial bubble sensor 230a and an arterial clamp 230c. A substitution fluid line 136 branches off from the arterial blood circuit 130, and a substitution fluid clamp 230d is provided on the substitution fluid line 136. The arterial blood circuit 130 is not provided with an arterial blood sensor for determining whether blood remains in the arterial blood circuit 130.

Therefore, when the venous blood sensor 240b detects a blood undetected state, the blood purification device 1a supplies replacement fluid 20 to the venous blood circuit 140 in an amount equal to the venous circuit capacity, and is able to return an appropriate amount of blood to the venous blood circuit 140. On the other hand, when returning blood remaining in the arterial blood circuit 130, the blood purification device 1a controls the amount of replacement fluid 20 supplied by the user through visual inspection, or controls the amount of replacement fluid 20 by another method. Since the blood purification device 1a does not need to have an arterial blood sensor, the device configuration can be simplified and manufacturing costs can be reduced.

The embodiments disclosed herein should be considered to be illustrative and not restrictive in all respects. The scope of the present invention is indicated by the claims, not by the above description, and is intended to include all modifications within the meaning and scope of the claims.

1, 1a blood purification device, 2 blood leakage sensor, 20 substitution fluid, 30 drug solution, 70 input unit, 80 notification unit, 90 control unit, 91 processor, 92 memory, 100 blood purifier, 101 dialysis fluid inlet, 102 drainage outlet, 103 blood inlet, 104 blood outlet, 110 dialysis fluid line, 111 supply pump, 120 drainage line, 121 drainage pump, 122 filtration pressure sensor, 130 arterial blood circuit, 131 blood pump, 132 arterial air trap chamber, 133 inlet pressure sensor, 136 substitution fluid line, 138 airless monitor, 139 venting pressure sensor, 140 venous blood circuit, 141 venous air trap chamber, 142 venous circuit pressure sensor, 150 replacement fluid line, 151 replacement fluid pump, 160 First connecting line, 165 first weighing bag, 170 second connecting line, 175 second weighing bag, 180 scale, 190 syringe pump, 191 syringe pump line.

Claims (8)

Blood purifier,
an arterial blood circuit connected to the blood purifier;
a venous blood circuit connected to the blood purifier;
a venous blood sensor provided in the venous blood circuit and capable of detecting blood;
a blood pump provided in the arterial blood circuit for pumping blood;
a control unit that controls at least the blood pump in response to an input from the venous blood sensor;
a memory unit that stores at least a venous circuit capacitance on a patient side of the venous blood sensor in the venous blood circuit,
The control unit is
A blood purification device that drives the blood pump until the venous blood sensor detects no blood during blood return, and when the venous blood sensor detects no blood, drives the blood pump by an amount corresponding to the venous circuit capacity stored in the memory unit to supply replacement fluid to the venous blood circuit. An arterial blood sensor is provided in the arterial blood circuit and is capable of detecting blood.
the storage unit stores an arterial circuit capacitance on a patient side of the arterial blood circuit relative to the arterial blood sensor;
The control unit is
2. The blood purification device according to claim 1, wherein the blood pump is driven until the arterial blood sensor detects no blood during blood return, and when the arterial blood sensor detects no blood, the blood pump is driven by an amount corresponding to the arterial circuit capacity stored in the memory unit to supply substitution fluid to the arterial blood circuit. The blood purification device according to claim 1, wherein the memory unit is capable of storing the venous circuit capacity according to the type of the venous blood circuit. The blood purification device according to claim 2, wherein the memory unit is capable of storing the arterial circuit capacity according to the type of the arterial blood circuit. an input unit capable of inputting at least information on the type of the venous blood circuit;
The control unit is
4. The blood purification apparatus according to claim 3, wherein the type of the venous blood circuit being used is identified based on information on the type of the venous blood circuit inputted to the input unit, and the venous circuit capacity of the identified type is read out from the storage unit. An input unit capable of inputting at least information on the type of the arterial blood circuit,
The control unit is
5. The blood purification apparatus according to claim 4, wherein the type of the arterial blood circuit being used is identified based on information on the type of the arterial blood circuit inputted to the input unit, and the arterial blood circuit capacity of the identified type is read out from the storage unit. A control method for a blood purification device comprising: a blood purifier; an arterial blood circuit connected to the blood purifier; a venous blood circuit connected to the blood purifier; a venous blood sensor provided in the venous blood circuit and capable of detecting blood; a blood pump provided in the arterial blood circuit and pumping blood; a control unit that controls at least the blood pump in response to an input from the venous blood sensor; and a memory unit that stores at least a venous circuit capacity on a patient's side of the venous blood sensor in the venous blood circuit,
reading out the venous circuit capacitance from the storage unit;
driving the blood pump until the venous blood sensor detects no blood during blood return;
A method for controlling a blood purification apparatus comprising the step of driving the blood pump by an amount corresponding to the venous circuit capacity stored in the memory unit when the venous blood sensor is in a state where blood is not being detected, to supply replacement fluid to the venous blood circuit. A program executed by a control unit of a blood purification device comprising: a blood purifier; an arterial blood circuit connected to the blood purifier; a venous blood circuit connected to the blood purifier; a venous blood sensor provided in the venous blood circuit and capable of detecting blood; a blood pump provided in the arterial blood circuit and pumping blood; a control unit that controls at least the blood pump in response to an input from the venous blood sensor; and a memory unit that stores at least a venous circuit capacity on a patient's side of the venous blood sensor in the venous blood circuit,
The program is
reading out the venous circuit capacitance from the storage unit;
driving the blood pump until the venous blood sensor detects no blood during blood return;
When the venous blood sensor is in a state of not detecting blood, the program includes a step of driving the blood pump by an amount corresponding to the venous circuit capacity stored in the memory unit to supply replacement fluid to the venous blood circuit.

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