JP2022124792A - Method for producing bioabsorbable floc - Google Patents
Method for producing bioabsorbable floc Download PDFInfo
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- JP2022124792A JP2022124792A JP2021022640A JP2021022640A JP2022124792A JP 2022124792 A JP2022124792 A JP 2022124792A JP 2021022640 A JP2021022640 A JP 2021022640A JP 2021022640 A JP2021022640 A JP 2021022640A JP 2022124792 A JP2022124792 A JP 2022124792A
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- polyglycolide
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- 239000000463 material Substances 0.000 claims description 34
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Polymers OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 13
- 229920000954 Polyglycolide Polymers 0.000 claims description 13
- 238000004519 manufacturing process Methods 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 7
- 238000002074 melt spinning Methods 0.000 claims description 5
- 238000010438 heat treatment Methods 0.000 claims description 4
- 229920000742 Cotton Polymers 0.000 description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 238000010521 absorption reaction Methods 0.000 description 7
- 238000005259 measurement Methods 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 4
- 230000006835 compression Effects 0.000 description 4
- 238000007906 compression Methods 0.000 description 4
- 239000000835 fiber Substances 0.000 description 4
- 230000000704 physical effect Effects 0.000 description 4
- 229920000728 polyester Polymers 0.000 description 4
- 238000011084 recovery Methods 0.000 description 4
- 210000001124 body fluid Anatomy 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 2
- 239000004745 nonwoven fabric Substances 0.000 description 2
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229940127554 medical product Drugs 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
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- Nonwoven Fabrics (AREA)
Abstract
Description
本発明は、吸水性の高い生体吸収性綿状体を得ることができる生体吸収性綿状体の製造方法に関する。 TECHNICAL FIELD The present invention relates to a method for producing a bioabsorbable cotton-like material that can obtain a bioabsorbable cotton-like material having high water absorption.
医療の分野では、手術用具の材料として生体吸収性材料が用いられることがある。生体吸収性材料を用いることで、役割を果たした後は体内へ吸収され消滅することから、再度取り出しのための再手術を行う必要がなく、安全性を高めることができる。具体的には、体液漏れ、空気漏れを防止する基材として、例えば、特許文献１に開示されるような生体吸収性材料からなる不織布が用いられている。 In the medical field, bioabsorbable materials are sometimes used as materials for surgical instruments. By using a bioabsorbable material, it is absorbed into the body and disappears after it has fulfilled its role, so there is no need to perform a second operation for removal, and safety can be improved. Specifically, a nonwoven fabric made of a bioabsorbable material as disclosed in Patent Literature 1, for example, is used as a base material for preventing leakage of bodily fluids and air.
一方、医療の分野では綿が多様な用途で日常的に用いられている。例えば、外科手術においては、体液を吸収させる目的に綿が用いられている。このような外科手術で用いられる綿は、取り出し忘れのミスが起こり得るため、取り出し忘れてしまった際の安全性を確保するために、生体吸収性材料からなる綿への需要が高まっている。しかしながら、従来の生体吸収性材料を用いた医療用品は平面の不織布や固形状がほとんどであり、綿状とすることが難しいという問題があった。また、従来の生体吸収性材料からなる医療用品は吸水性が低いという問題もあり、吸水性の高い生体吸収性の綿状体を得ることはより困難であった。 On the other hand, in the medical field, cotton is routinely used for various purposes. For example, cotton is used in surgical procedures to absorb body fluids. Since cotton used in such surgical operations can be mistakenly forgotten to be taken out, there is an increasing demand for cotton made of a bioabsorbable material in order to ensure safety when the cotton is forgotten to be taken out. However, most of conventional medical products using bioabsorbable materials are flat non-woven fabrics or in solid form, and there is a problem that it is difficult to make cotton-like products. In addition, there is also the problem that medical supplies made of conventional bioabsorbable materials have low water absorption, and it has been more difficult to obtain a bioabsorbable cotton-like body with high water absorption.
本発明は、上記問題に鑑み、吸水性の高い生体吸収性綿状体を得ることができる生体吸収性綿状体の製造方法を提供することを目的とする。 SUMMARY OF THE INVENTION In view of the above problems, an object of the present invention is to provide a method for producing a bioabsorbable cotton-like material that can obtain a bioabsorbable cotton-like material with high water absorption.
本発明は、医療用に用いられる生体吸収性綿状体の製造方法であって、ポリグリコリドを溶融紡糸によって糸にする工程と、前記糸にウーリー加工を施す工程とを有する生体吸収性綿状体の製造方法である。
以下、本発明について詳説する。
The present invention is a method for producing a bioabsorbable cotton-like material for medical use, comprising the steps of forming a yarn by melt-spinning polyglycolide and applying a wooly process to the yarn. It is the manufacturing method of the body.
The present invention will be described in detail below.
本発明者らは鋭意検討した結果、ポリグリコリドからなる糸にウーリー加工を施すことで、生体吸収性材料を綿状とできることを見出し、本発明を完成させるに至った。 As a result of intensive studies, the present inventors have found that a bioabsorbable material can be made into a cotton-like material by applying a woolly process to a thread made of polyglycolide, and have completed the present invention.
本発明の生体吸収性綿状体の製造方法は、まず、ポリグリコリドを溶融紡糸によって糸にする工程を行う。
ポリグリコリドを材料に用いることで、得られる綿状体に生体吸収性を付与することができる。また、ポリグリコリドは比較的分解速度が速いことから、より短期間で体内に吸収させることができる。更に、ポリグリコリドを用いることで、より綿に近い物性とすることができる。なおここで、綿状体とは、繊維が絡まりあって密度の低い軽量の塊の状態になっているものを指す。
In the method for producing the bioabsorbable cotton-like material of the present invention, first, a step of forming polyglycolide into yarn by melt spinning is carried out.
By using polyglycolide as a material, bioabsorbability can be imparted to the obtained cotton-like body. Also, since polyglycolide decomposes at a relatively high rate, it can be absorbed into the body in a shorter period of time. Furthermore, by using polyglycolide, physical properties closer to those of cotton can be obtained. Here, the cotton-like body refers to a state in which fibers are tangled together to form a low-density, lightweight lump.
上記糸の太さは特に限定されないが、１．０μｍ以上３０μｍ以下であることが好ましい。
上記糸の太さが上記範囲であることで、得られる綿状体の取り扱い性を向上させることができるとともに、物性をより綿に近づけることができる。上記糸の太さは５μｍ以上であることがより好ましく、２０μｍ以下であることがより好ましい。
Although the thickness of the thread is not particularly limited, it is preferably 1.0 μm or more and 30 μm or less.
When the thickness of the yarn is within the above range, the handleability of the obtained cotton-like material can be improved, and the physical properties can be made closer to those of cotton. The thickness of the thread is more preferably 5 μm or more, and more preferably 20 μm or less.
上記溶融紡糸の方法については特に限定されず従来公知の方法や条件を特に限定なく用いることができる。 The melt spinning method is not particularly limited, and conventionally known methods and conditions can be used without particular limitations.
上記ポリグリコリドの重量平均分子量は特に限定されないが、３００００以上２０００００以下であることが好ましい。
ポリグリコリドの重量平均分子量が３００００以上であることで、得られる生体吸収性綿状体の強度をより高めることができ、２０００００以下であることで、分解速度をより高めることができる。上記ポリグリコリドの重量平均分子量は、５００００以上であることがより好ましく、１５００００以下であることがより好ましい。
Although the weight average molecular weight of the polyglycolide is not particularly limited, it is preferably 30,000 or more and 200,000 or less.
When the weight average molecular weight of the polyglycolide is 30,000 or more, the strength of the obtained bioabsorbable cotton-like material can be further increased, and when it is 200,000 or less, the decomposition rate can be further increased. The weight average molecular weight of the polyglycolide is more preferably 50,000 or more, and more preferably 150,000 or less.
本発明の生体吸収性綿状体の製造方法は、次いで、上記糸にウーリー加工を施す工程を行う。
ウーリー加工とは、繊維に撚りをかけて加熱し、その後撚りを戻す加工のことを指す。ウーリー加工を施すと繊維が捲縮して嵩高くなるため、ポリグリコリドからなる糸にウーリー加工を施し、まとめることで、形状を綿状とすることができる。
Next, in the method for producing a bioabsorbable cotton-like material of the present invention, the yarn is woolly processed.
Woolly processing refers to processing in which fibers are twisted, heated, and then untwisted. When woolly processing is applied, the fibers are crimped and bulky. Therefore, by applying woolly processing to polyglycolide yarns and bundling them together, they can be made into a cotton-like shape.
上記ウーリー加工における加熱温度は、５０℃以上２００℃以下であることが好ましい。
上記範囲の加熱温度とすることで、糸を充分に捲縮させることができ、得られる綿状体の物性をより綿に近づけることができる。上記加熱温度は７０℃以上であることがより好ましく、１５０℃以下であることがより好ましい。
The heating temperature in the woolly processing is preferably 50° C. or higher and 200° C. or lower.
By setting the heating temperature within the above range, the yarn can be sufficiently crimped, and the physical properties of the resulting cotton-like material can be made closer to those of cotton. The heating temperature is more preferably 70° C. or higher, and more preferably 150° C. or lower.
本発明の生体吸収性綿状体の製造方法によって得られる生体吸収性綿状体は、医療の分野に用いられる。本発明によって得られる生体吸収性綿状体は、吸水性に優れることから例えば、外科手術において患部周辺に詰めて体液を吸わせるような用途で大きな効果を発揮する。本発明によって得られる生体吸収性綿状体は生体吸収性であるため、たとえ体内へ残留してしまったとしても、最終的に体内へ吸収されて消滅するため安全性が高い。 The bioabsorbable cotton-like material obtained by the method for producing the bioabsorbable cotton-like material of the present invention is used in the medical field. Since the bioabsorbable cotton-like body obtained by the present invention is excellent in water absorbability, it exhibits a great effect in applications such as stuffing around an affected area in a surgical operation to absorb body fluids. Since the bioabsorbable cotton-like material obtained by the present invention is bioabsorbable, even if it remains in the body, it is finally absorbed into the body and disappears, so it is highly safe.
本発明によれば、吸水性の高い生体吸収性綿状体を得ることができる生体吸収性綿状体の製造方法を提供することができる。 ADVANTAGE OF THE INVENTION According to this invention, the manufacturing method of the bioabsorbable cotton-like material which can obtain the bioabsorbable cotton-like material with high water absorption can be provided.
以下に本発明の態様を更に詳しく説明するが、本発明はこれらの態様にのみ限定されるものではない。 Embodiments of the present invention will be described in more detail below, but the present invention is not limited only to these embodiments.
（実施例１）
溶融紡糸法により、重量平均分子量２０００００のポリグリコリドからなる糸を得た。次いで、得られたポリグリコリドにフリクション式試験機を用いて、撚り数２０００Ｔ／ｍ、セット温度１４０℃の条件でウーリー加工を行い、一定間隔で切断後まとめることで生体吸収性綿状体を得た。
(Example 1)
A yarn of polyglycolide having a weight average molecular weight of 200,000 was obtained by melt spinning. Next, using a friction type tester, the obtained polyglycolide is subjected to woolly processing under the conditions of a twist number of 2000 T/m and a set temperature of 140° C., cut at regular intervals, and then bundled to obtain a bioabsorbable cotton-like material. rice field.
（比較例１）
ウーリー加工を行わなかった以外は実施例１と同様の方法で生体吸収性綿状体を得た。
(Comparative example 1)
A bioabsorbable cotton-like material was obtained in the same manner as in Example 1, except that the wooly processing was not performed.
（参考例１）
ポリエステル綿（ポリエステルコットン１００％、清原株式会社製 手芸わた（ＳＷ－３００））をそのまま用いた。
(Reference example 1)
Polyester cotton (100% polyester cotton, handicraft cotton (SW-300) manufactured by Kiyohara Co., Ltd.) was used as it was.
（参考例２）
綿（オーガニックコットン１００％）をそのまま用いた。
(Reference example 2)
Cotton (100% organic cotton) was used as it was.
＜物性＞
実施例で得られた生体吸収性綿状体及び参考例の綿について以下の測定を行った。結果を表１に示した。
<Physical properties>
The bioabsorbable cotton-like material obtained in Examples and the cotton of Reference Example were subjected to the following measurements. Table 1 shows the results.
（比容積の測定）
ＪＩＳ Ｌ １０９７に準拠した方法で生体吸収性綿状体及び綿の比容積、圧縮率及び回復率を測定した。結果を表１に示した。
具体的には、まず、得られた生体吸収性綿状体又は綿を２０×２０ｃｍのサンプルとし、質量が約４０ｇとなるまで積み重ねて試験片を得た。次いで、得られた試験片を１時間放置し、秤量した。次いで、試験片に１４ｇの厚板を載せ、更に６３ｇの重りＡを３０秒間載せ、その後重りＡを取り除いて３０秒間放置した。この操作を３回繰り返し、３回目終了後の試験片の４すみの高さを測定して平均値を求めた。得られた４すみの高さの平均値を基に下記式から比容積を算出した。なお、試験は３個の試験片について行い、３個の測定値の平均で表した。
比容積（ｃｍ３／ｇ）＝（５×５×（ｈ０／１０））／Ｗ
ｈ０：重りＡ除去後の試験片の４すみの高さの平均値（ｍｍ）
Ｗ：試験片の質量（ｇ）
(Measurement of specific volume)
The specific volume, compression rate and recovery rate of the bioabsorbable cotton-like body and cotton were measured by a method based on JIS L 1097. Table 1 shows the results.
Specifically, first, the obtained bioabsorbable cotton-like material or cotton was used as a sample of 20×20 cm, and the samples were stacked until the mass reached about 40 g to obtain a test piece. The resulting test piece was then left for 1 hour and weighed. Next, a 14 g thick plate was placed on the test piece, and a 63 g weight A was placed thereon for 30 seconds, after which the weight A was removed and left for 30 seconds. This operation was repeated 3 times, and the heights of the four corners of the test piece were measured after the 3rd time, and the average value was obtained. Based on the obtained average height of the four corners, the specific volume was calculated from the following formula. The test was performed on three test pieces, and the average of the three measured values was shown.
Specific volume (cm3/g) = (5 x 5 x (h0/10))/W
h0: Average height of four corners of test piece after weight A is removed (mm)
W: Mass of test piece (g)
（圧縮率、回復率の測定）
上記比容積の測定と同様の方法で試験片の４すみの高さを測定した後、１２６ｇの重りＢを３０秒載せ、試験片の４すみの高さを測定した。次いで、重りＢを取り除いて３分後の試験片の４すみの高さを測定した。測定した４すみの高さをそれぞれ平均し、得られた３つの平均値を用いて下記式より圧縮率及び回復率を算出した。なお、試験は３個の試験片について行い、３個の測定値の平均で表した。
圧縮率（％）＝（ｈ０－ｈ１）／ｈ０＊１００
回復率（％）＝（ｈ２－ｈ１）／（ｈ０－ｈ１）＊１００
ｈ１：重りＢを載せたときの試験片の４すみの高さの平均値（ｍｍ）
ｈ２：重りＢ除去後の試験片の４すみの高さの平均値（ｍｍ）
(Measurement of compression rate and recovery rate)
After measuring the height of the four corners of the test piece in the same manner as in the measurement of the specific volume, a weight B of 126 g was placed on the test piece for 30 seconds, and the height of the four corners of the test piece was measured. Next, the weight B was removed and the height of the four corners of the test piece was measured 3 minutes later. The measured heights of the four corners were averaged, and the three average values obtained were used to calculate the compression rate and recovery rate from the following equations. The test was performed on three test pieces, and the average of the three measured values was shown.
Compression ratio (%) = (h0-h1)/h0*100
Recovery rate (%) = (h2-h1) / (h0-h1) * 100
h1: Average height of four corners of test piece when weight B is placed (mm)
h2: Average height of four corners of test piece after weight B is removed (mm)
（保水率の測定）
ＪＩＳ Ｌ １９１２－１９９７に準拠した方法で生体吸収性綿状体及び綿の保水率を測定し、吸水性を評価した。
具体的には、まず、標準状態のサンプルの初期重量を測定し、水を入れた容器に１８０秒間水面下に入れた。その後、水中からサンプルを取り出し、１２０秒間垂直に吊るし、試験後重量を測定した。得られた重量を基に、下記式より保水率を算出した。結果を表１に示した。なお、参考例２については脱脂されていなかったため、測定を行わなかった。
ＷＡ＝（ＭＮ－ＭＫ）／ＭＫ×１００
ＷＡ：保水率（％）
ＭＫ：初期重量（ｇ）（５回平均値）
ＭＮ：試験後重量（ｇ）（５回平均値）
(Measurement of water retention rate)
The water retention rate of the bioabsorbable cotton-like body and cotton was measured by a method based on JIS L 1912-1997 to evaluate the water absorption.
Specifically, first, the initial weight of a sample under standard conditions was measured, and the sample was submerged in a container containing water for 180 seconds. The samples were then removed from the water, hung vertically for 120 seconds, and weighed after the test. Based on the obtained weight, the water retention rate was calculated from the following formula. Table 1 shows the results. In addition, since Reference Example 2 was not degreased, no measurement was performed.
W A = (M N −M K )/M K ×100
WA : Water retention rate (%)
M K : initial weight (g) (average value of 5 times)
M N : weight after test (g) (average of 5 times)
表１より実施例の生体吸収性綿状体が綿と似た性能を有しており、綿の代わりとして用いることができることが分かる。また、実施例１、比較例１の生体吸収性綿状体と、参考例１のポリエステル綿と、参考例２のオーガニックコットンとを比較した写真を図１に示した。図１を見ればわかるように、実施例１の方が比較例１よりも繊維の絡み合いが緻密でより綿に近いことが分かる。 From Table 1, it can be seen that the bioabsorbable cotton-like bodies of Examples have performance similar to that of cotton and can be used as a substitute for cotton. In addition, photographs comparing the bioabsorbable cotton-like bodies of Example 1 and Comparative Example 1, the polyester cotton of Reference Example 1, and the organic cotton of Reference Example 2 are shown in FIG. As can be seen from FIG. 1, Example 1 has denser entanglement of fibers than Comparative Example 1 and is closer to cotton.
本発明によれば、吸水性の高い生体吸収性綿状体を得ることができる生体吸収性綿状体の製造方法を提供することができる。 ADVANTAGE OF THE INVENTION According to this invention, the manufacturing method of the bioabsorbable cotton-like material which can obtain the bioabsorbable cotton-like material with high water absorption can be provided.
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