JP2021168897A - Scar keloid treatment tool - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a keloid treatment tool which is made of an inexpensive material and has a small load on a patient in the treatment of keloid which has an ugly appearance, is accompanied by pain and itch, and is difficult to improve the symptom.
SOLUTION: A keroid treatment tool is composed of a stretch sheet made of a crystalline polymer resin having airtightness, flexibility and elasticity, and a gel having a moisturizing effect, and the stretch sheet is made of polyvinylidene chloride or a multilayer. Use polyolefins to have a moisturizing effect but contain purified water of gel, glycerin, carbomer, sodium polyacrysate, methylparaben and propylparaben.
[Selection diagram] FIG. 11

Description

The present invention relates to a therapeutic tool for treating scars and keloids (hereinafter referred to as scar keloids) in which collagen fibers have proliferated, which are formed on trauma, surgical wounds, scars of insect bites and acne.

Scar keloid is a tumor-like growth of collagenous scar caused by trauma, surgery, insect bites, acne, etc., and fibrosis is terminated by persistent inflammation of unknown cause in the process of healing the wound. It is believed to be a skin fibroproliferative disorder caused by not doing so. Once scarred and keloid, it is difficult for the skin to return to its original state on its own. Not only is the appearance ugly, but itching and pain are felt due to the generation of inflammatory cells in the lesion, and some of them spread to the surrounding healthy areas, so if left untreated, the quality of life (QOL) ) Will decrease. However, since the cause of scar keloids has not been elucidated, treatment must rely on symptomatic treatment, and administration and application of drugs do not provide sufficient effects, such as individual differences in effects. In many cases.

Skin tension has an adverse effect on the onset of scar keloids because the chest and shoulders, where skin tension is strong, are the most common sites for scar keloids, and scar keloids extend in the direction of skin tension. Therefore, treatment using elastic tape or silicon sheet is performed mainly for the purpose of weakening the tension of the skin, and it consists of, for example, an organic silicon compound and a cosmetically active substance. Moreover, a product (Patent Document 1) is known in which the compound and the substance are bound to a molecule made of a material that fixes them in the skin.

However, since the silicon sheet is expensive, if it is discarded each time it is peeled off in order to wash the area around the affected area, the cost burden will be high. There was also the problem that it would come off and be lost without the person's knowledge.

Japanese Unexamined Patent Publication No. 63-277609

The present invention has been made in view of such circumstances, and an object of the present invention is to provide a scar keloid treatment tool which is made of an inexpensive material and has a small load on a patient in the treatment of scar keloid.

In order to meet such an object, the scar keloid treatment tool according to the present invention includes a stretch sheet made of a crystalline polymer resin having airtightness, flexibility and elasticity.
A gel with a moisturizing effect and
It is characterized by being composed of.

According to such a configuration, the air that activates a cytokine called TGF-β1 involved in the mechanism involved in keloid development and the mechanism that inhibits keloid apoptosis is blocked, and the activity of TGF-β1 due to drying of the affected area is blocked. It can also be prevented from becoming keloid.

Further, in order to meet such an object, the stretch sheet made of a crystalline polymer resin of the therapeutic tool according to the present invention is characterized by being made of polyvinylidene chloride.

According to such a configuration, the stretch sheet has a small gap between molecules, has excellent barrier properties, makes it difficult for odor, moisture (moisture), and oxygen to pass through, and has a large force acting between molecules, so that it has high adhesion. It also has excellent heat resistance, permeability, and tensile elasticity.

Further, in order to meet such an object, the stretch sheet made of a crystalline polymer resin of the therapeutic tool according to the present invention is made of multilayer polyolefin.

According to such a configuration, a sheet made of polyethylene or the like, which is inexpensive but easily allows oxygen to pass through in a single layer, has a multi-layer structure, so that higher barrier properties and adhesiveness can be obtained as compared with the single layer.

In order to meet such an object, the stretch sheet made of a crystalline polymer resin of the therapeutic tool according to the present invention is characterized in that an amorphous polymer of polyalkyl methacrylates is blended.

According to such a configuration, the stretch sheet can have a shape memory, and the fit with the skin can be improved.

Moreover, in order to meet such an object, the thickness of the resin stretch sheet of the therapeutic tool according to the present invention is 0.008 mm to 0.011 mm.

According to such a configuration, flexibility and elasticity can be maintained while providing sufficient airtightness.

On the other hand, in order to meet such an object, the gel having a moisturizing effect of the therapeutic device according to the present invention is characterized by containing purified water, glycerin, carbomer, sodium polyacrisate, methylparaben and propylparaben.

According to such a configuration, the adhesiveness between the skin with scar keloid and the stretch sheet can be enhanced, and the oxygen blocking and moisturizing functions can be enhanced.

Further, in order to meet such an object, the gel having a moisturizing effect of the therapeutic tool according to the present invention is characterized by containing an alkyl methacrylate copolymer.

According to such a configuration, the hydrophilicity of the gel is enhanced, and even when the stretch sheet is peeled off, there is a film-forming effect, so that oxygen blocking and moisturizing effects can be temporarily continued.

As described above, the scar keloid treatment tool according to the present invention according to the present invention is made of an inexpensive material, has a small load on the patient, and is peeled off and lost without the person's knowledge. It has the excellent effect of being able to provide a scar keloid treatment tool.

FIG. 1 is a cross-sectional view of the skin in an intact state. FIG. 2 is a cross-sectional view of the skin of FIG. 1 in a deeply injured state. FIG. 3 is a cross-sectional view of the wounded skin keloid of FIG. FIG. 4 is a cross-sectional view of the keloid of FIG. 3 in a raised state. FIG. 5 is a cross-sectional view of the keloid of FIG. 4 in a state of being raised to the vicinity of the original epidermis. FIG. 6 is a cross-sectional view of the keloid in a raised state from the original epidermis. FIG. 7 is a diagram showing a state of a leg in which keloid is generated in a scar near the knee. FIG. 8 is a cross-sectional view of the state of FIG. 6 in which a moisturizing gel is applied. FIG. 9 is a diagram showing a state of the foot subjected to the treatment of FIG. FIG. 10 is a cross-sectional view of a state in which a stretch sheet is attached to the state of FIG. FIG. 11 is a diagram showing a state of the foot subjected to the treatment of FIG. FIG. 12 is a diagram showing a state in which the legs of FIG. 11 are bent. FIG. 13 is a photograph at the start. FIG. 14 is a photograph of the first progress of Treatment Example 1. FIG. 15 is a photograph of the second progress of Treatment Example 1. FIG. 16 is a photograph of the third progress of Treatment Example 1. FIG. 17 is a photograph of the fourth progress of Treatment Example 1. FIG. 18 is a photograph of Treatment Example 2 at the start of treatment. FIG. 19 is a photograph of the first progress of Treatment Example 2. FIG. 20 is a photograph of the second progress of Treatment Example 2. FIG. 21 is a photograph of the third progress of Treatment Example 2. FIG. 22 is a photograph of Treatment Example 3 at the start of treatment. FIG. 23 is a photograph of the first progress of Treatment Example 3. FIG. 24 is a photograph of the second progress of Treatment Example 3. FIG. 25 is a photograph of the third progress of Treatment Example 3. FIG. 26 is a photograph at the start of treatment of other therapies for comparison. FIG. 27 is a photograph of the state of FIG. 26 one year later.

Since the present invention has the above-described configuration, an embodiment of the present invention will be described with reference to the drawings.

1 to 6 are diagrams for explaining a process of producing keloid, which is a therapeutic target of the scar keloid treatment tool according to the present invention.
As shown in FIG. 1, the skin is composed of an epidermis 21, a dermis papillary layer 22, and an upper dermis net layer from the outside.
Scar keloids are caused by skin injuries, and the mechanism is as follows.

When the skin is injured as shown in FIG. 2, the epithelial cells constituting the epidermis begin to proliferate and repair.

Here, when the wound extends to the papillary dermis layer 22 and the upper dermis network 23 as shown in FIG. 2, the fibroblasts 24 start to regenerate the dermis, and at this time, the fibroblasts proliferate as shown in FIG. A cytokine called TGF-β1 that promotes the growth of dermis is produced.

As shown in FIG. 4, regarding the pathological condition in which keloid 25 rises and the boundary portion spreads around, it is involved that epithelial cells promote change to mesenchymal cells such as fibroblasts 24, and here TGF -Β1 plays a role in inducing epithelial-mesenchymal transition (EMT). As a result, mast cells and cells responsible for inflammation are induced, and keloid 25 is generated.

Epithelial cells of the epidermis undergo apoptosis (natural death) and metabolize, but keloid 25 is in a state where apoptosis is unlikely to occur, and keloid 25 generated as shown in FIG. 5 does not spontaneously disappear, and in addition, FIG. It becomes even larger due to the new enhancement of proliferation as in 6. TGF-β1 is also involved in the acquisition of apoptotic resistance of keloid 25 and prevents keloid healing.

FIG. 7 shows a state in which a wound inflicted on the knee emits keloid 31. As mentioned above, it has been thought that the keloid healing effect of the silicone sheet is due to the ability to weaken the tension of the skin and moisturize it. The effect can be expected.

Unlike the epithelium, the dermis is usually out of contact with the outside air, so it has no contact with air components and always retains adequate moisture. Here, it is considered that TGF-β1 is activated by the stimulation of oxygen, which is the main stimulating component in the air, and the stimulation of losing water by evaporation when the dermis is injured and comes into contact with the outside air. By inactivating TGF-β1, it can be expected to suppress the growth of keloids and promote the repair of the epidermis by natural metabolism.
First, it has been found that the hypoxic state of the epidermis inhibits TNF-α-induced TSLP expression in keratin-producing cells, and the increased expression of TSLP and the increased expression of TGF-β are positively correlated, and thus keloids. If the expression of TSLP is reduced by lowering the epidermis to a hypoxic state, it can be expected that the expression of TGF-β in the keloid tissue will be reduced and the growth of keloids will be suppressed.
In addition, the keloid epidermis is thinner than the normal epidermis due to the interlobar crosstalk between the keratinocytes (keratinocytes) of the epidermis and the dermal fibroblasts, so that the water evaporation amount (TEWL) of the keloid epidermis is normal. Since it is larger than the epidermis, it can be expected that the proliferation of keloids can be suppressed by lowering the TEWL of the keloid epidermis.

FIG. 8 is a cross-sectional view of the state of FIG. 6 in which purified water, glycerin, carbomer, sodium polyacrisate, methylparaben, propylparaben, and a moisturizing gel 11 containing an alkyl methacrylate copolymer are applied. FIG. 9 shows a state in which the moisturizing gel 11 is applied around the keloid 31 of FIG.
If it is dried as it is, the alkyl methacrylate copolymer forms a film to temporarily block air and moisturize, but the effect is limited.

Therefore, as shown in FIG. 10, when the stretch sheet 10 made of polyvinylidene chloride or multilayer polyolefin is attached to the skin around the keloid 25 to which the moisturizing gel 11 is applied before the moisturizing gel 11 in the state of FIG. 8 is dried. , The effect of blocking air and moisturizing continues.

FIG. 11 shows a state in which a stretch sheet 10 made of polyvinylidene chloride or multilayer polyolefin is attached to the skin in which the moisturizing gel 11 is applied around the keloid 31 of FIG. FIG. 12 shows a state in which the knee is bent with the stretch sheet 10 attached. The thickness of the stretch sheet 10 is preferably 0.008 mm to 0.011 mm so that the effect of blocking air and moisturizing continues even when the knee is bent in this way. If the thickness is within this range, the stretch sheet 10 will not come off even if the knee is bent due to the elasticity of the stretch sheet. Further, if an amorphous polymer of polyalkyl methacrylates is blended with the stretch sheet 10 made of a crystalline polymer resin, a shape memory effect can be obtained, and even if the portion to which the stretch sheet 10 is attached is bent, it becomes more difficult to peel off.

The effects are shown below with examples of treatment. The patient wears the keloid treatment tool according to the present application all day except during the period of peeling off at the time of bathing and reapplying after bathing.
13 to 17 are the treatment progress photographs of the treatment example 1.
As shown in Table 1 below, induration, ridges, redness, peripheral redness, pain, and pruritus were scored. FIG. 13 shows the treatment start date, FIG. 14 shows the state from the start of treatment to January, FIG. 15 shows the state from the start of treatment to March, FIG. 15 shows the state from the start of treatment to May, and FIG. Significant effect is seen.

18 to 21 are the treatment progress photographs of the treatment example 2.
As shown in Table 2 below, induration, ridges, redness, peripheral redness, pain, and pruritus were scored. FIG. 18 shows the treatment start date, FIG. 19 shows the state from the start of treatment to January, FIG. 20 shows the state from the start of treatment to 2.5 months, and FIG. 21 shows the state from the start of treatment to April, and significant effects can be seen in each element.

22 to 25 are the treatment progress photographs of the treatment example 3.
As shown in Table 3 below, induration, ridges, redness, peripheral redness, pain, and pruritus were scored. FIG. 22 shows the treatment start date, FIG. 23 shows the state from the start of the treatment to January, FIG. 24 shows the state from the start of the treatment to February, and FIG. 25 shows the state from the start of the treatment to March.

26 to 27 are treatment progress photographs of a treatment example using a silicon sheet for comparison.
As shown in Table 4 below, induration, ridges, redness, peripheral redness, pain, and pruritus were scored. It can be said that the keloid therapeutic tool according to the present invention has a therapeutic effect comparable to that of the silicone sheet.
It is recommended that the silicone sheet be worn for at least 2 months, 12 hours or more a day, with the start of treatment about a week after the injury.

It goes without saying that the present invention is not limited to the structure described in the above-described embodiment, and the shape, structure, etc. of each part can be appropriately modified or changed.
For example, it is possible to further prevent the stretch sheet 10 from being peeled off by attaching a component having a strong adhesive force to the entire surface or the peripheral edge of the stretch sheet 10 on the side to be attached to the skin.
If a soft gel adhesive is used as the adhesive component, it will fit tightly to the unevenness of the skin and adhere well, and it will be possible to obtain strong adhesive strength, and when peeling off, the stratum corneum on the skin surface will hardly be peeled off or damaged. You can also do it.
Of course, it goes without saying that it is not limited to these.

10 Stretch Sheet 11 Moisturizing Gel 21 Epidermis 22 Dermis Papillary Layer 23 Dermis Net Upper Layer 24 Fibroblasts 25 Keloids 30 Legs 31 Keloids

Claims (7)

A stretch sheet made of crystalline polymer resin that is airtight, flexible, and stretchable.
A gel with a moisturizing effect and
Keloid therapeutic tool characterized by being composed of The keloid treatment tool according to claim 1, wherein the stretch sheet made of a crystalline polymer resin is made of polyvinylidene chloride. The keloid treatment tool according to claim 1, wherein the stretch sheet made of a crystalline polymer resin is made of a multilayer polyolefin. The keloid therapeutic tool according to claim 1 to 3, wherein an amorphous polymer of polyalkyl methacrylates is blended on the stretch sheet made of the crystalline polymer resin. The therapeutic tool according to claim 1 to 4, wherein the resin stretch sheet has a thickness of 0.008 mm to 0.01 mm. The keloid therapeutic device according to claim 1 to 5, wherein the gel having a moisturizing effect contains purified water, glycerin, carbomer, sodium polyacrisate, methylparaben, and propylparaben. The keloid therapeutic tool according to claim 1 to 6, wherein the gel having a moisturizing effect contains an alkyl methacrylate copolymer.

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