JP2020090452A - Tranexamic acid-containing composition - Google Patents

Abstract

To provide an oily solid composition such as oil gel, in which tranexamic acid or a derivative thereof or a salt thereof are uniformly dispersed.SOLUTION: An oily solid composition contains tranexamic acid or a derivative thereof or a salt thereof, and acylamino acid ester.SELECTED DRAWING: None

Description

The present invention relates to an oily solid composition containing tranexamic acid.

Tranexamic acid and its derivatives are known to have an effect of suppressing rough skin and pigmentation, and are often used as a component to be contained in an external composition for skin such as cosmetics (Patent Documents 1 and 2). .

Further, the oily solid dosage form is commonly used in cosmetics because it can contain an oil-soluble component, can impart occlusive or moisturizing properties to the skin, and can be made into a shape such as a stick that is easy to handle. It is a dosage form.

JP, 03-007212, A Japanese Patent Laid-Open No. 01-093519

Since tranexamic acid is water-soluble, when it is contained in an oily solid composition, it is dispersed in an oily base. However, in the case of a dispersion type composition, there is a problem that the dispersed components generally settle out over time.
The present invention has been made under such circumstances, and an object thereof is to uniformly disperse tranexamic acid or a derivative thereof or a salt thereof in an oily solid composition.

In view of such a situation, the present inventors have made diligent efforts, and as a result, by incorporating tranexamic acid or a derivative thereof or a salt thereof in an oily solid composition together with an acyl amino acid ester, tranexamic acid or a derivative thereof or The present invention has been completed based on the idea that the salt can be uniformly dispersed and the dispersion stability can be achieved over time.
Furthermore, the present inventors have noted that in an oily solid composition containing tranexamic acid, the hardness decreases with time, and the coexistence of an acylamino acid ester can also maintain the hardness over time. I found that.

That is, the present invention is as follows.
[1] An oily solid composition containing tranexamic acid or a derivative thereof or a salt thereof, and an acylamino acid ester.
[2] The composition according to [1], wherein the content of the acyl amino acid ester is 0.1 to 10 mass% of the entire composition.
[3] The composition according to [1] or [2], which further contains a sorbitan surfactant.
[4] The composition according to any one of [1] to [3], which further contains a powder.
[5] The composition according to [4], wherein the content of the powder is 0.5 to 40 mass% of the entire composition.
[6] The composition according to any one of [1] to [5], which contains 5% by mass or more of a solid fat and/or a semisolid fat.
[7] The composition according to any one of [1] to [6], which is an external preparation for skin.

ADVANTAGE OF THE INVENTION According to this invention, the oily solid composition in which the uniform dispersibility of the tranexamic acid or its derivative(s) or its salt was improved is provided. Further, the oily solid composition of the present invention has an effect of maintaining hardness over time and an effect of suppressing precipitation of tranexamic acids.

The composition of the present invention essentially contains tranexamic acid or a derivative thereof or a salt thereof (also referred to as “tranexamic acids” in the present specification).
Tranexamic acid refers to trans-4-aminomethylcyclohexane-1-carboxylic acid.

The derivative of tranexamic acid is not particularly limited, and examples thereof include esters and amides.Examples of the ester of tranexamic acid include lauryl ester of tranexamic acid, hexadecyl ester of tranexamic acid, cetyl ester of tranexamic acid, and amide of tranexamic acid. Examples of the body include tranexamic acid methylamide.

As salts of tranexamic acid or its derivatives, alkali metal salts such as sodium salts and potassium salts; alkaline earth metal salts such as calcium salts and magnesium salts; zinc salts; iron salts; ammonium salts; arginine, histidine, lysine , Salts with basic amino acids such as ornithine; salts with amines such as monoethanolamine, diethanolamine, triethanolamine and the like. Of these, sodium salt, potassium salt, triethanolamine salt, and arginine salt are preferable for the embodiment of the external preparation for skin described below.

The content of tranexamic acids in the composition of the present invention is not particularly limited, but is preferably 0.01 to 5% by mass, more preferably 1 to 3% by mass, based on the entire composition. By including it in such a range, it becomes easy to exhibit the anti-inflammatory (suppression of skin roughness) effect and the whitening (suppression of pigmentation) effect exhibited by tranexamic acids.

The composition of the present invention essentially contains an acyl amino acid ester.
By including the component together with tranexamic acids in the oily solid composition, the tranexamic acids can be uniformly dispersed in the composition, and the uniform dispersibility can be maintained over time. Further, even in an oily solid composition containing tranexamic acids, the hardness can be maintained without deterioration over time. Further, generally, tranexamic acids are liable to be deposited, and cosmetics and the like containing them may be difficult to store. However, the coexistence of an acylamino acid ester can suppress the deposition.

Acyl amino acid ester is an ester of an acyl amino acid and alcohols.
The acylamino acid moiety is not particularly limited, but N-acyl acidic amino acids are preferable, N-acyl aspartic acid or N-acyl glutamic acid is more preferable, and N-acyl glutamic acid is further preferable. These amino acid structures may be optically active or racemic.
The acyl group is preferably an acyl group derived from a saturated or unsaturated fatty acid having 8 to 22 carbon atoms, for example, an acyl group derived from a fatty acid having a single composition such as lauric acid, palmitic acid, stearic acid, oleic acid. Alternatively, it may be an acyl group of a naturally occurring mixed fatty acid such as coconut oil fatty acid, beef tallow fatty acid, hardened beef tallow fatty acid or the like, or a synthetically obtained fatty acid (including a branched fatty acid).

The group that forms an ester moiety is not particularly limited, but is a sterol, a carbon number of 8 to 3
Preferred are liquid higher alkyls of 0 or alkenyl alcohols, solid higher alkyl alcohols having 12 to 38 carbon atoms, and the like. In the case of N-acyl acidic amino acid ester, it may be a monoester or a diester, but it is particularly preferable that at least one of the two ester-forming residues is a sterol residue. .. The sterol may be animal-derived or plant-derived, and examples thereof include cholesterol, phytosterol, and hydrogenated products thereof. Further, the liquid higher alkyl or alkenyl alcohol having 8 to 30 carbon atoms is a natural or synthetic aliphatic alcohol having 8 to 30 carbon atoms and is in a liquid state at room temperature, for example, a branched alcohol such as 2-octyldodecyl alcohol. And unsaturated alcohols such as oleyl alcohol. The solid higher alkyl alcohol having 12 to 38 carbon atoms is a saturated monohydric alcohol having 12 to 38 carbon atoms and is solid at room temperature, and examples thereof include cetyl alcohol and behenyl alcohol.

Specifically, N-lauroyl-L-glutamate di(octyldodecyl/phytosteryl/behenyl), N-lauroyl-L-glutamate di(phytosteryl/2-octyldodecyl), N-lauroyl-L-glutamic acid di(cholesteryl/ Behenyl/octyldodecyl), N-lauroyl-L-glutamate di(cholesteryl/octyldodecyl), and the like. Of these, di-N-lauroyl glutamate (octyldodecyl/phytosteryl/behenyl) is particularly preferred.

These are generally commercially available, such as "Eldew PS203", "Eldew CL-301", "Eldew Cl-202", "Eldew PS-304" and "Eldew PS-306" which are sold by Ajinomoto Co., Inc. It can be illustrated.

The acyl amino acid ester may be used alone or in any combination of two or more. They may be used alone or in combination of two or more.
The content of the acylamino acid ester in the composition of the present invention is not particularly limited, but is preferably 0.1 to 10% by mass, more preferably 2 to 8% by mass, based on the entire composition. By including it in such a range, it becomes easy to exert the effect of uniform dispersibility of tranexamic acids and the effect of maintaining the hardness of the composition over time.

The composition of the present invention preferably further contains a sorbitan-based surfactant from the viewpoint of further improving the uniform dispersibility of tranexamic acids.
The sorbitan-based surfactant is not particularly limited, but sorbitan fatty acid esters such as sorbitan monostearate, sorbitan sesquiisostearate, sorbitan sesquioleate; POE sorbitan monooleate, polyoxyethylene sorbitan monostearate, etc. Sorbitan fatty acid esters; POE-sorbit monolaurate and other POE sorbit fatty acid esters. Of these, sorbitan fatty acid esters are more preferred, and sorbitan sesquiisostearate is even more preferred.
Although the content of the sorbitan surfactant in the composition of the present invention is not particularly limited, it is preferably 0.1 to 5% by mass, more preferably 0.5 to 3% by mass, based on the entire composition. When the content is within such a range, the effect of uniformly dispersing tranexamic acids can be more easily exhibited.

In the present invention, the oily solid composition refers to a solid cosmetic material which is substantially free of water and an aqueous component and has an oil agent as a base material.
Here, the solid includes a semi-solid and usually has a high viscosity and low fluidity. For example, a material having no fluidity at 25°C is preferable. Further, the viscosity at 25° C. is preferably 20,000 Pa·s or more. With such a formulation, the tranexamic acids are unlikely to settle down over time, and a composition having excellent dispersion stability over time can be obtained.
The term "substantially free" is preferably 0.1% by mass or less, more preferably 0.01% by mass or less, and further preferably 0.001% by mass or less, based on the entire composition. There is something. The aqueous component means, for example, a component suspended in mineral oil at 25 to 65° C., left standing for 1 hour, and then phase-separated from the mineral oil.

The oil agent which can serve as a base material in the oily solid composition of the present invention is usually a solid fat and/or a semisolid fat. Since the viscosity of the composition is increased by the inclusion of solid fats and semi-solid fats, tranexamic acids dispersed in the composition is less likely to sediment over time, and a composition excellent in dispersion stability over time Can be. This aspect is suitable for the oil gel formulation and the like described later.
Further, an oil agent (including a fluid oil agent such as a liquid oil agent) usually used in cosmetics may be added.
The type and content of the oil agent are not particularly limited, and may be appropriately adjusted depending on the desired hardness, reduction of whiteness of the powder on the skin after application, usability such as adhesion to the skin and slippage during application. Good.

The content of solid fats and/or semisolid fats and oils is preferably 5% by mass or more, more preferably 8% by mass, and further preferably 12% by mass or more of the total composition. Moreover, 50 mass% or less of the whole composition is preferable, 40 mass% or less is more preferable, and 30 mass% or less is further preferable.

Here, the solid in the solid fats and oils refers to those that do not have fluidity at 25°C, and the semisolid in the semisolid fats and oils hardly deforms in an environment where there is no stress at 1 atm and 20°C, but some stress (10 (About 100 g/cm ² ) means that it is deformed. Further, those having a melting point of 50° C. or higher are more preferable.
Examples of solid fats and/or semi-solid fats and oils include plant-derived ones such as carnauba wax, mokuro, candelilla wax, rice bran wax, shea butter, and African mango butter, and animal-derived ones such as beeswax, shellac wax, and ibotaro. Examples thereof include petroleum-derived waxes such as paraffin wax and microcrystalline wax, and mineral-derived waxes such as ozokerite, ceresin and montan wax. These solid fats and/or semisolid fats and oils can be used alone or in combination of two or more kinds.

Examples of other oil agents that can serve as a base material in the composition of the present invention include oil agents that are usually used in cosmetics (including fluid oil agents such as liquid oil agents).
Such other oil agents include macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, coconut oil, palm oil, liquid lanolin, hardened coconut oil, hardened oil. Oils, waxes such as, syrup, hydrogenated castor oil, beeswax, candelilla wax, carnauba wax, ivota wax, lanolin, reduced lanolin, hard lanolin, jojoba wax; liquid paraffin, squalane, pristane, ozokerite, paraffin, ceresin, vaseline, microcrystalline Hydrocarbons such as waxes; higher fatty acids such as oleic acid, isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid; cetyl alcohol, stearyl alcohol, isostearyl alcohol, behenyl alcohol, octyldodeca Higher alcohols such as norol, myristyl alcohol and cetostearyl alcohol; cetyl isooctanoate, isopropyl myristate, hexyldecyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, cetyl lactate, diisostearyl malate, di- Ethylene glycol 2-ethylhexanoate, neopentyl glycol dicaprate, glycerin di-2-heptylundecanoate, glyceryl tri-2-ethylhexanoate, trimethylolpropane tri-2-ethylhexanoate, trimethylolpropane triisostearate, Synthetic ester oils such as penta-2-ethylhexanoic acid pentane erythritol; Not classified into the above silicones such as amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, fluorine-modified polysiloxane and other modified polysiloxane Oil agents such as silicone oil may be mentioned.

The composition of the present invention preferably further contains a powder. Since the viscosity of the composition is increased by including the powder, the tranexamic acids dispersed in the composition are less likely to settle over time, and the composition can be excellent in dispersion stability over time. This aspect is suitable for the oil gel formulation and the like described later.
The content of the powder is preferably 0.5 to 40% by mass, more preferably 1 to 30% by mass, based on the entire composition.

As the powder, the surface may be treated, silica (anhydrous silicic acid), mica, talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, aluminum oxide, barium sulfate, etc. powder, bentonite, Clay minerals such as hectorite, which may be surface-treated, red iron oxide, yellow iron oxide, black iron oxide, cobalt oxide, ultramarine blue, navy blue, titanium oxide, inorganic pigments of zinc oxide, which may be surface-treated Good, pearl agents such as mica titanium, fish phosphorus foil, bismuth oxychloride, etc., red 202, red 228, red 226, yellow 4, blue 404, yellow 5 and red, which may be laked. Organic dyes such as 505, red 230, red 223, orange 201, red 213, yellow 204, yellow 203, blue 1, green 201, purple 201 and red 204, polyester powder , Polyamide powder, polyethylene powder, polymethylmethacrylate, nylon powder, organic powders such as organopolysiloxane elastomer, and the like.
The shape is not particularly limited, and examples thereof include spheres, hemispheres, and plates that are generally used for external preparations for skin such as cosmetics, and may be porous.
The particle size may be such that it is generally used for external preparations for skin such as cosmetics, but a fine particle size in the form of fumes (for example, 5 nm to 20 nm) is particularly preferable.
Of these, fumed silica (fumed silica) is particularly preferable in the present invention from the viewpoint of dispersion stability of the composition, and commercially available products may be used.

The oily solid composition of the present invention is preferably in the form of oil gel.
When the composition of the present invention is in the form of oil gel, it is preferable to contain an oily gelling agent in addition to or in place of the above-mentioned solid fat and oil or semi-solid fat and oil. Since the viscosity of the composition is increased by containing the oily gelling agent, the tranexamic acids dispersed in the composition are unlikely to settle down over time, and the composition may have excellent dispersion stability over time. ..
Here, the oily gelling agent refers to a gelling agent that is compatible with an oily component such as an oily agent, and is not particularly limited, but 12-hydroxystearic acid, dextrin palmitate, (palmitic acid/octanoic acid) dextrin, dibutyl Examples include lauroyl glutamide and dimethicone crosspolymer.
The content of the oily gelling agent is preferably 0.5 to 20% by mass, more preferably 2 to 15% by mass, and even more preferably 3 to 10% by mass of the entire composition.

The composition of the present invention has high dispersion stability of tranexamic acids in the composition over time. Specifically, it means that no precipitation of the compound is visually observed after standing at 40° C. for 1 day. Alternatively, after standing at 40° C. for 1 day, the composition above 95 v/v
The difference in the concentration of the compound between% and lower 95 v/v% is preferably within 10%, more preferably within 5%, even more preferably within 0.5%.

The composition of the present invention, as described above, tranexamic acids can exhibit anti-inflammatory (suppression of skin roughness) and whitening (suppression of pigmentation) effects, and thus can be suitably used as an external preparation for skin and more suitable for application to cosmetics. preferable. The cosmetics include quasi-drugs.

In addition to such components, the composition of the present invention may optionally contain optional components used in ordinary skin external preparations as long as the effects of the present invention are not impaired. Examples of such optional ingredients include various active ingredients, oily ingredients, other surfactants, polyhydric alcohols, thickeners, and ultraviolet absorbers.

Examples of the active ingredient include other whitening ingredients, wrinkle-improving ingredients, other anti-inflammatory ingredients, extracts derived from plants and animals, and the like.
Other whitening ingredients are not particularly limited as long as they are generally used in cosmetics. For example, 4-n-butyl resorcinol, ascorbic acid glucoside, 3-O-ethylascorbic acid, arbutin, ellagic acid, kojic acid, linoleic acid, nicotinic acid amide, 5,5′-dipropylbiphenyl-2,2′- Examples thereof include diol, 5'-adenylate disodium salt, cetyl tranexamic acid, 4-methoxysalicylic acid potassium salt, hydroquinone, and pantothenic acid.

The wrinkle improving component is not particularly limited as long as it is generally used in cosmetics. For example, nicotinic acid amide, vitamin A or a derivative thereof (retinol, retinal, retinoic acid, tretinoin, isotretinoin, tocopherol retinoic acid, retinol palmitate, retinol acetate, etc.), ursolic acid benzyl ester, ursolic acid phosphoric acid ester, betulinic acid. Examples thereof include benzyl ester and benzyl phosphate.

Other anti-inflammatory components include clarinone, glabridin, glycyrrhizinic acid, glycyrrhetinic acid, pantothenyl alcohol and the like, preferably glycyrrhizinic acid and its salts, alkyl glycyrrhetinic acid and its salts, and glycyrrhetinic acid and its salts. is there.

The extract derived from animals and plants is not particularly limited as long as it is generally used in cosmetics. For example, akebi extract, asunaro extract, asparagus extract, avocado extract, armature extract, almond extract, arnica extract, aloe extract, aronia extract, apricot extract, ginkgo extract, indoquino extract, fennel extract, udo extract, age extract, eleuthero extract. , Crassulaceae extract, Scutellaria extract, Scutellaria extract, Scutellaria extract, Panax ginseng extract, Hypericum perforatum extract, Stinkweed extract, Orange extract, Kakigoku extract, Cuckoo extract, Chamomile extract, Carrot extract, Kawamura Yomogi extract, Kanzo extract, Kiwi extract, Cucumber extract, Guava extract, Kujin extract, Gardenia extract, Kumazasa extract, Clara extract, Walnut extract, Grapefruit extract, Black rice extract, Chlorella extract, Mulberry extract, Cake extract, Gett extract, Gentiana extract, Gentian ginger extract, Black tea extract, Burdock extract, Rice extract, Fermented rice extract, fermented rice bran extract, rice germ oil, cowberry extract, salvia extract, saponsou extract, sasa extract, hawthorn extract, sangsha extract, salamander extract, shiitake extract, dio extract, shikon extract, perilla extract, linden extract, spirea extract, peony root. Extract, ginger extract, ginger root extract, birch extract, horse mackerel extract, stevia extract, stevia fermented product, hawthorn extract, hawthorn extract, hawthorn extract, halibut extract, hazelnut extract, sage extract, mallow extract, senkyu Extract, assembly extract, sow extract, rhubarb extract, soybean extract, turmeric extract, thyme extract, dandelion extract, tea extract, clove extract, chimpi extract, black tea extract, capsicum extract, spruce extract, daffodil extract, spruce extract, spruce extract, duckweed extract , Tomato extract, natto extract, carrot extract, garlic extract, nobara extract, hibiscus extract, bakumondou extract, lotus extract, parsley extract, birch extract, hamamelis extract, Hikiokoshi extract, cypress extract, loquat extract, coltsfoot extract, butterbur extract, butterbur extract , Butcher bloom extract, grape extract, grape seed extract, loofah extract, safflower extract, peppermint extract, bo Daiju extract, button extract, hop extract, pine extract, mayonnaise extract, horse chestnut extract, hornwort extract, sorghum extract, melissa extract, mozuku extract, peach extract, cornflower extract, eucalyptus extract, yukinoshita extract, yuzu extract, lily extract, yokuinin extract, mugwort extract, lavender extract. Extracts such as green tea extract, green tea extract, apple extract, rooibos tea extract, litchi extract, lettuce extract, lemon extract, forsythia extract, astragalus extract, rose extract, rosemary extract, Roman chamomile extract, royal jelly extract, and oleander extract are preferred. Can be mentioned.

Other surfactants include fatty acid soaps (sodium laurate, sodium palmitate, etc.), anionic surfactants such as potassium lauryl sulfate, triethanolamine ether alkylsulfate, stearyltrimethylammonium chloride, benzalkonium chloride, lauryl. Cationic surfactants such as amine oxide, betaine-based surfactants (alkylbetaine, amidobetaine, sulfobetaine, etc.), imidazoline-based amphoteric surfactants (2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyl ester) Roxy disodium salt, etc.), amphoteric surfactants such as acylmethyl taurine,
Polyglyceryl sesquiisostearate, glycerin fatty acid esters (glyceryl monostearate, etc.), propylene glycol fatty acid esters (propylene glycol monostearate, etc.), hydrogenated castor oil derivative, glycerin alkyl ether, POE glycerin fatty acid esters (POE-glycerin mono) Isostearate, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE distearate, etc.), POE alkyl ethers (POE2-octyldodecyl ether, etc.), POE alkylphenyl ethers (POE nonylphenyl ether, etc.), pluronic types , POE/POP alkyl ethers (POE/POP2-decyl tetradecyl ether, etc.), Tetronics, POE castor oil, hydrogenated castor oil derivatives (POE castor oil, POE hydrogenated castor oil, etc.), sucrose fatty acid ester, alkyl glucoside Nonionic surfactants such as and the like.

Polyhydric alcohols include polyethylene glycol, glycerin, 1,3-butylene glycol, erythritol, sorbitol, xylitol, maltitol, propylene glycol, dipropylene glycol, diglycerin, isoprene glycol, 1,2-pentanediol, 2,4. -Hexylene glycol, 1,2-hexanediol, 1,2-octanediol and the like.

As the thickener, guar gum, quince seed, carrageenan, galactan, gum arabic, pectin, mannan, starch, xanthan gum, curdlan, methyl cellulose, hydroxyethyl cellulose, carboxymethyl cellulose, methyl hydroxypropyl cellulose, chondroitin sulfate, dermatan sulfate, glycogen, Heparan sulfate, hyaluronic acid, sodium hyaluronate, tragacanth gum, keratan sulfate, chondroitin, mucoitin sulfate, hydroxyethyl guar gum, carboxymethyl guar gum, dextran, keratosulfate, locust bean gum, succinoglucan, caronic acid, chitin, chitosan, carboxymethyl Examples thereof include chitin, agar, polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, alkyl-modified carboxyvinyl polymer, sodium polyacrylate, polyethylene glycol and the like.

As the ultraviolet absorber, para-aminobenzoic acid type ultraviolet absorber, anthranilic acid type ultraviolet absorber, salicylic acid type ultraviolet absorber, cinnamic acid type ultraviolet absorber, benzophenone type ultraviolet absorber, sugar type ultraviolet absorber, 2-(2 Examples thereof include ultraviolet absorbers such as'-hydroxy-5'-t-octylphenyl)benzotriazole and 4-methoxy-4'-t-butyldibenzoylmethane.

The composition of the present invention can be produced by treating the above-mentioned essential components, preferred components, optional components and the like according to a conventional method.

Hereinafter, the present invention will be described in more detail with reference to Examples, but it goes without saying that the present invention is not limited to such Examples.

<Production example>
An emulsifier type external preparation for skin was produced according to the formulation shown in Table 1 below. That is, the component B was heated and melted at 95° C. and mixed. Further, Component A was added to the above mixture while stirring with a disper at 3000 rpm for 1 minute at 95°C. After that, defoaming was performed, the mixture was filled in a container, and solidified by cooling to obtain an oily solid cosmetic.

<Test example>
(1) Evaluation of Dispersion Stability After the prepared oily solid cosmetics were allowed to stand at 40° C. for 1 day, the presence or absence of sedimentation of tranexamic acid was visually observed, and the dispersion stability was confirmed when they were uniformly dispersed. ◯, dispersibility was evaluated as Δ when slight sedimentation was observed but not observed without staring, and dispersion stability was evaluated as x when sedimentation was observed. The results are also shown in Table 1.

(2) Evaluation of Hardness Each of the prepared oily solid cosmetics was left for 1 month in an aging box set to change from 0°C to 40°C in 24 hours, and then left in a thermostatic chamber at 20°C for 2 hours, Then, the hardness was measured using a card meter (manufactured by Aitechno Engineering Co., Ltd.). The hardness after leaving for 3 months when the hardness immediately after preparation was 100% was defined as the maintenance rate. When the hardness retention rate was 80% or more, it was evaluated as ◯, when 51 to 79% was evaluated as Δ, and when the change with time was 50% or less, it was evaluated as x. The results are also shown in Table 1.

(3) Evaluation of precipitation of tranexamic acid Each prepared oily solid cosmetic was allowed to stand at 40°C for 1 month, and the presence or absence of precipitation of tranexamic acid was visually confirmed on the surface of the oily solid cosmetic. The results are also shown in Table 1.

The present invention can be applied to skin external preparations such as cosmetics.

Claims (7)

An oily solid composition containing tranexamic acid or a derivative thereof or a salt thereof, and an acylamino acid ester. The composition according to claim 1, wherein the content of the acyl amino acid ester is 0.1 to 10 mass% of the entire composition. The composition according to claim 1, further comprising a sorbitan surfactant. The composition according to any one of claims 1 to 3, further comprising a powder. The composition according to claim 4, wherein the content of the powder is 0.5 to 40% by mass of the entire composition. The composition according to any one of claims 1 to 5, which comprises 5% by mass or more of solid fat and/or semisolid fat in the entire composition. The composition according to any one of claims 1 to 6, which is a skin external preparation.