JP2020065808A - Pressure type medicine injector - Google Patents

Abstract

To provide a portable anticancer agent container for preventing exposure and infection to a human body by leakage of a medicinal solution caused by a connection connector removing operation in system cleaning using cleaning fluid.SOLUTION: A pressure type medicine injector includes: a reservoir having a medicinal solution replenishing port and a medicinal solution discharge port; pressure-deforming means for pressure-deforming a medicinal solution storage part by the injection of a medicinal solution and pushing out the medicinal solution by a force by which the medicinal solution storage part is restored to its original shape from the pressure deformation; flow rate control means for adjusting a flow rate of a medicinal solution by resistance; a system cleaning port having a cleaning fluid injection port, a medicinal solution replenishing port, and a fluid discharge port; and a case for enclosing the flow rate control means and the system cleaning port. The replenished medicinal solution is replenished to the pressure-deforming means through the medicinal solution replenishing port of the reservoir, and moves to the outside of the container from the medicinal solution discharge port of the reservoir through the flow rate control means. The cleaning fluid is injected from the injection port of the cleaning port arranged on the downstream of the flow rate control means, and moves to the outside of the container. The periphery of the cleaning port is entirely covered with a sterilization seal, and is kept clean until the time of use.SELECTED DRAWING: Figure 3

Description

  FIELD OF THE INVENTION The present invention relates to a pressurized drug injector with an irrigation fluid injection port.

  According to the announcement by the National Cancer Center Hospital in 2013, the total number of cancer cases in Japan is 862,452, and the treatment is being carried out all over the country. The current three major cancer treatments are surgery (surgical treatment), drug therapy (chemotherapy), and radiation therapy, as well as IVR (catheter therapy), hematopoietic stem cell transplantation, immunotherapy, and alternatives. There is "therapy" etc., and depending on the cancer type, stage (progress status), patient background, etc., the above treatment method is selected individually or multiple times under the guidance of each specialist doctor for each patient and multimodality treatment is performed. .

  Among them, chemotherapy has the effect of suppressing the growth of cancer cells and preventing recurrence and metastasis by using anticancer agents. Anticancer drugs may be treated with only one type of drug or may be treated with a combination of several types of drugs. Depending on the type of drug, it is orally or instilled, subcutaneously injected, or directly administered to other organs. Therefore, the purpose and timing of implementation vary depending on the cancer type, stage (progression of medical condition), lifestyle, and the like. Usually, the administration period is divided into several times for several weeks to several months.

  In addition, colorectal cancer (2nd place by site) and breast cancer (4th place by site) are the main cancer types for which chemotherapy is often introduced because of good drug response and high treatment results. The main drug solution administration schedule for colorectal cancer chemotherapy is continuous intravenous administration of 46 to 48 hours once every two weeks, and the drug is administered using a portable pressurized liquid injection pump. In many cases. In addition, chemotherapy for breast cancer is also carried out by intravenous infusion mainly for spontaneous infusion, and continuous administration for 15 to 90 minutes per one time is performed every 21 to 28 days for one course.

  If these drugs are continuously and repeatedly administered via a vein for a short period of time, there will be pain for the patient (1) to secure the blood vessel with the injection needle each time, and (2) the route of infusion will be connected during administration. (3) Intravenous injection uses peripheral veins such as elbows or wrists, but their blood vessels are thin, and administration of high-concentration anticancer drugs causes severe pain due to osmotic pressure. There are problems that vascular pain may occur, and (4) if intravenous injection is performed, if the vein is thin or obstructed, it may be necessary to repeatedly puncture the injection needle. To alleviate these problems, insert the tip of a tube thinner than a resin vessel called a catheter into the central superior vein, and insert a silicone septum (repeated Huber needle ( A CV port has been developed that can be implanted subcutaneously by connecting it to a device that has a needle (for port-specific needle) that can be punctured) and is widely used in patients receiving anti-cancer drug treatment. When using the CV port, the Huber needle is used, and when the drug solution is not administered, the needle can be withdrawn to release from the drip line.

  In addition, the current chemotherapy is carried out based on evidence in various clinical trials, and it has been proved that the therapeutic effect is further improved by continuously administering some anticancer agents. From the results of the treatment, FOLFOX6 / FOLFIRI therapy, which is a continuous chemotherapy with anti-cancer drugs for 46 to 48 hours, has become the world standard treatment for typical colorectal cancer chemotherapy. In addition, depending on the regimen, the drug may be continuously administered for 7 days, and the patient is forced to rest due to hospitalization because the patient is connected to the infusion route. Therefore, in recent years, a portable balloon-type drug solution injector has been developed, and by using it in combination with the above-mentioned CV port system, the patient is released from the infusion route even during drug solution administration, so that treatment can be performed at an outpatient or home level. Became.

  As this anticancer drug administration system, a drug solution filling port called CV port is surgically placed on the patient's body, for example, the chest, the upper arm or the forearm, and the patient's skin is pierced through the placed CV port. Pressurized drug injectors that are puncturable with a Huber needle and can be carried through the Huber needle (and the connecting tube) are widely known.

  When completing the injection of the drug solution from the CV port, wash the drug solution remaining in the port and the catheter, and use a cleaning solution from a Huber needle to prevent thrombus formation due to reverse blood and blockage in the catheter due to changes in the composition of the drug. It is necessary to wash the inside of the CV port (hereinafter referred to as system washing) with (saline solution or heparinized saline solution).

  BACKGROUND ART As a portable pressurized pharmaceutical injecting device used for conventional administration of anticancer agents, a medical liquid storage container as shown in Patent Document 1 is known. This medical liquid storage container is a pressurization type drug injector that pushes the drug solution out of the container by the contracting force of the balloon by introducing and expanding the drug solution into the balloon.

  However, in the invention described in Patent Document 1, when performing system cleaning of the CV port, Huber needle and tube after administration of the drug solution, the tube connector of the pressurized pharmaceutical injector is detached from the tube connector of the Huber needle and separately prepared. It is necessary to connect the syringe containing the physiological saline solution or the physiological saline containing heparin (hereinafter referred to as a syringe containing a cleaning solution) to the tube connector of the Huber needle to perform the cleaning operation. It is known that this operation is not only complicated for the patient or the user, but also that the risk of infection or leakage of the drug solution or cleaning solution is increased in the operation of connecting and replacing the route. In particular, if an anti-cancer drug leaks from the route and is exposed to the human body, it may cause serious complications such as injury or damage to the human body. As a means for preventing this, conventionally, it has been carried out by an uncertain and complicated method such as wearing gloves so as not to be exposed to the leaked medicine, and carefully handling the members.

  When medical fluid injection from a portable pressurized pharmaceutical infuser containing an anti-cancer drug is completed, medical personnel or patients and their families (hereinafter referred to as users) must perform the above system cleaning. , Generally, remove the connection between the pressurized drug injector and the Huber needle and connect the syringe containing the cleaning solution to clean the system, or use the unevenness that is attached to the route of the pressurized drug injector and the Huber needle. System-cleaning is performed by connecting a syringe containing a cleaning solution to a connection connector (three-way stopcock, Y connector, etc.) that can be connected in shape. It can be said that this operation is always exposed to the exposure to the anticancer drug, the droplets, and the cause of infection because the tube filled with the anticancer drug is once opened and connected.

JP, 2005-181822, A

  Therefore, it is an object of the present invention to provide a portable pressurized drug injector for preventing leakage of a chemical solution or cleaning solution, exposure to a human body, and infection during system cleaning using a cleaning solution.

In order to achieve the above-mentioned object, the present invention is a pressurized drug injector having a system cleaning function, such as a liquid medicine filling port for filling a liquid medicine in a reservoir, a balloon having a pressure capable of storing the liquid medicine and discharging the liquid medicine. (Including a tank that can be filled with a drug and has a pressurizing function), a flow rate control tube (which may be a flow rate control tube, etc.) that adjusts the flow rate of the drug discharged by pressure from a balloon, etc. It is made up of a container that contains an infusion filter that prevents the entry of air and bacteria and a chemical injection port of the system cleaning port.
The container has a chemical solution filling port, a system cleaning solution injection port and a chemical solution discharge port, and the chemical solution filled in the balloon is a chemical solution discharge port of a reservoir → infusion filter → flow control tube → system. It is a pressurized pharmaceutical injector characterized in that the cleaning port is moved to the outside through each communication means such as a tube.

  In the case of the pressurized drug injector of this configuration, the system cleaning port is installed as one unit inside, so the connector equipped on the tube etc. can be installed in the stem cleaning that the user has been performing until the end of drug solution administration. It is not necessary to perform the replacement operation of the syringe containing the removed cleaning liquid. Therefore, when the user cleans the system such as the CV port, the chemical liquid or the cleaning liquid does not leak outside, and the chemical liquid is prevented from being exposed to the user, everyone who handles this product, and the surrounding people. Therefore, it can be said that use is simple and safe for the patient or the user in that careful handling operation for preventing drug exposure and excessive prevention and trouble in preparation for leakage are unnecessary.

  Further, according to the pressurized pharmaceutical injector of this configuration, since the chemical solution filling port for injecting the chemical solution and the system cleaning port inlet are all arranged inside the container, it is possible to perform the filling / injecting operation of the chemical solution or the cleaning solution. It is possible to prevent leakage and exposure of chemicals.

  The liquid medicine filling port and the system cleaning port inlet have a connector function (screw hole) that fits with the tip of the medical device syringe in order to introduce the liquid medicine and the liquid cleaning.

  The medical device connected to the drug solution filling / system cleaning port injection port of the pressurized drug injector with this configuration can be fixed by screw fitting, and the injection pressure is generated between the syringe and each filling port when injecting the drug solution. The stress that tends to separate due to the repulsive action can be suppressed, and the operation can be performed safely, easily, and with peace of mind.

  The opening of the system cleaning port inlet of the container is preferably sealed by a removable sealing member.

It is one of the most important measures to prevent the contamination (introducing bacteria causing infections into the body by operation) that occurs during the system cleaning operation.
With the pressurized pharmaceutical injection device with this configuration, the system cleaning port inlet and the surrounding area of the opening are sealed with a clean sealing member until just before the system cleaning operation, maintaining a sterile condition and preventing contamination due to connection operation. However, the system cleaning operation that is safe for the patient becomes possible.

  With the pressurized drug injector of this configuration, the flow rate of the drug can be adjusted according to the purpose of use, regardless of the nature of the drug and the patient, and while being highly portable, it can be widely used for various drugs and patients. Applicable. In addition, the flow rate is controlled between the balloon and the drug outlet, and the system cleaning port inlet is installed on the downstream side of the flow control pipe so that when the chemical solution is injected from the system cleaning inlet, the upstream side is connected by the resistance of the flow control pipe. Since the internal pressure increases and the downstream side is connected to the vein via the CV port indwelling in the patient, the cleaning solution cannot flow to the upstream of the flush port due to the pressure difference, and the cleaning solution flows into the downstream side and the system cleaning is performed. Is possible.

  Immediately before the flow control pipe, it is desirable to provide an infusion filter that suppresses passage of particles and air having a predetermined diameter or less. The infusion filter has hydrophobic and hydrophilic membranes.

  With the pressurized pharmaceutical infusion device of this configuration, since an infusion filter is provided in the flow path through which the drug passes, it is possible to provide a simpler, safer, more portable medication for the patient without preparing an infusion filter separately. Become.

A tube is used as a communication means for each member of the chemical solution outlet, the infusion filter, the flow rate control tube, and the system cleaning port, which is arranged in the container, but the tube can be wrapped with a spiral cut on the outer peripheral portion. It is preferable to provide a substantially cylindrical tube winding portion.
As a result, even if a long tube is used, it can be placed in the container, and a compact pressurized drug injector can be provided.

  According to the pressurized pharmaceutical injector of the present invention, when the user cleans the system, the chemical liquid or the cleaning liquid does not leak to the outside, the exposure to the user and the surrounding persons is prevented, and the chemical liquid or the cleaning liquid is prevented. Leakage and exposure can be prevented even when filling the pressurized drug injector. Therefore, it is also beneficial for the user that the mental burden of wearing gloves and careful operation is reduced to prevent exposure.

  Further, in the case of the pressurized pharmaceutical injector of this configuration, when introducing the chemical liquid or the cleaning liquid, all the chemical liquid injection ports can be fixed by screw fitting with the medical syringe, and by the repulsive force of the chemical liquid at the time of injection. The generated separation can be suppressed and the operation can be performed safely and easily.

Furthermore, according to the pressurized pharmaceutical injector of the present invention, a flexible and strong resinous material is used so that the user does not directly apply impact or stress to the balloon containing the liquid medicine due to a mistaken operation such as a drop during administration of the liquid medicine. The container absorbs the shock. In the unlikely event that the balloon is damaged and liquid leakage occurs, the above-mentioned container uses a hydrophobic air filter so that the chemical liquid does not leak to the outside of the container.
As a result, it is possible to prevent the exposure of the user and surrounding people. Further, even when dropped, the chemical solution filling port and the system cleaning port inside are not directly impacted, and damage can be prevented.

The example of the schematic diagram of the flow path of the chemical | medical solution in the pressurization type | mold pharmaceutical injector of this invention is shown. The schematic diagram of the other flow path of the chemical | medical solution in the pressurization type | mold pharmaceutical injector of this invention is shown. FIG. 6 shows still another schematic view of the flow path of the drug solution in the pressurized pharmaceutical injector of the present invention. 1 shows a perspective view of an example of a pressurized pharmaceutical infusion device of the present invention. The perspective view seen from the back side of FIG. 4 is shown. (A) is a cross-sectional perspective view of one of the pressurized drug injectors taken along the line A-A 'in FIG. 4, and (b) is the other pressurized drug injector taken along the line A-A' of FIG. FIG.

Hereinafter, the pressurized pharmaceutical infusion device of the present invention will be described with reference to the drawings.
1, FIG. 2 and FIG. 3 are schematic diagram examples showing the flow paths of the chemical liquid and the cleaning liquid of the specific configuration example (see FIGS. 4 to 6) of the pressurized pharmaceutical injecting device of the present invention. The pressurized pharmaceutical injector will be described in detail with reference to the schematic diagrams of FIGS. 1, 2 and 3. Each member name will be described in detail after the description of the flow path.

  1 (a), 1 (b), 2 (a), 2 (d), and 3 show an example of the flow path of the pressurized pharmaceutical injector 1 according to the embodiment of the present invention shown in FIGS. ing. According to the flow path of FIG. 1A, after filling the balloon 50 with the liquid medicine from the liquid medicine filling port of the main pressurization type pharmaceutical injector 1, the liquid medicine outlet 8d of the reservoir 8 is passed through the first tube (not shown). It moves to the infusion filter 14, moves from the infusion filter 14 to the flow rate control pipe 11 via the second tube (not shown), and introduces the cleaning liquid from the flow rate control pipe 11 via the third tube (not shown). To the patient: CV port via a fourth tube (not shown), which has a wash inlet (not shown) for cleaning. At this time, if a flow rate control tube is used as a substitute for the flow rate control tube 11, it is possible to handle the second to third tubes with the flow rate control tube.

The flow rate control tube is a tube that adjusts the flow rate by friction due to the unevenness inside the tube, and by arbitrarily adjusting the length, the drug administration rate can be adjusted arbitrarily.
On the other hand, when the flow control tube 11 is used, it is not necessary to consider the handling of the tube, and the arrangement of the members can be performed stably, so that it is possible to reduce a wasteful space and it is possible to inject the pressurized drug injection excellent in portability. It becomes the vessel 1.

  The pressurized pharmaceutical injector 1 of the present invention has a configuration in which a tube from the chemical liquid outlet 8d to the downstream of the system cleaning port 12 in the above flow path is provided as one unit, and when system cleaning is performed by this configuration. No need to change the route for cleaning solution injection, such as removing the pressurized pharmaceutical injector 1 and Huber needle, or using other connection system, and it is convenient, and the user is exposed to the liquid medicine to the body. It can be prevented.

Next, in the flow path of FIG. 1B, the infusion filter 14 is integrated with the chemical liquid outlet 8d. In this case, the first tube becomes unnecessary, and the second tube directly communicates with the infusion filter 14 to the flow control tube 11, and further moves from the fourth tube to the patient via the CV port. With this configuration, the unit size and weight of the pressurized pharmaceutical injecting device 1 are reduced, and thus the portability is excellent.
In the flow channel of FIG. 1B, similar to the flow channel of FIG. 1A, if a flow rate control tube is used as a substitute for the flow rate control pipe 11, the flow rate control tube from the second tube to the third tube is used. It is also possible to deal with.

  A configuration without the infusion filter 14 as shown in FIG. 2A may be used. With this configuration, since the unit size of the pressurized pharmaceutical injecting device 1 is small and the weighing is performed, it is excellent in portability. In the flow path of FIG. 2 (a), a cleaning liquid injection port for introducing the cleaning liquid from the chemical liquid discharge port 8 d to the flow rate control pipe 11 via the first tube and from the flow rate control pipe 11 to the third tube is provided. It goes to the system wash port 12 that it has, and then from the fourth tube to the patient via the CV port. At this time, if a flow rate control tube is used as a substitute for the flow rate control tube 11, it is possible to handle the first to third tubes with the flow rate control tube.

  In the route of FIG. 2B, the chemical liquid outlet 8d, the infusion filter 14 and the flow rate control pipe 11 are integrated. The first tube and the second tube are no longer necessary, and the third tube directly communicates with the system cleaning port 12, and further moves to the patient: CV port through the fourth tube. With this configuration, the unit size and weight of the pressurized pharmaceutical injecting device 1 are small, and thus the portability is excellent.

  Further, the route of FIG. 3 is one in which the chemical liquid discharge port 8d, the infusion filter 14, the flow rate control pipe 11, and the system cleaning port 12 are integrated. The above-mentioned 1st tube, 2nd tube, and 3rd tube become unnecessary, and it moves to a patient: CV port through a 4th tube. With this configuration, the unit size and weight of the pressurized pharmaceutical injector 1 are reduced, which is advantageous in terms of portability.

  Even in the case of the main pressurization type drug injector 1 which employs the flow paths of FIGS. 1 (b), 2 (a), (b) and 3, the balloon is filled with the drug solution as in FIG. 1 (a). It can be said that at least a tube from the chemical liquid filling port to the chemical liquid discharge port 8d to the downstream of the system cleaning port 12 is provided as one unit.

  Next, a specific configuration example of the above-mentioned pressurized pharmaceutical injecting device 1 of the present invention will be described with reference to FIGS.

  4 and 5 are perspective views showing an embodiment of the pressurized drug injector 1 of the present invention. FIG. 5 shows a rear view (back side of the drawing) of FIG. The pressurized pharmaceutical injector 1 of the present invention shown in FIGS. 4 and 5 generally includes an outer case 2, an upper cover 4, a reservoir 8, a tube winding portion 10, a system cleaning port 12, an infusion filter 14, and FIG. It is composed of a chemical liquid connecting pipe 8d and a balloon 50 shown in FIG.

  The outer case 2 has a rectangular cross section in the z direction shown in the drawing having a r-shaped corner, and is formed in a so-called tapered shape that tapers from the lower end portion to the bottom surface. Therefore, it has a shape that has few corners as a whole and is safe and does not get caught when it is put in a pocket or the like of a patient's clothing. Similar to the outer case 2, the upper cover 4 is a rectangle having a r-shaped corner in the z-direction cross section, is provided with a top plate and is formed so that the lower side is opened, and the upper cover 4 covers the upper part of the outer case 2 and is connected thereto. Between the outer case 2 and the upper cover 4, a substantially flat top plate 6 that is an upper portion of the outer case 2 is arranged, and between the outer case 2 and the top plate 6 and the upper cover 4 and the top plate 6. Are each provided with a gap (space).

  The container composed of the outer case 2 and the upper cover 4 is made of a light material such as resin and has excellent portability. An elastic material is used in the examples of FIGS. 4 to 6 in order to prevent breakage or damage due to impact such as drop and external stress.

  On the top plate 6, a tube winding part 10, a reservoir 8 and a system cleaning port 12 are arranged substantially in series in the longitudinal direction of the top plate 6, and the upper and upper ends of the tube winding part 10, the reservoir 8 and the system cleaning port 12 are arranged. The cover 4 and the top plate are arranged so as not to interfere with each other. The top plate of the upper cover 4 is provided with substantially circular openings 4a and 4b, and the chemical liquid filling port 8a of the reservoir 8 and the system cleaning port port 12a of the system cleaning port 12 introduce the chemical liquid and the cleaning liquid. It may be fluidly connected to a medical syringe. Further, a substantially circular opening 4c for passing a tube for discharging the chemical liquid or the cleaning liquid to the outside is provided on a side portion of the upper cover 4 near the system cleaning port 12.

  With the above configuration, the pressurized pharmaceutical injector 1 can be easily accommodated in a pouch or bag, and can be administered while being put in a pocket of clothes, which makes it easy for a patient to carry. As will be described later in detail, in the pressurized pharmaceutical injection device 1, since the system cleaning port for introducing the cleaning liquid is inside the pressurized pharmaceutical injection device 1, it is necessary to perform the route switching operation of the chemical liquid to be injected into the system cleaning and the cleaning liquid. Therefore, cleaning is possible while avoiding exposure and infection due to unexpected liquid leakage.

  The reservoir 8 is integrally formed with the chemical liquid connecting pipe 8 d shown in FIG. 6, and penetrates the top plate 6 of the outer case 2. A liquid medicine filling port 8a is arranged on the upper side of the top plate 6 of the reservoir 8, and an opening 4a for connecting to the liquid medicine filling port 8a is formed in the upper cover 2.

On the other hand, a drug solution connecting pipe 8d integrally formed with the lower side reservoir 8 of the top plate 6 is arranged in the space between the outer case 2 and the top plate 6, and a balloon 50 is attached so as to cover it.
The material is preferably made of resin having a certain degree of elasticity to prevent easy damage when dropped. At the time of filling the drug solution, a drug solution (not shown) from a syringe (not shown) operated by a medical worker or under mechanical control is passed through the opening 4a of the upper cover 4 and the drug solution filling port 8a, and the drug solution connecting pipe 8d shown in FIG. Is injected into. Although not shown, since the check valve 8c is arranged between the drug solution filling port 8a and the reservoir column, there is no backflow to the drug solution filling port, and a dedicated screw-type plug (not shown) is attached to the drug solution filling port 8a.

  Further, although not shown, as another example of the liquid medicine filling port 8a, there is a screw hole that fits into the tip of a medical syringe for introducing the liquid medicine into the balloon 50. By rotating the tip of the medical syringe having a screw lock and fixing it to the liquid medicine filling port 8a by screw fitting while rotating, the influence of the reaction generated by the resistance of the liquid medicine between the liquid medicine filling port 8a and the medical syringe when the liquid medicine is filled Can be suppressed and separation can be prevented, and stable chemical liquid filling becomes possible.

  The opening 4a of the upper cover 4 is provided with a cap (not shown) that is removable by, for example, screw fitting. By removing the cap when introducing the drug and attaching the cap before and after introducing the drug, it is possible to prevent the contamination of the opening 4a before the drug filling operation and prevent the contamination (contamination) inside the pressurized drug injector 1 during the drug filling. However, when the medical syringe or the like is removed, the drug remaining in the opening can be sealed. The cap is preferably attached to the outer case 2 or the upper cover 2 with a strap or the like so as not to be lost during use.

  Here, the structure of the reservoir 8 will be further described with reference to FIG. 6. 6 shows a view of FIG. 4 taken along the line AA ′ (xz cross section), FIG. 6 (a) is a front view of the paper of FIG. 4, and FIG. 6 (b) is a view of the back of the paper. ing. As shown in FIG. 6, the reservoir 8 is integrally formed with a liquid medicine filling port 8a, a receiving portion 8b, a check valve 8c, a liquid medicine connecting pipe 8d, and a liquid medicine discharge passage 8 from the upper side. A medical worker connects the tip of a medical syringe or the like to the liquid medicine filling port 8a, applies positive pressure to allow the liquid medicine to pass through the check valve 8c, and fills the balloon 50 from the liquid medicine connecting pipe 8d with the balloon. The check valve 8c completely prevents the drug solution filled in the balloon 50 from flowing back to the drug solution filling port 8a, and the drug can be delivered to the drug solution discharge port 8.

The balloon 50 is arranged between the outer case 2 and the top plate 6, covers the drug solution connecting pipe 8d of the reservoir 8, and fixes the filled drug so that the drug is not leaked.
As the material of the balloon 50, resin rubber such as silicone rubber having elasticity and chemical resistance is used. When the balloon 50 is filled with the drug solution, the drug solution is deformed by pressure, and the drug solution can be pushed upward by the force action of returning the pressure deformation. As a result, the liquid medicine is delivered to the liquid medicine outlet 8e through the liquid medicine connecting pipe 8d.

  The dotted line display in FIG. 6 shows a state in which the balloon 50 is expanded by filling with the drug solution. The balloon 50 expands within the space range of the exterior case 2, and when contracted to the original size, the drug solution contained therein is pushed out above the balloon.

  In addition to the balloon, the pressurizing and deforming means may use a driving method such as a motor, an atmospheric pressure, or a spring.

  A first tube (not shown) is connected to the drug solution outlet 8e, is connected to an inlet 14a of the infusion filter 14, and a flow rate control tube (not shown) is connected to an outlet 14b of the infusion filter 14. ing. Since the flow rate control tube requires 5 to 10 cm, the tube is wound around the tube winding portion 10 having a substantially cylindrical shape so as not to be broken, and is connected to the inlet port 12C of the system cleaning port 12 and the discharge port 12d of the system cleaning port 12. The fourth tube is connected to, and the fourth tube comes out of the container from the drug solution discharge tube port 4C of the upper cover 4.

  The tube winding portion 10 is a lightweight resin that is easy to wind the flow control tube and has elasticity so that the tube is not crushed or broken, and it is preferable that the outer peripheral portion be provided with a spiral rounded groove.

  The infusion filter 14 is arranged near the inner side surface in the longitudinal direction of the upper cover 4. A general shape is adopted, and a substantially circular shape is shown in FIGS. The infusion filter 14 is used because it filters the drug solution, and when foreign substances, large particle diameters, and air are mixed in the filled drug solution, it is possible to prevent mixing into the patient and blockage of the flow rate control tube 11 and the flow rate control tube. Preferably.

  In the configuration from the chemical liquid outlet 8d to the port inlet 12b, as another example not shown, there is a configuration in which the chemical liquid outlet 8d and the port inlet 12b are connected by a flow control pipe 11. According to this configuration, it is possible to directly connect the chemical liquid discharge port 8d and the port inlet 12b to the flow rate control pipe 11 without using a tube, and since the tube is not used, the required space becomes smaller, so The overall size of the pressure-type pharmaceutical injector 1 can be further reduced. Here, the flow rate control tube means a tube capable of controlling the flow rate by inserting a resistance device such as unevenness or a filter into the tube. Further, if the infusion filter 14 is provided in the flow rate control tube, the size of the pressurized pharmaceutical injecting device 1 can be made more compact, and foreign substances and large particle diameters can be prevented from entering the patient.

  As another example not shown, the opening 4b of the upper cover 4 may be provided with a removable sealing member. The sealing member is sealed from the outside so as to cover the opening 4b, and by removing the sealing member at the time of introducing the cleaning liquid, it is possible to look into the cleaning liquid introducing portion 12a from the opening 4b and the opening 4b. As a result, it is possible to prevent contamination (contamination) around the cleaning liquid introducing portion 12a and keep the flash port 12 clean until the system is cleaned. In addition to the opening 4b, the cleaning liquid introducing part 12a, the opening 4b, and the cleaning liquid introducing part 12a may be sealed by a sealing member. In addition to the sealing member, the cap member described above may be employed as necessary.

  Further, in the system cleaning port 12, as in the case of the reservoir 8 described above, the upper portion of the cleaning liquid introducing portion 12a at the upper end of the system cleaning port 12 and the opening 4b of the top plate of the upper cover 4 are separated from each other. With this configuration, it is possible to prevent the chemical liquid or the cleaning liquid from leaking to the outside of the pressurized pharmaceutical injector 1 even if an erroneous operation occurs when the chemical liquid or the cleaning liquid is introduced, or even if the opening 4b faces the ground. Is.

  Further, the upper cover 4 also increases the effect of mitigating direct impact on the reservoir 8 and the system cleaning port 12.

  Although the pressurized pharmaceutical injector 1 of the present invention has been described above with reference to FIGS. 4 to 6, the design may be changed to be suitable for use in the medical field. For example, the first tube may be connected to the flow rate control tube 11 and eliminated from the second tube by removing the filter 14 to improve portability. Further, the filter 14 may be provided integrally with the reservoir 8. Further, it is possible to make the entire shape of the pressurized pharmaceutical injector 1 into a flatter shape or an elongated shape in accordance with the place to be placed.

  Further, as still another example, the arrangement of the cleaning liquid introducing portion 12a of the system cleaning port 12 is provided, for example, in the outer case 2 and the opening is provided in the outer case 2 to separate the cleaning liquid introducing portion 12a from the chemical liquid filling port 8a. It may be possible to reduce the size and weight by placing it in a different place. In addition, in order to maintain the sanitary condition of the port opening 12a of the system cleaning port 12, a method of arranging the system cleaning port 12 including the port opening 12a in a substantially closed space can be considered.

  In the conventional pressurized pharmaceutical injecting device, it is necessary to switch the tube connection or the like for injecting the cleaning liquid when cleaning the system, and there is a risk of exposure to the medical liquid or infection. As described above, the pressurized pharmaceutical injector 1 of the present invention is provided with the system cleaning port 12 in the substantially enclosed space formed by the outer case 2 and the upper cover 4, and by this configuration, the tube connection, etc. There is no need to switch between the two, and it is possible to fill the chemical liquid and inject the cleaning liquid as a single unit that includes all tubes, filters, and the like. The tube winding unit 10 enables a tube of an arbitrary length to be densely arranged in a fixed space without damage.

  Although the pressurized pharmaceutical injector 1 of the present invention has been described above, the arrangement shape and size of the members are suitable for use as medicines and medical devices, and are in a general range for coping with medical care that is evolving day by day. Needless to say, it is possible to modify in.

2 Outer case 4 Upper cover 6 Top plate 8 Reservoir 8d Drug connection pipe 10 Tube winding part 12 System cleaning port 14 Infusion filter 50 Balloon

Claims (5)

A pressurized pharmaceutical injector having a system cleaning function, a reservoir having a liquid medicine filling port and a liquid medicine discharge port, and pressure deforming means for pushing out the liquid medicine by a force that is deformed under pressure by the liquid medicine filling and the pressure deformation returns. A case including a flow rate control tube for adjusting a flow rate and a system cleaning port for injecting a cleaning solution is provided.
The case, in the vicinity of the chemical filling port, the chemical discharge port, the cleaning liquid injection port,
Each has an opening, and the chemical liquid injected from the chemical liquid filling port is filled in the pressurizing and deforming means, and the flow rate is adjusted by the pressure from the chemical liquid discharging port through the communicating means by the flow rate control pipe. And passes through the system cleaning port through the communication means and moves to the outside,
A pressurized pharmaceutical injector characterized in that   The pressurizing pharmaceutical injection device according to claim 1, wherein the communication means of the reservoir between the drug solution discharge port and the drug solution fill port controls the flow rate.   The said chemical | medical solution filling port and the said washing | cleaning liquid filling port have the screw hole which engages with the front-end | tip of the syringe for introduce | transducing a chemical | medical solution and a washing | cleaning liquid inside, The claim 1 or 2 characterized by the above-mentioned. Pressurized drug injector.   The pressurized pharmaceutical injection according to any one of claims 1 to 3, wherein an opening near the filling of the cleaning liquid injection port of the case is sealed by a removable sealing member to ensure a sterilized state. vessel   The pressurized pharmaceutical injection device according to any one of claims 1 to 4, wherein the communication means is provided with a filter that suppresses passage of particles having a predetermined diameter or longer.