JP2019041696A - Oral composition - Google Patents

Abstract

To provide a placenta extract and/or collagen peptide-containing oral composition and a method for producing the same in which the unique odor and taste of the placenta extract and/or collagen peptide are masked.SOLUTION: Provided is an oral composition containing (A) to (C): (A) placenta extract and/or collagen peptide; (B) linalool; (C) γ-decalactone. The oral composition of the present invention is preferably used as a beverage, and preferably contains linalool by 0.1 to 1.2 ppm and γ-decalactone by 0.5 to 10 ppm.SELECTED DRAWING: None

Description

  The present invention relates to an oral composition in which the unique odor and taste of placenta extract and / or collagen peptide are masked.

  Placenta extract is actively used in the fields of beauty, health or medicine. For example, an oral composition characterized by containing a placenta extract, a collagen-derived component and a stress relieving agent (Patent Document 1), an intestinal environment improving composition characterized by a combination of oligosaccharide and placenta extract (Patent Document) 2) A health comprising a nerve cell activator containing a placenta extract (Patent Document 3), a collagen hydrolyzate, a porcine placenta extract, a low molecular weight polyphenol derived from lychee, and ascorbic acids as cosmetic ingredients. Food (patent document 4) etc. are known.

  However, the placenta extract has a peculiar unpleasant taste and smell when taken orally because its origin is a living organism, and masking them has been a problem.

  Collagen peptides are collagens and gelatins extracted from animals and fish that have been reduced in molecular weight by hydrolysis, and are known for their beauty effects and joint strengthening effects. In the past, many products formulated into tablets, granules, capsules, powders, beverages, etc. have been put on the market in anticipation of the above-mentioned effects of collagen peptides.

  In order to obtain the effect of the collagen peptide, it is necessary to continuously ingest the collagen peptide. For this purpose, a drink form that can be easily ingested is preferable. However, there is a problem that beverages containing collagen peptides have a raw odor that is felt by smell. Moreover, when a low molecular weight collagen peptide is mix | blended, the bitter taste derived from the amino acid contained as an impurity may be exhibited.

  Regarding beverages containing collagen peptides having an unpleasant odor in this way, for example, Patent Document 5 discloses beverages containing various nutrients including collagen hydrolysates, and two or more extracts and sour agents containing barley extract and the like. In addition, a technology for realizing a healthy beverage having a good flavor by using a fruit flavor or the like is disclosed.

  Patent Document 6 describes masking the fish odor of a jelly drink containing a fish-derived collagen peptide using indigestible dextrin, and Patent Document 7 describes the taste of a food or drink containing a collagen peptide, sucralose and It is disclosed to improve by formulating stevia extract.

  However, the conventional masking of the raw odor of foods and drinks containing collagen peptides is not sufficient, and there is room for improvement, particularly in terms of merchantability.

JP 2007-70316 A JP 2011-157335 A JP 2012-136448 A JP 2013-34423 A JP-A-5-199855 JP 2006-180812 A JP 2006-204287 A

  This invention makes it a subject to provide the placenta extract and / or collagen peptide containing oral composition which masked the unique smell and taste which a placenta extract and / or collagen peptide have, and its manufacturing method.

(1)
An oral composition containing (A) to (C) is provided.
(A) Placenta extract and / or collagen peptide (B) linalool (C) γ-decalactone

(2)
The oral composition according to claim 1, which is a beverage.

(3)
The oral composition according to claim 1 or claim 2 containing 0.1 to 1.2 ppm of linalool.

(4)
The oral composition according to claim 1, which contains 0.5 to 10 ppm of γ-decalactone.

  The oral composition of the present invention exhibits the effect of masking the unique odor and taste of the placenta extract and / or collagen peptide by using linalool and γ-decalactone in combination.

  Hereinafter, modes for carrying out the present invention will be described.

  The oral composition of the present invention contains a placenta extract and / or a collagen peptide.

  The origin of the placenta from which the placenta extract is obtained is not particularly limited, and examples thereof include humans, cows, horses, pigs, sheep, goats, salmon, herring, sturgeon, roses, and melons. Among these sources, it is preferable to use those derived from pigs from the viewpoint of commercial use. Moreover, there is a product already marketed as a placenta extract, and it may be used.

  An example of a method for producing placenta extract is a method of treating pig placenta with a protease. Examples of the protease include papain, trypsin, pepsin, promeline, thermolysin and the like. Of these, papain is preferably used from the viewpoint of protease treatment efficiency. The protease treatment proceeds by reacting at about 3 to 75 ° C. for about 0.5 to 3 hours. The components obtained by the protease treatment are centrifuged, ultrafiltered, diatomaceous earth filtered, ion exchange resin, reverse osmosis filtered. The placenta extract can be obtained by purification by activated carbon treatment or the like.

  The above placenta extract can be pulverized by conventional means such as spray drying and freeze drying.

  The content of the placenta extract is 0.01 to 20 g, more preferably 0.1 to 10 g as an intake amount per time. Ingestion of less than 0.01 g may not exhibit the effect of placenta extract. Moreover, even if it takes more than 20g, the effect may not be recognized, but it is inefficient.

  The collagen peptide used in the present invention is gelatin obtained by heating and denaturing collagen, which is a protein that is abundant in animal bones and skins, and collagen peptide obtained by further hydrolyzing it with acid, alkali or enzyme. Say. In the present invention, collagen can be used without any particular limitation with respect to derived organisms (pigs, cows, fish, etc.) and production methods (acid treatment, alkali treatment, etc.). For example, as animals, bones and skins of animals such as cows, pigs and chickens, and fish skins and scales such as salmon, tuna, tilapia and cod can be used.

  The weight average molecular weight of the collagen peptide used in the present invention is in the range of 100 to 200000, preferably 100 to 5000, more preferably 500 to 5000, and most preferably 1000 to 4000. In the case of a collagen peptide having a weight average molecular weight of more than 20000, the odor derived from the raw material is strong and the effects of the present invention may not be exhibited. In the case of a collagen peptide having an average molecular weight of less than 100, the influence on amino acid-derived taste is increased, and the effects of the present invention may not be exhibited.

  The compounding amount of the collagen peptide in the oral composition of the present invention is preferably 50 mg to 10000 mg as a single intake. If the formulation is less than 50 mg, the effect of ingesting collagen is unlikely to be expected.

  The oral composition of the present invention contains linalool and γ-decalactone.

  The method of blending linalool and γ-decalactone into the oral composition may be blended with linalool and γ-decalactone itself, or may be blended as an essential oil or flavor containing linalool and / or γ-decalactone.

  Examples of essential oils containing linalool include rosewood, linaloe, mellow, neroli, lavender, bergamot, clarisage, coriander and the like. Among these essential oils, it is most preferable to use coriander from the viewpoint of odor masking effect.

  Examples of flavors containing linalool include rosewood-like flavors, linaloe-like flavors, neroli-like flavors, lavender-like flavors, bergamot-like flavors, clarisage-like flavors, and coriander-like flavors. Among these essential oils, it is most preferable to use a coriander-like flavor in terms of odor masking effect. Among these essential oils, it is most preferable to use a coriander-like flavor in terms of odor masking effect.

The blending amount of linalool into the oral composition varies depending on the dosage form of the oral composition, the placenta extract and / or the collagen peptide, but preferably 0.1 to 1 with respect to the total amount of the oral composition. .2 ppm is preferred.

  Examples of the essential oil containing γ-decalactone include Kanagi cocoon, peach, plum, apricot, mango and the like. Among these essential oils, it is most preferable to use one or two selected from peach mango from the viewpoint of the odor masking effect.

  Examples of flavors containing γ-decalactone include Kanagi-sama-like flavors, peach-like flavors, mango-like flavors, plum-like flavors, and apricot-like flavors. Among these essential oils, it is most preferable to use one or two kinds selected from a peach-like flavor and a mango-like flavor in terms of the odor masking effect.

  The amount of γ-decalactone to be added to the oral composition varies depending on the dosage form of the oral composition, the amount of placenta extract and / or collagen peptide, but preferably 0.5% relative to the total amount of the oral composition. It is preferable to set it to -10 ppm.

  The oral composition of the present invention may be used in any dosage form, but exhibits good effects in beverages, orally disintegrating tablets, gums, and granules in terms of ease of taste of placenta extract and / or collagen peptide. In particular, it is effective in the field of beverages. In the present invention, the beverage includes not only a so-called drink beverage having a low viscosity but also a jelly agent having a high viscosity.

  In the case of a beverage, it is preferable to adjust the pH to 5 or less, particularly to 2 to 4.

  As such a pH adjuster, organic and inorganic edible acids can be used. The acids may be used in their undissociated form or in the form of their respective salts, such as potassium or sodium hydrogen phosphate, potassium dihydrogen phosphate or sodium salt. Preferred acids are edible acids including citric acid, malic acid, fumaric acid, adipic acid, phosphoric acid, gluconic acid, tartaric acid, phytic acid, ascorbic acid, acetic acid, phosphoric acid or mixtures thereof. Bicarbonates can also be used.

  In order to produce the oral composition according to the present invention as a beverage whose pH is adjusted in this way, the beverage is preferably produced in a container form. There are no particular restrictions on the type of container, but any container such as a molded container (so-called PET bottle) mainly composed of polyethylene terephthalate, a metal can, a paper container combined with a metal foil or plastic film, or a bottle should be used. Can do.

  Furthermore, in order to improve palatability, you may select and mix | blend a sweetener suitably. For example, carbohydrates such as sucrose, glucose, and maltose, high-intensity sweeteners such as stevia, aspartame, thaumatin, and acesulfame K, sugar alcohols such as sorbitol, erythritol, and xylitol, and glycerols such as glycerin can be used. .

  In the preparation of the oral composition of the present invention, special additives such as surfactants are not essential, but other known additives, excipients, etc. may be added to an appropriate dosage form as necessary. And may be processed. For example, in the case of a liquid agent, an antioxidant, a colorant, a flavoring agent, a surfactant, a plasticizer, a pH adjuster, etc. can be mixed to obtain an oral product such as a dry syrup agent or a liquid agent. If it is a solid agent, an excipient, a disintegrant, a binder, a lubricant, an antioxidant, a coating agent, a coloring agent, a corrigent, a surfactant, a plasticizer, etc. are mixed in a conventional manner. Granules, powders, capsules, tablets and the like can be produced.

  Examples of the antioxidant include vitamin C, dibutylhydroxytoluene (BHT), propyl gallate, butylhydroxyanisole (BHT), α-tocopherol, and citric acid.

  Examples of the colorant include caramel, safflower dye, silicon dye, turmeric dye, and tar dye.

  Examples of the surfactant include polyglycerin fatty acid ester, polyoxyethylene hydrogenated castor oil, sorbitan fatty acid ester, polyoxyethylene polyoxypropylene block copolymer, polysorbate, sodium lauryl sulfate, macrogol, and sucrose fatty acid ester. It is done.

  In addition to the placenta extract and collagen peptide, various physiologically active ingredients can be blended as necessary. Examples of such physiologically active ingredients include proteins and hydrolysates thereof, peptides, amino acids, vitamins, polysaccharides, oligosaccharides, plant extracts, crude drugs and the like.

  In order to give palatability to the oral composition of the present invention, various fragrances other than linalool and γ-decalactone may be added.

  EXAMPLES Hereinafter, the present invention will be specifically described with reference to examples, but the scope of the present invention is not limited thereby.

[Aroma evaluation method]
Seven panelists specializing in flavor evaluation evaluated the intensity of placenta fragrance using blind VAS.

[Taste evaluation method]
Seven analyst-type evaluation panelists who perform expiry date evaluation etc. evaluated the strength of placenta taste using blind VAS.

  Using the formulation shown in Table 1, a predetermined amount of flavor described in Table 2 was added, and a beverage was prepared by a conventional method.

[Placenta extract]
The placenta extract obtained by subjecting the placenta obtained from SPF pig (Specific Pathogen Free Pig) to blood removal and washing using purified tissue was freeze-dried and dispersed in 1/9 amount of dextrin. Was used as placenta extract.

[Collagen peptide]
A commercially available fish skin and scale-derived collagen peptide having a weight average molecular weight of about 3000 was used.

  The beverage of Example 1 blended with decalactone and linalool was synergistically reduced in both aroma and taste compared to the beverages of Comparative Example 3 and Comparative Example 6 blended with decalactone and linalool, respectively. . In contrast, the beverage of Comparative Example 10 in which decalactone and menthol were used in combination showed an increase in the scent score as compared to the beverages of Comparative Example 3 and Comparative Example 4 each containing a single formulation, and the balance of fragrance and taste was lost. It was.

[Example 2] Beverages
(1) Flavor mixture 110mg
(2) Collagen 550mg
(3) Amount to make citric acid pH 3.5
(4) Sweetener Amount to make Brix value 7.0
(5) Purified water Amount to bring the total amount to 50 mL When the beverage mixture was 50 mL, a flavor having a linalool content of 0.98 ppm and a γ-decalactone content of 3.5 ppm was used.

[Example 3]
Beverage
(1) Flavor mixture 344mg
(2) Placenta extract 40mg
(3) Collagen 100mg
(4) Citric acid Amount to adjust pH to 2.4
(5) Sweetener Amount to bring Brix value to 7.0
(6) Purified water Amount to bring the total amount to 140 mL When the beverage mixture was 140 mL, a flavor having a linalool content of 0.14 ppm and a γ-decalactone content of 4.25 ppm was used.

[Example 4]
Beverage
(1) Flavor mixture 215mg
(2) Placenta extract 100mg
(3) Collagen 160mg
(4) Amount that makes citric acid pH 3.5
(5) Sweetener Amount to bring Brix value to 7.0
(6) Purified water Amount to make the total amount 100 mL When the beverage mixture was 100 mL, a flavor having a linalool content of 0.74 ppm and a γ-decalactone content of 3.5 ppm was used.

[Example 5]
Beverage
(1) Flavor mixture 215mg
(2) Placenta extract 100mg
(3) Collagen 160mg
(4) Amount that makes citric acid pH 3.5
(5) Sweetener Amount to bring Brix value to 7.0
(6) Purified water Amount to bring the total amount to 150 mL When the beverage mixture was 145 mL, a flavor having a linalool content of 0.74 ppm and a γ-decalactone content of 3.5 ppm was used.

  The beverages according to Examples 2 to 5 were beverages having a good taste without being concerned about the raw smell of placenta extract or collagen.

Claims (4)

An oral composition containing (A) to (C).
(A) Placenta extract and / or collagen peptide (B) linalool (C) γ-decalactone   It is a drink, The composition for oral administration of Claim 1 characterized by the above-mentioned.   The composition for oral administration according to claim 1 or 2, comprising 0.1 to 1.2 ppm of linalool.   The composition for oral administration according to one of claims 1 to 3, containing 0.5 to 10 ppm of γ-decalactone.