JP2019031458A - How to stop blood-sucking pests - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a method for promptly stopping the movement of a blood-sucking pest in order to enhance the extermination effect of the pest. SOLUTION: A composition containing a siloxane compound as an active ingredient and having a contact angle with respect to a glass surface adjusted to 31 degrees or less is applied to a blood-sucking pest or a place where a blood-sucking pest is infested. It is a method of stopping the action. [Selection diagram] None

Description

  The present invention relates to a method for stopping the behavior of blood-sucking pests, and more particularly to a method for stopping behavior such as walking in order to control the blood-sucking pests.

  Human lice and head lice such as head lice and body lice are known as lice parasitic on humans. Among them, head lice infection has been increasing in recent years, and children, children, etc. are severely damaged by group life, and infection to their families has also been reported. When a head lice sucks blood, it not only causes itching, but also may cause infection from trauma, swelling of the lymph nodes, fever, and the like.

  In addition, bed bug damage has increased in recent years, and bed bugs attached to bags and clothing at the travel destination can be taken home from the travel destination or brought in from imported furniture, etc. You may suffer from blood sucking damage. It is known that bed bugs crawl out at night, perform blood-sucking behavior, and lay eggs every day, causing damage to bed bugs.

  As fleas counted as blood-sucking pests like lice, dog fleas and cat fleas that are parasitic on dogs and cats are known. If adults of dog fleas and cat fleas parasitize pet animals such as dogs and cats, they not only cause pet dermatitis and anemia, but also cause biting damage to the owner, causing redness and rash, etc. May cause allergies such as atopic dermatitis.

  As a method for controlling such blood-sucking pests, a method of washing hair and body hair using a shampoo containing a pyrethroid insecticide as an active ingredient, or a skin external preparation containing the active ingredient is applied to the skin. The method of administration is generally made.

  The shampoo composition for controlling lice comprises, for example, 1) an amine oxide having a specific structure, 2) a polyoxyethylene polyoxypropylene block polymer, and 3) a polyoxyethylene sorbitan fatty acid ester and / or a polyoxyethylene alkylphenyl ether. A shampoo composition containing a nonionic surfactant and 3-phenoxybenzyl-d-cis-transcrisantemate as a medicinal component (Patent Document 1), pyriproxyfen 0.001 to 5% by weight, anionic A shampoo composition (Patent Document 2) containing 10 to 70% by weight of a surfactant and 0.5 to 20% by weight of a polyhydric alcohol has been proposed.

  Moreover, as an external preparation for skin, for example, an animal ectoparasite control composition comprising an O / W emulsion containing phenothrin has been proposed (Patent Document 3).

JP-A-6-298628 Japanese Patent Laid-Open No. 10-81616 JP 2012-102033 A

  However, although the conventional disinfecting composition can be expected to have an insecticidal effect against blood-sucking pests, especially lice move quickly, so that the active ingredient in the disinfecting composition is sucked or escaped before a sufficient amount of the active ingredient acts. Problems such as failure to obtain the effect sometimes occurred.

  This invention is made | formed in view of the said subject, Comprising: In order to improve the extermination effect of a blood-sucking pest, the method of stopping this pest's movement rapidly is provided.

  As a result of intensive research, the present inventor has found that the siloxane compound acts effectively in order to quickly stop the action of the blood-sucking pest, and that the contact angle of the disinfecting composition is adjusted to a specific range. Thus, the inventors have found that the time required to stop the action when treating a blood-sucking pest can be shortened, and the present invention has been completed.

That is, the said subject is solved by following structure (1)-(5).
(1) A composition containing a siloxane compound as an active ingredient and having a contact angle with respect to a glass surface adjusted to 31 degrees or less is applied to a blood-sucking pest or a place where a blood-sucking pest is parasitic. To stop the behavior of blood-sucking pests.
(2) The method for stopping the action of blood-sucking pests according to (1), wherein the composition further contains a fatty acid ester.
(3) The siloxane compound is at least one selected from the group consisting of dimethylpolysiloxane, decamethylcyclopentasiloxane, methylphenylpolysiloxane, amino-modified silicone and polyether-modified silicone. The method for stopping the action of blood-sucking pests according to 1) or (2).
(4) The blood-sucking pest behavior stopping method according to any one of (1) to (3), wherein the siloxane compound contains dimethylpolysiloxane.
(5) Any of the above (1) to (4), wherein the blood-sucking pest is at least one selected from the group consisting of a chewing jaw pest, a receptive pest, and a hemipod pest The method of stopping the action of the blood-sucking pest according to any one of the above.

  According to the method for stopping the behavior of a blood-sucking pest of the present invention, the behavior of the blood-sucking pest can be stopped quickly (specifically, within 2 minutes). Therefore, it is possible to suppress the blood-sucking pests from sucking blood, prevent the movement and escape of the blood-sucking pests, and prevent the spread of the pest damage, effectively acting the active ingredient And can control blood-sucking pests.

  Hereinafter, the present invention will be described in more detail.

  The present invention is made by paying attention to the active ingredient of the composition for combating used and the physical properties (specifically, the contact angle) of the composition itself, and the behavior of the blood-sucking pest of the present invention The stopping method is characterized in that the contact angle with respect to the glass surface is adjusted to 31 degrees or less for a composition containing a siloxane compound as an active ingredient. As a result, when the composition is treated against a blood-sucking pest, the permeability of the composition to the blood-sucking pest increases, and the action of the blood-sucking pest can be stopped in a short time of 2 minutes or less. is there.

  The blood-sucking pests to be treated in the present invention are parasites that suck blood and body fluids for survival.For example, chin-eye pests such as head lice, white lice, leaf lice, white lice, and dog lice, cat fleas, dog fleas, human fleas And the like, and Hemiptera pests such as bed bugs. The method for stopping the action of blood-sucking pests according to the present invention can target adults and larvae of at least one of these pests.

As described above, the composition used in the method for stopping the action of the blood-sucking pest of the present invention (hereinafter also referred to as “control composition”) contains a siloxane compound as an active ingredient.
The siloxane compound has a Si—O bond in the main chain and an organic group such as an alkyl group in the side chain. The reason why the action of blood-sucking pests can be stopped by the siloxane compound is not clear, but the siloxane compound quickly penetrates the blood-sucking pests into the body surface and body section, and acts to block movement and form a film on the whole body surface. Therefore, it is considered to have an action of blocking movement, and as a result, it is considered that the action of blood sucking pests such as walking and blood sucking action is stopped.

  Examples of the siloxane compound include chain polysiloxanes such as dimethylpolysiloxane, methylphenylpolysiloxane, and diphenylpolysiloxane; cyclic polysiloxanes such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, and dodecamethylcyclohexasiloxane; amino Examples thereof include modified silicones such as modified silicone, polyether-modified silicone, and polyglycerin-modified silicone; siloxane compound copolymers. These may be used individually by 1 type, or may be used in combination of 2 or more type. Among them, it is preferable to use at least one selected from the group consisting of dimethylpolysiloxane, decamethylcyclopentasiloxane, methylphenylpolysiloxane, amino-modified silicone, and polyether-modified silicone, and particularly includes dimethylpolysiloxane. It is preferable.

  The content of the siloxane compound in the disinfecting composition is preferably 40% by mass or more. It is preferable that the content of the siloxane compound is 40% by mass or more because an effect of stopping behavior against blood-sucking pests can be obtained. 60 mass% or more is more preferable, and, as for content of a siloxane compound, 70 mass% or more is still more preferable. Further, the upper limit of the content of the siloxane compound is not particularly limited, and may be composed of only the siloxane compound (that is, the content is 100% by mass) if the contact angle of the disinfecting composition is 31 degrees or less, It is preferably 95% by mass or less, more preferably 85% by mass or less, and still more preferably 80% by mass or less.

  The disinfecting composition can contain various components that are pharmacologically acceptable to the human body as other components. Examples of other components include insecticide components, solvents, surfactants, fragrances, and pigments.

  As the insecticidal component, fatty acid esters can be suitably used in the present invention. Fatty acid esters have an insecticidal effect against blood-sucking pests, including adult lice and larvae, for unclear reasons. Inclusion in a composition for disinfecting enhances the insecticidal effect against blood-sucking pests. it can.

  The fatty acid ester used in the present invention is a fatty acid ester containing a fatty acid residue and an alcohol residue, both of the fatty acid residue and the alcohol residue have a branched structure, and carbon of the alcohol residue. It is preferable that it is a fatty acid ester whose number is larger than the carbon number of the fatty acid residue. The number of carbon atoms of the alcohol residue in the fatty acid ester may be larger than the number of carbon atoms of the fatty acid residue. Specifically, the ratio of the carbon number of the alcohol residue to the carbon number of the fatty acid residue in the fatty acid ester is 1.1. The above is preferable. Moreover, the number of carbon atoms of the alcohol residue is more preferably about 1 to 10 greater than that of the fatty acid residue. The number of carbon atoms of the fatty acid residue in the fatty acid ester is preferably 7 to 13, and more preferably 8 to 9. In the fatty acid ester, in each of the fatty acid residue and the alcohol residue, the second carbon atom from the terminal is preferably a secondary carbon atom or a tertiary carbon atom.

  Specific examples of the fatty acid ester include, for example, isodecyl isononanoate, isotridecyl isononanoate, 2-hexyldecyl 2-ethylhexanoate, etc., and these may be used alone or in combination of two or more. . Among these, isotridecyl isononanoate and 2-hexyldecyl 2-ethylhexanoate are preferable because of their high insecticidal effect against blood-sucking pests. Furthermore, isotridecyl isononanoate is particularly preferable because it is difficult to solidify even at low temperatures and has excellent storage stability for a long period of time.

  Although content of fatty acid ester is not specifically limited unless the effect of this invention is prevented, For example, it is preferable that it is 4-80 mass% in the composition for extermination, and 5-30 mass% is more preferable.

  As other insecticidal components, insecticides belonging to pyrethroid compounds, carbamate compounds, organophosphorus compounds, neonicotinoid compounds, and the like can be used. Among these, it is preferable to use a pyrethroid compound from the viewpoint of safety.

  Examples of pyrethroid compounds include acrinatrin, allethrin, d-areslin, dd-areslin, cyfluthrin, beta-cyfluthrin, bifenthrin, cycloprotorin, cyhalothrin, cypermethrin, dimethylfluthrin, empentrin, deltamethrin, terrareslin, tefenthrate, esfenvalerate. , Etofenprox, fenpropatrin, fenvalerate, flucitrinate, flufenprox, flumethrin, fulvalinate, profluthrin, halfenprox, imiprotolin, permethrin, benfluthrin, praretrin, pyrethrin, resmethrin, d-resmethrin, sigma-cypermethrin , Silafluophene, tefluthrin, tralomethrin, transfluthrin, tetra Trindade, d- tetramethrin, phenothrin, d- phenothrin, cyphenothrin, alpha-cypermethrin, zeta-cypermethrin, lambda cyhalothrin, cancer better halo Trindade, furamethrin, tau full Bali sulfonate, Metofluthrin, natural pyrethrins, and the like.

  Examples of carbamate compounds include alanicarb, bendiocarb, benfuracarb, BPMC, carbaryl, carbofuran, carbosulfan, cloetocarb, etiofencarb, fenobucarb, phenothiocarb, phenoxycarb, furthiocarb, isoprocarb, metocarb, mesomil, oxathiocarb, N , Pyrimicarb, propoxyl, XMC, thiodicarb, xylylcarb, aldicarb and the like.

  Examples of organophosphorus compounds include acephate, aluminum phosphide, butathiophos, cadosaphos, chlorethoxyphos, chlorfenbinphos, chlorpyrifos, chlorpyrifosmethyl, cyanophos, diazinon, DCIP, diclofenthion, dichlorvos, dimethoate, dimethylvinphos, disulfoton , EPN, ethion, ethoprophos, etrimphos, fenthion, fenitrothion, phosthiazete, formothione, hydrogen phosphide, isofenphos, isoxathione, malathion, mesulfenphos, methidathion, monocrotophos, nared, oxydeprophos, parathion, hosalon, phosmet, pyrimiphosmethyl, pyridafenthione Quinalphos, Fentoate, Profenofos, Propafos, Prothiofo , Pyraclofos, salithion, sulprofos, tebupirimfos, temephos, tetrachlorvinphos, terbufos, thiometon, trichlorfon, vamidothion, folate, cadusafos, and the like.

  Examples of neonicotinoid compounds include imidacloprid, nitenpyram, acetamiprid, thiamethoxam, thiacloprid, dinotefuran, clothianidin and the like.

  The solvent can be contained in order to dissolve each component in the disinfecting composition or to adjust the contact angle of the composition. Examples of the solvent include water, water-soluble solvents (such as glycerin), alcohol solvents (such as methanol and ethanol), and hydrocarbon solvents (such as liquid paraffin).

  Surfactants can be included to enhance detergency in rinsing after treatment with the disinfectant composition. By containing a surfactant in the disinfecting composition, it becomes easy to wash out the disinfecting composition after the treatment. Examples of the surfactant include polysorbate, polyoxyethylene tetraoleate (POE) sorbit, and polyethylene glycol diisostearate (PEG).

  A fragrance | flavor can be contained for the purpose of the provision of the fragrance for the provision of the fragrance to the composition for extermination, and a feeling of use at the time of a process. By containing a fragrance, the feeling of use effect can be enhanced. Examples of fragrances include natural fragrances such as potato, bergamot oil, cinnamon oil, citronella oil, lemon oil, lemongrass oil, pinene, limonene, linalool, menthol, borneol, eugenol, citral, citronellal, heliotopin, crocodile, etc. Examples include artificial flavors.

  A pigment | dye can be contained for the external appearance improvement of the composition for extermination. Examples of the dye include legal dyes such as nitro dyes, azo dyes, nitroso dyes, triphenylmethane dyes, quinoline dyes, anthraquinone dyes, and indigo dyes. Among these, water-soluble ones are preferable.

  The disinfecting composition can be prepared by mixing only the siloxane compound or the siloxane compound and other optional components.

  The disinfecting composition is in a liquid form, and in the present invention, it is important that the contact angle of the disinfecting composition with respect to the glass surface is 31 degrees or less. If the contact angle to the glass surface of the disinfectant composition is 31 degrees or less, the penetrability of hair-absorbing pests and the like will increase and spread quickly over a wide area. The contact with the blood-sucking pest is made, and the time until the action of the blood-sucking pest is stopped can be shortened. The contact angle is preferably 30 degrees or less, and the lower limit thereof is not particularly limited, but is preferably 3 degrees or more.

  The contact angle can be measured using a commercially available contact angle meter. For example, using a FACE contact angle meter CA-X type manufactured by Kyowa Interface Science Co., Ltd., a predetermined amount of the composition for disinfecting the slide glass. It can be measured by measuring the contact angle to the glass surface when an object is dropped.

  In the present invention, the method for setting the contact angle to the glass surface of the disinfecting composition to 31 degrees or less can be carried out by a conventionally known method. For example, the content of the siloxane compound is adjusted, and if necessary, the solvent The contact angle may be adjusted using, for example. Examples of the solvent to be added include alcohol solvents such as ethanol and isopropanol, hydrocarbon solvents such as liquid paraffin having a polymerization degree of less than 40, and fatty acid esters such as isotridecyl isononanoate and isopropyl myristate. As for the siloxane compound to be used, the contact angle with respect to the glass surface can be reduced to 31 degrees or less by using a siloxane compound having a polymerization degree of low to medium less than 150. The contact angle can also be adjusted by blending an appropriate amount of fumed silica such as hydrophilic silica used as an oily feel imparting agent or a dextrin fatty acid ester such as dextrin palmitate.

As a method of applying the disinfectant composition to the object to be treated, an effective amount of the disinfectant composition is directly applied to the blood-sucking pest or an effective amount of the disinfectant composition is applied to a place where the blood-sucking pest is parasitic. To do. Specific examples include a method of applying about 0.8 to 100 mL of the disinfectant composition per 100 cm ² of the target surface by dropping, coating, spraying, dipping, or the like. For example, when treating hair, it is only necessary to drop, apply, spray, etc. the composition for controlling the blood-sucking pest directly or to the place where the blood-sucking pest is parasitic. For example, the disinfecting composition may be stored in a container and the cloth may be immersed therein. After application, it is allowed to stand for several seconds to 5 minutes to wash away the disinfecting composition.

  As described above, by applying an effective amount of the composition for controlling the present invention to a blood-sucking pest or a place where the blood-sucking pest is parasitic, the action of the blood-sucking pest can be stopped. Sexual pests can be controlled effectively.

  EXAMPLES Hereinafter, although an Example and a comparative example demonstrate this invention further, this invention is not restrict | limited to the following example.

(Examples 1-5, Comparative Examples 1-5)
Based on the formulation shown in Table 1 below, each component was added and mixed and stirred until it became uniform for about 10 minutes at room temperature to prepare specimen compositions of Examples 1 to 5 and Comparative Examples 1 to 5.

  One drop (0.4 to 3.0 μL) of each specimen composition is dropped onto a slide glass (26 mm × 76 mm) with a dropper, and the contact angle immediately after dropping is FACE contact angle meter CA-X type (trade name, Kyowa Interface) (Made by Science Co., Ltd.). All of the above were performed at room temperature of 25 ° C. The results are also shown in Table 1.

<Test Example 1: Measurement of time to stop action>
For each example, prepared a petri dish with the same size in a petri dish with a diameter of 9 cm, and dropped 1.6 mL of each of the sample compositions of Examples 1 to 5 and Comparative Examples 1 to 5 to the entire gauze. Spread out.
Subsequently, one female body lice was released on the gauze, and the time until the movement stopped and the movement stopped (time until the action was stopped) was measured. In addition, the measurement was performed up to 10 minutes after the test of body lice.
All tests are performed three times at room temperature of 25 ° C, the average is obtained, and the average of which the action is stopped within 60 seconds is evaluated as “◎” with high effect, and the action is stopped within 2 minutes after 60 seconds. What was done was evaluated with "(circle)" as having an effect, and what exceeded 2 minutes was evaluated with "x" as having no effect. The results are shown in Table 2.
In addition, it can be evaluated that if the time until the action is stopped is within 60 seconds, the action of the blood-sucking pest can be stopped more quickly, so that a high extermination effect can be obtained.

  From the results of Table 2, in Examples 1 to 5, the body lice stopped acting within 60 seconds in all tests, and on average the time until the action stopped was within 60 seconds. On the other hand, Comparative Examples 1 to 4 that contain a siloxane compound but have a contact angle of 31 degrees or greater, and Comparative Example 5 that does not contain a siloxane compound that has a contact angle of 31 degrees or less take time to stop action. Especially, in Comparative Examples 2, 3, and 5, there was a body lice that walked for 10 minutes or more. From these results, it was found that by applying a composition containing a siloxane compound and having a contact angle of 31 degrees or less, it is easy to penetrate adult lice and an excellent action stopping effect is obtained.

Claims (5)

  A composition comprising a siloxane compound as an active ingredient and having a contact angle with respect to a glass surface adjusted to 31 ° or less is applied to a blood-sucking pest or a place where a blood-sucking pest is parasitic. How to stop pest behavior.   The method according to claim 1, wherein the composition further contains a fatty acid ester.   The siloxane compound is at least one selected from the group consisting of dimethylpolysiloxane, decamethylcyclopentasiloxane, methylphenylpolysiloxane, amino-modified silicone and polyether-modified silicone. The method of stopping the action of the blood-sucking pest described in 1.   The method for stopping the action of blood-sucking pests according to any one of claims 1 to 3, wherein the siloxane compound contains dimethylpolysiloxane.   The said blood-sucking pest is at least 1 sort (s) selected from the group which consists of a chewing jaw pest, a relicent pest, and a half-pole pest, The any one of Claims 1-4 characterized by the above-mentioned. How to stop blood sucking pests.