JP2019007116A - Breast milk pad - Google Patents

Abstract

To provide a breast milk pad capable of fully suppressing a malodor caused by breast milk.SOLUTION: A breast milk pad (1) includes a fatty acid generation inhibitor, which inhibits production of fatty acids derived from lipids in the breast milk that causes unpleasant odors, thereby fully suppressing generation of a malodor caused by the breast milk in the breast milk pad. Because the fatty acid generation inhibitor targets short-chain fatty acids of carbon number 2-6 causing distasteful and strong odors among fatty acids derived from fats in the breast milk, and suppresses production of the short-chain fatty acids, it can suppress the generation of the malodor more effectively.SELECTED DRAWING: Figure 1

Description

  The present invention relates to a breast milk pad that is used while being worn inside an underwear such as a brassiere, and more particularly to a breast milk pad that can suppress the generation of malodor.

  Breast milk pads are known which prevent breastfeeding of breastfeeders such as mothers from leaking into underwear such as bras. In recent years, such a breast milk pad is required to suppress the generation of malodor caused by breast milk.

In general (especially in the food field, etc.), bad odor is caused by the generation of ammonia, organic acids, etc. produced by the degradation of amino acids by bacteria. It is known that the amount of odorous components such as organic acids can be reduced and the generation of malodor can be suppressed.
For example, Patent Document 1 discloses a water-permeable nonwoven fabric layer forming an upper surface, a water-absorbing first paper layer portion, a water-absorbing layer portion, a water-absorbing second paper layer portion, and a plastic forming a lower surface. And the first paper layer part is a dried product of one or more tea extraction residual waste liquids or a dried product of one or more tea cake leachates, or two or more of these. A sanitary sheet made of thin paper containing a mixture of dry matter is disclosed, and the use of this sanitary sheet in sanitary articles such as milk pads is also disclosed.
According to the sanitary sheet disclosed in Patent Document 1, Pseudomonas aeruginosa, Staphylococcus aureus, Legionella and the like are contained in a thin paper by using a dry product of tea extraction residual waste, a dry product of tea leaves leachate, or a mixture thereof. It is said that it can inhibit the growth of bacteria such as streptococci.

Japanese Patent Laid-Open No. 2000-129592

However, even if the technique for inhibiting the growth of bacteria disclosed in Patent Document 1 is applied to a breast milk pad, the unpleasant odor caused by the breast milk cannot be sufficiently suppressed, and the bad odor generated in the breast milk pad can be prevented. Currently, no solution has been reached.
Further, as means for suppressing bad odors, means using deodorant components such as deodorants are generally known, but most of such means do not suppress the generation of odor components that cause bad odors. Since the malodor is suppressed by adsorbing the generated odor component with the deodorant component, the effect cannot be fully exhibited unless the odor component contacts the deodorant component. However, in order to prevent such deodorant components from being taken orally by the infant through the breast of the wearer (lactating person), there are restrictions on the position of the deodorant component. Depending on the case, there is a possibility that the effect of the deodorant component cannot be sufficiently exhibited.

  Then, an object of this invention is to provide the breast milk pad which can fully suppress generation | occurrence | production of the malodor resulting from breast milk.

  The present inventors conducted extensive research and analysis on the cause of malodor caused by breast milk, and the malodor produced in the breast milk pad was found in the mother's milk rather than ammonia, organic acids, etc. produced by bacterial decomposition. Fatty acids (for example, butyric acid, caproic acid, caprylic acid, capric acid, lauric acid, etc.) produced by hydrolysis of the contained lipids by a lipase, also contained in breast milk, are the main causes And the generation of malodor in the breast milk pad can be sufficiently suppressed by suppressing the production of the fatty acid itself, and the present invention has been completed.

  One aspect (Aspect 1) of the present invention is a breast milk pad containing a fatty acid generation inhibitor that suppresses the generation of lipid-derived fatty acids in breast milk.

  Since the breast milk pad of this embodiment contains a fatty acid generation inhibitor that suppresses the generation of lipid-derived fatty acids in the breast milk, it suppresses the generation of fatty acids that cause unpleasant odors. The generation of bad odor can be sufficiently suppressed.

  Moreover, in another aspect (aspect 2) of this invention, in the breast milk pad of the said aspect 1, the said fatty acid is a C2-C6 short chain fatty acid.

  The breast milk pad of this aspect targets the short chain fatty acids having 2 to 6 carbon atoms that cause unpleasant and intense odor among the fatty acids derived from lipids in breast milk, and suppresses the occurrence of the above-mentioned malodorous odor. Generation | occurrence | production can be suppressed more efficiently.

  In still another aspect (Aspect 3) of the present invention, in the breast milk pad of Aspect 1 or 2, the fatty acid is selected from the group consisting of acetic acid, propionic acid, isobutyric acid, butyric acid, isovaleric acid, valeric acid, and caproic acid. It is at least one fatty acid selected.

  The breast milk pad of this aspect is limited to at least one fatty acid selected from the group consisting of acetic acid, propionic acid, isobutyric acid, butyric acid, isovaleric acid, valeric acid, and caproic acid, the fatty acid to be suppressed in generation. Therefore, by suppressing the generation of these fatty acids that cause particularly unpleasant and intense odor, the generation of malodor can be suppressed more accurately and effectively.

  In yet another aspect (Aspect 4) of the present invention, in the breast milk pad of any one of Aspects 1 to 3, the fatty acid generation inhibitor is an activity inhibitor against lipase.

  In the breast milk pad of this embodiment, since the fatty acid generation inhibitor is an activity inhibitor for lipase, the lipid contained in breast milk is hardly hydrolyzed by inhibiting the activity of lipase contained in breast milk, and fatty acid generation Can be accurately suppressed.

  In still another aspect (Aspect 5) of the present invention, in the breast milk pad of Aspect 4, the lipase is a lipoprotein lipase.

  In the breast milk pad of this embodiment, since the fatty acid generation inhibitor is an activity inhibitor against lipoprotein lipase, the lipase contained in breast milk (that is, Liporotein Lipase and bile acid-activated lipase (Bile Salt-Stimulated) Lipase)), particularly by inhibiting the activity of lipoprotein lipase, which is thought to contribute to the hydrolysis of lipids in breast milk, the lipids in breast milk are more difficult to hydrolyze, and the production of fatty acids is more accurate and It can be effectively suppressed.

  In still another aspect (Aspect 6) of the present invention, in the breast milk pad of Aspect 4 or 5, the activity inhibitor has a galloyl group in the molecular structure.

  In the breast milk pad of this embodiment, since the activity inhibitor for lipase has a galloyl group in its molecular structure, the galloyl group of the activity inhibitor binds to the active group of lipase that contributes to the hydrolysis of lipids in breast milk. By forming a state of antagonistic inhibition, lipids in breast milk are more reliably hardly hydrolyzed, and the production of fatty acids can be suppressed more reliably and effectively.

  In still another aspect (Aspect 7) of the present invention, in the breast milk pad of any one of Aspects 4 to 6, the activity inhibitor is a polyphenol having a galloyl group.

  In the breast milk pad of this embodiment, since the activity inhibitor for lipase is polyphenols having a galloyl group, it is easier to form the above-described competitive inhibition state, and the production of fatty acids can be more easily and accurately suppressed.

  In yet another aspect (Aspect 8) of the present invention, in the breast milk pad of Aspect 7, the polyphenols are polyphenols derived from plant bark, leguminous plants, tea or straw.

  The breast milk pad of this embodiment is a polyphenol derived from plant bark, leguminous plant rosemary, tea or strawberry, whose activity inhibitor against lipase has a galloyl group, and thus more accurately suppresses the generation of fatty acids as described above. In addition, since the activity inhibitor contained in the breast milk pad is derived from natural ingredients, the effect of the activity inhibitor on the human body (that is, the wearer's skin surface and the skin surface can be taken orally) It is possible to make it difficult for the wearer to feel uneasy, such as an influence on the infant (in other words, it is possible to give the wearer a sense of security).

  In yet another aspect (Aspect 9) of the present invention, the breast milk pad of Aspect 7 or 8 further includes a discoloration inhibitor that suppresses discoloration of the fatty acid generation inhibitor.

  Since the breast milk pad of this aspect further includes a discoloration inhibitor that suppresses discoloration of the fatty acid generation inhibitor, the generation of fatty acids can be sufficiently suppressed by the fatty acid generation inhibitor composed of the specific polyphenols described above. By including this discoloration inhibitor, it is possible to make it difficult to cause anxiety and discomfort to the wearer when the polyphenols of the fatty acid generation inhibitor are oxidized and discolored.

  In still another aspect (Aspect 10) of the present invention, in the breast milk pad of Aspect 9, the discoloration inhibitor is an antioxidant.

  In the breast milk pad of this embodiment, since the discoloration inhibitor that suppresses discoloration of the fatty acid generation inhibitor is an antioxidant, the oxidation of the polyphenols of the fatty acid generation inhibitor itself is suppressed, and the discoloration of the fatty acid generation inhibitor is further reduced. It can certainly be made difficult to occur.

  In still another aspect (Aspect 11) of the present invention, in the breast milk pad of any one of Aspects 9 to 10, the discoloration inhibitor includes water that is a solvent for the fatty acid generation inhibitor.

  Since the discoloration inhibitor that suppresses discoloration of the fatty acid generation inhibitor includes water that is a solvent of the fatty acid generation inhibitor, the breast milk pad of this aspect can accurately control the occurrence of discoloration of the above-described fatty acid generation inhibitor. In addition to being able to make discoloration inconspicuous (that is, making discoloration inconspicuous), it is also possible to make it difficult for the wearer to feel anxiety such as the effect on the human body by the discoloration inhibitor (ie, water).

  In yet another aspect (Aspect 12) of the present invention, in the breast milk pad of any one of Aspects 1 to 11, the breast pad is an inner sheet positioned on the skin surface side of the wearer and non-skin of the inner sheet. And the fatty acid generation inhibitor is disposed between the inner sheet and the absorber.

  Since the fatty acid generation inhibitor is arranged between the inner sheet and the absorbent body, the breast milk pad of this aspect can be brought into contact with the breast milk before being absorbed by the absorbent body. An inhibitor can be made to act more reliably on breast milk. In addition, when the fatty acid generation inhibitor is arranged on the non-skin surface side of the inner surface sheet, the fatty acid generation inhibitor is difficult to adhere to the skin surface of the wearer, and furthermore, the skin surface of the wearer (lactating person) Therefore, it is difficult for an infant to take orally through the body, so that it is difficult to give the wearer anxiety such as an influence on the human body by the fatty acid generation inhibitor.

  In still another aspect (Aspect 13) of the present invention, in the breast milk pad according to any one of Aspects 1 to 12, the fatty acid generation inhibitor is the most dense sheet among the plurality of sheets constituting the breast milk pad. Is arranged.

  The breast milk pad of this aspect is arranged on the highest density sheet among the plurality of sheets constituting the breast milk pad, so that the fatty acid generation inhibitor is caused by the movement of the wearer, the flow of breast milk, etc. It is difficult to move, and the action of the fatty acid generation inhibitor can be more reliably exhibited. Further, when the fatty acid generation inhibitor is likely to be discolored by oxidation or the like, the fatty acid generation inhibitor is discolored by such a high-density sheet. It can be made difficult to see.

  Yet another embodiment (embodiment 14) of the present invention is a fatty acid generation inhibitor for a breast milk pad that suppresses the generation of lipid-derived fatty acids in breast milk.

  The fatty acid generation inhibitor for breast milk pads of this embodiment suppresses the generation of fatty acid-derived fatty acids in breast milk, which causes unpleasant odors. Can be suppressed.

  ADVANTAGE OF THE INVENTION According to this invention, the mother's milk pad which can fully suppress generation | occurrence | production of the malodor resulting from mother's milk can be provided.

FIG. 1 is a perspective view of a breast milk pad 1 according to an embodiment of the present invention as viewed from the exterior sheet 5 side (non-skin surface side). FIG. 2 is a plan view of the breast milk pad 1 as viewed from the inner sheet 2 side (skin surface side) in the thickness direction _DT in a developed state. 3, the breast-milk pad 1 of Fig. 2 is a cross-sectional view along the longitudinal center axis C ₂ extending in the transverse direction D _C.

  Hereinafter, preferred embodiments of the breast milk pad of the present invention will be described in detail with reference to the drawings. In this specification, unless otherwise specified, “the object (for example, breast milk pad) placed on the horizontal surface in the unfolded state is viewed from the upper side in the vertical direction in the thickness direction of the object. Is simply referred to as “plan view”.

Various directions and the like used in this specification are as follows unless otherwise specified.
In this specification, the “longitudinal direction D _L ” of the breast milk pad refers to the “direction in the vertical direction when the breast pad is mounted in the plan view”, and the “lateral direction D _C ” is “in the plan view”. In the breast pad, it refers to the direction that is the left-right direction (horizontal direction) when the breast pad is mounted, and the “thickness direction D _T ” means “perpendicular to the breast pad placed on a horizontal surface in the unfolded state”. The vertical direction D _L , the horizontal direction D _C, and the thickness direction D _T are perpendicular to each other.
Further, in this specification, in the thickness direction _DT of the breast milk pad, “relatively proximal to the skin surface of the wearer when the breast milk pad is worn” is referred to as “skin side”, When the pad is worn, “relative to the skin surface of the wearer” is referred to as “non-skin surface”. Here, “at the time of wearing” refers to a period during which the wearer maintains the state from when the breast pad is worn (ie, when the wearable state is formed) (ie, while wearing). means.

FIG. 1 is a perspective view of a breast milk pad 1 according to an embodiment of the present invention as viewed from the exterior sheet 5 side (non-skin surface side), and FIG. 2 is an inner surface sheet in a state where the breast milk pad 1 is unfolded. It is the top view seen in thickness direction _DT from the 2nd side (skin surface side). Further, FIG. 3, the breast-milk pad 1 of Fig. 2 is a cross-sectional view along the longitudinal center axis C ₂ extending in the transverse direction D _C.
As shown in FIGS. 1 to 3, the breast milk pad 1 according to one embodiment of the present invention has a vertical direction D _L , a horizontal direction D _C and a thickness direction D _T perpendicular to each other, and in plan view, and it has an outer shape such that each of the end portions of lateral D _C is cut by a straight line extending in the longitudinal direction D _L of substantially circular shape. In the present invention, the external shape of the breast pad is not limited to that of such an embodiment, and any external shape (for example, circular or circular) can be used as long as it can cover the breast of the wearer. An ellipse, a square with rounded corners, etc.) can be employed.

Further, as shown in FIG. 3, the breast milk pad 1 in the above embodiment includes a liquid-permeable inner surface sheet 2 positioned on the skin surface side S ₁ of the wearer and a non-skin surface side in the thickness direction _DT . The liquid impervious outer sheet 3 positioned at S ₂ and the absorbent member 4 positioned therebetween are provided as a basic configuration, and further, the surface of the outer sheet 3 on the non-skin surface side S ₂ is hot. lateral D _C ends of and optional adhesive layer both end portions in the transverse direction D _C of the joined and the outer sheet 3 via the (not shown) so as to cover the non-skin side S _2, such as melt adhesives the outer sheet 5 parts is folded back to the skin surface S _1, 1 pair of elastic members EL extending sandwiched between and longitudinally D _L to folded portions of the outer sheet 5 (Incidentally, in this embodiment the elastic members EL, as shown in FIG. 3, one in the horizontal direction D _C Each end folded portion and the other end bent portion of the portion of the portion of the, in pairs and (total of four) are arranged.), Non-skin side S ₂ of the surface of the outer sheet 5 It includes a fastening portion 6 consisting of striped four adhesives such as extending, to disposed and longitudinally D _L on. In addition, these structural members except the fastening part 6 form a laminated structure in which the members are joined together by an arbitrary adhesive such as a hot-melt adhesive.

Such milk pad 1, the wearer's undergarment by the fastener part 6 arranged on the non-skin side S ₂ of the surface of the outer sheet 5 (for example, brassieres and the like) after being detachably fixed to the inner surface of, The inner surface sheet 2 is used in contact with the surface of the skin surface side S ₁ so as to cover at least part of the breast of the wearer.

And in the breast milk pad 1 of this embodiment, as shown in FIG. 3, the absorption member 4 is the absorption formed with the absorptive material (for example, a pulp, a super absorbent polymer, etc.) which can absorb and hold | maintain breast milk. the body 41, and the covering sheet 42 of the skin surface S placed skin side S ₁ so as to cover the surface of _one of the absorber 41, and covers the non-skin side S ₂ of the surface of the absorbent body 41 absorbs the body 41 and the cover sheet 42 covering sheet 43 of the non-skin side S ₂ arranged to surround the non-skin side S _2, is constituted by, further, the cover sheet 42 of the skin surface S ₁ Has a fatty acid generation inhibitor that suppresses the generation of fatty acids derived from lipids in breast milk. In the present embodiment, the fatty acid generator inhibitor, after an aqueous solution dissolved in water as a solvent, is arranged by applying the aqueous solution to the surface of the cover sheet 42 of the skin surface S ₁ Yes.

Thus, since the breast milk pad 1 of this embodiment contains the fatty acid generation inhibitor which suppresses generation | occurrence | production of the fatty acid derived from the lipid in breast milk, it suppresses generation | occurrence | production itself of the fatty acid which causes an unpleasant odor. As a result, generation of malodor derived from breast milk can be sufficiently suppressed.
Further, in the present embodiment, such a fatty acid generator inhibitor, since it is arranged on the covering sheet 42 of the skin surface S ₁ which is located between the inner sheet 2 and the absorbent body 41, a fatty acid generator inhibitor absorber It is easy to come into contact with breast milk before being absorbed by 41, and the fatty acid generation inhibitor can act on breast milk more reliably. Moreover, since the fatty acid generation inhibitor is located on the non-skin surface side S ₂ relative to the inner surface sheet 2, the fatty acid generation inhibitor is difficult to adhere to the skin surface of the wearer. Therefore, it is difficult for an infant to take orally through the skin surface of the person), and it is possible to make it difficult to give the wearer anxiety such as an effect on the human body due to the fatty acid generation inhibitor.

  Hereinafter, the main components constituting the breast milk pad of the present invention will be described in more detail using the breast milk pad 1 according to the above-described embodiment.

[Fatty acid generation inhibitor]
In the above embodiment, breast pads 1, the covering sheet 42 of the skin surface S ₁ which is positioned on the skin surface side S ₁ of the absorbent body 41, suppressing fatty generating suppress the generation of fatty acids derived from lipid in breast milk Agent is placed. Such a fatty acid generation inhibitor is used when the milk discharged from the wearer passes through the inner surface sheet 2 of the mother's milk pad 1 and reaches the covering sheet 42 on the skin surface side S ₁ described above. It is an activity inhibitor that acts to inhibit the activity of lipase (mainly lipoprotein lipase), which is a degrading enzyme. More specifically, the activity inhibitor used in the present embodiment binds to an active group that contributes to hydrolysis of lipids in breast milk in lipase to form a competitive inhibition state, whereby lipids in breast milk Is a kind of so-called enzyme inhibitor that makes it difficult to be hydrolyzed.

  In the present invention, the fatty acid generation inhibitor is not limited to the above-described activity inhibitor as long as it can suppress the generation of fatty acids derived from lipids contained in breast milk. Those that form reaction conditions and reaction environments that make it difficult to cause lipid hydrolysis reaction by itself, that is, hydrolysis reaction inhibitors (eg, dehydrating agents) and reaction environment regulators (eg, pH adjusters, exothermics) An agent etc.) can also be used.

  In the above-mentioned embodiment, since the activity inhibitor with respect to the lipase contained in breast milk is used as a fatty-acid generation inhibitor, the activity of the lipase which hydrolyzes the lipid contained in breast milk is inhibited, and by this hydrolysis Production of fatty acids such as butyric acid, caproic acid, caprylic acid, capric acid and lauric acid can be suppressed, and as a result, generation of malodor derived from breast milk in the breast milk pad 1 can be sufficiently suppressed.

  Here, the main lipids contained in breast milk are oleic acid (monovalent unsaturated fatty acid having 18 carbon atoms), palmitic acid (saturated fatty acid having 16 carbon atoms) and linoleic acid (bivalent unsaturated carbon having 18 carbon atoms). Saturated fatty acid) is a triglyceride bound, and when this triglyceride is hydrolyzed by the action of lipase, oleic acid and linoleic acid are selectively liberated, and this linoleic acid is further decomposed by enzymatic degradation, oxidative degradation, etc. Thus, it is presumed that various fatty acids (for example, fatty acids such as butyric acid, caproic acid, caprylic acid, capric acid, and lauric acid) that cause malodor are generated.

  Among various fatty acids that cause such malodors, short-chain fatty acids having 2 to 6 carbon atoms, particularly acetic acid, propionic acid, isobutyric acid, butyric acid, isovaleric acid, valeric acid, and caproic acid are strongly uncomfortable. In addition, in the present invention, the fatty acid generation inhibitor is a short one having 2 to 6 carbon atoms, because the smell is intense (that is, the odor can be perceived even in a small amount). Those that suppress the production of chain fatty acids are preferred, and those that inhibit the production of at least one fatty acid selected from the group consisting of acetic acid, propionic acid, isobutyric acid, butyric acid, isovaleric acid, valeric acid, and caproic acid are particularly preferred. . By targeting the short-chain fatty acids having 2 to 6 carbon atoms that cause such unpleasant and intense odors, the generation of malodor in the breast milk pad can be more efficiently suppressed by suppressing the generation thereof. Furthermore, the target fatty acid to be suppressed is at least one selected from the group consisting of acetic acid, propionic acid, isobutyric acid, butyric acid, isovaleric acid, valeric acid, caproic acid, which cause unpleasant and intense odor. By limiting the generation of these fatty acids to the fatty acids, the generation of malodor can be suppressed more accurately and effectively.

  The fatty acid generation inhibitor in the present invention is not particularly limited as long as it can suppress the generation of fatty acids derived from lipids contained in breast milk. For example, in addition to the activity inhibitor against lipase as described in the above embodiment. , Those that form reaction conditions and reaction environments that make lipid hydrolysis reaction with lipase less likely to occur, ie, hydrolysis reaction inhibitors (eg, dehydrating agents) and reaction environment regulators (eg, pH adjusters) , Exothermic agents, etc.) can also be used. Hydrolysis inhibitors and reaction environment regulators do not bind to the active group of lipase contained in breast milk (that is, they do not act on the lipase itself), but the reaction of lipid hydrolysis reaction by lipase itself. It suppresses the production of fatty acids by making it less likely to occur. For example, a dehydrating agent or desiccant that removes water contained in breast milk; weakly alkaline (preferably a hydrolysis reaction by lipase is difficult for the pH of breast milk) Is a pH adjuster that adjusts to pH 9.5 or higher; a heat generating agent that heats the temperature of breast milk to a temperature (preferably 50 ° C. or higher) at which hydrolysis reaction by lipase does not proceed easily.

  Among these various fatty acid generation inhibitors, from the viewpoint of the effectiveness of the fatty acid generation suppression effect in the breast milk pad and the safety against the influence on the human body such as the wearer and the infant, the activity inhibitor against the above lipase should be used. Is preferred. Compared to other fatty acid generation inhibitors, such activity inhibitors inhibit the activity of lipase contained in breast milk, regardless of the individual differences in breast milk components, the wearing state of the breast milk pad, or the wearing environment. Since it is easy, the lipid contained in breast milk can be more reliably prevented from being hydrolyzed, and the production of fatty acids can be more accurately suppressed.

  In the present invention, the form in which the activity inhibitor inhibits the activity of lipase is not particularly limited, and forms a competitive inhibition state by binding to an active group that contributes to hydrolysis in lipase as in the above embodiment. In addition to inhibiting the initiation of the hydrolysis reaction, it forms a state (non-antagonistic inhibition) that binds to a site different from the above-mentioned active group in lipase and makes it difficult to act on the lipid. Thus, it may be one that inhibits the progress of the hydrolysis reaction or a combination of these forms.

  Furthermore, in the present invention, the fatty acid generation inhibitor is preferably an activity inhibitor against lipoprotein lipase. If the fatty acid generation inhibitor is an activity inhibitor for lipoprotein lipase, among the lipases contained in breast milk (ie, lipoprotein lipase and bile acid activated lipase), it mainly contributes to the hydrolysis of lipids in breast milk. In order to inhibit the activity of the considered lipoprotein lipase, lipids in breast milk can be made more difficult to be hydrolyzed, and the production of fatty acids can be suppressed more accurately and effectively.

  In the present invention, the lipase activity inhibitor that can be used as a fatty acid generation inhibitor is not particularly limited as long as the effects of the present invention can be achieved, and examples thereof include tea catechins extracted from tea leaves such as green tea, black tea, and oolong tea. Catechins; tannins such as salmon tannins extracted from astringency; extracts of herbal medicines such as peonies, aurens, apricots, buttonpis, genus shochu, kudjin, dokatsu, ryokyo, areca, baiyou, ketsumeishi; Extracts of natural food materials such as maiko, hijiki, apple, ginseng, ginger, etc .; Or seeds, jasmine flowers or leaves, wild berries, soybean germs, legumes For example, in addition to naturally-derived components (particularly polyphenols such as catechins and tannins) such as extracts of plants such as leaves such as moxenna, pharmaceutical components such as cetiristat, orlistat, and evelactone B can also be used. .

  Among these activity inhibitors, those having a galloyl group in the molecular structure are preferable from the viewpoint of the activity inhibitory effect, and polyphenols having a galloyl group are more preferable. Plant bark, leguminous plant rosemary, tea Or the polyphenol which has a galloyl group derived from a cocoon is especially preferable.

If the activity inhibitor has a galloyl group in its molecular structure, the galloyl group binds to the active group of lipase that contributes to the hydrolysis of the lipid and forms a competitive inhibition state. Is more difficult to be hydrolyzed and the production of fatty acids can be more reliably and effectively suppressed. Furthermore, when the activity inhibitor is a polyphenol having a galloyl group, it becomes easier to form the above-described antagonistic inhibition state, so that the production of fatty acids can be more easily and accurately suppressed. In particular, when the polyphenols having a galloyl group are polyphenols derived from plant bark, leguminous plants, tea or straw, the production of fatty acids can be more accurately suppressed as described above, and a breast milk pad When the activity inhibitor contained in is derived from a natural component, it is possible to make it difficult to give the wearer anxiety such as the effect of the activity inhibitor on the human body. Such polyphenols having a galloyl group include epigallocatechin gallate (EGCg), epicatechin gallate (ECg), catechin gallate (Cg), gallate catechins such as gallocatechin gallate (GCg), and tannins. Can be mentioned.
Of the above polyphenols having a galloyl group, catechin gallate and gallocatechin gallate are scarcely present in natural plants including tea leaves, and thus epigallocatechin gallate, epicatechin gallate or a mixture thereof is heat-treated (for example, , 80 ° C. or higher) and thermal isomerization (epimerization).

[Discoloration inhibitor]
And when a breast milk pad contains the above-mentioned polyphenols as a fatty-acid generation inhibitor, it is preferable that the breast-milk pad further contains the discoloration inhibitor which suppresses discoloration of a fatty-acid generation inhibitor. When the breast milk pad contains such a discoloration inhibitor, the generation of fatty acids can be sufficiently suppressed by the fatty acid generation inhibitor composed of the above-mentioned polyphenols, and the polyphenol of the fatty acid generation inhibitor can be suppressed by the discoloration inhibitor. It is possible to suppress the discoloration due to oxidation. Thereby, it can be made hard to produce that a fatty-acid-generation inhibitor discolors and gives an anxiety and discomfort to a wearer.

  In the present invention, the discoloration inhibitor is not particularly limited as long as it can suppress discoloration of the fatty acid generation inhibitor composed of the above-mentioned polyphenols. For example, vitamin C, (ascorbic acid), vitamin E (tocophenol) In addition to antioxidants such as dibutylhydroxytoluene (BHT), butylhydroxyanisole (BHA) and isoascorbic acid, water as a solvent for fatty acid generation inhibitors can be used.

  Since the above-mentioned antioxidant suppresses the oxidation itself of the polyphenols of the fatty acid generation inhibitor, it is possible to more reliably prevent discoloration of the fatty acid generation inhibitor. Further, water as a discoloration inhibitor can be easily added by lowering the concentration of the aqueous solution of the fatty acid generation inhibitor, thereby accurately controlling the occurrence of discoloration of the above-described fatty acid generation inhibitor. In addition to being able to make discoloration inconspicuous (that is, making discoloration inconspicuous), it is also possible to make it difficult for the wearer to feel anxiety such as the effect on the human body by the discoloration inhibitor (ie, water).

Moreover, in this invention, you may provide the discoloration concealment means which conceals discoloration of the fatty-acid generation inhibitor which consists of the above-mentioned polyphenol instead of the above-mentioned discoloration inhibitor or with a discoloration inhibitor.
Such discoloration concealing means is not particularly limited as long as it can conceal the discoloration of the above-described fatty acid generation inhibitor. For example, the color after discoloration of the above-mentioned fatty acid generation inhibitor is the skin surface side of the breast milk pad. And / or a colored sheet colored with a colorant (for example, pigment or dye) of a color that is not visible from the surface on the non-skin surface side (a concealed color) or a color (complementary color) that makes the color after the above-mentioned discoloration inconspicuous; Concealing sheets such as sheets having a high density such that the color after the discoloration of the fatty acid generation inhibitor is not visible from the skin side and / or the non-skin side surface of the breast milk pad, or are difficult to see, are mentioned. The concealing sheet may be separately disposed on the skin surface side and / or the non-skin surface side of the sheet containing the fatty acid generation inhibitor, or the sheet itself containing the fatty acid generation inhibitor. Or inside With or outer sheet may be a sheet-like member constituting the breast-milk pad, such as the exterior sheet.

[Inner sheet]
In the above embodiment, the inner sheet 2 for use in breast milk pad 1, as shown in FIGS. 2 and 3, in plan view, from one side of the edge in the longitudinal direction D _L of the breast-milk pad 1 on the other side together extending across the edge, extending from the edge of one side over the edge of the other side in the transverse direction D _C, a similar outer shape and dimensions and overall external shape and dimensions of the breast pads 1 Yes and has, in the thickness direction D _T of the breast pads 1 (specifically, the skin surface of the breast of the wearer) the wearer's skin surface is disposed in contact may position the skin surface S ₁ on, capable of a to quickly transition to the absorbent member 4 which is located the milk discharged from the wearer to the non-skin side S _2, formed by a liquid-permeable sheet-like member.
In the present invention, the outer shape of the inner surface sheet is not limited to such a specific form, and any outer shape (for example, as long as it can cover the breast of the wearer) A circle, an ellipse, a square with rounded corners, etc.) can be employed.

  The liquid-permeable sheet-like member that can be used as the inner sheet is not particularly limited as long as it has a predetermined liquid permeability that can permeate breast milk. For example, non-woven fabrics and woven fabrics such as air-through nonwoven fabric and spunbond nonwoven fabric. A sheet-like fiber structure (that is, a fiber sheet) such as a cloth or a knitted fabric; a perforated resin film having a plurality of perforations can be suitably used. Such a sheet-like member may be subjected to a hydrophilization treatment with a surfactant, and may contain any additive such as a deodorant or an antibacterial agent. In addition, these additives may be used independently or may use 2 or more types together.

When the above-mentioned fiber sheet is used as the inner sheet, the constituent fibers thereof are not particularly limited. For example, cellulose fibers such as pulverized pulp, cellulose fibers such as cotton, regenerated cellulose fibers such as rayon, and semisynthetic cellulose fibers such as acetate. Fibers: Polyolefin resins such as polyethylene and polypropylene; Thermoplastic resins such as polyester resins such as polyethylene terephthalate, or resin fibers made of a thermoplastic resin composition in which two or more of these thermoplastic resins are arbitrarily combined These fibers may be used alone, or two or more kinds of fibers may be used in combination.
Moreover, when using the above-mentioned apertured resin film as the inner sheet, the constituent resin is not particularly limited. For example, polyolefin resins such as polyethylene and polypropylene, polyester resins such as polyethylene terephthalate and polylactic acid, 6-nylon and the like Or a thermoplastic resin composition in which two or more of these thermoplastic resins are arbitrarily combined.

  The outer dimensions (thickness, etc.) and basis weight of the liquid-permeable sheet-like member that can be used as the inner sheet are not particularly limited as long as the sheet-like member can function as the inner sheet of the breast milk pad, Arbitrary external dimensions, basic weights, etc. according to desired liquid permeability, intensity, etc. are employable.

[External sheet]
In the above embodiment, the outer sheet 3 used in the breast milk pad 1, in plan view, the longitudinal direction D _L and extends in the transverse direction D _C and the non-skin side surface of the absorbent member 4 of the breast pads 1 In the thickness direction of the breast milk pad 1, for example, 60% or more of the surface area of the non-skin surface side S ₂ of the absorbent member 4. In D _T , breast milk that is disposed on the non-skin surface side S ₂ of the absorbent member 4 and absorbed and held in the breast milk pad 1 (particularly the absorbent member 4) does not leak out of the breast milk pad 1. It is formed by a liquid-impermeable sheet-like member. In the present embodiment, the outer sheet 3 is bonded through a part and the hot-melt adhesive optional adhesive layer, such as a non-skin side S ₂ of the surface of the absorbent member 4 (not shown) ing.
In the present invention, the outer shape of the outer sheet is not particularly limited as long as the outer sheet can function as the outer sheet, and any outer shape (for example, a circle, an ellipse, a square with rounded corners, or an inner sheet) Can be employed.

  The liquid-impermeable sheet-like member that can be used as the outer sheet is not particularly limited as long as it has a predetermined liquid-impermeable property that can prevent the transmission of breast milk (more preferably, it has air permeability), For example, a non-woven fabric such as an SMS nonwoven fabric, a spunbond nonwoven fabric, a point bond nonwoven fabric, or a porous or nonporous resin sheet made of a synthetic resin material, which is made of a waterproof synthetic resin or a hydrophobic synthetic resin fiber, is preferably used. be able to. Such a sheet-like member may contain an arbitrary additive such as a deodorant or an antibacterial agent, and these additives may be used alone or in combination of two or more.

  Further, when the above-described nonwoven fabric or resin sheet is used as the outer sheet, the constituent material (in the case of a nonwoven fabric, the material forming the constituent fibers of the nonwoven fabric) is not particularly limited as long as it does not impair liquid impermeability. For example, a polyolefin resin such as polyethylene or polypropylene; a thermoplastic resin such as a polyester resin such as polyethylene terephthalate; or a thermoplastic resin composition in which two or more of these thermoplastic resins are arbitrarily combined is preferably used. be able to.

  The external dimensions and basis weight of the liquid-impermeable sheet-like member that can be used as the outer sheet are not particularly limited as long as the sheet-like member can function as the outer sheet of the breast milk pad. Arbitrary external dimensions, basis weights, etc. according to the impermeability etc. can be adopted.

  In addition, since it is not an essential constituent requirement in the breast milk pad of the present invention to have such an outer sheet, for example, when an exterior sheet described later can also function as an outer sheet, Such an outer sheet may not be provided.

[Absorber]
In the above embodiment, the absorbent member 4 used in the breast milk pad 1, as shown in FIG. 2, in plan view, a transverse central axis C ₁ extending in the central portion (the longitudinal direction D _L of the breast pads 1 horizontal located in a region including a portion) comprising an intersection of the longitudinal center axis C ₂ extending in a direction D _C, similar to the overall outer shape of the breast-milk pad 1 described above, both end portions of the lateral D _C of the substantially circular shape There which has a longitudinal direction D outline shape as is cut by a straight line extending _L, and has a smaller outside dimension slightly larger than the outer dimensions of the breast-milk pad 1.
Furthermore, the absorbent member 4 is disposed between the inner sheet 2 and the outer sheet 3 in the thickness direction _DT of the breast pad 1 and absorbs and holds the breast milk that has passed through the inner sheet 2. It has.
In the present invention, the outer shape of the absorbent member is not limited to that of the specific aspect as described above, and any outer shape (for example, a circle or an ellipse) can be used as long as it can exhibit a predetermined absorption performance. , Rectangles, squares with rounded corners, etc.) can be employed.

In the above-described embodiment, the absorbent member 4 includes an absorbent body 41 made of an absorbent material made of a mixture of hydrophilic fibers such as pulp and particulates of a super absorbent polymer (SAP), and the absorbent body 41. The covering sheet 42 on the skin surface side S ₁ disposed so as to cover the surface of the skin surface side S _{1, and} the surface of the non-skin surface side S ₂ of the absorbent body 41 and the absorbent body 41 and the covering sheet 42 on the non-skin a cover sheet 43 of the side S ₂ arranged so as to wrap from, non-skin face side S _2, is constituted by, further, the cover sheet 42 of the skin surface S ₁ described above, derived from lipids in the milk The fatty acid generation inhibitor which suppresses generation | occurrence | production of the fatty acid to perform is arrange | positioned.

  In the present invention, the arrangement position of the fatty acid generation inhibitor is not particularly limited as long as the effect of the present invention is not impaired, and the fatty acid generation inhibitor is, for example, an inner surface sheet in addition to the above-mentioned skin-side covering sheet. Non-skin-side surface or inside, intermediate-skin surface and / or non-skin-side surface or inside of an intermediate sheet arbitrarily disposed on the non-skin-side of the inner sheet, absorbent skin-side surface or It can be placed at any position such as inside (ie, mixed with an absorbent material such as pulp). However, when the fatty acid generation inhibitor is arranged between the inner sheet and the absorber as in the above-described embodiment, the fatty acid generation inhibitor is more reliably applied to the breast milk before being absorbed by the absorber. In addition to being able to act, the fatty acid generation inhibitor is located on the non-skin surface side of the inner surface sheet, so that the fatty acid generation inhibitor is less likely to adhere to the skin surface of the wearer. Since it is difficult for the baby to take it orally via the skin surface of the (lactator), there is also an advantage that it is possible to make it difficult to give the wearer an anxiety such as an influence on the human body by the fatty acid generation inhibitor.

  In another aspect, the fatty acid generation inhibitor is arranged on the highest density sheet among a plurality of sheets constituting the breast milk pad (for example, the above-mentioned inner surface sheet, intermediate sheet, skin surface covering sheet, etc.). May be. When the fatty acid generation inhibitor is placed on such a high-density sheet, the fatty acid generation inhibitor is less likely to move due to the movement of the wearer or the flow of breast milk. In addition, when the fatty acid generation inhibitor is easily discolored due to oxidation or the like, the high-density sheet can make the discoloration of the fatty acid generation inhibitor difficult to be visually recognized.

  Here, the absorptive material that can be used for the absorber is not limited to the above-described embodiment as long as it can absorb and retain breast milk, and any absorptive material known in the art can be used. . Examples of such absorbent materials include pulps such as fluff pulp, cellulosic fibers such as cotton, rayon, and acetate; particulates made of superabsorbent polymer such as sodium acrylate copolymer; and any combination thereof. A mixture etc. are mentioned.

Further, the covering sheet disposed on each of the skin surface side and the non-skin surface side of the absorbent body is not particularly limited as long as it does not inhibit the effect of the present invention, for example, it is formed using softwood bleached kraft pulp as the main raw material, basis weight may be used 10.0g ^{/ m 2} ~15.0g ^/ m 2 about tissue paper or air-through nonwoven fabric, any non-woven fabric, such as spunbond nonwoven fabric.

  The overall outer dimensions, basis weight, etc. of the absorbent member are not particularly limited as long as they do not impair the effects of the present invention, and any external dimensions, basis weight, etc. according to the desired absorption performance, strength, etc. should be adopted. Can do.

[Exterior sheet]
In the above embodiment, the outer sheet 5 used in the breast milk pad 1, in plan view, as well as extending from one side of the edge in the longitudinal direction D _L of the breast-milk pad 1 over the edge of the other side, transverse extending from the edge of one side over the edge of the other side of the D _C, it has the same outer shape and dimensions and overall external shape and dimensions of the breast-milk pad 1 (see Figure 1), In the thickness direction _DT of the breast milk pad 1, the outer surface sheet 3 is bonded to the surface of the non-skin surface side S ₂ of the outer surface sheet 3 via an arbitrary adhesive layer (not shown) such as a hot-melt adhesive. of both end portions in the transverse direction D _C in the wrap from the non-skin side S _2, both end portions of the lateral D _C are arranged in a state of being folded back to the skin surface S ₁ (see Figure 3). The exterior sheet 5 is located on the non-skin surface side S ₂ most in the breast milk pad 1, and the breast milk absorbed and held in the breast milk pad 1 (particularly the absorbent member 4) is the breast milk pad 1 in the same manner as the outer sheet 3. It is formed by a liquid-impermeable sheet-like member that defines the external shape of the breast milk pad 1 while preventing it from leaking to the outside.
In the present invention, the outer shape of the outer sheet is not particularly limited as long as it can function as the outer sheet, and any outer shape (for example, a circle, an ellipse, a square with rounded corners, etc.) is adopted. can do.

  The liquid-impermeable sheet-like member that can be used as the exterior sheet is not particularly limited as long as it has a predetermined liquid-impermeable property that can prevent the transmission of breast milk (more preferably, it has air permeability), For example, the same non-woven fabric or resin sheet as the above outer sheet can be used. The exterior sheet may be composed of one sheet-like member or may be composed of two or more sheet-like members.

  The outer dimensions, basis weight, etc. of the liquid-impermeable sheet-like member that can be used as the outer sheet are not particularly limited as long as the sheet-like member can function as an outer sheet of the breast milk pad. Arbitrary external dimensions, basis weights, etc. according to properties and strength can be adopted.

  Moreover, since it is not an essential constituent requirement in the breast milk pad of the present invention to have such an exterior sheet, for example, when the above-described outer sheet can also function as an exterior sheet, Such an exterior sheet may not be provided.

  The breast milk pad of the present invention is not limited to the above-described embodiment and the like, and can be appropriately combined, substituted, changed and the like within the scope not departing from the object and spirit of the present invention. In this specification, ordinal numbers such as “first” and “second” are used to distinguish items with the ordinal numbers, and mean the order, priority, importance, etc. of each item. Not what you want.

  Hereinafter, the present invention will be described more specifically by way of examples and comparative examples. However, the present invention is not limited to these examples.

Assuming a breast milk pad containing the fatty acid generation inhibitor of the present invention, the effects of various fatty acid generation inhibitors on the activity of lipase contained in actual breast milk were examined.
Example 1
A commercial product of polyphenols containing a large amount of epigallocatechin gallate having a galloyl group in the molecular structure as a fatty acid generation inhibitor in the actual breast milk provided by breastfeeding donors (made by ITO EN Co., Ltd. 30A ") was added at an addition amount (mass%) of 0.5%, and the enzyme activity amount (µmol / L) of lipase immediately after the addition and after a predetermined time while keeping the temperature at 37 ° C is described below <Enzyme activity The amount was measured based on the method of measuring amount>.
On the other hand, the amount of enzyme activity of lipase was measured at the same time for breast milk to which no fatty acid generation inhibitor was added (hereinafter referred to as “non-added breast milk”). The ratio (%) of the enzyme activity amount of Example 1 when the enzyme activity amount was 100% was calculated every time, and the obtained value was defined as the lipase enzyme activity decrease rate (%).

<Method for measuring enzyme activity>
(1) Preparation of various reagents Various reagents for the substrate solution, the reaction stop solution, and the calibration curve sample solution are prepared at the following blending ratios.
(A) Substrate solution 1 mol / L trishydroxymethylaminomethane (Tris) 3 mL, 50 mmol / L 2-methoxyethanol 60 μL diluted with distilled water, 103 mmol / L myristic acid diluted with dimethyl sulfoxide (DMSO) A substrate solution is prepared by mixing 120 μL of ρ-nitrophenyl and 8.82 mL of distilled water in a predetermined container.
(B) Reaction Stop Solution A reaction stop solution is prepared by mixing 15 mL of acetone and 6 mL of n-heptane in a predetermined container.
(C) Calibration curve sample solution ρ-nitrophenol is dissolved in DMSO to prepare a 1 mol / L solution (1M solution). This 1M solution was diluted 100-fold with 0.25 mol / L Tris to prepare a 10 mmol / L solution (10 mM solution), and further diluted with 0.25 mol / L Tris as appropriate. Prepare sample solution.
(2) Measurement of lipase enzyme activity (μmol / L)
(i) Inject 0.5 mL of the substrate solution into a 2 mL tube.
(ii) 10 μL of a measurement sample (breast milk and breast milk containing a fatty acid generation inhibitor) is injected into a 2 mL tube into which the substrate solution has been injected, and immediately incubated in a water bath heated to 30 ° C.
(iii) After 15 minutes, 0.7 mL of the reaction stop solution is added to the 2 mL tube.
(iv) Swivel 2 mL of the reaction stop solution added with a vortex mixer to suspend the content solution, and further centrifuge at a centrifugal force of 6100 × g for 2 minutes.
(v) Collect 5 mL of the lower aqueous layer from the content liquid after centrifugation in a separate 2 mL tube.
(vi) Transfer the collected sample solution and the sample solution for calibration curve to a 96-well plate by 200 μL each.
(vii) The absorbance at 405 nm indicating the presence of ρ-nitrophenol is measured with an absorbance plate reader.
The detected amount of ρ-nitrophenol measured here corresponds to the amount of ρ-nitrophenol produced by hydrolysis of ρ-nitrophenyl myristate with lipase.

Example 2
The amount of lipase enzyme activity after each time was measured in the same manner as in Example 1 except that the addition amount of the fatty acid generation inhibitor was changed to 1.0%. Further, the lipase enzyme activity in Example 2 was decreased. The rate value was determined.

Examples 3-5
As a fatty acid generation inhibitor, a commercially available polyphenol product (manufactured by Release Kagaku Kogyo Co., Ltd., trade name “PANCIL COS-17”) containing a large amount of tannin having a galloyl group in the molecular structure is used. Except for changing to 5%, 10% and 20%, the amount of lipase enzyme activity was measured for each hour in the same manner as in Example 1, and the lipase enzyme activity reduction rate of Examples 3 to 5 was further measured. The value was determined.

Comparative Example 1
Each time in the same manner as in Example 1 except that rutin, which is a polyphenol having no galloyl group in the molecular structure, was used as the fatty acid generation inhibitor and the addition amount (% by mass) was changed to 0.125%. The amount of enzyme activity of the lipase was measured for each time, and the value of the enzyme activity reduction rate of the lipase of Comparative Example 1 was further determined.

  The values of the enzyme activity reduction rate of the lipases obtained in this manner and in each of the comparative examples are shown in Table 1 below.

As shown in Table 1, Examples 1 to 5 using a polyphenol having a galloyl group (epigallocatechin or tannin) as a fatty acid generation inhibitor have a low lipase enzyme activity reduction rate, and have sufficient lipase activity. It turned out that it was able to suppress.
On the other hand, in Comparative Example 1 using polyphenol (rutin) having no galloyl group, the reduction rate of enzyme activity of lipase is higher than that of non-added breast milk. Since it was accelerated | stimulated, it turned out that the rutin used for the comparative example 1 does not function as a fatty-acid-generation inhibitor.
Moreover, from comparison between Examples 1 and 2 and Examples 3 to 5, it was found that salmon tannin has an extremely excellent lipase activity inhibitory effect.

DESCRIPTION OF SYMBOLS 1 Breast milk pad 2 Inner surface sheet 3 Outer surface sheet 4 Absorbing member 41 Absorbent body 42 Skin surface side coating sheet 43 Non skin surface side coating sheet 5 Exterior sheet 6 Fastening part

Claims (14)

  A breast milk pad comprising a fatty acid generation inhibitor that suppresses the generation of lipid-derived fatty acids in breast milk.   The breast milk pad according to claim 1, wherein the fatty acid is a short chain fatty acid having 2 to 6 carbon atoms.   The breast milk pad according to claim 1 or 2, wherein the fatty acid is at least one fatty acid selected from the group consisting of acetic acid, propionic acid, isobutyric acid, butyric acid, isovaleric acid, valeric acid, and caproic acid.   The breast milk pad according to any one of claims 1 to 3, wherein the fatty acid generation inhibitor is an activity inhibitor against lipase.   The breast milk pad according to claim 4, wherein the lipase is a lipoprotein lipase.   The breast milk pad according to claim 4 or 5, wherein the activity inhibitor has a galloyl group in the molecular structure.   The breast milk pad according to any one of claims 4 to 6, wherein the activity inhibitor is a polyphenol having a galloyl group.   The breast milk pad according to claim 7, wherein the polyphenols are polyphenols derived from plant bark, leguminous plants, tea or persimmon.   The breast milk pad of Claim 7 or 8 which further contains the discoloration inhibitor which suppresses discoloration of the said fatty-acid generation inhibitor.   The breast milk pad of Claim 9 whose said discoloration inhibitor is antioxidant.   The said discoloration inhibitor is a breast milk pad as described in any one of Claims 9-10 containing the water which is a solvent of the said fatty-acid generation inhibitor. The breast milk pad has an inner surface sheet located on the skin surface side of the wearer, and an absorbent body located on the non-skin surface side of the inner surface sheet,
The breast milk pad according to any one of claims 1 to 11, wherein the fatty acid generation inhibitor is disposed between the inner surface sheet and the absorber.   The said fatty acid generation | occurrence | production inhibitor is a breast milk pad as described in any one of Claims 1-12 arrange | positioned at the highest density sheet | seat among several sheets which comprise the said breast milk pad.   A fatty acid generation inhibitor for breast milk pads, which suppresses generation of lipid-derived fatty acids in breast milk.

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