JP2018058816A - Hair restorer composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide hair restorer compositions having good low-temperature stability, excellent hair loss inhibitory effect, excellent hair growth promotion effect, excellent less stickiness, excellent softness of the parietal hair, and excellent moisture retention effect of the scalp.SOLUTION: A hair restorer composition contains: (A) 0.1 mass% to 5 mass% of at least one hair restoration active ingredient selected from 6-benzyl aminopurine, glyceride pentadecanoic acid, and minoxidil; (B) 55 mass% to 85 mass% of ethanol; (C) 0.00001 mass% to 0.001 mass% of hyaluronate sodium with a viscosity average molecular weight of 800,000 to 2,700,000; and (D) 1 mass% to 5 mass% of polyethyleneglycol with an average molecular weight of 190 to 420, the mass ratio (D/C) of the content (mass%) of the component (C) and the content (mass%) of the component (D) being 2,000 to 400,000.SELECTED DRAWING: None

Description

  The present invention relates to a hair restorer composition.

  In recent years, since consumers' awareness of scalp care has increased, a moisturizing effect of the scalp is also required in preparations used for the scalp such as hair restorers. In addition, examples of the scalp site that uses the hair-restoring agent include the frontal region and the parietal region, and the parietal region is known to be a region that has a low water content and is easy to dry in the scalp. .

  Then, in order to make the scalp moisturizing effect favorable, the hair restorer containing a hyaluronic acid or its salt is proposed, for example (for example, refer patent documents 1-4). Moreover, in the hair restorer currently marketed, in order to dissolve the hair growth active ingredient, many ethanol are contained (for example, refer patent document 5). In this hair restorer with a high ethanol content, hyaluronic acid is aggregated by ethanol and oli (precipitate) is generated, so that it cannot contain hyaluronic acid enough to give the scalp moisturizing effect. In order to contain, it is necessary to reduce the ethanol content.

However, if the ethanol content is reduced to contain hyaluronic acid, the amount of active hair-growth ingredients can be reduced, the softness of the hair on the top of the head is impaired, the hair growth promoting effect on the top and the moisturizing of the scalp. There was a problem that it was difficult to achieve both effects. Furthermore, the hair-growth active ingredient is in a supersaturated state at a low temperature, and there is a problem that it precipitates with time in the hair-growth composition.
In addition, the lack of stickiness has not been fully studied.

  Therefore, it is desired to provide a hair-restoring agent composition having good low-temperature stability, excellent hair loss inhibiting effect, hair growth promoting effect, no stickiness, softness of hair on the top of the head, and moisturizing effect on the scalp.

JP 2010-163418 A JP, 2015-40173, A JP 2001-131031 A JP 2008-247752 A JP 2011-153122 A

  An object of the present invention is to solve the above-described problems and achieve the following objects. That is, the present invention provides a hair restorer composition having good low-temperature stability, excellent hair loss inhibiting effect, hair growth promoting effect, no stickiness, softness of hair on the top of the head, and moisturizing effect on the scalp. With the goal.

  In order to solve the above problems, the present inventor has conducted extensive studies, and as a result, contains (A) a hair-growth active ingredient, (B) ethanol, (C) sodium hyaluronate, and (D) polyethylene glycol, ) The content ratio (D / C) of the content (% by mass) of the component and the content (% by mass) of the (D) component is 2,000 to 400,000. Thus, it was found that a hair growth agent composition having excellent low-temperature stability, excellent hair loss suppressing effect, hair growth promoting effect, no stickiness, softness of hair on the top of the head, and moisturizing effect on the scalp can be obtained.

This invention is based on the said knowledge by this inventor, and as a means for solving the said subject, it is as follows. That is,
<1> (A) 0.1 mass% to 5 mass% of at least one hair restoring active ingredient selected from 6-benzylaminopurine, pentadecanoic acid glyceride, and minoxidil;
(B) 55% by mass to 85% by mass of ethanol;
(C) 0.00001% by mass to 0.001% by mass of sodium hyaluronate having a viscosity average molecular weight of 800,000 to 2,700,000,
(D) 1 to 5% by mass of polyethylene glycol having an average molecular weight of 190 to 420,
The mass ratio (D / C) of the content (mass%) of the component (C) and the content (mass%) of the component (D) is 2,000 to 400,000. The hair restorer composition.
<2> (E) Coleus The hair restorer composition according to <1>, further including a forskori extract.

  According to the present invention, it is possible to solve the above-described problems and achieve the above-mentioned object, have good low-temperature stability, hair loss suppressing effect, hair growth promoting effect, no stickiness, and soft hair on the top of the head. It is possible to provide a hair restorer composition that is excellent in feeling and moisturizing effect on the scalp.

(Hair restorer composition)
The hair restorer composition of the present invention comprises (A) a hair growth active ingredient, (B) ethanol, (C) sodium hyaluronate, and (D) polyethylene glycol, and (E) Coleus false as needed. Contains Kori extract and other ingredients.

<(A) Hair-growth active ingredient>
The hair-growth active ingredient of the component (A) is contained in order to improve the hair loss suppressing effect, the hair growth promoting effect, no stickiness, the softness of the hair on the top of the head, and the low-temperature stability.

The hair-growth active ingredient of the component (A) contains at least one selected from 6-benzylaminopurine, pentadecanoic acid glyceride, and minoxidil. In addition, in the hair restorer composition of this invention, you may contain the hair restorer active ingredient other than the said (A) component further as needed.
Among these, 6-benzylaminopurine, pentadecanoic acid glyceride, and minoxidil are preferable in terms of hair loss suppressing effect, hair growth promoting effect, no stickiness, softness of hair on the top of the head, and low temperature stability. Aminopurine is more preferred.

Here, the 6-benzylaminopurine is a white crystalline powder having a molecular weight of 225.26 represented by the following structural formula, and is also called 6-benzyladenine.

The 6-benzylaminopurine is a hair-restoring agent (see JP-A-5-320028 and JP-A-7-233037), skin cosmetics for the purpose of preventing skin aging and activating cells by external application to the scalp. (Refer to Yutaka Mishima et al., Skin No. 40, No. 4, P407-413, August 1998).
As said 6-benzylamino purine, what was synthesize | combined suitably may be used and a commercial item may be used.
There is no restriction | limiting in particular as said synthesis method, According to the objective, it can select suitably, For example, the method of synthesize | combining according to Unexamined-Japanese-Patent No. 2005-35903, the method of refine | purifying from a natural product, etc. are mentioned.

  There is no restriction | limiting in particular as an acquisition method of the said (A) component, According to the objective, it can select suitably, What was synthesize | combined may be used and a commercial item may be used. Examples of the commercially available products include 6-benzylaminopurine (manufactured by Sansho Pharmaceutical Co., Ltd.), pentadecanoic acid monoglyceride (manufactured by Lion Chemical Co., Ltd.), minoxidil (manufactured by Sigma Aldrich Japan Co., Ltd.), and the like.

  As the content of the hair-growth active ingredient of the component (A), from the viewpoint of hair loss suppressing effect, hair growth promoting effect, no stickiness, softness of hair on the top of the head, and low temperature stability, It is 0.1 mass%-5 mass% with respect to the whole quantity, and 0.5 mass%-3 mass% are preferable. When the content is less than 0.1% by mass, the hair loss suppressing effect and the hair growth promoting effect are insufficient, and when it exceeds 5% by mass, there is no stickiness, the softness of the hair on the top of the head, and the low temperature. Stability is reduced.

<(B) Ethanol>
The component (B) ethanol is contained in order to improve the non-stickiness, the softness of the hair on the top of the head, the moisturizing effect of the scalp, and the low temperature stability.

  Examples of the component (B) ethanol include absolute ethanol, 95% by volume ethanol (standard value 95% by volume to 95.5% by volume), and the like.

  The ethanol content of the component (B) is anhydrous with respect to the total amount of the hair restorer composition from the viewpoints of no stickiness, softness of hair on the top of the head, moisturizing effect of the scalp, and low temperature stability. It is 55 mass%-85 mass% in ethanol conversion, and 65 mass%-80 mass% is preferable. When the content is less than 55% by mass, there is no stickiness and the softness of the hair at the top of the head, and when it exceeds 85% by mass, the moisturizing effect of the scalp and low-temperature stability are degraded.

Here, content of the said (B) component is a total content of the absolute ethanol containing ethanol brought in from these components, when a plant extract etc. are mix | blended as another component.
When 95 volume% ethanol is used, the content (mass%) in terms of absolute ethanol can be obtained by the following formula 1 (Independent Administrative Institution Pharmaceuticals and Medical Devices Agency Document 038-1309.pdf) and formula 2. it can.
Ethanol mass% = volume% × 0.79422 (specific gravity of 100% by volume at 15 ° C.) / D (specific gravity at 15 ° C.) Formula 1
= (95 x 0.79422) /0.81639
= 92.420
-Absolute ethanol content (mass%) = 95 vol% ethanol content (mass%) x 92.420 / 100 Formula 2
In addition, the content (mass%) converted into absolute ethanol when using 95.3 vol% ethanol can be obtained by the following formula 3 and formula 4.
-Mass% of ethanol = 95.3 x 0.79422 / 0.81639
= 92.712 Formula 3
-Absolute ethanol content (mass%) = 95.3 vol% ethanol content (mass%) x 92.712 / 100 Formula 4

<(C) Sodium hyaluronate>
The component (C) sodium hyaluronate is contained in order to improve the non-stickiness, the softness of the hair on the top of the head, the moisturizing effect of the scalp, and the low temperature stability.

The component (C) sodium hyaluronate has a viscosity average molecular weight of 800,000 to 2,700,000 from the viewpoints of no stickiness, softness of hair on the top of the head, moisturizing effect of the scalp, and low temperature stability. 1,000,000 to 2,000,000 are preferable, and 1,300,000 to 2,000,000 are more preferable.
When the viscosity average molecular weight is less than 800,000, the moisturizing effect of the scalp is insufficient, and when it exceeds 2,700,000, it becomes difficult to obtain.

Here, the viscosity average molecular weight of the sodium hyaluronate can be measured, for example, by the following method (see Laurent, TC et al, Biophys Acta, 42, 476 (1960)).
0.04 g of a sample is weighed accurately, 0.2 mol / L sodium chloride test solution is added and dissolved to make 100 mL, and a sample solution is obtained. Take this solution 8mL exactly Ubbelohde viscometer (kinematic viscosity range ^{1mm 2 / s~5mm 2 / s)} , measuring the flow time at 25 ℃ ± 0.1 ℃. Further, 2 mL of 0.2 mol / L sodium chloride test solution is accurately added and mixed, and then the flow time is measured. Further, this operation is repeated twice, and sample solutions having four concentrations are measured. The specific viscosity and the reduced viscosity for each concentration are calculated by the following formulas 5 and 6. Next, a graph is created with the reduced viscosity as the vertical axis and the concentration (g / L) converted to the corresponding dried product as the horizontal axis, and the intrinsic viscosity is obtained from the extension of the straight line connecting the points and the intersection of the vertical axis. From the obtained intrinsic viscosity, the viscosity average molecular weight is calculated using the following Laurent formula.
<Laurent's formula>
“Intrinsic viscosity” (cm ³ /g)×100=0.036×M ^0.78 (where M represents the viscosity average molecular weight)

The sodium hyaluronate is not particularly limited, and may be a fermented product or a natural product extracted and purified from chicken cassava.
There is no restriction | limiting in particular as sodium hyaluronate whose viscosity average molecular weight of said (C) component is 800,000-2,700,000, According to the objective, it can select suitably, For example, viscosity average molecular weight 800,000 ˜1,170,000 biohyaluronic acid sodium salt HA9N (manufactured by Shiseido Co., Ltd.), viscosity average molecular weight 1,000,000 to 1,400,000 hyaluronic acid FCH-120 (manufactured by Kikkoman Biochemifa Co., Ltd.), viscosity average Sodium biohyaluronate HA12N (manufactured by Shiseido Co., Ltd.) having a molecular weight of 1,100,000 to 1,600,000, 1% aqueous solution of sodium biohyaluronate having a viscosity average molecular weight of 1,370,000 to 1,530,000 (PE) N (manufactured by Shiseido Co., Ltd.), viscosity average molecular weight 1,400,000-1, Hyaluronic acid FCH-150 of 00,000 (manufactured by Kikkoman Biochemifa Co., Ltd.), hyaluronic acid FCH-200 having a viscosity average molecular weight of 1,800,000-2,200,000 (manufactured by Kikkoman Biochemifa Co., Ltd.), viscosity average molecular weight Examples include 1,900,000 to 2,700,000 biohyaluronate sodium HA20N (manufactured by Shiseido Co., Ltd.). These may be used alone or in combination of two or more.
Among these, sodium hyaluronate HA9N (manufactured by Shiseido Co., Ltd.) having a viscosity average molecular weight of 800,000 to 1,170,000, hyaluronic acid FCH-120 having a viscosity average molecular weight of 1,000,000 to 1,400,000 ( Kikkoman Biochemifa Co., Ltd.) and sodium biohyaluronate HA20N (manufactured by Shiseido Co., Ltd.) having a viscosity average molecular weight of 1,900,000-2,700,000 are preferred.

  The content of the component (C) sodium hyaluronate is based on the total amount of the hair restorer composition from the viewpoints of no stickiness, fluffy hair on the top of the head, moisturizing effect on the scalp, and low temperature stability. 0.00001% by mass to 0.001% by mass, preferably 0.0001% by mass to 0.0008% by mass. When the content is less than 0.00001% by mass, the moisturizing effect of the scalp decreases, and when it exceeds 0.001% by mass, the low temperature stability, no stickiness, and the softness of the hair on the top of the head decrease. To do.

<(D) Polyethylene glycol>
The polyethylene glycol as the component (D) is contained in order to improve the non-stickiness, the softness of the hair on the top of the head, the moisturizing effect of the scalp, and the low temperature stability.

  The polyethylene glycol as the component (D) has an average molecular weight of 190 to 420 in terms of lack of stickiness, softness of hair on the top of the head, moisturizing effect on the scalp, and low temperature stability.

The average molecular weight of the polyethylene glycol as the component (D) can be measured according to an average molecular weight test of polyethylene glycol 200 described in the Quasi-drug Raw Material Standard 2006 (Pharmaceutical Daily).
First, about 0.8 g of polyethylene glycol is accurately weighed using a precision balance, placed in an about 200 mL pressure-resistant stopper bottle, about 25 mL of pyridine is added, heated to dissolve, and then allowed to cool. 42 g of phthalic anhydride is accurately weighed into 300 mL of freshly distilled pyridine, added to a light-stoppered bottle with a capacity of 1 L, shaken vigorously, and then left to stand for 16 hours or more. 25 mL of this solution is accurately weighed, added to the pressure-proof stopper bottle, sealed, wrapped in a pressure-resistant stopper bottle with a strong cloth, and the liquid in the bottle is preliminarily heated to 98 ° C. ± 2 ° C. Put it in the liquid. After heating at 98 ° C. ± 2 ° C. for 30 minutes, the bottle is taken out from the water bath and allowed to cool to room temperature (1 ° C. to 30 ° C., the same applies hereinafter). Next, exactly 50 mL of 0.5 mol / L sodium hydroxide solution is added and this solution is titrated with 0.5 mol / L sodium hydroxide solution. At this time, 5 drops of phenolphthalein / pyridine solution (1 → 100) is used as an indicator. However, the end point of titration is when the liquid continues to exhibit a pale red color for 15 seconds. Perform a blank test in the same manner.
The obtained value is applied to the following formula 7, and the average molecular weight is calculated.
[Average molecular weight]
Average molecular weight = [Amount of sample (g) × 4,000] / (ab) Equation 7
a: Consumption of the 0.5 mol / L sodium hydroxide solution in the blank test (mL)
b: Consumption of the 0.5 mol / L sodium hydroxide solution in the sample test (mL)
In the case of polyethylene glycol having an average molecular weight of 280 to 420, the weighed amount is about 1.5 g, and the other methods are the same as those for polyethylene glycol having an average molecular weight of 190 to 210.

  Examples of polyethylene glycol having an average molecular weight of component (D) of 190 to 420 include polyethylene glycol 200 having an average molecular weight of 190 to 210 (trade name: PEG 200, manufactured by Aoki Yushi Kogyo Co., Ltd.), average molecular weight of 280 to 320. Polyethylene glycol 300 (trade name: PEG 300, manufactured by Aoki Oil & Fat Co., Ltd.), polyethylene glycol 400 (trade name: PEG 400, manufactured by Aoki Oil & Fat Co., Ltd.) having an average molecular weight of 380 to 420, and the like. These may be used alone or in combination of two or more. Among these, polyethylene glycol 300 having an average molecular weight of 280 to 320 is preferable from the viewpoints of non-stickiness, softness of hair at the top of the head, moisturizing effect on the scalp, and low temperature stability.

  As the content of the polyethylene glycol of the component (D), from the viewpoint of no stickiness, softness of hair on the top of the head, moisturizing effect of the scalp, and low temperature stability, the total amount of the hair restorer composition is as follows: 1 mass% to 5 mass%, preferably 2 mass% to 4 mass%. When the content is less than 1% by mass, the moisturizing effect and low-temperature stability of the scalp are lowered, and when it exceeds 5% by mass, the non-stickiness and the softness of the hair on the top of the head are lowered.

[Mass ratio (D / C)]
As the mass ratio (D / C) of the content (mass%) of the component (C) and the content (mass%) of the component (D), there is no stickiness and the softness of the hair on the top of the head From the viewpoint of improving the moisturizing effect of the scalp, it is 2,000 to 400,000, and preferably 10,000 to 300,000. When the mass ratio is less than 2,000, the moisturizing effect of the scalp is lowered, and when it exceeds 400,000, the non-stickiness, the softness of the hair on the top of the head, and the moisturizing effect of the scalp are lowered.

<(E) Coleus Forskoli extract>
The (E) component Coleus forskori extract is contained in order to improve the non-stickiness, the softness of the hair on the top of the head, and the moisturizing effect of the scalp.

  There is no restriction | limiting in particular as said Coleus forskori extract of the said (E) component, According to the objective, it can select suitably, A commercial item can also be used. Examples of the commercially available product include Coleus extract (trade name: Coleus extract, manufactured by Toyoda Fragrance Co., Ltd., pure extract 8.5%, 95% ethanol 91.5%) and the like.

  As content of the said (E) component Coleus forskori extract, 0.01 mass%-5 mass% are preferable with respect to the whole quantity of the said hair restorer composition, and 0.1 mass%-3 mass% are more. Preferably, the pure content of Coleus forskori extract is preferably 0.00003% by mass to 0.015% by mass, and more preferably 0.0003% by mass to 0.009% by mass. When the content is less than 0.01% by mass (0.00003% by mass as the pure content of Coleus forskori extract), the moisturizing effect of the scalp may be insufficient. When the extract content exceeds 0.015% by mass), the non-stickiness and the softness of the hair on the top of the head may be reduced.

<Other ingredients>
In addition to the components (A) to (E), other components may be added to the hair-restoring agent composition of the present invention as necessary within a range that does not impair the effects of the present invention. it can.

  The other components are not particularly limited and may be appropriately selected depending on the purpose. For example, hydrocarbon oils, ester oils, waxes, silicone oils, anionic surfactants, amphoteric surfactants, nonions Surfactants, semipolar surfactants, ultraviolet absorbers, water-soluble polymer compounds other than the component (C), thickeners, polyhydric alcohols other than the component (D), organic salts, sugars, lower alcohols, etc. Anti-dandruff agents such as piroctone olamine and zinc pyrithione, anti-inflammatory agents such as dipotassium glycyrrhizinate, parabens, preservatives such as caisson CG, pH adjusting agents, pearling agents such as ethylene glycol difatty acid esters, and emulsion Agents, fresheners, vitamins, cosmetic ingredients, fragrances, powders, and other ingredients, such as hydrotropes, vitamins , Volatile oil, hydrophobic solvents, dilution solvents, pigments, etc. perfumes. These may be used alone or in combination of two or more.

-Manufacturing method-
There is no restriction | limiting in particular as a manufacturing method of the hair restorer composition of this invention, According to the objective, it can select suitably, For example, the said (A) component, the said (B) component, the said (C) component, the said, It can manufacture by mixing (D) component, Preferably said (E) component and also the said other component as needed.

-PH-
There is no restriction | limiting in particular as pH of the said hair restorer composition, Although it can select suitably according to the objective, 4.0-8.0 are preferable and 5.0-7.0 are more preferable. When the pH is less than 4.0, the retention of the hair restorer composition on the scalp and skin may deteriorate, and when it exceeds 8.0, the scalp and skin may be stimulated. . On the other hand, when the pH is within the preferred range, the hair-recovery composition has good retention in the scalp and skin, and is advantageous in that it does not irritate the scalp and skin.
The pH can be measured using a pH meter (HM-30G, manufactured by Toa DKK Co., Ltd.).
The pH of the hair restorer composition can be adjusted using, for example, a desired pH adjuster. The pH adjuster is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include citric acid, succinic acid, 2-amino-2-methyl-1-propanol, monoethanolamine and the like. It is done.

-Container-
There is no restriction | limiting in particular as a container filled with the hair restorer composition of this invention, According to the objective, it can select suitably, For example, a dispenser container, a squeeze container, a laminate film container, a dropper container, a bottle container etc. are mentioned. It is done. As the bottle material, polyethylene, polypropylene, polyethylene terephthalate, polystyrene, polyvinyl chloride, ethylene-vinyl alcohol resin, acrylonitrile / styrene resin, ABS resin, polyamide, glass, etc. can be used in a single layer or in combination of two or more layers. In particular, polyethylene is preferred.

-Use-
The hair restorer composition of the present invention has good low-temperature stability and is excellent in hair loss inhibiting effect, hair growth promoting effect, no stickiness, softness of hair on the top of the head, and moisturizing effect on the scalp. It can be suitably used for agents, hair nourishing agents, scalp cosmetics and the like.

  Hereinafter, the present invention will be described more specifically based on examples and comparative examples, but the present invention is not limited to the following examples.

(Examples 1-27 and Comparative Examples 1-15)
Hair growth compositions having the compositions and contents shown in Tables 1 to 11 below were prepared by a conventional method. Specifically, it adjusted with the following method.
-Preparation of hair restorer composition-
Based on the composition (mass%) shown in Tables 1 to 11, (A) component or (A ′) component, (D) component or (D ′) component, and common components in (B) component ethanol Were added in order and dissolved in water, and the components (C) or (C ′) were added little by little and stirred at room temperature (20 ° C.) to 40 ° C. using a stirrer. The hair restorer compositions of Comparative Examples 1-15 were prepared.
When each obtained hair restorer composition was measured for pH at 25 ° C using a pH meter (manufactured by Toa DKK Corporation, HM-30G), the pH of Examples 1 to 27 and Comparative Examples 1 to 15 was any. Was also 5.5.
In addition, about (B) component, since the ethanol content of the used raw material was 95.3 volume%, content as absolute ethanol was computed using the following formula | equation. In addition, content of the said (B) component is a total content of the absolute ethanol containing the ethanol brought in from a common component.
-Mass% of ethanol = 95.3 x 0.79422 / 0.81639
= 92.712
-Absolute ethanol content (mass%) = 95.3 vol% ethanol content (mass%) x 92.712 / 100
In addition, the seaweed extract and the ethanol of the Coleus extract were converted as 95.0% by volume. About content, the 4th decimal place was rounded off and the 3rd decimal place was described. However, for Examples 54 and 55, the sixth digit after the decimal point was rounded to the fifth digit according to the number of digits of the amount of Coleus extract.
-Mass% of ethanol = 95.0 x 0.79422 / 0.81639
= 92.420
-Absolute ethanol content (mass%) = 95.0 vol% ethanol content (mass%) x 92.420 / 100
About components other than the said (B) component, content converted into the pure part was shown.

Next, with respect to each hair restorer composition obtained, “hair loss suppressing effect”, “hair growth promoting effect”, “no stickiness”, “softness of hair on top of head”, “scalp” The “moisturizing effect” and “low temperature stability” were evaluated. The results are shown in Tables 1 to 11 below. In Comparative Example 4, since the component (B) ethanol was not contained, the component (A) was not dissolved, and thus could not be evaluated in all evaluation items.
Moreover, "total (mass%) of (B) component" in the following table | surface represents the total amount of all the ethanol pure components contained in a hair restorer composition.

<Hair loss inhibiting effect and hair growth promoting effect>
For 40 general women in their 50s to 60s, 1.5 ml of hair restoration compositions of Examples 1 to 27 and Comparative Examples 1 to 15 were applied twice a day to the entire scalp for 1 month. After continuous use, the number of hair loss after use was observed compared to before continuous use, and the “hair loss inhibiting effect” was evaluated according to the following evaluation criteria. Similarly, the amount of hair was observed, and the “hair growth promoting effect” was evaluated according to the following evaluation criteria. In addition, if the evaluation score is 3 points or more, the “hair loss suppressing effect” and the “hair growth promoting effect” are good.
[Evaluation criteria for hair loss suppression effect]
5 points: 36 or more out of 40 responded that hair loss was reduced 4 points: 28 to 35 out of 40 responded that hair loss was reduced 3 points: 20 to 27 out of 40 persons The following responded that hair loss had decreased 2 points: 12 to 19 out of 40 responded that hair loss had decreased 1 point: 11 or less out of 40 responded that hair loss had decreased [ Evaluation criteria for hair growth promoting effect]
5 points: 36 or more out of 40 responded that there was a feeling that hair increased 4 points: 28 or more and 35 or less out of 40 responded that there was a feeling that hair increased 3 points: 40 20 to 27 of them answered that they had increased hair 2 points: 12 to 19 of 40 people answered that they had increased hair 1 point: 11 of 40 Less than the person answered that there was a feeling of increased hair

<No stickiness and softness of hair on top of head>
About 30 general women in their 40s to 60s, after the hair was washed with shampoo (trade name: Plant Story Shampoo H1, manufactured by Lion Corporation), the hair restorer compositions of Examples 1-27 and Comparative Examples 1-15. 5 mL was applied to the entire scalp. This procedure was repeated for 3 days and then evaluated according to the following evaluation criteria. When the evaluation score is 3 points or more, “no stickiness” and “softness of hair on the top of the head” are good.
[Evaluation criteria for lack of stickiness and softness of hair on top of head]
5 points: 24 or more out of 30 responded good 4 points: 18 to 23 out of 30 responded good 3 points: 12 to 17 out of 30 17 or less 2 points: 6 to 11 out of 30 responded that they were good 1 point: 5 or less of 30 responded that they were good

<Moisturizing effect of scalp>
About 4 test subjects, after acclimatizing in 25 degreeC and 40% RH environment, the stratum corneum moisture content was measured (initial value). Next, 1.5 mL of the hair restorer composition of Examples 1 to 27 and Comparative Examples 1 to 15 was applied, allowed to stand for 5 minutes, and then the stratum corneum moisture content was measured again. For each of the four subjects, the rate of increase in the amount of moisture (%) after application was determined relative to the amount of moisture in the stratum corneum (initial value) before application, and the average rate of increase for the four subjects was calculated. evaluated. For the measurement, a stratum corneum moisture meter (apparatus name: stratum corneum film thickness moisture system ASA-M2, manufactured by Asahi Biomed Co., Ltd.) was used. The higher the average increase rate, the higher the amount of water. If the evaluation score is 3 points or more, the “scalp moisturizing effect” is good.
[Evaluation criteria]
5 points: Compared to the initial value, the average increase rate is 160% or more 4 points: Compared to the initial value, the average increase rate is 140% or more and less than 160% 3 points: Compared to the initial value, the average increase rate is 120% More than 140% less than 2 points: The average increase rate is 100% or more and less than 120% compared to the initial value 1 point: The average increase rate is less than 100% compared with the initial value

<Low temperature stability>
45 mL of the prepared hair restorer composition was filled into a 50 mL glass vial (trade name: SV-50A, manufactured by Nidec Rika Glass Co., Ltd.), stored in a thermostatic bath at -5 ° C for 1 month, and then kept at 20 ° C. The external appearance of the solution was visually observed and evaluated according to the following evaluation criteria. In addition, the evaluation was △ or higher as a pass level.
[Evaluation criteria]
○: No orientation (precipitate) is generated. Δ: Orientation is generated, but re-dissolves when left at 20 ° C. for 20 minutes. X: Orientation occurs and does not re-dissolve.

(Examples 28 to 58)
In Example 1, hair restorer compositions of Examples 28 to 58 were prepared in the same manner as in Example 1 except that the compositions and contents shown in Tables 12 to 19 below were changed.

  Next, in the same manner as in Example 1, the hair loss suppressing effect, the hair growth promoting effect, the absence of stickiness, the softness of the hair on the top of the head, the moisturizing effect of the scalp, and the low temperature stability were evaluated. The results are shown in Tables 12 to 19 below.

  The raw materials used in the above Examples and Comparative Examples are as shown in Table 20 below.

  The hair restorer composition of the present invention has good low-temperature stability and is excellent in hair loss inhibiting effect, hair growth promoting effect, no stickiness, softness of hair on the top of the head, and moisturizing effect on the scalp. It is suitably used for agents, hair nourishing agents, scalp cosmetics and the like.

Claims (2)

(A) 0.1 mass% to 5 mass% of at least one hair restoring active ingredient selected from 6-benzylaminopurine, glyceride pentadecanoate, and minoxidil;
(B) 55% by mass to 85% by mass of ethanol;
(C) 0.00001% by mass to 0.001% by mass of sodium hyaluronate having a viscosity average molecular weight of 800,000 to 2,700,000,
(D) 1 to 5% by mass of polyethylene glycol having an average molecular weight of 190 to 420,
The mass ratio (D / C) of the content (mass%) of the component (C) and the content (mass%) of the component (D) is 2,000 to 400,000. A hair restorer composition.   (E) The hair-restoring agent composition according to claim 1, further comprising Coleus forskori extract.