JP2018058813A - Antisepsis antimicrobial agent for cosmetics - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide antisepsis antimicrobial agents for cosmetics exerting antisepsis antimicrobial effect higher than conventional antisepsis antimicrobial agents.SOLUTION: An antisepsis antimicrobial agent for cosmetics comprising a copolymer is provided, characterized by that the copolymer has a structural unit (a) derived from an amino group-containing monomer (A), and a structural unit (b) derived from a hydrophobic monomer (B), the weight average molecular weight is 4000 to 200,000, and the amino group-containing monomer (A) is a predetermined structure (but excluding ethylene, and polyalkylene glycol monomer represented by a predetermined structure, from monomer components).SELECTED DRAWING: None

Description

The present invention relates to a preservative antibacterial agent for cosmetics. More specifically, the present invention relates to a preservative antibacterial agent for cosmetics useful for skin cosmetics, skin external preparations, hair cosmetics and the like.

2. Description of the Related Art Conventionally, parabens, benzoic acid and salts thereof, salicylic acid and salts thereof, and the like are used as antiseptic fungicides in human body compositions such as cosmetics, pharmaceuticals, quasi drugs, and foods.
However, the above-mentioned conventional antiseptic disinfectant has a drawback that the use concentration range is easily limited because of its low safety such as high skin irritation. For example, the use restriction concentration of paraben and benzoate is 1%. The limit concentration of benzoic acid and salicylic acid is 0.2%.
In recent years, an increasing number of people have an allergic reaction to these antiseptic disinfectants, so the safety consciousness has increased and cosmetics with no or no preservative antiseptics have been added. There is an increasing demand for coating compositions.
Therefore, various attempts have been made to overcome the disadvantages of conventional antiseptics and to reduce the amount of antiseptics used by searching for highly safe antibacterial substances and increasing the effectiveness of antiseptics. . For example, a technique using 1,2-alkanediol, which is safer for the human body (see Patent Document 1), a technique using glycerol monoalkyl ether (see Patent Document 2), a technique using ethyl 4-hydroxyphenylacetate (Patent Document) 3)) has been reported.

JP 2010-13359 A Special table 2003-535116 gazette JP 2008-1000092 A

As described above, conventional antiseptic antibacterial agents such as 1,2-alkanediol, glycerol monoalkyl ether and ethyl 4-hydroxyphenylacetate can provide a certain level of antibacterial antibacterial effect but exhibit higher antiseptic antibacterial effect. Development of antiseptic antibacterial agents is desired.

This invention is made | formed in view of the said present condition, and aims at providing the antiseptic antibacterial agent for cosmetics which exhibits the antiseptic antibacterial effect higher than the conventional antiseptic antibacterial agent.

As a result of various studies on antiseptic antibacterial agents for cosmetics, the present inventors have found that a structural unit derived from an amino group-containing monomer (A) having a specific structure (a) and a structural unit derived from a hydrophobic monomer (B) It is found that a copolymer having (b) and a weight average molecular weight of 4,000 to 200,000 exhibits a higher antiseptic antibacterial effect than a conventional antiseptic antibacterial agent, and can solve the above-mentioned problems brilliantly. The present inventors have arrived at the present invention by conceiving what can be done.

（式（４）〜（６）中、Ｒ^６〜Ｒ^８は、同一又は異なって、水素原子又は炭素数１〜５のアルキル基を表す。Ｘは、直接結合又は２価の連結基を表す。式（４）及び（５）中、Ｒ^１、Ｒ^２は、同一又は異なって、炭素数１〜１２の炭化水素基を表す。式（６）中、Ｒ^３〜Ｒ^５は、同一又は異なって、炭素数１〜１２の炭化水素基を表す。Ｙ⁻は、陰イオンを表す。）で表される構造である（但し、単量体成分からエチレン、及び、下記式；

（式中、Ｒ^１１は、水素原子又はメチル基を表す。Ｒ^１２は、水素原子又は炭素数１〜２２のアルキル基又はアルケニル基を表す。ＡＯは、同一又は異なって、オキシエチレン基又はオキシプロピレン基を表す。ｐは、オキシアルキレン基の平均付加モル数を表し、１〜５０の数である。）で表される単量体を除く。）共重合体を含む化粧料用防腐抗菌剤である。
以下に本発明を詳述する。
なお、以下において記載する本発明の個々の好ましい形態を２つ以上組み合わせたものもまた、本発明の好ましい形態である。 That is, the present invention has a structural unit (a) derived from the amino group-containing monomer (A) and a structural unit (b) derived from the hydrophobic monomer (B), and has a weight average molecular weight of 4000 to 200,000. And
The amino group-containing monomer (A) is represented by the following formulas (4) to (6);

(In Formula (4)-(6), R < ⁶ > -R < ⁸ > is the same or different, and represents a hydrogen atom or a C1-C5 alkyl group. X represents a direct bond or a bivalent coupling group. In formulas (4) and (5), R ¹ and R ² are the same or different and represent a hydrocarbon group having 1 to 12 carbon atoms, and in formula (6), R ^{3 to} R ⁵ are the same or . differently, .Y representing a hydrocarbon group having 1 to 12 carbon atoms ^- is a structure represented by representing an anion) (where ethylene from monomer components, and the following formula;

(In the formula, R ¹¹ represents a hydrogen atom or a methyl group. R ¹² represents a hydrogen atom or an alkyl group or an alkenyl group having 1 to 22 carbon atoms. AO is the same or different and represents an oxyethylene group or an oxy group. Represents a propylene group, p represents the average number of moles added of the oxyalkylene group, and is a number of 1 to 50). ) A preservative antibacterial agent for cosmetics containing a copolymer.
The present invention is described in detail below.
A combination of two or more preferred embodiments of the present invention described below is also a preferred embodiment of the present invention.

The cosmetics in the present invention mean cosmetics, pharmaceuticals, and quasi-drugs that are directly applied to the human skin. Cosmetics include skin cosmetics, skin external preparations, hair cosmetics, and the like.
The antiseptic antibacterial agent for cosmetics in the present invention refers to an agent used for cosmetics and having antiseptic performance and / or antibacterial performance. Antiseptic performance is the ability to prevent the invasion, growth and proliferation of microorganisms and prevent rot and fermentation. Antibacterial performance refers to sterilization (killing microorganisms) and bacteriostatic (suppressing the growth of microorganisms). ) Performance such as sterilization, disinfection, sterilization, sterilization, and mold prevention. The target microorganisms are bacteria and fungi.

Examples of the bacterium include Gram-negative bacteria such as Escherichia coli, Pseudomonas aeruginosa, Salmonella, Moraxella, Legionella, and Gram-positive bacteria such as Staphylococcus aureus and Clostridium bacteria. Examples of the fungi include yeasts such as Candida, Rhodotorula, and baker's yeast; molds such as red mold and black mold (black mold and black mold).

The antiseptic antibacterial agent for cosmetics of the present invention (hereinafter also simply referred to as the antiseptic antibacterial agent of the present invention) is a co-polymer having a structural unit derived from an amino group-containing monomer and a structural unit derived from a hydrophobic monomer. Includes coalescence. The reason why antiseptic and antibacterial properties are exhibited by including such a copolymer is presumed as follows. When the antiseptic antibacterial agent for cosmetics of the present invention is allowed to act on microorganisms, the amino group derived from the amino group-containing monomer of the copolymer is adsorbed on the surface of the microorganism having a negative charge. Furthermore, the hydrophobic group of the copolymer shows affinity with the cell membrane part, and by interacting with the cell membrane, the interaction between lipids constituting the cell membrane is broken and / or bound to the membrane. By inhibiting the function of protein or the like, it is presumed that the cell is destroyed and / or the physiological activity of the cell is inhibited and the microorganism is killed.
Since the copolymer is a polymer, it is safer than conventional ones made of low molecular weight compounds, and since it is water-soluble, there are few restrictions on blending into cosmetics.
Furthermore, the antiseptic antibacterial agent for cosmetics of the present invention has an effect of emulsifying the cosmetics and an effect of increasing the viscosity of the cosmetics when blended in the cosmetics, and also has an effect as an emulsifier and a thickener. It can be demonstrated.

The copolymer contained in the antiseptic antibacterial agent for cosmetics of the present invention has a structural unit (a) derived from the amino group-containing monomer (A). The amino group-containing monomer includes an ethylenically unsaturated group and the following formula (1);

(Wherein R ¹ and R ² are the same or different and each represents a hydrogen atom or a hydrocarbon group having 1 to 12 carbon atoms) or a ^primary to tertiary amino group represented by It is a monomer having a neutralized product of a quaternary amino group with an acid or a quaternary ammonium base.
The hydrocarbon group may have a chain structure or a ring structure, but preferably has a chain structure. When the hydrocarbon group has a chain structure, it may be linear or branched.
As said hydrocarbon group, an alkyl group, an alkenyl group, and an aryl group are preferable, More preferably, they are an alkyl group and an alkenyl group, More preferably, it is an alkyl group.
Moreover, as carbon number of the said hydrocarbon group, 1-10 are preferable, More preferably, it is 1-8, More preferably, it is 1-5, Most preferably, it is 1-2.
At least one of R ¹ and R ² is preferably a hydrocarbon group having 1 to 12 carbon atoms, and more preferably both R ¹ and R ² are hydrocarbon groups. That is, among the primary to tertiary amino groups, tertiary amino groups are preferred.

Examples of the primary to tertiary amino groups include the following formula (2):

(Wherein R ¹ and R ² are the same or different and each represents a hydrogen atom or a hydrocarbon group having 1 to 12 carbon atoms. Y ⁻ represents an anion). preferable. Specific examples and preferred forms of the hydrocarbon group are as described above.

As said quaternary ammonium base, following formula (3);

(In formula, R < ³ > -R < ⁵ > is the same or different and represents a C1-C12 hydrocarbon group. Y < ^- > represents an anion.). Specific examples and preferred forms of the hydrocarbon group are as described above.
The hydrocarbon group having 1 to 12 carbon atoms is preferably an alkyl group having 1 to 12 carbon atoms or an alkenyl group having 2 to 12 carbon atoms.
As carbon number of R < ³ > -R < ⁵ >, More preferably, it is 1-10, More preferably, it is 1-7, Most preferably, it is 1-5.
The hydrocarbon group for R ^{3 to} R ⁵ is most preferably a methyl group or an ethyl group.

Y ⁻ in the above formulas (2) and (3) is not particularly limited. For example, halide ions such as chlorine ion, bromine ion and iodine ion; alkyl sulfate ions such as methyl sulfate ion; organic acids such as acetate ion And the like.
Y ⁻ in the above formula (2) is preferably an organic acid ion.
Y ⁻ in the above formula (3) is preferably a halide ion or an alkyl sulfate ion.

Among the amino groups, among the primary to tertiary amino groups, neutralized products of acids of the primary to tertiary amino groups and quaternary ammonium bases, tertiary amino groups and acids of tertiary amino groups are used. Neutralized products or quaternary ammonium bases are preferred. The neutralized product of the tertiary amino group or the tertiary amino group with an acid is preferably a dimethylamino group, a diethylamino group or a neutralized product thereof with an acid such as hydrochloric acid or acetic acid.

As said amino group containing monomer (A), following formula (4)-(6);

(In Formula (4)-(6), R < ⁶ > -R < ⁸ > is the same or different, and represents a hydrogen atom or a C1-C5 alkyl group. X represents a direct bond or a bivalent coupling group. In formulas (4) and (5), R ¹ and R ² are the same or different and represent a hydrocarbon group having 1 to 12 carbon atoms, and in formula (6), R ^{3 to} R ⁵ are the same or Differently, it represents a hydrocarbon group having 1 to 12 carbon atoms, and Y ⁻ represents an anion.

The alkyl group having 1 to 5 carbon atoms in R ⁸ is preferably a methyl group. R ⁸ is preferably a hydrogen atom or a methyl group. From the viewpoint of antibacterial properties and hydrolysis resistance, R ⁸ is more preferably a methyl group.
R ⁶ and R ⁷ are preferably hydrogen atoms.

Although it does not restrict | limit especially as a bivalent coupling group in the said Formula (4) and (5), For example, following formula (7);

(Wherein m represents an integer of 0 to 12), the following formula (8);

(Wherein, l represents an integer of 0 to 4) and the following formula (9);

(Wherein, k represents an integer of 1 to 10).

As a bivalent coupling group in the said Formula (6), the structure represented by the said Formula (7)-(9) and a C1-C12 alkylene group are mentioned.
M in the above formula (7) is preferably 1 to 8, and more preferably 1 to 5.
K in the formula (9) is preferably 1 to 8, more preferably 1 to 5.

Specific examples of the amino group-containing monomer (A) include N, N-dimethylaminoethyl (meth) acrylate, N, N-diethylaminoethyl (meth) acrylate, and N, N-dimethylaminopropyl (meth). N, N-dialkylamino group-containing (meth) acrylates such as acrylate, N, N-diethylaminopropyl (meth) acrylate and the like, monomers obtained by adding a quaternizing agent to the above monomers, or acids such as hydrochloric acid and acetic acid. Neutralized product: N, N-dimethylaminoethyl (meth) acrylamide, N, N-diethylaminoethyl (meth) acrylamide, N, N-dimethylaminopropyl (meth) acrylamide, N, N-diethylaminopropyl (meth) acrylamide, etc. N, N-dialkylamino group-containing (meth) acrylamides Monomers obtained by adding a quaternizing agent to the above monomers or neutralized products thereof with acids such as hydrochloric acid and acetic acid; monomethylaminoethyl (meth) acrylate, monoethylaminoethyl (meth) acrylate, monomethylaminopropyl (meth) Monoalkylamino group-containing (meth) acrylates such as acrylate, monoethylaminopropyl (meth) acrylate, 2- (tert-butylamino) ethyl (meth) acrylate, and neutralized products thereof with acids such as hydrochloric acid and acetic acid Monoalkylamino group-containing (meth) acrylamides such as monomethylaminoethyl (meth) acrylamide, monoethylaminoethyl (meth) acrylamide, monomethylaminopropyl (meth) acrylamide, monoethylaminopropyl (meth) acrylamide, and the like; Neutralized products by acid such as hydrochloric acid and acetic acid; (meth) acrylic acid-2-aminoethyl and other (meth) acrylic acid and alkanolamine esters and neutralized products by acid such as hydrochloric acid and acetic acid; N , N-diallylmethylamine and a monomer obtained by adding a quaternizing agent thereto, or a neutralized product thereof with an acid such as hydrochloric acid or acetic acid; an allylamine or a neutralized product thereof with an acid such as hydrochloric acid or acetic acid; 1-allyloxy Unsaturated monomers having a cyclic ether-containing group having 2 to 8 carbon atoms such as -3-dibutylamino-2-ol, 1-allyloxy-3-diethanolamino-2-ol, and amine compounds having 1 to 24 carbon atoms And a monomer obtained by adding a quaternizing agent thereto or a neutralized product thereof with an acid such as hydrochloric acid or acetic acid.

The amine compound having 1 to 24 carbon atoms is not particularly limited as long as it can react with the cyclic ether structure of an unsaturated monomer having an amino group and a cyclic ether-containing group having 2 to 8 carbon atoms. 1-20 are preferable and, as for carbon number of a C1-C24 amine compound, 1-16 are more preferable. Examples of the amine compound having 1 to 24 carbon atoms include primary amines and secondary amines, such as (di) alkylamines having 1 to 24 carbon atoms, (di) alkanolamines having 1 to 24 carbon atoms, Examples thereof include alkyl alkanolamines having 1 to 24 carbon atoms.
Examples of the (di) alkylamine having 1 to 24 carbon atoms include methylamine, ethylamine, propylamine, butylamine, dimethylamine, diethylamine, dipropylamine, dibutylamine, pentylamine, dipentylamine, hexylamine, dihexylamine, heptylamine , Diheptylamine, octylamine, dioctylamine, dodecylamine, didodecylamine and the like are preferable.
As the (di) alkanolamine having 1 to 24 carbon atoms, methanolamine, ethanolamine, propanolamine, butanolamine, dimethanolamine, diethanolamine, dipropanolamine, dibutanolamine, hexanolamine and the like are preferable.
As the alkyl alkanolamine having 1 to 24 carbon atoms, methylethanolamine or the like is preferable.

In the amino group-containing monomer (A), R ⁸ in the formulas (4) to (6) is preferably a methyl group, and X is preferably a structure represented by the formula (7).

The amino group-containing monomer (A) is preferably an N, N-dialkylamino group-containing (meth) acrylate and a neutralized product thereof with an acid such as hydrochloric acid or acetic acid or a quaternizing agent added thereto. Monomers, N, N-dialkylamino group-containing (meth) acrylamides and their neutralized products with acids such as hydrochloric acid and acetic acid, and monomers obtained by adding a quaternizing agent to these, particularly N, N-dimethylamino Neutralized products such as ethyl (meth) acrylate, N, N-diethylaminoethyl (meth) acrylate, N, N-dimethylaminopropyl (meth) acrylamide, and acids such as hydrochloric acid and acetic acid, and quaternizing agents are added to these. More preferred is a monomer that has been allowed to react.
The quaternizing agent is not particularly limited, but alkyl halides such as methyl chloride, ethyl chloride, methyl bromide and methyl iodide; dimethyl sulfate, diethyl sulfate, di-n-propyl sulfate and the like. Common alkylating agents such as alkyl sulfuric acid may be mentioned.
The amino group-containing monomer may be a tertiary amine or a quaternary ammonium cation, but the tertiary amine exhibits higher antibacterial properties against gram-negative bacteria and quaternary ammonium cation against gram-positive bacteria. become.

The copolymer of the present invention has a structural unit (b) derived from a hydrophobic monomer (B), and the hydrophobic monomer (B) is a homopolymer obtained by homopolymerization. The solubility parameter of (homopolymer) is 15 or less. In addition, even if a solubility parameter is 15 or less, what has an amino group shall be contained in an amino group containing monomer (A).
Here, the solubility parameter is a value calculated by the method described on pages 147 to 154 of “POLYMER ENGINEERING AND SCIENCE” (1974, Vol. 14, No. 2).
The method is outlined below. The solubility parameter (δ) (cal / cm ³ ) ^1/2 of the homopolymer is based on the evaporation energy (Δei) and molar volume (Δvi) of the structural unit forming the polymer: It is calculated by the following calculation method.
δ = (Δei / Δvi) ^1/2 (cal / cm ³ ) ^1/2

If the solubility parameter for the homopolymer obtained by polymerizing the hydrophobic monomer alone is 15 or less, the copolymer of the present invention has sufficient hydrophobicity, and the Since the affinity for the cell membrane is improved and the interaction with the cell membrane is increased, the physiological activity of the cell membrane is damaged, so that the antibacterial performance is superior to the conventional polymer antibacterial agent. The solubility parameter is preferably 14 or less, more preferably 13 or less, and still more preferably 12 or less. The solubility parameter is usually 5 or more.

The hydrophobic monomer (B) is not particularly limited as long as the solubility parameter in the homopolymer is 15 or less, but is an ester of (meth) acrylic acid and an optionally substituted alcohol. ((Meth) acrylate optionally having a substituent); Unsaturated monocarboxylic acids such as (meth) acrylic acid, crotonic acid, α-allyloxyacrylic acid and salts thereof; Aromatic vinyl such as styrene Olefin monomers such as propylene; esters of unsaturated alcohols such as vinyl acetate with carboxylic acids; vinyl halides such as vinyl chloride; alkyl vinyl ethers such as methyl vinyl ether and ethyl vinyl ether; 1-allyloxy An unsaturated monomer having a cyclic ether-containing group having 2 to 8 carbon atoms such as -3-butoxypropan-2-ol and 1 to 2 carbon atoms Addition reaction product of alcohol with allyl alcohol; ethylene oxide adduct of allyl alcohol, ethylene oxide adduct of methallyl alcohol, ethylene oxide adduct of isoprenol, etc., and alkylene oxide adducts of unsaturated alcohols having 2 to 20 carbon atoms and terminal hydrophobic modification thereof And cyclic vinyl monomers such as N-vinylpyrrolidone.
Among the hydrophobic monomers having a solubility parameter of 15 or less, those having an alkyl group having 2 or more carbon atoms are preferred. When the hydrophobic monomer has an alkyl group having 2 or more carbon atoms, the affinity with the cell membrane of the microorganism is increased, and the antibacterial property is further improved.

Examples of the salt of the unsaturated monocarboxylic acid include metal salts. Examples of the metal of the metal salt include alkali metals such as lithium, sodium, and potassium.

Examples of the substituent in the (meth) acrylate include a hydroxyl group; an alkoxy group having 1 to 18 carbon atoms such as a methoxy group and an ethoxy group; an oxo group-containing group such as an oxyalkylene group, a sulfonic acid group, and a phosphoric acid group; A halogeno group, an epoxy group such as a glycidyl group, a carbonyl group such as an aldehyde group, and the like.

Although it does not restrict | limit especially as (meth) acrylate which may have the above substituents, The following general formula (10);

(Wherein R ⁹ represents a hydrogen atom or a methyl group. R ¹⁰ represents a hydrocarbon group which may have a substituent).
The hydrocarbon group which may have a substituent refers to a group in which one or two or more hydrogen atoms of a hydrocarbon group are substituted with a group other than a hydrocarbon group. When it is a hydrocarbon group having a substituent and the substituent has a (poly) oxyalkylene group, the hydrocarbon group preferably has 3 to 200 carbon atoms. When at least the substituent does not have a (poly) oxyalkylene group, the hydrocarbon group which may have a substituent preferably has 1 to 30 carbon atoms. When the hydrocarbon group which may have the above substituent has a substituent, the number of carbons contained in the substituent is also included in the above carbon number.

The hydrocarbon group is not particularly limited, and examples thereof include chain hydrocarbon groups such as alkyl groups, alkenyl groups, and alkynyl groups, and cyclic hydrocarbon groups such as aromatic hydrocarbon groups, cycloalkyl groups, and cycloalkenyl groups. .
Examples of the alkyl group include methyl group, ethyl group, propyl group, isopropyl group, n-butyl group, isobutyl group, sec-butyl group, tert-butyl group, pentyl group, isopentyl group, neopentyl group, hexyl group, Heptyl, octyl, 2-ethylhexyl, isooctyl, nonyl, 2,3,5-trimethylhexyl, decyl, undecyl, 4-ethyl-5-methyloctyl, dodecyl, tridecyl, tetradecyl And linear or branched alkyl groups such as a group, pentadecyl group, hexadecyl group, heptadecyl group, and octadecyl group.
Examples of the alkenyl group include vinyl group, allyl group, 1-butenyl group, 2-butenyl group, pentenyl group, hexenyl group, heptenyl group, octenyl group, nonenyl group, decenyl group, dodecenyl group, octadecenyl group, icocenyl group. Etc.
Examples of the alkynyl group include ethynyl group, 1-propynyl group, 2-propynyl group, butynyl group, pentynyl group, hexynyl group, heptynyl group, octynyl group, nonynyl group, decynyl group, dodecynyl group, octadecynyl group, icosinyl group. Etc.

Examples of the aromatic hydrocarbon group include a phenyl group, a benzyl group, a tolyl group, an o-xylyl group, and the like.
Examples of the cycloalkyl group include a cyclopropyl group, a cyclobutyl group, a cyclopentyl group, a cyclohexyl group, and the like.
Examples of the cycloalkenyl group include a cyclopropenyl group, a cyclobutenyl group, a cyclopentenyl group, and a cyclohexenyl group.

Examples of the alkyl (meth) acrylate having no substituent as described above include methyl (meth) acrylate, ethyl (meth) acrylate, n-propyl (meth) acrylate, isopropyl (meth) acrylate, and n-butyl (meth) ) Acrylate, isobutyl (meth) acrylate, tert-butyl (meth) acrylate, sec-butyl (meth) acrylate, 2-ethylhexyl (meth) acrylate, n-octyl (meth) acrylate, tridecyl (meth) acrylate, cyclohexyl (meth) ) Cycloalkyl (meth) acrylate such as acrylate, n-lauryl (meth) acrylate, dodecyl (meth) acrylate, stearyl (meth) acrylate, isobornyl methacrylate and the like.

Examples of the hydroxyl group-containing (meth) acrylate include 2-hydroxyethyl (meth) acrylate, 2-hydroxypropyl (meth) acrylate, 3-hydroxypropyl (meth) acrylate, 2-hydroxybutyl (meth) acrylate, and 4-hydroxy Examples thereof include a hydroxyl group-containing (meth) acrylate having 1 to 18 carbon atoms in an ester group such as butyl (meth) acrylate.

Examples of the alkoxy group-containing (meth) acrylate include methoxyethyl (meth) acrylate, methoxypropyl (meth) acrylate, methoxybutyl (meth) acrylate, ethoxybutyl (meth) acrylate, trimethylolpropane tripropoxy (meth) acrylate, and the like. Is mentioned.

Examples of the oxo group-containing (meth) acrylate include sulfopropyl (meth) acrylate; (meth) acryloyloxyethyl phosphate.

Examples of the fluoro group-containing (meth) acrylate include fluoro groups having 2 to 6 carbon atoms in an ester group such as trifluoroethyl (meth) acrylate, tetrafluoropropyl (meth) acrylate, and octafluoropentyl (meth) acrylate. Examples include alkyl (meth) acrylate.

Examples of the epoxy group-containing (meth) acrylate include glycidyl (meth) acrylate and α-methylglycidyl (meth) acrylate.

Examples of the carbonyl group-containing (meth) acrylate include acetonyl (meth) acrylate, diacetone (meth) acrylate, 2-hydroxypropyl (meth) acrylate acetyl acetate, butanediol-1,4-acrylate acetyl acetate, and 2- (acetoate). Acetoxy) ethyl (meth) acrylate, (meth) acryloyloxyalkylpropenal, and the like.

The hydrophobic monomer (B) preferably contains at least one (meth) acrylic acid ester.
As the (meth) acrylic acid ester, a compound represented by the above formula (10), that the carbon number of the hydrocarbon group R ¹⁰ of formula (10) is compound 1-20 preferable.
Carbon number of the hydrocarbon group of R ^{10 in} the above formula (10) is more preferably 1 to 16, further preferably 1 to 12, particularly preferably 1 to 8, and most preferably 2 to 8. It is.
When the hydrocarbon group has 1 to 20 carbon atoms, the water solubility and viscosity of the polymer can be adjusted to suitable ranges, and the handling is excellent. When the hydrocarbon group has 1 to 12 carbon atoms, the production of the polymer is facilitated, and in addition to antibacterial properties, it is excellent in safety. Further, when the hydrocarbon group has 2 to 8 carbon atoms, not only the polymer can be easily produced, but also the safety is excellent, the affinity with the cell membrane of the microorganism is increased, and the antibacterial property is further improved. It will be a thing.
The hydrocarbon group is preferably an alkyl group or an alkenyl group, and more preferably an alkyl group.
That is, the (meth) acrylic acid ester is preferably a (meth) acrylic acid alkyl ester (alkyl (meth) acrylate), and the hydrophobic monomer (B) is composed of at least one (meth) acrylic acid alkyl ester. It is preferable to include.

The alkyl (meth) acrylate is preferably methyl (meth) acrylate, ethyl (meth) acrylate, n-propyl (meth) acrylate, isopropyl (meth) acrylate, n-butyl (meth) acrylate, isobutyl (meth) acrylate, tert- Butyl (meth) acrylate, sec-butyl (meth) acrylate, 2-ethylhexyl (meth) acrylate, n-octyl (meth) acrylate, more preferably methyl (meth) acrylate, ethyl (meth) acrylate, n- Propyl (meth) acrylate, isopropyl (meth) acrylate, n-butyl (meth) acrylate, isobutyl (meth) acrylate, tert-butyl (meth) acrylate, sec-butyl (meth) acrylate, 2 It is ethylhexyl (meth) acrylate.

The copolymer contained in the antiseptic antibacterial agent of the present invention is also a hydrophobic monomer (B) having a structural unit derived from (meth) acrylic acid alkyl ester, and further having a solubility parameter of 15 or less, And a structural unit derived from a monomer having at least one functional group selected from the group consisting of a group, a hydroxyl group and an ether group. A copolymer having such a structural unit is also one preferred embodiment of the present invention.
The monomer having at least one functional group selected from the group consisting of the carboxyl group, the hydroxyl group and the ether group has a solubility parameter of 15 or less, and has any functional group of the carboxyl group, the hydroxyl group and the ether group. What is necessary is just to have, Even if it has a (meth) acrylic acid ester structure, it has at least 1 sort (s) of functional group selected from the group which consists of a carboxyl group, a hydroxyl group, and an ether group It shall be classified as a monomer.
In the present invention, as the hydrophobic monomer (B), the above (meth) acrylic acid alkyl ester is copolymerized with a monomer having at least one functional group selected from the group consisting of a carboxyl group, a hydroxyl group and an ether group. In this way, the water solubility of the resulting copolymer is improved, and the effects of precipitation of the copolymer due to salt and pH, reduction in antibacterial properties, etc. can be alleviated more sufficiently, so in a wide pH range. A copolymer can be used, and it can be suitably used for cosmetic applications that are often weakly acidic.
Examples of the monomer having at least one functional group selected from the group consisting of the carboxyl group, the hydroxyl group, and the ether group include the above-described unsaturated monocarboxylic acids; hydroxyl group-containing (meth) acrylates; alkyl vinyl ethers; An alkylene oxide adduct of 20 unsaturated alcohols; an addition reaction product of an unsaturated monomer having a cyclic ether-containing group having 2 to 8 carbon atoms and an alcohol having 1 to 20 carbon atoms, and the like.

Examples of the monomer having at least one functional group selected from the group consisting of a carboxyl group, a hydroxyl group and an ether group include unsaturated monocarboxylic acids; hydroxyl group-containing (meth) acrylates; alkylene having 2 to 20 carbon atoms. Oxide adduct: An addition reaction product of an unsaturated monomer having a cyclic ether-containing group having 2 to 8 carbon atoms and an alcohol having 1 to 20 carbon atoms is preferable.
As the unsaturated monocarboxylic acids, (meth) acrylic acid and salts thereof are preferable.
As the hydroxyl group-containing (meth) acrylate, 2-hydroxyethyl (meth) acrylate is preferable.

The number of carbon atoms of the unsaturated alcohol having 2 to 20 carbon atoms is preferably 2 to 18, and examples of the unsaturated alcohol having 2 to 20 carbon atoms include vinyl alcohol, allyl alcohol, and isoprenyl alcohol (isoprenol). Can be mentioned.
The carbon number of alkylene oxide in the alkylene oxide adduct of unsaturated alcohol having 2 to 20 carbon atoms is preferably 2 to 20, more preferably 2 to 8, and further preferably 2 to 6. Particularly preferably, it is 2 to 4, and most preferably 2 to 3. Examples of the alkylene oxide include ethylene oxide, propylene oxide, butylene oxide, isobutylene oxide, 1-butene oxide, 2-butene oxide, and styrene oxide. More preferred are ethylene oxide, propylene oxide and butylene oxide, and still more preferred are ethylene oxide and propylene oxide.
It is preferable that the average added mole number of the said alkylene oxide is 1-100. More preferably, it is 1-80, More preferably, it is 1-70, Most preferably, it is 1-50.
As the alkylene oxide adduct of unsaturated alcohol having 2 to 20 carbon atoms, an ethylene oxide adduct of isoprenol is preferable.

Examples of the alcohol having 1 to 20 carbon atoms include alkyl alcohols such as methanol, ethanol, propanol, butanol, pentanol, and hexanol. Preferred are alkyl alcohols having 2 to 16 carbon atoms such as ethanol, propanol and butanol.
As the addition reaction product of the unsaturated monomer having a cyclic ether-containing group having 2 to 8 carbon atoms and an alcohol having 1 to 20 carbon atoms, 1-allyloxy-3-butoxypropan-2-ol is preferable.

The copolymer of the present invention may have a structural unit derived from another monomer other than the amino group-containing monomer (A) and the hydrophobic monomer (B). Other monomers are not particularly limited as long as they have no amino group and can be copolymerized with an amino group-containing monomer and a hydrophobic monomer. The solubility parameter of other monomer homopolymers may be 15 or less, or may exceed 15. Even if the solubility parameter of the other monomer is 15 or less or more than 15, as long as the hydrophobic monomer is polymerized at a preferred ratio, the hydrophobicity as a copolymer is It will be fully maintained.
Moreover, the monomer which has 2 or more of ethylenically unsaturated groups may be contained irrespective of the value of a solubility parameter from a viewpoint of adjusting a viscosity. Monomers having two or more ethylenically unsaturated groups include ethylene glycol, propylene glycol, polyoxyethylene glycol, polyoxypropylene glycol, glycerin, polyglycerin, trimethylolpropane, pentaerythritol, saccharose, sorbitol, 1, Esters of (meth) acrylic acid with two or more hydroxyl groups of a polyol such as 4-butanediol; Dimethacrylic acid esters with two or more substitutions of the polyol; Dihydroxy group with two or more substitutions of the polyol and allyl alcohol, vinyl alcohol Ethers with unsaturated alcohols such as diallyl phthalate, triallyl phosphate, allyl methacrylate, tetraallyloxyethane, triallyl cyanurate, divinyl adipate, vinyl crotonate, 1,5-hexadi Emissions, divinylbenzene and the like. These other monomers may be used alone or in combination of two or more.
From the viewpoint of improving antibacterial properties, the present invention may be copolymerized with a polymerizable metal salt as another monomer. Examples of the polymerizable metal salt include heavy metal salts of unsaturated carboxylic acids such as zinc acrylate, zinc methacrylate, and α-allyloxyzinc acrylate.

In the copolymer of the present invention, the proportion of the structural unit derived from the hydrophobic monomer (B) in the copolymer is such that the structural unit (a) 100 derived from the amino group-containing monomer (A) in the copolymer. It is preferable that it is 0.1-99.9 mass% with respect to the mass%. More preferably, it is 0.5-90 mass%, More preferably, it is 1-80 mass%, More preferably, it is 2-70 mass%, More preferably, it is 3-64 mass%, More preferably, it is 4 It is -60 mass%, Especially preferably, it is 5-50 mass%, Most preferably, it is 5-40 mass%, Most preferably, it is 5-30 mass%. If the content ratio of the structural unit derived from the hydrophobic monomer (B) in the copolymer of the present invention is in such a range, the antibacterial performance of the copolymer is improved, and in particular, Escherichia coli having an outer membrane or It tends to exhibit high antibacterial performance against gram-negative bacteria such as Pseudomonas aeruginosa.

As described above, the copolymer of the present invention has at least a hydrophobic monomer (B) selected from the group consisting of a structural unit derived from an alkyl (meth) acrylate and a carboxyl group, a hydroxyl group and an ether group. A structural unit derived from a monomer having one type of functional group, and derived from a monomer having at least one type of functional group selected from the group consisting of a carboxyl group, a hydroxyl group and an ether group in the copolymer. The proportion of the structural unit is preferably 0 to 100% by mass with respect to 100% by mass of the structural unit derived from the (meth) acrylic acid alkyl ester. More preferably, it is 0-50 mass%.

In the copolymer of the present invention, the structural unit (a) derived from the amino group-containing monomer (A) is 0.01 to 99.9 mass% with respect to 100 mass% of the total amount of the structural units forming the copolymer. % Is preferable. More preferably, it is 0.1-99 mass%, More preferably, it is 1-98 mass%, More preferably, it is 10-97 mass%, More preferably, it is 30-96 mass%, More preferably, it is 36 It is -96 mass%, Most preferably, it is 50-95 mass%, Most preferably, it is 60-95 mass%, Most preferably, it is 70-95 mass%.
In the copolymer of the present invention, the proportion of the structural unit (b) derived from the hydrophobic monomer (B) is 0.01 to 90% by mass with respect to 100% by mass of the total amount of the structural units forming the copolymer. It is preferable to have. More preferably, it is 0.05-80 mass%, More preferably, it is 0.1-70 mass%, More preferably, it is 0.2-64 mass%, More preferably, it is 0.5-60 mass% Still more preferably, it is 1-50 mass%, Most preferably, it is 3-50 mass%, Most preferably, it is 4-40 mass%, Most preferably, it is 5-30 mass%.

When the structural unit derived from the (meth) acrylic acid alkyl ester is used as the structural unit derived from the hydrophobic monomer (B) of the copolymer of the present invention, the total amount of structural units forming the copolymer is 100% by mass. The proportion of the structural unit derived from the (meth) acrylic acid alkyl ester is preferably 0.01 to 60% by mass. More preferably, it is 1-50 mass%, More preferably, it is 3-40 mass%.

In the antiseptic antibacterial agent of the present invention, the content of the structural unit (e) derived from the other monomer (E) is 0 to 10% by mass with respect to 100% by mass of the total amount of the structural units forming the copolymer. It is preferable that More preferably, it is 0-8 mass%, More preferably, it is 0-5 mass%. Among other monomers, the content ratio of the structural unit derived from the monomer having two or more ethylenically unsaturated groups is 0 to 1% by mass with respect to 100% by mass of the total amount of the structural units forming the copolymer. More preferably, it is 0-0.5 mass%, More preferably, it is 0-0.1 mass%.

The copolymer contained in the antiseptic antibacterial agent of the present invention comprises only the structural unit (a) derived from the amino group-containing monomer (A) and the structural unit (b) derived from the hydrophobic monomer (B). Copolymers are also one preferred form. In this case, the sum of the proportions of the structural units (a) and (b) is 100% by mass, and the proportion of the structural units (a) or (b) is from 100% by mass to the structural unit (b) or ( A value obtained by subtracting the ratio of a).

The weight average molecular weight of the copolymer contained in the antiseptic antibacterial agent for cosmetics of the present invention is 4,000 to 1,000,000. If the weight average molecular weight of the copolymer is in such a range, the antiseptic antibacterial agent adsorptivity to the material using the antiseptic antibacterial agent is improved, so that it is sufficiently suppressed from being washed away when washed, Antibacterial effect on the material is improved.
The weight average molecular weight is preferably 4,000 to 800,000, more preferably 5,000 to 600,000, still more preferably 6,000 to 400,000, still more preferably 7,000 to 200,000, still more preferably 7,000. 100,000, particularly preferably 7000 to 80,000. The weight average molecular weight of a copolymer can be measured by the method as described in an Example.

Examples of the structure of the copolymer contained in the antiseptic antibacterial agent for cosmetics of the present invention include a random copolymer structure, a graft structure, a block copolymer structure, a gradient copolymer structure, a star structure, a dendrimer structure, Any structure may be sufficient.

<Method for producing copolymer>
Although the production of the copolymer of the present invention is not particularly limited, it can be produced by polymerizing the monomer component, and specific examples and preferred examples of the monomer component are as described above. Moreover, the preferable content rate of the monomers (A), (B), and (E) in the monomer component is the preferable ratio of the structural units (a), (b), and (e) in the above-mentioned copolymer. It is the same.

The copolymer is preferably produced by a method in which the monomer component is polymerized in the presence of a polymerization initiator. When the monomer component is polymerized, a polymerization initiator can be appropriately used depending on the polymerization method. As the polymerization initiator, those usually used can be used, for example, hydrogen peroxide; persulfates such as sodium persulfate and ammonium persulfate; dimethyl 2,2′-azobis (2-methylpropionate). ), 2,2′-azobis (isobutyronitrile), 2,2′-azobis (2-methylbutyronitrile), 2,2′-azobis (isobutyric acid) dimethyl, 4,4′-azobis (4 -Cyanovaleric acid), 2,2'-azobis (2-methylpropionamidine) dihydrochloride, 2,2'-azobis [N- (2-carboxyethyl) -2-methylpropionamidine] n hydrate, 2,2′-azobis [2- (2-imidazolin-2-yl) propane] dihydrochloride, 2,2′-azobis [2- (2-imidazolin-2-yl) propane] disulfate dihydrate object, , 1′-azobis (cyclohexane-1-carbonitrile), 2,2′-azobis [N- (2-propenyl) -2-methylpropionamide], etc .; benzoyl peroxide, lauroyl peroxide, peroxy Organic peroxides such as acetic acid and di-t-butyl peroxide are preferred. Of these polymerization initiators, azo compounds are preferred. The polymerization initiator is not limited to such examples. These polymerization initiators may be used alone or in combination of two or more.

The amount of the polymerization initiator used is not particularly limited as long as it can start polymerization of the monomer component, but is usually 0.01 to 50 parts by mass with respect to 100 parts by mass of all monomer components. , Preferably it is 0.05-30 mass parts, More preferably, it is 0.05-20 mass parts.

The amino group-containing monomer used in the present invention may be used as an acid neutralized product neutralized with an acid or a quaternary ammonium salt quaternized with a quaternizing agent. By using quaternized amino group-containing monomers, higher antibacterial performance is exhibited against Gram-positive bacteria such as Staphylococcus aureus.
Acids used for neutralization of amino group-containing monomers are not particularly limited, but include inorganic acids such as hydrochloric acid and sulfuric acid; acetic acid, citric acid, tartaric acid, toluenesulfonic acid, lactic acid, succinic acid, glycolic acid Organic acids such as
The quaternizing agent for the amino group-containing monomer is as described above.

When the acid or quaternizing agent is used, the amount used thereof is not particularly limited as long as part or all of the amino group-containing monomer is neutralized or quaternized. It is preferable that an acid or a quaternizing agent is 0.1-1 mol with respect to 1 mol of an amino group-containing monomer to be used.

In the above copolymerization method, monomer components, polymerization initiators, etc. can be added to the reaction vessel by charging all of the monomer components into the reaction vessel and adding the polymerization initiator into the reaction vessel. Method of performing polymerization: charging a part of the monomer component into the reaction vessel, and adding the polymerization initiator and the remaining monomer component continuously or stepwise (preferably continuously) into the reaction vessel. A method in which a polymerization solvent is charged into a reaction vessel and the whole amount of monomer components and a polymerization initiator is added; a part of one of the monomers (for example, an amino group-containing monomer) Is preferably carried out by adding a polymerization initiator and the remaining monomer component into the reaction vessel (preferably continuously). Among these methods, since the molecular weight distribution of the obtained copolymer can be narrowed (sharpened), it is possible to carry out copolymerization by a method in which a polymerization initiator and a monomer component are successively dropped into a reaction vessel. preferable.

Examples of the copolymerization method include solution polymerization, bulk polymerization, suspension polymerization, emulsion polymerization, living polymerization, and graft polymerization, and are not particularly limited, but solution polymerization is preferable. The solvent that can be used in this case is preferably water. When only water is used, it is preferable in that the solvent removal step can be omitted.

The copolymerization method can be carried out either batchwise or continuously. In addition, a known solvent can be used as necessary in the copolymerization, and water; monohydric alcohols such as methyl alcohol, ethyl alcohol, isopropyl alcohol, butanol, and THF (tetrahydrofuran); Polyhydric alcohols such as glycerin, (poly) ethylene glycol, propylene glycol, 1,3-butylene glycol, dipropylene glycol; aromatic or aliphatic hydrocarbons such as benzene, toluene, xylene, cyclohexane, n-heptane; acetic acid Suitable are esters such as ethyl; ketones such as acetone and methyl ethyl ketone; amides such as dimethylformamide; ethers such as diethyl ether and dioxane. These may be used alone or in combination of two or more. Among these, from the viewpoint of the solubility of the monomer component and the resulting copolymer, one or more solvents selected from the group consisting of water and lower alcohols having 1 to 4 carbon atoms may be used. preferable. The solvent is relatively inexpensive, and the production method of the present invention is economically excellent. Moreover, in the said copolymerization method, you may superpose | polymerize by adding polyhydric alcohol solvents, such as propylene glycol and ethylene glycol, to water. When the polyhydric alcohol solvent is used in combination with water, the solubility of the polymer can be increased, and soap-free polymerization can be more sufficiently suppressed. Thereby, the production | generation of a polymer with poor water solubility can fully be suppressed, and the transparency of a solution can be improved more.
When using the said polyhydric alcohol solvent and water together, it is preferable that the ratio of the polyhydric alcohol solvent with respect to 100 mass% of water is 0-200 mass%.
In the method for producing the copolymer of the present invention, any chain transfer agent, pH adjuster, buffering agent, and the like can be used as necessary.

Although the temperature in the case of superposition | polymerization is not specifically limited, Usually, it is 50-120 degreeC, Preferably it is 60-110 degreeC. If the temperature at the time of polymerization is in the above range, the residual monomer component tends to decrease. The temperature at the time of polymerization need not always be kept constant during the progress of the polymerization reaction. For example, the polymerization is started from room temperature, and the temperature is increased to a set temperature at an appropriate temperature increase time or temperature increase rate. Thereafter, the set temperature may be maintained, or the polymerization temperature may be varied (increased or decreased) over time during the course of the polymerization reaction, depending on the dropping method of the monomer component, initiator, and the like. Also good. Further, when the monomer component is polymerized, it is preferable to appropriately stir the monomer component so that the monomer component is uniformly polymerized.

The polymerization time is not particularly limited and may be appropriately set according to the progress of the polymerization reaction, but is usually about 2 to 9 hours.
In the present invention, “polymerization time” refers to the time during which heating and stirring is performed before dropping the monomer, the time during which the monomer is added, and the aging time after the dropping of the monomer.

The pressure in the reaction system may be normal pressure (atmospheric pressure), reduced pressure, or increased pressure. The atmosphere in the reaction system may be either an air atmosphere or an inert atmosphere.

20 mass% or more is preferable and, as for the solid content concentration (namely, polymerization solid content concentration of a monomer) at the time of the completion | finish of the polymerization reaction in the said polymerization reaction system, it is more preferable that it is 25-80 mass%. . Thus, if the solid content concentration at the end of the polymerization reaction is as high as 20% by mass or more, the polymerization can be carried out at a high concentration and in one stage. Therefore, an antiseptic antibacterial agent containing a copolymer can be obtained efficiently, for example, the concentration step that is necessary in some cases in the conventional production method can be omitted. Therefore, the production efficiency can be greatly increased. As a result, the productivity of the antiseptic antibacterial agent of the present invention can be greatly improved, and an increase in production cost can be suppressed.

The method for producing a copolymer of the present invention may be provided with an aging step for the purpose of increasing the polymerization rate of the monomer after the addition of all the raw materials used is completed. The aging time is usually 1 to 240 minutes, preferably 1 to 180 minutes, more preferably 1 to 120 minutes. When the aging time is less than 1 minute, the monomer component may remain due to insufficient aging, causing problems such as toxicity and odor caused by the remaining monomer.

Moreover, the temperature of the preferable polymer solution in an aging process is the same range as the said polymerization temperature. Therefore, the temperature here may also be maintained at a constant temperature (preferably the temperature at the time when the dropping is completed), or the temperature may be changed over time during aging.

The antiseptic antibacterial agent of the present invention may contain other components other than the copolymer of the present invention.
The other components are not particularly limited as long as they do not inhibit the antibacterial performance of the antiseptic antibacterial agent, and examples thereof include additives such as alkali adjusters, anionic surfactants, compatibilizers and stabilizers. .
The antiseptic antibacterial agent of the present invention may further contain a metal salt, a metal oxide, a metal hydroxide, or the like from the viewpoint of improving antibacterial properties. The metal in the metal salt, metal oxide, or metal hydroxide is preferably a heavy metal such as copper, zinc, or silver.
The content of the other components is not particularly limited as long as it does not inhibit the antibacterial performance of the antiseptic antibacterial agent, but is preferably 0 to 20% by mass with respect to 100% by mass of the copolymer.

The antiseptic antibacterial agent of the present invention is preferably used for cosmetic applications such as skin cosmetics, external preparations for skin, or hair (hair) cosmetics.
Although it does not restrict | limit especially as said skin cosmetics, For example, basic cosmetics, such as a lotion, cream, milky lotion, a cosmetic liquid; Makeup cosmetics, such as a liquid foundation, foundation milky lotion, teak color, eye shadow, mascara, lipstick; Cosmetics for cleansing such as cleansing creams, facial cleansing foams, liquid facial cleansers; cosmetics such as sunscreen cosmetics (including quasi-drugs); bath cosmetics such as bath preparations. Examples of the external preparation for skin include external medicines such as liniments, lotions and ointments.
Although it does not restrict | limit especially as said hair cosmetics, For example, shampoo, rinse, treatment, wax, spray, gel, mist etc. are mentioned.

The present invention is also a cosmetic comprising the antiseptic antibacterial agent for cosmetics of the present invention.
The content of the antiseptic antibacterial agent in the cosmetic is not particularly limited, but is 5% by mass or less, more preferably 3% by mass or less, and further preferably 1% by mass or less with respect to 100% by mass of the cosmetic.

Further, in the cosmetic and skin external preparation of the present invention, water and additive components generally incorporated in the cosmetic and skin external preparation as necessary, for example, an oily base, a moisturizer, a touch improver, a surface activity Agent, polymer, thickening / gelling agent, solvent, propellant, antioxidant, reducing agent, oxidizing agent, antiseptic / antibacterial agent other than the antiseptic antibacterial agent of the present invention, chelating agent, pH adjuster, acid, Alkali, powders, inorganic salts, UV absorbers, whitening agents, vitamins and their derivatives, anti-inflammatory agents, anti-inflammatory agents, hair growth agents, blood circulation promoters, stimulants, hormones, anti-wrinkle agents, anti-aging Agent, squeezing agent, cooling sensation agent, warming sensation agent, wound healing promoter, stimulus relaxation agent, analgesic agent, cell activator, plant / animal / microbe extract, antipruritic agent, exfoliating / dissolving agent, antiperspirant, cooling Agents, astringents, enzymes, nucleic acids, fragrances, pigments, colorants, dyes, pigments, water, etc. Kill.

Examples of these additive components include cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, aralkyl alcohol, behenyl alcohol, jojoba alcohol, chimyl alcohol, seraalkyl alcohol, batyl. Higher alcohols such as alcohol, hexyldecanol, isostearyl alcohol, 2-octyldodecanol, dimer diol; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylen Acid, 12-hydroxystearic acid, palmitooleic acid, oleic acid, linoleic acid, linolenic acid, erucic acid, docosahexaenoic acid, ethyl Higher fatty acids such as cosapentaenoic acid, isohexadecanoic acid, anteisohenicosanoic acid, long-chain branched fatty acid, dimer acid, and hydrogenated dimer acid, and metals such as aluminum salts, calcium salts, magnesium salts, zinc salts, and potassium salts Soaps and nitrogen-containing derivatives such as amides; liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin, α-olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalene, petrolatum , Solid paraffin, hydrogenated polydecene and other carbides; candelilla wax, carnauba wax, rice wax, wax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, microcrystalline wax Waxes such as cox, petrolatum, Fischer-Tropsch wax, polyethylene wax, ethylene propylene copolymer; palm oil, palm oil, palm kernel oil, safflower oil, olive oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, Wheat germ oil, macadamia nut oil, hazelnut oil, kukui nut oil, rosehip oil, meadow foam oil, persic oil, tea tree oil, mint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil Vegetable oils such as peanut oil, rice bran oil, cacao butter, shea butter, hydrogenated palm oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil; beef tallow, milk fat, horse fat, egg yolk oil, mink oil, turtle Animal fats and oils such as oil; animal nature such as whale wax, lanolin and orange luffy oil C class;

Lanolins such as liquid lanolin, reduced lanolin, adsorptive lanolin, lanolin acetate, lanolin acetate, hydroxy lanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin alcohol acetate, acetic acid (cetyl lanolyl) ester Phospholipids such as lecithin, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingomyelin, etc .; phospholipids such as phosphatidic acid, lysolecithin; hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogen Phospholipid derivatives such as added egg yolk phospholipid, partially hydrogenated egg yolk phospholipid; cholesterol, dihydrocholesterol, lanosterol, dihydrora Sterols such as sterol, phytosterol, cholic acid; sapogenins; saponins; cholesteryl acetate, cholesteryl nonanoate, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, di-N-lauroyl-L-glutamate (cholesteryl / behenyl / octyl) Dodecyl), N-lauroyl-L-glutamate di (cholesteryl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / octyldodecyl), Acyl sarcosine alkyl esters such as N-lauroyl sarcosine isopropyl, cholesteryl 12-hydroxystearate, macadamia nut oil fatty acid cholesteryl, maca Sterol esters such as peanut fatty acid phytosteryl, phytosteryl isostearate, soft lanolin fatty acid cholesteryl, hard lanolin fatty acid cholesteryl, long chain branched fatty acid cholesteryl, long chain α-hydroxy fatty acid cholesteryl; phospholipid / cholesterol complex, phospholipid / phytosterol complex Lipid complexes such as the body;

Octyldodecyl myristate, hexyldecyl myristate, octyldodecyl isostearate, cetyl palmitate, octyldodecyl palmitate, cetyl octanoate, hexyl decyl octanoate, isotridecyl isononanoate, isononyl isononanoate, octyl isononanoate Isodecyl acid, isotridecyl neopentanoate, isostearyl neopentanoate, octyldodecyl neodecanoate, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, octyldodecyl lanthanate fatty acid, octyldodecyl dimethyloctanoate, octyldodecyl erucate, isostearic acid curing Castor oil, ethyl oleate, avocado oil fatty acid ethyl, myristic acid isop Pill, isopropyl palmitate, octyl palmitate, isopropyl isostearate, lanolin fatty acid isopropyl, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, diisopropyl adipate, dibutyloctyl sebacate, diisobutyl adipate, dioctyl succinate, triethyl citrate Monoalcohol carboxylic esters such as cetyl lactate, diisostearyl malate, monoisostearic acid hydrogenated castor oil, and the like;

Triethylhexanoin, glyceryl trioctanoate, glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, glyceryl tri (caprylic acid / capric acid), tri (caprylic acid / capric acid / myristic acid / stearic acid) glyceryl, hydrogenated Rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), glyceryl behenate, trimethylolpropane trioctanoate, trimethylolpropane triisostearate, neopentyl glycol dioctanoate, neopentyl glycol dicaprate, dioctanoic acid 2-butyl-2-ethyl-1,3-propanediol, propylene glycol dioleate, pentaerythrityl tetraoctanoate, hydrogenated Ginpentaerythrityl, triethylhexanoic acid ditrimethylolpropane, (isostearic acid / sebacic acid) ditrimethylolpropane, triethylhexanoic acid pentaerythrityl, (hydroxystearic acid / stearic acid / rosinic acid) dipentaerythrityl, diisostearate diglyceryl, tetraisostearin Polyglyceryl acid, polyglyceryl nonaisostearate-10, deca (erucic acid / isostearic acid / ricinoleic acid) polyglyceryl-8, (hexyldecanoic acid / sebacic acid) diglyceryl oligoester, glycol distearate (ethylene glycol distearate), etc. Alcohol fatty acid esters;

Dimer dilinoleate diisopropyl, dimer dilinoleate diisostearyl, dimer dilinoleate di (isostearyl / phytosteryl), dimer dilinoleate (phytosteryl / behenyl), dimer dilinoleate (phytosteryl / isostearyl / cetyl / stearyl / Dimer acids or dimers such as behenyl), dimer dilinoleic acid dimer dilinoleyl, diisostearic dimer dilinoleyl, dimer dilinoleic hydrogenated rosin condensate, dimer dilinoleic acid hydrogenated castor oil, hydroxyalkyl dimer dilinoleyl ether Derivatives of diol: coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA) , Lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (partamide MEA), palmitic acid diethanolamide (partamide DEA), coconut oil fatty acid methylethanolamide (cocamide methyl MEA), etc. Fatty acid alkanolamides: dimethicone (dimethylpolysiloxane), highly polymerized dimethicone (highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclopentasiloxane), phenyltrimethicone, diphenyldimethicone, phenyldimethicone, stearoxy Propyldimethylamine, (aminoethylaminopropylmethicone / dimethicone) copolymer, dimethiconol, dimethiconol Ross polymer, silicone resin, silicone rubber, amino-modified silicone such as aminopropyl dimethicone and amodimethicone, polyether-modified silicone such as cation-modified silicone and dimethicone copolyol, polyglycerin-modified silicone, sugar-modified silicone, carboxylic acid-modified silicone, phosphorus Acid-modified silicone, sulfuric acid-modified silicone, alkyl-modified silicone, fatty acid-modified silicone, alkyl ether-modified silicone, amino acid-modified silicone, peptide-modified silicone, fluorine-modified silicone, cation-modified and polyether-modified silicone, amino-modified and polyether-modified silicone, alkyl Silicones such as modified and polyether-modified silicones and polysiloxane / oxyalkylene copolymers; perfluorodecane, Fluorine-based oils such as -fluorooctane and perfluoropolyether are preferred.

As the humectant / feel improver, glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, Polyols such as trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, ethylene glycol / propylene glycol copolymer and polymers thereof; diethylene glycol monoethyl ether (Ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol dibutyl ether, etc. Sugars such as sorbitol, xylitol, erythritol, mannitol, maltitol; glucose, fructose, galactose, mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, lactose, raffinose, gluconic acid , Glucuronic acid, cyclodextrins (α-, β-, γ-cyclodextrin and modified cyclodextrins such as maltosylation, hydroxyalkylation, etc.), β-glucan, chitin, chitosan, heparin and derivatives, pectin, arabino Sugars and derivatives thereof such as galactan, dextrin, dextran, glycogen, ethyl glucoside, glucosyl ethyl methacrylate polymer or copolymer; hyaluronic acid, hyal Sodium ronate; sodium chondroitin sulfate; mucoitin sulfate, caroline sulfate, keratosulfate, dermatan sulfate; white jellyfish extract, white jellyfish polysaccharide; fucoidan; tuberose polysaccharide, naturally-occurring polysaccharide; organic acids such as citric acid, tartaric acid, lactic acid and the like Its salts; urea; 2-pyrrolidone-5-carboxylic acid and its salts such as sodium;

Betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, Amino acids such as valine, tryptophan, histidine, taurine and salts thereof; collagen, collagen derived from fish, atelocollagen, gelatin, elastin, collagen degrading peptide, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin degrading peptide, keratin degrading peptide Hydrolyzed keratin, conchiolin degrading peptide, hydrolyzed conchiolin, silk proteolytic peptide, hydrolyzed silk Lauroyl hydrolyzed silk sodium, soybean proteolytic peptide, wheat proteolytic peptide, hydrolyzed wheat protein, casein degrading peptide, acylated peptide and other protein peptides and derivatives thereof; palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide, etc. Acylated peptides; silylated peptides; lactic acid bacteria culture solution, yeast extract, eggshell membrane protein, bovine submandibular mucin, hypotaurine, sesameignan glycoside, glutathione, albumin, whey; choline chloride, phosphorylcholine; placental extract , Aerlastin, collagen, aloe extract, hamamelis water, loofah water, chamomile extract, licorice extract, comfrey extract, silk extract, Izayoi rose extract, yarrow extract, eucalyptus extract, merirotoe Preferred are ceramides such as animal / plant extract components such as kisses, natural ceramides (types 1, 2, 3, 4, 5, 6), hydroxyceramides, pseudoceramides, glycosphingolipids, ceramides and sugar-ceramide-containing extracts As mentioned.

Preferred examples of the surfactant include an anionic surfactant, a nonionic surfactant, a cationic surfactant, an amphoteric surfactant, and a polymer surfactant. There is no restriction | limiting in particular in HLB of surfactant, It can use from about 1 low thing to about 20 high thing, It is also preferable to combine a low thing and a high thing of HLB.
Examples of preferable surfactants include fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfates such as sodium lauryl sulfate, triethanolamine lauryl sulfate, and ammonium lauryl sulfate; laureth Polyoxyethylene alkyl sulfates such as sodium sulfate and laureth sulfate triethanolamine; cocoyl methyl taurine sodium, cocoyl methyl taurine potassium, lauroyl methyl taurine sodium, myristoyl methyl taurine sodium, lauroyl methyl alanine sodium, lauroyl sarcosine sodium, lauroyl sarcosine triethanol Acyl N-methyl amino acid salts such as amines and sodium methylalanine lauroylglutamate; Cocoyl Glue Acyl amino acid salts such as sodium minate, triethanolamine cocoyl glutamate, sodium lauroyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, ditriethanolamine palmitoyl aspartate, cocoylalanine triethanolamine; polyoxyethylene alkyl ethers such as sodium laureth acetate Acetic acid salt; Succinic acid ester salt such as sodium lauroyl monoethanolamide succinate; Fatty acid alkanolamide ether carboxylate; Acyl lactate; Polyoxyethylene fatty amine sulfate; Fatty acid alkanolamide sulfate; Hardened coconut oil fatty acid sodium glyceryl sulfate Fatty acid glyceride sulfate such as alkylbenzene polyoxyethylene sulfate; α-olefin Olefin sulfonates such as sodium sulfonate; alkylsulfosuccinates such as disodium lauryl sulfosuccinate and dioctyl sodium sulfosuccinate; disodium laureth sulfosuccinate, monolauroyl monoethanolamide polyoxyethylene sodium sulfosuccinate, lauryl polypropylene glycol sulfosuccinic acid Alkyl ether sulfosuccinates such as sodium; alkylbenzene sulfonates such as sodium tetradecylbenzenesulfonate and tetraethanolamine tetraethanol; alkylnaphthalenesulfonates; alkanesulfonates; α-sulfo fatty acid methyl ester salts; Acyl isethionate; alkyl glycidyl ether sulfonate; alkyl sulfoacetate; laurethrin Alkyl ether phosphates such as sodium, sodium dilaureth phosphate, sodium trilaureth phosphate, sodium monooles phosphate; alkyl phosphate salts such as potassium lauryl phosphate; sodium caseinate; alkyl aryl ether phosphate; fatty acid amide ether phosphorus Acid salts; phospholipids such as phosphatidylglycerol, phosphatidylinositol, and phosphatidic acid; silicone-based anionic surfactants such as carboxylic acid-modified silicone, phosphate-modified silicone, and sulfate-modified silicone;

Nonionic surfactants include laureth (polyoxyethylene lauryl ether), ceteth (polyoxyethylene cetyl ether), steareth (polyoxyethylene stearyl ether), behenes (polyoxyethylene behenyl ether), isosteares (poly Polyoxyethylene alkyl ethers with various polyoxyethylene addition numbers such as oxyethylene isostearyl ether), octyldecesses (polyoxyethylene octyldodecyl ether); polyoxyethylene alkylphenyl ether; polyoxyethylene hydrogenated castor oil, poly Oxyethylene castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil mono Polyglutamic acid monoisostearic acid diester, castor oil and hardened castor oil derivatives such as polyoxyethylene hydrogenated castor oil maleic acid; polyoxyethylene phytosterol; polyoxyethylene cholesterol; polyoxyethylene cholestanol; polyoxyethylene lanolin; polyoxyethylene lanolin; Lanolin; polyoxyethylene / polyoxypropylene cetyl ether, polyoxyethylene / polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene / polyoxypropylene monobutyl ether, polyoxyethylene / polyoxypropylene hydrogenated lanolin, polyoxyethylene・ Polyoxyethylene such as polyoxypropylene glycerin ether ・ Polyoxypropylene alkyl ether; Polyoxyethylene Polyoxypropylene glycol; (poly) glycerin polyoxypropylene glycol such as PPG-9 diglyceryl; glyceryl stearate, glyceryl isostearate, glyceryl palmitate, glyceryl myristate, glyceryl oleate, glyceryl palm oil fatty acid, mono cottonseed oil fatty acid Glycerin fatty acid partial esters such as glycerin, glyceryl monoerucate, glyceryl sesquioleate, glycerin α, α'-oleic acid pyroglutamate, glyceryl monostearate, malic acid monostearate; polyglyceryl-2 stearate, 3, 4, 4 , 6, 8, 10, polyglyceryl distearate-6, 10, polyglyceryl tristearate, polyglyceryl decastearate-10, polyglyceryl isostearate -2, 3, 4, 5, 6, 8, 10, diglycostyl diisostearate (diglyceryl diisostearate), 3, 10, polyglyceryl-2 triisostearate, tetraisostearic acid Polyglyceryl-2, polyglyceryl-10 decaisostearate, polyglyceryl-2 oleate, 3, 4, 5, 6, 8, 10, dioleate polyglyceryl-6, trioleate polyglyceryl-2, dekaoleic acid Polyglyceryl fatty acid esters such as polyglyceryl-10; ethylene glycol monofatty acid esters such as ethylene glycol monostearate; propylene glycol monofatty acid esters such as propylene glycol monostearate; pentaerythritol partial fatty acid esters; sorbitol Partial fatty acid ester; maltitol partial fatty acid ester;

Maltitol ether; sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexylate, tetra Sorbitan fatty acid esters such as diglycerol sorbitan-2-ethylhexylate; sugar derivative partial esters such as sucrose fatty acid ester, methyl glucoside fatty acid ester, and undecylenic acid trehalose; alkyl glucoside such as caprylyl glucoside; alkyl polyglycoside; lanolin alcohol; Lanolin; polyoxyethylene distearate, polyethylene glycol diisostearate, polyoxyethylene monooleate Polyoxyethylene fatty acid mono- and diesters such as polyoxyethylene dioleate; polyoxyethylene propylene glycol fatty acid ester; polyoxyethylene glycerin monostearate, polyoxyethylene glycerin monoisostearate, polyoxyethylene glycerin triisostearate Polyoxyethylene glycerin fatty acid ester such as polyoxyethylene monooleate; polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan tetraoleate, etc. Oxyethylene sorbitan fatty acid ester; polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol Polyoxyethylene sorbitol fatty acid esters such as oleate, polyoxyethylene sorbitol pentaoleate, polyoxyethylene sorbitol monostearate; polyoxyethylene methyl glucoside fatty acid ester; polyoxyethylene alkyl ether fatty acid ester; polyoxyethylene sorbitol beeswax Oxyethylene animal and vegetable fats and oils; alkyl glyceryl ethers such as isostearyl glyceryl ether, chimyl alcohol, ceralkyl alcohol, and batyl alcohol; polyhydric alcohol alkyl ether; polyoxyethylene alkylamine; tetrapolyoxyethylene tetrapolyoxypropylene Ethylenediamine condensates; natural surfactants such as saponins and sophorolipids; polyoxyethylene fat Acid amide; coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide) MIPA), fatty acid alkanolamides such as palmitic acid monoethanolamide (partamide MEA), palmitic acid diethanolamide (partamide DEA), coconut oil fatty acid methylethanolamide (cocamidomethyl MEA);

Alkyldimethylamine oxides such as lauramine oxide, cocamine oxide, stearamine oxide, and behenamine oxide; alkylethoxydimethylamine oxide; polyoxyethylene alkyl mercaptan; polyether-modified silicone such as dimethicone copolyol; polysiloxane oxyalkylene Silicone nonionic surfactants such as copolymers, polyglycerin-modified silicones, sugar-modified silicones, etc .; for cationic surfactants, behentrimonium chloride, steartrimonium chloride, cetrimonium chloride, lauryltrimonium chloride Alkyltrimethylammonium chloride such as stearyltrimonium bromide; alkyltrimethylammonium bromide such as stearyltrimonium bromide; distearyldimonium chloride, dico Dialkyldimethylammonium chlorides such as dimonium chloride; fatty acid amidoamines such as stearamidepropyldimethylamine and stearamideethyldiethylamine and salts thereof; alkyl ether amines such as stearoxypropyldimethylamine and salts or quaternary salts thereof; ethyl sulfate long chain Fatty acid amide type quaternary ammonium salts such as branched fatty acid (12-31) aminopropylethyldimethylammonium and ethyl lanolin sulfate fatty acid aminopropylethyldimethylammonium; polyoxyethylene alkylamine and salts or quaternary salts thereof; alkylamine salt; fatty acid Amidoguanidinium salt; alkyl ether amine ammonium salt; alkyltrialkylene glycol ammonium salt; benzalkonium salt; benzethonium salt; Pyridinium salts such as dinium; imidazolinium salts; alkylisoquinolinium salts; dialkyl morpholinium salts; polyamine fatty acid derivatives; amino-modified silicones such as aminopropyl dimethicone and amodimethicone, cation-modified silicones, cation-modified and polyether-modified Silicone-based cationic surfactants such as silicone, amino-modified and polyether-modified silicones; in amphoteric surfactants, N-alkyl-N, N-dimethylamino acid betaines such as laurylbetaine (lauryldimethylaminoacetic acid betaine); Fatty acid amide alkyl-N, N-dimethylamino acid betaines such as cocamidopropyl betaine and lauramidopropyl betaine; imidazoline type betaines such as sodium cocoamphoacetate and sodium lauroamphoacetate; Alkylsulfobetaines such as rudimethyltaurine; sulfate-type betaines such as alkyldimethylaminoethanol sulfate; phosphate-type betaines such as alkyldimethylaminoethanol phosphate; sphingolines such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin Lipids such as lipid, lysolecithin, hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phospholipid, hydroxylated lecithin; silicone-based amphoteric surfactant, etc .; polymer interface Preferred examples of the activator include polyvinyl alcohol, sodium alginate, starch derivative, tragacanth gum, acrylic acid / alkyl methacrylate copolymer, and various silicone surfactants.

Polymers, thickeners and gelling agents include guar gum, locust bean gum, queens seed, carrageenan, galactan, arabic gum, tara gum, tamarind, far selelain, karaya gum, troarooi, cara gum, tragacanth gum, pectin, pectic acid and sodium Salt such as salt, salt such as alginic acid and sodium salt, mannan; starch such as rice, corn, potato, wheat; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salt, xanthan gum, pullulan, gellan gum, chitin , Chitosan, agar, gypsum extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropi Cellulose, carboxymethylcellulose and its salts such as sodium, methylhydroxypropylcellulose, sodium cellulose sulfate, cellulose dialkyldimethylammonium sulfate, crystalline cellulose, cellulose powder such as cellulose powder; soluble starch, carboxymethyl starch, methylhydroxypropyl starch, Starch-based polymers such as methyl starch, starch derivatives such as hydroxypropyltrimonium chloride, octenyl succinate corn starch and aluminum; alginic acid derivatives such as sodium alginate and propylene glycol alginate; polyvinylpyridone (PVP), polyvinyl alcohol (PVA), Vinyl pydridone-vinyl alcohol copolymer, polyvinyl methyl ether Polyethylene glycol, polypropylene glycol, polyoxyethylene / polyoxypropylene copolymer; amphoteric methacrylic acid such as (methacryloyloxyethylcarboxybetaine / alkyl methacrylate) copolymer, (acrylates / stearyl acrylate / ethylamine methacrylate oxide) copolymer, etc. Ester copolymer; (Dimethicone / vinyl dimethicone) crosspolymer, (alkyl acrylate / diacetone acrylamide) copolymer, (alkyl acrylate / diacetone acrylamide) copolymer AMP; Polyvinyl acetate partial saponification product, maleic acid copolymer; Vinylpyrrolidone / dialkylaminoalkyl methacrylate copolymer; acrylic resin alkanolamine; polyester, water-dispersible polyester; Kurylamide; Polyacrylic acid ester copolymer such as polyethyl acrylate, carboxyvinyl polymer, polyacrylic acid and its sodium salt, acrylic acid / methacrylic acid ester copolymer;

Acrylic acid / methacrylic acid alkyl copolymer; cationic cellulose such as polyquaternium-10, diallyldimethylammonium chloride / acrylamide copolymer such as polyquaternium-7, acrylic acid / diallyldimethylammonium chloride copolymer such as polyquaternium-22 Acrylic acid / diallyldimethylammonium chloride / acrylamide copolymer such as polyquaternium-39, acrylic acid / cationized methacrylic acid ester copolymer, acrylic acid / cationized methacrylic acid amide copolymer, polyquaternium-47, etc. Acrylic acid / methyl acrylate / methacrylamidopropyltrimethylammonium chloride copolymer, methacrylic acid choline ester polymer; cationized oligosaccharide, cationized dextran, Cationic polysaccharides such as arhydroxypropyltrimonium chloride; polyethyleneimine; cationic polymers; copolymers of 2-methacryloyloxyethyl phosphorylcholine such as polyquaternium-51 and copolymers of butyl methacrylate; acrylic resin emulsions , Polymer emulsions such as polyethyl acrylate emulsion, polyacryl alkyl ester emulsion, polyvinyl acetate resin emulsion, natural rubber latex, synthetic latex; nitrocellulose; polyurethanes and various copolymers; various silicones; acrylic-silicone grafts Various silicone-based copolymers such as copolymers; various fluorine-based polymers; 12-hydroxystearic acid and its salts; dextrin palmitate, dextrin myristate Dextrin fatty acid esters; silicic anhydride, fumed silica (ultrafine silica), magnesium aluminum silicate, magnesium magnesium silicate, metal soap, metal dialkyl phosphate, bentonite, hectorite, organically modified clay mineral, Preferred examples include sugar fatty acid esters and fructooligosaccharide fatty acid esters.

Solvents and propellants include ethanol, 2-propanol (isopropyl alcohol), butanol, isobutyl alcohol and other lower alcohols; propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, isopentyl diol and other glycols Diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, dipropylene glycol monoethyl ether Glycol ethers such as ethylene glycol monoethyl ether Glycol ether esters such as acetate, diethylene glycol monoethyl ether acetate, propylene glycol monoethyl ether acetate; Glycol esters such as diethoxyethyl succinate, ethylene glycol disuccinate; benzyl alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate , Acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbon, next-generation flon; propellants such as LPG, dimethyl ether, carbon dioxide, and the like are preferable.

Antioxidants include tocopherol derivatives such as tocopherol (vitamin E) and tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and / or derivatives thereof; erythorbic acid and derivatives thereof; Preferred are sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfites; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, cysteine hydrochloride As mentioned.
Preferred examples of the reducing agent include thioglycolic acid, cysteine, cysteamine and the like.
Preferred examples of the oxidizing agent include aqueous hydrogen peroxide, ammonium persulfate, sodium bromate, and percarbonate.

Examples of the antiseptic / antibacterial agent other than the antiseptic antibacterial agent of the present invention include hydroxybenzoic acid such as methylparaben, ethylparaben, propylparaben and butylparaben and salts or esters thereof; salicylic acid; sodium benzoate; phenoxyethanol; 1,2-diols such as pentanediol and 1,2-hexanediol; isothiazolinone derivatives such as methylchloroisothiazolinone and methylisothiazolinone; imidazolinium urea; dehydroacetic acid and its salts; phenols; Halogenated bisphenols, acid amides, quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, benzalkonium chloride, benzethonium chloride, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban Hexachlorophene, hinokitiol; other phenols such as phenol, isopropylphenol, cresol, thymol, parachlorophenol, phenylphenol, sodium phenylphenol; phenylethyl alcohol, photosensitizers, antibacterial zeolite, silver ion are preferred. .
Examples of chelating agents include edetate (ethylenediaminetetraacetate) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediaminetriacetate such as HEDTA3Na; pentetate (diethylenetriaminepentaacetate); phytic acid; Phosphonic acid and its sodium salt; sodium oxalate; polypolyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine Gluconic acid, ascorbic acid, succinic acid, and tartaric acid are preferable.
pH adjusters / acids / alkalis include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanol Amine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, hydroxylation Sodium, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate are preferable.

Examples of powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, red mica, biotite, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, silica Barium acid, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluorine apatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, Metal soap (eg, zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, bengara, yellow iron oxide, black iron oxide, ultramarine, bitumen, carbon black, titanium oxide, fine particles and super Titanium oxide, zinc oxide, fine and ultrafine zinc oxide, alumina, silica, fumed silica (ultrafine silica), mica titanium, fish scale foil, boron nitride, photochromic pigment, synthetic fluorophlogopite, fine particle composite powder Body, gold, aluminum, etc., various sizes and shapes of inorganic powders, and these are treated with various surface treatment agents such as hydrogen silicone, cyclic hydrogen silicone, or other silane or titanium coupling agents Inorganic powders such as hydrophobized or hydrophilized powders; starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, polyester powder, Benzoguanamine resin powder, polyethylene terephthalate polymer Organic powders and surface-treated powders of various sizes and shapes, such as polyurethane powder, polyethylene terephthalate / aluminum / epoxy powder, urethane powder, silicone powder, Teflon (registered trademark) powder, organic-inorganic composite powder The body is preferred.
Inorganic salts include sodium chloride-containing salts such as salt, common salt, rock salt, sea salt, natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, Aluminum sulfate / potassium sulfate (alum), aluminum sulfate / ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as 1Na, 2Na and 3Na phosphates, phosphoric acid Potassium, calcium phosphates and magnesium phosphates are preferred.

Examples of ultraviolet absorbers include paraaminobenzoic acid, paraaminobenzoic acid monoglycerin ester, N, N-dipropoxyparaaminobenzoic acid ethyl ester, N, N-diethoxyparaaminobenzoic acid ethyl ester, and N, N-dimethylparaaminobenzoic acid ethyl ester. Benzoic acid-based ultraviolet absorbers such as esters, N, N-dimethylparaaminobenzoic acid butyl ester, N, N-dimethylparaaminobenzoic acid ethyl ester; Anthranilic acid-based ultraviolet absorbers such as homomenthyl-N-acetylanthranilate; Salicylic acid And salicylic acid-based purple such as sodium salt, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate Line absorber: Octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p- Methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, 2-ethylhexyl p-methoxycinnamate (octyl paramethoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate (sinoxate), Cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl α-cyano-β-phenylcinnamate (octocrine), glyceryl mono-2-ethylhexanoyl-diparamethoxy Cinnamic acid UV absorbers such as cinnamate, ferulic acid and derivatives thereof; 2,4-dihydroxybenzophenone, 2,2′-dihydroxy-4-methoxybenzophenone, 2,2′-dihydroxy-4,4′-dimethoxybenzophenone, 2,2 ′, 4,4′-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4′-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone -5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone, etc. Benzophenone UV absorber; 3- (4′-methylbenzylidene) -d, l-camphor, 3-benzylidene-d, l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2′-hydroxy-5 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole; 2- (2′-hydroxy-5′-methylphenylbenzotriazole; dibenzalazine; dianisoylmethane; 5- (3 , 3-dimethyl-2-norbornylidene) -3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; octyl triazone; urocanic acid derivatives such as urocanic acid and ethyl urocanate; 2- (2′-hydroxy-5′-methylphenyl) benzotriazole, 1 Hydantoin derivatives such as (3,4-dimethoxyphenyl) -4,4-dimethyl-1,3-pentanedione, dimethoxybenzylidenedioxoimidazolidinepropionate 2-ethylhexyl, phenylbenzimidazolazolesulfonic acid, terephthalylidene diene Preference is given to camphorsulfonic acid, drometrizole trisiloxane, methyl anthranilate, rutin and its derivatives, oryzanol and its derivatives.

Examples of whitening agents include hydroquinone glycosides such as arbutin and α-arbutin and esters thereof; ascorbic acid phosphate salts such as ascorbic acid, sodium ascorbate phosphate and magnesium ascorbate phosphate, ascorbic acid Ascorbic acid fatty acid esters such as tetraisopalmitic acid ester, ascorbic acid alkyl ethers such as ascorbic acid ethyl ether, ascorbic acid glucosides such as ascorbic acid-2-glucoside and fatty acid esters thereof, ascorbic acid sulfate ester, tocopheryl ascorbyl phosphate Ascorbic acid derivatives such as kojic acid, ellagic acid, tranexamic acid and its derivatives, ferulic acid and its derivatives, placenta extract, glutathione, oryzanol, butylreso Shinoru, oil-soluble Kamomiraekisu, oil-soluble licorice extract, Nishikawa willow extract, be mentioned as saxifrage extract, and the like plant extracts are preferred.

Vitamins and their derivatives include vitamin A such as retinol, retinol acetate, retinol palmitate; thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, Flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinic acid such as nicotinic acid amide / benzyl nicotinate, vitamin B group such as choline; vitamin C such as ascorbic acid and its sodium salt; vitamin D; α, Vitamin Es such as β, γ, δ-tocopherol; other vitamins such as pantothenic acid and biotin; ascorbic acid phosphates such as ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium salt; Ascorbic acid fatty acid esters such as corobic acid tetraisopalmitic acid ester, ascorbyl stearate, ascorbyl palmitate and ascorbyl dipalmitate, ascorbic acid alkyl ether such as ascorbic acid ethyl ether, ascorbic acid glucoside such as ascorbic acid-2-glucoside and Ascorbic acid derivatives such as fatty acid esters and tocopheryl phosphate ascorbyl; vitamin derivatives such as tocopherol nicotinate, tocopherol acetate, tocopherol acetate, tocopherol linoleate, tocopherol phosphate, tocopherol phosphate etc., tocotrienol, and other various vitamin derivatives Is preferable.

Anti-inflammatory and anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, diphedramine hydrochloride, chlorpheniramine maleate; peach leaf extract A plant extract such as a koji leaf extract is preferable.

Plant growth and tinctures such as assembly extract, red pepper tincture, ginger tincture, ginger extract, cantalis tincture; capsaicin, nonyl acid valenylamide, gingeron, ictamol, tannic acid Borneol, cyclandelate, cinnarizine, trazoline, acetylcholine, verapamil, cephalanthin, γ-oryzanol, cephalanthin, vitamin E and nicotinic acid tocopherol, acetic acid tocopherol and other derivatives, γ-oryzanol, nicotinic acid, nicotinic acid amide, nicotinic acid benzyl Derivatives such as ester, inositol hexanicotinate, nicotine alcohol, allantoin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, Preferable examples include flavonol derivatives, stigmasterol or stigmasteranol, its glycosides, and minoxidil.
Preferred hormones include estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisone and the like.

Other remedies such as anti-wrinkle agents, anti-aging agents, squeeze agents, cooling sensations, warming sensation agents, wound healing promoters, irritation relievers, analgesics, cell activators include retinols, retinoic acids, retinoin Acid tocopheryl; derivatives such as lactic acid, glycolic acid, gluconic acid, fruit acid, salicylic acid and glycosides / esterified products thereof, α- or such as hydroxycapric acid, long chain α-hydroxy fatty acid, long chain α-hydroxy fatty acid cholesteryl β-hydroxy acids and derivatives thereof; γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid; carnitine; creatine; ceramides, sphingosines; caffeine, xanthine and the like; and coenzyme Q10, carotene, lycopene, astaxanthin Antioxidant / active oxygen scavengers such as α-lipoic acid; catechins; flavins such as quercetin Bonnes; isoflavones; gallic acid and ester sugar derivatives; polyphenols such as tannin, sesamin, protoanthocyanidins, chlorogenic acid and apple polyphenol; derivatives such as rutin and glycosides; derivatives such as hesperidin and glycosides; Sugar bodies; licorice extract-related substances such as grabrizine, glabrene, liquiritin, and isoliquiritin; lactoferrin; gingerol; fragrance substances such as menthol, camphor, cedrol, and derivatives thereof; capsaicin, vanillin, and derivatives; insects such as diethyltoluamide A repellent; a complex of a physiologically active substance and cyclodextrins is preferable.

As plant / animal / microbe extracts, Iris extract, Ashitaba extract, Asunaro extract, Asparagus extract, Avocado extract, Achacha extract, Almond extract, Altea extract, Arnica extract, Aloe extract, Apricot extract, Ginkgo biloba extract, Ginkgo biloba extract , Incheon extract, Fennel extract, Turmeric extract, Oolong tea extract, Peony extract, Ages extract, Echinacea leaf extract, Enmeo extract, Ogon extract, Oat extract, Auren extract, Barley extract, Panax ginseng extract, Hypericum extract, Odori extract , Dutch mustard extract, orange extract, dried sea water, seaweed extract, oyster leaf extract, oyster extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolysis Luc, Cascon extract, Chamomile extract, Oil-soluble chamomile extract, Carrot extract, Kawara mugi extract, Oat extract, Calcade extract, Licorice extract, Oil-soluble Licorice extract, Kiwi extract, Kiou extract, Cyprid extract, Quina extract, Cucumber extract, Kiri leaf extract, Guanosine, guava extract, cucumber extract, gardenia extract, kumazasa extract, clara extract, walnut extract, chestnut extract, grapefruit extract, clematis extract, black rice extract, brown sugar extract, black vinegar, chlorella extract, mulberry extract, gentian extract, Gentian pepper extract, tea Extract, yeast extract, kokuboku extract, coffee extract, burdock extract, rice extract, rice fermented extract, rice bran fermented extract, rice germ oil, comfrey extract, Lagen, Cowberry extract, Saishin extract, Psycho extract, Saitai extract, Saffron extract, Salvia extract, Salmon extract, Sasa extract, Hawthorn extract, Sansha extract, Salamander extract, Shiitake extract, Giant extract, Shikon extract, Perilla extract, Linden extract, Shimosukeso Extract, jatoba extract, peonies extract, ginger cucumber extract, ginger root extract, white birch extract, white jellyfish extract, horsetail extract, stevia extract, stevia fermented product, west river willow extract, horse chestnut extract, hawthorn extract, elderberry extract, yarrow extract , Mint extract, sage extract, mallow extract, nematode extract, essence extract, Sakuhakuhi extract, Diou extract, Dai Extract, peanut extract, thyme extract, dandelion extract, lichen extract, tea extract, clove extract, chigaya extract, chimpi extract, tea tree oil, tea tea extract, red pepper extract, red snapper extract, red snapper extract, red spruce extract, red spruce extract, tomato Extract, natto extract, carrot extract, garlic extract, wild rose extract, hibiscus extract, bacmond extract, lotus extract, parsley extract, birch extract, honey, hamamelis extract, parietalia extract, hyacinth extract, bisabolol, cypress extract, bifidobacteria extract, Loquat extract, dandelion extract, burdock extract, bukkuri extract, butcher bloom extract, grape extract, grape seed extract, propolis, loofah extract, Safflower extract, peppermint extract, body extract, button extract, hop extract, squid extract, pine extract, maroonnier extract, mizubasho extract, mukuroji extract, melissa extract, mozuku extract, peach extract, cornflower extract, eucalyptus extract, yukinoshita extract, yuzu extract, lily extract, Yokuinin extract, mugwort extract, lavender extract, green tea extract, eggshell membrane extract, apple extract, rooibos tea extract, litchi extract, lettuce extract, lemon extract, forsythia extract, forsythia extract, rose extract, rosemary extract, roman chamomile extract, royal jelly Extracts such as an extract and a bitumen extract are preferred.

Examples of the antipruritic agent include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance-P inhibitor, and the like.
Examples of the exfoliating / dissolving agent include salicylic acid, sulfur, resorcin, selenium sulfide, pyridoxine and the like.
Examples of the antiperspirant include chlorohydroxyaluminum, aluminum chloride, zinc oxide, and zinc paraphenol sulfonate.
Examples of the refreshing agent include menthol and methyl salicylate.
Examples of the astringent include citric acid, tartaric acid, lactic acid, aluminum sulfate / potassium sulfate, and tannic acid.
Examples of enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease, and the like.
Preferred nucleic acids include ribonucleic acid and salts thereof, deoxyribonucleic acid and salts thereof, and adenosine triphosphate disodium.

As perfumes, acetyl cedrene, amylcinnamaldehyde, allyl amyl glycolate, β-ionone, iso-Esuper, isobutyl quinoline, Iris oil, Iron, indole, ylang ylang oil, undecanal, undecenal, γ-undecalactone, Estragole, eugenol, oak moss, opoponax resinoid, orange oil, eugenol, auranthiol, galac solid, carvacrol, L-carvone, camphor, cannon, carrot seed oil, clove oil, methyl cinnamate, geraniol, geranyl nitrile , Isobornyl acetate, geranyl acetate, dimethylbenzyl carvinyl acetate, styrylyl acetate, cedolyl acetate, terpinel acetate, pt-butylcyclohexyl acetate, vetiberyl acetate, benzyl acetate Linalyl acetate, isopentyl salicylate, benzyl salicylate, sandalwood oil, santalol, cyclamenaldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromyrsenol, jasmine absolute, jasmine lactone, cis-jasmon, citral, citronenol, Citronellal, cinnamon bark oil, 1,8-cineole, cinnamaldehyde, stylax resinoid, cedarwood oil, cedrene, cedrol, celery seed oil, thyme oil, damascon, damassenone, thymol, tuberose absolute, decanal, decalactone, terpineol, γ- Terpinene, triplar, nerol, nonanal, 2,6-nonadienol, nonalactone, patchouli alcohol, vanilla Solute, vanillin, basil oil, patchouli oil, hydroxycitronellal, α-pinene, piperitone, phenethyl alcohol, phenylacetaldehyde, petitglen oil, hexylcinnamaldehyde, cis-3-hexenol, perubalsum, vetiver oil, vetiverol, peppermint oil , Pepper oil, heliotropin, bergamot oil, benzyl benzoate, borneol, milresinoid, musk ketone, methyl nonyl acetaldehyde, γ-methyl ionone, menthol, L-menthol, L-menthol, eucalyptus oil, β-ionone, lime oil, lavender oil Synthetic and natural fragrances such as D-limonene, linalool, linal, rillial, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, and various essential oils In addition, various kinds of blended fragrances are preferable.

As pigments / colorants / dyes / pigments, brown 201, black 401, purple 201, purple 401, blue 1, blue 2, blue 201, blue 202, blue 203, blue 204 , Blue 205, Blue 403, Blue 404, Green 201, Green 202, Green 204, Green 205, Green 3, Green 401, Green 402, Red 102, Red 104-1 , Red 105-1, Red 106, Red 2, Red 201, Red 202, Red 203, Red 204, Red 205, Red 206, Red 207, Red 208, Red 213 Red 214, Red 215, Red 218, Red 219, Red 220, Red 221, Red 223, Red 225, Red 226, Red 227, Red 228, Red 230 No. 1, Red 230-2, Red 231, Red 232, Red 3, Red 401, Red 404, Red 405, Red 501, Red 502, Red 503, Red 504, Red 505, red 506, orange 201, orange 203, orange 204, orange 205, orange 206, orange 207, orange 401, orange 402, orange 403, yellow 201, yellow 202- No. 1, yellow 202-2, yellow 203, yellow 204, yellow 205, yellow 4, yellow 401, yellow 402, yellow 403-1, yellow 404, yellow 405, yellow 406 Legal pigments such as Yellow No. 407 and Yellow No. 5; Other acidic dyes such as Acid Red 14;

Base dyes such as Aryanor Sienna Brown, Aryanor Madder Red, Aryanor Steel Blue, Aryanor Straw Yellow, etc .; HC Yellow 2, HC Yellow 5, HC Red 3, 4-hydroxypropylamino 3-nitro-ol Nitro dyes such as 2-nitro-p-phenylenediamine, HC Blue 2, Basic Blue 26; disperse dyes; inorganic white pigments such as titanium dioxide and zinc oxide; inorganic red pigments such as iron oxide (bengala) and iron titanate; Inorganic brown pigments such as γ-iron oxide; Inorganic yellow pigments such as yellow iron oxide and ocher; Inorganic black pigments such as black iron oxide and low-order titanium oxide; Inorganic purple pigments such as Ngo violet and cobalt violet; inorganic green pigments such as chromium oxide, chromium hydroxide and cobalt titanate; inorganic blue pigments such as ultramarine and bitumen; titanium oxide coated mica and titanium oxide coated bismuth oxychloride Pearl pigments such as titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, fish scale foil; metal powder pigments such as aluminum powder, copper powder and gold; surface treatment inorganic and metal powder pigments; red 201, red 202 No., Red No. 204, Red No. 205, Red No. 220, Red No. 226, Red No. 228, Red No. 405, Orange No. 203, Orange No. 204, Yellow No. 205, Yellow No. 401, Blue No. 404, Red No. 3, Red 104, Red 106, Red 227, Red 230, Red 40 No., Red No. 505, Orange No. 205, Yellow No. 4, Yellow No. 5, Yellow No. 202, Yellow No. 203, Green No. 3, Blue No. 1, etc., organic pigments such as zirconium, barium or aluminum lakes; surface treated organic pigments Anthraquinones such as astaxanthin and alizarin, anthocyanidin, β-carotene, catenal, capsanthin, chalcone, calsamine, quercetin, naphthoquinones such as crocin, chlorophyll, curcumin, cochineal, shikonin, bixin, flavones, betacyanidine, henna, hemoglobin Natural pigments and dyes such as lycopene, riboflavin, rutin; p-phenylenediamine, toluene-2,5-diamine, o-, m-, or p-aminophenol, m-phenylenediamine, 5-amino-2-methyl Phenol, resorci Preferred examples include oxidative dye intermediates and couplers such as chloroquine, 1-naphthol, 2,6-diaminopyridine, and salts thereof; autooxidative dyes such as indoline; and dihydroxyacetone.

Preferred examples of water include normal water, purified water, hard water, soft water, natural water, deep sea water, electrolytic alkaline ionized water, electrolytic acidic ionized water, ionic water, and clustered water.
In addition to these, cosmetic raw material standards, blending ingredient standard by cosmetic varieties, Japan Cosmetic Industry Association ingredient display name list, INCI dictionary (The International Cosmetic Ingredient and Handbook), quasi-drug raw material standards, Japanese pharmacopoeia, pharmaceutical additives Standards, ingredients listed in the Food Additives, etc., and international patent classification IPC described in Japan and foreign patent gazettes and patent publications (including publications and republications) belonging to the A61K7 classification It is possible to contain known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc., in known combinations, blending ratios and blending amounts.

The types of cosmetics and skin external preparations of the present invention will be described in more detail. Basic cosmetics include soft lotions, astringent lotions, cleansing lotions, multi-layer lotions, etc .; emollient lotions, moisture Lotion, Milky Lotion, Nourishing Lotion, Nourishing Milk, Skin Moisture, Moisturizer Emulsion, Massage Lotion, Cleansing Lotion, Protect Emulsion, Sun Protect, Sun Protector, UV Care Milk, Sun Screen, Makeup Lotion, Horny Smoother, Elbow Milky lotion, hand lotion, body lotion, etc .; emollient cream, nourishing cream, nourishing cream, burnishing cream, moisture cream, night cream, massage cream Cleansing cream, makeup cream, base cream, pre-makeup cream, sunscreen cream, suntan cream, hair removal cream, deodorant cream, shaving cream, keratin softening cream, etc .; Moisture gel, etc .; Moisturizing essence, whitening essence, UV Essences such as prevention essences; Liposome cosmetics such as liposome cosmetics and liposome lotions; Packs and masks such as peel-off packs, powder packs, washing packs, oil packs, cleansing masks; cleansing foams, cleansing creams, cleansing milks, cleansings Facial cleansers such as lotions, cleansing gels, cleansing oils, cleansing masks, washing powders, face washing powders, cosmetic soaps, Akira soap, medicated soap, liquid soap, shaving soap, be mentioned as soaps and synthetic toilet soaps are preferred.

Examples of makeup cosmetics that may be preferably used include white powder, dusts, foundations, lipsticks, lip gloss, blushers, eyeliner, mascara, eye shadow, eyebrow, eyebrow, nail enamel, enamel remover, and nail treatment.
Preferred examples of the aromatic cosmetics include perfume, perfume, parfum, eau de parfum, eau de toilette, eau de cologne, perfumes, fragrance powder, perfume soap, body lotion and bath oil.
Body cosmetics such as body shampoos; deodorant lotions, deodorant powders, deodorant sprays, deodorant sticks and other deodorant cosmetics; decoloring agents, hair removal / hair removal agents; bathing agents; insect repellents A repeller is preferred.

Cosmetics for hair include oil shampoo, cream shampoo, conditioning shampoo, dandruff shampoo, hair color shampoo, shampoo with integrated rinse, shampoo for rinse, treatment, hair pack, color lotion, split coat, permanent wave Preference is given to agents, straight perm agents, oxidative hair dyes, hair bleaches, hair color pre-treatments, hair color after treatments, perm pre-treatments, perm after treatments, hair manicures, hair tonics and hair restorers.

As an external preparation for skin, it can be used as a dosage form such as an ointment, a patch, a lotion, a liniment, and a liquid coating agent. It can also be used as an oral cosmetic such as toothpaste and mouthwash.
As the dosage form of the cosmetic or external preparation for skin of the present invention, emulsification such as oil-in-water (O / W) type, water-in-oil (W / O) type, W / O / W type, O / W / O type, etc. Type cosmetics, oily cosmetics, solid cosmetics, liquid cosmetics, paste cosmetics, stick cosmetics, volatile oil cosmetics, powder cosmetics, jelly cosmetics, gel cosmetics, pastes Preferred examples include cosmetics, emulsified polymer cosmetics, sheet cosmetics, mist cosmetics, and spray cosmetics.

The antiseptic antibacterial agent of the present invention has the above-described configuration and can exhibit a higher antiseptic antibacterial effect than conventional antiseptic antibacterial agents. Therefore, basic cosmetics, makeup cosmetics, aromatic cosmetics, body cosmetics, ointments It can be suitably used for external preparations for skin, hair cosmetics and the like.

The present invention will be described in more detail with reference to the following examples. However, the present invention is not limited to these examples. Unless otherwise specified, “part” means “part by weight” and “%” means “mass%”.

<Gel permeation chromatography (GPC)>
The weight average molecular weight (Mw) of the copolymer was measured by GPC (gel permeation chromatography).
The measurement conditions and apparatus are as follows.
Equipment: EcoSEC HLC-8320GPC manufactured by Tosoh Corporation
Detector: Differential refractometer (RI) detector Column: TSKgel α-M, α-2500 manufactured by Tosoh Corporation
Column temperature: 40 ° C
Flow rate: 0.4 mL / min
Injection volume: 20 μL (eluent preparation solution with sample concentration of 0.4 wt%)
Calibration curve: GL Sciences polyethylene glycol GPC software: Tosoh EcoSEC-WS
Eluent: 0.5M acetic acid + 0.2M Na nitrate / acetonitrile = 50/50 (v / v)

<Minimum growth inhibitory concentration (MIC)>
The aqueous solution containing the antiseptic antibacterial agent was sequentially diluted two-fold in the Mueller Hinton medium to prepare a dilution series of the antiseptic antibacterial agent-containing medium. Thereafter, 50 μL of a medium containing antiseptic antibacterial agent at each concentration was added to a 96-well plate made of polystyrene. Next, E. coli (Escherichia coli, NBRC-15034, NBRC-3972), Staphylococcus aureus (NBRC-15035, NBRC-13276) and Pseudomonas aeruginus (Pseudomonas aerugin) grown on Mueller Hinton agar medium for 18 hours. , NBRC-13275) colonies were suspended in a butterfield buffer solution to prepare about 10 × 10 ⁸ cells / mL bacterial solution. The prepared bacterial solution was diluted to about 10 × 10 ⁶ cells / mL in Mueller Hinton medium, and 50 μL was added to the dilution series prepared above. After standing at 35 ° C. for 20 hours, the minimum antibacterial and antibacterial agent concentration (ppm) in the medium in which the bacteria did not grow was determined as the minimum growth inhibitory concentration (MIC). The presence or absence of the growth of the fungus was judged based on whether the turbidity was increased visually.
The results are shown in Tables 1 and 2.

<Preservation test 1>
A potato dextrose agar (PDA) medium containing 2000 ppm of the copolymer (preservative antibacterial agent) synthesized in Synthesis Examples 1 to 5 below was prepared.
A pre-cultured culture solution prepared by diluting Aspergillus brasiliensis ATCC 16404 (Agaricus mildew) to about 10 ⁷ cells / mL is prepared as a bacterial suspension, and the suspension is added to 15 ml of the PDA medium containing the antiseptic antibacterial agent. .15 ml was mixed and statically cultured at 25 ° C. for 7 days, and the presence or absence of colony formation in the cultured PDA medium was confirmed.
The results are shown in Table 3.

<Preservation test 2: (Challenge test using O / W cream sample and lotion sample (preservation efficacy test))>
The copolymer (antiseptic antibacterial agent) synthesized in Synthesis Examples 1 to 3 and other components were blended as shown in Table 4 to prepare a cream.
The copolymer (preservative antibacterial agent) synthesized in Synthesis Examples 4 and 5 and other components were blended as shown in Table 6 to prepare a lotion.
The copolymer (preservative antibacterial agent) synthesized in Synthesis Examples 8 and 9 and other components were blended as shown in Table 8 to prepare a lotion.
About the said cream and lotion, the challenge test by the following method was done and antiseptic power was evaluated.
For the following bacterial species, a pre-cultured culture solution diluted to about 10 ⁸ cells / mL for bacteria and Candida and about 10 ⁷ cells / mL for Aspergillus was used as a cell suspension. The number of bacteria in the suspension was confirmed by the colony count method.
Bacteria: Escherichia coli (NBRC-3972), Staphylococcus aureus (NBRC-13276), Pseudomonas aeruginosa (NBRC-13275)
Yeast: Candida (Candia albicans ATCC 10231)
Mold: Aspergillus brasiliensis ATCC 16404
20 g of the prepared cream or lotion was put in a dry sterilized glass container, 0.2 ml of the above bacterial suspension was inoculated, and cultured at 25 ° C. After 2, 7, 14, and 21 days, 1 g of each sample was withdrawn, and the sample diluted with physiological saline was mixed in an agar medium. Bacteria and Candida were cultured for 48 hours, and Aspergillus niger were cultured for 7 days. Thus, the number of remaining bacteria in the sample was calculated.
The results are shown in Tables 5, 7, and 9.

<Synthesis Example 1>
A glass separable flask equipped with a thermometer, a reflux condenser, and a stirrer was charged with 90.0 g of pure water and heated to 90 ° C. with stirring. Subsequently, 2- (dimethylamino) ethyl methacrylate (N, N-dimethylaminoethyl methacrylate) (manufactured by Wako Pure Chemical Industries, Ltd., hereinafter referred to as DAM) 51 was placed in a polymerization reaction system at a constant temperature of 90 ° C. with stirring. Monomer solution 1 consisting of .3 g, acetic acid 18.6 g and ethyl methacrylate (hereinafter referred to as EMA) 8.56 g; 2,2′-azobis (2-methylpropionamidine) dihydrochloride (Wako Pure Chemical Industries, Ltd.) ), And hereinafter referred to as V-50) An aqueous initiator solution composed of 29.3 g of a 2.5% aqueous solution; a monomer solution 2 composed of 25.7 g of DAM and 9.32 g of acetic acid were dropped from separate dropping nozzles.
Regarding the dropping start time, the monomer solution 1 and the aqueous initiator solution started to be dropped simultaneously, and the monomer solution 1 was dropped for 120 minutes and the aqueous initiator solution was dropped for 210 minutes. The monomer solution 2 was dropped over 60 minutes after the completion of dropping of the monomer solution 1. After completion of the dropwise addition, the reaction solution was further aged at 90 ° C. for 30 minutes to complete the polymerization, and copolymer 1 was obtained.
The obtained copolymer had a solid content of 36.8%, a pH of 6.41, and a weight average molecular weight of 44900.

<Synthesis Example 2>
A copolymer 2 was obtained by polymerization in the same manner as in Synthesis Example 1 except that EMA was changed to butyl acrylate (hereinafter referred to as BA).
The obtained copolymer 2 had a solid content of 35.7%, a pH of 6.41, and a weight average molecular weight of 45200.

<Synthesis Example 3>
A glass separable flask equipped with a thermometer, a reflux condenser, and a stirrer was charged with 50 g of pure water and 22 g of propylene glycol, and heated to 90 ° C. with stirring. Next, in a polymerization reaction system at a constant temperature of 90 ° C. with stirring, a monomer solution 1 consisting of 63 g of DAM, 24.1 g of acetic acid and 22.5 g of BA; an initiator aqueous solution consisting of 31.9 g of 5% aqueous solution of V-50; 18% acrylic A monomer solution 2 composed of 25.6 g of an acid (hereinafter also referred to as AA) aqueous solution was dropped from separate dropping nozzles. Regarding the dropping start time, the monomer solution 1 was dropped for 180 minutes, and the aqueous initiator solution and the monomer solution 2 were dropped for 210 minutes.
After completion of the dropwise addition, the reaction solution was further aged at 90 ° C. for 30 minutes to complete the polymerization, whereby a copolymer 3 was obtained.
The obtained copolymer 3 had a solid content of 34.9%, a pH of 6.15, and a weight average molecular weight of 49500.

<Synthesis Example 4>
A glass separable flask equipped with a thermometer, a reflux condenser, and a stirrer was charged with 70 g of 1,3-butanediol and heated to 90 ° C. with stirring. Next, under stirring, in a polymerization reaction system at a constant temperature of 90 ° C., a monomer solution consisting of 73.8 g of DAM and 13.5 g of EMA, an initiator aqueous solution consisting of 21.9 g of a 7% aqueous solution of V-50, 18.3% acrylic acid Monomer solution 2 composed of 14.7 g of aqueous solution was dropped from separate dropping nozzles.
Regarding the dropping start time, the monomer solutions 1 and 2 were dropped for 180 minutes, and the aqueous initiator solution and the monomer solution 2 were dropped for 210 minutes.
After completion of the dropwise addition, the reaction solution was kept at 90 ° C. for aging for 90 minutes to complete the polymerization. 50 g of pure water was added to obtain a copolymer 4.
The obtained copolymer 4 had a solid content of 35.2%, a pH of 9.0, and a weight average molecular weight of 30,500.

<Synthesis Example 5>
A glass separable flask equipped with a thermometer, a reflux condenser, and a stirrer was charged with 60 g of 1,3-butanediol and heated to 90 ° C. with stirring. Next, in a polymerization reaction system at a constant temperature of 90 ° C. with stirring, a monomer solution consisting of 81 g of DEAM 1: an initiator aqueous solution consisting of 28.1 g of 5% aqueous solution of V-50, and 21.3 g of 42.4% aqueous acrylic acid solution The resulting monomer solution 2 was dropped from separate dropping nozzles.
Regarding the dropping start time, the monomer solutions 1 and 2 were dropped for 180 minutes, and the aqueous initiator solution and the monomer solution 2 were dropped for 210 minutes.
After completion of the dropwise addition, the reaction solution was kept at 90 ° C. for aging for 90 minutes to complete the polymerization. 50 g of pure water was added to obtain a copolymer 5.
The obtained copolymer 5 had a solid content of 32.9%, a pH of 8.8, and a weight average molecular weight of 22,000.

<Synthesis Example 6>
A glass separable flask equipped with a thermometer, a reflux condenser, and a stirrer was charged with 24.0 g of pure water and 72 g of propylene glycol (hereinafter also referred to as PG), and heated to 90 ° C. with stirring. Next, in a polymerization reaction system at a constant temperature of 90 ° C. with stirring, a monomer solution 1 consisting of 54 g of DAM and 20.6 g of acetic acid; an initiator aqueous solution consisting of 32.5 g of a 2.5% aqueous solution of V-50; butyl acrylate (BA) The monomer solution 2 consisting of 36 g was dropped from separate dropping nozzles. Regarding the dropping time, the monomer solutions 1 and 2 and the aqueous initiator solution started dropping simultaneously, the monomer solutions 1 and 2 were dropped for 180 minutes, and the aqueous initiator solution was dropped for 210 minutes. After completion of the dropwise addition, the reaction solution was further aged at 90 ° C. for 90 minutes to complete the polymerization, whereby a copolymer 6 was obtained.
The obtained copolymer 6 had a solid content of 35.2% and a weight average molecular weight of 22,100.

<Synthesis Example 7>
Polymerization was carried out in the same manner as in Synthesis Example 6 except that BA in the monomer solution 2 of Synthesis Example 6 was changed to 2-ethylhexyl acrylate (2EHA) to obtain a copolymer 7. The obtained copolymer 7 had a solid content of 36.4% and a weight average molecular weight of 70700.

<Synthesis Example 8>
Instead of propylene glycol, 50 g of pure water and 30 g of 1,3-butanediol (1,3-BG) were charged, and the temperature was raised to 90 ° C. with stirring. Next, under stirring, a monomer solution composed of 72 g of DAM, 27.52 g of acetic acid and 18 g of butyl acrylate; an aqueous initiator solution composed of 29.9 g of a 5% aqueous solution of V-50 were separately added dropwise to a polymerization reaction system at a constant temperature of 90 ° C. It dripped from the nozzle. The monomer solutions 1 and 2 were dropped for 180 minutes and the initiator aqueous solution was dropped for 210 minutes. After completion of the dropwise addition, the reaction solution was further aged at 90 ° C. for 90 minutes, and 50 g of pure water was added to complete the polymerization, thereby obtaining a copolymer 8. The obtained copolymer 8 had a solid content of 31.2% and a weight average molecular weight of 24900.

<Synthesis Example 9>
A glass separable flask equipped with a thermometer, a reflux condenser, and a stirrer was charged with 42.0 g of pure water and 28 g of 1,3-BG, and heated to 90 ° C. with stirring. Next, a monomer solution consisting of 67.5 g of DAM, 25.8 g of acetic acid and 18 g of ethyl methacrylate, and an initiator aqueous solution consisting of 22.6 g of a 7% aqueous solution of V-50; A monomer solution 2 composed of 16.5 g of a 3% AA aqueous solution was dropped from separate dropping nozzles. Regarding the dropping time, the monomer solutions 1 and 2 and the aqueous initiator solution started to be dropped simultaneously, the monomer solutions 1 and 2 were dropped for 120 minutes, and the aqueous initiator solution was dropped for 150 minutes. After the completion of the dropwise addition, the reaction solution was further aged at 90 ° C. for 90 minutes, and 50 g of pure water was added to complete the polymerization, whereby a copolymer 9 was obtained.
The obtained copolymer 9 had a solid content of 32% and a weight average molecular weight of 30,200.

<Examples 1 to 10 and Comparative Examples 1 and 2: MIC>
MIC was evaluated about the copolymers 1-9 obtained by the synthesis examples 1-9 and the methylparaben and phenoxyethanol as a comparative example, and the evaluation result was shown to Table 1 and 2. FIG.

<Examples 11 to 15 and Comparative Example 3: Preservation Test 1>
Preservation test 1 was performed on the copolymers 1 to 5 obtained in Synthesis Examples 1 to 5, and the evaluation results are shown in Table 3. In Comparative Example 3, the same test was performed without using the antiseptic antibacterial agent. The evaluation results are shown in Table 3.

<Examples 16 to 18 and Comparative Examples 4 and 5: Preservation Test 2>
Preservation test 2 was performed on the creams prepared as shown in Table 4, and the evaluation results are shown in Table 5.

<Examples 19 and 20 and Comparative Examples 6 and 7: Preservation Test 2>
The antiseptic test 2 was conducted on the lotions prepared as shown in Table 6, and the evaluation results are shown in Table 7.

<Examples 21 and 22 and Comparative Example 8: Preservation Test 2>
The antiseptic test 2 was performed on the lotions prepared as shown in Table 8, and the evaluation results are shown in Table 9.

<Example 23 and Comparative Example 9: Emulsification performance test>
(Example 23)
5 g of olive oil, 44.4 g of water, and 0.66 g of copolymer 2 obtained in Synthesis Example 2 were added, and the mixture was emulsified by stirring with a homomixer at 8000 rpm for 10 minutes. It was 210 nm when the particle diameter of the emulsified liquid was measured by a particle diameter measuring device (concentrated analyzer FPAR-1000; manufactured by Otsuka Electronics Co., Ltd.).
(Comparative Example 9)
An emulsion performance test was conducted in the same manner as in Example 16 except that 0.66 g of copolymer 2 was changed to 0.25 g of nonionic surfactant NC2305 (manufactured by Nippon Emulsifier). 450 nm.
Further, when the emulsions of Example 23 and Comparative Example 9 were allowed to stand at room temperature for 1 week, Comparative Example 9 was separated and the emulsified state was broken, whereas Example 23 was emulsified. The state was maintained. From the above, it has been clarified that the material of the present invention can be finely dispersed as compared with existing surfactants and further has excellent dispersion stability.

Tables 10 to 17 below describe formulation examples of the cosmetics of the present invention. In addition, when the antiseptic test 2 was implemented to the cosmetics composition of this invention in these prescription examples, in any prescription example, antibacterial activity value (antibacterial activity value = log (viable cell count at the time of inoculation) -log (after 7 days) The number of viable bacteria, however, was 14 or more after 14 days), and the evaluation was “good”.

Formulation Examples 1-3 Whitening Lotion

＊１ 加水分解卵隔膜水溶液（キューピー社製）
＊２ 酵母エキス（山川貿易社製）

* 1 Hydrolyzed egg diaphragm aqueous solution (manufactured by Kewpie)
* 2 Yeast extract (manufactured by Yamakawa Trading Co., Ltd.)

(Manufacturing method) The raw material which belongs to A was heated at 70 degreeC, and it melt | dissolved completely, Then, it cooled to room temperature. Then, the raw material which belongs to B was mixed, and the whitening lotion was obtained.

Formulation Examples 4-6 Emulsion

(Manufacturing method) The raw material of the oil phase part belonging to A and the raw material of the water phase part belonging to B were heated to 70 ° C. and completely dissolved, and then the oil phase part was mixed with the aqueous phase part and emulsified with a homomixer. The emulsion was cooled to 30 ° C. to obtain an emulsion.

Formulation Examples 7-9 Moisture Cream

(Manufacturing method) The raw material of the oil phase part belonging to A and the raw material of the water phase part belonging to B were heated to 70 ° C. and completely dissolved, and then the oil phase part was mixed with the aqueous phase part and emulsified with a homomixer. The emulsion was cooled to 30 ° C. to obtain a moisture cream.

Formulation Examples 10 to 12

(Manufacturing method) The raw material of the oil phase part belonging to A and the raw material of the water phase part belonging to B are heated to 75 ° C. and dissolved, and then the aqueous phase part is mixed with the oil phase part and then stirred until 30 ° C. It cooled and the face-wash cream was obtained.

Formulation Examples 13-15 Sunscreen Cream

(Manufacturing method) The raw material of the oil phase part belonging to A and the raw material of the water phase part belonging to B were heated to 75 ° C. and completely dissolved, and then the oil phase part was mixed with the aqueous phase part and emulsified with a homomixer. The emulsion was cooled to 30 ° C. to obtain a sunscreen cream.

Formulation Examples 16-18 Liquid Foundation (Shake Well Type)

(Manufacturing method) The oil phase part which belongs to A is heated to 60 degreeC, and it cools to room temperature after that. The raw material of the oil phase part belonging to A and the raw material of the water phase part belonging to B were mixed at room temperature and emulsified with a homomixer to obtain a shake well type liquid foundation.

Formulation Examples 19-21 Shampoo

(Manufacturing method) The oil phase part which belongs to A was heated to 80 degreeC, and it cooled to room temperature after that, and obtained the shampoo.

Formulation Examples 22-24 Conditioner

(Manufacturing method) The oil phase part which belongs to A and B was heated to 80 degreeC, C heated to 80 degreeC was mixed at 80 degreeC, and it emulsified with the homomixer. The emulsion was cooled to room temperature to obtain a conditioner.

Claims (6)

An antiseptic antibacterial agent for cosmetics containing a copolymer,
The copolymer has a structural unit (a) derived from the amino group-containing monomer (A) and a structural unit (b) derived from the hydrophobic monomer (B),
The weight average molecular weight is 4000 to 200,000,
The amino group-containing monomer (A) is represented by the following formulas (4) to (6);

(In Formula (4)-(6), R < ⁶ > -R < ⁸ > is the same or different, and represents a hydrogen atom or a C1-C5 alkyl group. X represents a direct bond or a bivalent coupling group. In formulas (4) and (5), R ¹ and R ² are the same or different and represent a hydrocarbon group having 1 to 12 carbon atoms, and in formula (6), R ^{3 to} R ⁵ are the same or . differently, .Y representing a hydrocarbon group having 1 to 12 carbon atoms ^- is a structure represented by representing an anion) (where ethylene from monomer components, and the following formula;

(In the formula, R ¹¹ represents a hydrogen atom or a methyl group. R ¹² represents a hydrogen atom or an alkyl group or an alkenyl group having 1 to 22 carbon atoms. AO is the same or different and represents an oxyethylene group or an oxy group. Represents a propylene group, p represents the average number of moles added of the oxyalkylene group, and is a number of 1 to 50). A preservative antibacterial agent for cosmetics. The antiseptic antibacterial agent for cosmetics according to claim 1, wherein the hydrophobic monomer (B) has a homopolymer solubility parameter of 15 or less. The antiseptic antibacterial agent for cosmetics according to claim 1 or 2, wherein the hydrophobic monomer (B) contains at least one (meth) acrylic acid alkyl ester. In the amino group-containing monomer (A), R ⁸ in the formulas (4) to (6) is a methyl group, and X is the following formula (7);

The antiseptic antibacterial agent for cosmetics according to any one of claims 1 to 3, which has a structure represented by (wherein m represents an integer of 0 to 12). The copolymer has a structural unit (b) derived from the hydrophobic monomer (B) in a proportion of 0.01 to 90% by mass with respect to 100% by mass of the total amount of structural units forming the copolymer. The antiseptic antibacterial agent for cosmetics according to any one of claims 1 to 4, characterized by comprising: Cosmetics containing the antiseptic antibacterial agent for cosmetics in any one of Claims 1-5.