JP2017221591A - Depression medication supply device - Google Patents

Abstract

An apparatus for supplying a therapeutic drug for depression that can be miniaturized with a simple configuration and is easy to operate is provided.
A mixed gas obtained by mixing a nitrous oxide supply source, an oxygen supply source, a nitrous oxide gas supplied from the nitrous oxide supply source, and an oxygen gas supplied from the oxygen supply source. And the therapeutic agent supply unit 15 that supplies the therapeutic agent to the patient P as a therapeutic agent.
[Selection] Figure 1

Description

  The present invention relates to a depression drug supply device.

  Nitrous oxide (also called “laughing gas”) is used in medical practice as a general anesthetic (anesthetic) and sedative during surgery. Since general anesthesia using this nitrous oxide alone is difficult, volatile inhalation anesthetics (eg, sevoflurane, isoflurane, etc.) are usually used in combination.

  An anesthetic supply device (anesthetic device) for supplying an anesthetic to a patient includes a supply gas device, a vaporization pressure regulator, a gas shut-off device, an oxygen supply alarm neglect, a flow rate adjustment device, a hypoxia prevention device, and an oxygen flush device. Etc., the configuration is complicated and the size is easily increased.

  When general anesthesia is performed using this anesthesia apparatus, the supply of an anesthetic (mixture of nitrous oxide and a volatile inhalation anesthetic) to a patient is often relatively long. Further, since the use of anesthetics requires attention to side effects, general anesthesia using an anesthesia apparatus needs to be used (operated) by a skilled person such as an anesthesiologist or a surgical staff.

  By the way, nitrous oxide used as a component of an anesthetic has been reported to be effective as a therapeutic agent for patients with “treatment-resistant depression” (see Non-Patent Document 1). Specifically, Non-Patent Document 1 discloses that a mixed gas of nitrous oxide and oxygen is effective in treating depression.

Nagele P et al. Nitrous Oxide for Treatment Resistant Major Depression: a Proof of Concept Trial. Biological Psychiatry. 2015; 78: 10-8

  However, although an anesthetic device (ie, a nitrous oxide mixed gas supply device) when using nitrous oxide as an anesthetic is disclosed, a mixed gas containing nitrous oxide is used as a depression therapeutic agent for depression. The actual situation is that there is no disclosure of a drug supply device for treating depression when used for treatment.

  In addition, the anesthesia apparatus disclosed heretofore has a complicated configuration and a large size. However, a simple apparatus configuration that is easy to miniaturize is desired for a depression therapeutic drug supply apparatus used for the treatment of depression. Yes. Furthermore, conventional anesthesia devices are limited to be used by skilled personnel such as anesthesiologists and surgical staff, but the depression treatment drug supply device used for depression treatment includes medical physicians and nurses. What can be easily operated by the patient and the like is desired.

  This invention is made | formed in view of the said situation, Comprising: It aims at providing the novel therapeutic agent supply apparatus for a depression.

In order to solve the above problems, the present invention has the following configuration.
(1) A treatment for depression comprising a nitrous oxide supply source, an oxygen supply source, a nitrous oxide gas supplied from the nitrous oxide supply source, and an oxygen gas supplied from the oxygen supply source A therapeutic drug supply device comprising: a therapeutic drug supply unit that supplies a patient.
(2) It has a mixing part which mixes the nitrous oxide gas supplied from the nitrous oxide supply source and the oxygen gas supplied from the oxygen supply source, and the treatment of the depression treatment drug from the mixing part 2. The depression therapeutic drug supply device according to item 1, which is supplied to the drug supply unit.
(3) The depression therapeutic drug supply device according to item 2 above, further comprising a supply amount adjustment device that adjusts the supply amounts of nitrous oxide gas and oxygen gas to the mixing unit.
(4) The depression therapeutic drug supply device according to item 3, further comprising a control device that controls the supply amount adjusting device.
(5) The apparatus further includes a measuring device for measuring the physical findings of the patient, the control device and the measuring device are electrically connected, and the control device is configured to supply the supply amount based on the physical findings. 5. The depression therapeutic drug supply device according to 4 above, which controls the adjustment device.
(6) The depression therapeutic drug supply device according to any one of the preceding items 1 to 5, further comprising a measurement mechanism for measuring a remaining amount of nitrous oxide in the nitrous oxide supply source.

(7) The depression therapeutic drug supply device according to any one of the preceding items 1 to 6, further comprising: a housing that accommodates the configuration of the device therein, wherein at least the therapeutic drug supply unit is provided outside the housing. .
(8) The depression therapeutic drug supply apparatus according to (7), further comprising a detector that detects a concentration of at least one of nitrous oxide and oxygen in the environment outside the housing.
(9) The depression therapeutic drug supply apparatus according to any one of the preceding items 1 to 8, wherein the nitrous oxide supply source and the oxygen supply source are small cylinders having a capacity of 500 mL or less.

(10) The therapeutic agent supply device for depression according to the preceding item 1, comprising a nitrous oxide mixed gas supply source instead of the nitrous oxide supply source and the oxygen supply source.
(11) The depression remedy supply apparatus according to item 10 above, wherein the nitrous oxide mixed gas supply source is a small cylinder having a capacity of 500 mL or less.

  The depression therapeutic drug supply apparatus of the present invention has a simple configuration including a nitrous oxide supply source, an oxygen supply source, and a therapeutic drug supply unit, and can be suitably used for depression treatment.

BRIEF DESCRIPTION OF THE DRAWINGS It is a systematic diagram which shows typically the structure of the depression therapeutic drug supply apparatus which is 1st Embodiment to which this invention is applied. It is a systematic diagram which shows typically the structure of the depression therapeutic drug supply apparatus which is 2nd Embodiment to which this invention is applied. It is a systematic diagram which shows typically the structure of the depression therapeutic drug supply apparatus which is 3rd Embodiment to which this invention is applied. It is a systematic diagram which shows typically the structure of the depression therapeutic drug supply apparatus which is 4th Embodiment to which this invention is applied. It is a systematic diagram which shows typically the structure of the depression therapeutic drug supply apparatus which is 5th Embodiment to which this invention is applied.

  Hereinafter, a depression therapeutic drug supply apparatus which is an embodiment to which the present invention is applied will be described in detail. In addition, in the drawings used in the following description, in order to make the features easy to understand, there are cases where the portions that become the features are enlarged for the sake of convenience, and the dimensional ratios of the respective components are not always the same as the actual ones. Absent.

<First Embodiment>
First, the configuration of the depression treatment drug supply apparatus according to the first embodiment to which the present invention is applied will be described.
As shown in FIG. 1, the depression drug supply device 1 according to the present embodiment is a device that supplies a mixed gas of nitrous oxide and oxygen used to treat a patient P with depression. The depression treatment drug supply apparatus 1 includes a nitrous oxide cylinder (nitrous oxide supply source) 11, an oxygen cylinder (oxygen supply source) 12, a nitrogen cylinder (inert gas supply source) 13, and a pipe junction 2g. Including a piping structure (mixing part), a nitrous oxide concentration meter (nitrous oxide gas concentration measuring device) 9, an oxygen concentration meter (oxygen gas concentration measuring device) 10, a control device 7, and a treatment for depression And a therapeutic agent supply unit 15 for supplying to the patient. In this embodiment, nitrous oxide is supplied from each gas supply source as nitrous oxide gas and oxygen as oxygen gas.

  The nitrous oxide cylinder 11 used in the depression therapeutic drug supply device 1 of the present embodiment is an example of a nitrous oxide supply source, and is not particularly limited. Other nitrous oxide supply sources are adopted. Also good. Specifically, for example, a piping terminal (outlet) in a hospital facility may be used.

  Similarly, the oxygen cylinder 12 is an example of an oxygen supply source, and is not particularly limited, and other oxygen supply sources may be employed. Specifically, for example, a device that generates oxygen gas as needed may be used. In that case, a liquid gas vaporizer, a PSA gas generator, or the like may be employed. In addition, when using these apparatuses, it is preferable to select a thing with few by-product gases other than oxygen. Since the oxygen gas concentration in the air is about 21%, air pressurized with a compressor or the like may be used as the oxygen supply means.

  In addition, the depression therapeutic drug supply apparatus 1 of the present embodiment uses nitrogen gas as an inert gas, and uses a nitrogen cylinder 13 as its supply source. The nitrogen cylinder 13 is an example of an inert gas supply source, and is not particularly limited. Other liquid gas vaporizers, PSA gas generators, separation membrane gas generators, and the like may be used.

  Moreover, as an inert gas, it is not limited to nitrogen gas, For example, the structure using a carbon dioxide gas, argon, helium gas, a xenon gas, etc. may be sufficient. Further, as described above, in the case of using air pressurized by a compressor or the like as the oxygen supply source, a configuration in which the inert gas supply source is omitted may be used.

  In consideration of transport and treatment of the patient P, the depression therapeutic drug supply device 1 is desirably lightweight and movable. In this case, the nitrous oxide supply source, the oxygen supply source, and the inert gas supply source are preferably cylinders. Moreover, it is more preferable that each of these cylinders is composed of a container of 10 L or less. Furthermore, in consideration of space saving, a configuration using a two-type gas mixing cylinder or a three-type gas mixing cylinder may be used.

  The nitrous oxide cylinder 11 is provided with a gas regulator 31a and a load cell 16 as a remaining amount measuring mechanism. Thereby, the residual amount of nitrous oxide in the nitrous oxide cylinder 11 can be grasped. Similarly, by using the gas regulators 31b and 31c provided in the oxygen cylinder 12 and the nitrogen cylinder 13 as the remaining amount measuring mechanism, respectively, it is possible to appropriately grasp the remaining amounts of oxygen and nitrogen in the cylinder.

  The nitrous oxide cylinder 11, the oxygen cylinder 12, and the nitrogen cylinder 13 are provided with sterilization filters 32a, 32b, and 32c, respectively. Thereby, impurities such as dust and bacteria in the pipe can be appropriately removed.

  The nitrous oxide cylinder 11, the oxygen cylinder 12, and the nitrogen cylinder 13 are connected to pipes 2a, 2b, and 2c, which are gas supply paths, respectively. Further, the pipes 2a, 2b and 2c are connected to the pipe 2d at the pipe junction 2g, respectively. Here, although it does not specifically limit as a material of piping 2a, 2b, 2c, 2d, For example, austenitic stainless steel can be used.

  The pipes 2a, 2b, and 2c are provided with valves 3a, 3b, and 3c and check valves 4a, 4b, and 4c, respectively. In the depression therapeutic drug supply apparatus 1 of the present embodiment, the valves 3a, 3b, and 3c are each provided with an actuator that opens and closes and adjusts the opening. The actuators are electrically connected to the control device 7 respectively. Thereby, the supply_amount | feed_rate of each gas supplied from the nitrous oxide cylinder 11, the oxygen cylinder 12, and the nitrogen cylinder 13 can be adjusted suitably.

  The check valves 4a, 4b, and 4c are for preventing the back flow of gas in each pipe, and the case where the pressure of the cylinder that is a supply means of each gas is negative with respect to the pressure of the pipe 2d. In addition, it is possible to prevent the gas from flowing back from the pipe 2d side into each gas cylinder.

  The depression therapeutic drug supply device 1 of the present embodiment has a configuration including a piping structure (mixing unit) including a piping junction 2g. More specifically, in this piping structure, a pipe 2a that is a path for supplying nitrous oxide, a pipe 2b that is a path for supplying oxygen, and a pipe 2c that is a path for supplying nitrogen are combined at a pipe junction. It becomes the structure which joins in 2g and becomes the piping 2d. Thereby, each gas supplied from the nitrous oxide cylinder 11, the oxygen cylinder 12, and the nitrogen cylinder 13 passes through the pipes 2a, 2b, and 2c, and joins at the pipe junction 2g. Then, by mixing the above-mentioned gases at the pipe junction 2g, a mixed gas (that is, a therapeutic drug for depression) is generated. In addition, although it is preferable to be comprised from each piping 2a, 2b, 2c which joins so that mixed gas may become more uniform in the piping junction 2g, it is not limited to a specific structure.

  A pressure gauge 8, a nitrous oxide concentration meter 9, an oxygen concentration meter 10, and a flow meter 21 are arranged in this order from the piping junction 2 g side to the piping 2 d that is a supply path for the depression therapeutic drug from the piping junction 2 g to the patient P. A valve 3d is provided. In addition, a therapeutic agent supply unit 15 that supplies a therapeutic agent for depression to the patient P is provided at the tip of the pipe 2d.

  A discharge pipe 2m is branched from between the flow meter 21 and the valve 3d in the pipe 2d. The discharge pipe 2m is provided with a valve 3m. The material of the discharge pipe 2m is not particularly limited, but is preferably lightweight and high-strength. Specific examples include austenitic stainless steel.

  The valve 3m includes an actuator that opens and closes and adjusts the opening degree. The actuator is electrically connected to the control device 7.

  For example, after the use of the depression therapeutic drug supply apparatus 1 of the present embodiment is started (that is, when supply of each gas from the nitrous oxide cylinder 11, the oxygen cylinder 12, and the nitrogen cylinder 13 is started), the valve 3d is closed and the valve 3m is closed. By opening the gas, the gas remaining in the pipe 2d is expelled, and the mixed gas outside the target concentration range is exhausted while the nitrous oxide gas concentration and the oxygen gas concentration are adjusted.

  Thereafter, when the nitrous oxide concentration and the oxygen gas concentration in the mixed gas measured by the nitrous oxide concentration meter 9 and the oxygen concentration meter 10 reach the respective target concentration ranges, the valve 3d is opened and the valve 3m is opened. By closing, administration of the therapeutic agent (depression therapeutic agent) to the patient P is started.

  As a result, an accurate mixed gas of nitrous oxide gas concentration and oxygen gas concentration after the concentration of nitrous oxide and oxygen is stabilized can be administered to the patient P as a treatment for depression.

  When the gas is discharged from the discharge pipe 2m, the valve 3d is closed, the valve 3m is opened, the gas is allowed to flow through the pipe 2a and the pipe 2d, and the valve 3m is closed again. Then, the valve 3m is opened and the gas is discharged. By repeating this operation (purge by batch) 2 to 3 times and flowing gas intermittently, purging of the pipe 2a and the pipe 2d can be completed earlier than in the case of continuously flowing gas. .

  Further, the valve 3d is closed, the valve 3m is opened, a gas is allowed to flow through the pipe 2b and the pipe 2d, and the valve 3m is closed again. Then, the valve 3m is opened and the gas is discharged. By repeating this operation (purge by batch) 2 to 3 times and flowing gas intermittently, purging of the pipe 2b and the pipe 2d can be completed earlier than in the case of flowing gas continuously. .

  Similarly, the valve 3d is closed, the valve 3m is opened, a gas is allowed to flow through the pipe 2c and the pipe 2d, and the valve 3m is closed again. Then, the valve 3m is opened and the gas is discharged. By repeating this operation (purge for batches) 2 to 3 times and intermittently flowing gas, purging of the pipe 2c and the pipe 2d can be completed earlier than in the case of continuously flowing gas. .

  The branching position of the discharge pipe 2m from the pipe 2d is not particularly limited as long as it is downstream (secondary side) with respect to the pipe structure (mixing part) including the pipe junction 2g, but the concentration of each gas is accurately determined. It is preferable to be the latter stage (secondary side) of the nitrous oxide concentration meter 9 and the oxygen concentration meter 10 that can be measured. In addition, since the pipe 2d can be purged to a position as close as possible to the patient P by setting the latter stage (secondary side) of the flow meter 21, it is possible to administer the depression treatment drug with an accurate concentration to the patient P.

  The therapeutic drug supply unit 15 includes a pipe 2d which is a supply pipe for a mixed gas (depression drug), and a mask or patient attached to the tip of the pipe 2d so as to cover the mouth and nose of the patient P A tube that plugs directly into the mouth, nose and throat of P. In the case of a tube, those having an inner diameter of 5 mm and a length of about 5 m are preferable.

  In the depression therapeutic drug supply apparatus 1 of the present embodiment, nitrous oxide is supplied as nitrous oxide gas, and oxygen is supplied as oxygen gas. The nitrous oxide concentration meter 9 and the oxygen concentration meter 10 measure gas concentrations in a mixed gas containing nitrous oxide gas and oxygen gas, respectively.

  The nitrous oxide concentration meter 9 is not particularly limited as long as it can measure the concentration of nitrous oxide gas. Specifically, for example, a densitometer that performs analysis by a non-dispersive infrared absorption method, a nitrous oxide gas concentration meter by a mid-infrared DFG-TDLAS method, or the like can be used.

  The oxygen concentration meter 10 is not particularly limited as long as it can measure the concentration of oxygen gas. Specifically, for example, a diaphragm galvanic cell type oxygen gas concentration meter can be used.

  In the piping 2d that is a supply path from the piping structure (mixing unit) including the piping confluence 2g to the patient P, the mixed gas that is a therapeutic agent for depression is uniformly mixed in the subsequent stage (secondary side) of the piping confluence 2g. It is preferable. Specifically, for example, the deviation of the concentration distribution of each component in the mixed gas is preferably 5.0% or less. In this case, the sub-oxidation measured by the nitrous oxide concentration meter 9 and the oxygen concentration meter 10 is performed. The nitrogen gas concentration and the oxygen gas concentration can take accurate values. For the purpose of making the concentration distribution of the mixed gas uniform, a static mixer, a mixer, a mixing tank, or the like may be provided as a gas mixing unit at the subsequent stage (secondary side) of the pipe confluence 2g.

  The valve 3d is provided with an actuator capable of adjusting the opening degree. Further, the valve 3d and the flow meter 21 are electrically connected to the control device 7, and the actuator of the valve 3d is controlled by the control device 7 according to the flow rate value measured by the flow meter 21, so that the flowing mixed gas flows. The flow rate can be adjusted. That is, the pressure and flow rate of the mixed gas (depression treatment drug) supplied to the patient P can be controlled.

  Here, by using a flowmeter 21 having an integrating function, it becomes possible to monitor the cumulative dose of the therapeutic agent for depression to the patient P. Further, by using a device having an atmospheric pressure correction function using a barometer or the like and a temperature correction function using a temperature sensor, it is possible to improve the accuracy of the flow control of the mixed gas (depressive medicine). .

  Not only the flow meter 21 and the valve 3d, but also the pressure gauge 8, the nitrous oxide concentration meter 9, and the oxygen concentration meter 10 are electrically connected to the control device 7, respectively, and send each actual measurement value as a signal to the control device 7, It is the structure which adjusts the density | concentration of each component of the mixed gas (depression treatment drug) supplied to the patient P.

  The control device 7 controls the nitrous oxide gas concentration, the oxygen gas concentration, the flow rate and pressure of the mixed gas in the mixed gas supplied to the patient P (depression treatment drug). The control device 7 is electrically connected to a measurement device (examination device) (not shown) that measures the physical findings PV of the patient, and the condition of the patient P is based on the measurement results of the physical findings PV of the patient. The optimum nitrous oxide gas concentration, oxygen gas concentration, pressure and flow rate of the mixed gas (depressive medicine) are determined.

  The concentration of the nitrous oxide gas in the mixed gas (depression treatment drug) to be administered to the patient P is controlled to be 50 vol% or less, which is a value that does not cause hypoxia. Moreover, although a minimum is not specifically limited, From a viewpoint of obtaining the administration effect of the therapeutic agent for depression in the patient P, it is preferable to set it as 0.1 volume% or more. In particular, it is preferable to control the nitrous oxide gas concentration to be 1.0 to 50% by volume in accordance with the condition of the patient P. Moreover, it is preferable to control the density | concentration of the oxygen gas administered to the patient P so that it may become 21-70 volume% vicinity according to the patient's P condition, especially the value of arterial blood oxygen partial pressure, and a saturation degree.

  The control device 7 controls the valves 3a, 3b, and 3c based on the measurement values obtained by the nitrous oxide concentration meter 9 and the oximeter 10 provided in the pipe 2d that is a supply path to the patient P, and nitrous oxide. The gas supply amount, the oxygen gas supply amount, and the nitrogen gas supply amount are adjusted. Thereby, the mixed gas (depression treatment drug) having the above-mentioned optimum nitrous oxide gas concentration and oxygen gas concentration is created.

  Further, the control device 7 adjusts the opening degree of the valve 3d based on the measured value of the flow rate of the mixed gas by the flow meter 21 and supplies the patient P with the optimal mixed gas flow rate.

  Further, the control device 7 controls the opening and closing of the valve 3d and the valve 3m based on the measurement values obtained by the nitrous oxide concentration meter 9 and the oxygen concentration meter 10, and the mixing having optimum nitrous oxide gas concentration and oxygen gas concentration is performed. When the gas is generated, the mixed gas is administered to the patient P as a treatment for depression.

  The physical findings PV of patient P include arterial oxygen partial pressure and saturation, arterial blood carbon dioxide partial pressure and saturation, minute ventilation, heart rate, electrocardiogram, blood pressure, blood glucose level, urine output, pH, body temperature. And biochemical test values. Among these, any 1 type (s) or 2 or more types are measured. The examination item to be measured is preferably determined according to the disease or injuries such as various organ disorders of the target patient P. For example, while measuring arterial blood oxygen partial pressure and saturation, arterial blood carbon dioxide partial pressure and saturation, and minute ventilation, which are closely related to a mixed gas (depression treatment) administered to patient P, patient P It is desirable to determine the concentration of nitrous oxide gas and oxygen gas in the mixed gas (depressive drug) to be administered to the patient.

The minute ventilation is a ventilation for one minute due to the breathing of the patient P, and the following equation (A) is established.
Minute ventilation = tidal volume x number of ventilations per minute ... (A)
Examples of the biochemical test value include a troponin T value detected at the time of myocardial infarction.

  The control device 7 includes, as an operation control system, a controller that drives each drive unit and a control unit that controls each controller. Each controller is composed of, for example, a PID controller, etc., and is electrically connected to an actuator provided in the valves 3a, 3b, 3c, 3d, 3m, a mixed gas supply means 15 to the patient, etc.・ Stop and adjust.

  As described above, the control device 7 measures the physical value PV of the patient P and the nitrous oxide gas concentration and oxygen gas concentration in the current mixed gas (depression treatment), and based on these results. Then, according to the control program recorded inside, the nitrous oxide gas concentration and the oxygen gas concentration in the mixed gas (depression treatment) to be administered to the patient P are optimized, and each parameter (nitrous oxide gas flow rate value, oxygen A control signal for changing the input value of the gas flow rate value and the nitrogen gas flow rate value is output to the controller. Each controller starts, stops, and adjusts each drive unit according to a control signal from the control unit, and nitrous oxide gas concentration and oxygen gas concentration in a mixed gas (depression treatment) to be administered to the patient P Operation control for optimizing the operation is performed continuously.

  As explained above, according to the depression therapeutic drug supply device 1 of the present embodiment, the nitrous oxide concentration meter 9 for measuring the nitrous oxide gas concentration and the oxygen gas concentration in the mixed gas (depression therapeutic drug) and The oxygen concentration meter 10 and a control device 7 for controlling the nitrous oxide gas concentration and the oxygen gas concentration in the mixed gas to arbitrary values based on these measured values are provided. Therefore, it is possible to appropriately change the amounts of nitrous oxide and oxygen in this mixed gas (depressive drug). That is, it becomes possible to administer a therapeutic agent for depression appropriately adjusted for nitrous oxide and oxygen as needed according to the physical findings PV of the patient P.

  Moreover, according to the depression therapeutic drug supply apparatus 1 of this embodiment, it has the structure provided with the piping structure containing 2 g of piping junctions as a mixing part. That is, a mixed gas can be generated simply by passing each gas. Accordingly, it is possible to generate a mixed gas (depression treatment drug) without having a complicated structure, and the depression treatment drug supply apparatus 1 can have a simple structure.

  Moreover, according to the depression therapeutic drug supply apparatus 1 of this embodiment, it has the residual amount measurement mechanism of nitrous oxide and oxygen. As a result, gas exhaustion can be prevented and gas can be supplied safely.

<Second Embodiment>
Next, the configuration of the depression treatment drug supply apparatus according to the second embodiment to which the present invention is applied will be described. FIG. 2 is a system diagram schematically showing the configuration of the depression therapeutic drug supply apparatus according to the second embodiment of the present invention. Note that the same components as those in the first embodiment described above are denoted by the same reference numerals and description thereof is omitted.

  As shown in FIG. 2, the depression therapeutic drug supply apparatus 20 of the present embodiment is provided with mass flow controllers (MFC) 5a, 5b, and 5c in pipes 2a, 2b, and 2c, which are supply paths for the respective gases, and pipes. The configuration differs from the depression therapeutic drug supply device 1 of the first embodiment described above in that a mixing tank (mixing unit) 6 is provided instead of the junction 2g.

  That is, in the depression therapeutic drug supply device 20 of the present embodiment, the pipes 2a, 2b, and 2c, which are the supply paths of the gases supplied from the nitrous oxide cylinder 11, the oxygen cylinder 12, and the nitrogen cylinder 13, are all mixing tanks. 6 is connected. Then, the mixed gas uniformly stirred in the mixing tank 6 is supplied to the patient P as a treatment for depression via the pipe 2d. Hereinafter, different configurations will be described in detail.

  As shown in FIG. 2, the pipes 2a, 2b and 2c are provided with valves 3a, 3b and 3c, mass flow controllers (MFC) 5a, 5b and 5c, and check valves 4a, 4b and 4c, respectively. In the present embodiment, the valves 3a, 3b, 3c only open and close, and do not adjust the opening.

  The MFCs 5a, 5b, and 5c are flow rate control devices having a measurement unit that measures the flow rate value of the fluid and a valve unit that can adjust the opening degree by an actuator using a solenoid or a piezo. I have control. Moreover, MFC5a, 5b, 5c is electrically connected with the control apparatus 7, and can control the pressure and flow volume of each gas. Use of the MFCs 5a, 5b, and 5c having an atmospheric pressure correction function using a barometer or the like and a temperature correction function using a temperature sensor is preferable because it is possible to improve the flow rate control accuracy of the mixed gas.

  The check valves 4a, 4b and 4c prevent backflow of each gas, and even when the pressure of the cylinder which is a supply means of each gas becomes negative with respect to the pressure of the mixing tank 6. Further, it is possible to prevent the gas from flowing back from the mixing tank 6 side into the gas cylinders.

  The mixing tank 6 is a mixing part of nitrous oxide gas, oxygen gas, and nitrogen gas, and has a structure or a structure for uniformly mixing each gas therein. As the structure or structure, a static mixer that is a line mixer without a drive unit, a mixer having a drive unit, or a combination of these can be used.

  The mixing tank 6 also serves as a mixed gas storage means for storing the mixed gas. When the mixing tank 6 is not used as the mixed gas storage means, a tank container or the like may be separately provided as each gas storage section.

  The material of the mixing tank 6 is not particularly limited, but is preferably made of a material having high gas tightness, light weight and high strength. Specific examples include austenitic stainless steel.

  The tank volume of the mixing tank 6 can be determined in consideration of the amount of gas supplied to the patient P and the time required to equalize the gas concentration in the tank. When it is necessary to supply a plurality of patients P from the mixing tank 6 simultaneously, a large-capacity mixing tank 6 is required. However, for the purpose of use when the patient P is transported, it is important to reduce the weight of the apparatus. In some cases, a small capacity mixing tank 6 may be used. Also, two tanks may be connected in series, one for concentration adjustment and the other for storage, ie for supply to the patient P. The number of tanks may be increased as necessary.

  The mixing tank 6 is provided with a pressure gauge 8, a nitrous oxide concentration meter 9, and an oxygen concentration meter 10. The pressure gauge 8, the nitrous oxide concentration meter 9, and the oxygen concentration meter 10 are each electrically connected to the control device 7, and each measured value is sent to the control device 7 as a signal to supply the mixed gas to the patient P. The concentration, pressure, and flow rate of each component are adjusted.

  Since the mixing tank 6 is provided with a structure or structure for uniformly mixing the mixed gas as described above, the mixed gas in the mixing tank 6 can be made uniform. For example, the mixing tank 6 can be made uniform so that the deviation of the concentration distribution of each component in the mixed gas in the tank is 5.0% or less.

  The control device 7 determines the nitrous oxide gas concentration and the oxygen gas concentration of the mixed gas (depressive medicine) in the mixing tank 6 based on the measured values by the nitrous oxide concentration meter 9 and the oxygen concentration meter 10, 3b and 3c and MFCs 5a, 5b and 5c are controlled to adjust the nitrous oxide gas flow rate, the oxygen gas flow rate and the nitrogen gas flow rate, respectively. Thereby, a mixed gas having the above-mentioned optimum nitrous oxide gas concentration and oxygen gas concentration is produced. In addition, the control device 7 adjusts the opening degree of the valve 3d based on the measured value of the mixed gas flow rate by the flow meter 21, and supplies the patient P with a mixed gas flow rate that is optimal for the patient P.

  As described above, according to the depression therapeutic drug supply apparatus 20 of the present embodiment, in the mixed gas in accordance with the physical findings PV of the patient P, similarly to the depression therapeutic drug supply apparatus 1 of the first embodiment. The nitrous oxide and oxygen can be adjusted as needed and appropriately administered to the patient P as a treatment for depression.

  Moreover, according to the depression therapeutic drug supply device 20 of the present embodiment, the nitrous oxide concentration meter 9 and the oxygen concentration meter 10 that measure the nitrous oxide gas concentration and the oxygen gas concentration in the mixed gas include the nitrous oxide and It is provided in a mixing tank 6 that uniformly contains a mixed gas containing oxygen. Thus, the concentration of the mixed gas having a uniform concentration distribution can be measured by the nitrous oxide concentration meter 9 and the oxygen concentration meter 10. That is, the nitrous oxide gas concentration and the oxygen gas concentration in the mixed gas can be accurately measured, and the mixed gas having the optimum component ratio for the patient P can be supplied as a treatment for depression.

<Third Embodiment>
Next, the configuration of the depression therapeutic drug supply apparatus according to the third embodiment to which the present invention is applied will be described. FIG. 3 is a system diagram schematically showing a configuration of a depression therapeutic drug supply apparatus according to the third embodiment of the present invention. In addition, about the component same as the above-mentioned 1st and 2nd embodiment, the same code | symbol is attached | subjected and the description is abbreviate | omitted.

  Here, the depression therapeutic drug supply devices 1 and 20 of the first and second embodiments described above supply a mixed gas (depression therapeutic drug) to the patient P having spontaneous breathing. On the other hand, the depression therapeutic drug supply apparatus according to the third embodiment is used for a patient P who needs to assist spontaneous breathing even if the patient P is not spontaneously breathing or is a patient P having spontaneous breathing. A gas mixture of nitrous oxide and oxygen is supplied as a treatment for depression. That is, as shown in FIG. 3, the depression therapeutic drug supply device 30 of the present embodiment has been described above in that it includes a ventilator 18 as a therapeutic drug supply unit that supplies a depression therapeutic drug to the patient P. The configuration differs from the depression therapeutic drug supply devices 1 and 20 of the first and second embodiments.

  As shown in FIG. 3, in the depression therapeutic drug supply device 30 of the present embodiment, the gases supplied from the nitrous oxide cylinder 11, the oxygen cylinder 12, and the nitrogen cylinder 13 are respectively connected via pipes 2 a, 2 b, and 2 c. And supplied to the mixer (mixing unit) 14. The mixed gas uniformly stirred in the mixer 14 is supplied to the mixing tank (mixing unit, storage unit) 6 through the pipe 2e, and further supplied from the mixing tank 6 to the ventilator 18 through the pipe 2d. Supplied and administered to patient P as a treatment for depression.

  The mixing tank 6 is provided with a pressure gauge 8, a nitrous oxide concentration meter 9a, and an oxygen concentration meter 10. Further, the pressure gauge 8, the nitrous oxide concentration meter 9a, and the oxygen concentration meter 10 are electrically connected to the control device 7, respectively. Thereby, each measured value measured by the pressure gauge 8, the nitrous oxide concentration meter 9a, and the oxygen concentration meter 10 is sent to the control device 7 as an electrical signal. Then, based on these measured values, the control device 7 can appropriately adjust the concentration, pressure, and flow rate of each component in the mixed gas supplied to the ventilator 18.

  The mixed gas stored in the mixing tank 6 needs to be adjusted in pressure and flow rate according to the specifications of the ventilator 18. Therefore, the control device 7 performs control so that the mixed gas that meets the specifications of the ventilator 18 is stored in the mixing tank 6.

  The ventilator 18 is connected to a pipe 2d that is a supply path of a mixed gas from the mixing tank 6 and an oxygen line 22 that is a hospital-side facility. Thereby, after the mixed gas from the pipe 2d and the oxygen from the oxygen line 22 are further mixed inside the ventilator 18, a new mixed gas is supplied to the patient P as a treatment for depression. Become. Instead of the oxygen line 22 of the hospital facility, an oxygen cylinder may be connected.

  The ventilator 18 has measuring means for measuring the flow rate, pressure, and oxygen gas concentration therein. Further, the ventilator 18 is electrically connected to the control device 7, and signals various measurement results from measuring means for measuring the flow rate, pressure, and oxygen gas concentration provided therein to the control device 7. As sent.

  The air supply path 23 from the ventilator 18 to the patient P is provided with a nitrous oxide concentration meter 9b. Further, the nitrous oxide concentration meter 9 b is electrically connected to the control device 7. Thereby, the actual measurement value of the nitrous oxide gas concentration in the air supply path 23 to the patient P measured by the nitrous oxide concentration meter 9b is sent to the control device 7 as an electric signal. And based on the various measurement results in the ventilator 18 and the measurement results of the nitrous oxide gas concentration in the nitrous oxide concentration meter 9b, the control device 7 determines the components in the new mixed gas supplied to the patient P. The concentration can be adjusted as appropriate.

  In addition, when the ventilator 18 does not have an external output capable of being electrically connected to the control device 7, in addition to the nitrous oxide concentration meter 9 b, pressure is supplied to the air supply path 23 from the ventilator 18 to the patient. The pressure, concentration, and flow rate of the mixed gas supplied from the ventilator 18 to the patient P can be controlled by providing a meter, an oximeter, and a flow meter and electrically connecting them to the control device 7. it can.

  The ventilator 18 can adjust the supply amount of the mixed gas supplied to the patient P, and is preferably adjusted to 10 L / min or less, for example. The ventilator 18 has an exhaust path 24 from the patient in addition to an air supply path 23 to the patient. That is, the patient P inhales a new mixed gas supplied from the air supply path 23 to the patient. On the other hand, the exhaust from the patient P is exhausted to the exhaust path 24. The exhaust path 24 is opened to the atmosphere by the ventilator 18. Further, the exhaust path 24 may be connected to an exhaust gas processing device (not shown).

  The ventilator 18 can select various operation modes. As an operation mode, for example, an intermittent positive pressure ventilation mode in which artificial ventilation is performed at regular intervals for a patient P who does not have spontaneous breathing, and artificial ventilation is performed irregularly triggered by inspiration of the patient P having spontaneous breathing. There are an intermittent forced breathing mode, a mode in which air is injected under pressure when the respiratory device senses the inspiratory effort of the patient P, and the like. Utilizing these operation modes, the mixed gas is supplied to the patient P as a treatment for depression.

  As described above, according to the depression medicine supply device 30 of the third embodiment, since the configuration includes the ventilator 18, the patient P having no spontaneous breathing and the patient P having spontaneous breathing are provided. Even if it exists, the mixed gas of the optimal nitrous oxide gas density | concentration and oxygen gas density | concentration can be administered to the patient P who needs the ventilator 18 for the purpose of assisting as a depression therapeutic agent.

<Fourth Embodiment>
Next, the configuration of the depression therapeutic drug supply apparatus according to the fourth embodiment to which the present invention is applied will be described. FIG. 4 is a system diagram schematically showing a configuration of a depression therapeutic drug supply apparatus according to a fourth embodiment to which the present invention is applied.

  As shown in FIG. 4, the depression therapeutic drug supply apparatus 40 of the present embodiment includes a high-pressure oxygen gas source (oxygen supply source) 101, a high-pressure nitrous oxide gas source (nitrous oxide supply source) 102, and oxygen gas. Supply pipe L1, nitrous oxide gas supply pipe L2, therapeutic drug supply pipe L3, therapeutic drug supply hose L4, therapeutic drug supply unit 116, purge pipe (exhaust pipe) L5, and decompression pipe (decompression line) ) L6, a casing 117, and a control device 114, and is schematically configured.

  Moreover, the depression therapeutic drug supply apparatus 40 of this embodiment is the high-pressure oxygen gas source 101, the high-pressure nitrous oxide gas source 102, the oxygen gas supply pipe L1, the nitrous oxide gas supply pipe L2, the treatment among the above-described configurations. The medicine supply pipe L3, a part of the purge pipe L5, and the control device 14 are housed inside the casing 117, and the therapeutic drug supply section 116 is arranged outside the casing 117.

  The high-pressure oxygen gas source 101 is connected to one end of the oxygen gas supply pipe L1. Thereby, oxygen gas can be supplied from the high-pressure oxygen gas source 101 into the oxygen gas supply pipe L1. Specifically, as the high-pressure oxygen gas source 101, for example, an oxygen gas cylinder made of a known material such as FRP (Fiber Reinforced Plastics), steel, or aluminum can be used.

  Further, when an oxygen gas cylinder is used as the high-pressure oxygen gas source 101, the internal volume is not particularly limited, but for example, a small cylinder having a capacity of 500 mL or less is preferably used. By using a small cylinder of 500 mL or less, the entire apparatus can be reduced in size. More specifically, the high-pressure oxygen gas source 101 is more preferably a small cylinder such as FRP.

  The high-pressure nitrous oxide gas source 102 is connected to one end of the nitrous oxide gas supply pipe L2. Thus, nitrous oxide gas can be supplied from the high-pressure nitrous oxide gas source 102 into the nitrous oxide gas supply pipe L2. Specifically, as the high-pressure nitrous oxide gas source 102, for example, a nitrous oxide gas cylinder made of a known material such as FRP, steel, or aluminum can be used.

  Further, when a nitrous oxide gas cylinder is used as the high-pressure nitrous oxide gas source 102, the internal volume is not particularly limited, but for example, a small cylinder of 500 mL or less is preferably used. By using a small cylinder having a capacity of 500 mL or less, the entire apparatus can be downsized.

  The other end of the oxygen gas supply pipe L1 is connected to, for example, a nitrous oxide gas supply pipe L2 and a therapeutic drug supply pipe L3 via a three-way valve, a joint, and the like. Thereby, oxygen gas can be supplied to the therapeutic agent supply pipe L3 via the oxygen gas supply pipe L1.

  An oxygen pressure sensor 103 is provided in the oxygen gas supply pipe L1. The pressure of the gas in the oxygen gas supply pipe L1 can be measured by the oxygen pressure sensor 103. The oxygen pressure sensor 103 is electrically connected to the control device 114 via a signal line. The pressure value measured by the oxygen pressure sensor 103 is transmitted to the control device 114 via a signal line.

  The oxygen gas supply pipe L1 is provided with an oxygen flow meter 105 on the secondary side of the oxygen pressure sensor 103. The flow rate of gas in the oxygen gas supply pipe L1 can be controlled and measured by the oxygen flow meter 105. Here, the oxygen flow meter 105 is not particularly limited. Specifically, for example, a mass flow controller, an integrated flow meter, or the like can be used. The oxygen flow meter 105 is electrically connected to the control device 114 via a signal line. The flow rate value measured by the oxygen flow meter 105 is transmitted to the control device 114 via a signal line.

  The oxygen gas supply pipe L1 is provided with an oxygen sterilization filter 107 on the secondary side of the oxygen flow meter 105. The oxygen sterilization filter 107 can sterilize the oxygen gas flowing through the oxygen gas supply pipe L1.

  The oxygen gas supply pipe L1 is provided with an oxygen supply valve 109 on the secondary side of the sterilization filter 107 for oxygen. By controlling the opening and closing of the oxygen supply valve 109, the amount of oxygen gas supplied from the oxygen gas supply pipe L1 to the therapeutic drug supply pipe L3 can be controlled. The oxygen supply valve 109 is electrically connected to the control device 114 via a signal line. The controller 114 can control the opening and closing of the oxygen supply valve 109 via the signal line.

  The other end of the nitrous oxide gas supply pipe L2 is connected to the oxygen gas supply pipe L1 and the therapeutic drug supply pipe L3 via, for example, a three-way valve, a joint, or the like. Thereby, nitrous oxide gas can be supplied to the therapeutic agent supply pipe L3 via the nitrous oxide gas supply pipe L2.

  A nitrous oxide pressure sensor 104 is provided in the nitrous oxide gas supply pipe L2. The pressure of the gas in the nitrous oxide gas supply pipe L2 can be measured by the nitrous oxide pressure sensor 104. The nitrous oxide pressure sensor 104 is electrically connected to the control device 114 via a signal line. The pressure value measured by the nitrous oxide pressure sensor 104 is transmitted to the control device 114 via a signal line.

  The nitrous oxide gas supply pipe L2 is provided with a nitrous oxide flow meter 106 on the secondary side of the nitrous oxide pressure sensor 104. The flow rate of the gas in the nitrous oxide gas supply pipe L2 can be controlled and measured by the nitrous oxide flow meter 106. Here, the nitrous oxide flow meter 106 is not particularly limited, but specifically, for example, a mass flow controller, an integrated flow meter, or the like can be used. The nitrous oxide flow meter 106 is electrically connected to the control device 114 via a signal line. The flow value measured by the nitrous oxide flow meter 106 is transmitted to the control device 114 via a signal line.

  The nitrous oxide gas supply pipe L2 is provided with a nitrous oxide sterilization filter 108 on the secondary side of the nitrous oxide flow meter 106. The nitrous oxide sterilization filter 108 can sterilize the nitrous oxide gas flowing through the nitrous oxide gas supply pipe L2.

  The nitrous oxide gas supply pipe L2 is provided with a nitrous oxide supply valve 110 on the secondary side of the nitrous oxide sterilization filter 108. By controlling the opening and closing of the nitrous oxide supply valve 110, the amount of nitrous oxide gas supplied from the nitrous oxide gas supply pipe L2 to the therapeutic agent supply pipe L3 can be controlled. The nitrous oxide supply valve 110 is electrically connected to the control device 114 via a signal line. The controller 114 can control the opening and closing of the nitrous oxide supply valve 110 via the signal line.

  In the depression therapeutic drug supply device 40 of the present embodiment, the oxygen supply valve 109 and the nitrous oxide supply valve 110 described above can be used as switching means (supply amount adjusting device). Specifically, the nitrous oxide gas in the mixed gas (depression treatment drug) supplied into the therapeutic drug supply pipe L3 is controlled by controlling the opening degrees of the oxygen supply valve 109 and the nitrous oxide supply valve 110, respectively. The concentration and the oxygen gas concentration can be adjusted as appropriate. Also, by closing the nitrous oxide supply valve 110, oxygen gas can be supplied into the therapeutic agent supply pipe L3. That is, by controlling the switching means (supply amount adjusting device), the oxygen gas or the mixed gas (therapeutic agent) to be supplied into the therapeutic agent supply pipe L3 can be appropriately selected.

  More specifically, oxygen gas or a mixed gas of oxygen and nitrous oxide (therapeutic agent) can be easily selected and supplied as the gas to be supplied to the therapeutic agent supply unit 116. In addition, when the patient's condition such as hypoxia and vomiting deteriorates during the treatment, oxygen gas can be supplied and immediate treatment is possible.

  The therapeutic drug supply pipe L3 has one end connected to the oxygen gas supply pipe L1 and the nitrous oxide gas supply pipe L2, and the other end connected to the therapeutic drug supply hose L4 via a joint 115 provided in the housing 117. Yes.

  A therapeutic agent supply valve 112 is provided in the therapeutic agent supply pipe L3. By controlling the opening / closing degree of the therapeutic drug supply valve 112, the supply amount of the mixed gas (therapeutic drug) from the therapeutic drug supply pipe L3 to the therapeutic drug supply hose L4 can be controlled. The therapeutic agent supply valve 112 is electrically connected to the control device 114 via a signal line. The controller 114 can control the degree of opening and closing of the therapeutic drug supply valve 112 via a signal line.

  In addition, a gas mixing part (mixing part) 118 is provided on the primary side of the therapeutic drug supply valve 112 in the therapeutic drug supply pipe L3. The gas mixing unit 118 is not particularly limited as long as it can promote gas mixing (uniformity). Specifically, for example, it is preferable to apply a static mixer, a mixer, a mixing tank, or the like.

  One end of the therapeutic agent supply hose L4 is connected to the therapeutic agent supply pipe L3 via the joint 115, and the other end is connected to the therapeutic agent supply unit 116. The mixed gas (therapeutic agent) supplied from the therapeutic agent supply pipe L3 can be supplied to the therapeutic agent supply unit 116 by the therapeutic agent supply hose L4.

  The therapeutic agent supply unit 116 is not particularly limited as long as it can supply the mixed gas supplied from the therapeutic agent supply hose L4 to the patient. For example, an inhalation mask can be used.

  One end of the purge pipe L5 is connected to the therapeutic drug supply pipe L3 on the primary side of the therapeutic drug supply valve 116, and the other end is provided so that a purge pump and an exhaust gas treatment device (not shown) can be connected. . The purge pipe L5 can purge the gas remaining inside the oxygen gas supply pipe L1, the nitrous oxide gas supply pipe L2, and the therapeutic agent supply pipe L3. As a result, gas (for example, air), dust, etc. other than the gas used for treatment mixed in the apparatus when the high-pressure oxygen gas source 101 and the high-pressure nitrous oxide gas source 102 are replaced are transferred to the affected part via the therapeutic agent supply unit 116. It can be prevented from being supplied.

  A purge valve 111 is provided in the purge pipe L5. By controlling the opening and closing of the purge valve 111, the purge of the gas in the pipe can be controlled. The purge valve 111 is electrically connected to the control device 114 through a signal line. The controller 114 can control the opening and closing of the purge valve 111 via a signal line.

  The decompression pipe L6 has one end connected to the therapeutic agent supply hose L4 and the other end open to the outside. A pressure reducing valve 113 is provided in the pressure reducing pipe L6. The pressure in the therapeutic agent supply unit 116 can be appropriately adjusted by exhausting the gas in the therapeutic agent supply unit 116 to the outside via the decompression pipe L6 as necessary by the pressure reducing valve 113. Thereby, the pressure and flow rate of the gas supplied to the therapeutic agent supply unit 116 can be adjusted appropriately. The pressure reducing valve 113 is electrically connected to the control device 114 through a signal line. The controller 114 can control the opening / closing of the pressure reducing valve 113 via the signal line.

  Inside the housing 117 (inside), a high pressure oxygen gas source 101, a high pressure nitrous oxide gas source 102, and the like are provided. The depression therapeutic drug supply apparatus 40 according to the present embodiment can be freely carried and moved by providing the high-pressure oxygen gas source 101, the high-pressure nitrous oxide gas source 102, and the like in the housing 117. In addition, since it is not necessary to prepare a gas source separately, the gas source can be used not only in a medical facility equipped with medical gas pipes and the like but also in, for example, a general household or a care facility.

  On the side surface of the housing 117, an oxygen gas detector 119, which is a means for detecting the oxygen concentration, is provided so that the detection portion is located outside the housing 117. With the oxygen gas detector 119, the oxygen concentration in the atmosphere outside the housing 117 can be measured. The oxygen gas detector 119 is electrically connected to the control device 114 via a signal line. The value of the oxygen concentration measured by the oxygen gas detector 119 is transmitted to the control device 114 via a signal line.

  Further, a nitrous oxide gas detector 120 that is a means for detecting the nitrous oxide concentration is provided on the side surface of the casing 117 so that the detection portion is located outside the casing 117. The nitrous oxide gas detector 120 can measure the nitrous oxide concentration in the atmosphere outside the housing 117. Further, the nitrous oxide gas detector 120 is electrically connected to the control device 114 via a signal line. The value of the nitrous oxide concentration measured by the nitrous oxide gas detector 120 is transmitted to the control device 114 via a signal line.

  The control device 114 includes an oxygen pressure sensor 103, an oxygen flow meter 105, an oxygen supply valve 109, a nitrous oxide pressure sensor 104, a nitrous oxide flow meter 106, and a nitrous oxide supply valve 110 via signal lines. The therapeutic agent supply valve 112, the purge valve 111, the pressure reducing valve 113, the oxygen gas detector 119, and the nitrous oxide gas detector 120 are electrically connected to each other.

  By controlling the open / closed state of the oxygen supply valve 109, the nitrous oxide supply valve 110, the therapeutic agent supply valve 112, and the purge valve 111 by the control device 114, the nitrous oxide gas concentration, oxygen gas concentration, and mixed gas in the mixed gas are controlled. It is possible to control switching between oxygen gas and gas supply and purging by a method such as sequence control.

  Further, the control device 114 controls the pressure reducing valve 113 based on the pressure value measured by the pressure sensors 103 and 104 and the flow value measured by the flowmeters 105 and 106, so that the therapeutic drug supply unit 116 is controlled. The pressure and flow rate of the supplied mixed gas (therapeutic agent) can be appropriately adjusted.

  Further, when the control device 114 detects that the pressure value measured by the pressure sensors 103 and 104 and the flow value measured by the flowmeters 105 and 106 are out of the setting range, an alarm or the like is issued. Also good. Thereby, it is possible to notify the user of gas leakage, cylinder replacement time, and maintenance time.

  When the control device 114 detects that the oxygen concentration measured by the oxygen gas detector 119 or the nitrous oxide concentration measured by the nitrous oxide gas detector 120 exceeds a set value, the oxygen supply valve 109, By automatically closing the nitrous oxide supply valve 110 and the therapeutic agent supply valve 112 as necessary, it is possible to prevent the environment around the apparatus from becoming an oxygen-deficient state or an oxygen-enriched state.

  Next, a usage method (operation method) of the depression therapeutic drug supply apparatus 40 of the present embodiment will be described in detail with reference to FIG. Specifically, a case will be described as an example in which depression treatment is performed using the above-described depression therapeutic drug supply apparatus 40, and then switching to oxygen gas is performed to suppress hypoxia, nausea / vomiting, and the like.

  In addition, in the depression therapeutic drug supply apparatus 40 before use, the oxygen supply valve 109, the nitrous oxide supply valve 110, the therapeutic drug supply valve 112, the purge valve 111, and the pressure reducing valve 113 are all closed.

  When starting depression treatment (after replacement of the nitrous oxide supply source and the oxygen supply source), first, the oxygen supply valve 109, the nitrous oxide supply valve 110, and the purge valve 111 are opened by the control device 114, so that oxygen The gas remaining inside the gas supply pipe L1, the nitrous oxide gas supply pipe L2, and the therapeutic agent supply pipe L3 is purged. Thereby, it can suppress that gas other than the mixed gas of oxygen and nitrous oxide is supplied to the therapeutic agent supply part 116. FIG. After sufficiently purging the gas, the purge valve 111 is returned to the closed state.

  Next, by opening the therapeutic drug supply valve 112 by the control device 114, a mixed gas of oxygen and nitrous oxide is supplied from the high pressure oxygen gas source 101 and the high pressure nitrous oxide gas source 102 to the therapeutic drug supply unit 116. Supply. During the supply of the mixed gas of oxygen and nitrous oxide, the control device 114 controls the pressure reducing valve 113 based on the pressure value measured by the pressure sensors 103 and 104 and the flow value measured by the flow meters 105 and 106. Thus, the pressure and flow rate of the mixed gas of oxygen and nitrous oxide supplied to the therapeutic agent supply unit 116 are appropriately adjusted. As a result, depression treatment can be performed by supplying a mixed gas of oxygen and nitrous oxide by the therapeutic agent supply unit 116.

  Next, when the depression treatment is completed, the control device 114 returns the nitrous oxide supply valve 110 to the closed state, thereby supplying the nitrous oxide gas from the high-pressure nitrous oxide gas source 102 to the therapeutic agent supply unit 116. Stop. Thereby, only oxygen gas can be supplied, and it becomes possible to suppress hypoxia, nausea, vomiting, and the like.

  As described above, according to the depression therapeutic drug supply device 40 of the present embodiment, since it has a simple configuration including at least the nitrous oxide supply source, the oxygen supply source, and the therapeutic drug supply unit 116, the entire apparatus is provided. Can be miniaturized. In addition, unlike anesthetics, volatile inhalation anesthetics are not used, and nitrous oxide gas and volatile inhalation anesthetics do not need to be mixed by specialists. Mixing of nitrous oxide gas and oxygen gas Operation is easy because gas is used as a therapeutic agent.

  Further, according to the depression therapeutic drug supply apparatus 40 of the present embodiment, the entire apparatus is further downsized by using a small cylinder or the like having a capacity of 500 mL or less as the high-pressure oxygen gas source 101 and the high-pressure nitrous oxide gas source 102. can do.

  Further, according to the depression therapeutic drug supply apparatus 40 of the present embodiment, by providing the high-pressure oxygen gas source 101, the high-pressure nitrous oxide gas source 102, and the like in the housing 117, it can be freely carried or moved. . In addition, since it is not necessary to prepare a gas source separately, the gas source can be used not only in a medical facility equipped with medical gas pipes and the like but also in, for example, a general household or a care facility.

  Further, in the depression therapeutic drug supply device 40 of the present embodiment, an open / close valve is provided in the supply path of nitrous oxide gas and oxygen gas to form a switching means (supply amount adjusting device), and the opening degree is controlled to treat each. The nitrous oxide gas concentration and oxygen gas concentration in the mixed gas (depression treatment drug) supplied to the drug supply unit 116 can be adjusted as appropriate. Further, by closing the nitrous oxide supply valve 110, oxygen gas can be supplied to the therapeutic agent supply unit 116. That is, oxygen gas or a mixed gas (therapeutic drug) can be appropriately selected as a gas to be supplied to the therapeutic drug supply unit 116 by controlling the switching means (supply amount adjusting device). Therefore, it is possible to select and supply a therapeutic agent or oxygen gas according to the patient's condition.

<Fifth Embodiment>
Next, the configuration of the depression therapeutic drug supply apparatus according to the fifth embodiment to which the present invention is applied will be described. FIG. 5 is a system diagram schematically showing a configuration of a depression therapeutic drug supply apparatus according to a fifth embodiment to which the present invention is applied.

  As shown in FIG. 5, the depression therapeutic drug supply apparatus 50 according to the present embodiment includes a high-pressure mixing in which oxygen gas and nitrous oxide gas are mixed instead of the high-pressure oxygen gas source 101 and the high-pressure nitrous oxide gas source 102. The configuration differs from the depression therapeutic drug supply device 40 of the fourth embodiment described above in that it includes a gas source (nitrous oxide mixed gas supply source) 121 and a mixed gas pressure sensor 122.

  According to the depression therapeutic drug supply device 50 of the present embodiment, a mixed gas cylinder is used as the high-pressure mixed gas source 121, and a mixed gas of oxygen gas and nitrous oxide is supplied to the patient as a depression therapeutic drug. Thus, further downsizing and weight reduction of the apparatus can be achieved.

  The technical scope of the present invention is not limited to the above embodiment, and various modifications can be made without departing from the spirit of the present invention. For example, in the above-described depression therapeutic drug supply apparatus 40 of the fourth embodiment, the configuration using the gas supplied from the high-pressure oxygen gas source 101 and the high-pressure nitrous oxide gas source 102 has been described as an example. It is not limited.

  For example, at least one of the oxygen gas supply pipe L1 and the nitrous oxide gas supply pipe L2 further includes a supply pipe for supplying another gas from a supply source provided outside the depression treatment drug supply apparatus 40. Also good. Thereby, not only the gas source in the apparatus but also a gas source outside the apparatus can be arbitrarily selected.

  Moreover, in the depression therapeutic agent supply apparatus 40 mentioned above, it is good also as a structure which provides a weight meter (for example, load cell etc.) in the high pressure nitrous oxide gas source 102. Thereby, the residual amount of nitrous oxide can be accurately grasped. Further, the weight scale may be electrically connected to the control device 114 via a signal line. Further, when the control device 114 detects that the measurement value transmitted from the weighing scale is out of the set range, an alarm or the like may be issued. Thereby, it is possible to notify the user of gas leakage, cylinder replacement time, and maintenance time.

  In the above-described depression therapeutic drug supply apparatus 40, the configuration having the high-pressure oxygen gas source 101 and the high-pressure nitrous oxide gas source 102 in the housing 117 has been described as an example, but the present invention is not limited to this. For example, either one or both of the high-pressure oxygen gas source 101 and the high-pressure nitrous oxide gas source 102 may be provided outside the housing 117.

  In the above-described depression therapeutic drug supply apparatus 40, the configuration in which the oxygen gas detector 119 and the nitrous oxide gas detector 120 are provided on the side surface of the casing 117 is described as an example, but the present invention is not limited thereto. Instead, you may install in arbitrary places. For example, the oxygen gas detector 119 and the nitrous oxide gas detector 120 may be provided in the therapeutic agent supply unit 116 or in the vicinity thereof. As a result, the oxygen concentration and nitrous oxide concentration around the patient can be detected, which is more effective in preventing oxygen deficiency and oxygen enrichment.

  Moreover, in the above-described depression therapeutic drug supply apparatus 40, the therapeutic drug supply unit 116 may include a device for humidifying gas as necessary.

  Moreover, in the above-mentioned depression therapeutic drug supply apparatus 40, you may provide a ventilator as needed.

  Further, in the above-described depression therapeutic drug supply apparatus 40, the oxygen gas supply pipe L1 and the nitrous oxide gas supply pipe L2 have a check valve for preventing a back flow of gas and a pressure reduction for reducing the pressure in the pipe. A valve may be provided.

  Moreover, in the depression therapeutic drug supply apparatus 40 described above, the casing 117 may include a caster for moving the apparatus to the bottom or side surface of the casing.

1, 20, 30, 40, 50... Depression therapeutic agent supply device 2 a, 2 b, 2 c, 2 d, 2 e, piping 2 g, piping junction (mixing unit)
2m ... Pipe for discharge 3a, 3b, 3c, 3d, 3m ... Valve 4a, 4b, 4c, 4d ... Check valve 5a, 5b, 5c ... Mass flow controller (MFC)
6 ... Mixing tank (mixing section, storage section)
7 ... Control device 8 ... Pressure gauge (pressure measuring device)
9, 9a, 9b ... Nitrous oxide concentration meter (nitrous oxide gas concentration measuring device)
10. Oxygen concentration meter (oxygen gas concentration measuring device)
11 ... Nitrous oxide cylinder (Nitrous oxide supply source)
12 ... Oxygen cylinder (oxygen supply source)
13 ... Nitrogen cylinder (inert gas supply source)
14 ... Mixer (mixing part)
15 ... therapeutic agent supply unit 16 ... load cell 18 ... ventilator (therapeutic agent supply unit)
DESCRIPTION OF SYMBOLS 21 ... Flow meter 22 ... Oxygen line 23 ... Air supply path 24 to a patient ... Exhaust path 31a, 31b, 31c from a patient ... Gas regulator 32a, 32b, 32c ... Sterilization filter P ... Patient,
PV ... Physical findings 101 ... High pressure oxygen gas source (oxygen supply source)
102 ... High-pressure nitrous oxide gas source (nitrous oxide supply source)
DESCRIPTION OF SYMBOLS 103 ... Oxygen pressure sensor 104 ... Nitrous oxide pressure sensor 105 ... Oxygen flow meter 106 ... Nitrous oxide flow meter 107 ... Oxygen sterilization filter 108 ... Nitrous oxide sterilization filter 109 ... Oxygen supply valve 110 ... Sub Nitrogen oxide supply valve 111 ... purge valve 112 ... therapeutic agent supply valve 113 ... pressure reducing valve 114 ... control device 115 ... joint 115 ... therapeutic agent supply unit 117 ... casing 118 ... gas mixing unit (mixing unit)
119 ... Oxygen gas detector (detector)
120 ... Nitrous oxide gas detector (detector)
121 ... High pressure mixed gas source (nitrous oxide mixed gas supply source)
122 ... Pressure sensor for mixed gas

Claims (11)

A nitrous oxide source,
An oxygen source;
Depression comprising: a remedy supply unit that supplies a patient with a treatment for depression prepared by mixing nitrous oxide gas supplied from the nitrous oxide supply source and oxygen gas supplied from the oxygen supply source. Therapeutic drug supply device. A mixing unit for mixing nitrous oxide gas supplied from the nitrous oxide supply source and oxygen gas supplied from the oxygen supply source;
The depression therapeutic drug supply device according to claim 1, wherein the depression therapeutic drug is supplied from the mixing unit to the therapeutic drug supply unit.   The depression therapeutic drug supply device according to claim 2, comprising a supply amount adjusting device for adjusting a supply amount of nitrous oxide gas and oxygen gas to the mixing unit.   The depression therapeutic drug supply device according to claim 3, further comprising a control device that controls the supply amount adjusting device. Further comprising a measuring device for measuring the physical findings of the patient,
The control device and the measuring device are electrically connected,
The depression control drug supply device according to claim 4, wherein the control device controls the supply amount adjustment device based on the physical findings.   The depression therapeutic drug supply apparatus according to any one of claims 1 to 5, further comprising a measurement mechanism that measures a remaining amount of nitrous oxide in the nitrous oxide supply source. A housing that houses the configuration of the device inside,
The depression therapeutic drug supply device according to any one of claims 1 to 6, wherein at least the therapeutic drug supply unit is provided outside the casing.   The depression therapeutic drug supply device according to claim 7, further comprising a detector that detects a concentration of at least one of nitrous oxide and oxygen in an environment outside the housing.   The depression therapeutic drug supply apparatus according to any one of claims 1 to 8, wherein the nitrous oxide supply source and the oxygen supply source are small cylinders having a capacity of 500 mL or less.   The depression therapeutic drug supply device according to claim 1, further comprising a nitrous oxide mixed gas supply source instead of the nitrous oxide supply source and the oxygen supply source.   The depression therapeutic drug supply device according to claim 10, wherein the nitrous oxide mixed gas supply source is a small cylinder having a capacity of 500 mL or less.

Images