JP2016214467A - Blood purification system - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a blood purification system capable of efficiently utilizing a discrete value of biology grain counting means.SOLUTION: A blood purification system comprises: plural monitoring devices 1 to which, a blood purification tool for performing blood purification treatment to a patient, is attached respectively; and dialysate supply means 2 capable of supplying a predetermined liquid, such as a dialysate, dialysate liquid concentrate, hot water, washing liquid or antiseptic solution to the respective monitoring devices 1, in which, a predetermined step on the plural monitoring devices 1 is performed based on a predetermined preset step signal. The blood purification system further comprises biology grain counting means 3 for counting at real time, biology grains contained in the predetermined liquid supplied to the monitoring devices 1, a predetermined operation is performed based on the discrete value of the biology grain counting means 3, and the predetermined operation is determined according to the step signal.SELECTED DRAWING: Figure 1

Description

  The present invention relates to a blood purification system in which a predetermined process in a plurality of blood purification means is performed based on a predetermined process signal set in advance.

  In general, a blood purification system has a dialysate supply device installed in a machine room at a medical site such as a hospital, and a dialysis monitoring device installed in a dialysis room (treatment room), which is a separate place. The dialysate supply device and the monitoring device for dialysis are connected by a pipe. The dialysis fluid supply device is a device that supplies purified water to produce a predetermined concentration of dialysis fluid, while the dialysis monitoring device corresponds to the number of blood purifiers (dialyzers) for dialysis treatment for patients. A plurality of dialysate prepared by a dialysate supply device are introduced through a pipe and supplied to a blood purifier.

  That is, the dialysis fluid supply device installed in the machine room is distributed to a plurality of dialysis monitoring devices installed in the dialysis chamber, and the dialysis fluid is sent, and the dialysis fluid is supplied to the dialyzer in each. It is. In addition, the dialysis fluid supply device and each dialysis monitoring device are electrically connected, and the dialysis fluid supply device (supply means) is used for each dialysis during the dialysis treatment process, the piping cleaning process, or the disinfection process. A device that transmits an electrical signal (process signal) to a monitoring device (blood purification means) has been proposed (see, for example, Patent Document 1). Thus, when each dialysis monitoring device receives a predetermined electrical signal (process signal), an operation (such as driving a pump or opening / closing a solenoid valve) according to the signal is performed.

  By the way, the dialysis fluid supplied from the dialysis fluid supply device to each dialysis monitoring device requires high cleanliness, and conventionally, a biological particle counting means capable of counting biological particles contained in the dialysis fluid in real time. The thing which has arrange | positioned to the dialysis apparatus is proposed. According to the biological particle counting means, the cleanliness of the dialysis fluid can be accurately grasped during dialysis treatment, compared to an offline type in which a predetermined amount of dialysis fluid is collected and the biological particles are cultured.

JP 2004-16412 A JP 2013-144057 A

  However, in the above conventional blood purification system, although the cleanliness of the dialysate can be grasped in real time, some operation is performed in the dialysate supply device or each dialysis monitoring device based on the count value by the biological particle counting means. It is not done. Therefore, there is a problem that the count value of the bioparticles obtained in real time by the bioparticle counting means cannot be effectively used. Therefore, the applicant of the present invention causes the dialysate supply device or each dialysis monitoring device to perform a predetermined operation based on the count value obtained by the biological particle counting means, and calculates the biological particles obtained in real time by the biological particle measuring means. We came to intensively study how to make effective use of numerical values.

  This invention is made | formed in view of such a situation, and it is providing the blood purification system which can utilize effectively the count value by a biological-particles counting means.

  The invention according to claim 1 is a plurality of blood purification means to which a blood purification device for performing blood purification treatment on a patient is attached, and each of the blood purification means has a dialysis solution, dialysate stock solution, hot water, washing solution or disinfecting solution. In a blood purification system in which predetermined steps in the plurality of blood purification means are performed based on a predetermined process signal set in advance. A biological particle counting unit capable of counting in real time the biological particles contained in the predetermined liquid to be supplied; a predetermined operation is performed based on a count value by the biological particle counting unit; The operation is determined according to the process signal.

  According to a second aspect of the present invention, in the blood purification system according to the first aspect, the step performed based on the step signal includes a treatment step for performing blood purification treatment by the blood purification means, and a flow for circulating the predetermined liquid. In addition to having a cleaning / disinfecting step for cleaning or disinfecting the path, the predetermined operation is an operation based on a count value by the biological particle counting means corresponding to the treatment step or the cleaning / disinfecting step.

  According to a third aspect of the present invention, in the blood purification system according to the first or second aspect, the predetermined operation is performed based on a count value obtained by the biological particle counting unit during the treatment step. The cleanliness of the predetermined liquid supplied to the blood is notified, or the blood purification treatment by the blood purification means is continued or stopped, and at the time of the cleaning / disinfecting step, the count value by the biological particle counting means is obtained. The operation is based on monitoring the effect of cleaning or disinfection or notifying the cleanliness of the flow path through which the predetermined liquid flows.

  According to a fourth aspect of the present invention, in the blood purification system according to the third aspect, in the cleaning and disinfecting step, the cleaning or disinfecting is additionally performed based on a count value by the biological particle counting means. To do.

  According to a fifth aspect of the present invention, in the blood purification system according to any one of the second to fourth aspects, the flow of introducing the predetermined liquid from the flow path through which the predetermined liquid is circulated to the biological particle counting means. And the cleaning and disinfecting step includes a disinfecting step of circulating hot water or a disinfecting liquid through a flow path through which the predetermined liquid is distributed, and at the time of the disinfecting step, It is characterized in that the introduction can be limited.

  The invention according to claim 6 is the blood purification system according to any one of claims 1 to 5, further comprising a cleaning filter for cleaning the predetermined liquid supplied to the blood purification means, The biological particle counting means is capable of counting biological particles of the predetermined liquid flowing at least downstream of the cleaning filter, and evaluates the cleaning effect of the cleaning filter according to the process signal. It is characterized by obtaining.

  According to a seventh aspect of the present invention, in the blood purification system according to the sixth aspect, the biological particle counting means counts and compares the predetermined liquid biological particles flowing upstream and downstream of the cleaning filter. The cleaning effect of the cleaning filter can be evaluated according to the process signal.

  According to the first aspect of the present invention, the biological particle counting means capable of counting in real time the biological particles contained in the predetermined liquid supplied to the blood purification means is provided, and based on the count value by the biological particle counting means. Since the predetermined operation is performed and the predetermined operation is determined according to the process signal, the count value by the biological particle counting means can be effectively used.

  According to the invention of claim 2, the process performed based on the process signal includes a treatment process for performing blood purification treatment by the blood purification means, and a cleaning / disinfecting process for cleaning or disinfecting the flow path through which the predetermined liquid flows. The predetermined operation is an operation based on the count value by the biological particle counting means corresponding to the treatment step or the cleaning / disinfecting step. A predetermined operation can be performed.

  According to the invention of claim 3, during the treatment step, the predetermined operation reports the cleanliness of the predetermined liquid supplied to the blood purification means based on the count value by the biological particle counting means, or the blood purification means In the cleaning / disinfecting process, the effect of cleaning or disinfecting is monitored based on the count value of the biological particle counting means, or the flow path for circulating a predetermined liquid is used. Since the operation is to notify the cleanliness, a more appropriate predetermined operation according to the treatment process and the cleaning / disinfecting process can be performed based on the count value by the biological particle counting means.

  According to the fourth aspect of the present invention, in the cleaning / disinfecting step, cleaning or disinfection is additionally performed based on the count value by the biological particle counting means, so that cleaning or disinfection can be performed more reliably.

  According to the fifth aspect of the present invention, there is provided an introduction flow path for introducing the predetermined liquid from the flow path for circulating the predetermined liquid to the biological particle counting means, and the cleaning / disinfecting step is performed by adding hot water to the flow path for circulating the predetermined liquid. Alternatively, it has a disinfection step for circulating a disinfectant solution, and at the time of the disinfection step, introduction of hot water or disinfectant solution through the introduction channel can be restricted, so that the biological particle measuring means is damaged by the hot water or disinfectant solution. Can be prevented.

  According to the invention of claim 6, the biological particle counting means includes the predetermined liquid flowing in at least the downstream side of the cleaning filter, the cleaning filter cleaning the predetermined liquid supplied to the blood purification means. The biological particles can be counted, and the cleaning effect of the cleaning filter can be evaluated according to the process signal. Therefore, the performance and life of the cleaning filter can be accurately grasped.

  According to the invention of claim 7, the biological particle counting means can count and compare biological particles of a predetermined liquid flowing on the upstream side and the downstream side of the cleaning filter, respectively, and according to the process signal, Since the cleaning effect of the cleaning filter can be evaluated, the performance and life of the cleaning filter can be accurately grasped in real time.

1 is an overall schematic diagram showing a blood purification system according to an embodiment of the present invention. Schematic diagram showing the configuration of the monitoring device (blood purification means) in the blood purification system Flow chart showing control contents (control during treatment process) in the blood purification system The flowchart which shows the control content (control at the time of a cleaning disinfection process and a treatment process) in the blood purification system Flow chart showing control contents (control during cleaning / disinfecting process) in the blood purification system Overall schematic view showing a blood purification system according to a second embodiment of the present invention. Overall schematic view showing a blood purification system according to another embodiment of the present invention. Overall schematic view showing a blood purification system according to still another embodiment of the present invention.

Hereinafter, embodiments of the present invention will be specifically described with reference to the drawings.
The blood purification system according to the first embodiment is for supplying a dialysis solution having a predetermined concentration to a plurality of monitoring apparatuses for dialysis. As shown in FIG. ) And a plurality of monitoring devices 1 (corresponding to the “blood purification means” of the present invention) and a dialysate supply device 2 (this book) installed in a machine room that is different from the dialysis room in the medical field. Corresponding to “supplying means” of the invention.

  The monitoring device 1 (blood purification means) is equipped with a dialyzer 8 (blood purification device) (see FIG. 2) for performing blood purification treatment (hemodialysis treatment) on a patient, and dialyzed from the dialysate supply device 2 A plurality of liquids are supplied to the dialyzer 8 and installed in the dialysis chamber. The monitoring device 1 is provided with a touch panel 1a capable of giving instructions and predetermined display of hemodialysis treatment and other control contents (washing or disinfection).

  More specifically, in each of the plurality of monitoring devices 1, as shown in FIG. 2, a pipe L1 extending from the dialysate supply apparatus 2 is drawn and a pipe L2 connected to a drain means (not shown). And the dual pump 10 is arranged across the pipes L1 and L2. Among these, the pipe L1 in the monitoring device 1 includes a flow rate detection sensor 11 that detects the flow rate of the liquid flowing through the pipe L1, a hydraulic pressure detection sensor 12 that detects the supply pressure of the liquid, and the electrical conductivity of the liquid ( A conductivity detection sensor 13 for detecting (concentration) is provided.

  Further, a dialysate introduction line L4 communicated with the pipe L1 and a dialysate discharge line L5 communicated with the pipe L2 are extended from the duplex pump 10, and the distal end of the dialysate introduction line L4 via the coupler C is extended. Can be connected to the dialysate inlet 8a of the dialyzer 8, and the tip of the dialysate discharge line L5 can be connected to the dialysate outlet 8b of the dialyzer 8 via the coupler C. As described above, each monitor device 1 is provided with a dialyzer 8 corresponding to a patient, and the dialyzer 8 is connected to a blood circuit 9 for circulating the patient's blood extracorporeally. .

  The pump chamber of the duplex pump 10 is divided by a single plunger (not shown) into a liquid supply side pump chamber connected to the pipe L1 and a discharge side pump chamber connected to the pipe L2. By reciprocating, the dialysate or the washing solution sent to the liquid feeding side pump chamber is supplied to the dialyzer 8 and the dialysate in the dialyzer 8 is sucked into the discharge side pump chamber. Furthermore, a pipe L3 that connects the pipe L2 and the dialysate discharge line L5 while bypassing the duplex pump 10 is formed in the monitoring device 1, and a water removal pump 14 is disposed in the middle of the pipe L3. ing. By driving the water removal pump 14, it is possible to perform water removal on the blood of the patient flowing in the dialyzer 8.

  Instead of the dual pump 10, a so-called chamber type may be used, and sensors such as the flow rate detection sensor 11, the hydraulic pressure detection sensor 12, or the conductivity detection sensor 13 may be optionally provided. You may make it add well or another general purpose thing. Furthermore, in the present embodiment, the sensors are arranged in the pipe L1, but may be arranged in another pipe (for example, the pipe L2).

  The dialysate supply device 2 (supply means) can prepare dialysate having a predetermined concentration using clean water and dialysate stock solution and can supply the prepared dialysate to each of the monitoring devices 1 (blood purification means). Is. That is, the dialysate supply device 2 is connected to each of the plurality of monitoring devices 1 via the pipe L1, and each of the monitoring devices 1 is connected to the monitoring device 1 via the pipe L1, such as dialysate, hot water, washing liquid, or disinfecting liquid. It is configured to be able to supply a predetermined liquid. In addition, the dialysate supply device 2 is provided with a touch panel 2a capable of giving an instruction and a predetermined display of control contents related to dialysate supply, cleaning, or disinfection.

  On the other hand, the plurality of monitoring devices 1 is a step for operating a predetermined process (pump driving, electromagnetic stool opening / closing, etc.) based on a predetermined process signal transmitted from the dialysate supply device 2, A replacement step of replacing the inside of the pipe with dialysate, a blood purification treatment step, a cleaning / disinfecting step, or the like) is performed. Thereby, each monitoring apparatus 1 will perform a predetermined process uniformly and simultaneously according to a predetermined process signal.

  In the blood purification system according to the present embodiment, the dialysate supply device 2 (supply means) and each monitoring device 1 (blood purification means) are connected by a LAN (local area network: local communication network). Bidirectional information communication is possible. Thereby, in this blood purification system, predetermined information can be transmitted from the dialysate supply device 2 to the plurality of monitoring devices 1, and the predetermined information is maintained while maintaining the predetermined operation based on the above-described process signal. The plurality of monitoring devices 1 can be controlled based on the above.

  That is, the dialysate supply device 2 and each monitoring device 1 are LAN-connected via a LAN cable α, and the dialysate supply device 2 is connected to the monitoring device 1 via the LAN cable α. While the interface unit 4 and the control unit 5 for communicating between each other are disposed, the monitoring unit 1 has an interface unit 6 for communicating with the dialysate supply device 2 via the LAN cable α and A control unit 7 (see FIG. 2) is arranged. Further, a dialysis communication system T is connected to the LAN cable α, and communication between the monitoring device 1 and the dialysate supply device 2 is controlled. Such a LAN is not limited to the one using the LAN cable α (wired) as in the present embodiment, but may be one that can communicate bidirectional information wirelessly (wireless LAN).

  In the dialysate supply device 2, a predetermined operation (preparation of dialysate, etc.) is performed by the control unit 5, and a process signal can be transmitted to the monitoring device 1 through the interface unit 4. . Further, in the monitoring device 1, when the interface unit 6 receives a process signal from the dialysate supply device 2, operations based on the process signal (priming before treatment, hemodialysis treatment, blood return, washing / disinfection, etc.) are performed. The control is performed by the control unit 7.

  Here, in this embodiment, the biological particle counting means 3 is connected to the upstream side of all the monitoring devices 1 in the pipe L1. The biological particle counting means 3 is connected to the pipe L1 through the introduction flow path L1a, and is supplied with a predetermined liquid (dialysis liquid, hot water, washing liquid or disinfecting liquid before being supplied to the monitoring apparatus 1 while flowing through the pipe L1. Etc.), and biological particles (microparticles derived from living organisms) contained in the guided predetermined liquid can be counted in real time.

  More specifically, the biological particle counting means 3 according to the present embodiment irradiates the liquid introduced from the introduction flow path L1a with a laser beam having a specific wavelength, and detects the scattered light and autofluorescence. And an autofluorescence counting unit 3b that counts the autofluorescence number based on the signal output from the light detection unit 3a, and the autofluorescence number is the bioparticle count (of the bioparticle counting means 3). Counted). In addition, autofluorescence is light emitted from substances (riboflavin, NAD (P) H (nicotinamide adenine dinucleotide (phosphate), etc.) necessary for metabolism existing in biological particles (intracellular) (laser light is biological). Light that is absorbed by the particles and emitted using the energy).

  The biological particle counting means 3 is electrically connected to the interface unit 4 of the dialysate supply device 2 via the wiring β, and the count value (number of biological particles) can be transmitted to the dialysate supply device 2. It is said that. In this embodiment, a predetermined operation (operation by the dialysate supply device 2, operation by the monitoring device 1, and other devices constituting the blood purification system based on the received count value by the biological particle counting means 3 is used. The predetermined operation is determined according to the process signal.

  Specifically, the process performed based on the process signal includes a treatment process for performing blood purification treatment by the monitoring device 1, and a cleaning / disinfecting process for cleaning or disinfecting a flow path (introduction flow path L1a) for circulating a predetermined liquid. In addition, the predetermined operation is an operation based on the count value by the biological particle counting means 3 corresponding to the treatment process or the cleaning / disinfecting process. For example, in the predetermined operation, during the treatment process, based on the count value by the biological particle counting means 3, the degree of cleanliness of the predetermined liquid supplied to the monitoring device 1 is notified or the blood purification treatment by the monitoring device 1 is continued. Alternatively, in the cleaning and disinfecting process, the cleaning or disinfecting effect is monitored or the flow path (pipe L1) through which a predetermined liquid is circulated is determined based on the count value by the biological particle counting means 3 during the cleaning and disinfecting process. The operation is to notify the degree.

  Furthermore, in the present embodiment, at the time of the cleaning / disinfecting step, cleaning or disinfection may be additionally performed based on the count value by the biological particle counting means 3. In addition, in the present embodiment, there is an introduction flow path L1a that guides the predetermined liquid from the flow path (pipe L1) for circulating the predetermined liquid to the biological particle counting means 3, and the cleaning and disinfecting step There is a disinfection step for circulating hot water or a disinfectant solution in the flow passage (pipe L1), and at the time of the disinfection step, for example, the introduction flow passage L1a is provided by a valve (not shown) or the like disposed in the introduction flow passage L1a. The introduction of hot water or disinfectant by the can be limited. The restriction in this case includes a mode in which when the disinfection process is started, the valve disposed in the introduction flow path L1a is closed to shut off the flow path, and if necessary, the introduction flow path In order to cause L1a to be disinfected, a disinfectant may be introduced from time to time. The disinfection time can also be shortened to protect the equipment constituting the biological particle counting means 3.

Next, the control contents in the blood purification system according to the present embodiment will be described based on the flowcharts of FIGS.
First, the control contents in the treatment process will be described based on the flowchart of FIG. When a process signal for performing a treatment process is transmitted from the dialysate supply device 2 to each monitoring device 1 in S1, the biological particle counting means 3 counts the biological particles in S2. Then, in S3, it is determined whether or not the count value by the biological particle counting means 3 is smaller than a predetermined threshold value a. Make it.

  If it is determined in S3 that the count value is not smaller than the threshold value a, the process proceeds to S5, where it is determined whether the count value is smaller than a predetermined threshold value b (where a <b). If it is determined that the value is smaller, the process proceeds to S6 and a predetermined notification is given, and then the process proceeds to S4 to continue the treatment. The notification performed in S6 is performed with an indication that there are many biological particles and the degree of cleanliness is deteriorated. For example, when the operator performs the next cleaning / disinfecting, the time is extended to increase the effect of the cleaning / disinfecting. , It is possible to perform treatment as required. On the other hand, if it is determined in S5 that the count value is not smaller than the threshold value b, the process proceeds to S7, and after a predetermined alarm is given that can grasp that the cleanliness is extremely poor, the treatment is continued by the operator in S8. It is determined whether or not to perform. If it is determined in S8 that the operator continues the treatment, the process proceeds to S4 to continue the treatment. If it is determined not to continue the treatment, the process proceeds to S9 and the treatment is stopped.

  Next, the control contents in the cleaning / disinfecting process will be described based on the flowchart of FIG. In S1, when a process signal for performing the cleaning / disinfecting process is transmitted from the dialysate supply device 2 to each monitoring device 1, counting of the biological particles by the biological particle counting means 3 is stopped in S2, In S3, operations necessary for cleaning and disinfection (circulation of cleaning liquid and disinfecting liquid, etc.) are performed. When the cleaning / disinfecting process is completed and a process signal for performing the treatment process is transmitted from the dialysate supply device 2 to each monitoring device 1 in S4, the operation (dialysis solution necessary for treatment) is performed in S5. Etc.).

  Thereafter, in S6, the biological particle counting means 3 counts the biological particles, and in S7, whether or not the counted value is smaller than a preset threshold A (a value set as a normal range from a trend associated with the course of treatment). If the count value is smaller than the threshold value A, the process proceeds to S8 to continue the treatment. Further, when it is determined in S7 that the count value is not smaller than the threshold value A, the process proceeds to S9, where it is determined whether or not the count value is smaller than a preset threshold value B (a value that is considered to affect the treatment). When it is determined that the count value is smaller than the threshold value B, the process proceeds to S10, a predetermined notification is performed, and then the process proceeds to S8 to continue the treatment.

  The notification performed in S10 is performed with an indication that there are a lot of biological particles and the cleanliness is deteriorated. For example, when the operator performs the next cleaning and disinfection, the time is extended to increase the effect of the cleaning and disinfection. , It is possible to perform treatment as required. On the other hand, if it is determined in S9 that the count value is not smaller than the threshold value B, the process proceeds to S11, and after a predetermined alarm is given that can grasp that the cleanliness is extremely poor, the treatment is continued by the operator in S12. It is determined whether or not to perform. If it is determined in S12 that the operator continues the treatment, the process proceeds to S8 and the treatment is continued. If it is determined that the treatment is not continued, the process proceeds to S13 and the treatment is stopped.

  Next, other control contents in the cleaning / disinfecting step will be described based on the flowchart of FIG. In S1, when a process signal for performing the cleaning / disinfecting process is transmitted from the dialysate supply device 2 to each monitoring device 1, counting of the biological particles by the biological particle counting means 3 is stopped in S2, In S3, an operation necessary for disinfection (distribution of disinfectant solution, etc.) is performed. When the disinfection operation is completed and the cleaning operation is started in S4, the biological particles are counted by the biological particle counting means 3 in S5.

  Then, in S6, it is determined whether or not the count value by the biological particle counting means 3 is smaller than a predetermined threshold A ′, and the count value is based on the threshold A ′ (a value set as a normal range from a trend associated with the course of treatment). When it determines with it being small, it progresses to S7 and supplies dialysate. When it is determined in S6 that the count value is not smaller than the threshold value A ′, the process proceeds to S8, where it is determined whether or not the count value is smaller than the threshold value B ′ (a value that is considered to affect the treatment). When it is determined that the numerical value is smaller than the threshold value B ′, the process proceeds to S9 to perform a predetermined notification, and then proceeds to S7 to supply the dialysate.

  The notification performed in S9 is performed with an indication that there are many biological particles and the cleanliness is deteriorated. For example, when the operator performs the next cleaning and disinfecting, the time is extended to increase the effect of the cleaning and disinfecting. , It is possible to perform treatment as required. On the other hand, if it is determined in S8 that the count value is not smaller than the threshold value B ', the process proceeds to S10, and after a predetermined alarm is given that can grasp that the cleanliness is extremely poor, it is added by the operator in S11. It is determined whether or not to perform disinfection and cleaning.

  If it is determined in S11 that the operator performs additional disinfection and cleaning, the process returns to S2, and a series of operations are performed again, and when the operator determines that no additional disinfection and cleaning is performed, Proceeding to S12, it is determined whether or not the operator may supply the dialysate. Thereafter, when it is determined in S12 that the operator can supply the dialysate, it is determined in S7 that the dialysate is supplied and the operator does not supply the dialysate. Then, the process proceeds to S13 and the supply of dialysate is stopped.

  According to the embodiment, the biological particle counting means 3 that can count the biological particles contained in the predetermined liquid supplied to the monitoring device 1 in real time is provided, and based on the count value by the biological particle counting means 3. Since the predetermined operation is performed and the predetermined operation is determined according to the process signal, the count value obtained by the biological particle counting means 3 can be used effectively. Moreover, the process performed based on the process signal which concerns on this embodiment has the treatment process which performs the blood purification treatment by the monitoring apparatus 1, the washing | cleaning disinfection process which wash | cleans or disinfects the flow path which distribute | circulates a predetermined | prescribed liquid, Since the operation is based on the count value by the biological particle counting means 3 corresponding to the treatment process or the cleaning / disinfecting process, the operation according to the treatment process and the cleaning / disinfecting process is based on the count value by the biological particle counting means 3. A predetermined operation can be performed.

  Further, the predetermined operation according to the present embodiment is performed by notifying the cleanliness of the predetermined liquid supplied to the monitoring device 1 based on the count value by the biological particle counting means 3 or by the blood purification means in the treatment process. The operation of continuing or stopping the blood purification treatment is performed, and at the time of the cleaning / disinfecting process, the effect of the cleaning / disinfecting is monitored based on the count value by the biological particle counting means 3, or the flow path for circulating a predetermined liquid is used. Since it is set as the operation | movement which alert | reports a cleanliness, based on the count value by the biological particle counting means 3, more appropriate predetermined operation | movement according to a treatment process and a washing | cleaning disinfection process can be performed.

  In addition, according to the present embodiment, in the cleaning / disinfecting step, cleaning or disinfection is additionally performed based on the count value by the biological particle counting means 3, so that cleaning or disinfection can be performed more reliably. . Furthermore, it has an introduction flow path L1a for guiding the predetermined liquid from the flow path for circulating the predetermined liquid to the biological particle counting means 3, and the cleaning / disinfecting step distributes hot water or disinfecting liquid to the flow path for circulating the predetermined liquid. Since the introduction of hot water or disinfecting liquid through the introduction flow path L1a can be restricted during the disinfecting process, the biological particle measuring means 3 is prevented from being damaged by the hot water or disinfecting liquid. Can do.

Next, a second embodiment according to the present invention will be described.
As in the first embodiment, the blood purification system according to the present embodiment is for supplying a predetermined concentration of dialysis fluid to a plurality of dialysis monitoring devices. As shown in FIG. A plurality of monitoring devices 1 (corresponding to the “blood purification means” of the present invention) installed in a dialysis room (treatment room) and a dialysis machine installed in a machine room that is different from the dialysis room in the medical field. It is mainly comprised from the liquid supply apparatus 2 (equivalent to the "supply means" of this invention). In addition, the same code | symbol is attached | subjected to the component similar to 1st Embodiment, and those description is abbreviate | omitted.

  Here, in this embodiment, the cleaning filter 15 and the biological particle counting means 3 are connected upstream of all the monitoring devices 1 in the pipe L1. The cleaning filter 15 is composed of a fine particle filtration filter for cleaning a predetermined liquid supplied to the monitoring device 1, and adsorbs fine particles such as biological particles (for example, an antibiotic having an affinity for biological particles is included). Adsorbed by a filter made of fiber).

  The biological particle counting means 3 according to the present embodiment includes one connected to the introduction flow path L1a extending from the upstream side of the cleaning filter 15 in the pipe L1 and one connected to the introduction flow path L1a extending from the downstream side. The biological particles of a predetermined liquid flowing on the upstream side and the downstream side of the cleaning filter 15 can be counted and compared, respectively. Then, the cleaning effect of the cleaning filter 15 can be evaluated according to the process signal by counting and comparing the biological particles of the predetermined liquid flowing on the upstream side and the downstream side of the cleaning filter 15 respectively. It is configured. For example, by comparing the number of biological particles obtained for each treatment and monitoring the values before and after the cleaning filter 15, it is confirmed whether or not the trapping state of the biological particles is reduced, and the cleaning filter 15 is cleaned. The effect can be evaluated.

  Further, as shown in FIG. 7, a single biological particle counting means 3 is provided at the tip of the introduction flow path L1a extending from the upstream side of the cleaning filter 15 and the tip of the introduction flow path L1a extending from the downstream side in the pipe L1. It is good also as what connected the valve means 16 which can open and close a flow path to each of the introduction flow path L1a extended from an upstream, and the introduction flow path L1a extended from a downstream while connecting. In this case, by alternately opening the valve means 16, it is possible to count and compare the predetermined liquid biological particles flowing upstream and downstream of the cleaning filter 15.

  The biological particle counting means 3 according to the present embodiment can count biological particles of a predetermined liquid flowing on the upstream side and the downstream side of the cleaning filter 15 and compare them, but the cleaning filter It is sufficient that biological particles of a predetermined liquid flowing at least on the downstream side of 15 can be counted, and the cleaning effect of the cleaning filter 15 can be evaluated according to the process signal. That is, the introduction flow path L1a that can introduce a predetermined liquid into the biological particle counting means 3 may be connected only to the downstream side of the cleaning filter 15.

  According to the above embodiment, the biological particle counting means 3 includes the predetermined filter that flows at least downstream of the cleaning filter 15 while the cleaning filter 15 that cleans the predetermined liquid supplied to the monitoring device 1 is provided. Since liquid biological particles can be counted and the cleaning effect of the cleaning filter 15 can be evaluated according to the process signal, the performance and life of the cleaning filter 15 can be accurately grasped. In particular, the biological particle counting means 3 is capable of counting and comparing biological particles of a predetermined liquid flowing on the upstream side and the downstream side of the cleaning filter 15, and according to the process signal, the cleaning filter 15. If the cleaning effect can be evaluated, it is possible to grasp in real time and accurately the extreme deterioration and life of the cleaning filter 15.

  Although the blood purification system according to the present embodiment has been described above, the present invention is not limited to this. For example, as shown in FIG. 8, the biological particle counting means 3 is disposed in the monitoring device 1. Also good. In this case, the applied monitoring device 1 (blood purification means) can introduce a dialyzer 8 into the dialyzer 8 (blood purifier) connected to a blood circuit (not shown) and the dialyzer 8, as shown in FIG. The dialysate introduction line L4, the dialysate discharge line L5 capable of discharging the drainage from the dialyzer 8, the dual pump 10, and the water removal pump 14 are configured. The symbol f in the figure indicates a filtration filter connected to the dialysate introduction line L4.

  The dialyzer 8 is for purifying blood circulating extracorporeally in the blood circuit. The connection ports 8a and 8b to which the proximal end of the blood circuit is connected are connected to the dialysate introduction line L4 and the dialysate discharge line L5, respectively. Connection port. The compound pump 10 is disposed across the dialysate introduction line L4 and the dialysate discharge line L5, and supplies the dialysate 8 to the dialyzer 8 via the dialysate introduction line L4, and dialyzer 8 via the dialysate discharge line L5. It drains the drainage from The dialysate discharge line L5 is connected to a bypass line L3 that bypasses the duplex pump 10, and a water removal pump 14 is connected to the bypass line L3. The dialysate introduction line L4 is connected to a dialysate extraction means B for collecting dialysate called a sample port.

  Here, the biological particle counting means 3 is connected between the filtration filter f and the dialysate extraction means B in the dialysate introduction line L4, and during the treatment process, the dialysate supplied to the dialyzer 8 or during the cleaning / disinfecting process. The biological particles in the washing liquid or the like can be counted. Thus, similarly to the above embodiment, the predetermined operation is performed based on the count value by the biological particle counting means 3, and the predetermined operation is determined according to the process signal.

  Furthermore, instead of the central system as described above, the present invention may be applied to a personal dialyzer. In this case, the personal dialysis apparatus (corresponding to the “blood purification means” of the present invention) is provided with a tank containing a dialysate stock solution or a disinfectant solution, and the clean water fed from the supply means and the tank. A dialysate having a predetermined concentration can be prepared using a dialysate stock solution or a diluted disinfectant can be prepared. In addition, the dialysate undiluted solution (predetermined liquid) supplied from the supply means may be prepared to prepare a dialysate having a predetermined concentration by the blood purification means for treatment.

  Furthermore, the biological particle counting means only needs to be able to count biological particles contained in a predetermined liquid supplied to the monitoring device 1 (blood purification means) in real time, and is limited to that of the present embodiment. Not. Further, the process performed based on the process signal may be other various processes, and the predetermined operation determined according to the process signal may be other various operations. In addition, in this embodiment, although it is set as the system which performs a hemodialysis treatment, you may make it apply to the blood purification system which performs another blood purification treatment.

  Biological particle counting means capable of counting in real time the biological particles contained in the predetermined liquid supplied to the blood purification means, and a predetermined operation is performed based on the count value by the biological particle counting means, As long as the predetermined operation is a blood purification system determined in accordance with the process signal, it can also be applied to a device to which other functions are added.

1 Monitoring device (blood purification means)
2 Dialysate supply device (supply means)
3 biological signal counting means 4 interface unit 5 control unit 6 interface unit 7 control unit 8 dialyzer (blood purifier)
9 Blood circuit 10 Duplex pump 11 Flow rate detection sensor 12 Fluid pressure detection sensor 13 Conductivity detection sensor 14 Water removal pump 15 Cleaning filter L1 Piping (flow path through which a predetermined liquid flows)
L1a introduction flow path

Claims (7)

A plurality of blood purification means to which a blood purifier for performing blood purification treatment on a patient is attached;
Supply means capable of supplying a predetermined liquid such as dialysate, dialysate stock solution, hot water, washing liquid or disinfectant to each of the blood purification means;
In a blood purification system in which a predetermined process in the plurality of blood purification means is performed based on a predetermined process signal set in advance,
Biological particle counting means capable of counting biological particles contained in the predetermined liquid supplied to the blood purification means in real time, and a predetermined operation is performed based on the count value by the biological particle counting means. In addition, the blood purification system, wherein the predetermined operation is determined according to the process signal.   The step performed based on the step signal includes a treatment step for performing blood purification treatment by the blood purification means, a cleaning / disinfecting step for washing or disinfecting the flow path through which the predetermined liquid is circulated, and the predetermined operation is The blood purification system according to claim 1, wherein the blood purification system is operated based on a count value by the biological particle counting means according to the treatment process or the cleaning / disinfecting process.   In the treatment step, the predetermined operation is a notification of the cleanliness of the predetermined liquid supplied to the blood purification means based on the count value obtained by the biological particle counting means, or the blood purification by the blood purification means. The operation of continuing or stopping the treatment is performed, and at the time of the cleaning / disinfecting step, the effect of cleaning or disinfection is monitored based on the count value by the biological particle counting means, or the flow path for circulating the predetermined liquid is used. The blood purification system according to claim 1 or 2, wherein the operation is to notify the degree of cleanliness.   4. The blood purification system according to claim 3, wherein in the washing and disinfecting step, the washing or disinfecting is additionally performed based on a count value obtained by the biological particle counting means.   In addition to having an introduction flow path for guiding the predetermined liquid from the flow path for circulating the predetermined liquid to the biological particle counting means, the cleaning / disinfecting step may include hot water or a disinfecting liquid in the flow path for circulating the predetermined liquid. The blood purification system according to any one of claims 2 to 4, further comprising a disinfecting step to be distributed, wherein the introduction of hot water or disinfecting liquid through the introduction channel can be restricted during the disinfecting step. .   A cleaning filter for cleaning the predetermined liquid supplied to the blood purification means is provided, and the biological particle counting means counts biological particles of the predetermined liquid flowing at least downstream of the cleaning filter. The blood purification system according to claim 1, wherein the cleaning effect of the cleaning filter can be evaluated according to the process signal.   The biological particle counting means is capable of counting and comparing the predetermined liquid biological particles flowing upstream and downstream of the cleaning filter, respectively, and according to the process signal, The blood purification system according to claim 6, wherein the purification effect can be evaluated.

Images