JP2016136872A - Medicine releaser - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a novel medicine releaser enabled by simple means to diffuse a medicine contained in a gel to diffuse gradually into the atmosphere.SOLUTION: A medicine releaser 1 comprises: a bag material 2; a gel 3 filled in said bag material 2; and a volatile medicine 4 carried by said gel 3. In the medicine releaser 4, said bag material 2 is so made of a gas barrier sheet that bag material 2 is made of gas barrier sheet, and that the marginal part of said bag material 2 is closed by sewing means using a needle and a string 5.SELECTED DRAWING: Figure 1

Description

  The present invention relates to a drug sustained-release device adapted to gradually dissipate a drug contained in a gel into the atmosphere.

  It is known that diseases such as malaria, yellow fever, proboscis fever, West Nile fever, and filariasis are caused by flying pests such as mosquitoes and flies. Since flying insect pests that transmit this kind of disease mainly lived in temperate regions throughout the year, this type of disease has hitherto been limited to this region.

  However, in recent years, an increase in the northern limit habitat of flying pests has been observed, and in Japan, means for efficiently removing flying pests has been demanded.

  At present, in order to control flying insect pests, a means for spraying an insecticide into the atmosphere is mainly used. However, the insecticidal component contained in the insecticide is also harmful to the human body, and there is a concern about the effect on the human body when used at a high concentration.

  Therefore, means for keeping away the flying pests from the living environment by avoiding the flying pests directly is developed (for example, see Patent Documents 1 and 2 below).

JP-A-5-339102 JP 2006-506062 gazette

  The “laminated body releasing a volatile active ingredient” disclosed in Patent Document 1 is characterized in that an adhesive layer is formed on one side of a swollen gel layer containing a volatile active ingredient, The pressure-sensitive adhesive layer is used in a state where it is stuck on the epidermis, and the volatile active ingredient contained in the swollen gel layer is released into the atmosphere to repel flying insect pests.

  However, in the means disclosed in Patent Document 1, the volatile active ingredient contained in the swollen gel layer is halved in a relatively short time of about 24 hours, so that the repellent effect is maintained over a long period of time. Was difficult.

  On the other hand, in the “dispenser” disclosed in Patent Document 2, a storage unit supporting a volatile substance is enclosed in a bag material made of a film having a two-layer structure including a first control element and a second control element. It has been made. And in said patent document 2, while making said 1st control element the material which the said volatile substance can permeate | transmit, making said 2nd control element the material which the said volatile substance cannot permeate | transmit, and also said 1st The speed at which the volatile substance is volatilized is controlled by providing a plurality of pores penetrating the front and back surfaces in the second control element.

  However, in controlling the volatilization rate of the volatile substance by the means disclosed in Patent Document 2, the selection of the first control element, the number of pores provided in the second control element, The size determination is very complex and it is difficult to control the permeability of the volatile material to the desired degree.

  The present invention has been developed in view of the above technical problem, and provides a novel drug sustained-release device in which a drug contained in a gel is gradually released into the atmosphere by simple means. For the purpose.

  In order to solve the above technical problem, a drug sustained-release device of the present invention comprises a bag material, a gel enclosed in the bag material, and a volatile drug carried on the gel. The drug sustained-release device comprises the bag material made of a gas barrier sheet so that the drug is diffused into the atmosphere through the edge of the bag material, and the edge of the bag material consists of a needle and a thread. It is characterized by being closed by means of sewing using (hereinafter referred to as “the present invention sustained release device”).

  In the sustained release device of the present invention, a preferred embodiment is one in which the diameter of the needle hole formed in the edge of the bag material by the needle movement is 0.8 to 2.0 mm.

  In the sustained release device of the present invention, a preferred embodiment is one in which the number of moving needles for closing the edge of the bag material is 5 to 15 needles / 30 mm.

In the sustained release device of the present invention, the gas barrier sheet preferably has a moisture permeability of 10 g / m ² · 24 hours or less.

  In the sustained release device of the present invention, it is preferable that the thread has a thickness corresponding to a sewing thread having a cotton count of 36 to 80.

  In the sustained release device of the present invention, a preferred embodiment is one in which a nonwoven fabric or a woven fabric is laminated on the inner surface of the bag material.

  In the sustained release device of the present invention, a preferred embodiment is one in which the drug is a repellent or a fragrance that generates a volatile component that repels flying insect pests.

  ADVANTAGE OF THE INVENTION According to this invention, the chemical | medical agent contained in the gel can be gradually diffused in air | atmosphere through the edge part of a bag material.

FIG. 1 (a) is a perspective view showing the sustained release device of the present invention in a state where a part of the attachment is released, and FIG. 1 (b) is an XX sectional view of the sustained release device of the present invention. FIG.1 (c) is sectional drawing which expands and shows the attachment part. FIG. 2 is a perspective view showing another embodiment of the sustained release device of the present invention in a partially broken state. FIG. 3 is a cross-sectional view showing still another embodiment of the sustained release device of the present invention.

  Hereinafter, although the form (embodiment) for carrying out the present invention is explained based on a drawing, the present invention is not limited to this embodiment.

<Invention sustained release device 1>
FIG. 1 shows an embodiment of the sustained release device 1 of the present invention. The sustained-release device 1 of the present invention includes a bag material 2, a gel 3 enclosed in the bag material 2, and a volatile drug 4 carried on the gel 3.

-Bag material 2-
In the present embodiment, the bag material 2 is formed by superimposing a rectangular base material 21 and a covering material 22, and closing a peripheral edge by a sewing means using a needle (not shown) and a thread 5. It is a thing.

  The base material 21 and the covering material 22 constituting the bag material 2 are both gas barrier sheets.

In the present invention, the gas barrier sheet is preferably managed by moisture permeability. A preferable moisture permeability of the gas barrier sheet has a value measured by JIS Z0208 (cup method; 40 ° C .; 90% RH) of 10 g / m ² · 24 hours or less, more preferably 5 g / m ² · 24. The water vapor transmission rate is approximately 0 g / m ² · 24 hours. Note that the moisture permeability of the gas barrier sheet is measured in the direction from the inner surface of the bag material 2 toward the outer surface.

  The thickness of the gas barrier sheet is not particularly limited, but is usually 100 μm or less, preferably 10 to 80 μm, more preferably 20 to 60 μm, and particularly preferably 30 to 50 μm.

  Examples of the material constituting the gas barrier sheet include polyvinylidene chloride resins, linear low density polyethylene, polyesters, and polyamides. The concept of polyvinylidene chloride resins includes not only a vinylidene chloride homopolymer but also a copolymer of vinylidene chloride and other monomers, and a copolymer is preferred because of ease of processing. Used for.

  Further, a water vapor barrier property-imparting agent may be added to the material constituting the gas barrier sheet. Examples of the water vapor barrier property-imparting agent include fatty acid amide, bis fatty acid amide, paraffin wax, carnauba wax, montan wax, polyethylene wax, and petroleum resin.

  Furthermore, the material constituting the gas barrier sheet may contain not only the water vapor barrier property-imparting agent but also various additives. Examples of various additives include stabilizers such as plasticizers and heat stabilizers, antioxidants, lubricants, dispersion aids, ultraviolet absorbers, and surfactants.

  And the said gas-barrier sheet | seat can be manufactured by a normal method. For example, the production of a gas barrier sheet comprising a polyvinylidene chloride resin or linear low-density polyethylene as a main constituent polymer uses a compound containing a polymer and various additives, and uses melt extrusion molding and uniaxial or biaxial stretching. It is executed by doing.

  The gas barrier sheet is not limited to a single layer, and may have a multilayer structure in which two or more polymer sheets of different materials are fused or bonded. The kind of each layer which comprises such a gas barrier sheet | seat of a multilayer structure is not specifically limited. As an example, at least one of the plurality of layers may be one containing, as a main component, a polyvinylidene chloride-based resin exhibiting low moisture permeability or linear low density polyethylene. In this case, examples of the polymer that is the main component of the other layer include polyethylene terephthalate (PET), various polyethylenes, polypropylene, polyamide, and the like that are excellent in strength. In addition, polymers such as polyesters other than PET, polycarbonate, polyimide, polyacetal, polyvinyl alcohol, polystyrene and the like can also be used as the material for the polymer sheet.

  Polyvinylidene chloride-based polymer sheets tend to have poor adhesion to polymer sheets of other materials, so when laminated with polymer sheets of other materials to form a multilayer structure, polyvinylidene chloride It is preferable to corona-treat the surface of the system polymer sheet that faces the other polymer sheet.

Furthermore, the gas barrier sheet may contain other than the polymer sheet. As an example, there is one in which a polymer sheet and a metal foil are laminated. The gas barrier sheet containing such a metal foil has a moisture permeability of approximately 0 g / m ² · 24 hours. Moreover, as a kind of metal which comprises metal foil, aluminum, gold | metal | money, silver, copper, iron, nickel, palladium, platinum etc. and these alloys are mentioned. In addition, although the thickness of metal foil is not specifically limited, About 10 nm-about 500 micrometers are preferable. The thickness is selected in consideration of the decrease in flexibility as the metal foil becomes thicker.

  As another example of the gas barrier sheet containing other than this type of polymer sheet, for example, a vapor deposition polymer sheet in which a metal-based or inorganic vapor deposition layer is provided on one surface of the polymer sheet may be mentioned. . Of course, there may be vapor-deposited layers on both sides. Here, examples of the metal material to be deposited include gold, silver, copper, palladium, platinum, aluminum, nickel, iron, tin and alloys thereof (for example, silver-palladium alloy), and oxides thereof (for example, oxidation). Aluminum, tin oxide, indium tin oxide, antimony tin oxide). Moreover, ceramics, silica, etc. are mentioned as an inorganic substance vapor-deposited.

  The thickness of the vapor deposition layer is not particularly limited as long as the gas barrier sheet exhibits a desired moisture permeability, but is preferably about 1 to 100 nm. Moreover, the production method of a vapor deposition layer is not limited, For example, it carries out by the vacuum vapor deposition method, sputtering method, ion plating method, chemical vapor deposition method, plasma chemical vapor deposition method, etc.

-Gel 3-
The gel 3 is a so-called hydrogel (hydrous gel) formed in a jelly-like or gel-like form with water-absorbing polymer as a dispersoid and water as a dispersion medium as essential components.

  The water-absorbing polymer is not particularly limited as long as it is a polymer material that smoothly absorbs water and gels by absorbing a large amount of water, and a known hydrophilic polymer material can be preferably used. . Specific examples of the water-absorbing polymer include hydrophilic hydrophilic polymers such as polyvinyl alcohol, polyvinyl pyrrolidone, polyacrylic acid and salts thereof, and maleic anhydride copolymers, natural hydrophilic polymers such as dextran, pullulan, and gelatin. Semi-synthetic compounds such as water-soluble polymers, methylcellulose, ethylcellulose, and carboxymethylcellulose. In the present invention, one or two or more selected from these water-absorbing polymers can be appropriately selected and used.

  Moreover, in this invention, you may mix | blend additives, such as a filler and surfactant, in the said gel 3 at the time of manufacture of the said gel 3 or after manufacture as needed.

  The filler plays a role in expressing various functions, such as a crosslinking agent and a bulking agent for crosslinking the water-absorbing polymer to adjust the viscosity of the water-containing gel and improving the shape retention. There is no particular limitation as long as it is present. Specific examples of the filler include kaolin, bentonite, permiculite, silica powder, clay, pearlite, zeolite, zinc white, titanium oxide, talc, aluminum chloride, aluminum sulfate, aluminum nitrate, aluminum hydroxide, potassium alum, and spherical cellulose. Organic spheroids such as polybutene, polyisobutylene, acetaldehyde, glutaraldehyde, glyoxal, dialdehyde starch, dimethyl ketone, and the like. These fillers can be used alone or in combination.

  On the other hand, the surfactant is added mainly for improving the dispersibility of the material. Specific examples of this surfactant include, for example, higher fatty acid soap, alkyl sulfate ester salt, polyoxyethylene alkyl ether sulfate salt, acyl N-methyl taurate salt, alkyl ether phosphate ester salt and N-acyl amino acid salt. Anionic surfactants, cationic surfactants such as alkyltrimethylammonium chloride, dialkyldimethylammonium chloride and benzalkonium chloride, alkyldimethylaminoacetic acid betaines, alkylamidodimethylaminoacetic acid betaines and 2-alkyl-N-hydroxyimidazolium betaines Amphoteric surfactants such as polyoxyethylene type and polyhydric alcohol ester type and nonionic surfactants such as ethylene oxide / propylene oxide block copolymers, or sorbitan monolaurate, etc. Polymeric surfactants, mention may be made of other surfactants such as natural surfactants.

-Drug 4-
The drug 4 is a substance having volatility and is not particularly limited as long as it exhibits a function according to the volatile component (for example, disinfection, aroma, repelling, attracting, etc.). In particular, in the present invention, it is preferable to use a repellent or a fragrance that produces a volatile component that repels flying pests as the drug 4.

  Here, specific examples of repellents that generate volatile components that repel flying pests include N, N-diethyl-m-toluamide, dimethyl phthalate, dibutyl phthalate, dichlorobenzene, diphenyls, pentachlorophenol, and isobarrel. Aldehyde, salicylaldehyde, di-n-propylisocincomeronate, 2-ethyl-1,3-hexanediol, linalol oxide, phenylacetic acid derivative, camphor white oil, N-octylbicycloheprotendicarboximide, butadiene- A furfural copolymer is exemplified.

  On the other hand, specific examples of fragrances that generate volatile components that repel flying insects include α-amylcinnamaldehyde, methyl alantranilate, isoeugenol, γ-undecalactone, ethyl vanillin, eugenol, coumarin, cinnamon alcohol, cinnamon aldehyde , Methyl cinnamate, ethyl cinnamate, geraniol, geranyl acetate, citronellyl acetate, cinnamyl acetate, terpinyl acetate, phenylethyl acetate, butyl acetate, isoamyl acetate, 1-menthyl acetate, linalyl acetate, methyl salicylate, citronellol, citronellal, decylaldehyde, γ-nonalactone, vanillin, paramethylacetophenone, hydroxypropylcellulose, piperonal, phenylethyl alcohol, phenyl ethyl acetate, benzyl alcohol, methyphenyl In addition to chemical substances such as xanthone, l-menthol, yonon, linanol, citral, borneol, terpineol, neroline, diphenyl oxide, acinic aldehyde, dl-camphor, turpentine oil, citronella oil, lemongrass oil, lemon eucalyptus oil, nutmeg oil , Extraction oils such as cedar leaf oil, potato incense, dragon scent incense, lavender oil, thymol, and the like.

  In this embodiment, for convenience of explanation, the drug 4 is in the form of solid particles and is supported in a dispersed state on the gel 3, but the dosage form of the drug 4 is particularly limited. It is not a thing and may be solid or liquid. The drug 4 may be carried on the gel 3 after being encapsulated in a water-soluble capsule, for example.

<Production of the sustained release device 1 of the present invention>
In the sustained release device 1 of the present invention according to this embodiment, the gel 3 carrying the drug 4 is applied to the central portion of the base material 21, and the covering material 22 is applied to the coating surface of the base material 21. After overlapping from the side, the peripheral edge is closed by means of sewing using a needle (not shown) and the thread 5. In this embodiment, the stitching is performed by so-called “sewing”, but the stitching may be performed by so-called “hand stitching”.

  As shown in FIGS. 1 (a) and 1 (b), the sustained release device 1 of the present invention constructed as described above has a needle hole 6 formed at the edge of the bag material 2 by the needle movement of the needle. The In addition, a fine gap is formed between the needle holes 6 adjacent to each other along the needle movement direction at the edge of the bag material 2 closed by the sewing means.

  And since both the said base material 21 and the said covering material 22 which comprise the said bag material 2 are gas-barrier sheets, the volatile component volatilized from the said chemical | medical agent 4 currently carry | supported by the said gel 3 is sewn together. It diffuses into the atmosphere through the edge of the bag material 2 closed by means.

  At this time, since the needle hole 6 that functions as a vent hole through which the volatile component passes and the gap between the adjacent needle holes 6 are fine, the volatile component is diffused into the atmosphere over a long period of time. continue. Moreover, drying of the gel 3 enclosed in the bag material 2 is also suppressed over a long period of time.

  Here, the amount of diffusion of the volatile component per unit time mainly depends on the diameter of the needle hole 6 formed in the edge of the bag material 2 by the needle movement and the edge of the bag material 2. It can be controlled by the number of stitches of the yarn to be closed.

  In the present invention, the diameter of the needle hole 6 formed in the edge of the bag material 2 by the needle movement is 0.8 to 2.0 mm (more preferably 1.0 to 1.4 mm, still more preferably). Is preferably 1.05 to 1.2 mm). The diameter of the needle hole 6 can be determined by the thickness of the needle used for sewing. Specifically, the needles used at the time of sewing may be those having a domestic count of 11 to 25 (more preferably 15 to 22, more preferably 16 to 20).

  On the other hand, the number of needles of the thread 5 that close the edge of the bag material 2 is 5 to 15 needles / 30 mm (more preferably, 7 to 13 needles / 30 mm, and still more preferably 9 to 11 needles / 30 mm). It is preferable to do.

  Further, the thread 5 used for closing the edge of the bag material 2 reduces the opening area of the needle hole 6, so that the thickness of the thread 5 is not limited to the amount of volatile components emitted per unit time. Influence. In the present invention, it is preferable to use the thread 5 having a thickness corresponding to a sewing thread of cotton count 36 to 80 (more preferably 40 to 60).

  In this embodiment, all the edges existing on the peripheral edge of the bag material 2 are closed by the sewing means. In the present invention, “closing the edges by the sewing means” is shown in FIG. As shown, a part of the edge portion of the bag material 2 is closed by sewing, and the other edge portion (23) is closed by a means such as heat sealing.

  Furthermore, in this embodiment, although the said bag material 2 is comprised using the gas barrier sheet of a single layer, in this invention, as shown in FIG. It is preferable to laminate the woven fabric 7).

  If a non-woven fabric (or woven fabric) 7 is laminated on the inner surface of the bag material 2, the gel 3 contained in the bag material 2 is held in a state of biting into the fiber network of the non-woven fabric (or woven fabric) 7. Therefore, the movement and bias of the gel 3 can be preferably prevented.

[Examples 1 to 6]
-Bag material-
^Two rectangular (200 mm × 120 mm) linear low-density polyethylene sheets (thickness: 40 μm, moisture permeability: 6.8 g / m ² · 24 hours) were used as the gas barrier sheet constituting the bag material.

-Gel (with drug loaded)-
As a gel carrying a drug, a gel having the composition shown in Table 1 below was used.

-Manufacture of sustained release device of the present invention-
Apply 5 kg / m ^{2 of the} gel on the center of one gas barrier sheet, overlap the other gas barrier sheet from the coated surface side, and use the needle and thread at the peripheral edge. The sustained release device of the present invention according to Examples 1 to 6 was obtained by closing with the sewing means (sewing machine sewing). The conditions for stitching the edge were as shown in Table 2 below.

[Comparative Example 1]
A gel sheet according to Comparative Example 1 was obtained by applying 5 kg / m ^{2 of the} gel carrying the drug on the center of the gas barrier sheet. That is, the gel sheet according to this comparative example is in a state where one side surface is open to the atmosphere.

[Comparative Example 2]
Apply 5 kg / m ^{2 of the} gel on the center of one gas barrier sheet, overlap the other gas barrier sheet from the coated surface side, and seal the peripheral edge with heat seal. By closing, the bag material sealing gel concerning the comparative example 2 was obtained.

-Flying insect repellent test-
The sustained release device of the present invention according to Examples 1 to 6 was subjected to a flying insect pest repellent test. This flying insect repellent test was conducted according to the following conditions.

<Conditions>
The sustained release device of the present invention is placed on the bottom of a cubic acrylic container having a side of 300 mm, and 30 mosquitoes (adult females of human white stripes, non-blood-sucking) are placed in the container (29.4). C., 65% RH).

  In this test chamber, a mouse placed in a wire mesh bag is placed on the sustained release device of the present invention, and the number of mosquitoes that have landed on the mouse is counted at 30 second intervals for 10 minutes after the start of the test.

  Furthermore, after a week has passed, the flying pest repellent test is performed again under the same conditions, and the total number of mosquitoes that have landed on the mice is counted for 10 minutes after the start of the test.

  In addition, about the gel sheet which concerns on the said comparative example 1, and the bag material sealing gel which concerns on the said comparative example 2, the flying insect pest repellent test was done on the same conditions. The results are shown in Table 3 below.

  From the results shown in Table 3, it was confirmed that the sustained-release device of the present invention has an effective flying insect repellent effect, and the effect is maintained even after one week.

  On the other hand, the gel sheet according to Comparative Example 1 showed a flying insect pest repellent effect comparable to that of the sustained release device of the present invention for 10 minutes after the start of the test, but the effect was almost lost in the retest after one week. It was recognized that

  In addition, since the gel containing bag material according to Comparative Example 2 was blocked by the gas barrier sheet and volatile components were not diffused out of the bag material, it was recognized that the flying insect pest repellent effect was not expressed.

  By the way, the present invention can be implemented in various other forms without departing from the spirit or main features thereof. Therefore, the above-mentioned embodiment is only a mere illustration in all points, and should not be interpreted limitedly. The scope of the present invention is indicated by the claims, and is not restricted by the text of the specification. Further, all modifications and changes belonging to the equivalent scope of the claims are within the scope of the present invention.

  The sustained-release device of the present invention gradually releases the drug contained in the gel into the atmosphere, and can be used for various applications depending on the function of the volatile component that volatilizes from the drug.

1 Drug sustained release device (the sustained release device of the present invention)
2 Bag material 3 Gel 4 Drug 5 Yarn 6 Needle hole 7 Non-woven fabric (woven fabric)

Claims (7)

A drug sustained-release device comprising a bag material, a gel enclosed in the bag material, and a volatile drug carried on the gel,
So that the drug is diffused into the atmosphere through the edges of the bag material,
The bag material comprises a gas barrier sheet,
The medicine sustained-release device, wherein an edge of the bag material is closed by means of sewing using a needle and a thread. The drug sustained-release device according to claim 1,
A drug sustained-release device in which a diameter of a needle hole formed in an edge of the bag material by the needle movement is 0.8 to 2.0 mm. The drug sustained-release device according to claim 1 or 2,
The drug sustained-release device in which the number of needle movements of the yarn that closes the edge of the bag material is 5 to 15 needles / 30 mm. In the medicine sustained release device according to any one of claims 1 to 3,
A drug sustained-release device wherein the gas barrier sheet has a moisture permeability of 10 g / m ² · 24 hours or less. The drug sustained release device according to any one of claims 1 to 4,
A drug sustained-release device wherein the yarn has a thickness corresponding to a cotton yarn of cotton count 36-80. The drug sustained release device according to any one of claims 1 to 5,
A drug sustained-release device comprising a non-woven fabric or a woven fabric laminated on the inner surface of the bag material. The drug sustained release device according to any one of claims 1 to 6,
A drug sustained-release device, wherein the drug is a repellent or a fragrance that produces a volatile component that repels flying insect pests.

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