JP2016112089A - Blood purification system and blood purifier - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a blood purification system, in which plural blood purifiers having a supply port and a discharge port of blood, are connected directly.SOLUTION: The blood purification system is configured so that, plural blood purifiers having a supply port and a discharge port of blood, are directly connected and used. The blood purifiers are directly connected via lure lock connection mechanisms disposed on the respective ports, and in the respective plural blood purifiers, different substances are removed from the blood, each other.SELECTED DRAWING: Figure 1

Description

  The present invention relates to a blood purification system and a blood purification device.

  In artificial dialysis that is preferably used for patients with renal failure, long-term dialysis patients with a history of dialysis of 10 years or more are increasing due to advancement of dialysis equipment and technology, and complications peculiar to long-term dialysis patients are regarded as problems. Thus, a method for efficiently removing the etiological (related) substance of complications is disclosed.

  For example, Patent Document 1 describes a blood purifier for removing small molecular weight proteins that cause complications. The blood purifier is connected to a hemodialyzer that is one of the blood purifiers. A blood purification device is disclosed.

  Further, for example, Patent Document 2 discloses a treatment method in the case where a blood perfusion and blood adsorption blood purification module and a hemodialysis, blood filtration and hemodiafiltration blood purification module are used in a line. Yes.

  When these blood purifiers are used in combination, it is preferable that they are connected in a row in terms of setting and removal efficiency of pathogenic substances in the blood, but the connection between the two is a dedicated elastic resin blood circuit It was to connect via.

JP-A-9-266948 JP 2006-305306 A

  However, the conventional technique has the following problems. That is, when a plurality of blood purifiers are used in combination, the blood volume to be taken out of the body increases, and there is a concern that the blood pressure will decrease. Therefore, it has been required to minimize the blood volume.

  Also, blood purifiers, for example, hemodialyzers, which are one of blood purifiers and blood purifiers, use a dedicated blood circuit for their connection. It is necessary to fix the hemodialyzer with a dedicated clamping device, and then connect both via a dedicated blood circuit. For this reason, two dedicated clamping devices, which were sufficient in the past, are required, setting takes time, and complicated work such as taking into account the piping space of a dedicated blood circuit that connects the two is required. It was necessary.

  In addition, before dialysis treatment, it is necessary to perform an operation called priming that replaces air or filling liquid in the blood purifier with physiological saline. In this priming operation, the blood purifier may be turned upside down to promote the replacement. The reversing operation requires that each blood purifier is first removed from the dedicated clamping device, then reversing, reattaching and working with both hands is very poor, and workability is very poor, and when multiple blood purifiers are connected. It was difficult to work alone.

  It is an object of the present invention to minimize the volume of blood taken out of the body in the use of a blood purification system in which a plurality of blood purifiers having blood supply and discharge ports are directly connected and used. An object of the present invention is to provide a blood purification system capable of simplifying the operation of connecting a purifier, and a blood purifier used therefor.

In order to solve the above problems, the present invention is a blood purification system in which a plurality of blood purifiers having blood supply and discharge ports are connected and used.
The blood purifiers are directly connected via a luer lock connection mechanism provided in each port, and the plurality of blood purifiers provide a blood purification system in which substances mainly removed from blood are different from each other.

  At least one of the blood purifiers is preferably provided with a support mechanism that substantially fixes the connection between the plurality of blood purifiers on the outer peripheral side of one or both of the male luer and female luer. .

  One of the blood purifiers used in the blood purification system is a blood purification function body that removes at least a substance to be removed from blood, a case that houses the blood purification function body, and blood purification. A supply port for supplying to the vessel and a discharge port for discharging the blood from the blood purifier, and the connection mechanism provided in each of the supply and discharge ports is a luer lock, one is a male luer and the other is a female luer A blood purifier is provided.

  By using the blood purification system and blood purifier of the present invention, the volume of blood taken out of the body can be minimized. In addition, since a dedicated blood circuit is not required, setting can be simplified and the piping space of the blood circuit can be reduced.

  Further, by providing a support mechanism for substantially fixing the connection between the plurality of blood purifiers on the outer peripheral side of the luer lock provided in the port of the blood purifier, not only the setting but also the subsequent priming This is also advantageous in terms of improving workability.

BRIEF DESCRIPTION OF THE DRAWINGS It is a schematic block diagram of the connection mechanism of the blood purifier which concerns on one Embodiment of this invention, and the blood purification system using the same, (A) is the state before the connection by a connection mechanism, (B) is the state after a connection, respectively. Show. In the blood purification system shown in FIG. 1, it is a schematic block diagram which shows another aspect of the blood purification apparatus which concerns on this invention, (A) shows the state before the connection by a connection mechanism, (B) shows the state after a connection, respectively. ing. Like FIG. 2, it is a schematic block diagram which shows another aspect of the support mechanism with which the blood purifier concerning this invention was equipped, (A) is the state before the connection by a connection mechanism, (B) is the state after a connection, respectively. Show. An example of a hemodialyzer that is one of blood purifiers is shown. The schematic block diagram of the conventional blood purification system is shown.

  The blood purification in the present invention refers to the purpose of removing a target pathogenic substance from blood by filtration, diffusion, adsorption or the like using the characteristics of a purification function body.

  Further, the plurality of blood purifiers used in the blood purification system of the present invention are different from each other mainly in substances to be removed from the blood. For example, even if a plurality of blood purifiers remove the substance A in common, if only one blood purifier removes another substance B, and also removes the substances A and B in common. When there is a significant difference between the removal rate of substance A and the removal rate of substance B, it can be said that “substances mainly to be removed from blood are different”. That is, for the purpose of using the blood purification system of the present invention, a plurality of blood purifiers containing materials having different properties are connected in a row and different “blood purification” is performed according to the characteristics of the respective purifiers. is there. Specifically, the materials, forms, etc. of the materials accommodated in the purifier are often different.

  Embodiments of the present invention will be described below with reference to the drawings.

  FIG. 2 shows a blood purification system according to an embodiment of the present invention, but the following preferred modes and examples are not limited to this case. In FIG. 2, the blood purifier 200 accommodates a purification function body 202 in a case 201, blood supply ports 203 communicating with the case 201, and blood discharge ports at both longitudinal ends of the case 201. 205 is provided. The external connection portion of the supply and discharge ports is a luer lock mechanism, the connection portion of the supply side port is a male luer 204, and the connection portion of the discharge side port is a female luer 206. However, in FIG. 1, the blood purifier 200 is disposed downstream of the blood purification system 100 with reference to the blood flow direction. However, since the blood purifier 200 can also be disposed upstream of the system, a blood supply port is provided. The connection part can be a female luer and the connection part of the discharge port can be a male luer.

  In addition, a support mechanism 207 capable of substantially fixing the connection between the blood purifier 200 and the second blood purifier 300 is provided on the outer peripheral side of the male luer 204.

  In the present embodiment, the shape and material of the case 201 are not particularly limited, and a cylindrical shape, an elliptical cylindrical shape, a rectangular cylindrical shape, or the like is used as the shape. In view of the assembly of the blood purifier, a cylindrical one is preferably used. The material is preferably a resin from the viewpoint of productivity. Specifically, polypropylene, polycarbonate, polystyrene, polyvinyl chloride and the like are preferably used. Polypropylene and polycarbonate have moldability, strength, chemical resistance, etc. Polycarbonate is preferable, and polycarbonate is more preferable from the viewpoint of safety because it has high transparency and the state in the blood purifier can be visually confirmed.

  The form and material of the purification function body 202 are not particularly limited, but the arrangement form of the purification function body is an axial flow type in which the inflow direction and the outflow direction of blood are parallel to the purification function body, or the inflow direction. There is a radial flow type in which the outflow direction is vertical. Examples of the form of the purification functional body include membrane forms, that is, hollow fiber, solid thread membranes, woven fabrics, nonwoven fabrics, beads, or combinations thereof. The form of the purification function body 202 is properly used depending on the liquid to be processed or processing conditions.

  Examples of the material include cellulose, cellulose derivatives, polymethyl methacrylate (PMMA), polysulfone, activated carbon and the like.

  The blood purifier is provided with a liquid supply port and a discharge port, and the arrangement and number thereof can be arbitrarily determined according to the method of use. In general, as shown in FIG. The two are provided at two longitudinal end portions of 201 and communicate with the inside of the column. In this case, each column is connected in series. On the other hand, when the ports are provided at locations other than the two longitudinal ends of the case, the columns are not necessarily connected in a straight line. The material of each port is not particularly limited as is the case material, but the same material as the case is preferably used.

  As described above, in the present invention, the supply and discharge ports are provided with a luer lock mechanism for connecting an external pipe. However, the luer lock in the present invention is a simple, inexpensive, and reliable connection mechanism. One of the piping and port side connection part is provided with a female luer with a spiral groove of a predetermined shape, and the other is provided with a male luer with a spiral ridge that fits into the groove. By rotating one, liquid-tight connection is achieved.

  The male luer 204 and the female luer 206 which are the connection parts are preferably molded integrally with each port from the viewpoint of productivity, but the connection parts are flexible in order to improve the liquid tightness of the connection parts. It is also possible to mold with resin and integrate with each port separately.

  FIG. 5 shows a conventional blood purification system. As described above, in the conventional blood purifier, since the shape of the external connection part of the supply and discharge ports is all formed by a female luer, when connecting a plurality of blood purifiers in a row, the blood purifiers are dedicated to each other. Had to be connected through the blood circuit.

  On the other hand, as shown in FIG. 1, the blood purification system according to the present invention luer-locks a male luer 204 of the blood purification device 200 and a female luer 304 that is an external connection portion of the second blood purification device 300. Thus, blood purifiers can be directly connected to each other without using a dedicated blood circuit. In addition, if the luer lock mechanism of the connection portion has a shape conforming to ISO594-2, it can be connected regardless of manufacturer or product.

  As described above, the male luer 204 of the blood purifier 200 and the female luer 304, which is the external connection portion of the second blood purifier 300, can be connected to each other without using a blood circuit. However, for the purpose of reducing the load generated at the luer lock connecting portion during use, as described above, the second blood purifier 300 may be brought into contact with the outer peripheral side of the luer lock, for example, the outer peripheral side of the male luer 204. A possible support mechanism 207 may be provided.

  In the case of the embodiment shown in FIG. 2, the support mechanism 207 causes the second blood purifier when the male luer 204 of the blood purifier 200 and the female luer 304 of the second blood purifier 300 are connected by a luer lock. The front end surface of the female luer outer nozzle 306 of 300 and the support mechanism seat surface 209 of the blood purifier 200 form a stopper structure. The blood purifier 200 and the second blood purifier 300 can be substantially fixed in a state where the load generated on the male luer 304 and the inner nozzle 305 is reduced. It is possible to reduce the risk of damage to the male luer 204 and the inner nozzle 305 due to impact during use.

  When the port 203 and the support mechanism 207 shown in this embodiment are integrated, the port 203 and the support mechanism 207 are formed separately and integrated by post-processing such as ultrasonic welding. It can also be converted.

  FIG. 3 illustrates a support mechanism different from that shown in FIG. After the blood purifier 200 and the second blood purifier 300 are connected by a luer lock, the blood purifier 300 is provided with a support mechanism 207 provided in advance on the outer peripheral side of the male luer using a slide mechanism 210 provided separately. The repulsive force is generated between the support mechanism 207 and the blood purifier 300 by sliding in the direction, contacting and pressing the blood purifier 300, and using the repulsive force, the blood purifier 200 and the blood purifier 300 Can be fixed substantially.

  As in the above two examples, the support mechanism 207 is provided on the outer peripheral portion of the luer lock of the blood purifier, and is brought into contact with another blood purifier to which the blood purifier in the blood purification system is connected. The connection of the purifier is substantially fixed.

  The shape, material, and mechanism of the support mechanism 207 are not particularly limited as long as the purpose of serving as a guide for substantially fixing the devices is achieved.

  For example, as for the shape, the cross-sectional shape perpendicular to the longitudinal direction of the support mechanism 207 is mainly the circular shape of the case 201 and the port 203 of the blood purifier 200, so that the support mechanism 207 is the same from the viewpoint of assembly. A circular shape is preferable. Further, the support mechanism 207 is pressed against the blood purifier 300 to generate a repulsive force at the contact surface, but if it is circular, the force acts uniformly in all directions, and the stability when fixed is improved. Therefore, the cross-sectional shape is preferably circular.

  The material of the support mechanism 207 is not particularly limited in the same manner as the material of the case, but is transparent from the viewpoints of formability, strength, and ease of visual recognition of the luer lock connection part and port part in the support mechanism. Resins are preferred. Specific examples include polycarbonate, polystyrene, polyvinyl chloride, and polypropylene.

  In the case of the embodiment shown in FIG. 3, the shape of the contact surface with the support mechanism 207 of the blood purifier 300 is an arbitrary shape, and therefore the end surface (contact surface with the blood purifier 300) on the outer side in the longitudinal direction of the support mechanism 207. By providing the cushion material 211, curved surface followability is improved, and the contact area with the blood purifier 300 is increased, so that a more stable fixed state can be obtained. When the thickness of the cushion material 211 is smaller than 0.5 mm, the deformation allowance is small, and when the thickness is larger than 10 mm, the deformation of the cushion material becomes large, and the rigidity when worn and fixed is lowered. Preferably, 1 mm or more is more preferable, while 10 mm or less is preferable and 5 mm or less is more preferable. The material of the cushion material 211 is not particularly limited, but rubber, thermoplastic elastomer, or soft resin is preferably selected.

  The slide mechanism 210 provided in the support mechanism 207 can slide in the longitudinal direction of the blood purifier 200 and can generate a repulsive force between the support mechanism 207 and its contact surface when connected. Well, can be designed arbitrarily. Specific examples of the slide mechanism 210 include, for example, a screw type that uses rotation of a screw, and a spring type that uses a restoring force of a spring.

  2 and 3, the support mechanism is provided on the outer peripheral side of the male luer, but may be provided on the outer peripheral side of the female luer. Further, by providing a slide mechanism on the outer peripheral side of the male luer and the female lure and making the support mechanism detachable from the slide mechanism, the support mechanism can be provided on any side or both sides depending on the intended use. Is possible.

  The blood volume of the blood purifier 200 of the present invention is not particularly limited, but when used in blood purification applications, the blood volume entering the blood purifier is less than 20 ml, so that the treatment time is reduced because the blood purification capacity is lowered. If the length is longer and larger than 200 ml, the amount of blood taken out of the body is large, and the risk of lowering blood pressure is increased. Therefore, the blood volume is preferably in the range of 20 to 200 ml, more preferably in the range of 40 to 120 ml. The total blood volume of the blood purification system 100 of the present invention is preferably 400 ml or less, more preferably 300 ml or less, from the physical burden on the patient.

When the purification function body 202 is a membrane, the total surface area in contact with the blood of the purification function body 202 is preferably in the range of 1 to 8 m ² due to the restriction of the blood volume.

  When the blood purifier 200 of this embodiment is used in combination with a plurality of blood purifiers, a dedicated elastic resin blood circuit (tube 701 in FIG. 5) for connecting the blood purifiers is not necessary and can be directly connected. Therefore, by reducing the blood volume corresponding to the blood circuit, it is possible to minimize the volume of blood taken out of the body, thereby contributing to a reduction in the treatment load on the patient. In addition, since the setting and handling required at the time of treatment can be performed easily and reliably, the system is suitable for purifying the blood of patients with renal failure.

DESCRIPTION OF SYMBOLS 100 Blood purification system 200 Blood purifier 201 Case 202 Purification function body 203 Supply port 204 Male luer 205 Outlet port 206 Female luer 207 Support mechanism 208 Support mechanism inner surface 209 Support mechanism seat surface 210 Slide mechanism 211 Cushion material 300 Second blood Purifier 301 Supply port 302 Female luer 303 Discharge port 304 Female luer 305 Inner nozzle 306 Outer nozzle 400 Connection mechanism 500 Conventional blood purification system 600 Third blood purifier 601 Supply port 602 Female luer 603 Discharge port 603 Female luer 700 Blood circuit 701 Tube 702 Male lure 703 Male lure

Claims (7)

A blood purification system in which a plurality of blood purifiers having blood supply and discharge ports are connected,
The plurality of blood purifiers are directly connected to each other via a luer lock connection mechanism in which a male luer and a female luer provided at each port are connected, and the plurality of blood purifiers are mainly connected with blood. Blood purification systems with different substances to be removed.   The blood purification system according to claim 1, wherein at least one of the blood purification devices is a hemodialyzer.   At least one of the blood purifiers includes a support mechanism that substantially fixes a connection between the plurality of blood purifiers on the outer peripheral side of one or both of the male luer and the female luer. The blood purification system as described in.   The blood purification system according to claim 3, wherein the support mechanism is provided on an outer peripheral side of the male lure. A blood purifier used in the blood purification system according to claim 1 or 2, wherein at least a blood purification function body for removing a substance to be removed from blood, a case for housing the blood purification function body, A blood supply port for supplying blood bodies to the blood purifier, and a blood discharge port for discharging blood from the blood purifier,
The blood purifier, wherein the connection mechanism provided in each of the supply and discharge ports is a luer lock, one is a male luer and the other is a female luer.   The support mechanism which fixes substantially the connection of the said blood purifier and the other blood purifier used for the said blood purification system is provided in the outer peripheral side of either the male lure or the female lure, or both. The blood purifier according to 1. The blood purifier according to claim 4, wherein the support mechanism is provided on an outer peripheral side of the male luer.

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