JP2015224889A5

JP2015224889A5 -

Info

Publication number: JP2015224889A5
Application number: JP2014108097A
Authority: JP
Filing date: 2014-05-26
Publication date: 2016-10-27
Anticipated expiration: 2034-05-26

Description

また上記課題を解決するために成された第２発明は、複数の検量点に基づいて作成された、多項式関数による測定値と定量値との関係を示す検量線を利用して、目的測定値に対応する定量値を導出する定量用データ処理装置であって、
a)目的測定値よりも測定値が小さい検量点が存在する場合に、その中で測定値が目的測定値に最も近い検量点を下側検量点として抽出する下側検量点抽出部と、
b)目的測定値よりも測定値が大きい検量点が存在する場合に、その中で測定値が目的測定値に最も近い検量点を上側検量点として抽出する上側検量点抽出部と、
c)前記検量線に照らして目的測定値に対応する定量値が複数存在する場合であって、下側検量点と上側検量点との両方が存在する場合に、前記目的測定値に対応する複数の定量値候補の中で、前記下側検量点に対応する定量値と前記上側検量点に対応する定量値との間の定量値範囲に含まれる定量値候補が妥当な解であると判断する定量値決定部と、
を備えることを特徴としている。 Further, the second invention made to solve the above-mentioned problems uses a calibration curve that is created based on a plurality of calibration points and indicates a relationship between a measurement value by a polynomial function and a quantitative value. A quantitative data processing device for deriving a quantitative value corresponding to
if a) test weight point measurement value is smaller than the target measurement value exists, extracting the lower search volume point measurements within which to extract nearest test weight point object measurement as the lower test weight point And
b) If the measured value is larger test volume point than objective measurement value exists, the upper test quantity point extraction unit measurements within which to extract nearest test weight point object measurement as the upper test amount points ,
in a case where the quantified value corresponding to the target measured value in light of the c) the calibration curve there are a plurality, in the case where there are both a lower test weight point and the upper inspection quantity points, corresponding to the target measurement value to among the plurality of quantitative values candidate, a quantitative value candidate is a valid solution contained in the quantified value range between the quantitative value corresponding to said upper test weight point quantitative value corresponding to the lower detection amount points A quantitative value determination unit that determines that there is,
It is characterized by having.

なお、上記定量値決定部は、定量値範囲に含まれる定量値候補が一つである場合には、その候補を定量結果とすればよいが、定量値範囲に含まれる定量値候補が複数ある場合には、いずれかを選択する必要がある。そこで、第２発明に係る定量用データ処理装置において好ましくは、定量値範囲に含まれる定量値候補が複数ある場合に、下側検量点と上側検量点のうち、測定値が目的測定値により近い方の検量点を見つけて直近検量点とし、検量線の極値に対応する定量値を境界として定量値が複数に区分されてなる領域の中で、直近検量点が存在する領域に含まれる定量値候補が唯一の妥当な解であると判断するとよい。 In addition, when there is one quantitative value candidate included in the quantitative value range, the quantitative value determination unit may use the candidate as a quantitative result, but there are a plurality of quantitative value candidates included in the quantitative value range. In case you need to choose one. Therefore, preferably in a quantitative data processing apparatus according to the second invention, when there are a plurality of quantitative values candidates included in the quantitative value range, out of the lower test weight point and the upper inspection quantity point, the measured value is the purpose measurements the most recent test quantity point locate towards the test volume point closer to, in areas where quantitative value as a boundary a quantitative value corresponding to the extreme value of the calibration curve is divided into a plurality, there are recent test quantity point It may be determined that the quantitative value candidate included in the region is the only valid solution.

また第２発明に係る定量用データ処理装置において、上記定量値決定部は、検量線に照らして目的測定値に対応する定量値が複数存在する場合であって、下側検量点と上側検量点とのいずれかしか存在しない場合に、その存在する下側検量点又は上側検量点が存在する領域に含まれる定量値候補が妥当な解であると判断する構成とするとよい。 In addition quantitative data processing apparatus according to the second invention, the quantitative value determining unit, in a case where the quantified value corresponding to the target measured value against a calibration curve there are multiple lower test weight point and the upper inspection If only one of the amount points does not exist, or when configured to determine quantitative value candidates included in a region below the detection amount point or upper inspection volume point to its presence there is a reasonable solution.

Claims

In a quantitative data processing apparatus for deriving a quantitative value corresponding to a measured value using a calibration curve indicating a relationship between a measured value and a quantitative value by a polynomial function created based on a plurality of calibration points,
a) an extreme value calculation unit for finding an extreme value of the calibration curve;
b) The quantitative value corresponding to the obtained extreme value is used as a boundary, and the quantitative value is divided into a plurality of regions, and the number of calibration points included in each region is obtained to extract the region where the number of calibration points is maximum. A quantitative value region extraction unit;
c) Determination of a quantitative value for determining that the quantitative value included in the region extracted by the quantitative value region extraction unit is an appropriate solution when there are a plurality of quantitative values corresponding to the measured value in light of the calibration curve And
A data processing apparatus for quantification, comprising:

A quantitative data processing apparatus for deriving a quantitative value corresponding to a target measurement value by using a calibration curve created based on a plurality of calibration points and indicating a relationship between the measurement value by a polynomial function and the quantitative value. ,
if a) test weight point measurement value is smaller than the target measurement value exists, extracting the lower search volume point measurements within which to extract nearest test weight point object measurement as the lower test weight point And
b) If the measured value is larger test volume point than objective measurement value exists, the upper test quantity point extraction unit measurements within which to extract nearest test weight point object measurement as the upper test amount points ,
in a case where the quantified value corresponding to the target measured value in light of the c) the calibration curve there are a plurality, in the case where there are both a lower test weight point and the upper inspection quantity points, corresponding to the target measurement value to among the plurality of quantitative values candidate, a quantitative value candidate is a valid solution contained in the quantified value range between the quantitative value corresponding to said upper test weight point quantitative value corresponding to the lower detection amount points A quantitative value determination unit that determines that there is,
A data processing apparatus for quantification, comprising:

A quantitative data processing apparatus according to claim 2,
The quantitative value determining unit, when the quantification value candidates included in the quantitative value range there are a plurality, of the lower test weight points with said upper test weight point, inspection measurements closer by the object measurement locate the quantity point and the nearest detection quantity point, the quantitative value corresponding to the extreme value of the calibration curve in the region where the quantitative value is divided into a plurality as a boundary, included in an area where the most recent test quantity point exists The quantitative data processing apparatus is characterized in that it determines that the quantitative value candidate to be determined is the only valid solution.

A quantitative data processing apparatus according to claim 3,
The quantitative value determining unit, in a case where the quantified value corresponding to the target measured value in light of the above calibration curve there are a plurality, in the case where only one of the lower test weight point and the upper inspection volume point does not exist, quantitative data processing apparatus characterized by quantitative value candidates lower test weight point or upper inspection quantity point is included in the area where there is judged to be reasonable solutions to its presence.

A quantitative data processing apparatus according to claim 1 or 2,
The quantitative value determination unit, when the quantitative value determined to be valid is a negative value, the negative value is used as a quantitative result as it is, or the quantitative result is replaced with zero and is identified as being replaced. A quantitative data processing apparatus characterized by performing possible display.

A quantitative data processing apparatus according to claim 5 for a chromatographic apparatus,
A data processing apparatus for quantification characterized in that a measured value is an area value or height value of a peak on a chromatogram, and a quantitative value is a concentration value of a sample component.