JP2015125000A - Electrolyte measuring device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an apparatus for measuring an electrolyte that can improve the reliability of measured data.SOLUTION: An apparatus for measuring an electrolyte comprises: a plurality of ion-selective electrodes each arranged on a respective channel where a sample and an internal standard liquid selectively flow; a control unit that receives electromotive forces generated by the plurality of ion-selective electrodes and determines measurement results on a plurality of measurement items in the sample based on the electromotive forces; and a display unit that displays the measurement results of the plurality of measurement items. When the control unit detects abnormality in the electromotive force generated by the ion-selective electrodes regarding one of multiple measurement items, the control unit makes the display unit display the fact that the generated electromotive force is abnormal regarding the measurement items except the one measurement item whose abnormality has been detected.

Description

  The present invention relates to an electrolyte measurement device, and more particularly to an electrolyte measurement device that measures an electrolyte using a plurality of ion selective electrodes.

  An electrolyte measurement device is a device that measures the concentration of specific ions (ion concentration) in a sample using blood, urine, or the like as a sample. Various types of electrolyte measuring devices are known, and in particular, electrolyte measuring devices that measure ion concentrations using ion-selective electrodes are widely used in the field of clinical examinations. In an electrolyte measuring apparatus using an ion selective electrode, a standard solution having a known ion concentration is measured and a calibration curve is created in advance. Next, the potential difference between the internal standard solution and the sample is obtained by the ion selective electrode, and the ion concentration in the sample is measured using a calibration curve prepared in advance. Such an electrolyte measuring device is described in Patent Document 1, for example. Further, this Patent Document 1 describes the logic for generating an alarm when an abnormality is detected during maintenance.

  Patent Document 2 describes an automatic analyzer, and shows that a display order is set according to a predetermined criterion when a plurality of abnormalities are detected for each measurement item.

Japanese Patent Laid-Open No. 2001-4586 JP-A-8-262031

  Unlike an automatic analyzer, in an electrolyte measuring device, a plurality of ion-selective electrodes are provided in one channel, and a sample and an internal standard solution selectively flow through the channel. Taking a sample as an example, the sample flows through the flow path so as to sequentially contact a plurality of ion selective electrodes provided in one flow path. In this case, one ion selective electrode corresponds to one measurement item. In other words, the measurement result for one measurement item is obtained based on the voltage generated in one ion selective electrode.

  Since a plurality of ion-selective electrodes are provided in one channel, it is possible to measure a plurality of measurement items almost simultaneously by injecting a sample into the channel, thereby improving the efficiency of the measurement. Is possible. In this case, for each of the plurality of measurement items, it is possible to provide logic (abnormality detection logic) for detecting whether or not the individually measured data is abnormal or a means for detecting abnormality (abnormality detection means).

  However, if each measurement item has an abnormality detection means or abnormality detection logic during measurement, an alarm is generated by detecting an abnormality related to a common part in the electrolyte measurement device. However, the abnormality detection logic of other measurement items may be a range that is not regarded as abnormal, and an alarm may not occur. In such a case, it cannot be said that the reliability of measured data is sufficient in an electrolyte measurement device that requires a highly accurate measurement result.

  An object of the present invention is to provide an electric field quality measuring apparatus capable of improving the reliability of measured data.

  Patent Document 1 does not recognize that the reliability of the electrolyte measuring device is improved by using an abnormality detected in a certain measurement item. Patent Document 2 is directed to an automatic analyzer.

  The above and other objects and novel features of the present invention will be apparent from the description of this specification and the accompanying drawings.

  Of the inventions disclosed in the present application, the outline of typical ones will be briefly described as follows.

  That is, the electrolyte measuring device receives a plurality of ion selective electrodes arranged in a flow path through which a sample and an internal standard solution selectively flow, and an electromotive force generated in the plurality of ion selective electrodes, and generates an electromotive force. A control device that obtains measurement results of a plurality of measurement items in the sample and a display device that displays the measurement results of the plurality of measurement items are provided. Here, when the control device detects that the electromotive force generated in the ion selective electrode is abnormal in one measurement item among the plurality of measurement items, The display device displays that it is abnormal.

  Thereby, when an abnormality is detected in the electromotive force in the ion selective electrode corresponding to one measurement item, the abnormality is also displayed in the other measurement items. The sample or internal standard solution flowing through the flow channel sequentially comes into contact with the ion selective electrode. Therefore, it is estimated that not only the ion-selective electrode corresponding to one measurement item but also an electromotive force generated by another ion-selective electrode is abnormal and corresponds to another ion-selective electrode. Abnormality is displayed in the measurement item. As a result, if an abnormality that is considered to be related to a common part in the electrolyte measurement device occurs, the abnormality is detected based on the information of the measurement item that detected the abnormality for the measurement item that did not detect the abnormality. Thus, the reliability of the measured data can be improved.

  In one embodiment, an abnormality is detected when the electromotive force generated by the ion selective electrode corresponding to one measurement item varies beyond a predetermined range or exceeds a predetermined value.

  In one embodiment, when other measurement items other than the one measurement item described above are requested as a measurement target, if an abnormality is detected in one measurement item, the other measurement items requested Is displayed as abnormal. Thereby, the abnormality detected in the measurement item which is not requested is reflected in the requested measurement item.

  Furthermore, in one embodiment, when displaying an abnormality, the measurement item that detected the abnormality is displayed. In one embodiment, a table is provided in the control device for setting a priority order for an abnormality to be displayed when an abnormality is detected in a plurality of measurement items.

  Of the inventions disclosed in the present application, effects obtained by typical ones will be briefly described as follows.

  An electrolyte measuring device capable of improving the reliability of measured data can be provided.

It is a block diagram which shows the structure of the electrolyte measuring device concerning embodiment. It is a schematic diagram which shows typically the structure of the principal part of the electrolyte measuring device concerning embodiment. FIG. 3 is a flowchart showing the operation of the electrolyte measuring device according to the first embodiment. FIG. 6 is a flowchart showing the operation of the electrolyte measuring device according to the second embodiment. It is a figure which shows the structure of the alarm addition condition table used when determining the priority of an alarm. It is a figure which shows an example of the measurement result display screen which displays an alarm. It is a figure which shows an example of the alarm screen which displays the detail of an alarm.

  Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings. Note that components having the same function are denoted by the same reference symbols throughout the drawings for describing the embodiment, and the repetitive description thereof will be omitted.

  In the following embodiments, when it is necessary for the sake of convenience, the description will be divided into a plurality of sections or embodiments. However, unless otherwise specified, they are not irrelevant to each other. There are some or all of the modifications, details, supplementary explanations, and the like. Further, in the following embodiments, when referring to the number of elements (including the number, numerical value, quantity, range, etc.), especially when clearly indicated and when clearly limited to a specific number in principle, etc. Except, it is not limited to the specific number, and may be more or less than the specific number. Further, in the following embodiments, the constituent elements (including element steps) are not necessarily indispensable unless otherwise specified and clearly considered essential in principle. Needless to say.

  Similarly, in the following embodiments, when referring to the shapes, positional relationships, etc. of the components, etc., the shapes are substantially the same unless otherwise specified, or otherwise apparent in principle. And the like are included. The same applies to the above numerical values and ranges.

(Embodiment 1)
FIG. 1A is a block diagram showing a configuration of electrolyte measuring apparatus 100 according to the first embodiment. FIG. 1B is a schematic diagram schematically showing the main part of the electrolyte measuring device 100. In FIG. 1A, the electrolyte measuring device 100 is not particularly limited, but can be broadly divided into an electrolyte measuring unit having ion-selective electrodes 4 to 6 and the like, and a control unit (control device) connected to the electrolyte measuring unit. ) And a display unit (display device).

  The electrolyte measurement unit is not particularly limited. In FIG. 1A, the sample container 1, the sample dispensing nozzle 2, the dilution tank 3, the ion selective electrodes 4 to 6, the comparison electrode 7, the sipper syringe 8, the internal standard. A liquid syringe 9, a diluent syringe 10, a pinch valve 11, a reference electrode two-way solenoid valve 12, a sipper syringe suction two-way solenoid valve 13, and a waste liquid discharge two-way solenoid valve 14 are provided. Further, the electrolyte measuring unit includes an internal standard solution discharge two-way solenoid valve 15, an internal standard solution suction two-way solenoid valve 16, a diluent discharge two-way solenoid valve 17, a diluent suction two-way solenoid valve 18, and a comparison. An electrode solution bottle 19, an internal standard solution bottle 20 and a diluent bottle 21 are provided.

  The control unit (control device) controls the electrolyte measurement unit, receives a signal from the electrolyte measurement unit, and causes the display unit (display device) to display the measurement result. The signal from the electrolyte measurement unit is, for example, an electromotive force measured by the electrolyte measurement unit. Although not particularly limited, the control unit includes an amplifier 22, an analog / digital converter (hereinafter referred to as an A / D converter) 23, a computer 24, a keyboard 25, and a memory 27 in FIG. ing. The display unit (display device) includes a monitor 26 that is a display.

  With reference to FIG. 1A, the operation of the electrolyte measuring apparatus 100 will be described first. The sample in the sample container 1 is sucked by a set amount by the sample dispensing nozzle 2 and discharged to the dilution tank 3. Further, the diluent in the diluent bottle 21 is discharged to the dilution tank 3 by the operations of the two-way electromagnetic valve 18 for sucking the diluent, the diluent syringe 10 and the two-way solenoid valve 17 for discharging the diluent. As a result, the sample discharged from the sample container 1 to the dilution tank 3 is diluted with the diluent.

  With the pinch valve 11 closed, the comparison electrode liquid in the comparison electrode liquid bottle 19 is transferred via the comparison electrode two-way electromagnetic valve 12 by the operation of the sipper syringe 8 and the two-way electromagnetic valve 13 for sucking the sipper syringe. The reference electrode 7 is sucked.

  Next, the sample diluted in the dilution tank 3 is sucked into the ion selective electrodes 4 to 6 by the sipper syringe 8, the sipper syringe suction two-way electromagnetic valve 13, and the pinch valve 11. In this embodiment, the ion selective electrode 4 is a Na (sodium) ion selective electrode, the ion selective electrode 5 is a K (calium) ion selective electrode, and the ion selective electrode 6 is It is a Cl (base) ion selective electrode. When the diluted sample comes into contact with the ion selective electrodes 4 to 6, an electromotive force corresponding to each ion concentration is generated in each of the ion selective electrodes 4 to 6. For example, the ion selective electrode 4 generates an electromotive force according to the concentration of Na ions. In this embodiment, the electromotive force generated in each of the ion selective electrodes 4 to 6 is measured using the voltage at the comparison electrode 7 as a reference voltage.

  Further, the internal standard solution in the internal standard solution bottle 20 is discharged into the dilution tank 3 by the operations of the internal standard solution suction two-way solenoid valve 16, the internal standard solution syringe 9, and the internal standard solution discharge two-way solenoid valve 15. Is done. In this case, the diluted sample and the internal standard solution are controlled to be transferred to the ion selective electrodes 4 to 6 alternately. The diluted sample and the internal standard solution are alternately brought into contact with the ion selective electrodes 4 to 6, so that each of the ion selective electrodes 4 to 6 has an electromotive force and an internal standard based on the diluted sample. An electromotive force based on the liquid is generated. This generated electromotive force is measured using the voltage at the reference electrode 7 as a reference voltage.

  The sample and the internal standard solution that have been measured are discharged out of the electrolyte measuring device 100 from the waste liquid flow path by opening the two-way solenoid valve 14 for discharging the waste liquid.

  The measured electromotive force is supplied from each of the ion selective electrodes 4 to 6 to the control unit via the signal wiring 28. The electromotive force (measured electromotive force) supplied via the signal wiring 28 is supplied to the amplifier 22 and amplified. After being amplified, it is converted into a digital signal by the A / D converter 23 and sent to the computer 24.

  A calibration curve is created using a standard solution whose concentration is known in advance. The created calibration curve is stored in the memory 27 in advance using an input device such as the keyboard 25, for example. The computer 24 performs an operation on the digital signal supplied from the A / D converter 23 based on a calibration curve stored in advance in the memory 27. That is, the computer 24 calculates the electrolyte concentration of the measured sample based on the calibration curve, and displays the result of the concentration calculation on a display device such as the monitor 26.

  Note that the reference voltage is also supplied from the comparison electrode 7 to the control unit via the signal wiring, but is omitted in FIG.

  FIG. 1B schematically shows a relationship between the ion selective electrodes 4 to 6 and the flow path 29 through which the sample and the internal standard solution flow as a cross-sectional view. Although not particularly limited, each of the ion selective electrodes 4 to 6 has the same configuration as each other. Therefore, the structure of the ion selective electrode 4 will be described as a representative. The ion-selective electrode 4 is provided with an ion-selective membrane 4b on the bottom surface (lower side in FIG. 1B) of the casing, and the space between the electrode 4a and the electrode-selective membrane 4 is filled with the electrode internal solution. The electrodes 4a, 5a and 6a are made of the same material in the ion selective electrodes 4 to 6, but the ion selective membranes 4b, 5b and 6b are made different in the ion selective electrodes 4 to 6. By changing the ion selective membrane, the ion selective electrode 4 functions as a Na ion selective electrode, the ion selective electrode 5 functions as a K ion selective electrode, and the ion selective electrode 6 is Cl. Functions as an ion selective electrode.

  Each of the ion selective electrodes 4 to 6 protrudes into a flow path through which the sample and the internal standard solution flow so that the ion selective membrane is in contact with the sample and the internal standard solution. In FIG. 1B, the sample and the internal standard solution are shown to flow from the ion selective electrode 4 to the ion selective electrode 6 (arrow A).

  The respective electrodes 4a, 5a, 6a of the ion selective electrodes 4, 5, 6 are connected to the control unit via signal wirings 28a, 28b, 28c (generically, signal wiring 28 in FIG. 1A). It is connected. Thereby, in the measurement, the electromotive force generated in each of the ion selective electrodes 4 to 6 is supplied to the control unit.

  In the electrolyte measuring apparatus 100 in this embodiment, instead of changing the sample and the internal standard solution for each measurement item, the sample and the internal standard solution flowing through the flow path 29 are used for the ion selective electrode 4 corresponding to the measurement item. Measurements are sequentially performed by ˜6. Therefore, it becomes possible to measure a plurality of measurement items in a short time. However, if the sample or / and the internal standard solution has an abnormality that affects each measurement item, the electromotive force of each of the ion selective electrodes 4 to 6 may change due to this influence. Conceivable.

  Further, since the sample is not changed for each measurement item, the electromotive force of the ion selective electrodes 4 to 6 is supplied to the control unit via the signal wirings 28a, 28b, and 28c within a short time. Therefore, when electrical noise is superimposed on the signal wirings 28a, 28b, and 28c, it is considered that changes due to the influence of noise are included in all measurement items.

  Note that the relationship between the ion selective electrode and the flow path illustrated in FIG. 1B is an example, and the present invention is not limited to this.

  Next, the operation of the first embodiment will be described with reference to FIGS. FIG. 2 is a flowchart showing the operation of the electrolyte measuring apparatus 100 according to the first embodiment.

  First, in step 201 (FIG. 2), a request for an item (measurement item) to be measured by the electrolyte measuring device 100 is generated using the keyboard 25 (FIG. 1A). The generated measurement items are stored in the memory 27 (FIG. 1A). Next, in step 202, the computer 24 instructs the electrolyte measurement unit to perform measurement in accordance with the measurement items stored in the memory 27. That is, the electrolyte measurement unit is controlled by the control unit including the computer 24. With this control, the electrolyte measurement of the sample is performed by the electrolyte measurement unit according to the procedure described above with reference to FIG. 1A, and the control unit calculates the electrolyte concentration based on the measured electromotive force. To do.

  Next, in step 203, the computer 24 determines whether there is an abnormality in the electrolyte concentration and / or the calculated electrolyte concentration (abnormality determination). If no abnormality is detected in step 203, the electrolyte measurement result is displayed on the monitor 26 (step 205). In this case, the monitor 26 displays the measurement item requested in step 201 and the electrolyte concentration in each item. Since no abnormality is detected, an alarm indicating abnormality is not displayed on the monitor 26 (no alarm).

  An example of detecting an abnormality in step 203 is as follows. When a measured value (for example, measured value of Na ion) measured by an ion selective electrode exceeds an upper limit value or a lower limit value of a preset range, the measured starting value is measured. A case where noise is superimposed on the power or a case where the measured electromotive force exceeds a predetermined range is detected as abnormal. In these cases, an abnormality is detected and an alarm is added as will be described later.

  In the electrolyte measuring apparatus 100, as described with reference to FIG. 1B, since a plurality of ion selective electrodes are connected to the same flow path, when the concentration of a certain specimen (sample) is measured, the same at a time. A sample or an internal standard solution is sequentially transferred to a plurality of ion selective electrodes, and an electromotive force is measured by the plurality of ion selective electrodes. Therefore, for example, when an abnormality is detected in the electromotive force generated in the ion selective electrode 4 for Na ion measurement, when the cause of the abnormality in the electromotive force is an internal standard solution, other items (K ion measurement) Item, Cl ion measurement item), it is conceivable that the abnormality of the internal standard solution affects the measurement values (K ion measurement value, Cl ion measurement value).

  Therefore, when it is determined that there is an abnormality in step 203 (YES), the computer 24 determines whether the detected abnormality further relates to the electromotive force (step 204). Here, the abnormality relating to the electromotive force is, for example, a case where the measured variation in electromotive force exceeds a predetermined range, or a case where the value of electromotive force exceeds a predetermined range. is there. In step 204, determination is performed for each measurement item. That is, the presence / absence of abnormality relating to electromotive force is determined for each ion selective electrode. 1A and 1B, the ion-selective electrode 4 corresponding to the Na measurement item, the ion-selective electrode 5 corresponding to the K measurement item, and the Cl measurement item will be described. It is determined whether or not the electromotive force generated in each of the ion selective electrodes 6 has an abnormal value.

  In any of the measurement items of Na, K, and Cl, if it is determined in step 204 that the abnormality is related to electromotive force (YES), variations in electromotive force measured in other electrolyte measurement items, Alternatively, and / or even if the value of the electromotive force is within a predetermined range, an alarm is added to all electrolyte measurement items based on the abnormality detected in step 204 (step 207). On the other hand, if it is determined in step 204 that there is no abnormality related to electromotive force in any measurement item (NO), an alarm is added only to the measurement item in which the abnormality is detected in step 203 (step 206). .

  As described above, according to the first embodiment, when the electrolyte measuring apparatus 100 detects an abnormality related to an electromotive force in a certain measurement item, the electromotive force measured with an ion selective electrode corresponding to another measurement item is abnormal. Even if the value is not shown, an alarm notifying an abnormality related to the electromotive force is added to all the measurement items of the measured electrolyte. As a result, it is possible to provide the electrolyte measuring apparatus 100 capable of improving the reliability of data obtained by measurement.

(Embodiment 2)
FIG. 3 is a flowchart showing the operation of the electrolyte measuring apparatus according to the second embodiment. By changing the program executed in the computer 24 shown in FIG. 1 (A), the electrolyte measuring device 100 shown in FIG. 1 (A) operates according to the flowchart shown in FIG. 2 or shown in FIG. The operation according to the flowchart is performed. Here, it is assumed that the program is changed so that the computer 24 operates according to the flowchart shown in FIG. Hereinafter, the operation of the electrolyte measuring apparatus 100 according to the second embodiment will be described with reference to FIGS. 1 and 3.

  First, as in the first embodiment, using the keyboard 25, a measurement item for measuring the electrolyte of the sample is generated, and an electrolyte measurement request is made (step 301). The measurement items generated here are stored in the memory 27. In the second embodiment, among the plurality of measurement items that can be measured by the electrolyte measurement device 100, some measurement items are requested as an electrolyte measurement request. For example, in the electrolyte measuring apparatus 100 shown in FIG. 1A, it is possible to request three items of Na, K, and Cl as measurement items. In Embodiment 2, the measurement items of these three items are requested. For example, it is assumed that one item (measurement item for measuring Na) is selected and a measurement request is made for the selected item (measurement item for Na).

  When a measurement request is made in step 301, step 302 is executed to measure the electrolyte measurement item (in the above example, the Na measurement item) for which the measurement request is generated. In step 302, the diluted sample and the internal standard solution are sucked into the ion selective electrode (Na ion selective electrode 4) corresponding to the electrolyte measurement item (Na measurement item) for which the measurement request is generated. The electromotive force generated in the ion selective electrode is measured, and the concentration of Na as a measurement item is calculated. That is, the electromotive force generated in the ion selective electrode (Na ion selective electrode 4) is supplied to the amplifier 22 of the control unit, and the concentration of the electrolyte Na that is a measurement item is calculated in the control unit.

  Based on the measured electromotive force and the calculated concentration of the electrolyte (Na), the computer 24 determines in step 304 whether or not an abnormality has occurred during the measurement. If it is determined that there is no abnormality in step 304 (NO), for example, the concentration of the requested measurement item (Na) is displayed on the monitor 26 as a measurement result (step 306). In this case, since it is determined that there is no abnormality, no alarm is added to the monitor 26 (no alarm).

  On the other hand, if it is determined in step 304 that there is an abnormality (YES), an alarm notifying the abnormality is added to the measurement item that detected the abnormality, and the measurement result is displayed on the monitor 26 (step 307). . That is, in this case, for example, the calculated concentration and the alarm are displayed on the monitor 26 as the measurement result.

  By the way, in the electrolyte analyzer 100 configured as shown in FIGS. 1A and 1B, the diluted sample and the internal standard solution are sequentially transferred to all the ionic selection electrodes 4-6. In other words, the sample and the internal standard solution alternately flow through the flow path in which all the ion selective electrodes 4 to 6 are arranged.

  In the second embodiment, when measuring the electromotive force using the ion selective electrode (ion selective electrode 4) corresponding to the measurement item (for example, Na measurement item) requested to be measured in step 302, The electromotive force generated at the ion-selective electrode (ion-selective electrode 5 and ion-selective electrode 6) corresponding to the measurement item (for example, the measurement item of K and Cl) that has not been requested for measurement is measured. As described above, since the sample and the internal standard solution are in contact with all the ion selective electrodes 4 to 6 by flowing through the flow path, an electromotive force is generated at each ion selective electrode and measured. This is because the electromotive force can be measured even for measurement items for which no measurement request is made. In FIG. 3, in step 303, the electromotive force is measured using the ion selective electrodes (5, 6) corresponding to the measurement items (K, Cl measurement items) for which no measurement request is made.

  Based on the electromotive force measured in step 303, the computer 24 determines in step 305 whether the measured electromotive force varies or the value of the electromotive force exceeds a predetermined value (range) and is abnormal. Judgment is made. That is, it is determined in step 305 whether or not the electromotive force generated by the ion selective electrode corresponding to the measurement item for which no measurement request has been made is abnormal. If an abnormality is detected in step 305 (YES), an alarm indicating the abnormality detected in step 305 is added to the measurement item requested to be measured (Na measurement item) (step 308). If no abnormality is detected in step 305, the process ends without executing anything.

  In step 303, based on the measured electromotive force, the concentration of the electrolyte (K, Cl) may be calculated for the measurement item for which no measurement request has been made.

  Thus, according to the second embodiment, the electromotive force is measured with the ion selective electrode corresponding to the electrolyte measurement item for which no measurement request is made, and if there is an abnormality, the measurement item for which the measurement request has been made. An alarm is added to. Thereby, the electrolyte measuring apparatus 100 which can improve the reliability of the measured data can be provided.

(Embodiment 3)
In a general electrolyte measurement device, when multiple abnormalities are detected for a certain measurement item, the most important of the detected abnormalities is due to the size and visibility of the monitor screen that displays the measurement results. Select one high anomaly and display it on the monitor screen. On the other hand, in Embodiments 1 and 2, when a certain measurement item is measured, an abnormality in another measurement item measured at the same time is added as an alarm and displayed. When a plurality of abnormalities are detected in a certain measurement item, the abnormality having the highest importance and the abnormalities in other measurement items measured simultaneously in the first and second embodiments are simultaneously displayed together with the measurement results in the certain measurement item. It can be displayed on a monitor. However, if this is done, the amount of alarms indicating an abnormality will increase, and the visibility of the user who handles the electrolyte measuring apparatus may be reduced or / and the operability may be deteriorated.

  In the third embodiment, an alarm addition condition table indicating the priority order for displaying an alarm when an abnormality is detected in a plurality of measurement items is added to the first and second embodiments described above. FIG. 4 is a diagram showing the alarm addition condition table 400. The alarm addition condition table 400 is a table that determines the priority order of abnormalities displayed on the monitor 26 when abnormalities are detected in a plurality of measurement items. This alarm addition condition table 400 is stored in the memory 27 in the electrolyte measuring device 100 and is referred to when the computer 24 displays the measurement result on the monitor 26. That is, when displaying the measurement result, the computer 24 selects an abnormality to be displayed according to the table 400 and displays it on the monitor 26.

  Although not particularly limited, the alarm addition condition table 400 is provided for each measurement item. Taking Embodiment 1 shown in FIG. 1A as an example, the measurement items are three items (Na, K, Cl). In each measurement item, the alarm addition condition table 400 has the same structure although the target measurement item (simply described as an item in FIG. 4) is different. Therefore, in FIG. 4, an alarm addition condition table 400 in the case where the target measurement item (item) is Na is shown as a representative. The alarm addition condition table 400 for other items K and Cl is omitted.

  In FIG. 4, 408 to 411 indicate columns of the alarm addition condition table 400, and 401 to 407 indicate rows of the alarm addition condition table 400. In the row 401 of the alarm addition condition table 400, a column 408 indicates a “measurement item” that is a target of the table 400, and a column 409 indicates a measurement item that is a target of the table 400. When displaying the measurement result of the Na measurement item on the monitor 26, the table 400 shown in FIG. 4 is used. In order to clarify this, an item “Na” is registered in the column 409 of the row 401. In the row 401, the remaining (other) measurement items are registered in a column 410. That is, the remaining two items “K, Cl” are registered. Further, a column 411 in the row 401 shows an alarm added when the measurement result of the measurement item is displayed using the table 400. In this example, since the measurement item is Na, an alarm to be added when displaying the measurement result of Na is shown.

  In column 409 of the alarm addition condition table 400, lines 402 to 407 include the presence / absence of an abnormality and the type (factor) of the abnormality when the measurement item (Na) that defines the condition for adding the alarm is measured using the table 400. ) Is registered. Here, lines 402 and 403 indicate that there is no abnormality in the measurement item (Na) when the measurement item (Na) is measured, and lines 404 and 405 indicate the measurement item (Na). When measured, an abnormality is detected in the measurement item (Na), indicating that the cause is other than the electromotive force. Further, rows 406 and 407 indicate that an abnormality is detected in the measurement item (Na) and that the cause is related to the electromotive force.

  In column 410 of the alarm additional condition table 400, lines 402 to 407 are detected in the measurement item (Na) that is the target of the alarm additional condition table 400 and other measurement items (K, Cl) that are simultaneously measured. Presence / absence of the abnormality and the cause of the abnormality are registered. Here, rows 402, 404, and 406 indicate that there is no abnormality in the measurement of other measurement items (K, Cl) or an abnormality is detected, but the cause is other than the electromotive force. In column 410, rows 403, 405, and 407 indicate that an abnormality is detected in the measurement of other measurement items (K, Cl), and that the factor relates to the electromotive force.

  In column 411 of the alarm addition condition table 400, lines 402 to 407 show alarms added when displaying the measurement result of the measurement item (Na) as an object of the table 400. Here, the row 402 indicates that there is no alarm to be added and displayed when displaying the measurement result of the target measurement item (Na). Lines 403 and 405 represent adding an alarm detected when other measurement items (K, Cl) are measured, and lines 404 and 406 are detected in measurement of the target measurement item (Na). It shows that the abnormalities that have been added are added. A row 407 indicates that an abnormality is detected in the measurement of all measurement items, and an abnormality having the highest priority ranking among them is added as an alarm.

  In the alarm addition condition table 400, rows 402 to 407 in the column 408 indicate the title “abnormality detected during measurement”.

  The computer 24 shown in FIG. 1A calculates the measurement result based on the electromotive force supplied from the electrolyte measurement unit via the amplifier 22 and the A / D converter 23, and sets the measurement item to the monitor 26. At the time of display, the alarm addition condition table 400 shown in FIG. 4 is referenced to determine whether or not to add an alarm and the alarm to be added. In other words, the presence / absence of an alarm added when displaying the measurement result of the target item corresponding to the combination of the presence / absence and type of the target item and the presence / absence and type of the other item The type is determined by the alarm additional condition table.

  The computer 24 does not detect any abnormality in the measurement item (item Na in the example of FIG. 4), and can measure other items (other items (K, Cl) in FIG. 4). When no abnormality is detected (in FIG. 4, there is no abnormality) or an abnormality that affects only the other items (in FIG. 4, an abnormality other than that caused by electromotive force), the row 402 of the alarm addition condition table 400 is selected. . By selecting the row 402, an alarm to be added to the measurement result of the measurement item Na is selected from the column 411 of the alarm addition condition table 400. That is, the row 402 in the column 411 of the alarm addition condition table 400 is selected. When the row 402 in the column 411 of the alarm addition condition table 400 is selected, the computer 24 recognizes “no alarm to display” when displaying the measurement result of the target item (Na), and the target item ( Only the measurement result of Na) is displayed on the monitor 26.

  If no abnormality is detected in the measurement item (Na), and an abnormality relating to electromotive force is detected in the measurement of other items (K, Cl), the row 403 in the column 411 of the alarm addition condition table 400 is selected. The Thereby, when displaying the measurement result of the item Na on the monitor 26, the computer 24 adds the abnormality detected in the other item as an alarm and displays it. In this case, as the abnormality added as an alarm, the abnormality determined to have the highest priority among the abnormalities relating to the electromotive force detected in other items is displayed.

  In the measurement of the measurement item (Na), an abnormality not related to the electromotive force (abnormality other than that caused by the electromotive force) is detected, and no abnormality is detected in the other items (K, Cl) (no abnormality), or the electromotive force is When an irrelevant abnormality (item alone abnormality) is detected, the row 404 in the column 411 of the alarm addition condition table 400 is selected. When the row 404 of the column 411 is selected, the computer 24 adds the abnormality detected by the measurement of the measurement item (Na) as an alarm when displaying the measurement result of the measurement item (Na). Also in this case, the abnormality having the highest importance among the abnormality detected in the measurement of the measurement item (Na) is added as an alarm and displayed together with the measurement result of the item (Na).

  When an abnormality not related to the electromotive force (abnormality other than that caused by the electromotive force) is detected in the measurement item (Na), and an abnormality related to the electromotive force is detected in the measurement of other items (K, Cl), the computer 24 Selects row 405 in column 411 of table 400. Thereby, when displaying the measurement result of the measurement item (Na) on the monitor 26, the abnormality detected by the other item (K, Cl) is added as an alarm. Also in this case, the abnormality with the highest priority among the abnormalities related to the electromotive force detected in the other items (K, Cl) is added and displayed as an alarm.

  In the measurement item (Na) measurement, an abnormality related to the electromotive force is detected, and in the measurement of other items (K, Cl), no abnormality is detected (no abnormality), or an abnormality not related to the electromotive force (other than the cause of the electromotive force) In the column 411 of the table 400 is selected. By this selection, the computer 24 adds the abnormality detected in the item (Na) as an alarm when displaying the measurement result of the measurement item (Na). Also in this case, the abnormality having the highest importance among the abnormality detected in the item (Na) is added as an alarm and displayed.

  When an abnormality relating to electromotive force is detected in the measurement item (Na) and an abnormality relating to electromotive force is detected in the measurement of other items (K, Cl), the row 407 in the column 411 of the table 400 is displayed. Selected. In this case, the measurement result of the measurement item (Na) is displayed with the abnormality having the highest priority among the abnormality detected in the measurement item (Na) and other items (K, Cl) to be displayed. When added as an alarm.

  For each of the other measurement items (K, Cl), as described above, a table similar to the alarm addition condition table 400 is provided. In this case, in the alarm addition condition table in which the item (K) is the measurement item to be displayed, the item Cl and the item Na correspond to other items. Similarly, in the alarm addition condition table in which the item (Cl) is a measurement item to be displayed, the item Na and the item K correspond to other items. When displaying the measurement result of the measurement item to be displayed using each alarm addition condition table, whether or not to add an alarm and the type of alarm to be added are determined. Of course, it is not necessary to provide an alarm additional condition table for all displayed measurement items, and an alarm additional condition table may be provided only for necessary measurement items.

  In this way, when an abnormality occurs in multiple electrolyte measurement items, it is possible to improve the reliability of data without complicating the screen display by setting the priority of alarms to be displayed in the measurement results. It becomes.

  Next, an example of a screen displayed on the monitor 26 will be described with reference to FIGS. FIG. 5 is a diagram showing a measurement result display screen displayed on the monitor 26, and FIG. 6 is a diagram showing an alarm screen displayed on the monitor 26.

  In FIG. 5, reference numeral 500 denotes a screen title “measurement result screen” displayed on the monitor 26. In this example, measurement results of a plurality of measurement items (Na, K, Cl) are collectively displayed as a table 502. In the table 502, 503 is a column that displays measurement items, 504 is a column that shows measurement results, 505 is a column that displays alarms, and 506 is a column that shows detection sites. Here, the column 505 is used as a display area for displaying the abnormality that affects the entire electrolyte measuring apparatus 100 detected in the first and second embodiments in addition to the measurement result. The column 506 is used as a display area for displaying a measurement item in which an abnormality that affects the entire electrolyte measuring apparatus 100 is detected.

  In the figure, rows 507 to 509 display measurement results of measurement items Na, K, and Cl, alarm types, and detection sites. For example, in the row 507, “Na” is displayed in the column 503 so as to indicate that the measurement item is the item Na, and the measurement result of the item Na is indicated by a number (120.0) in the column 504. Has been. In the first and second embodiments, the detected abnormality affecting the entire electrolyte measuring apparatus 100 is displayed as an alarm in the column 505 of the row 507, and in this example, “Noise” is displayed. . Since Noise is an abnormality that affects the entire electrolyte measuring apparatus 100, the measurement results are displayed in the column 504 and the alarm display column (display area) 505 for other measurement items (K, Cl). “Noise” is displayed. Further, in this example, in order to indicate that the measurement item that has detected an abnormality (Noise) that affects the whole is the item Na, in the column 506 of the detection region, the detection region is displayed in a row 507 corresponding to the item Na. A mark “?” Is displayed.

  In which measurement item an abnormality affecting the entire electrolyte measuring apparatus 100 is detected can be specified by the flowcharts shown in FIGS. 2 and 3. In FIG. 5, noise (Noise) is shown as an example of an abnormality that affects the whole. However, this is an example, and an abnormality such as an internal standard solution affects the whole.

  In the second embodiment, a measurement request is made only for a specific measurement item from among a plurality of measurement items. For example, a measurement request is made only for the measurement item (k) among the plurality of measurement items (Na, K, Cl) shown in FIG. In this case, the measurement result screen 500 displayed on the monitor 26 displays only the measurement result of the requested measurement item (K). At this time, for example, if an abnormality is detected in the electromotive force generated by the ion selective electrode corresponding to Na ion, the alarm column 505 is displayed when displaying the measurement result of the requested measurement item (K). An alarm will be displayed. Of course, in this case, since the detected part is different from the requested measurement item, the mark (?) Indicating the detected part is not displayed in the column 506.

  Thus, by displaying the alarm indicating the abnormality on the measurement result screen 500, the reliability of the data is improved, and the detection part (measurement item) of the abnormality is displayed, so that the subsequent user can easily deal with it. It becomes possible to do.

  In the example of FIG. 5, only Noise is shown in the display area (column 505) for displaying the alarm. The alarm displayed in this display area is the column 411 described in the third embodiment. The contents (alarm to be added) are displayed. In this case, when displaying the measurement result of the item Na (line 507), the alarm additional condition table (FIG. 4) for Na is used, and when displaying the measurement result of the item K (line 508), The alarm addition condition table for K is used, and the alarm addition condition table for Cl is used when displaying the measurement result of the item Cl (line 509).

  FIG. 6 shows an example of an alarm screen displayed on the monitor 26 (FIG. 1). In the example shown in FIG. 5, the measurement result, the alarm, and the detection site are displayed on one screen. In order to make the identification of the user easier, it is conceivable to display the measurement result and the alarm on separate screens. FIG. 6 shows an example of the alarm screen when the measurement result screen for displaying the measurement result and the alarm screen for displaying the alarm are displayed separately in this way. In this case, there is a separate measurement result screen showing the measurement result of each item.

  In FIG. 6, the measurement items in which the abnormality affecting the whole electrolyte measuring apparatus 100 detected in the first embodiment or the second embodiment is detected and the type of the abnormality are displayed on the alarm screen. In FIG. 6, measurement items and the like that have detected an abnormality that affects the whole are displayed together in a table. In FIG. 6, 602 is a column displaying the type of abnormality and the name of the measurement item in which the abnormality is detected, and 601 displays a code corresponding to the type displayed in the column 601 and the name of the measurement item. It is a column. Reference numeral 603 denotes a column that displays the detected abnormality level.

  In this example, the type of detected abnormality and the measurement item that detected the abnormality are displayed in a column 602. Although not particularly limited, the name of a measurement item that has detected an abnormality is displayed in parentheses. In the figure, the type of abnormality is a noise error, and “noise error (Na)” indicates that the abnormality is detected by a measurement item for measuring Na. In the code column 601, a code “001” corresponding to the noise error and a code “001” corresponding to the measurement item Na are displayed. In the level column 603, for example, an abnormal level is displayed. The level is divided into three levels, such as “report”, “caution”, and “warning”, corresponding to the importance of abnormality or the urgency of countermeasures. "Report" is displayed in the level column 603, and if the importance or urgency is high, "Warning" is displayed in the level column 603, and if the importance or urgency is intermediate, "Caution" is the level Column 603.

  The codes displayed in the column 601 may be determined and displayed so as to correspond to the types of abnormality and measurement items on a one-to-one basis. Moreover, what is necessary is just to determine a level according to the kind of abnormality, for example. In this case, for example, if the type of abnormality is noise, the level displayed in the level column 603 is “caution”, and if the type of abnormality is internal standard solution, the level displayed in the level column 603 is “warning”. And

  In this way, by using a screen different from the screen on which the measurement result is displayed, for example, the alarm screen (FIG. 6) displaying the details of the alarm can indicate the detected part of the abnormality, which can further enhance the discriminability. It becomes.

  Although the invention made by the inventor has been specifically described based on the above embodiment, the present invention is not limited to the above embodiment, and various modifications can be made without departing from the scope of the invention.

1 Sample Container 2 Sample Dispensing Nozzle 3 Dilution Tank 4-6 Ion Selective Electrode 7 Reference Electrode 8 Shipper Syringe 9 Internal Standard Solution Syringe 10 Diluent Syringe 11 Pinch Valve 12 Two-way Electromagnetic Valve for Reference Electrode 13 For Sipper Syringe Suction Two-way solenoid valve 14 Two-way solenoid valve for discharging waste liquid 15 Two-way solenoid valve for discharging internal standard liquid 16 Two-way solenoid valve for sucking internal standard liquid 17 Two-way solenoid valve for discharging diluted liquid 18 Two-way solenoid valve for sucking diluent 19 Reference Electrode Solution Bottle 20 Internal Standard Solution Bottle 21 Diluent Bottle 22 Amplifier 23 A / D Converter 24 Computer 25 Keyboard 26 Monitor 27 Memory

Claims (6)

A plurality of ion-selective electrodes respectively disposed in a flow path through which a sample and an internal standard solution selectively flow;
A control device that receives electromotive force generated in each of the plurality of ion selective electrodes, and obtains measurement results of a plurality of measurement items in the sample based on the electromotive force;
A display device for displaying the measurement results of the plurality of measurement items;
Comprising
When the control device detects that an electromotive force generated in the ion selective electrode is abnormal in one of the plurality of measurement items, the one measurement among the plurality of measurement items. An electrolyte measurement device that causes the display device to display that the measurement items other than the items are abnormal. In the electrolyte measuring device according to claim 1,
The measurement item to be measured in the electrolyte measurement device is requested from among the plurality of measurement items, and when the one measurement item is not requested, the control device performs an ion corresponding to the one measurement item. An electrolyte measurement device that detects whether or not an electromotive force generated in a selective electrode is abnormal, and when it is abnormal, displays on the display device that the requested measurement item is abnormal. In the electrolyte measuring device according to claim 1 or 2,
When the control device displays an abnormality on the display device, the electrolyte measurement device displays a measurement item in which the abnormality is detected. In the electrolyte measuring device according to claim 1 or 2,
The control device, when detecting an abnormality in two or more measurement items among the plurality of measurement items, when displaying the abnormality on the display device, a table for setting a priority order for the abnormality to be displayed An electrolyte measuring device. In the electrolyte measuring device according to claim 1,
Each of the plurality of measurement items is an electrolyte measurement device that is an item that specifies measurement corresponding to an electromotive force generated in each of the plurality of ion selective electrodes. In the electrolyte measuring device according to claim 5,
When the electromotive force generated in the ion-selective electrode corresponding to the one measurement item varies beyond a predetermined range or exceeds a predetermined value, the control device determines that the electromotive force is abnormal. Electrolyte measuring device to detect.

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