JP2015110549A - Composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a composition, a stabilizer and a stabilization method that improve the stability of astaxanthin compounds which are known to have useful effects, such as skin-whitening ability and aging prevention.SOLUTION: There is provided a composition containing: a component (A) that is an astaxanthin compound; and a component (B) that is a plant of a scientific name of Alpinia galanga (Zingiberaceae), or its extract. There is provided a stabilizer for astaxanthin compounds, the stabilizer containing a plant of a scientific name of Alpinia galanga (Zingiberaceae), or its extract, as an active ingredient.

Description

  The present invention relates to a composition comprising component (A) astaxanthins; component (B) Ginger family Namyangu plant or an extract thereof. The present invention also relates to an astaxanthin degradation inhibitor and method for inhibiting degradation, which uses a Gingaeaceae genus Nankyo plant or an extract thereof.

Astaxanthins are known to have functions such as an antioxidant effect, an anti-inflammatory effect (see Patent Literature 1 and Patent Literature 2), a skin aging prevention effect (see Patent Literature 3), and the like. For this reason, adding astaxanthins to foods, cosmetics, raw materials for pharmaceuticals, processed products thereof, and the like has been studied and implemented.
However, since astaxanthins are structurally unstable, it is difficult to contain them in a stable state by photolysis or component oxidation.
In order to stabilize astaxanthins, contrivances such as the combined use of astaxanthins and ascorbic acid have been made so far (see Patent Document 4).
Moreover, patent documents 5-7 are mentioned regarding astaxanthin.
In Patent Document 5, a. An oil-soluble plant extract containing astaxanthins extracted from the petals of Adonis Paraestina belonging to the genus Ranunculaceae, b. A dihydric alcohol having 4 to 8 carbon atoms; c. Polyphenols, d. An external preparation for skin containing a chelating agent is disclosed.
Patent Document 6 discloses that one or more of organic acids having two or more carboxyl groups (excluding citric acid), glycine, or salts thereof contain a carotenoid pigment or a carotenoid pigment. A method for stabilizing a carotenoid pigment added to a product is disclosed.
Patent Document 7 discloses the combined use of iron ions, iron chelating agents, dipropylene glycol, and water-soluble antioxidants.

However, astaxanthins are oil-soluble and unstable as described above, and it is difficult to suppress the effects of light and other components, so it is difficult to stabilize astaxanthins.
For example, when the stabilizer is a water-soluble component, astaxanthins are oil-soluble, so it is difficult to disperse the water-soluble stabilizer in the astaxanthins. Since the dispersion is not good, the effect of the stabilizer cannot be sufficiently exhibited.
For these reasons, it is desirable to stabilize astaxanthins known to have many useful effects.

JP-A-2-49091 Japanese Patent Laid-Open No. 9-143063 Japanese Patent Application Laid-Open No. 5-15536 JP-A-1-215263 JP 2010-105988 A JP-A-6-264055 JP 2012-31067 A

  The present invention is to provide a composition for enhancing the stability of astaxanthins known to have useful effects such as whitening and anti-aging, and a stabilizer and a stabilization method.

  As a result of intensive investigations in view of such circumstances, the present inventor has found that astaxanthins can be stabilized by using a Glyceraceae genus Nankyo plant or an extract thereof, and the present invention has been completed. It was. By combining the astaxanthins with the Ginger family genus Nankyo plant or an extract thereof, it is also possible to exert a remarkable effect on the prevention of discoloration and dispersibility of the astaxanthins by light. And by stabilizing astaxanthin suitably, the effects such as anti-aging effect and whitening effect of astaxanthin contained in cosmetics and the like can be remarkably enhanced, and as a result, such an effect of astaxanthin is improved. It is also possible to provide a composition in which is stabilized.

The present invention provides a composition comprising component (A) astaxanthins and component (B) Glyceraceae, or an extract thereof.
The present invention provides a cosmetic, an external preparation for skin, or a quasi-drug containing the composition.
This invention provides use of the said composition for manufacture of cosmetics, a skin external preparation, a quasi-drug, a pharmaceutical, food-drinks, or feed.
The present invention provides a stabilizer for astaxanthins comprising a ginger family genus Nankyo plant or an extract thereof as an active ingredient.
The present invention provides a method for stabilizing astaxanthins using a Glyceraceae genus Nankyo plant or an extract thereof.

  ADVANTAGE OF THE INVENTION According to this invention, the composition which improves the stability of astaxanthin known to have useful effects, such as whitening and anti-aging, a stabilizer, and a stabilization method can be provided.

The component (A) astaxanthin in the present technology is a kind of carotenoid, and unless otherwise specified, includes astaxanthin and astaxanthin derivatives such as astaxanthin esters. The astaxanthins can be selected from astaxanthin and astaxanthin derivatives.
In general, as an effect of astaxanthins, an antioxidant effect, an anti-inflammatory effect, an anti-skin aging effect, a whitening effect and the like are known. Astaxanthin is widely distributed in nature and is generally known to exist as an astaxanthin fatty acid ester, and also exist as an astaxanthin protein (oborbin, cluster cyanine) bound to a protein in crustaceans and the like. Usually, in the extraction of naturally-derived astaxanthin, the ratio of astaxanthin and an astaxanthin fatty acid ester is increased so that the above-described effects are suitably exhibited.

Furthermore, astaxanthin derivatives include astaxanthin salts, oxidized forms, reduced forms, geometrical isomers, optical isomers, glycosides, ester forms, and the like, as appropriate, in addition to naturally-derived astaxanthin esters.
More specific astaxanthin derivatives include, for example, amino acid esters such as glycine and alanine, carboxylic acid esters such as acetate ester and citrate ester and salts thereof; inorganic acid esters such as phosphate ester and sulfate ester and salts thereof; Glycosides such as glycosides; highly unsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid, unsaturated fatty acids such as oleic acid and linoleic acid, and fatty acid esters selected from saturated fatty acids such as palmitic acid and stearic acid Examples thereof include monoesters and the same or different diesters. Examples of the fatty acid include lower fatty acids having 2 to 4 carbon atoms, intermediate fatty acids having 5 to 12 carbon atoms, and higher fatty acids having 13 or more carbon atoms (for example, 16 to 22 carbon atoms).

Astaxanthin in the narrow sense is a red pigment having an absorption maximum at 476 nm (ethanol) and 468 nm (hexane), and its chemical structure is 3,3'-dihydroxy-β, β-carotene-4,4'-dione (C ₄₀ H ₅₂ 0 ₄ , molecular weight 596.82). This astaxanthin has 3S, 3S'-form, 3S, 3R'-form (meso-form), 3R, 3R'-form by the configuration of the 3 (3 ')-position hydroxyl groups in the ring structure at both ends of the molecule. There are three isomers of the body. There are also cis- and trans- isomers of conjugated double bonds at the center of the molecule. For example, all cis-, 9-cis and 13-cis isomers. Any one can be used in the present technology.

  Here, the hydroxyl group at the 3,3′-position can form an ester with a fatty acid. Astaxanthin obtained from krill is a diester form in which two fatty acids are linked, and those obtained from Haematococcus algae (H. pluvialis) are 3S and 3S'-forms, and many monoester forms in which one fatty acid is linked. Astaxanthin obtained from red yeast (Phaffia Rhodozyma) has a structure opposite to that of 3S, 3S'-form, which is usually found naturally in 3R, 3R'-form.

The component (A) astaxanthins of the present technology includes those extracted and purified from animals, plants, algae, bacteria and fungi. Moreover, it is not limited to the thing of natural origin, Any thing can be used if it is obtained according to a conventional method (organic synthetic product). It is also possible to use a mixture of these as appropriate. Naturally derived astaxanthin is derived from astaxanthin produced by a living organism.
Astaxanthins used in the present technology may be, for example, those extracted from natural products such as krill, salmon, trout, cypress, red yeast, Haematococcus algae, or synthetic products. In addition, for example, Katakura Chikkarin Co., Ltd., Marine Daio Co., Ltd., Swiss Pharmaceuticals, Takeda Shiki Co., Ltd., Fuji Chemical Industry Co., Ltd., Oriza Yuka Co., Ltd., Wako Pure Chemical Industries, Ltd., Biogenic General products commercially available from companies and the like can be used.
Among these, those extracted from Haematococcus alga (hereinafter also referred to as Haematococcus alga extract) are particularly preferable from the viewpoint of quality and productivity.
The extraction solvent for obtaining astaxanthins from natural products may be an aqueous solvent or an organic solvent.
As the organic solvent, alcohol (methanol, ethanol, isopropanol, acetone, 1,3-butylene glycol, ethylene glycol, propylene glycol, glycerin, etc.), ethyl acetate, ether, hexane, or the like can be used. Also, carbon dioxide in a supercritical state can be used. These solvents may be used alone or in combination of two or more.

  Specific examples of haematococcus algae extracts that can be used in the present technology include Haematococcus pluvialis, Haematococcus lacustris, Haematococcus capensis, and Haematococcus capensis Examples thereof include Haematococcus droebakensis and Haematococcus zimbabwiensis. Any commercially available Haematococcus alga extract can be used.

What is necessary is just to mix | blend using the product (for example, biological product) containing astaxanthin, when astaxanthins are included in the composition of this technique. At this time, the content of astaxanthins in the product used as the component (A) (astaxanthin-free body equivalent) is not particularly limited, but is preferably 0.01 to 50% by mass (hereinafter simply referred to as “%”). It is more preferably 0.1 to 30%, and particularly preferably 1 to 20%.
Moreover, the amount of astaxanthins in the composition of the present technology is preferably 0.0001 to 10%, more preferably 0.0001 to 1%, and still more preferably 0.001 to 0.1%. is there.

Ingredients in this technology (B) Zingiberaceae (Alpinia) Nankyo plant (hereinafter also referred to as “Nankyo plant”), the scientific name is called Alpinia galanga, also known as Thai ginger (English name: Thai ginger) ). The Nanko plant is widely used as a spice.
In addition, the use site of the above-mentioned Antarctic plant is not particularly limited, such as roots, rhizomes, stems, leaves, flowers, fruits and seeds, but the use of roots and / or rhizomes is preferable in terms of stabilizing astaxanthins, and rhizomes are more preferred. The plant is preferably used as it is or after being pulverized. Such a plant can be used as it is or as a squeezed juice obtained by squeezing it, a dried product obtained by drying the plant itself or a pulverized product thereof, or an extract extracted therefrom. Is preferred.

About the extraction method from the said Nanko plant, there is no restriction | limiting in particular, A general extraction method can be utilized.
The Nankyo extract is obtained by cutting at least one of whole grass, leaves, petals, seeds, roots, rhizomes, etc. without drying or drying, and then at a low temperature (for example, less than 4 ° C.) or a normal temperature (for example, 4 -40 ° C) and heating (for example, 40-100 ° C), and it is obtained by extraction with a solvent. In addition, it is desirable to use 50-1000 mL of solvent with respect to 100 g of the said Nankyo plant.

Moreover, as a solvent for extraction, water, an organic solvent, etc. are mentioned, for example.
Examples of the organic solvent include alcohols (monovalent, divalent or trivalent or higher alcohols), esters (ethyl acetate, butyl acetate, etc.), ketones (acetone, methyl ethyl ketone, etc.), ethers (diethyl ether, tetrahydrofuran, dipropyl ether). Etc.), hydrocarbons (hexane, benzene, pentane, etc.) and the like. Also, carbon dioxide in a supercritical state can be used.
As said monohydric alcohol, methanol, ethanol, isopropanol etc. are mentioned, for example. Examples of the dihydric alcohol include 1,3-butylene glycol, ethylene glycol, propylene glycol, and the like. Examples of the trihydric alcohol include glycerin. Examples of the trihydric or higher alcohol include sugar alcohols such as sorbitol and maltitol, polyethylene glycol, and the like. Among these, C1-C4 (preferably 2-3) lower alcohol is suitable.
Among organic solvents, a water-soluble organic solvent (for example, alcohol) is preferable because it can be used in combination with water.
From the viewpoint of use, water and / or a water-soluble organic solvent are preferable, and water, lower alcohol (more preferably, ethanol, methanol, 1,3-butylene glycol, etc.) or a mixed solvent thereof is preferable. .
From the illustrations of these extraction solvents, they may be used alone or in combination of two or more.

As an example of a preferable extraction method, the extraction is performed for 1 to 5 days using a lower alcohol (ethanol or 1,3-butylene glycol) having a content solvent concentration of 0 to 100% by volume. In addition, the density | concentration of a content machine solvent becomes like this. Preferably it is 30 volume% or more, More preferably, it is 50-100 volume%. Furthermore, it is preferable that it is low temperature or room temperature extraction (for example, 0-40 degreeC extraction).
As an example of a preferable extraction method, hot water extraction with water is preferably performed at a temperature condition of 60 ° C. or higher, more preferably 80 ° C. or higher. Extraction is preferably performed for 1 minute to 10 hours, more preferably for 10 minutes to 7 hours.

The extract of the above-mentioned Nanko plant with the above solvent may be in any form such as liquid, paste, gel, solid, and powder. The extract can be used as it is after preparation, but it may be used after being concentrated, dried or spray-dried and dissolved again in water or a polar solvent.
Furthermore, if necessary, it can be used after being subjected to treatments such as decolorization, deodorization, and desalting using filtration, activated carbon, ion exchange resin and the like within a range not affecting the effects of the present invention. Moreover, it can also fractionate and use by methods, such as ultrafiltration, ion-exchange chromatography, and gel filtration chromatography.

  The content (dry solid content) of the component (B) Nankyo plant or its extract of the present technology in the composition of the present technology is preferably 0.00001 to 1.0%, more preferably 0.0001 to 0.1%. And particularly preferably 0.001 to 0.01%.

The content ratio (dry solid content) in the composition of the present technology of the component (A) astaxanthins and the component (B) Nankyo plant or an extract thereof is not particularly limited, but for the stabilization effect of the astaxanthins ( The mass ratio of A) / (B) is preferably 0.1 to 50, more preferably 0.2 to 30.
The dose or coating amount of the component (A) astaxanthin is usually 0.01 to 10 mg (astaxanthin-free body equivalent), preferably 0.1 to 1 mg, and taken or divided into 1 to 3 times a day. It may be applied.

  In the composition of the present technology, components that are usually used in preparations such as cosmetics, quasi-drugs, and pharmaceuticals can be added to the composition of the present technology, as long as the effects of the present invention are not impaired. Examples of the component include water (purified water, hot spring water, deep water, etc.), oil agent, surfactant, metal soap, gelling agent, powder, alcohols, water-soluble polymer, film forming agent, resin, ultraviolet ray Protective agent, inclusion compound, antibacterial agent, fragrance, deodorant, salt, pH adjuster, refreshing agent, animal / microbe-derived extract, plant extract, blood circulation promoter, astringent, antiseborrheic agent, whitening agent , Anti-inflammatory agents, active oxygen scavengers, cell activators, moisturizers, chelating agents, keratolytic agents, enzymes, hormones, vitamins and the like.

The composition of the present technology can be obtained by a known production method. As a use of the composition of the present technology, it can be used for cosmetics, pharmaceuticals, foods and drinks, functional foods, external preparations for skin, quasi drugs, feeds and the like. The compositions of the present technology can be used to make them.
Moreover, as a form which mix | blends the composition of this technique, cosmetics, a quasi-drug, a pharmaceutical, food-drinks, functional foods (for example, supplement, food for specific health), animal feed etc. are mentioned, for example. It is done. When the composition of the present technology is blended in these forms, an appropriately acceptable component may be contained.
The present technology can be suitably used particularly for cosmetics and quasi drugs, and in this case, the component (A) and the component (B) are contacted or applied to the skin. Specific examples of cosmetics and quasi-drugs include, for example, basic cosmetics such as emulsions, creams, skin lotions, beauty liquids, packs, and cleaning agents, makeup cosmetics such as foundations, blushers, and lipsticks, and hair nourishing agents. , Hair tonics, shampoos, rinses and other hair cosmetics, dispersions, ointments, solutions, tablets, aerosols, patches, poultices, liniments, and the like.

Conventionally, astaxanthin has a useful effect as described above, but it is difficult to obtain the expected effect because of its structural instability, and it is difficult to maintain the effect over a long period of time.
In addition, since astaxanthins are oil-soluble, dispersibility in water is not good, so it is difficult to stabilize astaxanthins even if a water-soluble stabilizer is used, and it is difficult to obtain the expected effect.
However, as shown in the Examples below, the astaxanthin in the composition can be stabilized by blending the asperanthin or the extract thereof with the astaxanthin-containing composition. In blending, it is desirable to mix or stir the component (A) and the component (B).

By using the component (B) of the present technology, or an extract thereof, it is possible to improve the stability of astaxanthins, and thereby effectively demonstrate the efficacy of astaxanthins. For example, the Antarctic plant or its extract can exert a remarkable effect in preventing discoloration, inhibiting photolysis, and dispersing of astaxanthins.
And astaxanthins are useful for preventing and improving rough skin and wrinkles, preventing and improving spots, and further useful for preventing aging and whitening. Therefore, the above-mentioned Nankyo plant or its extract has these effects of astaxanthins. (For example, an anti-aging effect and a whitening effect) can be dramatically improved. By using the Nanko plant or an extract thereof, the effect of astaxanthins can be maintained over a longer period of time, or an equivalent or higher effect can be expected even if the content of astaxanthins is reduced.

Therefore, the composition containing the component (A) astaxanthin of the present technology and the component (B) Glyceraceae genus Nankyo plant or an extract thereof stably and stably exhibits the efficacy of the excellent astaxanthins as described above. It can be demonstrated.
Moreover, since the said Nanko plant of this technique or its extract has the stabilization effect | action of an astaxanthin, it can be used as an astaxanthin stabilizer used as an active ingredient by containing the said Nankyo plant or its extract. It is.
The said Nanko plant of this technique or its extract may be used for stabilization of astaxanthins, and can be used for various preparations for the purpose of stabilizing astaxanthins. It can also be used for manufacturing.
Therefore, the Nanko plant of the present technology or an extract thereof is used for the stabilization of astaxanthins, such as external preparations for skin, cosmetics, pharmaceuticals, quasi-drugs, foods and drinks, and functional foods (for example, foods for specified health use, supplements). Etc.).
Although the usage-amount (dry solid content) of the said Nankyo plant of this technique or its extract is not specifically limited, Preferably it is 0.01-1000 mass parts with respect to 1 mass part of astaxanthins, More preferably, it is 0.01. -500 mass parts. Especially preferably, it is 1-200 mass parts.

The present technology can also employ the following configurations.
[1] A composition comprising component (A) astaxanthins, and component (B) Glyceraceae, or an extract thereof.
[2] The composition according to the above [1], wherein the component (B) Nankyo plant is used in roots and / or rhizomes.
[3] The composition according to [1] or [2], wherein the extract of the component (B) Nankyo plant is water and / or a water-soluble organic solvent extract. The water-soluble organic solvent is preferably an alcohol.
[4] The composition according to any one of [1] to [3], which suppresses decomposition of the component (A) astaxanthins by light.
[5] A cosmetic, an external preparation for skin, or a quasi-drug containing the composition according to any one of [1] to [4].
[6] Use of the composition according to any one of [1] to [4] for the production of a cosmetic, an external preparation for skin, a quasi-drug, a pharmaceutical, a food or drink, or a feed.
[7] A stabilizer for astaxanthins comprising a ginger family Hanamyouga spp. Or an extract thereof as an active ingredient.
[8] A method for stabilizing astaxanthins using a Glyceraceae genus Nankyo plant or an extract thereof. The stabilization method, wherein the stabilization method suppresses decomposition of astaxanthins by light. It is preferable to contain 1 to 500 parts by mass of the Antarctic plant or an extract thereof with respect to 100 parts by mass of the astaxanthins.
[9] The stabilization method according to [8], wherein the photolysis of astaxanthins is suppressed.

[10] Use of the above-mentioned Antarctic plant or its extract for the production of an astaxanthin-containing composition or an astaxanthin stabilizer.
[11] Use of the Antarctic plant or an extract thereof as the astaxanthin-containing composition or astaxanthin stabilizer.
[12] Use of the Antarctic plant or an extract thereof for improving or sustaining the efficacy of the astaxanthins.
[13] A method for preventing, improving, or treating symptoms or diseases that can be prevented, ameliorated, or treated with astaxanthins, comprising ingesting or administering the composition containing the astaxanthins, and the Nankan plant or an extract thereof as an active ingredient. .

  EXAMPLES Hereinafter, although an Example etc. are given and this invention is demonstrated further more concretely, the scope of the present invention is not limited to these.

[Production Example 1: Production of Nankyo hot water extract 1]
100 g of rhododendron (scientific name: Alpinia galanga) was cut into pieces, 300 mL of water was added, extracted at 90 ° C. for 6 hours, filtered to remove insoluble matters, and Nankyo extract 1 was obtained. The dry solid content of this extract was 2.0%.

[Production Example 2: Production of Nankyo 50% ethanol extract 2]
100 g of rhododendron (scientific name: Alpinia galanga), minced with 300 mL of 50 volume% aqueous ethanol solution, extracted in a cool dark place (4-10 ° C.) for 2 days, filtered to remove insoluble matters, and extracted with 50% ethanol extract of Nankyo 2 was obtained. The dry solid content of this extract was 2.0%.

[Production Example 3: Production of Nankyo 90% ethanol extract 3]
100 g of rhododendron (scientific name: Alpinia galanga), minced with 300 mL of 90% ethanol by volume, extracted in a cool dark place (4-10 ° C) for 2 days, filtered to remove insolubles, and extracted with 90% ethanol 3 was obtained. The dry solid content of this extract was 2.3%.

Example 1
<Astaxanthin Photolysis Inhibition Effect (Stabilization Effect) Test 1>
Astaxanthin (manufactured by Wako Pure Chemical Industries, Ltd.) 0.00025% by mass, tri (capric acid / caprylic acid) glyceryl (manufactured by Nisshin Oilio Co., Ltd.) 0.00475% by mass, dimethyl sulfoxide 25% by mass, Production Examples 1 to 3 An aqueous solution containing the extract in a concentration of 0.001 to 0.05 mass% as a dry solid was prepared. 200 μL of each of these aqueous solutions was added to each 24-well plate, and the absorbance was measured. Then, each solution was irradiated with ultraviolet rays (UVA + B) for 5 minutes × 4 times, and the absorbance was measured after irradiation. Moreover, the solution which does not add a Nanko plant extract was made into control (0%). In addition, content of astaxanthins in [Example] is astaxanthin-free conversion.
Astaxanthin residual rate was measured by measuring the absorbance of each sample at 470 nm,
Astaxanthin residual rate (%) = ((A−B) / (C−D)) × 100 (Formula 1)
A = Absorbance of UV-irradiated astaxanthin-containing system B = Absorbance of UV-irradiated astaxanthin-free system C = Absorbance of UV-unirradiated astaxanthin-containing system D = Absorbance of non-UV-irradiated astaxanthin-containing system

The results are shown in Table 1. From this result, the Nanko plant extract was able to suitably prevent fading of astaxanthins under ultraviolet irradiation conditions. Astaxanthins are decomposed and discolored by ultraviolet rays, and the effect is reduced. This ultraviolet ray has a more chemical effect than sunlight. Therefore, the Nanko plant extract had an excellent effect on the photodegradation inhibition of astaxanthins. In addition, it was considered that the Nanko plant extract and the astaxanthins can be mixed suitably, and the Nankyo plant extract contributes to the improvement of dispersibility of the astaxanthins. Therefore, the Nanko plant extract can increase the stability of astaxanthins and maintain the effect over a long period of time.
As a comparative example, a commercially available antioxidant, tocotrienol (Tocolit 92; manufactured by Eisai Food Chemical Co., Ltd.) was added at a concentration of 0.0001 mM, and the same test was performed. The result was 19.1%.

Example 2 [Formulation in lotion]
(Ingredient) (%)
1 Glycerin 5.0
2 1,3-butylene glycol 5.0
3 Lactic acid 0.05
4 Sodium lactate 0.1
5 Polyoxyethylene (20E.O.) sorbitan monooleate 1.2
6 Ethanol 8.0
7 Nankyo extract 1 0.05
8 Oil containing 5% astaxanthin (Note 1) 0.001
9 Methyl paraoxybenzoate 0.1
10 Fragrance 0.05
11 Purified water Remaining (Note 1) Astaxanthin derived from Haematococcus algae

(Production method)
A: Components (5) to (10) are mixed and dissolved.
B: Components (1) to (4) and (11) are mixed and dissolved.
C: A was added to B and mixed to obtain a skin lotion.

Example 3 [Formulation in emulsion]
(Ingredient) (%)
1 Polyoxyethylene monostearate (20E.O.) sorbitan 1.0
2 Polyoxyethylene trioleate (20E.O.) sorbitan 0.5
3 Glyceryl monostearate 1.0
4 Stearic acid 0.5
5 Behenyl alcohol 0.5
6 Squalane 8.0
7 Carboxyvinyl polymer 0.1
8 Methyl paraoxybenzoate 0.1
9 Sodium hydroxide 0.05
10 Purified water remaining 11 Ethanol 5.0
12 Nankyo extract 2 0.01
13 Oil containing 1% astaxanthin (Note 2) 0.01
14 Fragrance 0.05
(Note 2) Astaxanthin from Adonis Palestine flowers

(Production method)
A: Components (1) to (6) are uniformly mixed at 70 ° C.
B: Components (7) to (10) are uniformly mixed at 70 ° C. C: A is added to B, emulsified, and cooled to room temperature.
D: (11) to (14) were added to C and mixed uniformly to obtain an emulsion.

Example 4 [Formulation in liquid foundation (oil-in-water cream)]
(Ingredient) (%)
1 1,3 Butylene glycol 5.0
2 Hydrogenated soybean phospholipid 0.5
3 Titanium oxide 5.0
4 Bengala 0.1
5 Yellow iron oxide 1.0
6 Black iron oxide 0.05
7 Acrylic acid / alkyl methacrylate copolymer (Note 3) 0.5
8 Triethanolamine 1.5
9 Purified water remaining 10 Glycerin 5.0
11 Ethyl paraoxybenzoate 0.1
12 Stearic acid 0.9
13 Glycerol monostearate 0.3
14 cetostearyl alcohol 0.4
15 Polyoxyethylene (20E.O.) sorbitan monooleate 0.2
16 Polyoxyethylene trioleate (20E.O.) sorbitan 0.2
17 2-Ethylhexyl paramethoxycinnamate 5.0
18 Nankyo extract 3 0.05
19 Oil containing 5% astaxanthin (Note 4) 0.05
20 Perfume 0.02
(Note 3) Pemulen TR-2 (manufactured by NOVEON)
(Note 4) Astaxanthin derived from Hematococcus spurbiaris

(Production method)
A: Disperse components (1) to (6).
B: Components (7) to (11) are added to A and mixed uniformly at 70 ° C.
C: Components (12) to (17) are uniformly mixed at 70 ° C.
D: B is added to C to emulsify, and cooled to room temperature.
E: Components (18) to (20) were added to D to obtain an oil-in-water cream liquid foundation.

Example 5 [Formulation in sunscreen cosmetic (water-in-oil cream)]
(Ingredient) (%)
1 Polyoxyethylene (20E.O.) sorbitan monolaurate 0.2
2 Polyoxyethylene (60) hydrogenated castor oil 0.1
3 Remaining purified water 4 Dipropylene glycol 10.0
5 Magnesium sulfate 0.5
6 Ascorbic acid glucoside 2.0
7 PEG-9 Polydimethylsiloxyethyl dimethicone 3.0
8 Decamethylcyclopentasiloxane 20.0
9 Isotridecyl isononanoate 5.0
10 2-Ethylhexyl paramethoxycinnamate 8.0
11 Nankyo extract 1 0.3
12 Oil containing 2% astaxanthin (Note 5) 0.01
13 Dimethylstearyl ammonium hectorite 1.2
(Note 5) Astaxanthin derived from Haematococcus algae

(Production method)
A: Components (1) to (6) are uniformly dispersed.
B: Components (7) to (13) are uniformly dispersed.
C: While stirring B, A was gradually added to emulsify to obtain a water-in-oil cream sunscreen cosmetic.

Example 6 [Formulation in ointment]
(Ingredient) (%)
1 Triethanolamine 2.0
2 Glycerin 5.0
3 Dipotassium glycyrrhizinate 0.5
4 Remaining amount of purified water 5 Stearic acid 18.0
6 Cetanol 4.0
7 Nankyo extract 2 0.05
8 Oil containing 20% astaxanthin (Note 6) 0.01
9 dl-α-tocopherol acetate 0.2
10 Methyl paraoxybenzoate 0.1
(Note 6) Astaxanthin derived from Haematococcus algae

(Production method)
A: Components (1) to (4) are uniformly dissolved and kept at 75 ° C.
B: Components (5) to (10) are heated and mixed and kept at 75 ° C.
C: B was gradually added to A to obtain an ointment.

Example 7 [Formulation in lotion preparation]
(Ingredient) (%)
1 Polyoxyethylene (20E.O.) sorbitan monolaurate
1.2
2 Ethanol 8.0
3 Nankyo extract 3 0.05
4 Oil containing 5% astaxanthin (Note 7) 0.001
5 Methyl paraoxybenzoate 0.2
6 Glycerin 5.0
7 1,3-butylene glycol 6.5
8 Purified water remaining amount (Note 7) Astaxanthin

(Production method)
A: Components (1) to (5) are mixed and dissolved.
B: Components (6) to (8) are mixed and dissolved.
C: A and B were mixed to make a lotion agent.

Example 8 [Formulation in lip balm]
(Ingredient) (%)
1 Candelilla wax 4.0
2 Ethylene / propylene copolymer 10.0
3 Pentaerythritol rosinate 5.0
4 Cetyl 2-ethylhexanoate 22.0
5 Vaseline 10.0
6 Acetic acid liquid lanolin 15.0
7 Diisostearyl malate 25.0
8 Diglyceryl triisostearate 9 Vitamin E 0.5
10 1,3-butylene glycol 1.0
11 Smoke-like silicic acid 1.0
12 Nankyo extract 1 0.05
13 Oil containing 5% astaxanthin (Note 8) 0.3
13 Phenoxyethanol 0.3
14 Dibutylhydroxytoluene 0.1
(Note 8) Krill-derived astaxanthin

(Production method)
A: Components (1) to (9) are uniformly dissolved and mixed at 100 ° C.
B: (10), (11) and (12) are added and mixed uniformly.
C: B, (13) and (14) are added to A and mixed and dispersed.
D: After defoaming C, the container was filled and cooled to obtain a lip balm.

  A composition comprising the astaxanthin of the present technology and the ginger family Namyoga spp. Or an extract thereof, and a stabilizer and a stabilization method of astaxanthins using the sputum plant or the extract thereof, The efficacy of astaxanthins can be improved. For example, it is useful for exerting effects on the skin such as prevention of aging and prevention / improvement of spots. In addition, since the Nanko plant is used as a spice, it is highly safe. Therefore, cosmetics, external preparations for skin, medicines, foods and drinks and feeds containing the Nanko plant or its extract should be expected to be highly safe. Can do.

Claims (9)

Component (A) astaxanthins, and
Ingredient (B) A composition containing Gingaeaceae genus Nankyo plant or an extract thereof.   The composition according to claim 1, wherein the use site of the component (B) Nankyo plant is a root and / or rhizome.   The composition according to claim 1 or 2, wherein the extract of the component (B) Antarctic plant is water and / or a water-soluble organic solvent extract.   The composition of any one of Claims 1-3 which suppresses decomposition | disassembly of the said component (A) astaxanthin by light.   Cosmetics, a skin external preparation, or a quasi-drug containing the composition of any one of Claims 1-4.   Use of the composition according to any one of claims 1 to 4 for the production of a cosmetic, an external preparation for skin, a quasi-drug, a pharmaceutical, a food or drink, or a feed.   A stabilizer for astaxanthins comprising an active ingredient of the ginger family Hanamyoga spp. Or an extract thereof.   A method for stabilizing astaxanthins using a Ginkgoaceae genus Nankyo plant or an extract thereof.   The stabilization method of Claim 8 which suppresses photolysis of astaxanthin.