JP2014018508A - Automatic nerve control device and renal sympathetic nerve control device - Google Patents

Abstract

The present invention provides an autonomic nerve control device and a renal sympathetic nerve control device that can effectively treat hypertension and the like while maintaining the nerve without risk of complications.
A cooling means 11 is configured to be embedded in a user's body so as to cool a nerve bundle 1 of a renal sympathetic nerve. The cooling means 11 has a Peltier element 21, and can cool the outer surface of the nerve bundle 1, with the heat absorption side surface of the Peltier element 21 facing the nerve bundle 1, and at least the nerve bundle 1 along the outer periphery of the nerve bundle 1. It is configured to surround a part. The cooling means 11 is configured to be able to conduct heat released from the heat radiation side surface of the Peltier element 21 to the abdominal aorta 2, the renal artery 3 or the ureter 4 passing through the vicinity of the nerve bundle 1, or the peritoneum. Yes. The driving means 12 is configured to drive the cooling means 11 so as to reduce renal sympathetic nerve activity by cooling the nerve bundle 1.
[Selection] Figure 2

Description

  The present invention relates to an autonomic nerve control device and a renal sympathetic nerve control device.

  Conventionally, for the treatment of hypertension, life guidance such as salt restriction and weight loss and medical treatment have been performed. However, drug treatment often has to last for a lifetime, and the burden on the patient is large, and the burden of medical expenses is enormous in the national economy. In addition, about 10% of hypertensive patients (about 3 million) are drug-resistant hypertensive patients that are difficult to treat with drugs. Even if three or four drugs are combined, it is difficult to control blood pressure. There are very many cases.

  Therefore, as an alternative to drug therapy, or as a therapy for drug-resistant hypertension, if appropriate, surgery for adrenal tumors, sympathetic nerve cutting, catheter surgery (for example, patents) Reference 1), ablation treatment of renal sympathetic nerve via renal artery (for example, see Non-Patent Document 1) and the like have been devised. If hypertension is left unattended, fatal complications such as stroke, ischemic heart disease such as angina pectoris and myocardial infarction, dissecting aortic aneurysm, renal dysfunction, and cardiovascular events such as heart failure may occur. (For example, refer nonpatent literature 2).

Special table 2011-505963

Hidekatsu Fukuda and Genjiro Kimura, “The Forefront of Medicine and Medical Treatment, Cardiovascular Disease Treatment by Renal Artery Sympathetic Ablation (Commentary)”, Journal of Japan Society for Internal Medicine, August 2011, Vol. 100, No. 8, p.2289 -2294 Toshihiko Ishimitsu, Reiko Abe, Hideki Yano, “Latest Evidence and Guidelines for Hypertension Treatment (Commentary / Special Feature)”, Medical Science Digest, June 2011, Vol. 37, No. 6, p.222-225

  Surgical treatments such as adrenal tumor surgery, sympathetic nerve amputation for hypertension patients, catheter surgery described in Patent Document 1, and renal sympathetic nerve ablation described in Non-Patent Document 1 have no problems with the adrenal gland. In some cases, it was impossible to adapt and there was a problem that there was a risk of complications. In addition, the ablation treatment of the renal sympathetic nerve described in Non-Patent Document 1 is not a medically established operation and is not performed in Japan. In addition, when a patient becomes septic shock due to bacteremia after ablation, sodium reabsorption is inhibited and cannot be recovered from the shock. Therefore, in order to maintain homeostasis of the human body, a treatment method different from an irreversible method of removing nerves such as renal sympathetic nerve ablation treatment is desired.

  The present invention has been made paying attention to such problems, and there is no risk of complications, and an autonomic nerve control device and renal sympathy that can effectively treat hypertension or the like while maintaining nerves. An object is to provide a neural control device.

  An autonomic nerve control device according to the present invention includes a temperature control unit embedded in a user's body so as to control the temperature of a sympathetic nerve or parasympathetic nerve bundle that is an autonomic nerve, and a drive that drives the temperature control unit Means.

  The autonomic nerve control device according to the present invention can be widely used for sympathetic nerve bundles and parasympathetic nerve bundles, and can treat autonomic nerve function diseases. The autonomic nerve control device according to the present invention can cool the nerve bundle and reduce the autonomic nerve activity by heating the nerve bundle, or activate the autonomic nerve activity by heating the nerve bundle, such as hypertension. Therapeutic effects on various pathological conditions involving autonomic nervous activity can be obtained.

  The autonomic nerve control device according to the present invention is implantable and reversible temperature control is possible, and the temperature control is performed only when a symptom appears, thereby reducing the load on the patient. Also, unlike those that remove nerves, treatment is performed with the nerves preserved, so there is no risk of complications and it is safe. In addition, the autonomic nervous function of the human body can be maintained.

  The autonomic nervous control device according to the present invention can reduce the burden on the user of the user because it is not necessary to take medicine or can significantly reduce the medicine once an implantation operation is performed. Can do. In addition, a huge medical cost reduction effect can be obtained even in the national medical finance in Japan, where drug costs are large, and a large medical economic reduction effect can be expected worldwide.

  The renal sympathetic nerve control device according to the present invention has the autonomic nerve control device according to the present invention, and the temperature control means is a cooling means embedded in a user's body so as to cool the nerve sympathetic nerve bundle. The drive means is configured to drive the cooling means so as to reduce renal sympathetic nerve activity by cooling the nerve bundle.

  The renal sympathetic nerve control device according to the present invention can drive the cooling means by the driving means, cool the nerve bundle of the user's renal sympathetic nerve by the cooling means, and reduce the renal sympathetic nerve activity. For this reason, by cooling the renal sympathetic nerve when the blood pressure is high, the blood pressure can be lowered by relaxing the tension of the renal artery and dilating the blood vessels. Thus, the renal sympathetic nerve control device according to the present invention can effectively treat hypertension.

  Since the renal sympathetic nerve control device according to the present invention can effectively treat essential hypertension accompanied by abnormal blood pressure reflex function, it contributes to the health and longevity of the user by suppressing the occurrence of cardiovascular events. be able to. In addition, it has been widely reported that a therapeutic effect can be obtained by blocking autonomic nerves in the pathology of heart failure, and a therapeutic effect on heart failure can also be expected. Even in the pathology of renal failure, prerenal renal failure is due to stenosis of the renal arteries, so that the renal function can be improved by autonomic nerve control by the renal sympathetic nerve control device according to the present invention, and the therapeutic effect on renal failure is also achieved. I can expect. For this reason, the renal sympathetic nerve control device according to the present invention is a great gospel even for patients with heart failure and renal failure.

  As described above, the renal sympathetic nerve control device according to the present invention is completely implantable and can treat the renal sympathetic nerve by temporarily cooling the renal sympathetic nerve with a cooling device for a pathological condition such as hypertension, heart failure, or renal failure. It provides a completely new treatment that can be given, and can provide a new treatment option for patients with severe hypertension that cannot be treated even after taking several kinds of drugs.

  In the renal sympathetic nerve control device according to the present invention, the cooling means may be configured to surround at least a part of the nerve bundle along the outer periphery of the nerve bundle so that the outer surface of the nerve bundle can be cooled. preferable. In this case, the nerve bundle of the renal sympathetic nerve can be effectively cooled, and the therapeutic effect can be enhanced.

  In the renal sympathetic nerve control device according to the present invention, the cooling means includes a Peltier element, and the heat dissipation side surface of the Peltier element has a larger area than the heat absorption side surface, and the heat absorption side surface is defined as the nerve bundle. It is preferable that it can arrange | position toward. In this case, it is possible to reduce the size of the cooling means by using the Peltier element, and to reduce the burden on the user. Also, by increasing the surface on the heat dissipation side, the heat dissipation efficiency of heat generated with cooling can be increased. Thereby, while suppressing the influence on the user's human body by a heat | fever, the cooling efficiency by a Peltier device can be improved.

  In the renal sympathetic nerve control device according to the present invention, the cooling means has a Peltier element, and the heat absorption side surface of the Peltier element can be arranged facing the nerve bundle, and the heat released from the heat dissipation side surface May be configured to be able to conduct to the artery or ureter passing through the vicinity of the nerve bundle, or the peritoneum. In this case, the heat generated by cooling can be quickly diffused and discharged using arterial blood circulation, urine discharge, and blood circulation in the peritoneum where blood flow is abundant. The influence on the human body can be suppressed.

  In the renal sympathetic nerve control device according to the present invention, the temperature control means includes a heating means embedded in a user's body so that the nerve sympathetic nerve bundle can be heated, and the driving means includes the nerve bundle. The heating means may be driven so as to activate autonomic nerve activity by heating. In this case, not only can the autonomic nerve activity be reduced by the cooling means, but also the autonomic nerve activity can be activated by the heating means. For this reason, the fall and rise of blood pressure can be finely controlled. The heating means has a Peltier element, the heat dissipation side of the Peltier element is placed facing the nerve bundle, and the low temperature of the heat absorption side can be conducted to the artery or ureter passing through the vicinity of the nerve bundle, or the peritoneum It may be. In this case, the low temperature of the endothermic surface can be quickly diffused and discharged, and the influence of the low temperature on the user's human body can be suppressed.

  In the renal sympathetic nerve control device according to the present invention, the driving means controls a battery disposed in the user's body so that the temperature control means can be driven, and ON / OFF of the battery from outside the user's body. Or a secondary coil disposed inside the user's body so as to be able to supply energy to the temperature control means, and disposed outside the user's body so that the secondary coil is not connected to the secondary coil. It preferably comprises a transcutaneous energy transmission system having a primary coil capable of supplying energy destructively. In this case, the temperature of the nerve bundle of the renal sympathetic nerve can be controlled from outside the user's body. For this reason, for example, when the blood pressure is high, when heart failure occurs, or when renal failure occurs, the user himself / herself makes a judgment, turns on the battery switch, or removes the primary coil from outside the body. Or the like, the embedded cooling means can be operated to cool the nerve sympathetic nerve bundle. In this way, it is possible to treat hypertension, heart failure, renal failure, etc. noninvasively at the user's own discretion only when necessary.

  The renal sympathetic nerve control device according to the present invention controls the driving means and a sensor that acquires data relating to blood flow including the user's blood pressure and / or data relating to the user's autonomic nerve activity. And a control unit provided to be able to control the renal sympathetic nerve activity so that the data acquired by the sensor approaches the value of a healthy person. In this case, the renal sympathetic nerve activity is automatically controlled based on the data of the automatic blood pressure monitor, the data of the autonomic nerve activity record obtained by the electrode directly in contact with the sympathetic nerve or the parasympathetic nerve bundle, etc. Can treat renal failure, heart failure, etc.

  According to the present invention, it is possible to provide an autonomic nerve control device and a renal sympathetic nerve control device that can effectively treat hypertension and the like while maintaining nerves without risk of complications.

It is a perspective view which shows the renal sympathetic nerve control apparatus of embodiment of this invention. It is a perspective view which shows the use condition of the renal sympathetic nerve control apparatus shown in FIG. (A) ECG (ECG), (b) Aortic pressure (AOP), (c) Left atrial pressure (LAP), (d) Integrated renal sympathetic nerve activity showing an example of time-series recording of renal sympathetic nerve activity It is a graph of a waveform (integrated Neurogram), (e) a renal sympathetic nerve activity waveform (Neurogram). It is a graph of the renal sympathetic nerve activity waveform after cooling of (a) renal sympathetic nerve by the renal sympathetic nerve control apparatus shown in FIG.

Hereinafter, embodiments of the present invention will be described with reference to the drawings.
1 to 4 show an autonomic nerve control device and a renal sympathetic nerve control device according to an embodiment of the present invention. The renal sympathetic nerve control device according to the embodiment of the present invention is configured to be able to control the temperature of the nerve bundle of the renal sympathetic nerve among the autonomic nerve control device according to the embodiment of the present invention.
As shown in FIGS. 1 and 2, the renal sympathetic nerve control apparatus 10 includes a cooling unit 11 and a driving unit 12.

  As shown in FIG. 1, the cooling means 11 is attached in contact with the rectangular plate-shaped Peltier element 21, the cooling unit 22 attached in contact with the heat absorption surface of the Peltier element 21, and the heat dissipation surface of the Peltier element 21. And a heating unit 23. The cooling means 11 is formed so that the cross-sectional shape of the Peltier element 21 in the width direction maintains the same shape along the length direction of the Peltier element 21. The cooling unit 22 has a cross-sectional shape in the width direction of the Peltier element 21 that has a triangular shape with the endothermic surface of the Beltier element as a base, and extends along the length direction of the Peltier element 21 from the center to the apex of the triangle. A cylindrical nerve bundle groove 24 is provided. The nerve bundle groove 24 has an arc-shaped cross section longer than a semicircle, and is open on the apex side opposite to the Peltier element 21. In the cooling unit 22, the inner surface of the nerve bundle groove 24 is a cooling surface 25.

  In the heating unit 23, the cross-sectional shape of the Peltier element 21 in the width direction has a rectangular shape with the heat dissipation surface of the Beltier element as one side, and the Peltier element 21 extends from the center of the rectangle to the side opposite to the Beltier element. It has a cylindrical arterial groove 26 extending along the length direction. The arterial groove 26 has an arc-shaped cross section longer than a semicircle, and is open on the side opposite to the Peltier element 21. The arterial groove 26 has a larger diameter than the nerve bundle groove 24. In the heating unit 23, the inner surface of the arterial groove 26 is a heating surface 27, and the heating surface 27 has a larger area than the cooling surface 25.

  As shown in FIG. 2, the cooling means 11 is embedded in the user's body so that the nerve bundle 1 of the renal sympathetic nerve can be cooled. The cooling means 11 is disposed so as to surround the nerve bundle 1 along the outer periphery of the nerve bundle 1 by inserting the nerve bundle 1 into the nerve bundle groove 24 of the cooling unit 22. Thereby, the cooling means 11 can cool the outer surface of the nerve bundle 1. The cooling means 11 is disposed by inserting the abdominal aorta 2 and the renal artery 3 passing through the vicinity of the nerve bundle 1 into the arterial groove 26 of the heating unit 23. Thereby, the cooling means 11 can conduct heat released from the heating surface 27 to the abdominal aorta 2 and the renal artery 3.

  As shown in FIG. 1, the driving means 12 is composed of a transcutaneous energy transmission system, and has a primary coil 28 and a secondary coil 29. The secondary coil 29 is connected to the cooling means 11 so that energy can be supplied to the cooling means 11. The secondary coil 29 is arranged in the user's body together with the cooling means 11. The primary coil 28 is arranged outside the user's body and is configured to be able to supply energy to the secondary coil 29 in a non-destructive manner.

Next, the operation will be described.
The renal sympathetic nerve control apparatus 10 is used by embedding the cooling means 11 and the secondary coil 29 in a user's body in order to mainly treat hypertension. For embedding, first, as shown in FIG. 2, the retroperitoneum is carefully peeled to expose the renal artery 3 in the vicinity of the kidney 4, and the cooling means 11 and the secondary coil 29 are disposed around the renal sympathetic nerve going there. And place. At this time, the nerve bundle 1 is inserted into the nerve bundle groove 24 of the cooling unit 22, and the abdominal aorta 2 and the renal artery 3 passing through the vicinity of the nerve bundle 1 are inserted into the artery groove 26 of the heating unit 23. To do. Thereafter, sutures are performed for each layer, and the implantation operation is completed.

  The renal sympathetic nerve control device 10 drives the cooling means 11 by the driving means 12 and can cool the nerve bundle 1 of the user's renal sympathetic nerve while maintaining the function by the cooling means 11. Can reduce activity. For this reason, when the blood pressure is high, the renal sympathetic nerve is cooled, thereby relaxing the tension of the renal artery 3 to expand the blood vessels, improving the renal function, increasing the urine volume, and lowering the blood pressure. Thus, the renal sympathetic nerve control device 10 can effectively treat hypertension.

  Since the renal sympathetic nerve control device 10 can effectively treat essential hypertension accompanied by abnormal blood pressure reflex function, it can contribute to the health and longevity of the user by suppressing the occurrence of cardiovascular events. . In addition, it has been widely reported that a therapeutic effect can be obtained by blocking autonomic nerves in the pathology of heart failure, and a therapeutic effect on heart failure can also be expected. Even in the pathological state of renal failure, prerenal renal failure is due to stenosis of the renal artery, so that the renal function can be improved by autonomic nerve control by the renal sympathetic nerve control device 10, and a therapeutic effect on renal failure can also be expected. For this reason, the renal sympathetic nerve control device 10 is a great gospel even for patients with heart failure and renal failure.

  Thus, the renal sympathetic nerve control device 10 is completely implantable and can treat the renal sympathetic nerve by temporarily cooling the renal sympathetic nerve with the cooling means 11 for pathological conditions such as hypertension, heart failure, and renal failure. It provides a new treatment and can provide a new treatment option for patients with severe hypertension that cannot be treated by taking several kinds of drugs.

  The renal sympathetic nerve control device 10 is an implantable and reversible temperature control, and the temperature is controlled only when a symptom appears, thereby reducing the load on the patient. Also, unlike those that remove nerves, treatment is performed with the nerves preserved, so there is no risk of complications and it is safe. In addition, the autonomic nervous function of the human body can be maintained.

  The renal sympathetic nerve control device 10 can reduce the user's economic burden because it is not necessary to take medicine or can significantly reduce the medicine once an implantation operation is performed. . In addition, a huge medical cost reduction effect can be obtained even in the national medical finance in Japan, where drug costs are large, and a large medical economic reduction effect can be expected worldwide.

  Since the renal sympathetic nerve control device 10 uses the Peltier element 21, the cooling means 11 can be reduced in size, and the burden on the user can be reduced. The Peltier element 21 is a heat transport electronic element, and heat is transferred from the heat absorption surface to the heat dissipation surface. Therefore, at the same time as the renal sympathetic nerve is cooled, heat is transported to the heating unit 23 on the opposite side. For this reason, by increasing the heating surface 27, it is possible to increase the heat dissipation efficiency of the heat generated with the cooling. In addition, by conducting heat from the heating surface 27 to the abdominal aorta 2 and the renal artery 3, heat generated with cooling can be quickly diffused and discharged using the blood circulation of the artery. Thereby, while suppressing the influence on the user's human body by a heat | fever, the cooling efficiency by the Peltier device 21 can be improved.

  In the renal sympathetic nerve control device 10, the driving means 12 is composed of a transcutaneous energy transmission system, and by simply bringing the primary coil 28 into contact with the skin from outside the body, the embedded cooling means 11 is operated to activate the nerve sympathetic nerve bundle. 1 can be cooled. For example, when the blood pressure is high, when heart failure occurs, or when kidney failure occurs, the user himself / herself makes a judgment and makes the cooling means 11 contact the skin from the primary coil 28 from outside the body. The nerve bundle 1 of the renal sympathetic nerve can be cooled by operating. In this way, it is possible to treat hypertension, heart failure, renal failure, etc. noninvasively at the user's own discretion only when necessary.

  The driving means 12 may be composed of a system having a battery disposed inside the user's body so that the cooling means 11 can be driven, and a switch capable of controlling ON / OFF of the battery from outside the user's body. . Also in this case, by simply turning on the battery switch, the embedded cooling means 11 can be operated to cool the nerve sympathetic nerve bundle 1 of the renal sympathetic nerve, and the user's own judgment can be made only when necessary. Thus, high blood pressure, heart failure, renal failure, etc. can be treated non-invasively.

  Further, the renal sympathetic nerve control device 10 inserts the ureter 5 passing through the vicinity of the nerve bundle 1 into the arterial groove 26 of the heating unit 23 or brings the heating unit 23 into contact with the peritoneum. The heat released from the heating unit 23 may be conducted to the ureter 5 or the peritoneum. In this case, the heat generated by cooling can be quickly diffused and discharged using the discharge of urine and blood circulation in the peritoneum where blood flow is abundant. Can be suppressed.

  The renal sympathetic nerve control device 10 has a heating means embedded in the user's body so that the nerve sympathetic nerve bundle 1 can be heated, and the driving means 12 autonomously heats the nerve bundle 1. The heating means may be driven so as to activate the nerve activity. In this case, not only can the autonomic nerve activity be reduced by the cooling means 11, but also the autonomic nerve activity can be activated by the heating means. For this reason, the fall and rise of blood pressure can be finely controlled. The heating means has a Peltier element 21, disposes the heat dissipation surface of the Peltier element 21 toward the nerve bundle 1, and sets the low temperature of the heat absorption surface to the abdominal aorta 2, renal artery 3 or ureter that passes near the nerve bundle 1. 5, or may be conductive to the peritoneum.

  In addition, the renal sympathetic nerve control device 10 controls the driving means 12 with a sensor that acquires data on blood flow including the blood pressure of the user and / or data on the autonomic nerve activity of the user. You may have the control part provided so that the acquired data may control a renal sympathetic nerve activity so that the value of a healthy person may approach. In this case, as shown in the time-series recording of renal sympathetic nerve activity in FIG. 3, the data of the automatic blood pressure monitor, the data of the autonomic nerve activity record obtained by the electrode directly in contact with the sympathetic nerve or the parasympathetic nerve bundle, etc. Based on this, the renal sympathetic nerve activity can be automatically controlled by the automatic control algorithm of the control unit to treat hypertension, renal failure, heart failure and the like. Data on renal sympathetic nerve activity can also be obtained from, for example, heart rate variability and calf nerves.

  The renal sympathetic nerve control device 10 may be used not only as a renal sympathetic nerve but also as an autonomic nerve control device capable of controlling the temperature of a nerve bundle of other sympathetic nerves or parasympathetic nerves. In this case, it can be widely used for sympathetic nerve bundles and parasympathetic nerve bundles, and autonomic nerve function diseases can be treated. In addition, by cooling the nerve bundle to reduce the autonomic nerve activity, or heating the nerve bundle to activate the autonomic nerve activity, it is possible to obtain therapeutic effects on various pathological conditions involving the autonomic nerve activity .

  The renal sympathetic nerve control device 10 was attached to the goat, and the renal sympathetic nerve of the goat was cooled from 36 ° C. to 26 ° C. in a short time (instant). The renal sympathetic nerve activity waveforms before and after cooling are shown in FIGS. 4 (a) and 4 (b), respectively. It should be noted that the temperature of the renal sympathetic nerve has recovered in about 3 minutes after the end of cooling.

  As shown in FIGS. 4A and 4B, after cooling, the amplitude of the renal sympathetic nerve activity waveform is smaller than that before cooling, and the sympathetic nerve activity is suppressed by cooling the renal sympathetic nerve. It can be confirmed. In this way, by cooling the renal sympathetic nerve with the renal sympathetic nerve control device 10, it is possible to relax the tension of the renal artery 3 to dilate the blood vessels and lower the blood pressure, thereby effectively treating hypertension and the like. It can be said that it is possible.

DESCRIPTION OF SYMBOLS 1 Nerve bundle 2 Abdominal aorta 3 Renal artery 4 Kidney 5 Ureteral 10 Renal sympathetic nerve control apparatus 11 Cooling means 21 Peltier element 22 Cooling part 23 Heating part 24 Nerve bundle groove 25 Cooling surface 26 Arterial groove 27 Heating face 12 Driving means 28 Primary coil 29 Secondary coil

Claims (8)

A temperature control means embedded in the user's body so that the temperature of the sympathetic nerve or parasympathetic nerve bundle that is an autonomic nerve can be controlled;
Driving means for driving the temperature control means;
An autonomic nerve control device comprising: The autonomic nerve control device according to claim 1,
The temperature control means has cooling means embedded in the user's body so that the nerve sympathetic nerve bundle can be cooled.
The renal sympathetic nerve control apparatus, wherein the driving means is configured to drive the cooling means so as to reduce renal sympathetic nerve activity by cooling the nerve bundle.   The renal sympathetic nerve according to claim 2, wherein the cooling means is configured to surround at least a part of the nerve bundle along the outer periphery of the nerve bundle so that the outer surface of the nerve bundle can be cooled. Control device.   The cooling means includes a Peltier element, the heat dissipation side surface of the Peltier element has a larger area than the heat absorption side surface, and the heat absorption side surface can be arranged facing the nerve bundle. The renal sympathetic nerve control device according to claim 2 or 3.   The cooling means has a Peltier element, the heat absorption side surface of the Peltier element can be arranged toward the nerve bundle, and the heat released from the heat dissipation side surface passes through an artery passing near the nerve bundle or The renal sympathetic nerve control device according to any one of claims 2 to 4, wherein the renal sympathetic nerve control device is configured to be able to conduct to a ureter or a peritoneum. The temperature control means has a heating means embedded in the user's body so that the nerve sympathetic nerve bundle can be heated.
The said drive means is comprised so that the said heating means may be driven so that autonomic nerve activity may be activated by heating the said nerve bundle, The Claim 1 thru | or 5 characterized by the above-mentioned. Renal sympathetic nerve control device.   The drive means includes a battery disposed in the user's body so that the temperature control means can be driven, and a switch that can control ON / OFF of the battery from outside the user's body, or A secondary coil arranged inside the user's body so that energy can be supplied to the temperature control means, and a primary coil arranged outside the user's body and capable of supplying energy nondestructively to the secondary coil The renal sympathetic nerve control device according to claim 2, comprising a transdermal energy transmission system including: A sensor for obtaining data relating to blood flow including blood pressure of the user and / or data relating to autonomic nerve activity of the user;
A controller provided to control renal sympathetic nerve activity so that the data acquired by the sensor approaches the value of a healthy person by controlling the driving means;
The renal sympathetic nerve control apparatus according to claim 2, wherein the renal sympathetic nerve control apparatus is provided.