JP2013233387A - Chemical indicator for plasma sterilization detection and ink composition - Google Patents
Chemical indicator for plasma sterilization detection and ink composition Download PDFInfo
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
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- KEZYHIPQRGTUDU-UHFFFAOYSA-N 2-[dithiocarboxy(methyl)amino]acetic acid Chemical compound SC(=S)N(C)CC(O)=O KEZYHIPQRGTUDU-UHFFFAOYSA-N 0.000 description 1
- MBXSHBIQMDKTEW-UHFFFAOYSA-N 3-bromobutanenitrile Chemical compound CC(Br)CC#N MBXSHBIQMDKTEW-UHFFFAOYSA-N 0.000 description 1
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- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
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- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
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Landscapes
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Inks, Pencil-Leads, Or Crayons (AREA)
Abstract
Description
本発明はプラズマ滅菌検知用ケミカルインジケータに関し、特に窒素ガスプラズマ滅菌における滅菌化学種を検知するプラズマ滅菌検知用ケミカルインジケータに関する。 The present invention relates to a chemical indicator for detecting plasma sterilization, and more particularly to a chemical indicator for detecting plasma sterilization for detecting sterilization chemical species in nitrogen gas plasma sterilization.
医療機関や研究施設などで使用される各種の器具や装置等に対しては、すべての微生物を死滅させるための滅菌処理が行われる。
従来の滅菌処理の方法としては、例えば、高圧蒸気滅菌、ホルムアルデヒドガス滅菌、過酸化水素ガス滅菌、過酢酸剤ガス滅菌、二酸化塩素ガス滅菌等が知られている。
Various instruments and devices used in medical institutions and research facilities are sterilized to kill all microorganisms.
As conventional sterilization methods, for example, high-pressure steam sterilization, formaldehyde gas sterilization, hydrogen peroxide gas sterilization, peracetic acid gas sterilization, chlorine dioxide gas sterilization, and the like are known.
また、過酸化水素プラズマ滅菌処理として、過酸化水素等の酸化性ガス雰囲気下でプラズマを発生させ、過酸化水素による殺菌を行う方法も知られている。 As a hydrogen peroxide plasma sterilization treatment, a method of generating plasma in an oxidizing gas atmosphere such as hydrogen peroxide and sterilizing with hydrogen peroxide is also known.
滅菌処理においては、滅菌後の残留物が無いことや、素材の劣化や浸食が生じないこと等が求められる。そのような要求を満たす滅菌方法として、近年、窒素ガス雰囲気下、または窒素ガス及び酸素ガスの混合ガス雰囲気下で、電磁パルスによりプラズマ照射を行い、励起されたラジカル種のみで滅菌を行う滅菌器が提案されている。この滅菌器のラジカル生成源は、窒素ガス、または窒素ガスと酸素ガスとの混合ガスであるため、人体に対する害が無く、安全性の面でも有利である。 In the sterilization process, it is required that there is no residue after sterilization and that no deterioration or erosion of the material occurs. As a sterilization method that satisfies such requirements, in recent years, a sterilizer that performs plasma irradiation with electromagnetic pulses in a nitrogen gas atmosphere or a mixed gas atmosphere of nitrogen gas and oxygen gas and sterilizes only with excited radical species. Has been proposed. Since the radical generation source of this sterilizer is nitrogen gas or a mixed gas of nitrogen gas and oxygen gas, there is no harm to the human body and it is advantageous from the viewpoint of safety.
従来の一般的な滅菌処理と同様に、プラズマ滅菌器による滅菌処理においても、滅菌処理の前後の被処理物の外観から滅菌処理の完了が確認できないため、滅菌工程を経たことを確認可能なケミカルインジケータ等の確認手段が必要である。
従来の過酸化水素プラズマ滅菌に用いられる過酸化水素プラズマ滅菌検知用インジケータ（例えば、特許文献１、２参照）としては、過酸化水素プラズマ滅菌において発生するラジカルにより変色すると称されるケミカルインジケータが提案されている。
As with conventional general sterilization treatments, even in the sterilization treatment using a plasma sterilizer, the completion of the sterilization treatment cannot be confirmed from the appearance of the workpiece before and after the sterilization treatment. A confirmation means such as an indicator is required.
As a hydrogen peroxide plasma sterilization detection indicator (for example, refer to Patent Documents 1 and 2) used in conventional hydrogen peroxide plasma sterilization, a chemical indicator that is said to be discolored by radicals generated in hydrogen peroxide plasma sterilization is proposed. Has been.
一方、上記の窒素ガス、または窒素ガスと酸素ガスとの混合ガス雰囲気下のプラズマ滅菌（以下、「窒素ガスプラズマ滅菌」という）において発生する主たる滅菌化学種は、一酸化窒素（ＮＯ）ラジカル、過酸化亜硝酸（ペルオキシナイトライト，ＯＯＮＯ）ラジカルならびに準安定状態の窒素酸化物等の活性窒素種（メタステーブル窒素）およびＯＨラジカルである。 On the other hand, the main sterilization chemical species generated in the above-described plasma sterilization in a nitrogen gas or mixed gas atmosphere of nitrogen gas and oxygen gas (hereinafter referred to as “nitrogen gas plasma sterilization”) are nitrogen monoxide (NO) radicals, Peroxynitrite (peroxynitrite, OONO) radicals and active nitrogen species such as metastable nitrogen oxides (metastable nitrogen) and OH radicals.
一酸化窒素ラジカルを検出することにより変色する変色剤としては、生体内の一酸化窒素の定量に用いられる蛍光物質が知られている（例えば、非特許文献１〜３参照）。しかしながら、窒素ガスプラズマ滅菌化学種である活性窒素種を検出し、可視光で視認可能な変色を示す変色剤は知られていない。 As a color changing agent that changes color by detecting a nitric oxide radical, a fluorescent substance used for quantification of nitric oxide in a living body is known (for example, see Non-Patent Documents 1 to 3). However, there is no known color changing agent that detects active nitrogen species, which are nitrogen gas plasma sterilized chemical species, and shows a color change visible with visible light.
一方、ＥＳＲ（電子スピン共鳴法）等による化学種の特定のための分析に用いられるラジカル捕捉剤も知られているが、ＥＳＲによる分析を行うことなく活性窒素種を可視的にかつ容易に検出する手段はまだ提案されていない。
窒素ガスプラズマ滅菌において発生する主たる滅菌化学種である、一酸化窒素（ＮＯ）ラジカル、過酸化亜硝酸（ペルオキシナイトライト、ＯＯＮＯ）ラジカル、準安定状態の窒素酸化物等の活性窒素種を特異的に検出し、かつ結果の視認性に優れたプラズマ滅菌検知ケミカルインジケータが求められているが、未だそのようなインジケータは提供されていないのが現状である。
On the other hand, radical scavengers used for analysis for specifying chemical species by ESR (electron spin resonance) are also known, but active nitrogen species can be detected visually and easily without analysis by ESR. No means has yet been proposed.
Specific active nitrogen species such as nitric oxide (NO) radicals, peroxynitrite (peroxynitrite, OONO) radicals, and metastable nitrogen oxides, which are the main sterilization chemical species generated in nitrogen gas plasma sterilization However, there is a need for a chemical indicator for detecting plasma sterilization that is highly detectable and has good visibility of the results, but such an indicator has not yet been provided.
そこで、本発明は上記課題を鑑み、窒素ガスプラズマ滅菌器による滅菌処理時に発生する主たる滅菌化学種である活性窒素種を特異的に検出し、かつ容易に色の変化として検知可能なプラズマ滅菌検知ケミカルインジケータを提供することを目的とする。 Therefore, in view of the above-mentioned problems, the present invention specifically detects active nitrogen species, which are main sterilization chemical species generated during sterilization by a nitrogen gas plasma sterilizer, and can easily detect a change in color as a plasma sterilization detection. An object is to provide a chemical indicator.
本発明者等は、鋭意研究を重ねた結果、Ｎ−（ジチオカルボキシ）サルコシン，二ナトリウム塩，二水和物（ＤＴＣＳ Ｎａ）と、ブロモクレゾールグリーン又はその塩とを含むインク組成物を用いることにより、窒素ガスプラズマ滅菌における滅菌化学種である活性窒素種により特異的に変色するプラズマ滅菌検知用ケミカルインジケータが得られることを見いだした。 As a result of extensive research, the present inventors use an ink composition containing N- (dithiocarboxy) sarcosine, disodium salt, dihydrate (DTCS Na) and bromocresol green or a salt thereof. Thus, it has been found that a chemical indicator for detecting plasma sterilization that is specifically discolored by an active nitrogen species that is a sterilization chemical species in nitrogen gas plasma sterilization can be obtained.
本発明は、ガスプラズマ滅菌に用いられるプラズマ滅菌検知用ケミカルインジケータであって、疎水性担体上に、Ｎ−（ジチオカルボキシ）サルコシン，二ナトリウム塩，二水和物（ＤＴＣＳ Ｎａ）とブロモクレゾールグリーン又はその塩とを含むインク組成物と、接着剤とで作製されたインク層が形成され、当該インク層が活性窒素種により変色することを特徴とするプラズマ滅菌検知用ケミカルインジケータである。
ここで、プラズマ滅菌検知用ケミカルインジケータは、活性窒素種を発生する滅菌器に用いられる滅菌検知用ケミカルインジケータであれば何にでも用い得るが、特に窒素ガスプラズマ滅菌器に用いられる滅菌検知用ケミカルインジケータであることが好ましい。
The present invention is a chemical indicator for detection of plasma sterilization used for gas plasma sterilization, which comprises N- (dithiocarboxy) sarcosine, disodium salt, dihydrate (DTCS Na) and bromocresol green on a hydrophobic carrier. Alternatively, the chemical indicator for detecting plasma sterilization is characterized in that an ink layer made of an ink composition containing a salt thereof and an adhesive is formed, and the ink layer is discolored by active nitrogen species.
Here, the chemical indicator for plasma sterilization detection can be used for any sterilization detection chemical indicator used in a sterilizer that generates active nitrogen species, but in particular, a sterilization detection chemical indicator used in a nitrogen gas plasma sterilizer. An indicator is preferred.
本発明によれば、窒素ガスプラズマ滅菌器による滅菌処理時に、発生した活性窒素種を特異的に検出し、かつ容易に検知可能なプラズマ滅菌検知用ケミカルインジケータを提供することができる。
また本発明のプラズマ滅菌検知用ケミカルインジケータは、空気に曝露されても酸化や可逆反応が起こりにくいため、信頼性の高いプラズマ滅菌検知用ケミカルインジケータとして機能する。
According to the present invention, it is possible to provide a chemical indicator for detecting plasma sterilization that can specifically detect active nitrogen species generated during sterilization by a nitrogen gas plasma sterilizer and can be easily detected.
The chemical indicator for detecting plasma sterilization according to the present invention functions as a highly reliable chemical indicator for detecting plasma sterilization because oxidation and reversible reaction hardly occur even when exposed to air.
以下、本発明のプラズマ滅菌検知用ケミカルインジケータについて説明する。
本発明のプラズマ滅菌検知用ケミカルインジケータは、疎水性担体上に、Ｎ−（ジチオカルボキシ）サルコシン，二ナトリウム塩，二水和物（ＤＴＣＳ Ｎａ）とブロモクレゾールグリーン又はその塩とを含むインク組成物と、接着剤とで作製されたインク層が形成され、当該インク層がプラズマ滅菌器の活性化学種である活性窒素種によって変色する。
活性窒素種としては、例えば、一酸化窒素（ＮＯ）ラジカル、過酸化亜硝酸（ペルオキシナイトライト、ＯＯＮＯ）ラジカルならびに準安定状態の窒素あるいは準安定状態の窒素酸化物などが挙げられる。
変色の機構については必ずしも明確ではないが、活性窒素種のＮＯがＮＯ2に酸化され、同時にブロムクレゾールグリーンのカルボニル基が還元されてフェノール性の水酸基となり黄変したと考えられる。
The chemical indicator for detecting plasma sterilization according to the present invention will be described below.
The chemical indicator for detection of plasma sterilization of the present invention is an ink composition comprising N- (dithiocarboxy) sarcosine, disodium salt, dihydrate (DTCS Na) and bromocresol green or a salt thereof on a hydrophobic carrier. Then, an ink layer made of the adhesive is formed, and the ink layer is discolored by an active nitrogen species that is an active chemical species of the plasma sterilizer.
Examples of the active nitrogen species include nitrogen monoxide (NO) radicals, peroxynitrite (Peroxynitrite, OONO) radicals, metastable nitrogen, and metastable nitrogen oxides.
Although the mechanism of discoloration is not necessarily clear, it is considered that NO of the active nitrogen species is oxidized to NO 2 and at the same time the carbonyl group of bromcresol green is reduced to become a phenolic hydroxyl group and yellowed.
〔インク組成物〕
本発明のプラズマ滅菌検知用ケミカルインジケータのインク層を形成するインク組成物は、窒素ガスプラズマ滅菌において生成する活性窒素種を捕捉する基剤であるＮ−（ジチオカルボキシ）サルコシン，二ナトリウム塩，二水和物（ＤＴＣＳ Ｎａ）と、ブロモクレゾールグリーン又はその塩と、溶剤を含む。
[Ink composition]
The ink composition forming the ink layer of the chemical indicator for plasma sterilization detection according to the present invention comprises N- (dithiocarboxy) sarcosine, disodium salt, two bases that capture active nitrogen species generated in nitrogen gas plasma sterilization. A hydrate (DTCS Na), bromocresol green or a salt thereof, and a solvent are included.
ＤＴＣＳ Ｎａは、水溶性が高く、従来から生体組織中のＮＯ測定に用いられているものである。本発明においては、このＤＴＣＳ Ｎａと特定の色素とを組み合わせて用いることで、ＤＴＣＳ Ｎａがプラズマ照射により生成した活性窒素種と特異的に反応し、還元反応により青から緑色であるブロモクレゾールグリーンの色が黄色に変色する。この変色により活性窒素種の存在を検知することができ、滅菌工程が行われたことを視認することができる。 DTCS Na is highly water-soluble and has been conventionally used for measuring NO in living tissues. In the present invention, by using this DTCS Na in combination with a specific dye, DTCS Na specifically reacts with the active nitrogen species generated by plasma irradiation, and the reduction reaction of bromocresol green, which is blue to green, is achieved. The color changes to yellow. The presence of the active nitrogen species can be detected by this discoloration, and it can be visually confirmed that the sterilization process has been performed.
インク組成物中のＤＴＣＳ Ｎａの配合量は、０．０５〜５．０重量％が好ましく、０．１〜２．５重量％がより好ましい。少なすぎると、活性窒素種の捕捉が不十分であり、多すぎると、変色の視認性の改善に変化は無く、未反応物が残留する可能性があり、いずれも変色が不十分となる。 The amount of DTCS Na in the ink composition is preferably 0.05 to 5.0% by weight, more preferably 0.1 to 2.5% by weight. If the amount is too small, the capture of active nitrogen species is insufficient. If the amount is too large, there is no change in the improvement in the visibility of discoloration, and unreacted substances may remain, and in all cases, discoloration is insufficient.
ブロモクレゾールグリーンは、ナトリウム塩などの金属塩であっても良く、その配合量は、０．１〜１０重量％が好ましく、０．５〜５重量％がより好ましい。少なすぎると、変色の視認性が不良となり、多すぎると、変色の視認性の改善に変化は無く、未反応物が残留する可能性がある。 Bromocresol green may be a metal salt such as a sodium salt, and the blending amount is preferably 0.1 to 10% by weight, and more preferably 0.5 to 5% by weight. If the amount is too small, the discoloration visibility becomes poor. If the amount is too large, there is no change in the discoloration improvement and unreacted substances may remain.
インク組成物中のＤＴＣＳ Ｎａ（Ａ）とブロモクレゾールグリーン又はその塩（Ｂ）との配合割合は、重量比で、（Ａ：Ｂ）＝（１：０．２）〜（１：２０）が好ましく、（Ａ：Ｂ）＝（１：０．４）〜（１：１０）がより好ましい。ブロモクレゾールグリーン又はその塩（Ｂ）の割合が少なすぎると変色の視認性が不良となり、多すぎると、還元されないブロモクレゾールグリーン又はその塩が残留するため、いずれも変色が不十分となる。 The blending ratio of DTCS Na (A) to bromocresol green or a salt thereof (B) in the ink composition is (A: B) = (1: 0.2) to (1:20) in weight ratio. Preferably, (A: B) = (1: 0.4) to (1:10) is more preferable. If the ratio of bromocresol green or its salt (B) is too small, the visibility of discoloration becomes poor. If it is too large, bromocresol green or a salt thereof that is not reduced remains, so that discoloration becomes insufficient.
溶剤としては、インク組成物に配合される成分の溶解性を考慮して適宜選択することができ、例えばエタノール、メタノール、酢酸エチル、イソプロパノール、ｎ−プロパノール、トルエン、シクロヘキサン、酢酸−ｎ−プロピルなどが挙げられるが、発色剤の安定性や形成したインク層の乾燥効率の観点から、イソプロパノールが好ましい。 The solvent can be appropriately selected in consideration of the solubility of components blended in the ink composition, such as ethanol, methanol, ethyl acetate, isopropanol, n-propanol, toluene, cyclohexane, acetic acid-n-propyl, etc. However, isopropanol is preferable from the viewpoint of the stability of the color former and the drying efficiency of the formed ink layer.
本発明のインク組成物は、上記のラジカルを捕捉する捕捉剤、発色剤、及び適宜選択されたその他の成分を溶剤に溶解して調製することができる。配合されるその他の成分としては、例えば、増量剤、可塑剤、分散剤、安定剤、増粘剤等の公知のインク組成物に用いられる成分が挙げられる。これらの成分のうち、溶剤以外の成分を溶剤に、同時又は順次配合し、公知の印刷用インク組成物の調製に用いられている攪拌機等の器具を用い、公知の混練方法等により均質に混合することにより、インク組成物を調製することができる。 The ink composition of the present invention can be prepared by dissolving the scavenger for capturing radicals, the color former, and other components appropriately selected in a solvent. Examples of other components to be blended include components used in known ink compositions such as extenders, plasticizers, dispersants, stabilizers, and thickeners. Among these components, components other than the solvent are blended in the solvent simultaneously or sequentially, and homogeneously mixed by a known kneading method or the like using an apparatus such as a stirrer used for preparing a known printing ink composition. By doing so, an ink composition can be prepared.
本発明のインク層の形成に当たっては、上記インク組成物と接着剤（バインダー）とを混合したものを用いる。インク組成物とバインダーとの混合割合は、後述する疎水性担体の材質や求められる耐久性などに応じて適宜選択することができるが、１：０．１〜１：１０（重量比）が好ましく、特に１：０．２〜１：５で用いられる。 In forming the ink layer of the present invention, a mixture of the ink composition and an adhesive (binder) is used. The mixing ratio of the ink composition and the binder can be appropriately selected according to the material of the hydrophobic carrier described later and the required durability, but is preferably 1: 0.1 to 1:10 (weight ratio). In particular 1: 0.2 to 1: 5.
バインダーとしては、ブロモクレゾールグリーン又はその塩の発色に影響を与えない限り、公知の印刷用インクの調製に用いられる合成樹脂などを適宜選択することができるが、前記ラジカルを捕捉する基剤と前記発色剤の担持体として、前記疎水性担体表面に強固に付着ないし接着するものが好ましい。
例えば、インク組成物としての安定性の観点から、ポリアミド、ポリウレタン、ポリエチレン、ポリエチレンテレフタレート、ポリスチレン等が挙げられ、具体的にはＶＥＲＳＡＭＩＤ ＰＵＲ １０１０（コグニス社製）が好ましい。
As the binder, as long as it does not affect the color development of bromocresol green or a salt thereof, a synthetic resin used for preparing a known printing ink can be appropriately selected. As the color former carrier, one that adheres or adheres firmly to the surface of the hydrophobic carrier is preferable.
For example, from the viewpoint of stability as an ink composition, polyamide, polyurethane, polyethylene, polyethylene terephthalate, polystyrene and the like can be mentioned. Specifically, VERSAMID PUR 1010 (manufactured by Cognis) is preferable.
得られたインク組成物とバインダーの混合物を疎水性担体上に印刷することにより、インク層を形成する。インク組成物とバインダーは、混合後速やかに印刷することが好ましい。
印刷方法としては、公知の印刷方法、例えば、インクジェット法、シルクスクリーン印刷、グラビア印刷、オフセット印刷、凸版印刷、フレキソ印刷等の方法が挙げられる。
印刷後、形成されたインク層に対し、７５〜８０℃で乾熱乾燥を行うことにより、ラミネーションコーティングが行われる。
The ink layer is formed by printing the mixture of the obtained ink composition and binder on a hydrophobic carrier. It is preferable to print the ink composition and the binder immediately after mixing.
Examples of the printing method include known printing methods such as an inkjet method, silk screen printing, gravure printing, offset printing, letterpress printing, and flexographic printing.
After printing, lamination coating is performed on the formed ink layer by performing dry heat drying at 75 to 80 ° C.
インク層形成に用いられるインク組成物の量としては特に制限はなく、検知結果が視認できるように適宜選択することができるが、不揮発分（ＤＴＣＳ Ｎａとブロモクレゾールグリーン又はその塩の合計量）に換算して０．０１〜４ｇ／ｃｍ2が好ましく、０．０５〜２ｇ／ｃｍ2がより好ましい。 There is no restriction | limiting in particular as an amount of the ink composition used for ink layer formation, Although it can select suitably so that a detection result can be visually recognized, it is non-volatile (total amount of DTCS Na and bromocresol green, or its salt). In terms of conversion, 0.01 to 4 g / cm 2 is preferable, and 0.05 to 2 g / cm 2 is more preferable.
〔疎水性担体〕
前記インク層が形成される疎水性担体について説明する。
本発明のケミカルインジケータは内部に被滅菌物を収納する滅菌用包装材料(滅菌バッグ)の表面あるいは、該滅菌バッグ内にあって用いられる。
疎水性担体としては疎水性の高分子シートであれば特に限定されず、ポリエチレン、ポリプロピレン、ポリエチレンテレフタレート、ポリスチレン等が挙げられ、特にそれらの不織布が好ましい。
[Hydrophobic carrier]
A hydrophobic carrier on which the ink layer is formed will be described.
The chemical indicator of the present invention is used on the surface of a sterilization packaging material (sterilization bag) for storing an object to be sterilized therein or in the sterilization bag.
The hydrophobic carrier is not particularly limited as long as it is a hydrophobic polymer sheet, and examples thereof include polyethylene, polypropylene, polyethylene terephthalate, polystyrene, and the like, and those nonwoven fabrics are particularly preferable.
実使用においては、疎水性担体は、滅菌バッグ表面の一部をなし、ガス透過性の不織布により構成される滅菌可能な領域、すなわちプラズマ滅菌処理に際して、有効成分である窒素ガスまたは窒素ガス及び酸素ガスの混合ガスを透過させ、かつ菌は透過させない透過性を有する不織布からなる領域が好ましい。収納滅菌用包装材料の全体をそのようなガス透過性の不織布で構成することもできるが、コスト、強度、内容物の視認性等の観点から、例えば、袋状に成形された収納滅菌用包装材料の一方の面を該不織布で構成し、他方の面を透明な合成樹脂製シートなどで構成することもできる。
かかる不織布としては、例えば、高密度ポリエチレンからなるフラッシュ紡糸不織布であるＴｙｖｅｋ１０７３Ｂ（タイベック：登録商標、旭・デュポン株式会社製）などが挙げられる。
また、疎水性担体はスティック状あるいはシート状であってもよい。この場合は滅菌バッグの内部に収納して用いられる。
In actual use, the hydrophobic carrier forms part of the surface of the sterilization bag and is a sterilizable region constituted by a gas-permeable nonwoven fabric, that is, nitrogen gas or nitrogen gas and oxygen, which are active ingredients during plasma sterilization treatment. The area | region which consists of a nonwoven fabric which permeate | transmits the mixed gas of gas and does not permeate | transmit bacteria is preferable. Although the entire packaging material for storage sterilization can be composed of such a gas-permeable nonwoven fabric, from the viewpoint of cost, strength, visibility of contents, etc., for example, packaging for storage sterilization formed into a bag shape One surface of the material can be composed of the nonwoven fabric, and the other surface can be composed of a transparent synthetic resin sheet or the like.
Examples of such a nonwoven fabric include Tyvek 1073B (Tyvek: registered trademark, manufactured by Asahi DuPont Co., Ltd.), which is a flash spun nonwoven fabric made of high-density polyethylene.
Further, the hydrophobic carrier may be in the form of a stick or a sheet. In this case, it is used by being housed in a sterilization bag.
〔プラズマ滅菌検知用ケミカルインジケータ〕
本発明のプラズマ滅菌検知用ケミカルインジケータは、前記疎水性担体上に、前記ラジカルを捕捉する基剤としてＤＴＣＳ Ｎａ、前記発色剤としてブロモクレゾールグリーン又はその塩とを含む前記インク組成物と、接着剤とで作製されたインク層が形成され、当該インク層が活性窒素種により変色することにより、窒素ガスプラズマ滅菌処理が行われたことを検知することができる。
疎水性担体が、滅菌用包装材料(滅菌バッグ)表面の一部(例えばポリエチレン不織布)である場合は、被滅菌物をプラズマ滅菌装置の雰囲気内に入れた際に主たる化学種が滅菌バッグに接触したことをケミカルインジケータとして視認できる。
また疎水性担体が滅菌バッグ内に収納可能な程度に小さいスティック状あるいはシート状の場合は、被滅菌物を入れた滅菌バッグの中にきちんと主たる化学種が接触したこと、すなわち滅菌バッグ内部に浸透したことをケミカルインジケータの変色結果から確認でき、このことは被滅菌物が確実に滅菌工程を通過したことを意味する。
[Chemical indicator for plasma sterilization detection]
The chemical indicator for detecting plasma sterilization according to the present invention includes the ink composition containing DTCS Na as a base for capturing the radicals and bromocresol green or a salt thereof as the color former on the hydrophobic carrier, and an adhesive. The ink layer produced in the above is formed, and the ink layer is discolored by the active nitrogen species, so that it can be detected that the nitrogen gas plasma sterilization treatment has been performed.
When the hydrophobic carrier is a part of the surface of the packaging material (sterilization bag) for sterilization (for example, non-woven polyethylene), the main chemical species come into contact with the sterilization bag when the article to be sterilized is placed in the atmosphere of the plasma sterilizer. This can be visually recognized as a chemical indicator.
If the hydrophobic carrier is in the form of a stick or sheet that is small enough to be accommodated in the sterilization bag, the main chemical species have come into contact with the sterilization bag containing the material to be sterilized. This can be confirmed from the discoloration result of the chemical indicator, which means that the article to be sterilized has surely passed the sterilization process.
本発明のプラズマ滅菌検知用ケミカルインジケータを適用可能な窒素ガスプラズマ滅菌装置としては、例えば、日本ガイシ社製の窒素ガスプラズマ滅菌器が挙げられる。この窒素ガスプラズマ滅菌器において発生する主たる滅菌化学種は、一酸化窒素（ＮＯ）ラジカル、過酸化亜硝酸（ペルオキシナイトライト，ＯＯＮＯ）ラジカルならびに準安定状態の窒素酸化物等の活性窒素種（メタステーブル窒素）およびＯＨラジカルであることがわかった（Shintani,H.,Biocontrol Science,Vol.12,No.4,131-143(2007)。特にTABLE 2.およびTABLE 3.参照）。 Examples of the nitrogen gas plasma sterilization apparatus to which the chemical indicator for detecting plasma sterilization according to the present invention can be applied include a nitrogen gas plasma sterilizer manufactured by NGK. The main sterilizing chemical species generated in this nitrogen gas plasma sterilizer are active nitrogen species such as nitric oxide (NO) radicals, peroxynitrite (Peroxynitrite, OONO) radicals, and metastable nitrogen oxides (metas). Table Nitrogen) and OH radicals (Shintani, H., Biocontrol Science, Vol. 12, No. 4, 131-143 (2007), especially see TABLE 2. and TABLE 3.).
本発明のプラズマ滅菌検知用ケミカルインジケータは、プラズマ照射による滅菌化学種の発生を検知することにより、滅菌物が滅菌工程を通過したか否かを区別するために使用されるプロセスインジケータである。すなわち、ＩＳＯ １１１４０−１による化学的インジケータのクラス分類のクラス１に分類されるものである。 The chemical indicator for detecting plasma sterilization according to the present invention is a process indicator used for distinguishing whether or not a sterilized product has passed through a sterilization step by detecting generation of sterilization chemical species by plasma irradiation. That is, it is classified into class 1 of the chemical indicator class classification according to ISO 11140-1.
以下、本発明のプラズマ滅菌検知用ケミカルインジケータを具体的な実施例を用いて詳細に説明するが、本発明はこれらに制限されるものではない。 Hereinafter, although the chemical indicator for plasma sterilization detection of this invention is demonstrated in detail using a specific Example, this invention is not restrict | limited to these.
実施例１（滅菌バッグ表面のケミカルインジケータ）
（１）インク組成物の調製
以下に示す成分（Ａ）を攪拌機を用いて十分に混合してインク組成物を調製した後、（Ａ）と（Ｂ）を１：１（重量比）の割合で混合して印刷用インクを得た。
（Ａ）インク成分
・ＤＴＣＳ Ｎａ ０．４質量部
・ブロモクレゾールグリーンナトリウム塩 ０．８質量部
・イソプロパノール ７８質量部
（Ｂ）接着剤（バインダー）
・ＶＥＲＳＡＭＩＤ（登録商標） ＰＵＲ １０１０（コグニス社製）
Example 1 (chemical indicator on the surface of a sterilization bag)
(1) Preparation of ink composition After preparing the ink composition by fully mixing the following component (A) using a stirrer, the ratio of (A) and (B) is 1: 1 (weight ratio). To obtain a printing ink.
(A) Ink component DTCS Na 0.4 part by mass Bromocresol green sodium salt 0.8 part by mass Isopropanol 78 part by mass (B) Adhesive (binder)
・ VERSAMID (registered trademark) PUR 1010 (manufactured by Cognis)
（２）インク層の形成
滅菌バッグとして、ポリエチレンテレフタレート（ＰＥＴ）とポリエチレン（ＰＥ）からなる積層フィルム（三栄産業株式会社製）と高密度ポリエチレン不織布（タイベック（登録商標）１０７３Ｂ、旭・デュポン株式会社製）とを熱圧着して貼合した専用滅菌バッグを用いた。
上記（１）で調製した印刷用インクを使用し、滅菌バッグの高密度ポリエチレン不織布からなる面にグラビア印刷法にて印刷を行い、インク層を形成した。
グラビア印刷は手動グラビア印刷機を用いて、レーザー製版１６０〜１８０線／インチ、版深２０〜３０μｍに設定してグラビア印刷を行った。印刷されたインク量（乾燥後）は０．４ｇ／ｃｍ2であった。
形成したインク層に対し、７９℃で乾熱乾燥を行った後、８０℃で１分間再加熱してラミネーションフィルムコーティングした。
(2) Formation of ink layer As a sterilization bag, a laminated film made of polyethylene terephthalate (PET) and polyethylene (PE) (manufactured by Sanei Sangyo Co., Ltd.) and a high density polyethylene nonwoven fabric (Tyvek (registered trademark) 1073B, Asahi DuPont Co., Ltd. And a special sterilization bag bonded by thermocompression bonding.
Using the printing ink prepared in (1) above, printing was performed on the surface of the sterilized bag made of high-density polyethylene nonwoven fabric by the gravure printing method to form an ink layer.
Gravure printing was carried out using a manual gravure printing machine with laser plate making of 160 to 180 lines / inch and plate depth of 20 to 30 μm. The amount of ink printed (after drying) was 0.4 g / cm 2 .
The formed ink layer was dry-heat dried at 79 ° C., and then reheated at 80 ° C. for 1 minute for lamination film coating.
（３）プラズマ滅菌検知用ケミカルインジケータの評価
上記（２）でインク層を形成して得られたプラズマ滅菌検知用ケミカルインジケータを、窒素ガスプラズマ滅菌器（日本ガイシ株式会社製）に投入し、窒素ガスを以下の条件でプラズマ化させる。
（滅菌稼働条件）
電源：４０mJ/パルス,
電圧：１４．５kV,
電流：３２A,
周波数：１kHz,
温度：４８−６０℃,
窒素流速：１．５L/分、
気圧：1／3気圧
以上の滅菌器稼働条件で窒素ガスをプラズマ化し、発生するラジカルによって滅菌処理を行い、プラズマ曝露２０分経過後のインク層の色の変化を目視により観察した。
その結果、滅菌処理前には青から緑色であったインク層の色が、黄色に変化していることが確認された。
以上のことから、病院の作業員などで、フリーラジカルに関して十分な知識がなくても、色の変化で容易に滅菌できたか否かを判別することが可能となった。
(3) Evaluation of chemical indicator for detection of plasma sterilization The chemical indicator for detection of plasma sterilization obtained by forming the ink layer in (2) above was introduced into a nitrogen gas plasma sterilizer (manufactured by NGK Corporation), and nitrogen was added. The gas is turned into plasma under the following conditions.
(Sterilization operating conditions)
Power supply: 40mJ / pulse,
Voltage: 14.5kV,
Current: 32A,
Frequency: 1kHz,
Temperature: 48-60 ° C,
Nitrogen flow rate: 1.5 L / min,
Atmospheric pressure: Nitrogen gas was converted to plasma under sterilizer operating conditions of 1/3 atmospheric pressure or higher, and sterilization was performed with the generated radicals. The change in color of the ink layer after 20 minutes of plasma exposure was visually observed.
As a result, it was confirmed that the color of the ink layer, which was blue to green before sterilization, was changed to yellow.
From the above, it has become possible for hospital workers and the like to determine whether or not sterilization can be easily performed by a color change without sufficient knowledge about free radicals.
本発明のプラズマ滅菌検知用ケミカルインジケータによれば、窒素ガスプラズマ滅菌器による滅菌処理時に、発生する活性窒素種を特異的に検出し、かつ容易に検知可能であり、被滅菌物に対しプラズマ滅菌処理が行われたか否かを目視で容易かつ明確に判定することができ、クラス1レベルのケミカルインジケータ（化学指標、ＩＳＯ １１１４０、化学指標に関する国際規格）の作成が達成されたということになる。ここでクラス1と言うのは、滅菌プロセス上である一定のバリデートされた値に到達した瞬間から変色が起こるケミカルインジケータのことである。 According to the chemical indicator for plasma sterilization detection of the present invention, the active nitrogen species generated can be specifically detected and easily detected during sterilization by a nitrogen gas plasma sterilizer, and plasma sterilization can be performed on an object to be sterilized. Whether or not processing has been performed can be easily and clearly determined visually, and the creation of class 1 level chemical indicators (chemical indicators, ISO 11140, international standards for chemical indicators) has been achieved. Class 1 here refers to a chemical indicator that changes color from the moment when a certain validated value is reached on the sterilization process.
実施例２（スティックタイプのケミカルインジケータ）
厚さ５０μｍのポリエチレンテレフタレート（ＰＥＴ）を５０ｍｍ×１０ｍｍの短冊状に裁断する。
一方、実施例１におけると同様に、高密度ポリエチレン不織布シートにインク層を形成してケミカルインジケータ材とし、このケミカルインジケータ材を１０ｍｍ×１０ｍｍの短冊状に裁断する。
上記のポリエチレンテレフタレート（ＰＥＴ）とケミカルインジケータ材のそれぞれの端部を接着剤（フジアット１１−３（株式会社Ｔ＆Ｋ ＴＯＫＡ製））で接着した後、乾燥してスティックタイプのケミカルインジケータを得た。
得られたケミカルインジケータを滅菌バッグ内に入れ、実施例１におけると同様に評価したところ、実施例１と同様の結果が得られた。
Example 2 (stick type chemical indicator)
Polyethylene terephthalate (PET) having a thickness of 50 μm is cut into a 50 mm × 10 mm strip.
On the other hand, as in Example 1, an ink layer is formed on a high-density polyethylene nonwoven fabric sheet to obtain a chemical indicator material, and this chemical indicator material is cut into a strip of 10 mm × 10 mm.
After sticking each edge part of said polyethylene terephthalate (PET) and a chemical indicator material with the adhesive agent (FUJIAT 11-3 (made by T & K TOKA Corporation)), it dried and the stick-type chemical indicator was obtained.
When the obtained chemical indicator was put in a sterilization bag and evaluated in the same manner as in Example 1, the same result as in Example 1 was obtained.
Claims (5)
疎水性担体上に、Ｎ−（ジチオカルボキシ）サルコシン，二ナトリウム塩，二水和物とブロモクレゾールグリーン又はその塩とを含むインク組成物と、接着剤とで作製されたインク層が形成され、該インク層が活性窒素種により変色することを特徴とするプラズマ滅菌検知用ケミカルインジケータ。 A chemical indicator for detecting plasma sterilization used for gas plasma sterilization,
An ink layer made of an ink composition containing N- (dithiocarboxy) sarcosine, disodium salt, dihydrate and bromocresol green or a salt thereof and an adhesive is formed on a hydrophobic carrier, A chemical indicator for detecting plasma sterilization, wherein the ink layer is discolored by active nitrogen species.
Ｎ−（ジチオカルボキシ）サルコシン，二ナトリウム塩，二水和物と、ブロモクレゾールグリーン又はその塩と、溶剤を含むことを特徴とするインク組成物。 An ink composition for use in a chemical indicator for detecting plasma sterilization that changes color depending on the active nitrogen species according to claim 1,
An ink composition comprising N- (dithiocarboxy) sarcosine, disodium salt, dihydrate, bromocresol green or a salt thereof, and a solvent.
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015163203A1 (en) * | 2014-04-21 | 2015-10-29 | 株式会社サクラクレパス | Ink composition for detecting plasma treatment and indicator for detecting plasma treatment |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004513667A (en) * | 1999-08-05 | 2004-05-13 | スリーエム イノベイティブ プロパティズ カンパニー | Chemical indicator reader |
| JP2004203464A (en) * | 2002-12-26 | 2004-07-22 | Daiwa Can Co Ltd | Defective can detection method and thermo-ink printing can used for it |
| JP2005315828A (en) * | 2004-03-30 | 2005-11-10 | Sakura Color Prod Corp | Hydrogen peroxide plasma sterilization sensing ink composition and hydrogen peroxide plasma sterilization sensing indicator |
| JP2012101109A (en) * | 2012-01-10 | 2012-05-31 | Fujimori Kogyo Co Ltd | Indicator for plasma sterilization, and packaging material for sterilization |
-
2012
- 2012-05-11 JP JP2012109327A patent/JP5465749B2/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004513667A (en) * | 1999-08-05 | 2004-05-13 | スリーエム イノベイティブ プロパティズ カンパニー | Chemical indicator reader |
| JP2004203464A (en) * | 2002-12-26 | 2004-07-22 | Daiwa Can Co Ltd | Defective can detection method and thermo-ink printing can used for it |
| JP2005315828A (en) * | 2004-03-30 | 2005-11-10 | Sakura Color Prod Corp | Hydrogen peroxide plasma sterilization sensing ink composition and hydrogen peroxide plasma sterilization sensing indicator |
| JP2012101109A (en) * | 2012-01-10 | 2012-05-31 | Fujimori Kogyo Co Ltd | Indicator for plasma sterilization, and packaging material for sterilization |
Cited By (16)
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|---|---|---|---|---|
| US20160133444A1 (en) * | 2013-06-04 | 2016-05-12 | Sakura Color Products Corporation | Ink composition for detecting plasma treatment and indicator for detecting plasma treatment |
| US20160141192A1 (en) | 2013-08-22 | 2016-05-19 | Sakura Color Products Corporation | Indicator used in electronic device manufacturing apparatus and method for designing and/or managing the apparatus |
| US10181414B2 (en) | 2013-08-22 | 2019-01-15 | Sakura Color Products Corporation | Indicator used in electronic device manufacturing apparatus and method for designing and/or managing the apparatus |
| US10401338B2 (en) | 2014-02-14 | 2019-09-03 | Sakura Color Products Corporation | Plasma processing detection indicator |
| WO2015163203A1 (en) * | 2014-04-21 | 2015-10-29 | 株式会社サクラクレパス | Ink composition for detecting plasma treatment and indicator for detecting plasma treatment |
| US10184058B2 (en) | 2014-04-21 | 2019-01-22 | Sakura Color Products Corporation | Ink composition for detecting plasma treatment and indicator for detecting plasma treatment |
| US10180392B2 (en) | 2014-05-09 | 2019-01-15 | Sakura Color Products Corporation | Plasma processing detection indicator using inorganic substance as a color-change layer |
| US10400125B2 (en) * | 2014-09-16 | 2019-09-03 | Sakura Color Products Corporation | Ink composition for plasma treatment detection, and plasma treatment detection indicator |
| US20170101548A1 (en) * | 2014-09-16 | 2017-04-13 | Sakura Color Products Corporation | Ink composition for plasma treatment detection, and plasma treatment detection indicator |
| US10180413B2 (en) | 2014-12-02 | 2019-01-15 | Sakura Color Products Corporation | Ink composition for plasma processing detection, and indicator for plasma processing detection using said ink composition |
| WO2018150970A1 (en) * | 2017-02-15 | 2018-08-23 | オリンパス株式会社 | Coating for medical equipment and medical equipment |
| JP2024508619A (en) * | 2021-01-26 | 2024-02-28 | ステラル ステート エルエルシー | Apparatus and method for detecting the presence of nitric oxide |
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