JP2013006790A - O/w-type emulsion - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an O/W-type emulsion which retains moisture by forming a water retention membrane on a skin, has a function for preventing the evaporation of the moisture, and keeps a ceratoid water content, by which a fresh and youthful skin can be obtained, and a softening effect can be expected, which has a wet and smooth feeling when applied on the skin, by which a fresh use feeling can be obtained, and which is most suitable for hand cream.SOLUTION: The O/W-type emulsion is obtained by emulsifying an oil phase containing meadowfoam oil, a higher alcohol, vaseline, and oil-soluble N-long-chain acyl acidic amino acid ester, and a water phase containing trimethylglycine, a water-soluble high polymer and a polyalcohol with an emulsifying agent containing phospholipid.

Description

  The present invention has a function of retaining moisture by forming a water retaining film on the skin, and further preventing moisture from evaporating, maintaining the amount of moisture in the keratin, obtaining a fresh skin, and also expecting a softening effect. The present invention relates to an O / W type emulsion that is optimal for hand creams, which provides a refreshing feeling of use with a moist and smooth feel on skin.

The basic requirement for emulsions applied to the skin is to maintain a moisture content of the keratin, obtain a fresh skin, have a moist and smooth feel on the skin, and have a refreshing feeling of use. It has been.
In order to increase the moisturizing property, polyhydric alcohols such as glycerin are used. However, when the polyhydric alcohol is mainly used for improving the moisturizing property, only a solid preparation with a feeling of use can be obtained. Of course, various oil phase components are selected to properly occlude the skin and keep the water content.
However, it is difficult to obtain a cream with a refreshing feeling of use while maintaining a sufficient amount of keratin moisture and being moist and moist.

JP 2011-093835 A JP 2011-111402 A

  An object of the present invention is to obtain an emulsion for an external preparation for skin, which retains the amount of moisture in the keratin, obtains fresh skin, has a moist and smooth feel on the skin, and has a refreshed feeling of use.

  As a result of intensive studies by the present inventors, an oil phase containing meadow foam oil, higher alcohol, petrolatum, oil-soluble N-long chain acyl acidic amino acid ester, and an aqueous phase containing trimethylglycine, a water-soluble polymer, and a polyhydric alcohol It was found that an O / W type emulsion emulsified with an emulsifier containing phospholipid achieves the object of the present invention.

Meadowfoam oil is an oil extracted from the seeds of the Limnanthaceae plant, Limnanthes alba. It is an oil mainly composed of triglycerides composed of about 60% eicosenoic acid, about 15% erucic acid and long chain fatty acids. is there.
Examples of the higher alcohol include lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, oleyl alcohol, and behenyl alcohol. These components may be used alone or in combination of two or more. It is preferable to use cetyl alcohol, stearyl alcohol or behenyl alcohol.
Vaseline is obtained by decolorizing and purifying a mixture of hydrocarbons obtained from petroleum. In the present invention, it is preferable to use one having a freezing point of 38 to 60 ° C. and a consistency of 140 to 200.

The oil-soluble N-long chain acyl acidic amino acid ester will be described. First, the long chain acyl group is an acyl group derived from a saturated or unsaturated fatty acid having 8 to 22 carbon atoms, such as lauric acid, palmitic acid, stearic acid, olein. In addition to acyl groups of fatty acids of a single composition such as acids, mixed fatty acids obtained from nature such as coconut oil fatty acid, beef tallow fatty acid, hardened tallow fatty acid, or synthetic fatty acids (including branched fatty acids) There may be.
The acidic amino acid is selected from aspartic acid and glutamic acid.
Examples of alcohols that are ester-linked to this include saturated, unsaturated, branched aliphatic alcohols having 8 to 30 carbon atoms, cholesterols such as cholesterol, lanosterol, stigmasterol, hydrogenated products thereof, and combinations thereof. These mono- or diesters or mixtures thereof, alone or as a mixture, are used.
In practice, N-lauroyl-L-glutamate di (cholesteryl octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl 2-octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl behenyl 2- Octyldodecyl) and N-lauroyl-L-glutamate di (cholesteryl behenyl octyldodecyl) are also commercially available for use in the present invention and have high utility in physical properties.

In addition, oils and fats, oil-soluble active ingredients and the like as exemplified below are blended as necessary.
Avocado oil, almond oil, olive oil, sesame oil, beef tallow fatty acid, safflower oil, shea butter, soybean oil, camellia oil, cottonseed oil, peanut oil, turtle oil, mink oil, palm oil, palm kernel oil, owl, coconut oil, beef tallow , Pork fat, squalene, squalane, pristane, beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax, rice wax, various hydrogenated fats and waxes, etc. .
Mineral oils such as paraffin, ceresin, microcrystalline wax, olefin oligomer, light isoparaffin, light liquid isoparaffin, liquid paraffin, liquid isoparaffin, pristane, hydrogenated polybutene, hydrogenated polydecene, heavy liquid isoparaffin.
Fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, and 12-hydroxystearic acid.
Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, myristyl lactate, lanolin acetate, monostearate Esters such as ethylene glycol acid, propylene glycol monostearate, propylene glycol dioleate;
. Furthermore, oil-soluble vitamins such as vitamin A oil, vitamin A palmitate, vitamin A acetate, riboflavin, vitamin C dipalmitate, ergocalciferol, vitamin E, vitamin E acetate, vitamin E nicotinate.
Ethyl hexyl paramethoxycinnamate, isopropyl paramethoxycinnamate, octyl paramethoxycinnamate, octyl dimethoxybenzylidenedioxoimidazolidinepropionate, hexyl diethylaminohydroxybenzoylbenzoate, t-butylmethoxydibenzoylmethane, ethylhexyltriazone, UV absorbers such as octoclerin, oxybenzone, hydroxybenzophenone sulfonic acid, sodium dihydroxybenzophenone sulfonate, dihydroxybenzophenone, paraaminobenzoic acid.
Oil-soluble components of plants such as eucalyptus oil, wild rose oil, armor oil, roman chamomile oil, fennel oil, mint oil, bergamot oil, peppermint oil, spearmint oil, basil oil, thyme oil, laurel leaf oil, oil-soluble licorice and the like.
Beta carotene, astaxanthin, cholesterol, phytosterol, ceramide, guaiazulene, benzyl nicotinate, dibutylhydroxytoluene and butylhydroxyanisole.

The blending amount and blending balance of Meadowfoam oil, higher alcohol, petrolatum, and oil-soluble N-long chain acyl acidic amino acid ester vary depending on the types of these raw materials, the types and amounts of other raw materials, and the intended use of the preparation. However, the following ranges are basically preferable.
First, although it is the ratio of the whole oil phase, it mix | blends so that the ratio with respect to the whole composition may be 10-30%.
Next, in the proportion of oil phase, Medofoam oil is 30-70%, higher alcohol is 15-30%, petrolatum is 6-15%, oil-soluble N-long chain acyl acidic amino acid ester is 3-10% It was also found by the inventors' study that blending in such a manner is consistent with the gist of the present invention.

Next, the aqueous phase is trimethylglycine. Trimethylglycine is contained in foods such as vegetables and mushrooms, and especially in sugar beet (sugar beet), the nitrogen of glycine is methylated to the form of quaternary ammonium. It is an organic compound with a structured structure.
The blending amount of trimethylglycine is preferably 0.5 to 20.0%.
Next, as polyhydric alcohol, glycerin, diglycerin, 1,2 pentanediol, 1,3 butylene glycol, propylene glycol, dipropylene glycol, 1,2-hexanediol, isopentyldiol, ethylhexanediol, ozonization Glycerin, caprylyl glycol, glycol, diethylene glycol, dithiaoctanediol, thioglycerin, 1,10-decanediol, decylene glycol, triethylene glycol, chilimethyl gydoxymethylcyclohexanol, phytanetriol, phenoxypropanediol, 1,2-butanediol, 2,3-butanediol, butylethylpropanediol, hexylene glycol, methylpropanediol, menthanediol, lauryl glycol Inositol, erythritol, xylitol, sorbitol, maltitol, mannitol, lactitol and the like are go up.
The blending amount of the polyhydric alcohol varies greatly depending on the type thereof, but is preferably 1.0 to 30.0%.

Examples of water-soluble polymers include sodium polyacrylate, cellulose ether, calcium alginate, carboxyvinyl polymer, ethylene / acrylic acid copolymer, vinyl pyrrolidone polymer, vinyl alcohol / vinyl pyrrolidone copolymer, nitrogen-substituted acrylamide polymer, Cationic polymers such as polyacrylamide, cationized gar gum, dimethylacrylammonium polymer, acrylic acid / methacrylic acid acrylic copolymer, POE / POP copolymer, polyvinyl alcohol, hyaluronic acid, collagen, pullulan, agar, gelatin, tamarind seed Polysaccharides, xanthan gum, carrageenan, high methoxyl pectin, low methoxyl pectin, gar gum, gum arabic, crystalline cellulose, arabinogalactan, karaya gum, Ragakantogamu, alginic acid, albumin, casein, curdlan, gellan gum, dextran, cellulose, polyethylene imine, polyethylene glycol, highly polymerized polyethylene glycol, cationized silicone polymer and the like.
The blending amount of the water-soluble polymer varies greatly depending on the type thereof, but is preferably 0.1 to 10.0%.

In addition to this, a water-soluble component, a water-soluble active ingredient, and the like are blended as necessary.
These oil phase and aqueous phase are emulsified with an emulsifier, and phospholipids are used.
Examples of the phospholipid include phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, phosphatidic acid, lysophosphatidylcholine, lysophosphatidylethanolamine, and a composition containing these, i.e., soybean. Examples include lecithin, egg yolk lecithin, corn lecithin and hydrogenated products thereof.
The amount of phospholipid blended varies depending on the type of phospholipid, the purpose of the preparation, and other raw materials, particularly the type and blending amount of the oil phase, but is preferably 0.01 to 10%.
Of course, there is no problem to mix other emulsifiers.

  Further, when the copolymer of the formula (1) is blended, the effect is increased. Among these, m is preferably 20 to 200, n is 30 to 500, and R has 12 to 20 carbon atoms.

The production method is not particularly limited and may be performed by a commonly used method, and is exemplified below.
If necessary, dissolve by warming, mix the oil phase, water phase and emulsifier with stirring, and if warmed, cool to room temperature.
The mixing is performed using an emulsifier such as a homomixer, a colloid mill, a homogenizer, or a propeller mixer depending on the type and amount of the emulsifier and the purpose of use of the preparation.

Examples are described below. In addition, the number of an Example is a weight part.
In addition, the manufacturing method heated the oil phase and what added the emulsifier to the water phase to 80 degreeC, respectively, and added the oil phase gradually to what added the emulsifier to the water phase, stirring with a homomixer. . This was cooled to 35 ° C. with slow stirring.

Example 1
Meadow Foam Oil 10.0
Vaseline 2.5
Stearyl alcohol 2.0
Cetyl alcohol 2.0
N-lauroyl-L-glutamate di (cholesteryl 1.5
Le behenyl octyldodecyl)

Hydrogenated phospholipid 1.0

Water 69.3
Trimethylglycine 2.0
Hyaluronic acid 0.5
Glycerin 2.0
1,3 Butylene glycol 5.0
1,2 pentanediol 2.0
Methyl paraoxybenzoate 0.2

Example 2
Meadow Foam Oil 8.5
Vaseline 2.0
Stearyl alcohol 2.0
Behenyl alcohol 2.5
N-lauroyl-L-glutamic acid di (phytoste 1.0
Lil 2-octyldodecyl)
Squalane 7.5
Paraffin wax 135 ° F 3.5

Monomyristic acid polyglycerol (0.5% of glycerol)
Average polymerization degree is 8)
Hydrogenated phospholipid 0.5

Water 56.1
Trimethylglycine 10.0
Xanthan gum 0.5
Carboxyvinyl polymer (1% aqueous solution pH 7.0 neutralized) 1.0
Polyacrylic acid amide 0.2
Hyaluronic acid 1.0
Dipropylene glycol 1.0
1,3-butylene glycol 1.0
1,2 pentanediol 1.0
Methyl paraoxybenzoate 0.2

Example 3
Meadow foam oil 7.8
Vaseline 1.0
Stearyl alcohol 1.0
Behenyl alcohol 1.0
N-lauroyl-L-glutamate di (cholesteryl 0.5
Le behenyl octyldodecyl)
N-lauroyl-L-glutamic acid di (phytoste 0.7
Lil 2-octyldodecyl)
Vitamin E 0.5
Vitamin A oil 0.5

Polyoxyethylene (7EO) lauryl ether 0.2
Hydrogenated phospholipid 0.2
Hydrogenated lysophospholipid 0.2

Water 71.4
Trimethylglycine 5.0
Xanthan gum 0.5
Carboxyvinyl polymer (1% aqueous solution pH 7.0 neutralized) 1.0
Polyacrylic acid amide 0.2
Hyaluronic acid 0.1
Glycerin 2.0
1,3-butylene glycol 2.0
1,2 pentanediol 2.0
Methyl paraoxybenzoate 0.2
Copolymer of formula (2) 1.0
Dipotassium glycyrrhizinate 0.5
1.0% hydrolyzed conchiolin aqueous solution 0.5

  When Examples 1 to 3 were used for one month, the amount of water in the keratin increased, the feeling of use was also moist and smooth, and there were many evaluations that it was a refreshing feeling of use. It has been found that the present invention has solved the problems of the present invention.

Claims (6)

  O oil obtained by emulsifying an oil phase containing meadowfoam oil, higher alcohol, petroleum jelly, oil-soluble N-long chain acyl acidic amino acid ester, and an aqueous phase containing trimethylglycine, water-soluble polymer and polyhydric alcohol with an emulsifier containing phospholipid. / W type emulsion   The O / W emulsion according to claim 1, wherein the water-soluble polymer is at least one selected from polyacrylamide, xanthan gum and hyaluronic acid.   Oil-soluble N-long chain acyl acidic amino acid esters include N-lauroyl-L-glutamate di (cholesteryl octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl 2-octyldodecyl), N-lauroyl-L- 3. The O / of claim 1 or 2, which is at least one selected from diglutamate (phytosteryl, behenyl, 2-octyldodecyl) and N-lauroyl-L-glutamate (cholesteryl, behenyl, octyldodecyl). W type emulsion   The proportion of the oil phase is 30 to 70% for Meadowfoam oil, 15 to 30% for higher alcohol, 6 to 15% for petroleum jelly, 3 to 10% for oil-soluble N-long chain acyl acidic amino acid ester, and the oil phase The O / W emulsion according to any one of claims 1 to 3, wherein the ratio to the whole composition is 10 to 30% of the O / W emulsion. Furthermore, the O / W type emulsion of Claim 1 thru | or 4 which mix | blended the copolymer of Formula (1).
  O / W type emulsion for hand creams according to claims 1 to 5.