JP2012158580A - Fungicide for oral cavity - Google Patents
Fungicide for oral cavity Download PDFInfo
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- JP2012158580A JP2012158580A JP2011035154A JP2011035154A JP2012158580A JP 2012158580 A JP2012158580 A JP 2012158580A JP 2011035154 A JP2011035154 A JP 2011035154A JP 2011035154 A JP2011035154 A JP 2011035154A JP 2012158580 A JP2012158580 A JP 2012158580A
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- JP
- Japan
- Prior art keywords
- oral cavity
- antioxidant
- citric acid
- weight
- cetylpyridinium chloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000000214 mouth Anatomy 0.000 title claims abstract description 13
- 230000000855 fungicidal effect Effects 0.000 title abstract 2
- 239000000417 fungicide Substances 0.000 title abstract 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 51
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 14
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 14
- 239000007864 aqueous solution Substances 0.000 claims abstract description 14
- 229960001927 cetylpyridinium chloride Drugs 0.000 claims abstract description 14
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims abstract description 14
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 claims description 14
- 235000006708 antioxidants Nutrition 0.000 claims description 13
- 239000003899 bactericide agent Substances 0.000 claims description 12
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 10
- 235000010323 ascorbic acid Nutrition 0.000 claims description 5
- 229960005070 ascorbic acid Drugs 0.000 claims description 5
- 239000011668 ascorbic acid Substances 0.000 claims description 5
- 239000000645 desinfectant Substances 0.000 claims description 4
- 229910052751 metal Inorganic materials 0.000 abstract description 10
- 239000002184 metal Substances 0.000 abstract description 10
- 230000000694 effects Effects 0.000 abstract description 8
- 150000002739 metals Chemical class 0.000 abstract description 3
- 238000005536 corrosion prevention Methods 0.000 abstract description 2
- 239000000463 material Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 230000002459 sustained effect Effects 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 description 9
- 241000894006 Bacteria Species 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- 238000005260 corrosion Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 241000193996 Streptococcus pyogenes Species 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 230000007797 corrosion Effects 0.000 description 2
- 208000002925 dental caries Diseases 0.000 description 2
- 238000007654 immersion Methods 0.000 description 2
- 230000003239 periodontal effect Effects 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- SPSPIUSUWPLVKD-UHFFFAOYSA-N 2,3-dibutyl-6-methylphenol Chemical compound CCCCC1=CC=C(C)C(O)=C1CCCC SPSPIUSUWPLVKD-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 208000007027 Oral Candidiasis Diseases 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 description 1
- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 1
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 1
- 235000005487 catechin Nutrition 0.000 description 1
- 229950001002 cianidanol Drugs 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 229960004337 hydroquinone Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 229940092258 rosemary extract Drugs 0.000 description 1
- 235000020748 rosemary extract Nutrition 0.000 description 1
- 239000001233 rosmarinus officinalis l. extract Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Landscapes
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
本発明は、クエン酸に塩化セチルピリジニウム及び酸化防止剤を配合した口腔用殺菌剤に関するものである。The present invention relates to a bactericidal agent for oral cavity in which cetylpyridinium chloride and an antioxidant are mixed with citric acid.
塩化セチルピリジニウムを配合した口腔用組成物が知られている。（特許文献１）また、金属の腐食を防止する成分を配合した抗菌剤や洗浄剤が提案されている（特許文献２〜５）An oral composition containing cetylpyridinium chloride is known. (Patent Literature 1) In addition, antibacterial agents and cleaning agents containing components that prevent corrosion of metals have been proposed (Patent Literatures 2 to 5).
口腔用の殺菌剤として、様々な菌に対して殺菌効果が持続し、さらに金属に対する優れた腐食防止効果を兼ね備えたものはなかった。 None of the bactericides for the oral cavity has a bactericidal effect against various bacteria and also has an excellent anti-corrosion effect on metals.
本発明は、クエン酸に塩化セチルピリジニウム及び酸化防止剤を配合することで、一般細菌類への殺菌・抗菌効果に加えて、化膿レンサ球菌、虫歯菌や歯周菌への持続性に優れた殺菌効果を実現し更に、歯科用金属義歯や金属補綴物に対する腐食（酸化）防止効果をも目的とするものである。 In the present invention, by adding cetylpyridinium chloride and an antioxidant to citric acid, in addition to bactericidal and antibacterial effects on general bacteria, it has excellent sustainability against Streptococcus pyogenes, caries and periodontal bacteria In addition to realizing a bactericidal effect, it also aims to prevent corrosion (oxidation) against dental metal dentures and metal prostheses.
本発明者らは、クエン酸に塩化セチルピリジニウム及び酸化防止剤を配合し、それをｐＨが２〜７の水溶液として使用することで、優れた効果が得られることを見出し、本発明を完成した。 The present inventors have found that an excellent effect can be obtained by blending citric acid with cetylpyridinium chloride and an antioxidant and using it as an aqueous solution having a pH of 2 to 7, and completed the present invention. .
即ち、本発明の口腔用殺菌剤はクエン酸１００重量部に酸化防止剤を５０〜１５０重量部と塩化セチルピリジニウムを０．５重量部以上配合してなる口腔用殺菌剤であり、また、その水溶液で、ｐＨが２〜７であることを特徴とする口腔用殺菌剤であり、また、ｐＨが２〜７のクエン酸と酸化防止剤の水溶液に塩化セチルピリジニウムを５０ｐｐｍ以上溶解してなる口腔用殺菌剤である。
さらに、酸化防止剤がアスコルビン酸及び／またはヒドロキノンである口腔用殺菌剤である。That is, the bactericidal agent for oral cavity according to the present invention is a bactericidal agent for oral cavity comprising 100 parts by weight of citric acid and 50 to 150 parts by weight of an antioxidant and 0.5 parts by weight or more of cetylpyridinium chloride. An oral bactericide characterized by an aqueous solution having a pH of 2 to 7, and an oral cavity formed by dissolving 50 ppm or more of cetylpyridinium chloride in an aqueous solution of citric acid and antioxidant having a pH of 2 to 7 It is a disinfectant.
Furthermore, it is an oral disinfectant whose antioxidant is ascorbic acid and / or hydroquinone.
上述したように本発明の口腔用殺菌剤は、クエン酸と塩化セチルピリジニウムに酸化防止剤を加えることで優れた効果を提供できる。As described above, the bactericidal agent for oral cavity of the present invention can provide an excellent effect by adding an antioxidant to citric acid and cetylpyridinium chloride.
本発明に係る口腔用殺菌剤は、クエン酸と酸化防止剤と塩化セチルピリジニウムを水に溶解して、ｐＨを２〜７の水溶液として使用する。The bactericidal agent for oral cavity according to the present invention dissolves citric acid, an antioxidant and cetylpyridinium chloride in water and uses it as an aqueous solution having a pH of 2 to 7.
本発明で用いる酸化防止剤としては、アスコルビン酸、トコフェロール、ヒドロキノン、ジブチルヒドロキシトルエン、ブチルヒドロキシアニソール、カテキン、ローズマリー抽出物等が使用可能であるが、アスコルビン酸とヒドロキノンが金属腐蝕防止効果に優れている。As the antioxidant used in the present invention, ascorbic acid, tocopherol, hydroquinone, dibutylhydroxytoluene, butylhydroxyanisole, catechin, rosemary extract, etc. can be used, but ascorbic acid and hydroquinone are excellent in metal corrosion prevention effect. ing.
水溶液中のクエン酸濃度は、通常０．０４重量％以上である。
クエン酸が０．０４重量％未満になると、十分な除菌効果の持続性を維持することができないからである。The citric acid concentration in the aqueous solution is usually 0.04% by weight or more.
This is because if the citric acid is less than 0.04% by weight, sufficient sterilization effect cannot be maintained.
水溶液のｐＨは、クエン酸の添加量を増やすと低下するが、クエン酸以外にリンゴ酸や酒石酸に代表される公知のヒドロキシカルボン酸類や酢酸に代表されるアルキルカルボン酸類を添加して調整することも可能である。また、これらのヒドロキシカルボン酸類やアルキルカルボン酸類のナトリウム塩やカリウム塩を添加することもできる。The pH of the aqueous solution decreases as the amount of citric acid added is increased, but it must be adjusted by adding known hydroxycarboxylic acids represented by malic acid and tartaric acid and alkylcarboxylic acids represented by acetic acid in addition to citric acid. Is also possible. Further, sodium salts and potassium salts of these hydroxycarboxylic acids and alkylcarboxylic acids can also be added.
水溶液中にはアルコールを含むことができる。その濃度は、例えばエタノール単体を除菌剤として使用する場合の濃度よりも低い値であっても十分に除菌効果を奏することができ、アルコール濃度は４０重量％未満に、より好ましくは３０重量％以下に調整されている。
アルコールとしては、除菌効果のあるエタノールやイソプロピルアルコールを用いることができる。The aqueous solution can contain an alcohol. Even if the concentration is a value lower than the concentration when, for example, ethanol alone is used as a disinfectant, the disinfection effect can be sufficiently obtained, and the alcohol concentration is less than 40% by weight, more preferably 30% by weight. % Is adjusted to below.
As the alcohol, ethanol or isopropyl alcohol having a sterilizing effect can be used.
以下、本発明の口腔用殺菌剤の効果を実施例に基づき説明する。Hereinafter, the effect of the bactericidal agent for oral cavity of the present invention will be described based on examples.
クエン酸１００重量部にヒドロキノン１００重量部と塩化セチルピリジニウム１０重量部を均一に混合し、本発明の実施例の混合物を得た。100 parts by weight of citric acid and 100 parts by weight of hydroquinone and 10 parts by weight of cetylpyridinium chloride were uniformly mixed to obtain a mixture of the examples of the present invention.
本発明の実施例の混合物を滅菌イオン交換水に溶解し、クエン酸濃度５０００ｐｐｍ、ヒドロキノン濃度５０００ｐｐｍ、塩化セチルピリジニウム濃度５００ｐｐｍの本発明の実施例の水溶液を得た。The mixture of the example of the present invention was dissolved in sterilized ion-exchanged water to obtain an aqueous solution of the example of the present invention having a citric acid concentration of 5000 ppm, a hydroquinone concentration of 5000 ppm, and a cetylpyridinium chloride concentration of 500 ppm.
本発明の実施例の水溶液を用いて、化膿レンサ球菌、虫歯菌、歯周菌、口内カンジダ菌に対して、定法により１４日間の抗菌試験を実施した。
いずれの菌も再現せず、長期間に亘る殺菌・抗菌効果の持続が確認された。Using the aqueous solution of the example of the present invention, antibacterial test for 14 days was carried out by a conventional method against Streptococcus pyogenes, caries bacteria, periodontal bacteria, and oral Candida bacteria.
None of the bacteria was reproduced, and it was confirmed that the bactericidal and antibacterial effect lasted for a long time.
金属義歯を本発明の実施例の水溶液に１４日間の浸漬試験を行った結果、金属義歯に色調的変化は全く認められなかった。The metal denture was subjected to a 14-day immersion test in the aqueous solution of the example of the present invention. As a result, no color change was observed in the metal denture.
滅菌イオン交換水を用いてクエン酸濃度５０００ｐｐｍ、塩化セチルピリジニウム濃度５００ｐｐｍの本発明の比較例の水溶液を得た。An aqueous solution of a comparative example of the present invention having a citric acid concentration of 5000 ppm and a cetylpyridinium chloride concentration of 500 ppm was obtained using sterilized ion-exchanged water.
金属義歯を本発明の比較例の水溶液に１４日間の浸漬試験を行った結果、金属義歯の表面に曇り（酸化物か水酸化）が認められた。As a result of the immersion test of the metal denture in the aqueous solution of the comparative example of the present invention for 14 days, clouding (oxide or hydroxide) was observed on the surface of the metal denture.
Claims (5)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011035154A JP2012158580A (en) | 2011-02-02 | 2011-02-02 | Fungicide for oral cavity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011035154A JP2012158580A (en) | 2011-02-02 | 2011-02-02 | Fungicide for oral cavity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2012158580A true JP2012158580A (en) | 2012-08-23 |
Family
ID=46839417
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011035154A Withdrawn JP2012158580A (en) | 2011-02-02 | 2011-02-02 | Fungicide for oral cavity |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2012158580A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014047180A (en) * | 2012-08-31 | 2014-03-17 | Separator System Kogyo Kk | Edible sterilization agent and edible sterilization agent set |
| US12083209B2 (en) | 2020-02-18 | 2024-09-10 | Sunstar Americas, Inc. | Oral care composition |
-
2011
- 2011-02-02 JP JP2011035154A patent/JP2012158580A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014047180A (en) * | 2012-08-31 | 2014-03-17 | Separator System Kogyo Kk | Edible sterilization agent and edible sterilization agent set |
| US12083209B2 (en) | 2020-02-18 | 2024-09-10 | Sunstar Americas, Inc. | Oral care composition |
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| Date | Code | Title | Description |
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| A300 | Withdrawal of application because of no request for examination |
Free format text: JAPANESE INTERMEDIATE CODE: A300 Effective date: 20140513 |