JP2012152412A - Biological light measuring apparatus - Google Patents

Abstract

A living body light measuring device capable of measuring brain activity on the inner surface of the cerebrum is provided. A plurality of light irradiators for irradiating light to a living body head and a living body passing through the living body head. A probe 25 that can be attached to a living body, and includes an optical receiver that detects light emitted from the surface, and an analysis unit that analyzes the distribution of received light based on a signal acquired from the measurement unit When the probe is mounted, the probe 25 has a shape in which one or a plurality of measuring instruments cover the cerebral column in the head of the living body and are arranged in the longitudinal direction of the cerebral column. .
[Selection] Figure 15

Description

  The present invention relates to a biological light measurement device that can easily measure deep brain activity.

  Local blood volume changes in the brain can be measured non-invasively by optical topography. In optical topography, the subject is irradiated with light having a wavelength in the visible to infrared range, and multiple signals that have passed through the subject are detected by the same photodetector, and the amount of hemoglobin change (or hemoglobin concentration and optical path) Measure the change in the product of the length). This method is characterized by low restraint on the subject compared to other brain function measurement techniques such as magnetic resonance lithography (MRI) and positron tomography (PET). Measurements of language function and neurological seizures are performed in clinical settings.

Japanese Patent Laid-Open No. 08-103434

Hidefumi Okada, et al. “Application of biological light propagation simulation to near-infrared spectroscopy”, Angiology, Vol. 49, 2009

    A biological optical measurement device that measures changes in blood volume associated with brain activity has already been published in Patent Document 1, and by determining the brain activity site on the surface of the cerebrum, only in the medical field such as mental illness and language function measurement It is widely used in humanities such as psychology and cognitive science.

  As shown in FIG. 2, the biological optical measurement device disclosed in Patent Document 1 is configured in a layered structure such as a scalp / skull 7, a cerebrospinal fluid layer (CSF layer) 8, a white matter / gray matter 9, and the like. A pair of light irradiators 10 (irradiation light sources, specifically, lasers, light emitting diodes, lamps, optical waveguides for guiding light emitted from these light sources, on the scalp of the head of the subject to be inspected, Specifically, the optical detector 11 that detects the light propagated in the living body and the optical fiber (specifically, an optical waveguide that detects the light propagated in the living body, specifically, the optical fiber and the like) An optical / electrical conversion element that converts the light detected by the optical waveguide into an electrical signal (specifically, a photodiode or a photomultiplier tube) is arranged to change blood volume in the cerebral cortex associated with brain activity. As a result, the intensity of light that propagates through the living body and reaches the detector changes. It is a technique for estimating a blood volume change. These light irradiators and photodetectors are arranged in pairs, and it is also possible to create an image of the blood volume change site by estimating the blood volume change from multiple points.

  However, the conventional biological light measurement device is intended to measure the brain activity on the white matter surface (cerebral cortex surface), in other words, on the outer surface (gaisokukyomen). In this measuring device, for example, it is possible to measure brain activity in a motor area, a language area, or the like corresponding to a Broadman brain map, and the results are measured in various non-patent documents. The reason why this measurement is possible has been studied by computer simulation or the like, and its grounds are shown in Non-Patent Document 1 and the like. This is because the light irradiated from the scalp surface is scattered by cells in the living tissue, but part of it is a cerebrospinal fluid layer (feature with a small light scattering coefficient) existing between the white matter and the skull. The light that propagates and is scattered by the cerebrospinal fluid layer passes through the white matter surface (cerebral cortex), and the detected light, including the passing light, reflects changes in the cerebral blood volume on the white matter surface. It is said that it is from. Moreover, according to this nonpatent literature 1, it is supposed that light does not propagate to deep parts, such as a cerebellum. For this reason, the shape of a measuring instrument that irradiates and receives light, the shape of a probe attached to the head of a subject, a calculation processing method, and the like have a structure that targets only measurement of the outer surface of the cerebrum. Therefore, it is not suitable for actively measuring human cognitive function information such as attention and decision making based on deep brain activity acquired from the inner surface of the brain.

  A probe that can be attached to a living body, comprising a measuring instrument that has a plurality of light irradiators that irradiate light on the head of the living body and a light receiver that detects light emitted from the surface of the living body through the head of the living body And an arithmetic unit that analyzes the distribution of the received light based on a signal acquired from the measurement unit, and the probe is configured to include one or a plurality of the measurement devices when the probe is mounted. Provides a biological light measurement device characterized by covering the upper part of the cerebral column in the living body head and having a shape arranged in a column in the longitudinal direction of the cerebral column.

  The living body optical measurement device of the present invention makes it possible to measure brain activity on the inner surface, which is the boundary surface with the cerebral column existing between the left and right hemispheres. As a result, measurement of human cognitive functions such as attention and decision making Is now possible.

Diagram showing the measurement of brain activity on the inner surface of the cerebrum The figure which showed the device composition of the conventional living body light measuring device typically A top-down view of the cerebrum located inside the skull Light propagation path on the inner surface of the right hemisphere (1) Model used for computer simulation (a) Simulation calculation result 1 (b) Light visualization characteristics table Diagram showing differences in light propagation characteristics with and without cerebral columns Modification 1 of FIG. Model diagram used to verify differences in light propagation characteristics with and without cerebral columns Simulation calculation result 2 Modification 2 of FIG. Diagram showing correlation between multiple photodetector-light illuminator pairs Probe Figure 1 Probe Figure 2 Overall configuration diagram of biological light measurement device Probe array configuration diagram 1 Probe array configuration diagram 2 An example of analysis contents in the signal analysis unit 32 Diagram showing the difference in propagation path in the depth direction where light propagates Diagram showing the case of irradiation directly above and near the cerebral column The figure which showed the case where it measures in combination with another part measuring instrument Formula for calculating absorbance change ΔA

  The principle for carrying out the present invention will be described with reference to FIG. FIG. 1 is a diagram schematically showing a brain measurement site according to the present invention. Reference numeral 1 denotes a scalp / skull of the head structure, 2 denotes a cerebrospinal fluid layer, and 3 denotes a white matter / gray matter layer. This 3 is divided into right and left by the cerebral column 4, 3-1 indicates the left hemisphere, and 3-2 indicates the right hemisphere.

  The configuration shown in FIG. 1 has a light irradiator 5 and a photodetector 6 arranged along the cerebral cerebral column 4 as compared with the case of measuring the front side of the brain as shown in FIG. ing.

  The arrangement positions of the light irradiator 5 and the light detector 6 will be described in more detail with reference to FIGS. FIG. 3 is a picture of the cerebrum located inside the skull as seen from the top of the head. In the figure, 3-1 indicates the left hemisphere, and 3-2 indicates the right hemisphere. The left hemisphere and the right hemisphere exist separately, and the arrangement positions of the light irradiator 5 and the photodetector 6 in FIG. 1 are located immediately above the middle of these left and right hemispheres. FIG. 4 also shows the inner surface of the right hemisphere. 12 and 13 respectively model the cerebrum and cerebellum. Reference numeral 14 denotes a propagation path of light irradiated from the light irradiator 5 and reaching the photodetector, and shows a state in which light propagates on the inner surface of the cerebrum.

  In order to confirm the effectiveness of the measurement method shown in FIG. 1, it was carried out by computer simulation. The method and result will be described below. FIG. 5 shows a model used for computer simulation. 1 has the same structure as the brain structure described in FIG. 1. In the upper diagram of FIG. 5, the arrangement positions of the light irradiator 5 and the light detector 6 are respectively (x, y, z) = (− 15, 0, 50), (x, y, z) = (15, 0, 50), and a pair of light emitters and light detectors are arranged at 30 mm intervals.

  On the other hand, the lower diagram of FIG. 5 shows the tomographic structure on the X = 0 plane indicated by 1-1 'in the upper diagram of the figure. The width of the cerebral column 4 was w mm. Here, FIG. 12A is the position of the brain activity site, and is assumed to exist at a position of a depth D mm from the cerebrospinal fluid layer 2. It was also assumed that the absorption coefficient changes with brain activity at this location. In order to evaluate the light propagation characteristics when the cerebral column 4 is present and not present, the case of w = 2 and w = 0 is set, and the light scattering coefficient and the light absorption coefficient shown in Table 1 are calculated. Set for. For the set coefficient, the non-patent document “2002 Phys. Med. Biol. 47 3429“ Arranging optical fibers for the spatial resolution improvement of topographical images ”” was referred to.

  A specific method of simulation is described below. First, the propagation path of the light irradiated from the light irradiator and reaching the light detector was calculated by Monte Carlo simulation and using the converted scattering coefficient shown in FIG. 6 (b). Next, using the absorption coefficient shown in FIG. 6 (b), the intensity of light reaching the photodetector for each photon is calculated before and after brain activity, and the sum of the results for each photon is calculated. Asked. From the sum, the detected light intensity before brain activity was defined as T1, the detected light intensity after brain activity was defined as T2, and the absorbance change ΔA was calculated using the formula shown in FIG.

  This ΔA was calculated for w = 2 mm and w = 0 mm, and the possibility of measurement on the inner surface of the cerebrum depending on the presence or absence of the cerebral column 4 was evaluated.

  FIG. 6A shows the calculation result. This calculation result shows the relationship between the change in absorbance (ΔA) and D with respect to w = 0 mm and w = 2 mm. In each D, when comparing changes in absorbance (ΔA), ΔA is larger for w = 2 mm than for w = 0 mm. As a result, the sensitivity of the inner surface of the cerebrum is high or improved when the cerebral column 4 exists and the cerebral column 4 is provided with the light irradiator 5 and the photodetector 6 to measure the brain activity. Is shown.

  FIG. 7 shows a table visualizing the internal light propagation characteristics when the presence or absence of the cerebral column 4 is set, that is, when w = 0 mm and w = 2 mm, respectively. In this coordinate system shown in FIG. 5, the light propagation path inside the calculation region is visualized from the x = 35 plane, in other words, a perspective view. Comparing the case where there is no cerebral column 4 (w = 0mm) and the case where cerebral column 4 is present (w = 2mm), it becomes clear that light is propagated along the cerebral column 4 to the deep part. It was. From this result, it can be seen that when the cerebral column 4 is present, the light propagates along the cerebral column 4, and thus the sensitivity to the brain activity on the inner surfaces of the left and right hemispheres is high.

  Next, examples of simultaneous measurement with a plurality of light irradiator-photodetector pairs in the same model are shown in FIG. In the example shown in FIG. 8, a pair of the light irradiator 5 and the light detector 6 is disposed at the top of the cerebral column 4, and light irradiators 15 and 16 and light detectors 17 and 18 are separately disposed around the pair. ing. In order to verify the difference in the light propagation characteristics depending on the presence or absence of cerebral tandem in the same model, as shown in FIG. 9, the photons emitted from the light irradiator 5 and reaching the light detector 6, and the light The difference in the propagation characteristics of photons irradiated from the irradiator 16 and reaching the photodetector 18 was calculated from the calculation results. The calculation results are shown in FIG. The amount of light detected differs depending on the arrangement position of the light irradiator and the light detector, and when the pulse is irradiated from the light irradiator, the shape of the pulse waveform detected by the light detectors 6 and 18 may be different. It was revealed. This result shows that the light propagation path is different between the case where the light irradiator-photodetector pair is arranged on the cerebral column 4 and the case where the light irradiator-photodetector pair is arranged not on the cerebral column 4. It is shown that.

  As a result of FIG. 10, it is possible to estimate the light irradiator-photodetector pair arranged on the cerebral column 4 by arranging a plurality of light irradiator-photodetector pairs around the cerebral column 4. It shows that it becomes. In general, since the cerebral column 4 exists inside the skull, in order to estimate the position of the cerebral column 4 non-invasively from above the scalp, a non-invasive morphological image measurement apparatus such as a magnetic resonance drawing apparatus (MRI) is used. There is no other way but to use. However, from the result shown in FIG. 10, it is possible to estimate the light illuminator-photodetector pair closest to the cerebral column 4, and the possibility of detecting light passing through the deep cerebrum. It is possible to estimate a light irradiator-photodetector pair having a high value. Second, as described in the first section, “A light irradiator-photodetector pair that has a high possibility of detecting light passing through the deep part of the cerebrum” and “Detecting light passing through the outer surface of the cerebrum. Comparison with the "light irradiator-photodetector pair" is possible. As a result, it is possible to obtain a correlation between brain activity on the inner and outer surfaces of the cerebrum, so new knowledge of brain activity that could not be obtained only by acquiring brain activity on the inner surface was obtained. Is possible.

  Further, in FIG. 11, the light irradiator and the light detector are arranged in the order of the light irradiator 19, the light irradiator 20, the light detector 21, and the light detector 22. The effect of this arrangement will be described with reference to FIG. FIG. 12 shows the inner surface of the right hemisphere of the cerebrum. As shown in FIG. 12, the light propagation path 23 by the light irradiator 19-photodetector 21 and the light propagation path 24 by the light irradiator 20-photodetector 22 partially overlap on the inner surface of the cerebrum. I understood that. From this result, the brain activity on the inner surface can be measured at multiple points by the light irradiator-photodetector arrangement method shown in FIG.

  An example of the probe 25 for carrying out the present invention is shown in FIG. In order to measure the cerebral column, when the probe 25 is mounted, it is necessary to have a structure in which the measuring device 26 is securely mounted on the cerebral column. Furthermore, the cerebral column is located at the cleft of the right hemisphere and the left hemisphere of the brain, and has a vertically long shape from the forehead to the back of the head. Therefore, it is desirable that the light irradiator and the light detector, or the module with the light irradiator and the light detector, have a structure that is arranged in tandem along the cerebral tandem.

  When the probe 25 is mounted on the top of the subject, the probe 25 is configured to be arranged in a row with measuring instruments 26 composed of a light irradiator and a photodetector so as to cover the cerebral column. By adopting such a structure, the light irradiator and the photodetector can be surely arranged on the cerebral tandem, and information specific to deep brain activity acquired from the inner side of the brain is actively acquired. be able to.

  Furthermore, by arranging the measuring instruments 26 in a column and using only the cerebral column as a target of the measurement site, it is possible to reduce the impossibility of arithmetic processing due to the extraction of excess information from other parts, and to manufacture a probe. Cost can also be reduced.

  The tip of the probe 25 is provided with a fixing mechanism 27 in the vicinity of the forehead in the front and in the vicinity of the back of the head and the neck, and is fixed to the head.

  You may provide the belt member 28 so that it may wind around a head like FIG. By providing the belt member 28, the subject can mount the probe more stably. Furthermore, it also plays a role of assisting that the measuring instrument 26 is reliably mounted on the top of the subject, thereby improving the measurement accuracy. There may be a single or a plurality of light irradiator-photodetector pairs provided in the measuring instrument 28. The specific configuration of the measuring device 26 using a light irradiator and a light detector will be described later.

  Next, the system of this apparatus will be described with reference to FIG. However, it should be noted that this system is only an example for carrying out the present invention, and does not limit the technical scope of the present invention.

  The apparatus includes a probe 25, a lock-in up 29, an analog-digital conversion 30 (hereinafter referred to as “A / D converter 30”), a calculation unit 31, a signal analysis unit 32 included in the calculation unit 31, It comprises a storage device 33, a light quantity controller 34, and a light irradiator-photodetector distance controller 35.

  With this system, the measuring instrument 26 composed of a light irradiator and a light detector irradiates the subject's head with light having a wavelength belonging to the visible to infrared region, and receives a plurality of signals of light that have passed through the subject. Information based on the activity of the brain contained in the brain blood is obtained by detecting and measuring with a photodetector.

  The measuring device 26 detects light reflected inside the subject and converts it into an electrical signal. As the optical receiver, a photoelectric conversion element typified by a photomultiplier tube or a photodiode is used. Electric signals representing the intensity of light passing through the living body photoelectrically converted by the optical receiver are respectively input to the lock-in amplifier 29.

  The transmitted light intensity signal of each wavelength output by the lock-in process by the lock-in up 29 is analog-digital converted by the A / D converter 30 and then sent to the calculation unit 31. In the calculation unit 31, the signal analysis unit 32 in the calculation unit 31 uses the passing light intensity signal to detect relative changes in the oxygenated hemoglobin concentration, the deoxygenated hemoglobin concentration, and the total hemoglobin concentration from the detection signal at each detection point ( Or more precisely, the amount of change in the product of each hemoglobin concentration and optical path length) is calculated and stored in the storage device 33 as time-dependent information of a plurality of measurement points.

  Although an example in which analog-to-digital conversion is performed after lock-in processing is described here, lock-in processing can also be performed digitally after amplifying and analog-to-digital conversion of the signal from the optical receiver. is there.

  In addition, although an embodiment in which a plurality of lights are separated by a modulation method has been described here, the present invention is not limited to this. For example, time division for discriminating a plurality of lights by shifting the timing of irradiating the plurality of lights in time. It is also possible to use a method.

  The signal analysis unit 32 in the calculation unit 31 analyzes the characteristics of the acquired signal and the like by a program stored in the storage device 33. The signal analysis unit 32 compares the light intensity determined to be a cerebral column set based on FIG. 10 and the like to determine whether the light is transmitted on the cerebral column, that is, the inner side of the brain. Then, information by the light irradiator-photodetector pair determined to be on the cerebral column by the determination is acquired as information on the inner side of the brain.

  In this way, information specific to activities in the deep brain acquired from the inner part of the brain by using the probe shape, measuring instrument structure, calculation method, etc. specialized for acquiring information on the inner part of the brain Can be obtained.

  As a method for further improving the accuracy of acquiring information based on the inner side of the brain according to the present embodiment, the measuring instrument 26 includes a plurality of light irradiators, and a prescan for identifying measuring instruments existing on the cerebral tandem It is effective to add functions to the measurement process.

  FIG. 16 shows an example of the configuration of the probe array 36 by the measuring instrument 26 for specifying the corresponding light irradiator-photodetector pair on the cerebral column. Dashed line 1 is the position of the cerebral column. Furthermore, an irradiation measuring instrument 37 composed of only a light irradiator and a light receiving measuring instrument 38 composed of only a photodetector are shown. In the present embodiment, each of the irradiation measuring instrument 37 and the light receiving measuring instrument 38 includes five light irradiators 5 and five photodetectors 6, but the number is not limited thereto. In general, it is impossible to find the position of the cerebral column from above the scalp. In this embodiment, the irradiation measuring device 37 and the light receiving measuring device 38 located at the center of the array are positioned on the cerebral column. Assume that

  In the probe array 36, as shown in FIG. 17, the optical receiver 6 may be arranged at the center of each measuring instrument 26, and a plurality of light irradiators 5 may be arranged in the periphery to constitute an array of the measuring instruments 26. . With this configuration, it is possible to identify the light irradiator corresponding to each measurement point even if it is inflected due to individual differences, such as the cerebral tandem indicated by the wavy line 1, so that the shape of the cerebral tandem is not dependent on individual differences. It becomes possible to measure along.

  The probe array 36 is specified by pre-scanning as a movable mechanism that can change the distance between the light irradiator and the light detector in order to extract information on the inner side of the brain with higher accuracy. In the light irradiator-photodetector pair on the cerebral column, the optimal light intensity and waveform characteristics can be clearly extracted. You may enable it to control by the control part 35. FIG. In addition, after the illuminator-photodetector on the cerebral tandem is identified, the identified illuminator-photodetector can be replaced with a suitable illuminator-photodetector module for cerebral tandem measurement. An interchangeable mechanism may be provided so that the distance between the light irradiator and the light detector can be changed by exchanging the light irradiator and the light detector installed in the measuring instrument 26.

  Next, using FIG. 15 and FIG. 18, a pre-scan calculation method for identifying a corresponding light irradiator-photodetector pair on the cerebral column will be described.

  FIG. 18 shows an example of analysis contents. The signal analysis unit 32 analyzes the light amount of the acquired signal and the received light receiver, determines whether the light is transmitted through the cerebral column, that is, the inner part of the brain, and the determined light irradiator Is identified as a light illuminator located on the cerebral column.

  Unlike the prior art that measures the surface of the brain, the present invention has the characteristic of measuring the inner surface of the brain, so that the light intensity is reduced as the light is irradiated to the deep layer of the brain and received. Therefore, the light from the specified light irradiator is attenuated as compared with the light from the other light irradiators, so the specified light is based on the analysis result such as “light quantity control” in FIG. The amount of light from the irradiator is increased compared to the light intensity of light from other light irradiators. Alternatively, a reference light intensity may be set in advance, and the light amount may be controlled so as to be close to the reference value.

  In this way, the noise level of the detected light intensity can be made uniform, and signals on the cerebral tandem can be acquired with high accuracy. Moreover, when performing the said light quantity control, you may attenuate or light-extinguish the light quantity from light irradiation devices other than the specified light irradiation device. With this control, it is possible to reduce the processing load and suppress errors due to noise.

  The signal analysis unit acquires information based on the identified light irradiator-photodetector pair as information on the inner side of the brain as information on the cerebral column.

  By providing such a pre-scan function, it is possible to more accurately acquire information specific to deep brain activity acquired from the inner side of the brain, which is the first object of the present invention.

  Further, as shown in FIG. 19, a difference occurs depending on a site where light is transmitted through the inner side of the brain depending on a measured signal. That is, since the information derived from the characteristics of the obtained brain is different, it is necessary to estimate which part of the brain each light has transmitted from the light intensity or the like.

  FIG. 19 shows a case where a plurality of distances between the light irradiator and the light detector are set in the case of measuring in the depth direction, and different depth information is measured by paying attention to the fact that the light propagation path is different depending on this setting. The schematic diagram is shown. In this figure, the light propagation path of each pair (3 pairs) is different, and the decrease in light intensity passing between 5-1 and 6-1 is the light intensity passing between 5-3 and 6-3. Large compared to the decrease. For this reason, when the same light intensity is irradiated at three points, the light intensity detected at 6-1 is minimized. Therefore, by comparing the light intensity from the minimum light intensity to the vicinity of the brain surface, etc., the position in the depth direction of the brain that each light illuminator has transmitted is determined from the degree of the light intensity attenuation rate. It can be estimated and measured.

  The signal analysis unit 32 in the calculation unit 31 in FIG. 15 classifies the depth level according to the amount of light as shown in the analysis content in FIG. 18, and determines which depth information is received in the depth direction of the brain. Estimate whether you have it. By specifying the measurement site in the inner side of the brain based on the estimation result, it becomes possible to more clearly acquire information specific to the activity of the deep brain acquired from the inner side of the brain.

  The information directly above the cerebral column may be obtained by combining the information of the right brain and the left brain. Therefore, from the correlation between the light illuminator specified by the previous examples and the information acquired from the adjacent light illuminator, the left and right brain information about the difference in left and right brain activity and information on the cerebral tandem The correlation with can be measured.

  FIG. 20 is a biological light measurement device comprising a plurality of pairs of light irradiators and light detector pairs on and near the cerebral tandem. In FIG. 20, since the probes 25 are arranged on the boundary surface of the left brain, the cerebral column, and the boundary surface of the right brain, the light propagation paths are different. The characteristics of the obtained signals are analyzed for similarity and correlation by a difference in waveform characteristics by the calculation unit 31 and comparison with a reference waveform in the memory.

As a result, regarding the activity on the cerebral cortex along the cerebral tandem, it is possible to measure the difference in brain activity in the left and right hemispheres.
Furthermore, by acquiring information on the front surface and the inner part at the same measurement target part of the brain at the same time, it becomes possible to analyze the information on the brain activity of the target part in more detail. FIG. 21 shows a configuration integrated with an outer surface measuring instrument 39 that measures the surface of the brain other than on the cerebral tandem. If the said structure is used, it will become possible to measure the same measurement site | part of a brain from both the surface and an inner part. By comparing the correlation between the obtained information from the surface of the same measurement site and the information from the inner side, the information on the measurement site can be detected with higher accuracy.

1 scalp / skull 2 cerebrospinal fluid layer 3 gray matter / white matter 3-1 left hemisphere 3-2 right hemisphere 4 cerebral tandem 5 light irradiator 6 light detector 7 scalp / skull 8 cerebrospinal fluid layer (CSF layer)
9 White matter / gray matter 10 Light irradiator 11 Light detector 12 Cerebrum 12-1 Location of brain active site 13 Cerebellum 14 Light propagation path from light irradiator and reaching light detector 15 Light irradiator 16 Light irradiation Device 17 Light detector 18 Light detector 19 Light irradiator 20 Light irradiator 21 Light detector 22 Light detector 23 Light propagation path 24 by light irradiator 19 and light detector 21 By light irradiator 20 and light detector 22 Light propagation path 25 Probe 26 Measuring instrument 27 Fixing mechanism 28 Belt member 29 Lock-in amplifier 30 A / D converter 31 Calculation unit 32 Signal analysis unit 33 Storage device 34 Light quantity control unit 35 Light irradiation device-photodetector distance control unit 36 Probe array 37 Irradiation measuring instrument 38 Light receiving measuring instrument 39 External surface measuring instrument

Claims (12)

A plurality of light irradiators that irradiate light on the head of the living body;
A light receiver that detects light emitted from the surface of the living body through the living body head;
A probe that can be attached to a living body,
Based on a signal acquired from the measurement unit, a calculation unit that analyzes the distribution of the received light,
Have
The probe is
When the probe is mounted, one or a plurality of the measuring instruments cover a cerebral column in the living body head and have a shape arranged in tandem in the longitudinal direction of the cerebral column Measuring device. A plurality of light irradiators for irradiating light on the surface of the living body;
A light receiver that detects light emitted from the surface of the living body through the inside of the living body;
A probe comprising:
Based on a signal acquired from the photodetector, an arithmetic unit that analyzes the distribution of the received light;
Have
The probe is
The biological light measurement device, wherein the plurality of light irradiators and the plurality of light receivers are arranged on a substantially straight line intersecting a midpoint of the probe. The computing unit is
The one or a plurality of the light irradiators that receive the light irradiated to the cerebral tandem among the plurality of the light irradiators included in the one or a plurality of measuring devices are specified. Biological light measuring device. The computing unit is
The living body light measuring device according to claim 2, wherein when the amount of light received is lower than a predetermined value, the light irradiated to the cerebral tandem is specified as a light irradiator. The computing unit is
The biological light measurement device according to claim 4, wherein the light intensity of the light to be irradiated is changed based on a measurement result in the specified light irradiator. The computing unit is
The biological light measurement device according to claim 3, wherein the light intensity irradiated by one or a plurality of the light irradiators other than the specified light irradiator is made smaller than a predetermined value. The computing unit is
Obtaining a signal based on light from one or more of the light illuminators adjacent to the identified light illuminator;
The biological light according to claim 3, wherein a correlation between a signal based on light from the identified light irradiator and a signal based on light from the one or more adjacent light irradiators is analyzed. Measuring device. The computing unit is
4. The biological light measurement apparatus according to claim 3, wherein the irradiation position of the light in the depth direction of the inner side of the brain is analyzed based on a measurement result of a measuring instrument that receives light irradiated to the cerebral tandem. . The probe is
The living body light measurement apparatus according to claim 1, further comprising a belt member attached to and detached from the head of the sample. The computing unit is
The optical measurement apparatus according to claim 3, wherein an interval between the specified light irradiator and the light receiver is changed based on light intensity of light from the specified light irradiator. The measuring instrument is
4. A mechanism for exchanging a part of the plurality of light irradiators or light detectors of the measuring instrument and changing a distance between the light irradiators and the light detectors. Biological light measuring device. The probe is
When the probe is attached, it has an outer surface measuring instrument that measures a part measured by the measuring unit from a side surface different from the side surface on which the measuring unit is installed,
The computing unit is
The biological light measurement apparatus according to claim 1, wherein the distribution of the received light is analyzed based on a correlation between the measurement device and a signal from the outer surface measurement device in the same part of the brain.