JP2012131076A - Production process of medical bag and medical bag - Google Patents

Abstract

A method for manufacturing a medical bag and a medical bag capable of preventing peeling of a display pattern printed on a sheet material are provided.
In the method for producing a medical bag of the present invention, a sheet material 21 made of a resin mainly composed of polypropylene, having a Young's modulus of 100 to 250 MPa, and a water contact angle of 70 to 90 ° is prepared. The surface of the part of the sheet material 21 to be printed is subjected to corona discharge treatment, the part of the sheet material 21 subjected to the corona discharge treatment is printed using ultraviolet curable ink, and the printed ink is irradiated with ultraviolet rays. The ink is cured. Then, the sheet material 21 is cut for each bag body, the discharge port is fused to the cut back body, and the first space and the second space are filled with liquid, respectively.
[Selection] Figure 2

Description

  The present invention relates to a method for manufacturing a medical bag and a medical bag.

  As a medical bag, a bag in which a liquid such as an infusion solution or a peritoneal dialysis solution is sealed by fusing a resinous sheet material is known (for example, see Patent Document 1). The sheet material is fused by sandwiching and heating the upper and lower open ends of the cylindrical sheet material with a pair of seal dies.

  In addition, various display patterns are printed on the surface of the fused sheet material before the liquid is stored. For this printing, a hydrophobic ink, specifically, an ultraviolet curable ink is used. Note that the medical bag with the liquid sealed inside is packaged and then subjected to high-pressure steam sterilization.

  However, the conventional method for manufacturing a medical bag has a problem that a display pattern printed on a sheet material is peeled off during high-pressure steam sterilization.

JP 2004-208883 A

  The objective of this invention is providing the manufacturing method and medical bag of a medical bag which can prevent peeling of the display pattern printed on the sheet | seat material.

Such an object is achieved by the present inventions (1) to (10) below.
(1) A method for producing a medical bag using a sheet material,
A sheet material composed of a resin mainly composed of polypropylene, having a Young's modulus of 100 to 250 MPa, and a water contact angle of 70 to 90 ° is prepared.
Perform discharge treatment on the surface of the part to be printed on the sheet material,
Printing using ultraviolet curable ink on the discharge treated portion of the sheet material,
A method for producing a medical bag, wherein the ink after printing is irradiated with ultraviolet rays to cure the ink.

  (2) The manufacturing method of the medical bag as described in said (1) whose content rate of the said polypropylene in the constituent material of the said sheet | seat material is more than 50 wt%.

  (3) The said discharge process is a manufacturing method of the medical bag as described in said (1) or (2) which is a corona discharge process.

  (4) The method for manufacturing a medical bag according to any one of (1) to (3), wherein in the discharge treatment, a frequency of a voltage applied between electrodes for generating discharge is 20 to 50 kHz.

  (5) In the said discharge process, the distance between the electrode which produces discharge, and the said sheet | seat material is 2-10 mm, The manufacturing method of the medical bag in any one of said (1) thru | or (4) .

  (6) The above-described (1) to (5), in which the discharge treatment is performed while relatively moving the sheet material and the electrode that generates discharge at a speed of 350 to 450 mm / second. A method for manufacturing a medical bag.

  (7) The method for producing a medical bag according to any one of (1) to (6), wherein the irradiation energy of the ultraviolet rays is 4.8 to 6.0 kW.

  (8) The method for producing a medical bag according to any one of (1) to (7), wherein the ultraviolet ray is irradiated while moving the sheet material at a speed of 350 to 450 mm / sec.

  (9) The method for manufacturing a medical bag according to any one of (1) to (8), wherein the printing is letterpress printing.

  (10) A medical bag manufactured by the method for manufacturing a medical bag according to any one of (1) to (9).

  According to the present invention, since the discharge treatment is performed on the surface of the part to be printed with the sheet material, the wettability of the surface of the part to be printed with the sheet material is improved, thereby the display pattern printed on the sheet material. Can be prevented.

It is a front view which shows the structural example of the medical bag manufactured by the manufacturing method of the medical bag of this invention. It is a figure which shows the structural example of the apparatus used for the manufacturing method of the medical bag of this invention.

  Hereinafter, the manufacturing method and medical bag of the medical bag of this invention are demonstrated in detail based on suitable embodiment shown to an accompanying drawing.

  FIG. 1 is a front view showing a configuration example of a medical bag manufactured by the method for manufacturing a medical bag of the present invention, and FIG. 2 shows a configuration example of an apparatus used in the method for manufacturing the medical bag of the present invention. FIG. In the following description, the upper side in FIG. 1 is referred to as a “base end” and the lower side is referred to as a “tip”.

  As shown in these drawings, the medical bag 1 includes a bag body 2 and a discharge port 6, and the bag body 2 is filled with a liquid. The medical bag 1 may be a multi-chamber container in which the interior of the bag body 2 is defined in a plurality of spaces, or a single-chamber container having one space. In the present embodiment, a case where the multi-chamber container, that is, the bag main body 2 has a first space 3 and a second space 4 for storing a liquid therein will be described as an example.

  The bag body 2 is manufactured using a sheet material 21 described later made of a flexible soft material that is molded into a cylindrical shape by an inflation molding method. In addition, as will be described later, the sheet material 21 is for a plurality of bag main bodies, and is used by being cut for each bag main body, but in the following, before and after cutting the sheet material 21 Is also referred to as “sheet material 21”.

  The bag body 2 is formed into a bag shape by sealing both ends of the sheet material 21 by fusion or adhesion such as heat fusion or high frequency fusion. The proximal end side seal portion 22 and the distal end side seal portion 23 of the bag body 2 are each cut into a desired shape.

  A hole 24 that is used when the medical bag 1 is suspended from a hanger or the like is provided at a substantially central portion of the seal portion 22 on the proximal end side of the bag body 2.

  A partition portion 5 is formed in the middle of the bag body 2 in the vertical direction in FIG. 1, and the interior of the bag body 2 is divided into a first space 3 and a second space 4 by the partition portion 5. It is partitioned. The first space 3 and the second space 4 contain liquids 30 and 40 having different compositions, respectively. In this case, the liquid 30 and the liquid 40 are such that their components easily react with each other, such as a glucose infusion preparation and an amino acid infusion preparation.

  Until use, the liquid 30 and the liquid 40 are stored separately without mixing, and in use, the partition 5 is peeled off to allow the first space 3 and the second space 4 to communicate with each other. Mix liquid 40. Thereby, alteration, deterioration, etc. of the liquids 30 and 40 can be prevented, and the intended medicinal effect can be obtained more reliably.

  In addition, by storing a liquid that requires pH adjustment, for example, a peritoneal dialysis solution and a pH adjusting agent that neutralizes the liquid separately, that is, in each of the first space 3 and the second space 4, Such liquid alteration, decomposition, deterioration, coloring, discoloration, generation of precipitates and the like can be prevented.

  In the present invention, the liquids 30 and 40 are not particularly limited, and examples thereof include peritoneal dialysis solution physiological saline, electrolyte solution, Ringer's solution, high-calorie infusion solution, glucose solution, water for injection, and oral nutrient.

  The partition part 5 is obtained by fusing or bonding the sheet material 21 of the bag body 2 in a band shape. This partition part 5 is comprised by the weak seal part of the grade which peels by pressing the part by the side of the 1st space 3 or the 2nd space 4 of the bag main body 2 by hand, and raising the internal pressure, for example. Thereby, the interruption | blocking by the partition part 5 is cancelled | released by simple operation | work, without using a special instrument etc., and the liquid in the 1st space 3 and the 2nd space 4 can be mixed.

  In addition, it is not restricted to the case where all the partition parts 5 are comprised by the weak seal part, A part of partition part 5 may be comprised by the weak seal part. Further, for example, a difference in the peel strength may be provided by a method such as providing a difference in the width of the band of the partition portion 5, and a portion that is easily peeled and a portion that is difficult to peel may be provided.

  In addition, on the surface of a predetermined portion of the bag body 2, for example, a predetermined display pattern such as a scale, a volume, a drug concentration, a product type, a warning statement, a component list, and an expiration date is printed.

  A discharge port 6 is provided at the front end of the bag body 2. The discharge port 6 has a function of discharging at least the mixed liquid of the liquid 30 and the liquid 40, and includes a discharge port main body 61 provided with an elastic plug, an outer cylinder 62 installed outside the discharge port main body 61, It has.

  The outer cylinder 62 is sandwiched between the sheet materials 21 and 21 at the seal portion 23 at the tip of the bag body 2 and is fixed by the seal portion 23. Bondability and adhesion between the outer cylinder 62 and the sheet material 21 are high, and liquid leakage and the like can be reliably prevented.

  The discharge port 6 may function as a mixed injection port for injecting the liquid 40. A plurality of such outlets may be installed.

  Further, the sheet material 21 is not limited to the inflation molding method, and examples thereof include a T die method, a blow molding method, a dry lamination method, a hot melt lamination method, a coextrusion inflation method, a coextrusion T die method, and a hot press method. It may be produced by various methods.

  Further, in order to effectively prevent deterioration and deterioration of the liquids 30 and 40, the sheet material 21 is preferably one having as low a gas permeability as possible, that is, one having a gas barrier property.

  As a constituent material of the sheet material 21, it is preferable to use a resin mainly composed of polyolefin, particularly polypropylene. This is because the constituent material has heat resistance and water resistance that can withstand high-pressure steam sterilization (autoclave sterilization).

  When polypropylene is the main component, the content of polypropylene in the constituent material of the sheet material 21 is preferably more than 50 wt%, more preferably about 60 to 95 wt%, and about 70 to 80 wt%. More preferably.

  Moreover, although the average molecular weight Mw of the polypropylene used is not specifically limited, It is preferable that it is about 800,000-3 million.

  Specifically, as the constituent material of the sheet material 21, for example, only polypropylene, a copolymer of polypropylene and one or more other polymers, polypropylene and one or more other polymers And a mixture of polypropylene and one or more other polymers.

  Examples of the other polymer include thermoplastic resins such as polyethylene, EVA, polyamide, and polyester, and thermoplastic elastomers described later. One or more of these can be used in combination. .

  Further, as a particularly preferable constituent material of the sheet material 21, a soft resin softened by blending polypropylene with a thermoplastic elastomer such as styrene, polyamide, or polyester can be exemplified. As the thermoplastic elastomer, for example, a styrene-based thermoplastic elastomer such as a styrene-butadiene copolymer or a styrene-ethylene-butylene-styrene block copolymer is preferable. This is because this material has high strength and high flexibility, high heat resistance, particularly high heat resistance during sterilization, high water resistance, excellent workability, and reduction in manufacturing cost.

  In addition, it is preferable that the content rate of the thermoplastic elastomer in the constituent material of the sheet | seat material 21 is about 0-49 wt%, and it is more preferable that it is about 10-40 wt%.

Next, a method for manufacturing the medical bag 1 will be described.
[1]
A sheet material 21 is prepared which is molded into a tubular shape by an inflation molding method and in which a predetermined portion is sealed. The sheet material 21 is for a plurality of bag main bodies, and is used by being cut for each bag main body in a process described later.

  As described above, the sheet material 21 is made of a resin whose main component is polypropylene. In addition, since it has already demonstrated about the constituent material of the sheet | seat material 21, the description is abbreviate | omitted.

  The Young's modulus of the sheet material 21 at room temperature (20 to 30 ° C.) is about 100 to 250 MPa, and preferably about 170 to 240 MPa. When the Young's modulus exceeds the upper limit value, the flexibility of the sheet material 21 is reduced, and when it is less than the lower limit, the display pattern printed on the sheet material 21 is easily peeled off.

  Moreover, the contact angle of water at room temperature (20 to 30 ° C.) of the sheet material 21 is about 70 to 90 °, and preferably about 80 to 90 °. When the contact angle exceeds the upper limit value, the display pattern printed on the sheet material 21 is easily peeled off.

  Further, the sheet material 21 may be subjected to a stretching process or may not be subjected to a stretching process, but is preferably not subjected to a stretching process.

  As shown in FIG. 2, the sheet material 21 is conveyed from the left side to the right side in FIG. 2 by a conveyance device (not shown), while corona discharge treatment by the corona discharge device 100 described later, printing by the printing device 200, and ultraviolet rays. The ink is cured by irradiation. In the present embodiment, only the sheet material 21 moves, and the corona discharge device 100, the printing device 200, and the ultraviolet irradiation device (not shown) are configured not to move.

  The moving speed of the sheet material 21 is not particularly limited, and is appropriately set according to various conditions, but is preferably about 350 to 450 mm / second, and more preferably about 380 to 420 mm / second.

[2]
A discharge treatment is performed on the surface of the portion of the sheet material 21 to be printed. Thereby, the wettability of the surface of the site | part which prints the sheet material 21 improves, and peeling of the display pattern printed on the sheet material 21 can be prevented.

  The discharge treatment is not particularly limited as long as it uses discharge, and examples thereof include corona discharge treatment and plasma treatment. Among these, corona discharge treatment is preferable. This embodiment demonstrates the case where a corona discharge process is performed. Hereinafter, the corona discharge treatment is also simply referred to as “discharge treatment”.

  The corona discharge device 100 has a pair of electrodes (not shown), and generates a corona discharge by applying a high frequency voltage between the electrodes. The sheet material 21 moves between a pair of electrodes of the corona discharge device 100. At this time, the surface of the portion to be printed on the sheet material 21 is exposed to corona discharge, and subjected to corona discharge treatment.

  Here, the electrode of the corona discharge device 100 and the sheet material 21 are separated by a predetermined distance. The distance between the surface of the sheet material 21 on which the corona discharge treatment is performed and the electrode on the surface side on which the corona discharge treatment is performed is not particularly limited and is appropriately set according to various conditions. It is preferably about 10 mm, more preferably about 3 to 6 mm. Thereby, peeling of the display pattern printed on the sheet material 21 can be prevented more reliably.

  In the discharge treatment, the frequency of the voltage applied between the electrodes of the corona discharge device 100 is not particularly limited, and is appropriately set according to various conditions, but is preferably about 20 to 50 kHz, and preferably 30 to 40 kHz. More preferably, it is about. Thereby, peeling of the display pattern printed on the sheet material 21 can be prevented more reliably.

  Moreover, it is preferable that a discharge process is performed by performing the discharge process with respect to the sheet material 21 currently conveyed. The conveying speed of the sheet material 21 is not particularly limited, and is appropriately set according to various conditions, but is preferably about 350 to 450 mm / second, and more preferably about 380 to 420 mm / second. Thereby, peeling of the display pattern printed on the sheet material 21 can be prevented more reliably.

  The discharge treatment may be performed under reduced pressure, under pressure, or atmospheric pressure, but is preferably performed under atmospheric pressure.

  Further, the atmosphere gas in the discharge treatment, that is, the treatment gas is not particularly limited, and examples thereof include helium, argon, nitrogen, carbon monoxide, carbon dioxide, oxygen, air, and the like, one or two of these. A combination of more than one species can be used. Of these, air or oxygen is preferable, and air is particularly preferable.

[3]
A predetermined display pattern is printed on the portion of the sheet material 21 subjected to the discharge treatment using ultraviolet curable ink.

  The printing method is not particularly limited, and examples thereof include letterpress printing, intaglio printing, and offset printing. Among these, letterpress printing or offset printing is preferable.

The printing apparatus 200 includes a pair of rollers 210 that are rotatably installed. The sheet material 21 moves between the rollers 210 of the printing apparatus 200 while being in close contact with the rollers 210. At that time, ink is transferred from the roller 210 to the sheet material 21, and a predetermined display pattern is printed.
The ink to be used is not particularly limited as long as it is an ultraviolet curable ink.

  In the manufacturing method of the present embodiment, even when such a hydrophobic ink is used, the discharge treatment is performed under the above-described conditions and the ink is cured under the conditions described later, so that the display pattern can be reliably peeled off from the sheet material 21. Can be prevented.

  The printing may be single color printing or multicolor printing. In the case of multicolor printing, the printing may be performed simultaneously, or may be performed for each color.

[4]
The ink after printing on the surface of the sheet material 21 is irradiated with ultraviolet rays by an unillustrated ultraviolet irradiation device to cure the ink.

  Moreover, the irradiation energy of ultraviolet rays is not particularly limited, and is appropriately set according to various conditions, but is preferably about 4.8 to 6.0 kW, and preferably about 5.0 to 5.8 kW. More preferred. Thereby, peeling of the display pattern printed on the sheet material 21 can be prevented more reliably.

  Moreover, it is preferable that irradiation of an ultraviolet-ray is performed by radiating an ultraviolet-ray with respect to the conveyed sheet material 21. FIG. The conveying speed of the sheet material 21 is not particularly limited, and is appropriately set according to various conditions, but is preferably about 350 to 450 mm / second, and more preferably about 380 to 420 mm / second. Thereby, peeling of the display pattern printed on the sheet material 21 can be prevented more reliably.

  In addition, the light applied to the ink after printing is ultraviolet light in this embodiment, but is not limited thereto, and may include light having a wavelength band different from ultraviolet light in addition to ultraviolet light. That is, any light containing ultraviolet rays may be used.

  In addition, you may perform a predetermined | prescribed base treatment to the surface of the site | part which prints the sheet material 21 before the said printing. This ground treatment may be performed before or after the discharge treatment, but is preferably performed after the discharge treatment.

  Further, after the ink is cured, a predetermined coat layer may be formed so as to cover the surface of the portion where the sheet material 21 is printed.

[5]
The sheet material 21 is cut for each bag body, the discharge port 6 is fused to the cut back body 2, the liquid 30 is filled in the first space 3, and the liquid 40 is filled in the second space 4. Fill. The liquid 40 is filled into the second space 4 through the discharge port 6. The filling of the liquid 30 into the first space 3 is performed by directly inserting a nozzle for filling the liquid into the first space 3, and after filling the liquid 30, the hole into which the nozzle is inserted is sealed. And block it.

[6]
The medical bag 1 in which the liquids 30 and 40 are sealed is wrapped in a packaging material (not shown) in a state where it is folded in two at the partition part 5, and the medical bag 1 is stored in the packaging material. Get the package. By packaging the medical bag 1 in a state in which the medical bag 1 is bent at the partition portion 5, when the medical bag 1 is pressurized, such as when the bag package is transported, the partition portion 5 is peeled off. Can be prevented. Moreover, compared with the case where the medical bag 1 is bent after high-pressure steam sterilization described later, there is an advantage that it does not take time and effort.

[7]
High-pressure steam sterilization is performed on the bag individual package.
At this time, the medical bag 1 is placed under high pressure and high temperature. However, since the discharge treatment and the ink are cured under the above-described conditions, the display pattern printed on the sheet material 21 can be prevented from being peeled off. it can.

  As described above, according to the method for manufacturing the medical bag 1, since the corona discharge treatment is performed on the surface of the portion to which the sheet material 21 is printed, the wettability of the surface of the portion to which the sheet material 21 is printed. As a result, peeling of the display pattern printed on the sheet material 21 can be prevented.

  As mentioned above, although the manufacturing method and medical bag of the medical bag of this invention were demonstrated based on embodiment of illustration, this invention is not limited to this, The structure of each part has the same function. Any configuration can be substituted. Moreover, other arbitrary structures and processes may be added to the present invention.

Next, specific examples of the present invention will be described.
Example 1
As a sheet material, polypropylene and a hydrogenated styrene-butadiene copolymer are blended at a weight ratio of 6: 4, and a resin obtained by mixing is molded into a cylindrical shape (folded diameter 220 mm) with a thickness of 300 μm by inflation molding, What sealed the predetermined location and formed the partition part was prepared.

  Then, using this sheet material, the corona discharge treatment in step [2], the display pattern in step [3] is printed, the ink is cured by ultraviolet irradiation in step [4], and the sheet material in step [5] is cut. , The fusion of the discharge port, the filling of the liquid into the first space and the second space, the packaging in the step [6], the high-pressure steam sterilization in the step [7], and the medical bag shown in FIG. The individual bag body packaged in the material was manufactured. The size of the medical bag was 25 cm × 12.5 cm in the bag body. Each condition, method, physical property, etc. are as follows.

Young's modulus at room temperature (20-30 ° C.) of sheet material: average 198 MPa
Contact angle of water at room temperature (20-30 ° C.) of sheet material: 80-90 °
Corona discharge treatment, printing, conveying speed of sheet material during ultraviolet irradiation: 400 mm / sec. The surface on which the corona discharge treatment is performed on the sheet material during corona discharge treatment, and the electrode on the surface side on which the corona discharge treatment is performed. Distance between: 4mm
Frequency of voltage applied between electrodes in corona discharge treatment: 35 ± 5 kHz
Printing method: Topographic printing Ink used for printing: UV curable ink Irradiation energy of ultraviolet rays for curing ink: 5.4 kW (maximum 6.0 kW)
UV irradiation time for curing ink: 400 seconds High-pressure steam sterilization: 115 ° C. × 15 minutes

(Comparative Example 1)
Except not performing a corona discharge process, it carried out similarly to the said Example 1, and manufactured the bag individual package which accommodates a medical bag in a packaging material.

[Evaluation]
When the state of the printed display pattern was observed after high-pressure steam sterilization, peeling of the display pattern was not confirmed in Example 1, but peeling of the display pattern was confirmed in Comparative Example 1.

DESCRIPTION OF SYMBOLS 1 Medical bag 2 Bag main body 21 Sheet material 22, 23 Seal part 24 Hole 3 1st space 4 2nd space 30, 40 Liquid 5 Partition part 6 Outlet 61 Outlet main body 62 Outer cylinder 100 Corona discharge device 200 Printing Equipment 210 Roller

Claims (10)

A method of manufacturing a medical bag using a sheet material,
A sheet material composed of a resin mainly composed of polypropylene, having a Young's modulus of 100 to 250 MPa, and a water contact angle of 70 to 90 ° is prepared.
Perform discharge treatment on the surface of the part to be printed on the sheet material,
Printing using ultraviolet curable ink on the discharge treated portion of the sheet material,
A method for producing a medical bag, wherein the ink after printing is irradiated with ultraviolet rays to cure the ink.   The method for producing a medical bag according to claim 1, wherein the content of the polypropylene in the constituent material of the sheet material is more than 50 wt%.   The method for manufacturing a medical bag according to claim 1, wherein the discharge treatment is a corona discharge treatment.   The method for manufacturing a medical bag according to any one of claims 1 to 3, wherein in the discharge treatment, a frequency of a voltage applied between electrodes for generating discharge is 20 to 50 kHz.   The method for manufacturing a medical bag according to any one of claims 1 to 4, wherein, in the discharge treatment, a distance between an electrode that causes discharge and the sheet material is 2 to 10 mm.   The method for producing a medical bag according to any one of claims 1 to 5, wherein the discharge treatment is performed while relatively moving the sheet material and an electrode that generates discharge at a speed of 350 to 450 mm / sec. .   The method of manufacturing a medical bag according to any one of claims 1 to 6, wherein the irradiation energy of the ultraviolet rays is 4.8 to 6.0 kW.   The method for manufacturing a medical bag according to any one of claims 1 to 7, wherein the ultraviolet ray is irradiated while moving the sheet material at a speed of 350 to 450 mm / sec.   The method for producing a medical bag according to claim 1, wherein the printing is letterpress printing.   A medical bag manufactured by the method for manufacturing a medical bag according to claim 1.

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