JP2011219383A - External preparation for skin - Google Patents
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- JP2011219383A JP2011219383A JP2010087553A JP2010087553A JP2011219383A JP 2011219383 A JP2011219383 A JP 2011219383A JP 2010087553 A JP2010087553 A JP 2010087553A JP 2010087553 A JP2010087553 A JP 2010087553A JP 2011219383 A JP2011219383 A JP 2011219383A
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- skin
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- external preparation
- feeling
- polymer
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- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 33
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 28
- 239000000843 powder Substances 0.000 claims abstract description 10
- 229930195712 glutamate Natural products 0.000 claims abstract description 9
- 239000004215 Carbon black (E152) Substances 0.000 claims abstract description 8
- 229930195733 hydrocarbon Natural products 0.000 claims abstract description 8
- 150000002430 hydrocarbons Chemical class 0.000 claims abstract description 8
- 229920002379 silicone rubber Polymers 0.000 claims abstract description 8
- -1 acyl glutamate Chemical compound 0.000 claims abstract description 7
- 235000011187 glycerol Nutrition 0.000 claims description 15
- 229920002554 vinyl polymer Polymers 0.000 claims description 8
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 9
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 229940008099 dimethicone Drugs 0.000 description 14
- 239000004205 dimethyl polysiloxane Substances 0.000 description 14
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 14
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 14
- 230000003020 moisturizing effect Effects 0.000 description 11
- 229920006037 cross link polymer Polymers 0.000 description 10
- 239000003921 oil Substances 0.000 description 10
- 239000006210 lotion Substances 0.000 description 9
- 235000019198 oils Nutrition 0.000 description 9
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 8
- 239000002537 cosmetic Substances 0.000 description 7
- 235000014113 dietary fatty acids Nutrition 0.000 description 7
- 239000000194 fatty acid Substances 0.000 description 7
- 229930195729 fatty acid Natural products 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 6
- 239000000839 emulsion Substances 0.000 description 6
- 150000004665 fatty acids Chemical class 0.000 description 6
- 229920000642 polymer Polymers 0.000 description 6
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 6
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 5
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 5
- 125000002252 acyl group Chemical group 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 235000019864 coconut oil Nutrition 0.000 description 4
- 239000003240 coconut oil Substances 0.000 description 4
- 238000013329 compounding Methods 0.000 description 4
- 239000006071 cream Substances 0.000 description 4
- 238000004945 emulsification Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 4
- 239000012071 phase Substances 0.000 description 4
- 229940032094 squalane Drugs 0.000 description 4
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000003995 emulsifying agent Substances 0.000 description 3
- 229940045898 sodium stearoyl glutamate Drugs 0.000 description 3
- KDHFCTLPQJQDQI-BDQAORGHSA-M sodium;(4s)-4-amino-5-octadecanoyloxy-5-oxopentanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC(=O)OC(=O)[C@@H](N)CCC([O-])=O KDHFCTLPQJQDQI-BDQAORGHSA-M 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical group CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- JVTIXNMXDLQEJE-UHFFFAOYSA-N 2-decanoyloxypropyl decanoate 2-octanoyloxypropyl octanoate Chemical compound C(CCCCCCC)(=O)OCC(C)OC(CCCCCCC)=O.C(=O)(CCCCCCCCC)OCC(C)OC(=O)CCCCCCCCC JVTIXNMXDLQEJE-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 125000005250 alkyl acrylate group Chemical group 0.000 description 2
- 235000015278 beef Nutrition 0.000 description 2
- 235000010290 biphenyl Nutrition 0.000 description 2
- 239000004305 biphenyl Substances 0.000 description 2
- WODOUQLMOIMKAL-FJSYBICCSA-L disodium;(2s)-2-(octadecanoylamino)pentanedioate Chemical compound [Na+].[Na+].CCCCCCCCCCCCCCCCCC(=O)N[C@H](C([O-])=O)CCC([O-])=O WODOUQLMOIMKAL-FJSYBICCSA-L 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229940057995 liquid paraffin Drugs 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229940077092 sodium myristoyl glutamate Drugs 0.000 description 2
- FCBUGCHAVCFTHW-NTISSMGPSA-N sodium;(2s)-2-(tetradecanoylamino)pentanedioic acid Chemical compound [Na].CCCCCCCCCCCCCC(=O)N[C@H](C(O)=O)CCC(O)=O FCBUGCHAVCFTHW-NTISSMGPSA-N 0.000 description 2
- 239000003760 tallow Substances 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- KZRXPHCVIMWWDS-AWEZNQCLSA-N (4S)-4-amino-5-dodecanoyloxy-5-oxopentanoic acid Chemical compound CCCCCCCCCCCC(=O)OC(=O)[C@@H](N)CCC(O)=O KZRXPHCVIMWWDS-AWEZNQCLSA-N 0.000 description 1
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 1
- OSCJHTSDLYVCQC-UHFFFAOYSA-N 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)NC(C)(C)C)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 OSCJHTSDLYVCQC-UHFFFAOYSA-N 0.000 description 1
- LEEDMQGKBNGPDN-UHFFFAOYSA-N 2-methylnonadecane Chemical compound CCCCCCCCCCCCCCCCCC(C)C LEEDMQGKBNGPDN-UHFFFAOYSA-N 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 1
- 229930064664 L-arginine Natural products 0.000 description 1
- 235000014852 L-arginine Nutrition 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000003429 antifungal agent Substances 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 235000009697 arginine Nutrition 0.000 description 1
- 125000006267 biphenyl group Chemical group 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- 229940075510 carbopol 981 Drugs 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 229940079784 disodium stearoyl glutamate Drugs 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 239000010696 ester oil Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 229940075507 glyceryl monostearate Drugs 0.000 description 1
- XJNUECKWDBNFJV-UHFFFAOYSA-N hexadecyl 2-ethylhexanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)C(CC)CCCC XJNUECKWDBNFJV-UHFFFAOYSA-N 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 229940071085 lauroyl glutamate Drugs 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 229920001083 polybutene Polymers 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- RWDOCBHBDDFEQV-UQKRIMTDSA-M potassium;(4s)-4-amino-5-dodecanoyloxy-5-oxopentanoate Chemical compound [K+].CCCCCCCCCCCC(=O)OC(=O)[C@@H](N)CCC([O-])=O RWDOCBHBDDFEQV-UQKRIMTDSA-M 0.000 description 1
- XIBUKSQTWSKJMQ-QTNFYWBSSA-M potassium;(4s)-4-amino-5-hydroxy-5-oxopentanoate;hydrate Chemical compound O.[K+].[O-]C(=O)[C@@H](N)CCC(O)=O XIBUKSQTWSKJMQ-QTNFYWBSSA-M 0.000 description 1
- KCQOKZAQSWTPIL-BDQAORGHSA-M potassium;(4s)-5-hydroxy-4-(octadecanoylamino)-5-oxopentanoate Chemical compound [H+].[K+].CCCCCCCCCCCCCCCCCC(=O)N[C@H](C([O-])=O)CCC([O-])=O KCQOKZAQSWTPIL-BDQAORGHSA-M 0.000 description 1
- KYLDDUZJZSKJER-NTISSMGPSA-M potassium;(4s)-5-hydroxy-5-oxo-4-(tetradecanoylamino)pentanoate Chemical compound [H+].[K+].CCCCCCCCCCCCCC(=O)N[C@H](C([O-])=O)CCC([O-])=O KYLDDUZJZSKJER-NTISSMGPSA-M 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920002050 silicone resin Polymers 0.000 description 1
- 229940083542 sodium Drugs 0.000 description 1
- 229940045944 sodium lauroyl glutamate Drugs 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- IWIUXJGIDSGWDN-UQKRIMTDSA-M sodium;(2s)-2-(dodecanoylamino)pentanedioate;hydron Chemical compound [Na+].CCCCCCCCCCCC(=O)N[C@H](C([O-])=O)CCC(O)=O IWIUXJGIDSGWDN-UQKRIMTDSA-M 0.000 description 1
- BVMJGZKBXAVKJN-UQKRIMTDSA-M sodium;(4s)-4-amino-5-dodecanoyloxy-5-oxopentanoate Chemical compound [Na+].CCCCCCCCCCCC(=O)OC(=O)[C@@H](N)CCC([O-])=O BVMJGZKBXAVKJN-UQKRIMTDSA-M 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000006097 ultraviolet radiation absorber Substances 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 239000004711 α-olefin Substances 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
Description
本発明は、みずみずしい使用感でありながら、しっとり感に優れしかもべたつかない使用感を発揮する皮膚外用剤に関する。 [Technical Field] The present invention relates to an external preparation for skin, which has a fresh feeling of use but exhibits a moist feeling and a non-sticky feeling of use.
通常スキンケアにおいては、水分や保湿成分を補給して皮膚にみずみずしさや潤いを与える化粧水と、水分や保湿成分と共に油分を補給して皮膚の保湿柔軟機能を高める乳液とを組み合わせて二段階で肌のお手入れが行われる。この二段階でのお手入れを一段階で済ませるための所謂オールインワンタイプの皮膚外用剤が上市されている。しかしながら、現在市場に出回っているオールインワンタイプの皮膚外用剤においては、みずみずしさを重視するあまりしっとり感に欠けるもの、しっとり感を重視するためにみずみずしさに欠けるものなど、みずみずしい使用感と、潤いを与える効果を兼ね備えた皮膚外用剤はいまだ存在しないのが現状である。 In normal skin care, skin is made up in two stages by combining a lotion that replenishes moisture and moisturizing ingredients to rejuvenate and moisturizes the skin, and an emulsion that replenishes oils together with moisture and moisturizing ingredients to enhance the skin's moisturizing and flexible function Caring for is done. A so-called all-in-one type skin external preparation is marketed to complete the two-stage care in one stage. However, all-in-one skin external preparations currently on the market have a fresh feeling of use and moisture, such as those lacking a moist feeling that emphasizes freshness and those lacking a freshness to emphasize moist feeling. Currently, there are no external skin preparations that have the effect of giving them.
またグリセリンは、高い保湿効果を有しており、化粧品等の皮膚外用剤において保湿剤として長年汎用されている。例えば、非特許文献1には、40%グリセリン含有保湿クリームを塗布することにより水分保持機能が上昇することが記載されている。さらに、グリセリンは、保湿効果に加えて優れた肌改善効果を有しており、たとえば特許文献1には、グリセリンを3〜25%含有する肌荒れ防止用油中水型乳化化粧料が記載されている。しかしながら、グリセリンは、ポリオール系化合物特有の特性により、配合量が多くなると独特のべたつき感が生じて使用感が悪くなる。さらに、より保湿効果や肌改善効果を高めるために、化粧水、乳液ともにグリセリンを多量に配合したものを用いた場合、スキンケア後の肌がべたつき、またその後メーキャップを行う場合にファンデーションが厚付きしまた不均一になるなど、化粧のりが悪くなるという問題があった。一方、化粧水と乳液に配合するトータルのグリセリン量を減らすと、べたつき感やファンデーションの厚付き等は改善されるが、保湿効果が十分ではなく、特に乾燥肌の場合肌荒れを生じるなど、十分なスキンケア効果をもたらすことはできない。そこで、9〜12質量%のグリセリンを含有する第1の水性化粧料と、1〜4質量%のグリセリンを含有する第2の水性化粧料とを含む、スキンケア化粧料キットが提案されている(特許文献2参照)。 Glycerin has a high moisturizing effect and has been widely used for many years as a moisturizing agent in skin external preparations such as cosmetics. For example, Non-Patent Document 1 describes that the moisture retention function is increased by applying a 40% glycerin-containing moisturizing cream. Furthermore, glycerin has an excellent skin improvement effect in addition to a moisturizing effect. For example, Patent Document 1 describes a water-in-oil emulsified cosmetic for preventing rough skin containing 3 to 25% of glycerin. Yes. However, glycerin has a unique sticky feeling due to a characteristic characteristic of a polyol-based compound, and a feeling of use becomes worse when the amount is increased. In addition, in order to further enhance the moisturizing effect and skin improvement effect, if lotion and milky lotion containing a large amount of glycerin is used, the skin becomes sticky after skin care, and the foundation will thicken after makeup. There was a problem that makeup became worse, such as unevenness. On the other hand, reducing the total amount of glycerin added to the lotion and emulsion improves the feeling of stickiness and the thickness of the foundation, but the moisturizing effect is not sufficient, especially when dry skin causes rough skin. Can not bring skin care effect. Therefore, a skin care cosmetic kit including a first aqueous cosmetic containing 9 to 12% by mass of glycerin and a second aqueous cosmetic containing 1 to 4% by mass of glycerin has been proposed ( Patent Document 2).
本発明においては、みずみずしい使用感と、潤いを与える効果を兼ね備えた皮膚外用剤を提供することを目的とした。 The object of the present invention is to provide an external preparation for skin having both a fresh feeling of use and a moisturizing effect.
本発明は、成分(A)〜成分(E)、すなわち成分(A)シリコーンエラストマー粉末と、成分(B)グリセリンと、成分(C)アシルグルタミン酸塩と、成分(D)炭化水素油と、成分(E)カルボキシビニルポリマー及び/又はアルキル変性カルボキシビニルポリマーを含有する皮膚外用剤に関する。 The present invention includes components (A) to (E), that is, component (A) silicone elastomer powder, component (B) glycerin, component (C) acyl glutamate, component (D) hydrocarbon oil, and component (E) It is related with the skin external preparation containing a carboxy vinyl polymer and / or an alkyl modified carboxy vinyl polymer.
本発明の皮膚外用剤は、みずみずしい使用感でありながら、潤いを与える効果に優れしかもべたつかない使用感を発揮する。また本発明の皮膚外用剤は、1品で化粧水、乳液、クリームの3品の機能を兼ね備えるものである。 The external preparation for skin of the present invention exhibits a feeling of use that is excellent in moisturizing effect and is not sticky while having a fresh feeling of use. Moreover, the external preparation for skin of the present invention is a single product that has the functions of three products of lotion, milky lotion, and cream.
本発明の皮膚外用剤は、成分(A)〜成分(E)、すなわち成分(A)シリコーンエラストマー粉末と、成分(B)グリセリンと、成分(C)アシルグルタミン酸塩と、成分(D)炭化水素油と、成分(E)カルボキシビニルポリマー及び/又はアルキル変性カルボキシビニルポリマーを含有する。これらの成分に関し、個々に説明する。 The external preparation for skin of the present invention comprises components (A) to (E), that is, component (A) silicone elastomer powder, component (B) glycerin, component (C) acyl glutamate, and component (D) hydrocarbon. Oil and component (E) carboxyvinyl polymer and / or alkyl-modified carboxyvinyl polymer. These components will be described individually.
本発明で用いる成分(A)シリコーンエラストマー粉末としては、たとえば(ジメチコン/ビニルジメチコン/メチコン)クロスポリマー、ジメチコン/ビニルジメチコン)クロスポリマー、(ジフェニルジメチコン/ビニルジフェニルジメチコン/シルセスキオキサン)クロスポリマーなどに代表される弾性シリコーン樹脂球状粉体から選ばれる粉末の一種または二種以上が挙げられる。 Examples of the component (A) silicone elastomer powder used in the present invention include (dimethicone / vinyl dimethicone / methicone) cross polymer, dimethicone / vinyl dimethicone) cross polymer, (diphenyl dimethicone / vinyl diphenyl dimethicone / silsesquioxane) cross polymer, and the like. One or two or more kinds of powders selected from elastic silicone resin spherical powders represented by
このうち、(ジメチコン/ビニルジメチコン/メチコン)クロスポリマーとしては、例えば、信越化学工業社製のKSP−100が挙げられる。(ジメチコン/ビニルジメチコン)クロスポリマーとしては、例えば、東レ・ダウコーニング社製のトレフィルE−506Sが挙げられる。(ジフェニルジメチコン/ビニルジフェニルジメチコン/シルセスキオキサン)クロスポリマーとしては、信越化学工業社製のKSP−300が挙げられる。 Among these, examples of the (dimethicone / vinyl dimethicone / methicone) crosspolymer include KSP-100 manufactured by Shin-Etsu Chemical Co., Ltd. Examples of the (dimethicone / vinyl dimethicone) crosspolymer include Trefil E-506S manufactured by Toray Dow Corning. Examples of the (diphenyldimethicone / vinyldiphenyldimethicone / silsesquioxane) crosspolymer include KSP-300 manufactured by Shin-Etsu Chemical Co., Ltd.
本発明において成分(A)シリコーンエラストマー粉末の配合量は0.1〜2質量%である。成分(A)シリコーンエラストマー粉末の配合量が皮膚外用剤に対して0.1質量%未満であると、使用性(のび)効果が十分に発揮されなくなる場合がある。 In this invention, the compounding quantity of component (A) silicone elastomer powder is 0.1-2 mass%. When the blending amount of the component (A) silicone elastomer powder is less than 0.1% by mass with respect to the external preparation for skin, the usability (spreading) effect may not be sufficiently exhibited.
本発明で用いる成分(B)グリセリンの皮膚外用剤へのの配合量は、10〜40質量%である。10質量%未満の配合ではしっとり感が得られなくなる場合がある。40質量%を超えて配合するとべたつきが生じる場合がある。 The compounding quantity to the skin external preparation of the component (B) glycerin used by this invention is 10-40 mass%. If it is less than 10% by mass, moist feeling may not be obtained. If it exceeds 40% by mass, stickiness may occur.
本発明で用いる成分(C)アシルグルタミン酸塩の具体例としては、ヤシ油脂肪酸アシルグルタミン酸カリウム、ヤシ油脂肪酸アシルグルタミン酸ナトリウム、ヤシ油脂肪酸アシルグルタミン酸トリエタノールアミン、ラウロイルグルタミン酸カリウム、ラウロイルグルタミン酸ナトリウム、ラウロイルグルタミン酸トリエタノールアミン、ミリストイルグルタミン酸カリウム、ミリストイルグルタミン酸ナトリウム、ステアロイルグルタミン酸カリウム、ステアロイルグルタミン酸ナトリウム、ステアロイルグルタミン酸ニナトリウム、硬化牛脂脂肪酸アシルグルタミン酸ナトリウム、ヤシ油脂肪酸・硬化牛脂脂肪酸アシルグルタミン酸ナトリウムなどを例示することができる。これら成分は、1種を単独で用いてもよく、2種以上を適宜組合せて用いることもできる。好適な成分(C)としては、高温保存時の乳化安定性を向上させる観点から、ラウロイルグルタミン酸ナトリウム、ミリストイルグルタミン酸ナトリウム、ステアロイルグルタミン酸ナトリウムが好ましく、ステアロイルグルタミン酸ナトリウムを用いるのがより好ましい。 Specific examples of the component (C) acyl glutamate used in the present invention include coconut oil fatty acid acyl glutamate potassium, coconut oil fatty acid acyl glutamate sodium, coconut oil fatty acid acyl glutamate triethanolamine, lauroyl glutamate potassium, lauroyl glutamate sodium, lauroyl glutamate Examples include triethanolamine, potassium myristoyl glutamate, sodium myristoyl glutamate, potassium stearoyl glutamate, sodium stearoyl glutamate, disodium stearoyl glutamate, sodium hard beef tallow fatty acid acyl glutamate, coconut oil fatty acid, hard beef tallow fatty acid acyl glutamate, and the like. These components may be used alone or in combination of two or more. As a preferred component (C), sodium lauroyl glutamate, sodium myristoyl glutamate, and sodium stearoyl glutamate are preferred, and sodium stearoyl glutamate is more preferred from the viewpoint of improving the emulsion stability during high temperature storage.
本発明において成分(C)アシルグルタミン酸塩の配合量は0.1〜5.0質量%、好ましくは0.1〜1質量%である。0.1質量%未満の配合では乳化安定性が保てない場合がある。5.0質量%を超えて配合しても、これ以上の乳化効果の向上は認められない場合がある。 In this invention, the compounding quantity of component (C) acyl glutamate is 0.1-5.0 mass%, Preferably it is 0.1-1 mass%. If the blending amount is less than 0.1% by mass, the emulsion stability may not be maintained. Even if it exceeds 5.0 mass%, further improvement in the emulsification effect may not be observed.
本発明で用いる成分(D)炭化水素油としては、25℃で液状で、合成又は天然由来のものが含まれる。かかる炭化水素油としては、液状ラノリン、流動パラフィン、流動イソパラフィン、α−オレフィンオリゴマー、ポリブテン、水添ポリオレフィン、スクワラン等が挙げられる。これらのうち、流動パラフィン、スクワラン等がしっとり感向上の点から好ましい。 The component (D) hydrocarbon oil used in the present invention includes those which are liquid at 25 ° C. and are synthetically or naturally derived. Such hydrocarbon oils include liquid lanolin, liquid paraffin, liquid isoparaffin, α-olefin oligomer, polybutene, hydrogenated polyolefin, squalane and the like. Among these, liquid paraffin, squalane and the like are preferable from the viewpoint of improving moist feeling.
成分(D)の炭化水素油は、1種以上を用いることができ、1〜10質量%配合することが好ましい。1質量%未満の配合ではしっとり感向上効果が認められない場合がある。10質量%を超えて配合すると、べたつきの原因となり得る。 1 or more types can be used for the hydrocarbon oil of a component (D), and it is preferable to mix | blend 1-10 mass%. When the amount is less than 1% by mass, the moist feeling improvement effect may not be recognized. If it exceeds 10% by mass, it may cause stickiness.
成分(E)カルボキシビニルポリマー及び/又はアルキル変性カルボキシビニルポリマーについて説明する。 The component (E) carboxyvinyl polymer and / or the alkyl-modified carboxyvinyl polymer will be described.
カルボキシビニルポリマーは、主としてアクリル酸の重合体であり、具体例としては、特に制限はなく、目的に応じて適宜選択することができ、例えば、カーボポール981(ルーブリゾール社製)、カーボポール980(ルーブリゾール社製)、カーボポール941(ルーブリゾール社製)、カーボポール940(ルーブリゾール社製)、カーボポールUltrez10(ルーブリゾール社製)、カーボポール2984(ルーブリゾール社製)、カーボポールETD2050(ルーブリゾール社製)等が挙げられ、これらを好適に用いることができる。 The carboxyvinyl polymer is mainly a polymer of acrylic acid, and specific examples thereof are not particularly limited and can be appropriately selected according to the purpose. For example, Carbopol 981 (manufactured by Lubrizol), Carbopol 980 (Manufactured by Lubrizol), Carbopol 941 (manufactured by Lubrizol), Carbopol 940 (manufactured by Lubrizol), Carbopol Ultrez 10 (manufactured by Lubrizol), Carbopol 2984 (manufactured by Lubrizol), Carbopol ETD2050 (Made by Lubrizol Co., Ltd.) and the like, and these can be used preferably.
アルキル変性カルボキシビニルポリマーは、アクリル酸、メタクリル酸又はこれらの単純エステルからなるモノマー1種以上と、アクリル酸アルキルの共重合体である。INCI名:Acrylates/C10-30 Alkyl Acrylate Crosspolymer[(アクリル酸/アクリル酸(C 10-30)アルキル)クロスポリマー]等として知られるもので、市販のものを用いることができる。市販品としては、具体的には、「Carbopol ETD 2020 Polymer」、「Carbopol 1342 Polymer」、「Carbopol 1382 Polymer」、「Carbopol Ultrez 20 Polymer」、「Carbopol Ultrez 21 Polymer」、「Pemulen TR-1」、「Pemulen TR-2」(以上、いずれもNoveon社製)等が挙げられ、これらを好適に用いることができる。 The alkyl-modified carboxyvinyl polymer is a copolymer of one or more monomers composed of acrylic acid, methacrylic acid or simple esters thereof and an alkyl acrylate. INCI name: Acrylates / C10-30 Alkyl Acrylate Crosspolymer [(acrylic acid / acrylic acid (C10-30) alkyl) crosspolymer], etc., and commercially available products can be used. As commercially available products, specifically, `` Carbopol ETD 2020 Polymer '', `` Carbopol 1342 Polymer '', `` Carbopol 1382 Polymer '', `` Carbopol Ultrez 20 Polymer '', `` Carbopol Ultrez 21 Polymer '', `` Pemulen TR-1 '', “Pemulen TR-2” (all of which are manufactured by Noveon) and the like can be used.
カルボキシビニルポリマー及び/又はアルキル変性カルボキシビニルポリマーは、1種又は2種以上を用いることができる。カルボキシビニルポリマー及び/又はアルキル変性カルボキシビニルポリマーは、通常、塩基性物質で中和して用いられる。用いられる塩基性物質としては、例えば、トリエタノールアミン、モノエタノールアミンなどのアルカノールアミン類、アンモニア、水酸化ナトリウム、水酸化カリウムなどの無機塩基、アルギニンなどの塩基性アミノ酸などが例示される。また、塩基性物質の添加量は、カルボキシビニルポリマー及び/又はアルキル変性カルボキシビニルポリマーを中和するのに充分な量であり、これら成分の種類や使用量に応じて適宜配合すればよい。 1 type (s) or 2 or more types can be used for a carboxy vinyl polymer and / or an alkyl modified carboxy vinyl polymer. The carboxyvinyl polymer and / or the alkyl-modified carboxyvinyl polymer is usually used after neutralization with a basic substance. Examples of the basic substance to be used include alkanolamines such as triethanolamine and monoethanolamine, inorganic bases such as ammonia, sodium hydroxide and potassium hydroxide, and basic amino acids such as arginine. Moreover, the addition amount of the basic substance is an amount sufficient to neutralize the carboxyvinyl polymer and / or the alkyl-modified carboxyvinyl polymer, and may be appropriately blended depending on the type and amount of use of these components.
成分(E)の配合量は、0.1〜1質量%である。0.1質量%未満の配合では充分な増粘効果を得ることができない。 The compounding quantity of a component (E) is 0.1-1 mass%. If the amount is less than 0.1% by mass, a sufficient thickening effect cannot be obtained.
本発明の皮膚外用剤は、成分(D)を必須成分として含有する油相と、成分(B)と成分(E)と水を必須成分として含有する水相を、成分(C)を必須成分とする界面活性剤を用いて乳化することによって得られる水中油型乳化組成物である。 The skin external preparation of the present invention comprises an oil phase containing component (D) as an essential component, an aqueous phase containing components (B), component (E) and water as essential components, and component (C) as an essential component. It is an oil-in-water emulsion composition obtained by emulsifying using a surfactant.
本発明の皮膚外用剤には、上述の必須成分の他に、必要に応じて、通常、医薬品、医薬部外品、皮膚化粧料に配合される、水性成分、油性成分、保湿剤、色素、乳化剤、可溶化剤、紫外線吸収剤、増粘剤、薬剤、香料、樹脂、防菌防黴剤、アルコール類等を適宜配合することができる。 In addition to the above-mentioned essential components, the external preparation for skin of the present invention is usually mixed with pharmaceuticals, quasi-drugs, and skin cosmetics as necessary, aqueous components, oily components, humectants, pigments, An emulsifier, a solubilizer, an ultraviolet absorber, a thickener, a drug, a fragrance, a resin, a fungicide and an antifungal agent, alcohols, and the like can be appropriately blended.
さらに実施例により、本発明の特徴について詳細に説明する。 Further, the features of the present invention will be described in detail by way of examples.
表1に示す処方にて定法により皮膚外用剤を調製し、使用感の評価を行った。その結果、水溶性高分子で増粘剤であるカルボキシビニルポリマーを配合しない比較例1は、肌なじみが悪く、乳化安定性が良くなかった。乳化剤であるN−ステアロイル−L−グルタミン酸ナトリウムを同じく乳化剤であるショ糖脂肪酸エステルに代替した比較例2は、乳化安定性が悪く、上市に耐え得る品質ではなかった。グリセリンを、1,3−ブチレングリコールに代替した比較例3は、しっとり感に欠ける使用感であった。シリコーンエラストマー粉末である(ジメチコン/ビニルジメチコン/メチコン)クロスポリマーを精製水に代替した比較例4は、さっぱり感が感じられず、べたつきの残る使用感であった。炭化水素油であるスクワランをエステル油である2−エチルヘキサン酸セチルに代替した比較例5は、しっとり感に欠ける使用感であった。これら比較例に対し、本願発明の実施例1は、べたつきが無く、肌なじみが良好で、しっとり感、さっぱり感を兼ね備え、且つ乳化安定性が良好であるという優れた皮膚外用剤であった。さらに、実施例1を単品で使用するだけで、化粧水と乳液、クリームの全ての機能を兼ね備えた使用感であった。 A skin external preparation was prepared by a conventional method with the formulation shown in Table 1, and the feeling of use was evaluated. As a result, Comparative Example 1 in which a carboxyvinyl polymer that is a thickener and a water-soluble polymer was not blended had poor skin familiarity and poor emulsion stability. Comparative Example 2 in which sodium emulsifier N-stearoyl-L-glutamate was replaced with sucrose fatty acid ester, which is also an emulsifier, had poor emulsification stability and was not of a quality that could withstand commercial launch. Comparative Example 3 in which glycerin was replaced with 1,3-butylene glycol had a feeling of use lacking moist feeling. In Comparative Example 4 in which the silicone elastomer powder (dimethicone / vinyl dimethicone / methicone) crosspolymer was replaced with purified water, a refreshing feeling was not felt, and the feeling of stickiness remained. The comparative example 5 which replaced squalane which is hydrocarbon oil with cetyl 2-ethylhexanoate which is ester oil was the feeling of use lacking in a moist feeling. In contrast to these comparative examples, Example 1 of the present invention was an excellent skin external preparation having no stickiness, good skin familiarity, both moist and refreshing feeling, and good emulsification stability. Furthermore, it was the feeling of use which had all the functions of lotion, a milky lotion, and cream only by using Example 1 single-piece | unit.
[実施例2] 皮膚外用剤
(1)精製水 58.57(質量%)
(2)グリセリン 20.00
(3)カルボキシビニルポリマー 0.40
(4)ポリアクリル酸ナトリウム 0.03
(5)N−ステアロイル−L−グルタミン酸ナトリウム 0.50
(6)デカメチルシクロペンタシロキサン 5.00
(7)(ジメチコン/ビニルジメチコン/メチコン)クロスポリマー 0.50
(8)セチルアルコール 2.00
(9)自己乳化型モノステアリン酸グリセリン 1.00
(10)スクワラン 8.00
(11)L−アルギニン(10質量%水溶液) 4.00
製法
(1)〜(5)の水相成分と(6)〜(10)の油相成分をそれぞれ75℃に加熱、混合、均一化した後、水相に油相を添加して乳化後冷却する。45℃で(11)を添加して混合する。
[Example 2] External preparation for skin
(1) Purified water 58.57 (mass%)
(2) Glycerin 20.00
(3) Carboxyvinyl polymer 0.40
(4) Sodium polyacrylate 0.03
(5) Sodium N-stearoyl-L-glutamate 0.50
(6) Decamethylcyclopentasiloxane 5.00
(7) (Dimethicone / Vinyl Dimethicone / Methicone) Crosspolymer 0.50
(8) Cetyl alcohol 2.00
(9) Self-emulsifying glyceryl monostearate 1.00
(10) Squalane 8.00
(11) L-arginine (10% by mass aqueous solution) 4.00
Manufacturing method
The water phase components (1) to (5) and the oil phase components (6) to (10) are each heated, mixed and homogenized at 75 ° C., then added to the water phase and emulsified and cooled. . Add (11) at 45 ° C. and mix.
実施例2で得られた皮膚外用剤は、べたつきが無く、肌なじみが良好で、しっとり感、さっぱり感を兼ね備え、且つ乳化安定性が良好であるという優れた皮膚外用剤であった。さらに、実施例2を単品で使用するだけで、化粧水と乳液、クリームの全ての機能を兼ね備えた使用感であった。 The skin external preparation obtained in Example 2 was an excellent skin external preparation having no stickiness, good skin familiarity, both moist and refreshing feeling, and good emulsification stability. Furthermore, just by using Example 2 as a single item, it was a feeling of use that had all functions of lotion, emulsion and cream.
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